Council of Scientific and Industrial Research Patent applications |
Patent application number | Title | Published |
20160082421 | NANO Ni-CeO2 CATALYST FOR SYNGAS PRODUCTION AND ITS PREPARATION THEREOF - The present invention relates to Nano Ni—CeO | 03-24-2016 |
20160059217 | Ni-MgO-ZnO Solid Catalysts for Syn Gas Preparation and Process for the Preparation Thereof - The present invention provides a process and catalyst for the production of synthesis gas (a mixture of CO and H | 03-03-2016 |
20150344861 | MUTANTS OF STREPTOKINASE AND THEIR COVALENTLY MODIFIED FORMS - The present invention relates to novel mutants of Streptokinase, its functional fragments and covalently modified forms. Methods are provided for the preparation of the bacterial plasminogen activator protein, Streptokinase its muteins, species variants and their covalently modified variants that are characterized by improved therapeutic properties, such as increased proteolytic stability, extended plasma half-lives, reduced immuno-reactivity and enhanced fibrin clot specificity. The method involves either incorporating additional cysteine residues, or substituting cysteine residues for naturally occurring amino acids into non-essential regions of the protein such that the catalytic activity of the resultant protein remains largely unaltered. These cysteine variants were further modified by covalently attaching a cysteine reactive polymer such as polyethylene glycol (PEG) or sulfhydryl-reactive moieties from a group that includes fluorophore, spin labels or other small conjugates. Disclosed herein are site-specific biologically active conjugates of Streptokinases and its covalently modified variants. | 12-03-2015 |
20150320820 | MICROBIOCIDES FROM PLANT EXTRACTS FOR PROTECTION AGAINST HSV 2 INFECTION - Disclosed herein is a microbicidal composition comprising combination of selected extracts of aerial parts of plants such as | 11-12-2015 |
20150284643 | SINGLE STEP CATALYTIC PROCESS FOR THE CONVERSION OF N-PARAFFINS AND NAPHTHA TO DIESEL RANGE HYDROCARBONS - The present invention discloses a single step catalytic process for the conversion of n-paraffins and naphtha to diesel range hydrocarbons. A bi-metallic Pt—Sn/ZSM-5 catalyst has been developed for the direct conversion of n-heptane as well as naphtha into diesel range hydrocarbons in a single step process. | 10-08-2015 |
20150239821 | PROCESS FOR HYDROGENATION OF OLEFINIC OR ACETYLENIC BONDS - The present invention relates to a process for hydrogenation of olefinic or acetylenic bonds. Further, the present invention relates to a process for selective hydrogenation of olefinic or acetylenic bonds and/including triglycerides using modified metal supported on solid acidic metal oxide catalyst and the process for the preparation thereof. The present invention provides a process for hydrogenation of olefinic or acetylenic bonds using metal supported on solid acid metal oxide based catalyst, at moderate conditions. The present invention also relates to the preparation of metal supported on solid acid metal oxide based catalyst for hydrogenation reactions under mild conditions. | 08-27-2015 |
20150184304 | SELF HEALING ANTI CORROSIVE COATINGS AND A PROCESS FOR THE PREPARATION THEREOF - The present invention provides self-healing anti corrosive coatings comprising composites of conducting polymers, chitosan and silica particles along with epoxy useful for corrosion prevention under highly corrosive medium like 3.5% NaCl. Tafel plots exhibits significantly high corrosion protection efficiency (99.99%) for the epoxy coatings with 2.0 wt % loading of chitosan-polymer composite. The weight loss measurements and salt spray test results clearly exhibit superior corrosion resistance offered by coatings with chitosan-polymer composite. The synergistic interaction between chitosan and polypyrrole in the composite is expected to improve the corrosion resistance properties of the coatings. The SiO | 07-02-2015 |
20150174657 | NANO AGGREGATES OF MOLECULAR ULTRA SMALL CLUSTERS OF NOBLE METALS AND A PROCESS FOR THE PREPARATION THEREOF - The present invention discloses size controlled and stabilized nano-aggregates of molecular ultra small clusters of noble metals and a process for the preparation thereof. The present invention discloses single source multicolor noble metal spherical and uniform nano aggregates of 10-22 nm made up of discrete molecular ultra small noble metal (Nb) nanoclusters (MUSNbNC's) of 1-6 atoms. The MUSNbNC's are capped with amine/DCA (dicarboxy acetone) group acting as a steric and kinetic hindrance for core growth suppressing the further autocatalysis and conversion of super critical nucleus or growth by ripening and formation of nanoparticles and thus having intense fluorescence. | 06-25-2015 |
20150101375 | ANAEROBIC DIGESTION SYSTEM FOR HOUSEHOLD ORGANIC WASTES - The present invention provided a compact anaerobic digestion system to converts household waste biomass materials to methane rich biogas and concentrated compost slurry of about 9 to 40% solids for agriculture soil applications. The horizontal anaerobic digester vessel comprising a horizontal vessel provided with insulation and preferably cylindrical at the bottom, fitted inside of the said vessel is at least one shaft with 4-100 radial or horizontal or diagonal baffles at equal distribution, and attached with a handle or wheel outside the vessel to rotate the shaft from outside, the said vessel being provided with minimum of one port at one end for introducing the raw biomass wastes and another set of ports for discharging stabilized wastes at the opposite end, and having one valve-controlled gas port of above the level of the said port for discharging stabilized wastes, a small hand operated shredder coupled to the digester vessel for shredding/cutting/crushing large and hard solids such as bones to get particles preferably lesser than 10 mm sizes. The waste falls inside the digester and gets mixed slowly while being fed by rotating the handle attached to a shaft having baffles inside the digester. | 04-16-2015 |
