| GE HEALTHCARE LIMITED Patent applications |
| Patent application number | Title | Published |
|---|
| 20160051710 | Radiolabelling Process - The present invention relates to a novel composition comprising 1-amino-3[ | 02-25-2016 |
| 20160022847 | Radiotracer Compositions - The present invention relates to improved radiotracer imaging agent compositions, which comprises | 01-28-2016 |
| 20160022845 | SYNTHON COMPOSITION - The present invention relates to an improved [ | 01-28-2016 |
| 20150336891 | Zinc Halide Mediated Cyclization Process Leading to Tricyclic Indoles - The present invention relates to a method for the production of tricyclic indole compounds comprising a cyclization step wherein this step is improved over known methods. | 11-26-2015 |
| 20150328344 | Fluorination Process - The invention relates to a process for preparation of a compound of formula (I): | 11-19-2015 |
| 20150320891 | Radioiodinated Fatty Acids - The present invention provides novel radioiodinated fatty acids. Also provided are methods of preparation of said radioiodinated fatty acids from non-radioactive precursors, as well as radiopharmaceutical compositions comprising such radioiodinated fatty acids. The invention also provides in vivo imaging methods using the radioiodinated fatty acids. | 11-12-2015 |
| 20150231249 | 18F-FLUCICLOVINE COMPOSITIONS IN CITRATE BUFFERS - The present invention provides a pharmaceutical composition comprising [ | 08-20-2015 |
| 20150191477 | Fluoride Processing Method - The invention relates to methods for processing [ | 07-09-2015 |
| 20150175553 | PRODUCTION OF 18F-LABELLED COMPOUNDS COMPRISING HYDROLYTIC DEPROTECTION STEP AND SOLID PHASE EXTRACTION - The present invention provides a simplified method for the preparation of | 06-25-2015 |
| 20150139902 | PURIFICATION OF [18F] - FLUCICLATIDE - The present invention relates to a method of purification of [ | 05-21-2015 |
| 20150126708 | RADIOFLUORINATION METHOD - The present invention provides a method of radio fluorination of biological targeting molecules (BTMs) with the radioisotope | 05-07-2015 |
| 20150018541 | STABILISATION OF RADIOPHARMACEUTICAL PRECURSORS - The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose which are used as precursors for production of radiofluoridated sugar derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The method comprises storing the non fluoridated sugar derivative in an organic solvent. The resultant formulations of the non fluoridated sugar derivative and cassettes for automated synthesis apparatus comprising the same are also claimed. | 01-15-2015 |
| 20140377178 | RADIOFLUORINATION METHOD - The present invention relates to a method of labelling biological molecules with | 12-25-2014 |
| 20140364615 | INDOLE DERIVATIVES - An indole-based in vivo imaging agent is provided by the present invention that binds with high affinity to PBR, has good uptake into the brain following administration, and which has good selective binding to PBR. The invention also includes a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said in vivo imaging agent comprising use of said precursor compound, and a kit for carrying out said method. Also provided is a cassette for automated synthesis of the in vivo imaging agent. Further aspects of the invention include a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, and methods for the use of said in vivo imaging agent. | 12-11-2014 |
| 20140303381 | PARTITIONED REACTION VESSELS - In view of the needs of the art, the present invention provides a reaction vessel having two distinct compartments, for separating solid-supported reagents. The present invention also provides a method to perform two step radiochemistry procedures in one reactor in a clean and | 10-09-2014 |
| 20140288317 | ARYLOXYANILIDE IMAGING AGENTS - The present invention provides a novel radiolabelled aryloxyalinine derivative suitable for in vivo imaging. In comparison to known aryloxyalinine derivative in vivo imaging agents, the in vivo imaging agent of the present invention has better properties for in vivo imaging. The in vivo imaging agent of the present invention demonstrates good selective binding to the peripheral benzodiazepine receptor (PBR), in combination with good brain uptake and in vivo kinetics following administration to a subject. | 09-25-2014 |
| 20140256970 | REACTOR FOR MULTI-STEP RADIOCHEMISTRY - A stacked reactor vessel provides two separate reaction vessel compartments for performing chemical reactions and is particularly suited to multi-step chemical reactions and for incorporation into a cassette for automated operation. | 09-11-2014 |
