Dignity Health Patent applications |
Patent application number | Title | Published |
20160102360 | GENETIC SIGNATURE OF VULNERABILITY TO INHIBITORS OF BASE EXCISION REPAIR (BER) IN CANCER - The invention relates to the identification of genetic signatures and expression profiles that are a part of the Base Excision Repair (BER) pathway, a major DNA repair pathway that modifies base lesions. In one embodiment, the present invention provides a method of determining responsiveness of treatment by BER inhibitors for malignant glioma by determining the presence of a low level of expression of Apex 1, a low level of expression of Apex 2, and a high level of expression of MPG. | 04-14-2016 |
20150354012 | DIAGNOSING IDH1 RELATED SUBGROUPS AND TREATMENT OF CANCER - The invention relates to classification, diagnosis and treatment of cancers. In one embodiment, the present invention provides methods and kits that classify cancers into various subtypes based on expression patterns of AKT pathway components. In another embodiment, the present invention provides methods and kits that diagnose cancer subtypes by evaluating expression patterns of AKT pathway components. In still another embodiment, the present invention provides methods and kits that treat a cancer subtype by administering an alkylating agent or a PI3K/AKT/mTOR inhibitor to a patient. Cancers suitable with various embodiments of the invention include but are not limited to brain tumors, gliomas and GBM. | 12-10-2015 |
20150190410 | USE OF CREATINE AND PHOSPHOCREATINE IN THE TREATMENT OF EPILEPSY AND ALCOHOL ADDICTION - The present invention relates to neurological disorders and treatment of epilepsy, seizures and alcoholism. In one embodiment, the present invention provides a method of treating the frequency of epileptic seizures in an subject by administering a therapeutically effective dosage of a composition comprising creatine and/or phosphocreatine. In another embodiment, the present invention provides a method of treating alcoholism by administering a composition comprising creatine and/or phosphocreatine. | 07-09-2015 |
20150104395 | System and Method for Diagnosis of Astrocytic Brain Tumor - Methods and systems for distinguishing an astrocytic human brain rumor from a non-astrocytic human brain tumor (FIG. | 04-16-2015 |
20150051479 | System and Method for Magnetic Resonance Imaging Using Three-Dimensional, Distributed, Non-Cartesian Sampling Trajectories - A system and method for sampling k-space is provided that substantially simplifies the demands placed on the clinician to select and balance the tradeoffs of a particular selected sampling methodology. In particular, the present invention provides particularly advantageous sampling methodologies that simplify the selection of a particular k-space sampling methodology and, furthermore, the tradeoffs within a particular sampling methodology. | 02-19-2015 |
20140364463 | NICOTINIC ATTENUATION OF CNS INFLAMMATION AND AUTOIMMUNITY - The present invention relates to methods of treating and/or ameliorating the severity of inflammation and autoimmunity in the central nervous system (CNS). In one embodiment, the present invention provides a method of treating multiple sclerosis by administering a therapeutically effective dosage of nicotine, or a pharmaceutical equivalent, analog, derivative, or salt thereof. | 12-11-2014 |
20140221869 | METHOD OF DETECTING NEUROLOGICAL DISEASE - A method and apparatus including identifying a plurality of at least partially repetitive eye movements of a person, the eye movements defined by a first predominantly horizontal saccadic movement that moves the eye away from a fixation target followed by a corrective saccadic movement towards the target shortly thereafter, measuring a vertical component associated with the plurality of eye movements and comparing the vertical component with a predetermined threshold value. | 08-07-2014 |
20140141102 | TRIMEGESTONE (TMG) FOR TREATMENT OF PRETERM BIRTH - As disclosed herein, novel compositions including steroid hormones, such as trimegestone (TMG) and progesterone (P4), provide treatments for term and preterm labor with significant effects on the delay of delivery. Delay and block of delivery occurs when both P4 and TMG are administered late in gestation in pregnant rat and guinea pig animal models. TMG exhibits remarkable drug efficacy, achieving the same inhibition as P4, but at much lower doses. These hereto unknown effects of TMG on the processes of cervical ripening and uterine contraction provide a novel approach for extending pregnancy term, including reducing a likelihood of preterm and/or term labor, along with improved methods of administration. Other diseases and/or conditions may be treated with TMG, such as dysmenorrhea or luteal insufficiency for sustaining pregnancy. | 05-22-2014 |
20140113865 | USE OF PERTUSSIS TOXIN AS A THERAPEUTIC AGENT - The present application relates to the use of a pertussis toxin, and its derivatives, analogs, salts and pharmaceutical equivalents. In one embodiment, the invention provides a method of treating an autoimmune disease by administering pertussis toxin to the individual. In another embodiment, the autoimmune disease is multiple sclerosis. In another embodiment, the invention provides a method of treating a neurodegenerative disease such as Alzheimer's disease or Parkinson's disease by administering pertussis toxin, or a derivative, analog, salt or pharmaceutical equivalent. | 04-24-2014 |
20130231290 | METHODS OF DIAGNOSING AND TREATING NEURODEGENERATIVE DISEASES - The present invention relates to methods of diagnosing, treating and prognosing mental disorders, such as Alzheimer's Disease. In one embodiment, the present invention provides a method of treating Alzheimer's Disease by inhibiting dysfunctional signaling of α7 nAChRs in the medial septum region of an individual. | 09-05-2013 |
20130147394 | METHOD OF DETECTING AND CONTROLLING PERCEPTUAL FLICKER - A method and apparatus are provided for processing light from a light source. The method includes the steps of measuring a predetermined set of characteristics of the light source and detecting flicker when the predetermined set of characteristics exceed a corresponding flicker fusion threshold value. | 06-13-2013 |
20130045987 | NOVEL METHODS OF USE OF TETRAHYDROBERBERINE (THB) - Tetrahydroberberine (THB), isolated from the Chinese herb “ | 02-21-2013 |
20130023505 | METHODS FOR INHIBITING PRETERM LABOR AND UTERINE CONTRACTILITY DISORDERS AND PREVENTING CERVICAL RIPENING - The invention relates to methods and pharmaceutical compositions for inhibiting or preventing preterm birth, inhibiting or delaying cervical ripening, inhibiting myometrial contractility and treating or inhibiting uterine contractility disorders. The methods comprise administering an effective amount of a composition comprising steroid hormones such as soluble progesterone. | 01-24-2013 |
20120252856 | PI3K/AKT PATHWAY SUBGROUPS IN CANCER: METHODS OF USING BIOMARKERS FOR DIAGNOSIS AND THERAPY - The present invention relates to methods of dividing cancer into subgroups based upon Akt pathway gene expression. In one embodiment, the present invention provides a method of diagnosing glioblastoma multiforme (GBM) subtype in an individual by determining the presence of an abnormal expression of an Akt pathway gene cluster and diagnosing the cancer subtype in the individual. | 10-04-2012 |