20140330020 | WATER SOLUBLE METAL-ORGANIC FRAMEWORKS (MOFS) - An efficient, one step solution state processing of Proton Conducting Homochiral Metal Organic Framework has been achieved by using derivate of amino acid and Zn(II) salt as a MOF constructor. Control over MOF solubility as well as proton conductivity has also been achieved by judicious of the ligand architecture. This invention will lead the way for ease preparation of MOF films for industrial application. | 11-06-2014 |
20140308748 | NOVEL RECOMBINANT STRAIN OF TRICHODERMA USEFUL FOR ENHANCING NUTRITIONAL VALUE AND GROWTH OF PLANTS - The present invention relates to a novel recombinant fungal strain of | 10-16-2014 |
20140284269 | POROUS ABPBI [PHOSPHORIC ACID DOPED POLY (2, 5-BENZIMIDAZOLE)] MEMBRANE AND PROCESS OF PREPARING THE SAME - The present invention relates to a porous ABPBI (phosphoric acid doped poly (2, 5-benzimidazole)) membrane and process of preparing the same. A stable porous ABPBI (Phosphoric Acid Doped Poly (2, 5-benzimidazole)) membrane stable to acids, bases, solvents and autoclaving is disclosed. The membrane finds use for separation of solutes in solution in acids, bases and solvents. | 09-25-2014 |
20140238842 | LASER-INDUCED DISSOCIATIVE STITCHING (LDS) FOR SYNTHESIS OF CARBON AND CARBON BASED NANOCOMPOSITES - Disclosed herein is a process for the synthesis of carbon and carbon based nanocomposites comprising Laser-induced Dissociative Stitching (LDS) from liquid halogen containing aromatic compounds at room temperature. | 08-28-2014 |
20140187639 | Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof - Disclosed are new members of a class of non-lipid small molecule inhibitors which interfere with the interaction between phosphoinositol-3,4,5-triphosphate (PIP3) and pleckstrin homology (PH) domains. These molecules target a broad range of PIP3-dependent signaling events in vitro and exert significant anti-tumor activity in vivo, with improved activity and selectivity toward particular PH domains. The small molecule inhibitors of the invention can be used alone or together with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) or other cancer medicament to treat cancer. Small molecule inhibitors of the invention act synergistically in combination with TRAIL and with other Akt inhibitors in treating cancer. Pharmaceutical compositions and methods for treating cancer are provided. | 07-03-2014 |
20140182158 | SOLAR DRYER WITH ENHANCED EFFICIENCY OF DRYING - The present invention provides an improved solar dryer with improved. The dryer consists of a solar absorber/collector ( | 07-03-2014 |
20140157444 | WDR13 AS A NOVEL BIOMARKER USEFUL FOR TREATING DIABETES AND CANCER - WD-repeat proteins are very diverse, yet these are structurally related proteins that participate in a wide range of cellular functions. WDR13, a member of this family, is conserved from fishes to humans and localizes into the nucleus. To understand the in vivo function(s) of Wdr13 gene, we have created and characterized a mutant mouse strain lacking this gene. The mutant mice had higher serum insulin levels and increased pancreatic islet mass as a result of the enhanced beta cell proliferation. While a known cell cycle inhibitor, p21, was down regulated in the mutant islets overexpression of WDR13 in the pancreatic MIN6 cell line resulted in upregulation of p21, accompanied by retardation of cell proliferation. We suggest that WDR13 is a novel negative regulator of the pancreatic beta cell proliferation. Co-immunoprecipitation experiments showed that this protein interacts with estrogen receptors and various HDACs. We provide evidence to show that WDR13 can regulate estrogen receptors-mediated transcription both in HDAC-dependent and HDAC-independent manner. Given the higher insulin levels, better glucose clearance and the lack of insulin resistance in WDR13 deficient mice, we propose that this protein may be a potential candidate drug target for ameliorating impaired glucose metabolism in diabetes. | 06-05-2014 |
20140137297 | EXPRESSION CONSTRUCT AND PROCESS FOR ENHANCING THE CARBON, NITROGEN, BIOMASS AND YIELD OF PLANTS - The assimilated C and N largely influence plant growth and crop yields. Previous attempts to alter the carbon and nitrogen status of the plants attempted with one or two genes The present invention involves simultaneous co-overexpression of three genes wherein one gene (PEPCase) efficiently capture CO2 whereas the other two encode for enzymes (Asp AT and GS) involved in nitrogen assimilation. The combined effect is the enhancement of carbon and nitrogen status of the plant and the productivity. | 05-15-2014 |