| 20140243555 | METHOD FOR THE SYNTHESIS OF 18F-LABELLED MOLECULES - The present invention provides a method for the synthesis of 18F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present invention provides numerous advantages over the prior art methods. One less purification step is required as compared with known methods. Also, in a preferred embodiment, one less reagent is required as a particular reagent is employed in two different steps. The chemistry process is thereby simplified, the cost of goods is reduced and the burden of validation and documentation of reagents required for GMP clinical production is minimised. | 08-28-2014 |
| 20140238542 | PIERCE AND FILL DEVICE - A pierce and fill connector cap for a vial sealed by an elastomeric septum includes a vial collar and a needle holder. The vial collar body defines a collar aperture to be positioned in overlying registry with the septum of the vial, and the needle holder includes a needle holder body providing a means for holding a pair of elongate needles in registry with the collar aperture. The needle holder body holds at least one needle therein in a bent or deflected orientation and is moveable with respect to the vial collar between a first position spaced from the vial collar and a second position proximate the vial collar, such that the needled held by the needle holder will puncture through the vial septum. | 08-28-2014 |
| 20140235861 | METHOD FOR THE SYNTHESIS OF 18F-LABELLED BIOMOLECULES - The present invention provides a method for the synthesis of | 08-21-2014 |
| 20140140928 | 5HT1A ANTAGONIST USEFUL FOR IN VIVO IMAGING - The present invention provides a novel compound of formula (I) useful for in vivo imaging of 5-HT | 05-22-2014 |
| 20140135531 | PRECURSOR COMPOUNDS AND METHODS FOR MAKING SAME - The present invention relates to a method of obtaining radiopharmaceutical precursors, and in particular precursors to protected amino acid derivatives, which are used as precursors for production of radiolabelled amino acids for use in in vivo imaging procedures, such as positron emission tomography (PET). | 05-15-2014 |
| 20140097078 | DISTILLATION DEVICE AND METHOD - A click chemistry process to be performed with an automated synthesis device using a synthesis cassette includes the steps of performing a chemical reaction in a first vessel at a first elevated temperature, heating the first vessel to a second elevated temperature to cause distillation, delivering a distilled reaction product from the first vessel to a second vessel, performing a click chemistry reaction with the distilled reaction product in the second vessel, purifying the click chemistry product, and formulating a final product from the purified click chemistry product. A cassette and a kit of parts for performing the process are also provided. | 04-10-2014 |
| 20140004041 | TECHNETIUM LABELLED PEPTIDES | 01-02-2014 |
| 20130343990 | RADIOLABELLED OCTREOTATE ANALOGUES AS PET TRACERS - Novel radiotracer(s) for Positron Emission Tomography (PET) imaging are described. Novel radiotracer(s) for Positron Emission Tomography (PET) imaging of neuorendocrine tumors are described. Specifically the present invention describes novel [18F]Fluoroethyltriazol-[Tyr3]Octreotate analogs; in particular those that target somatostatin receptors found on the cell surface of gastroenteropancreatic neuorendocrine tumors. The present invention also describes intermediate(s), precursor(s), pharmaceutical composition(s), methods of making, and methods of use of the novel radiotracer(s). | 12-26-2013 |
| 20130338361 | RADIOFLUORINATION METHOD - Provided by the present invention is a novel method for obtaining an | 12-19-2013 |
| 20130337493 | QUALITY CONTRL DEVICES AND METHODS FOR RADIOPHARMACEUTICALS - A quality control (“QC”) system for PET or SPECT radiopharmaceuticals is disclosed that contains a disposable, no-leakage, self-contained QC cassette, which interfaces with the QC system. The QC system may include a shield that substantially surrounds the cassette such that the area and the cassette are both shielded. The QC cassette may contain shielding also. The QC cassette contains components for conducting one or more QC tests. These components include sensor and devices for performing various QC tests on radiopharmaceuticals. The QC system may contain a number of sub-systems and devices for supporting the QC tests. The QC system may produce a QC report containing the test results. | 12-19-2013 |
