ISIS INNOVATION LTD. Patent applications |
Patent application number | Title | Published |
20140242103 | COMPOSITION - The present invention provides a modified influenza virus wherein the RNA of the haemagglutinin gene has been modified such that the haemagglutinin signal sequence is not expressed and the virus produces a haemagglutinin protein that lacks a functional signal sequence. The invention further provides composition comprising the modified virus and uses of the modified virus. | 08-28-2014 |
20140235994 | OPTIMIZED VELOCITY-SELECTIVE ARTERIAL SPIN LABELLING MODULE - A velocity selective preparation method is disclosed, for velocity selective arterial spin labelling (VSASL), the VSASL method using non-selective radiofrequency pulses and magnetic field gradients to modulate the longitudinal magnetization of the spins as a function of their velocity, wherein said velocity selective preparation method comprises an n-segment B | 08-21-2014 |
20140222354 | COMPUTATION METHOD OF RELATIVE CARDIOVASCULAR PRESSURE - The present invention provides a method for the determination of relative pressure fields from flow-sensitive data, the method comprising: applying a finite element discretisation to the Pressure Poisson Equation (PPE): | 08-07-2014 |
20140094449 | TREATMENT OF BIPOLAR DISORDER - The invention relates to sulphur- and/or selenium-containing compounds that can inhibit the enzyme inositol mono-phosphatase (IMPase), and which can be used in treating conditions that are treatable through inhibition of this enzyme, such as bi-polar disorder, the compounds having a structure of Formula (I), or is a pharmaceutically acceptable salt thereof; Formula (I); in which: E is S or Se and each of phenyl rings A and B is optionally substituted with one or more substituents, in which each substituent is selected independently from: (1) a halogen, which is preferably selected from F, Cl and Br; (2) C | 04-03-2014 |
20140083853 | ELECTROCHEMICAL SENSORS - An electrode for use in a electrochemical sensor comprises carbon modified with a chemically sensitive redox-active compound, excluding an electrode based on carbon having derivatised thereron two redox-active species wherein at least one of said species is selected from anthraquinone, phenanthrenequinone and N,N′-diphenyl-p-phenylenediamine (DPPD). The invention further provides a pH sensor comprising:
| 03-27-2014 |
20140050731 | Vaccine - The invention relates to a vaccine for the treatment of disease caused by | 02-20-2014 |
20140039450 | Method and Apparatus for Treating Respiratory Disease - A method of influencing bronchoconstriction in a mammal comprising applying a stimulation in one or more regions of the brain of the mammal, and an apparatus therefore. The method and apparatus may be used to treat a respiratory disease or sleep apnea. | 02-06-2014 |
20140034402 | ELECTRIC MACHINE - EVAPORATIVE COOLING - An electric machine comprises a rotor, preferably having permanent magnets, although other field generation means are available, and a stator. The stator has coils wound on stator bars for interaction with the magnetic field of the rotor across an air gap defined between them. The rotor comprises a housing of a chamber containing refrigerant. The rotor housing has heat dissipating fins accessible by the open environment whereby air movement relative to the housing caused at least by rotation of the rotor absorbs heat from the fins. The machine may be an axial flux machine, the coils being wound on bars that are disposed circumferentially spaced around a fixed axle of the machine forming a rotational axis of the rotor. The machine may be a wheel motor for a vehicle, wherein the wheel is mounted directly on the rotor housing. | 02-06-2014 |
20130257434 | ASSET DETECTION APPARATUS AND METHOD - Embodiments of the present invention provide a resonant assembly ( | 10-03-2013 |
20130253895 | Quantification of blood volume flow rates from dynamic angiography data - Systems and methods are disclosed for quantifying absolute blood volume flow rates by fitting a kinetic model incorporating blood volume, bolus dispersion and signal attenuation to dynamic angiographic data. A self-calibration method is described for both 2D and 3D data sets to convert the relative blood volume parameter into absolute units. The parameter values are then used to simulate the signal arising from a very short bolus, in the absence of signal attenuation, which can be readily encompassed within a vessel mask of interest. The volume flow rate can then be determined by calculating the blood volume within the vessel mask and dividing by the simulated bolus duration. This method is exemplified using non-contrast magnetic resonance imaging data from a flow phantom and the cerebral arteries of healthy volunteers and a patient with Moya-Moya disease acquired using a 2D vessel-encoded pseudo-continuous arterial spin labeling pulse sequence. This allows flow quantification in downstream vessels from each brain-feeding artery separately. The systems and methods can be of use in patients with a variety of cerebrovascular diseases, such as the assessment of collateral flow in patients with steno-occlusive disease or the evaluation of arteriovenous malformations. | 09-26-2013 |