20140073595 | AROMATIC AMIDES AS POTENTIATORS OF BIOEFFICACY OF ANTI-INFECTIVE DRUGS - The present invention relates to an aromatic substituted pentadienoic acid amides and there use in combination of specific amounts of aromatic amides i.e. 4-alkyl-5-(substituted phenyl)-2(E),4(E)-pentadienoic acid amides, its geometrical isomers or their dihydro or tetrahydro derivatives and an anti-infective drug useful in potentiating the bioefficacy of antiinfective drug. The combination of the present invention is useful in the treatment of certain infections and disease at lower concentration of anti-infectives necessary to inhibit the growth of microbial strains and may also find applications in reducing the resistance in microorganisms. | 03-13-2014 |
20140017410 | ELECTROLESS PLATING PROCESS - An electroless plating method for use in metal plating on a porous substrate is disclosed. It uses selective contact of the plating metal salt solution with a reducing solution on the activated surface on or inside the porous substrate. This electroless plating method in the setup is useful for unmanned, automatic operation resulting in almost 100% membrane (pure/composite) with substantially no pinholes or cracks. | 01-16-2014 |
20130323849 | Selective Detection and Analysis of Small Molecules - The invention relates to a material, process and method for the selective analysis of small molecules. Particularly the invention provides a material and a technique for the analysis of small molecules excluding other large molecular weight (MW) analytes. The process involves selective detection of low molecular weight molecules from a sample comprising the steps of placing said sample with SBA-15 particles; and subjecting the same to desorption ionization mass spectrometry, wherein low molecular weight molecules are selectively detected over the higher molecular weight molecules. A kit for the selective analysis of small molecules is also provided. | 12-05-2013 |
20130296579 | PROCESS FOR PREPARATION OF gamma-VALEROLACTONE VIA CATALYTIC HYDROGENATION OF LEVULINIC ACID - An industrially viable process for selective preparation of γ-valerolactone using recyclable non noble metal catalyst is provided. This process provides 80-100% conversion to γ-valerolactone, with selectivity in the range of 80-100%. | 11-07-2013 |
20130274286 | NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NMPRTase) INHIBITOR FOR GLIOMA THERAPY - The present invention relates to identification of a compound which inhibits the enzyme NMPRTase and glioma cancer cell growth and further used for glioma therapy. Pre-B-cell colony enhancing factor 1 gene (PBEF1) encodes nicotinamide phosphoribosyltransferase (NMPRTase), which catalyses the rate limiting step in the salvage pathway of NAD metabolism in mammalian cells. PBEF1 transcript and protein levels have been shown to be elevated in glioblastoma and a chemical inhibitor of NMPRTase has been shown to specifically inhibit cancer cells. Here a structure based drug discovery approach has been reported with an aim to develop novel inhibitors for glioblastoma therapy. Present invention relates to virtual screening using docking of ligands from a large library of 13,000 compounds against NMPRTase as the macromolecular target resulting in short listing of 34 possible ligands, of which six were tested experimentally, using the NMPRTase enzyme inhibition assay and further with the glioma cell viability assays. Of these, two compounds were found to be significantly efficacious in inhibiting the conversion of nicotinamide to NAD, and out of which one compound, 3-amino-2-benzyl-7-nitro-4-(2-quinolyl-)-1,2-dihydroisoquinolin-1-one, was found to inhibit the growth of a PBEF1 over expressing glioma derived cell line U87 also. | 10-17-2013 |
20130263888 | PROCESS FOR THE REMOVAL OF POLYMER THERMOSETS FROM A SUBSTRATE - The present invention relates to a process for the removal of polymer thermosets from the substrates without damaging the substrates. The present invention relates to a process for the removal of polymer thermoset from the substrate retaining the physical and chemical properties of the substrates. The present invention more particularly relates to the use of bio molecules for cleaving polymer thermosets and the process to perform the cleaving. | 10-10-2013 |
20130261322 | PROCESS FOR THE EPOXIDATION OF FATTY ACIDS, THEIR ESTERS AND MIXTURES THEREOF - The present invention relates to an improved process for preparing mono and poly epoxy functionalized fatty acids, their esters and mixtures thereof using solid catalyst i.e. supported group VIb metal oxide, said support comprising silica, alumina and mixtures thereof, optionally with a promoter from group VA wherein the group VIB metal oxide content in the catalyst is 5-20 wt % of support. | 10-03-2013 |
20130225672 | SUBSTITUTED 4-BETA-ACRYLAMIDOPODOPHYLLOTOXIN CONGENERS AS ANTITUMOUR ANTIBIOTICS AND THE PROCESS FOR PREPARATION THEREOF - The present invention provides compounds of general formula (3) as useful potential antitumour agents against human cancer cell lines. The present invention further provides a process for the synthesis of 4β-acrylamidopodophyllotoxin congeners of general formula (3), wherein R and R1 are an aryl group and R is selected from 3,4,5-trimethoxyphenyl or 2-methoxy phenyl and R1 is selected from the group consisting of 4-hydroxy-3-methoxyphenyl, 3-hydroxy-4-methoxyphenyl, 4-fluoro-3-methoxyphenyl, 3-fluoro-4-methoxyphenyl, 2-fluoro-5-methoxyphenyl, 2-fluoro-4-methoxyphenyl, 4-hydroxy-3-nitrophenyl, 4-methoxy-3-nitrophenyl, 4-nitrophenyl, 3-nitrophenyl, 2-nitro phenyl, 4-methoxyphenyl, 3-methoxyphenyl and 4-hydroxyphenyl. | 08-29-2013 |