| 20130334443 | RADIOPHARMACY AND DEVICES - Components and systems for a PET radiopharmacy include a transport shield for a radioisotope cartridge, a cassette for dispensing from a transport shield, a cassette synthesis platform for a cassette, and a synthesizer shield. | 12-19-2013 |
| 20130324715 | ELUENT SOLUTION - The present invention provides a novel method for the preparation of | 12-05-2013 |
| 20130315824 | RADIOIODINATION METHOD - The present invention provides a novel method of labelling biological targeting molecules (BTMs) of interest with radioiodine. Also provided are functionalised BTMs useful in the method, as well as methods of preparing such functionalised BTMs under mild conditions. | 11-28-2013 |
| 20130287685 | HER2 BINDING PEPTIDES LABELED WITH ALUMINIUM-[18] FLUORIDE COMPLEXED BY NOTA - Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER | 10-31-2013 |
| 20130274507 | PROCESS SIMPLIFICATION FOR PRECURSOR COMPOUND - The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabelled amino acids for use in in vivo imaging procedures such as positron emission tomography (PET). Particularly, the invention relates to a process for preparation of a precursor useful in the preparation of the [ | 10-17-2013 |
| 20130274436 | USE OF ANILINE IN THE RADIOSTABILIZATION OF OXIME LIGATION - A method of radiostabilizing an oxime ligation or imine formation reaction using aniline is described. | 10-17-2013 |
| 20130272961 | RADIOIODINATED GUANIDINES - The present invention provides novel radioiodinated guanidines. Also provided are methods of preparation of said radioiodinated guanidines from non-radioactive precursors, as well as radiopharmaceutical compositions comprising such radioiodinated guanidines. The invention also provides in vivo imaging methods using the radioiodinated guanidines. | 10-17-2013 |
| 20130272960 | RADIOIODINATED FATTY ACIDS - The present invention provides novel radioiodinated fatty acids. Also provided are methods of preparation of said radioiodinated fatty acids from non-radioactive precursors, as well as radiopharmaceutical compositions comprising such radioiodinated fatty acids. The invention also provides in vivo imaging methods using the radioiodinated fatty acids. | 10-17-2013 |
| 20130269825 | MULTI-VIAL DISPENSING - A multi-vial dispensing cassette provides serial dispensement into a plurality of dispense vials. Needle holders may be provided for one or more vials in the cassette and at clip may be incorporated into the needle holder. | 10-17-2013 |
| 20130267730 | PURIFICIATION OF PRECURSOR COMPOUND BY CRYSTALLISATION - The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabelled amino acids for use in vivo imaging procedures such as positron emission tomography (PET). Particularly, the invention relates to a process for preparation of a precursor useful in the preparation of the [ | 10-10-2013 |
| 20130266487 | SHIELDING COLLAR - A shield collar ( | 10-10-2013 |
| 20130261315 | SOLID PHASE EXTRACTION METHOD - The present invention provides a method to prepare an | 10-03-2013 |
| 20130259804 | RADIOTRACER COMPOSITIONS - The present invention relates to improved radiotracer imaging agent compositions, which comprises | 10-03-2013 |
| 20130259803 | RADIOCONJUGATION METHOD - The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to a method of labelling a biological targeting molecule with a radioisotope. The method of the invention is particularly suitable for use with an automated synthesizer apparatus. Also provided are precursors in sterile form, as well as cassettes comprising such precursors useful in the method. | 10-03-2013 |
| 20130251632 | APOPTOSIS PET IMAGING AGENTS - The present invention relates to radiopharmaceutical imaging in vivo of apoptosis and other forms of cell death. The invention provides PET imaging agents which target apoptotic cells via selective binding to the aminophospholipid phosphatidylethanolamine (PE), which is exposed on the surface of apoptotic cells. Also provided are pharmaceutical compositions, kits and methods of in vivo imaging. | 09-26-2013 |
| 20130245307 | PREPARATION OF PET PRECURSOR - The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabeled amino acids for use in in vivo imaging procedures such as positron emission tomography (PET). Particularly, the invention relates to a process for preparation of a precursor of the [ | 09-19-2013 |
| 20130236395 | HETEROCYCLIC COMPOUNDS AS IMAGING PROBES OF TAU PATHOLOGY - Heterocyclic compounds of formula (I) useful as imaging probes of Tau pathology in Alzheimer's disease are described. Compositions and methods of making such compounds are also described. | 09-12-2013 |