20130249547 | Fast analysis method for non-invasive imaging of blood flow using vessel-encoded arterial spin labelling - Arterial spin labelling (ASL) MRI offers a non-invasive means to create blood-borne contrast in vivo for dynamic angiographic imaging. By spatial modulation of the ASL process it is possible to uniquely label individual arteries over a series of measurements, allowing each to be separately identified in the resulting images. This separation requires appropriate analysis for which a general framework has previously been proposed. Here the general framework is modified for fast analysis of non-invasive imaging of blood flow using vessel encoded arterial spin labelling (VE-ASL). This specifically addresses the issues of computational speed of the analysis and the robustness required to deal with real patient data. The modification applies various approaches for estimation of one or more parameters that change the way a vessel, for example an artery, is encoded to provide the fast analysis. | 09-26-2013 |
20130195641 | VANE ASSEMBLY FOR AN AXIAL FLOW TURBINE - A vane assembly ( | 08-01-2013 |
20130191033 | Analyzing spectra - Systems and methods for analyzing spectra are described. In analyzing the spectra, peaks are identified, and complexes and sub-complexes are assigned to their respective peaks. | 07-25-2013 |
20130102553 | Therapeutic Strategies For Prevention And Treatment Of Alzheimer's Disease - The invention relates to therapeutic agents for use in the prevention or treatment of Alzheimer's disease. In particular the invention relates to use of inhibitors of cell cycle reentry and progression to the G1/S transition or inhibitors of progression of the cell cycle through the G1/S transition point in the prevention or treatment of Alzheimer's disease. | 04-25-2013 |
20130064795 | IMMUNE MODULATION - The invention provides a layered double hydroxide compound for use in modulating an immune response to an antigen, and an immune modulator composition comprising the layered double hydroxide and an antigen. The compound is of formula (I), (II), or (III) | 03-14-2013 |
20130042910 | SOLAR CELL - The present invention provides a solar cell comprising an anode ( | 02-21-2013 |
20120309316 | COMMON COMMUNICATIONS DEVICE - A common communications device comprising an array of near-field coupled resonant elements, the elements each comprising a coupling portion comprising a loop portion with free ends, the device being provided in combination with a data transmission unit and a data reception unit, each unit having a coupling portion, the units being arranged to communicate with one another by means of the coupling portion of each unit and the common communications device, the coupling portion of the data transmission unit comprising a resonant element comprising a loop portion arranged to be near-field coupled to the loop portion of a first resonant element of the device, the coupling portion of the data reception unit comprising a resonant element comprising a loop portion arranged to be near-field coupled to the loop portion of a second resonant element of the device not being the first resonant element. | 12-06-2012 |
20120306588 | FLUX GUIDING STRUCTURE - Embodiments of the present invention provide a structure comprising: a flux guide comprising a plurality of resonant circuit elements ( | 12-06-2012 |
20120282184 | TREATMENT OF OBESITY - A method for the prevention or treatment of a condition selected from type 2 diabetes, obesity and metabolic syndrome comprising activating a GITRL pathway. Methods for screening for substances to treat these conditions, diagnosing or predicting these conditions and selecting and monitoring therapies. | 11-08-2012 |