20130157837 | CONFINEMENT OF NANOSIZED METAL ORGANIC FRAMEWORK IN NANO CARBON MORPHOLOGIES - A hybrid composite of Metal Organic Frameworks (MOF) encapsulated in nanocarbon material, wherein the MOFs are grown inside or outside or both side of nano carbon morphologies of the hybrid composite. Such composites may be prepared by
| 06-20-2013 |
20130118888 | DESALINATION UNIT FOR THE PRODUCTION OF POTABLE WATER FROM SUB-SOIL BRINE - A desalination unit for production of potable water from sub-soil brine including in combination a trapezoidal basin, a condenser, a feed tank, a header, a heat exchanger, a flush valve, a sprinkling system, exhaust heat pipe and water collecting channel; where the exhaust heat pipe is connected to a heat source at one end and to the header at the another end, the header being coupled with the heat exchanger to provide the heat flow, and the heat exchanger being fitted at the inner portion of the trapezoidal basin to heat the sub-soil brine. | 05-16-2013 |
20130115671 | ENZYMES FROM CONIDIOBOLUS BREFELDIANUS AND PROCESS FOR PREPARATION THEREOF - The instant invention relates to a fungus of the | 05-09-2013 |
20130079396 | Anticancer and Tubulin Polymerisation Inhibition Activity of Benzylidene Indanones and Process of Preparing the Same - The present invention relates to benzylidene indanones of general formula 1. The compounds exhibited tubulin polymerisation inhibition. A series of compounds 2-benzylidene 3-(3,4,5-trimethoxyphenyl) indanones having general formulae | 03-28-2013 |
20130066081 | IMIDAZOLONE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENT AND PROCESS FOR THE PREPARATION THEREOF - The present invention provides Chalcone linked Imidazolone compounds of formula A as anti cancer agent against fifty three human cancer cell lines. | 03-14-2013 |
20130065932 | PROCESS FOR THE ISOLATION OF ORGANIC COMPOUNDS USEFUL FOR THE TREATMENT OF CANCER - The present invention relates to two main components, mahanine and mahanimbine (dehydroxy-mahanine) from | 03-14-2013 |
20130053467 | POROUS ABPBI [POLY (2, 5-BENZIMIDAZOLE)] MEMBRANE AND PROCESS OF PREPARING THE SAME - The present invention relates to a porous ABPBI (phosphoric acid doped poly(2,5-benzimidazole)) membrane and process of preparing the same. A stable porous ABPBI (Phosphoric Acid Doped Poly(2,5-benzimidazole)) membrane stable to acids, bases, solvents and autoclaving is disclosed. The membrane finds use for separation of solutes in solution in acids, bases and solvents | 02-28-2013 |
20130052137 | PARA AMINO BENZOIC ACID BASED NANOTUBES - The invention relates to nanotubes and processes for making them and intermediates of a drug moiety or its derivative/s as a structural moiety with side chain/s capable of promoting self aggregation. The side chain/s are mono or a multiple of alkyl chain/s that are substituted or unsubstituted capable of creating self aggregating assemblies. A p-amino benzoic acid (PABA) moiety or derivative as a structural moiety of 4-alkylamido-N-pyridin-2yl-benzamide with a lauric or stearic side chain. 4-alkylamido-N-pyridin-2yl-benzamide and 4-Amino-N-pyridine-2 yl-benzamide, N-(Pyridine-2-yl)-4-dodecanamido-benzamide and N-(Pyridin-2-yl)-4-stearamidobenzamide are intermediates useful for in vivo Conjugation of an active ingredient, illustrated by Rhodamine B. With Rhodamine B as an active ingredient, nano-tubes prepared with lauric side chain, which show red fluorescence and is useful for in vivo tracking. | 02-28-2013 |
20130005009 | PROCESS FOR INTEGRATED PRODUCTION OF ETHANOL AND SEAWEED SAP FROM KAPPAPHYCUS ALVEREZII - The present invention relates to a process for integrated production of ethanol and seaweed biofertilizer from fresh red seaweed, | 01-03-2013 |
20120308485 | PROCESS FOR THE PREPARATON OF NOVEL PORPHYRIN DERIVATIVES AND THEIR USE AS PDT AGENTS AND FLUORESCENCE PROBES - The present invention provides novel porphyrin derivatives represented by the general formula 1 and/or pharmaceutically acceptable derivatives thereof as NIR sensitizers for photodynamic therapeutic and diagnostic, biological and industrial applications. These porphyrin derivatives posses absorption (400-700 nm) and emission (600-750 nm) in the regions where biological chromophores do not absorb and hence are ideal candidates for application as NIR PDT agents and fluorescence sensors for medicinal applications in biology. The substituents like hydroxyl and glycolic units on these dyes render them amphiphilicity thereby improving their solubility in the aqueous media and cellular uptake and localization. These dyes show no toxicity in the dark and are highly selective towards tumor cells and stain nucleus very rapidly. Accordingly, these porphyrin derivatives are extremely useful as NIR PDT fluorescence sensors in photodynamic therapeutic and diagnostic, biological and industrial applications. | 12-06-2012 |
20120302796 | DEPOLYMERIZATION OF LIGNIN USING SOLID ACID CATALYSTS - The invention provides for a process for the depolymerization of lignin in an inert atmosphere to result in substituted phenolic monomer compounds. The process is catalysed by heterogeneous solid acid catalysts and is carried out in batch or continuous mode. | 11-29-2012 |