| 20130230460 | USE OF CYANINE DYES FOR THE DETECTION OF TAU FOR DIAGNOSIS OF EARLY-STAGE TAUOPATHIES - Radiolabeled compounds useful as diagnostic imaging agents of Tau pathology in Alzheimer's disease are described. Compositions and methods of making such compounds are also described. | 09-05-2013 |
| 20130225903 | PIERCE AND FILL DEVICE - A pierce and fill connector cap for a vial sealed by an elastomeric septum includes a vial collar and a needle holder. The vial collar body defines a collar aperture to be positioned in overlying registry with the septum of the vial, and the needle holder includes a needle holder body providing a means for holding an elongate needle in registry with the collar aperture. The needle holder body being moveable with respect to said vial collar between a first position spaced from the vial collar and a second position proximate the vial collar, such that a needle held by the needle holder will puncture through the vial septum. | 08-29-2013 |
| 20130225829 | FLUORINATION PROCESS - The invention relates to a process for preparation of a compound of formula (I): | 08-29-2013 |
| 20130220484 | ASCEPTIC DISPENSER - A sterile dispense system provides for transfer of a fluid from a disposable fluid-path to a vial without needles piercing the vial stopper, for disconnecting the vial from the disposable fluid-path while keeping integrity of the solution filled into the vial and to enable withdrawing of the solution from the vial. The pressure valve and luer valve are provided in serial connection to a fluid vial to enable clean filling and dispensing from the vial. | 08-29-2013 |
| 20130217908 | STABILISATION OF RADIOPHARMACEUTICAL PRECURSORS - The invention relates to a method for improving stability of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabelled amino acids for use in in vivo imaging procedures such as positron emission tomography (PET). The invention further includes compositions comprising a radiopharmaceutical precursor and a drying agent, and cassettes for automated synthesis apparatus comprising the same. | 08-22-2013 |
| 20130209358 | RADIOTRACER COMPOSITIONS - The present invention relates to [ | 08-15-2013 |
| 20130202530 | NOVEL RADIOTRACER - Novel radiotracer(s) for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of disease states related to altered choline metabolism (e.g., tumor imaging of prostate, breast, brain, esophageal, ovarian, endometrial, lung and prostate cancer—primary tumor, nodal disease or metastases). The present invention also describes intermediate(s), pre-cursor(s), pharmaceutical composition(s), methods of making, and methods of use of the novel radiotracer(s). | 08-08-2013 |
| 20130189186 | APOPTOSIS IMAGING AGENTS BASED ON LANTIBIOTIC PEPTIDES - The present invention relates to radiopharmaceutical imaging in vivo of apoptosis. The invention provides imaging agents which target apoptotic cells via selective binding to the aminophospholipid phosphatidylethanolamine (PE), which is exposed on the surface of apoptotic cells. The radiopharmaceuticals comprise radiometal complexes of chelator conjugates of PE-binding peptides. Also provided are pharmaceutical compositions, kits and methods of in vivo imaging. | 07-25-2013 |
| 20130183240 | IN VIVO IMAGING METHOD FOR CANCER - The present invention provides a method useful in the diagnosis and monitoring of cancer wherein there is an abnormal expression of PBR. The method of the invention is particularly useful in evaluating the severity of the cancer, e.g. PBR expression correlates with cell proliferation rates, metastatic potential, tumour aggressiveness, malignancy progression. The method of the invention can therefore be applied in the determination of likely disease progression and in making an associated prognosis. Furthermore, the method of the invention can find use in determining the likely success of certain therapeutic approaches, or in the evaluation of the efficacy of certain proposed new treatments. | 07-18-2013 |
| 20130183239 | ISOTOPIC CARBON CHOLINE ANALOGS - Novel choline-derived radiotracer (s) having an isotopic carbon for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of disease states related to altered choline metabolism (e.g., tumor imaging of prostate, breast, brain, esophageal, ovarian, endometrial, lung and prostate cancer—primary tumor, nodal disease or metastases). | 07-18-2013 |
| 20130178653 | NOVEL PRECURSOR OF RADIOLABELLED CHOLINE ANALOG COMPOUNDS - The present invention describes intermediate(s), pre-cursor(s), for the preparation of radialabelled choline analogs to be used as radiotracers for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of diseases. | 07-11-2013 |
