HUNTINGTON MEDICAL RESEARCH INSTITUTES Patent applications |
Patent application number | Title | Published |
20150022204 | METHODS AND APPARATUS FOR PASADENA HYPERPOLARIZATION - The present subject matter relates to methods and apparatus for using hyperpolarization to improve imaging. Am exemplary embodiment, a PASADENA polarizer, is capable of delivering 2.5-5 ml of highly hyperpolarized biological | 01-22-2015 |
20140323839 | APPARATUS AND METHOD FOR TREATING OBSTRUCTIVE SLEEP APNEA - The present invention describes an apparatus, a systems and a method for the treatment of obstructive sleep apnea. the treatment involves monitoring the position of the tongue and/or the force exerted by the tongue an electrical stimulation of the hypoglossal nerve to move the tongue into an anterior position or to maintain the tongue in an anterior position. | 10-30-2014 |
20140308753 | METHODS OF DETERMINING LEVELS OF FREE AMINO ACIDS AND DIPEPTIDES AND DIAGNOSING ALZHEIMER'S DISEASE - Provided herein are methods of diagnosing Alzheimer's disease (“AD”) based on characteristic changes of the levels of certain free amino acids or dipeptides (collectively termed as “AD diagnosis markers”) in the body fluid sample of an individual, carnosine synthesis activities in the plasma, and dopamine synthesis activities in the plasma. Also provided are methods of simultaneously determining the levels of at least two free amino acids or dipeptides in the biological fluid sample of an individual. | 10-16-2014 |
20140065073 | IMAGING AGENTS AND METHODS OF USE THEREOF - Compositions and methods useful in connection with magnetic resonance imaging are provided. Metabolites hyperpolarized by dynanic nuclear polarization are used as reporter molecules in nuclear magnetic resonance (“NMR”) spectroscopy to study metabolic pathways and diagnose disease states. The reporter molecules include hyperpolarized glutamine and hyperpolarized acetate. The invention includes the reporter molecules, compositions including the reporter molecules in pharmaceutically acceptable carriers, methods for studying metabolic pathways that include introducing one or more of the reporter molecules to a mammalian subject and imaging a target substance using NMR spectroscopy, and kits useful in studying metabolic pathways that incorporate one or more of the reporter molecules and instructions for their use. | 03-06-2014 |
20130317349 | IMAGING AGENTS AND METHODS OF USE THEREOF - The present invention relates to compositions and methods useful in connection with magnetic resonance imaging. In various embodiments, the invention employs the PASADENA polarization technique to prepare contrast agents that target complementary molecules in the body and/or that are processed through predetermined, natural metabolic pathways. The invention includes methods of using the contrast agents and kits including the same. In one embodiment, a diagnostic and prognostic method relating to Alzheimer's disease is described. Further embodiments relate to medical devices including the contrast agents. | 11-28-2013 |
20130190836 | APPARATUS AND METHOD FOR TREATING OBSTRUCTIVE SLEEP APNEA - The present invention describes an apparatus, a system and a method for the treatment of obstructive sleep apnea. The treatment involves monitoring the position of the tongue and/or the force exerted by the tongue and electrical stimulation of the hypoglossal nerve to move the tongue into an anterior position or to maintain the tongue in an anterior position. | 07-25-2013 |
20130190606 | COMBINED QUANTITATIVE MRI AND QUANTITATIVE MRS FOR DIAGNOSIS OF ALZHEIMERS DISEASE AND HIPPOCAMPAL SCLEROSIS - Using both quantitative MRI and quantitative MRS, the inventor demonstrates herein that as age and dementia progress, hippocampal volume (HV), amygdala volume (AV), and NAA/mI ratio all decrease compared to normal controls. The inventor's data also demonstrate herein that NAA/mI vs. total amygdala volume showed a very strong linear correlation, while NAA/mI vs. mean total hippocampal volume had a lesser but still significant correlation. Further, after analyzing the data derived from both quantitative MRI and quantitative MRS methods, the inventor made the surprising discovery that the two tests, when combined, provide significantly improved biomarkers over either alone, and are more effective at early MCI and/or AD diagnosis, as well as HS diagnosis. | 07-25-2013 |
20130150696 | HYBRID MULTIELECTRODE ARRAYS - A method of forming a multielectrode array includes forming an alignment plate having at least two openings, forming an array bottom plate having at least two openings corresponding to the at least two openings of the alignment plate, temporarily fixing the array bottom plate to the alignment plate, inserting one or more probes or array sub-assemblies into the at least two openings, fixing the probes or array sub-assemblies to the array bottom plate, and removing the array bottom plate from the alignment plate to form a multielectrode array. | 06-13-2013 |
20120239111 | APPARATUS AND METHOD FOR TREATING OBSTRUCTIVE SLEEP APNEA - The present invention describes an apparatus, a system and a method for the treatment of obstructive sleep apnea. The treatment involves monitoring the position of the tongue and/or the force exerted by the tongue and electrical stimulation of the hypoglossal nerve to move the tongue into an anterior position or to maintain the tongue in an anterior position. | 09-20-2012 |
20110095759 | METHODS AND APPARATUS FOR PASADENA HYPERPOLARIZATION - The present subject matter relates to methods and apparatus for using hyperpolarization to improve imaging. Am exemplary embodiment, a PASADENA polarizer, is capable of delivering 2.5-5 ml of highly hyperpolarized biological | 04-28-2011 |
20100233089 | IMAGING OF GENETIC MATERIAL WITH MAGNETIC RESONANCE - A method for imaging genetic material such as DNA, RNA and genes by magnetic resonance imaging incorporating hyperpolarization techniques, such as PASADENA or DNP may be used in various app metabolomics, medical diagnosis and genetic research. | 09-16-2010 |
20100092391 | IMAGING AGENTS AND METHODS OF USE THEREOF - Compositions and methods useful in connection with magnetic resonance imaging are provided. Metabolites hyperpolarized by dynamic nuclear polarization are used as reporter molecules in nuclear magnetic resonance (“NMR”) spectroscopy to study metabolic pathways and diagnose disease states. The reporter molecules include hyperpolarized glutamine and hyperpolarized acetate. The invention includes the reporter molecules, compositions including the reporter molecules in pharmaceutically acceptable carriers, methods for studying metabolic pathways that include introducing one or more of the reporter molecules to a mammalian subject and imaging a target substance using NMR spectroscopy, and kits useful in studying metabolic pathways that incorporate one or more of the reporter molecules and instructions for their use. | 04-15-2010 |
20100087896 | APPARATUS AND METHOD FOR TREATING OBSTRUCTIVE SLEEP APNEA - The present invention describes an apparatus, a system and a method for the treatment of obstructive sleep apnea. The treatment involves monitoring the position of the tongue and/or the force exerted by the tongue and electrical stimulation of the hypoglossal nerve to move the tongue into an anterior position or to maintain the tongue in an anterior position | 04-08-2010 |
20090264732 | IMAGING AGENTS AND METHODS OF USE THEREOF - The present invention relates to compositions and methods useful in connection with magnetic resonance imaging. In various embodiments, the invention employs the PASADENA polarization technique to prepare contrast agents that target complementary molecules in the body and/or that are processed through predetermined, natural metabolic pathways. The invention includes methods of using the contrast agents and kits including the same. In one embodiment, a diagnostic and prognostic method relating to Alzheimer's disease is described. Further embodiments relate to medical devices including the contrast agents. | 10-22-2009 |