20120296110 | PROCESS FOR PREPARATION OF PURE ALKYL ESTERS FROM ALKALI METAL SALT OF CARBOXYLIC ACID - The dehydrated alkali metal salts of carboxylic acid are dissolved in the alcohol such as methanol or ethanol or butanol to make their solution in corresponding alcohol. The solution alcohol is further treated with carbon dioxide under pressure or at atmospheric pressure at elevated temperature such as 150 to 200° C. The carboxylic acid gets converted into corresponding alkyl ester and calcium carbonate or sodium carbonate or potassium carbonate as the byproduct. Calcium lactate or Sodium lactate or Sodium acetate or Sodium benzoate or Sodium salicylate as alkali metal salt solution prepared in Methanol or Ethanol or Butanol when treated with carbon di-oxide under pressure or at atmospheric pressure at elevated temperature gets converted to Methyl lactate or Ethyl lactate or Methyl acetate or Methyl benzoate or Methyl salicylate as product. | 11-22-2012 |
20120277297 | Pharmaceutical Composition Useful as Acetylcholinesterase Inhibitors - The present invention relates to pharmaceutical composition comprising the naturally occurring compounds selected from (±) Marrnesin, Columbianetin, Dihydroxanthyletin and substituted coumarin derivatives of 7-allyloxy coumarin, 7-benzyloxy coumarin, 7 -methoxycoumarin, 7-acetyloxy coumarin, 4-methyl-7-hydroxy coumarin and 4-methyl-7-acetyloxy coumarin. The said compositions possess a high degree of acetylcholinesterase inhibitory (AChE) property. | 11-01-2012 |
20120271054 | IMIDAZOTHIAZOLE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF - The present invention provides a compounds 7a-f to 18a-f and 19a-f to 30a-f of general formula A, useful as potential anticancer agents against human cancer cell lines. The present invention further provides a process for the preparation of imidazothiazole-chalcone hybrids 7a-f to 18a-f and 19a-f to 30a-f of general formula A. | 10-25-2012 |
20120253034 | PYRROLO[2,1-C][1,4]BENZODIAZEPINE LINKED IMIDAZO[1,5-A]PYRIDINE CONJUGATES AS POTENTIAL ANTITUMOUR AGENTS AND PROCESS FOR THE PREPARATION THEREOF - The present invention provides a compound of general formula 7, useful as potential antitumour agents against five human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4]benzodiazepine linked imidazo[1,5-a]pyridine conjugates attached through a piperazine moiety and different alkane spacers of general formula 7 | 10-04-2012 |
20120213763 | MUTANTS OF STREPTOKINASE AND THEIR COVALENTLY MODIFIED FORMS - The present invention relates to novel mutants of Streptokinase, its functional fragments and covalently modified forms. Methods are provided for the preparation of the bacterial plasminogen activator protein, Streptokinase its muteins, species variants and their covalently modified variants that are characterized by improved therapeutic properties, such as increased proteolytic stability, extended plasma half-lives, reduced immuno-reactivity and enhanced fibrin clot specificity. The method involves either incorporating additional cysteine residues, or substituting cysteine residues for naturally occurring amino acids into non-essential regions of the protein such that the catalytic activity of the resultant protein remains largely unaltered. These cysteine variants were further modified by covalently attaching a cysteine reactive polymer such as polyethylene glycol (PEG) or sulfhydryl-reactive moieties from a group that includes fluorophore, spin labels or other small conjugates. Disclosed herein are site-specific biologically active conjugates of Streptokinases and its covalently modified variants. | 08-23-2012 |
20120165567 | ONE POT MULTICOMPONENT SYNTHESIS OF SOME NOVEL HYDROXY STILBENE DERIVATIVES WITH ALPHA, BETA-CARBONYL CONJUGATION UNDER MICROWAVE IRRADIATION - The present invention provides a method for the preparation of some novel multiconjugated 2- or 4-hydroxy substituted stilbenes. The method provides one pot multicomponent approach wherein 3-4 step reaction sequences viz. condensation, decarboxylation and Heck coupling occur simultaneously which results in an enhanced yield of desired products and reduced reaction times | 06-28-2012 |
20120070908 | IMMUNO CONJUGATE AND PROCESS FOR PREPARATION THEREOF - Present invention deals with a new immuno-reagent comprising hapten (MPAD)-protein-gold for pesticides detection. The conjugate MPAD-protein-gold competes with the analyte of interest for a finite number of binding sites provided by anti-atrazine antibodies coated on nitrocellulose membrane. The newly developed conjugate has a long shelf life with high stability at 4° C. The dynamic concentration range for standard atrazine solutions shows a linear inhibition (decrease in intensity of color) between 10 ppb to 1 ppm atrazine in water samples. | 03-22-2012 |
20120028295 | SYNERGISTIC COMPOSITION USEFUL AS MICROBIOLOGICAL GROWTH MEDIUM FOR RAPID SCREENING OF PHOSPHATE ACCUMULATING MICROORGANISMS - Screening isolates for phosphate accumulation by quantitative methods requires investment of time, labour and chemicals. There has been paucity of a medium and method for screening phosphate-accumulating microorganisms (PAOs) from the environment. Therefore, a new screening strategy is needed towards isolating effective PAOs in environments with diverse microbial populations and limited organic resources, where it is possible that PAOs are often out-competed by organisms capable of utilising available nutrients more rapidly. In view of these problems, a medium optimal for an efficient screening of P-accumulating microorganisms was developed, which is rapid and allows many PAOs to be screened. Thus, the present invention utilizes Toluidine Blue-O (TBO) a blue coloured dye, which decolorizes due drop in the concentration of phosphate in the medium, as an indicator to quickly evaluate the P-accumulating microorganisms based upon visual observations. Fast decolorization of the dye is an indicator of a superior phosphate accumulating microbe. Therefore, colorimetric reaction using PAM-TBO of the present work was further applied in a novel, extremely high-throughput manner to detect individual microbial isolates, growing on a PAM Petri plate. Adaptation of PAM-TBO assay in screening PAOs in environmental samples for microtitre plate assay enhanced the effectiveness of the assay system efficiently and effectively. | 02-02-2012 |