| 20130177501 | IN VIVO IMAGING METHOD OF MOOD DISORDERS - The present invention provides a method useful in the diagnosis and/or monitoring of mood disorders wherein there is an abnormal expression of PBR. The method of the invention is useful in the differential diagnosis of said mood disorders and other conditions where there is no abnormal expression of PBR but where the symptoms may be similar to those of said mood disorder. | 07-11-2013 |
| 20130149249 | IMAGING TUBERCULOSIS WITH PYRAZINAMIDE CONTRAST AGENTS - The present invention provides novel in vivo imaging agents useful for detecting the presence of mycobacteria using in vivo imaging methods. Also provided by the present invention is a precursor compound useful in the synthesis of the in vivo imaging agents of the invention, and a method to obtain the in vivo imaging agent of the invention using said precursor compound. Methods of in vivo imaging and diagnosis in which the in vivo imaging agent of the invention finds use are also provided. | 06-13-2013 |
| 20130149241 | PEPTIDE RADIOTRACER COMPOSITIONS - The present invention relates to imaging agent compositions comprising radiolabelled c-Met binding peptides suitable for positron emission tomography (PET) imaging in vivo. The c-Met binding peptides are labelled with the radioisotope | 06-13-2013 |
| 20130129626 | IN VIVO IMAGING AGENTS - The present invention relates to the field of medical imaging, and in particular to imaging of disease states associated with the upregulation of the chemokine receptor 5 (CCR5). Imaging agents, precursors and methods are provided which are useful in imaging such disease states. | 05-23-2013 |
| 20130129625 | IN VIVO IMAGING AGENTS - The present invention relates to the field of medical imaging, and in particular to imaging of disease states associated with the upregulation of the chemokine receptor 5 (CCR5). Imaging agents, precursors and methods are provided which are useful in imaging such disease states. | 05-23-2013 |
| 20130101509 | IMAGING AND RADIOTHERAPY METHODS - The present invention relates to in vivo imaging and radiotherapeutic methods and agents which target the enzyme aldehyde dehydrogenase (ALDH) and that are suitable for the in vivo imaging of tumours and treatment of cancer. | 04-25-2013 |
| 20130089501 | SOLID-PHASE FLUORINATION OF BENZOTHIAZOLES - The invention provides a process for the production of an | 04-11-2013 |
| 20130078185 | NITROIMIDAZOLE DERIVATIVES - The present invention provides novel compounds useful in the treatment and diagnosis of mycobacterial infections. Compounds of the present invention have enhanced biological properties as compared to the related known compounds. The present invention also provides a precursor compound useful in the synthesis of certain compounds of the invention, and a method to obtain these compounds using said precursor compound. Methods of treatment and diagnosis in which the compounds of the invention fmd use are also provided. | 03-28-2013 |
| 20130064770 | RADIOLABELED COMPOUNDS AND METHODS THEREOF - The present invention relates to radiodiagnostic compounds, methods of making those compounds, and methods of use thereof as imaging agents for preferably a HA serotonin 5-HT1A receptor for use in PET or SPECT, preferably PET. Compositions comprising an imaging-effective amount of radiolabeled compounds are also disclosed. The present invention also relates to non-radiolabeled compounds, methods of making those compounds, and methods of use thereof to treat various neurological and/or psychiatric disorders. | 03-14-2013 |
| 20130060064 | METHOD AND SYNTHESIS - The present invention provides a method for the preparation of a radiolabeled guanidine derivative, in particular wherein the radiolabeled guanidine derivative is a positron emission tomography (PET) tracer. Certain intermediates useful in said method are also provided, as well as means for carrying out said method in an automated fashion. The method of the invention provides advantages over known methods for the preparation of radiolabeled guanidine derivatives. | 03-07-2013 |
| 20130012718 | PURIFICATION METHOD - A diagnostic imaging agent useful for positron emission tomography (PET) imaging as well as to improved hardware for producing such imaging agents is described. Flutemetamol (18F) Injection for the imaging of b amyloid plaques in the brain and methods and devices for preparing same are described including the automated synthesis and purification of [18F]flutemetamol by means of solid phase extraction (SPE). | 01-10-2013 |