20120265165 | Tissue Expander - This invention relates to a tissue expander for use in medical, veterinary and dental applications. The tissue expander comprises a self-inflating polymer network and a biodegradable polymer having a non-degraded state and a degraded state which in the non-degraded state constrains the inflation of the self-inflating polymer network and in the degraded state allows inflation of the self-inflating polymer network. In a preferred embodiment, the self-inflating polymer network and the biodegradable polymer form an interpenetrating polymer network or a semi-interpenetrating polymer network. Alternatively or in addition, the self-inflating polymer network forms a core and the biodegradable polymer forms coating which partially or fully surrounds the core. | 10-18-2012 |
20120078084 | SYSTEMS AND METHODS FOR SHORTENED LOOK LOCKER INVERSION RECOVERY (Sh-MOLLI) CARDIAC GATED MAPPING OF T1 - A shortened version of the MOLLI sequence (Sh-MOLLI) is described which generates rapid and high-resolution myocardial spin-lattice (T1) maps. The Sh-MOLLI technique is based on a significant abbreviation of pre-existing TI sampling scheme combined with the use of processing logic to bypass the major side effects of the above sampling scheme abbreviation and distinguish between long and short T1 relaxation times in order to conditionally utilize available TI samples for non-linear T1 fitting. | 03-29-2012 |
20110309726 | ELECTRIC MACHINE- MODULAR - An electric machine ( | 12-22-2011 |
20110309699 | ELECTRIC MACHINE-COOLING - An electric machine ( | 12-22-2011 |
20110309694 | ELECTRIC MACHINE- FLUX - An electric machine ( | 12-22-2011 |
20110237550 | 5-AZAINDOLE BISPHOSPHONATES - Novel 5-azaindole bisphosphonate compounds are disclosed, as well as methods of preparing the compounds, pharmaceutical compositions including the compounds, and administration of the compounds in methods of treating abnormal calcium and phosphate metabolism, including bone and joint diseases and other disorders. | 09-29-2011 |
20110230443 | IMIDAZO[1,2-a] PYRIDINYL BISPHOSPHONATES - Novel imidazo[1,2-α]pyridinyl bisphosphonate compounds are disclosed, as well as methods of preparing the compounds, pharmaceutical compositions including the compounds, and administration of the compounds in methods of treating abnormal calcium and phosphate metabolism, including bone and joint diseases and other disorders. | 09-22-2011 |
20100329652 | ELECTRICITY GENERATOR - A wind turbine and generator arrangement comprises a turbine that drives a self-excited induction generator via a shaft and mechanical gearbox. The induction generator includes an electrical circuit that includes a variable capacitance and a variable resistance. The variable capacitance may be constituted by a fixed capacitor and a triac under the control of a controller, or by a bank of capacitors switched by a relay under control of the controller. The variable resistance includes a triac controlled resistor or a bank of relay-switched resistors which constitute heating elements for heating domestic hot water. In use the generator frequency and voltage are allowed to ‘float’ whilst the optimal generator power output is maintained, but adjusting the impedance of the electrical circuit as the wind speed varies. | 12-30-2010 |
20100291061 | PROCESS FOR MAKING OLIGOPEPTIDES - There is described a method of synthesising a family of oligopeptides of predetermined amino acid sequence, which together make up from 7 amino acids to the complete amino acid sequence of a target protein, which comprises: synthesising a nucleic acid construct which codes for a fusion protein composed of overlapping peptides derived from the desired portion of the target protein, interspersed with regions which code for protease cleavage sites, expressing the nucleic acid construct in a suitable expression vector, harvesting the fusion protein corresponding to the nucleic acid sequence, and digesting the fusion protein with a protease selective for the cleavage sites to generate the oligopeptides. The oligopeptides may be generated in vitro or in vitro and may be used as vaccines against viral infections and in epitope mapping. | 11-18-2010 |
20100279317 | Method - The present invention provides a method for identifying a single or group of T cell receptors (TCR) protective and/or effective against a disease, having the following steps: i) obtaining T cells from a donor non-human animal; ii) adoptive transfer of the T cells into a plurality of T cell-deficient recipient non-human animals in a number such that at least one recipient animal is protected against the disease but at least one animal remains unprotected; and iii) determination of the TCR(s) present only in the protected animals. These TCR can be used to identify the determinants or antigens for inclusion in a vaccine or other treatment. | 11-04-2010 |