20120016033 | Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof - Disclosed are new members of a class of non-lipid small molecule inhibitors which interfere with the interaction between phosphoinositol-3,4,5-triphosphate (PIP3) and pleckstrin homology (PH) domains. These molecules target a broad range of PIP3-dependent signaling events in vitro and exert significant anti-tumor activity in vivo, with improved activity and selectivity toward particular PH domains. The small molecule inhibitors of the invention can be used alone or together with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) or other cancer medicament to treat cancer. Small molecule inhibitors of the invention act synergistically in combination with TRAIL and with other Akt inhibitors in treating cancer. Pharmaceutical compositions and methods for treating cancer are provided. | 01-19-2012 |
20120000852 | POLYBENZIMIDAZOLE BASED MEMBRANE FOR DEACIDIFICATION - A membrane comprising polybenzimidazole and aromatic polyester wherein said aromatic polyester is removed is disclosed. The membrane is used for a process of deacidification. | 01-05-2012 |
20110311628 | PULSATILE RELEASE COMPOSITION OF THERAPEUTIC AGENT - A pulsatile release composition which releases the content rapidly after a predetermined lag time comprising a drug containing a core, coated with a pH sensitive graft copolymer. The coating suppresses the drug release at acidic pH prevalent in the stomach and releases it either immediately or after a lag time in the intestinal region. Combinations of multiple numbers of coated and uncoated units provide a sequential pulsatile release of same or different therapeutic agents. | 12-22-2011 |
20110263003 | Microbacterial Peptide Deformylase - The present invention relates to the design of the Antisense-oligonucleotide complementary to the specific region of peptide deformylase gene from | 10-27-2011 |
20110245492 | NOVEL ALLELIC VARIANT OF CYP2C19 ASSOCIATED WITH DRUG METABOLISM - The invention provides methods, PCR primers and sequence determination oligonucleotides for determining a human's capacity to metabolise a substrate of the CYP2C19 enzyme using genetic analysis. | 10-06-2011 |
20110237827 | FAST ISOLATION METHOD FOR THE NATURAL SCAFFOLD URSOLIC ACID FROM DIOSPYROS MELANOXYLON - The present invention relates to a process for the fast isolation of ursolic acid, a highly potent natural scaffold, from the leaves of | 09-29-2011 |
20110184162 | METHOD FOR RAPID ISOLATION OF RNA AND A KIT THEREOF - The present invention relates to a method for rapid isolation of RNA. More particularly, it relates to a method for isolation of RNA using two-solution system. The present invention also relates to a RNA isolation kit. | 07-28-2011 |
20110092585 | IMMUNOMODULATORY PHARMACEUTICAL COMPOSITION AND A PROCESS FOR PREPARATION THEREOF - The present invention provides a novel pharmaceutical composition consisting of a combination of three coumarinolignoids of formula 1, 2 and 3 isolated from the seeds of the plant | 04-21-2011 |
20110076702 | RECOMBINANT 12-KDA PROTEIN USEFUL FOR THE DETECTION OF RESPIRATORY ALLERGIES - The present invention discloses the detection of an important 12K-Da protein having cross-reactivity amongst different prevalent allergenic grasses and fungi can be useful for detection of respiratory allergies. Conventionally, the whole extracts that are used for diagnosis are unable to specifically detect the causative agents. In addition, they are also responsible for additional non-specific sensitivities in patients to other components present in the extract. If a single cross-reactive protein is available, it can replace large number of extracts used for detection of raised IgE levels in allergy by ELISA, immunoblotting and the likes. Further, number of pricks would be reduced and this would benefit both patient and clinicians. It is further realized that production of such a protein by recombinant methods can lead to its availability in pure form and bulk amounts required for routine diagnosis. | 03-31-2011 |
20110059913 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF GASTROINTESTINAL INDICATIONS - The present invention relates to identification of | 03-10-2011 |
20100273861 | MYCOBACTERIAL PEPTIDE DEFORMYLASE - The present invention relates to the design of the Antisense-oligonucleotide complementary to the specific region of peptide deformylase gene from | 10-28-2010 |
20100234289 | INTEGRIN BINDING RGD-LIPOPEPTIDES WITH GENE TRANSFER ACTIVITIES - The present invention provides synthesis of a novel series of cationic lipopeptides with integrin-binding RGD functionalities. The invention also provides high L27 (transformed S1 80, mouse sarcoma cells) cell tropic gene transfer properties of these novel RGD-lipopeptides. Since 127 cell surface contains over expressed integrins, the present class of lipopeptides with integrin-binding RGD ligands are likely to find future applications in targeting anti-cancer genes/drugs to the endothelial cells of tumor vasculatures (possessing over expressed integrins). | 09-16-2010 |