| 20130005984 | 11C-LABELED BENZOPHENONE/BENZOXAZOLE ANALOGUES AS AN INFLAMMATION IMAGING AGENT - A method of preparing novel [ | 01-03-2013 |
| 20120275973 | PURIFICATION METHODS - The invention relates to novel processes for the purification of radiolabelled tracers, using a solid-support bound scavenger group. The general concept being illustrated by the scheme: | 11-01-2012 |
| 20120229804 | BOROSILICATE GLASSWARE AND SILICA BASED QMA'S IN 18F NUCLEOPHILIC SUBSTITUTION: INFLUENCE OF ALUMINUM, BORON AND SILICON ON THE REACTIVITY OF THE 18F- ION - Aluminum, boron and silicon were identified as potential leachables from borosilicate glassware and a silica based QMA during handling of aqueous | 09-13-2012 |
| 20120177569 | LABELLED BIOTIN CONJUGATES - The present invention provides radioactive gallium complexes which comprise DOTA-biotin conjugates, incorporating a linker group. Also described are radiopharmaceutical compositions, and methods and uses of the complexes for in vivo imaging involving pre-targeting with avidin. | 07-12-2012 |
| 20120138520 | SEPARATION PROCESS - The present invention relates to a process for separating a target radiolabelled compound from an impurity, apparatus for performing such a process and a removable cassette for use in such apparatus. Also provided are methods for using the target radiolabelled compound obtained by a method comprising the separating process of the invention. | 06-07-2012 |
| 20120100072 | PET IMAGING OF FIBROGENESIS - The present invention relates to peptide compounds and their use for in vivo imaging using positron emission tomography (PET). More specifically, the invention relates to the use of such peptide-based compounds in a method for the in vivo imaging of liver fibrosis. | 04-26-2012 |
| 20120077967 | NOVEL TECHNETIUM AND RHENIUM COMPLEXES - Novel radioactive technetium and rhenium complexes comprising tripodal ligands are provided by the present invention. In particular, Tc(I) complexes are provided by the present invention. Novel ligands suitable for the formation of the technetium and rhenium complexes of the invention are also provided, as well as radiopharmaceutical compositions comprising said complexes, kits for their preparation. The invention also relates to the use of | 03-29-2012 |
| 20120004423 | SYNTHESIS OF OBTAINING MODIFIED POLYETHYLENE GLYCOL INTERMEDIATES - The present invention provides novel and more efficient synthesis's for obtaining an intermediate in the synthesis of obtaining a protecting group aminoxy PEG linker. | 01-05-2012 |
| 20110293518 | DIAGNOSIS OF WHIPLASH ASSOCIATED DISORDERS (WAD) BY USING PET WITH D-[METHYL-11C]-DEPRENYL (DDE) - Positron Emission Tomography (PET) tracers such as D-[methyl- | 12-01-2011 |
| 20110256055 | APPLICATION OF 99MTC PEPTIDE-BASED COMPOUND AS A BONE MARROW IMAGING AGENT - The present invention relates to methods and materials involved in using peptide-based compounds in bone marrow imaging. More specifically the invention relates to the use of 99mTc peptide-based compounds as targeting vectors that bind to receptors associated with angiogenesis, in particular integrin receptors, e.g. the αvβ3 integrin receptor. Such contrast agents may thus be used for diagnosis of haemolytic anaemia, myeloproliferative disorders, myelofibrosis, selection of biopsy sites, and early detection of skeletal metastatasis as well as detecting avascular necrosis of the femoral heads. | 10-20-2011 |
| 20110196149 | FLUORIDATION METHOD - A method for the fluoridation of an iodonium salt with a fluoride ion source which can be carried out in an aqueous reaction solvent. | 08-11-2011 |
| 20110129419 | IN VIVO IMAGING AGENTS - The present invention relates to the field of medical imaging, and in particular to imaging of disease states associated with the upregulation of the chemokine receptor 5 (CCR5). Imaging agents, precursors and methods are provided which are useful in imaging such disease states. | 06-02-2011 |
| 20110117012 | RADIOLABELED GALLIUM COMPLEXES, METHODS FOR SYNTHESIS AND USE FOR PET IMAGING OF EGFR EXPRESSION IN MALIGNANT TUMORS - The Invention relates to conjugates of formula (III) or (IIIa), or a salt thereof, their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes. | 05-19-2011 |
| 20110070161 | ACTIVE ENANTIOMER - The present invention provides a PET tracer that has improved properties for imaging the peripheral benzodiazepine receptor (PBR) as compared with known such PET tracers. The present invention also provides a precursor compound useful in the preparation of the PET tracer of the invention and methods for the preparation of said precursor compound and said PET tracer. Also provided by the present invention is a radiopharmaceutical composition comprising the PET tracer of the invention. Methods for using the PET tracer and the radiopharmaceutical composition are also provided. | 03-24-2011 |
