CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER Patent applications |
Patent application number | Title | Published |
20150292023 | Materials and Methods Related to NSAID Chemoprevention in Colorectal Cancer - Described herein are methods of preventing cancer, treating cancer, inhibiting tumor growth, predicting patient outcomes, optimizing dosage, and monitoring the efficacy of treatment. In particular, certain microRNAs and messenger RNAs are useful indicators of response to NSAID chemoprevention and therapy of patients having Lynch syndrome or hereditary non-polyposis colorectal cancer. | 10-15-2015 |
20140270053 | Method for Consistent and Verifiable Optimization of Computed Tomography (CT) Radiation Dose - A system and a method is disclosed for consistently and verifiably optimizing computed tomography (CT) radiation dose in the clinical setting. Mathematical models allow for estimation of patient size, image noise, size-specific radiation dose, and image quality targets based on digital image data and radiologists preferences. A prediction model estimates the scanner's tube current modulation and predicts image noise and size-specific radiation dose over a range of patient sizes. An optimization model calculates specific scanner settings needed to attain target image quality at the minimum radiation dose possible. An automated system processes the image and dose data according to the mathematical models and stores and displays the information, enabling verification and ongoing monitoring of consistent dose optimization. | 09-18-2014 |
20140205591 | Metabolite Biomarkers for Diagnosis and Prognosis of Pediatric Septic Shock - The present invention provides methods for differentiating a pediatric subject with pediatric septic shock from a healthy pediatric subject or one having sudden inflammatory response syndrome (SIRS). Also provided is a method of predicting pediatric septic shock mortality in a pediatric septic shock patient. | 07-24-2014 |
20140107473 | Laser Guidance System for Interventions - An instrument guide apparatus for use with a surgical or other guided intervention of a patient utilizing a guided instrument is disclosed. The instrument guide apparatus includes at least two line lasers mounted above the patient and generating intersecting planar laser lines along an instrument axis of entry in three-dimensional space above the patient. In an embodiment, the instrument axis of entry in three dimensional space above the patient is received from an imaging apparatus imaging the patient's body at least along a portion of the instrument's axis of entry into the patient. In an embodiment, the instrument axis of entry in three-dimensional space above the patient is a line-of-site for a camera mounted above the patient and controlled by the imaging apparatus. | 04-17-2014 |
20130230542 | ROS-Activated Compounds as Selective Anti-Cancer Therapeutics - Provided are compounds according to the following Formula I: | 09-05-2013 |
20120253176 | Systems and Methods for Debulking Visceral Fat - Systems and methods for debulking visceral fat within a subject, include: providing a focused ultrasound transducer configured to focus ultrasonic power at a focal spot; positioning the focused ultrasound transducer with respect to the subject so that the focused ultrasound transducer is enabled to transfer ultrasonic power into the subject; locating the focal spot of the focused ultrasound transducer with respect to at least one target region containing visceral fat within the subject; and debulking visceral fat within the target region by applying ultrasonic energy from the focused ultrasound transducer with sufficient power to cause the death of visceral fat tissue within the target region. | 10-04-2012 |
20120220531 | SURFACTANT PROTEIN D FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH LUNG INJURY - Surfactant protein D (SP-D) is a member of the collectin family of collagenous lectin domain-containing proteins that is expressed in epithelial cells of the lung. Described herein are methods and compositions for the treatment of disorders associated with lung injury, including methods and compositions for the treatment of bronchopulmonary disorder (BPD). | 08-30-2012 |
20120101042 | Agents and Methods for Tissue Repair and Regeneration - Methods of treating solid organ injuries using compounds that enhance Wnt signalling are described. | 04-26-2012 |
20120041911 | COMPUTER IMPLEMENTED SYSTEM AND METHOD FOR ASSESSING A NEUROPSYCHIATRIC CONDITION OF A HUMAN SUBJECT - A method for assessing a neuropsychiatric condition (such as, but not limited to, a risk that a subject may attempt to commit suicide or repeat an attempt to commit suicide, a risk that terminally ill patient is not being cared-for or treated according to the patient's true wishes, a risk that a subject may perform or repeat a criminal act and/or a harmful act, a risk of the subject having a psychiatric illness, and/or a risk of a subject feigning a psychiatric illness) may include a plurality of steps. A step may include receiving biomarker data associated from an analysis of the subject's biological sample and a step of receiving thought-marker data obtained pertaining to one or more of the subject's recorded thoughts, spoken words, transcribed speech, and writings. A step may include generating a biomarker score associated with the neuropsychiatric condition from the biomarker data. A step may include generating a thought-marker score associated with the neuropsychiatric condition from the thought-marker data. And a step may involve calculating a neuropsychiatric condition score based, at least in part, upon the biomarker score and the thought-marker score. Such method may be operating from one or more memory devices including computer-readable instructions configured to instruct a computerized system to perform the method, and the method may be operating on a computerized system including one or more computer servers (or other available devices) accessible over a computer network such as the Internet or over some other data network. | 02-16-2012 |
20120004205 | IL-13 INDUCED GENE SIGNATURE FOR EOSINOPHILIC ESOPHAGITIS - The present invention concerns methods useful in diagnosing, identifying and monitoring the progression of eosinophilic esophagitis through measurements of gene products induced by IL-13. | 01-05-2012 |
20110294114 | Optimization of determinants for successful genetic correction of diseases, mediated by hematopoietic stem cells - Methods and compositions disclosed herein generally relates to methods of determining minimum hematopoietic stem cell (HSC) chimerism and gene dosage for correction of a hematopoietic disease; in particular, in in vivo models. The invention also relates to modified lentiviral expression vectors for increase a viral titer and various methods for increasing such titers as well as expression vectors capable of enhancing such titers. The invention also relates to CHS4 chromatin insulator-derived functional insulator sequences. The invention further relates to methods for genetic correction of diseases or reducing symptoms thereof, such as sickle cell anemia, a lysosomal storage disease. The invention further relates to a method of improving and/or correcting one or more central nervous system (CNS) abnormalities caused by one or more lysosomal storage disease. The invention further relates to methods of improving titer in transfection-based bioreactor culture production or transfection-based production systems using eukaryotic cells. | 12-01-2011 |
20100105054 | GENE EXPRESSION IN DUCHENNE MUSCULAR DYSTROPHY - Gene expression in peripheral blood from individuals with Duchenne muscular dystrophy (DMD), compared to control individuals, demonstrated differential gene sets that could be used in a method to diagnose DMD, to evaluate effect of DMD therapy, and/or to evaluate propensity to DMD. | 04-29-2010 |
20090269774 | EVALUATION OF EOSINOPHILIC ESOPHAGITIS - A method to evaluate eosinophilic esophagitis based on information in an eosinophilic esophagitis transcriptome. | 10-29-2009 |