20100228023 | ONE STEP PROCESS FOR THE PREPARATION OF SUBSTITUTED 5, 10-DIHYDRODIBENZO [b,e][1, 4]DIAZEPINE-11-ONES - The present invention provides one step processes for the preparation of substituted dibenzo[b,e][1,4]-diazepine-11-ones by the reaction of substituted isatoic anhydrides with substituted 1,2-phenylenediamines in the presence of aqueous acetic acid. | 09-09-2010 |
20100216121 | Method for the detection of predisposition to high altitude pulmonary edema - The present invention encompasses methods, compositions and kits for the detection of susceptibility to high altitude pulmonary edema in a human subject. The present invention further encompasses isolated polynucleotides for the detection of susceptibility to high altitude pulmonary edema in a human subject. | 08-26-2010 |
20100075868 | METHOD FOR DEVELOPING A TISSUE PROTEOME LIBRARY - The present invention relates to the description of an approach for developing tissue proteome library, which overexpresses all the transcripts (mRNAs) present in a given tissue. Transcripts of interest present in a tissue are normally cloned and overexpressed individually to enable purification of expressed protein and for conducting its structure-function studies. Methods for identification of novel and low abundant transcripts present in tissues are not available, particularly of specimen tissue samples, oocytes and early embryos, for which tissue availability is also a serious limitation. Expression of all the transcripts present in a tissue and comparison of the profile of total expressed protein with that of appropriate controls can be used in identification of all and particularly novel transcripts present in a tissue. This novel proteome library construction approach enables expression of all the transcripts present in a tissue just in one go and analysis of all the expressed proteins employing proteomics and/or other suitable approaches. | 03-25-2010 |
20100068314 | HERBAL COMPOSITION FOR TREATING CD33+ ACUTE AND CHRONIC MYELOID LEUKEMIA AND A METHOD THEREOF - A method of treating CD33+ acute and chronic myeloid leukemia in animals including humans, using fraction nos. 1 and 9 obtained from water:methanol fraction by column chromatography, with ratio of water and methanol ranging between 1:5 to 5:1, wherein said water:methanol fraction is obtained from the polar extract of | 03-18-2010 |
20100016588 | CAFFEINE FRACTION OBTAINED FROM TEA LEAVES AND A METHOD FOR INDUCING AGROBACTERIUM TUMEFACIENS-MEDIATED GENETIC TRANSFORMATION IN PLANTS USING SAID CAFFEINE FRACTION - The present invention relates to a thermolabile caffeine fraction useful for an efficient | 01-21-2010 |
20100016414 | TARGETS FOR HUMAN MICRO RNAS IN AVIAN INFLUENZA VIRUS (H5N1) GENOME - The present invention relates to targets for Human microRNAs in Avian Influenza Virus (H5N1) Genome and provides specific miRNA targets against H5N1 virus. Existing therapies for Avian flu are of limited use primarily due to genetic re-assortment of the viral genome, generating novel proteins, and thus escaping immune response. In animal models, baculovirus-derived recombinant H5 vaccines were immunogenic and protective, but results in humans were disappointing even when using high doses. Currently, two classes of drugs are available with antiviral activity against influenza viruses: inhibitors of the M2 ion channel, amantadine and rimantadine, and inhibitors of neuraminidase, oseltamivir, and zanamivir. There is paucity of information regarding effectiveness of these drugs in H5N1 infection. These drugs are also well known to have side effects like neurotoxicity. Thus there exists a need to develop alternate therapy for targeting the Avian flu virus (H5N1). The present invention addresses this need in the field. | 01-21-2010 |
20090306240 | PROCESS FOR SYNTHESIS OF TELECHELIC URETHANE ACRYLATE UV CURABLE PRE-POLYMERIC MATERIALS - The present invention involves the design of a radiation curable organic pre polymer resin material based on urethane acrylic linkage synthesized from the natural renewable resource cardanol or a derivative thereof, for coating application. These new molecules have a faster and better curing rate compared to the starting renewable resource—cardanol. This is brought about by the hydrogen bonding of the urethane linkage which leads to a pre organization of the molecules in such a way as to bring the cross linkable double bonds closer to each other. The present invention also involves a UV curable formulation of the above mentioned resins along with 2-10 parts by weight of a photopolymerization initiator. The resin, either in a formulation or alone turns into a cross linked film upon photopolymerization in presence of photoinitiator under a UV curable radiation source like a mercury vapor pressure lamp. | 12-10-2009 |
20090240078 | MULTIFUNCTIONAL ALCOHOLS OBTAINED FROM CARDANOL, MULTIFUNCTIONAL ACRYLIC CROSSLINKER AND PENDANT PHOSPHOROUS FLAME RETARDANT DERIVATIVES THEREOF - Multifunctional alcohols, polyols derived from cardanol containing at least 3 hydroxyl groups are disclosed. Such alcohols allow for synthesis of multifunctional crosslinkers such as acrylates, epoxies, and vinyl ethers and flame retardants such as >phosphates. The multifunctional alcohols or polyols can be used in polyurethanes and polycarbonates. The multifunctional crosslinkers can be used in optical coating and waveguide compositions to increase curing speed and crosslink density. The multifunctional phosphates can be used in flame resistant plastics as the highly pendant phosphorus containing phosphate non-halogen flame retardant additives. | 09-24-2009 |