| 20110033387 | METHOD OF DETERMINATION OF PDH ACTIVITY AND IMAGING MEDIA FOR USE IN SAID METHOD - The invention relates to a method of determination of PDH activity by | 02-10-2011 |
| 20110028751 | PERFLUORO SULFONYL HALIDES AND RELATED SPECIES AS POLYMER SUPPORT MODIFIERS - Activated Supports, support-bound activators, strongly acidic supports, and silylating supports are provided; the activated support having the formula: | 02-03-2011 |
| 20110008261 | METHOD TO PRODUCE HYPERPOLARISED AMINO ACIDS AND AMINOSULPHONIC ACIDS - The invention relates to a dynamic nuclear polarisation (DNP) method for producing hyperpolarised amino acids and amino sulphonic acids and compositions for use in the method. As a sample, an ammonium salt of an amino acid, an ammonium salt of an aminosulphonic acid, a carboxylate salt of an amino acid, a sulphonate salt of an aminosulphonic acid or mixtures thereof is used. | 01-13-2011 |
| 20110008252 | STABALISED 99MTC COMPOSITIONS - The present invention relates to stabilised | 01-13-2011 |
| 20100234611 | Fluorination Process of Anilide Derivatives and Benzothiazole Fluorinate Derivatives as in VIVO Imaging Agents - The invention relates to a process for preparation of a compound of formula (I): R | 09-16-2010 |
| 20100178253 | PEPTIDE IMAGING AGENTS - The present invention relates to labelled cMet binding peptides suitable for optical imaging in vivo. The peptides are labelled with a benzopyrylium dye suitable for imaging in the red to near-infrared region. Also disclosed are pharmaceutical compositions and kits, as well as in vivo imaging methods, especially of use in the detection, staging, diagnosis, monitoring of disease progression or monitoring of treatment of colorectal cancer (CRC). | 07-15-2010 |
| 20100158804 | METHOD FOR THE USE OF [11C] CARBON MONOXIDE IN LABELING SYNTHESIS OF 11C-LABELLED ESTERS AND ACIDS BY SENSITIZED PHOTO-INDUCED FREE RADICAL CARBONYLATION - Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using alkyl/aryl iodides with alcohols or water treated by photosensitizers are provided. The resultant carbon-isotope labeled esters and acids, and pharmaceutical acceptable salts and solvates are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits and method for PET studies are also provided. | 06-24-2010 |
| 20100092387 | Novel Compound Having Affinity For Amyloid - A compound that has affinity with amyloid, exhibits sufficiently rapid clearance from normal tissues, and is suppressed in toxicity such as mutagenicity is provided, which is represented by the following formula (1): | 04-15-2010 |
| 20100040542 | CHELATOR CONJUGATES - The present invention relates to improved chelator conjugates with biological targeting molecules, suitable for forming metal complexes with radiometals. The radiometal complexes, especially with the radiometal | 02-18-2010 |
| 20090311178 | PYRROLINIDIUM DERIVATIVES AS M3 MUSCARINIC RECEPTORS - Compounds of formula (I) in salt or zwitterionic form, wherein R | 12-17-2009 |
| 20090155167 | AUTOMATED METHOD - The present invention provides an automated method for the preparation of | 06-18-2009 |
| 20080293969 | 18F-Labeled Daa Analogues and Method of Labeling These Analogues as Positron Emission Tomography (Pet) Tracers For Imaging Peripheral Benzodiazepine Receptors - Methods for selecting novel DAA analogues for a peripheral type benzodiazepine receptor were labeled with | 11-27-2008 |
| 20080279771 | Novel Imaging Agents for Cancer - A novel imaging agent is described which comprises a semaphorin moiety and an imaging moiety. The novel imaging agent of the invention may be used in the diagnostic imaging of cancer and in particular, for targeting angiogenesis or metaplasia. Further aspects of the present invention presented herein include a method for the preparation of the imaging agent, a pharmaceutical composition comprising the imaging agent of the invention and a kit for the preparation of said pharmaceutical. | 11-13-2008 |
| 20080274052 | RADIOFLORINATION METHODS - The present invention relates to methods and reagents for [ | 11-06-2008 |
| 20080242889 | METHOD FOR THE PRODUCTION OF PYRUVIC ACID - The invention relates to a method for the production of pyruvic acid, in particular pyruvic acid that is | 10-02-2008 |
| 20080226552 | Automated Radiolabelling Method - The present invention provides an automated method for the preparation of | 09-18-2008 |