20100183676 | COMPOSITIONS COMPRISING OPA PROTEIN EPITOPES - The present invention relates to a composition comprising at least one purified Opa HV 1 protein epitope and at least one purified Opa HV2 protein epitope. The epitopes are preferably purified protein epitopes, preferably recombinant epitopes. The composition is preferably a pharmaceutical composition, more preferably a vaccine composition. The invention also relates to methods of immunisation and to specific formulations presented in the tables, and to novel nucleic acids encoding Opa alleles. | 07-22-2010 |
20100147705 | Amperometric Sensor and Method for the Detection of Gaseous Analytes Comprising A Working Electrode Comprising Edge Plane Pyrolytic Graphite - An electrochemical sensor and method of detecting gaseous analytes are provided, which involve the use of a working electrode comprising edge plane pyrolytic graphite. | 06-17-2010 |
20100134662 | IMAGE CAPTURE DEVICE AND METHOD - An image capture device ( | 06-03-2010 |
20100130382 | Liposome, Proteoliposome, Biochip, and Method for Producing Liposome and Proteoliposome - A liposome comprising a region of a lipid bilayer membrane with different membrane thicknesses, wherein each lipid bilayer membrane region is composed of a different lipid, and a thick membrane side in the region of the lipid bilayer membrane is formed of lipid having a phase transition temperature higher than that of the lipid forming a thin membrane side in the region of the lipid bilayer membrane. A proteoliposome, wherein the above-described liposome includes membrane proteins. A biochip, wherein the above-described liposome or the above-described proteoliposome is spread on a substrate. The above-described biochip, wherein the substrate includes at least one kind selected from the group consisting of mica, SiO | 05-27-2010 |
20100129433 | Proteoliposome, Production Method Thereof, and Biochip - A proteoliposome, which is obtained by removing a surfactant from a mixed solution including lipid, membrane proteins and the surfactant, wherein the content of the surfactant in the mixed solution is equal to or more than 1.5 times of the sum of a maximum amount of the surfactant associating with the lipid and a maximum amount of the surfactant associating with the membrane protein. A biochip wherein the above-described proteoliposome is spread on a substrate. A method for producing a proteoliposome by removing a surfactant from a mixed solution including lipid, membrane proteins and the surfactant, wherein the content of the surfactant in the mixed solution is made equal to or more than the sum of a maximum amount of the surfactant associating with the lipid and a maximum amount of the surfactant associating with the membrane protein. | 05-27-2010 |
20100113549 | PYRROLIDINE COMPOUNDS - The present invention relates to a process for the preparation of a pyrrolidone compound of the formula (I): where R | 05-06-2010 |
20100016560 | Vaccine - The invention relates to a vaccine for the treatment of disease caused by | 01-21-2010 |
20100015175 | Vaccine - The invention relates to a vaccine for the treatment of disease caused by | 01-21-2010 |
20100010211 | Vaccine - The invention relates to a vaccine for the treatment of disease caused by | 01-14-2010 |
20100010210 | Vaccine - The invention relates to a vaccine for the treatment of disease caused by | 01-14-2010 |
20090206838 | Systems and Methods for Correction of Inhomogeneities in Magnetic Resonance Images - Intensity inhomogeneities can obscure areas of interest and are problematic for MR image segmentation algorithms. An efficient approach to estimating these inhomogeneities by computing a calibration factor that is a function of an estimated bias field from a series of calibration scans is disclosed. This enables correction of T | 08-20-2009 |
20090006395 | SHAPE RECOGNITION METHODS AND SYSTEMS FOR SEARCHING MOLECULAR DATABASES - The present disclosure presents novel shape comparison methods. Methods for determining shape similarity between a query molecule and a target molecule and methods for screening one or more molecules in a database based on shape similarity to a query molecule are described. | 01-01-2009 |
20080311048 | Imaging Agent - The invention provides a conjugate comprising an iron containing colloidal particle, the particle being conjugated to one or more sugar targeting moieties. The conjugate is useful as a contrast agent in medical imaging, particularly in magnetic resonance imaging (MRI). The agents of the present invention may cross the blood brain barrier and so may be particularly useful in the monitoring or diagnosis of conditions affecting the brain. | 12-18-2008 |