20090221729 | WATER-SOLUBLE MACROMONOMERS CONTAINING TERMINAL UNSATURATION AND A PROCESS FOR THE PREPARATION THEREOF - This invention provides a water-soluble macromonomer having terminal unsaturation obtained by polymerization of monomers in the presence of inclusion complex of chain transfer agent in aqueous system. Hydrophobic chain transfer agent AMSD forms an inclusion complex with methylated cyclodextrin. The complexation enhances its solubility in water and enables the polymerization of water-soluble monomers in aqueous medium. After polymerization cyclodextrin is removed and the macromer with terminal unsaturation obtained can be used further for copolymerization with any vinyl monomer. | 09-03-2009 |
20090221690 | Pharmaceutical Composition for the Prevention/Treatment of Bone Disorders and a Process for the Preparation Thereof - Osteoporosis is one of the major problems in our aging society. Osteoporosis results in bone fracture in older members of the population, especially in post-menopausal women. In traditional medicine, there are many natural crude drugs that have the potential for use to treat bone diseases. So far, there is no report in literature on anti-osteoporosis (bone forming) activity of | 09-03-2009 |
20090203937 | PROCESS FOR PREPARING L- (+) -LACTIC ACID - The present invention provides a commercially viable process for the preparation of highly pure and optically active L-(+)-lactic acid and S-(−)-methyl lactate, in high yield, obtained from esterification of aqueous crude lactic acid solution produced by sugar cane juice fermentation broth and methanol in continuous counter current trickle phase approach or in continuous counter current bubble column manner, using stabilizers and the methyl lactate so obtained is recovered and followed by purification of reasonably pure methyl lactate using reagent mixture such as sodium bi-carbonate, mono-ethanolamine or di-ethanolamine, urea or sodium-bicarbonate, mono-ethanolamine or di-ethanolamine, thiourea to reduce the impurity of dimethyl ester of dicarboxylic such as dimethyl oxalate or di-methyl succinate or methyl ester of mono-carboxylic acid such as methyl pyruvate present as an impurity, so as to get highly pure S-(−)-methyl lactate followed by hydrolyzing highly pure S-(−)-methyl lactate using highly pure lactic acid as a catalyst, using highly pure water as the hydrolysis media and by using pre-treated activated carbon with dilute L-(+)-lactic acid, in batch or continuous mode. This very high pure S-(−)-methyl lactate constitutes an important product having interesting possibilities of application at an industrial level, in pharmaceuticals. Highly pure L-(+)-lactic acid thus obtained is used as an acidulant, as a food additive, for pharmaceutical applications, a monomer for making poly-lactic acid, as a monomer to prepare biodegradable polymer which are useful for manufacturing bags, application films, in the field of sanitary field, and has medical applications. | 08-13-2009 |
20090081322 | Process for the preparation of antioxidant conserve from Indian curry leaves (MURRAYA KOENIGII SPRENG.) - The present invention relates to a simple process for the preparation of safe, environmental friendly, and natural antioxidant conserve of activity ranging between 80-85%, comprising oleoresin from Indian curry leaves ( | 03-26-2009 |
20090068113 | AMPHIPHILIC SQUARAINE DYES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF - The present invention relates to amphiphilic squaraine dyes of the general formula (1) as shown below Formula (1) wherein, R | 03-12-2009 |
20090062474 | NOVEL MULTIFUNCTIONAL ADDITIVE GRAFTED RUBBER AND PROCESS FOR THE PREPARATION THEREOF - The present invention relates to a novel multi functional additive grafted rubber. More particularly the present invention relates to novel grades of rubber and in particular to chemically grafted with cardanol (meta-penta decenyl phenol) and/or its derivatives. Importantly the rubber grades of the invention involve chemically anchored/grafted selective meta alkenyl phenol and/or its derivatives in the backbone of natural or synthetic rubber. Importantly, such rubber variant of the invention have high plasticity, lower Mooney and melt viscosities, better cure properties as compared to conventional virgin natural rubber or natural rubber plasticised with aromatic process oils. | 03-05-2009 |
20090047682 | Method of detecting and predicting bronchodilatory response to beta agonist - Present invention relates to a method for predicting an individual's bronchodilatory response to a β agonist. Present invention particularly relates to the detection of specific allelic variants of the β2AR gene and their use as pharmacogenetic markers towards response to β agonist. | 02-19-2009 |
20080286394 | NOVEL HERBAL FORMULATION AS BRAIN TONIC - The invention provides a novel herbal formulation used to improve the memory and in treatment of amnesia as a brain tonic. Formulation(s) comprises of oleaginous oil of | 11-20-2008 |
20080233103 | Mycobacterial peptide deformylase - The present invention relates to the design of the Antisense-oligonucleotide complementary to the specific region of peptide deformylase gene from | 09-25-2008 |