Children's National Medical Center Patent applications |
Patent application number | Title | Published |
20160063208 | METHOD AND APPARATUS FOR THE TRICHOTOMOUS IDENTIFICATION OF MORBIDITY, MORTALITY AND SURVIVAL WITHOUT NEW MORBIDITY FROM INTENSIVE CARE - A method for determining a patient risk in according with the present application comprises obtaining patient information for a patient admitted to a medical facility, the patient information including patient descriptive information, diagnostic information and physiological information, determining a patient score according to the physiological information, and simultaneously determining, by circuitry, a patient morbidity risk and a patient mortality risk for the patient according the patient descriptive information, the diagnostic information and the patient score. The determining of the patient score according to the physiological information may further include identifying a numerical value for the patient descriptive information, the diagnostic information and the physiological information, and determining the patient score by computing the numerical values. | 03-03-2016 |
20160058517 | AUTOMATED SURGICAL AND INTERVENTIONAL PROCEDURES - Described herein are an apparatus and methods for automating subtasks in surgery and interventional medical procedures. The apparatus consists of a robotic positioning platform, an operating system with automation programs, and end-effector tools to carry out a task under supervised autonomy. The operating system executes an automation program, based on one or a fusion of two or more imaging modalities, guides real-time tracking of mobile and deformable targets in unstructured environment while the end-effector tools execute surgical interventional subtasks that require precision, accuracy, maneuverability and repetition. The apparatus and methods make these medical procedures more efficient and effective allowing a wider access and more standardized outcomes and improved safety. | 03-03-2016 |
20150359876 | GENERATION OF BROADLY-SPECIFIC, VIRUS-IMMUNE CELLS TARGETING MULTIPLE HIV ANTIGENS FOR PREVENTIVE AND THERAPEUTIC USE - Compositions for T cell-based immunotherapy of HIV, HIV-associated malignancies, HIV-associated viral infections, or other HIV-related complications. Modified T cells that are resistant to invasion or infection with HIV, such as T-cells modified to decrease or eliminate expression of mannosyl-oligosacharide glucosidase enzyme (“MOGS”). Methods for producing such compositions by expanding HIV-specific T cells from different sources to recognize multiple HIV antigens. | 12-17-2015 |
20150290356 | Solution Blow Spun Polymer Fibers, Polymer Blends Therefor and Methods of Use Thereof - Compositions comprising biomedical polymers, and in particular unique blends of poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) are provided. Methods of forming polymer fibers using such compositions and solution blow spinning techniques are also provided, as well as methods of delivering the blow spun polymer fibers onto a surface (e.g., such as tissue for use as a surgical scaffold, sealant or tissue adhesive). | 10-15-2015 |
20150230875 | METHOD AND SYSTEM FOR PROVIDING RECOMMENDATION FOR OPTIMAL EXECUTION OF SURGICAL PROCEDURES - The present disclosure is related to a method and apparatus for providing recommendation for a medical surgical procedure, including acquiring, using circuitry, a plurality of multispectral images representing a portion of an anatomy of a patient, performing image processing on each of the plurality of multispectral images to form a plurality of value maps, each value map identifying aspects of the portion of the anatomy by assigned values, combining the plurality of value maps into a single recommendation map, determining optimal points for performing the medical surgical procedure based on the single recommendation map, and displaying the optimal points for the medical surgical procedure by overlaying the optimal points on an original image of the portion of the anatomy or applying the optimal points to a robotic medical surgical procedure. | 08-20-2015 |
20150230699 | DELIVERY TOOL AND METHOD FOR DEVICES IN THE PERICARDIAL SPACE - The present disclosure is a device and method associated with the delivery of medical devices in the pericardial space using a minimally invasive approach with direct visualization. More specifically, the device can be used to deliver permanent pacing, defibrillation and cardiac resynchronization leads, as well as leadless pacemakers for cardiac rhythm management to the epicardial surface of the heart. A subxiphoid procedure is proposed as a minimally invasive alternative to thoracotomy, while the delivery tool incorporates a camera for direct visualization of the procedure. The tool also incorporates a steerable catheter to provide selective control of the placement and orientation of the medical device in the pericardial space. | 08-20-2015 |
20150223956 | ANCHORED NON-SPHERICAL BALLOON FOR THE TREATMENT OF OBESITY - Described herein are a device and an associated method for treatment of obesity. Specifically, a non-spherical balloon is described that expands inside the stomach to reduce luminal volume. The non-spherical balloon is firmly anchored to the abdominal wall in order to eliminate migration risks. Further, the device inflates in a longitudinal fashion to fill a greater curvature of the stomach, thereby preventing food from contacting the ghrelin-producing cells that stimulate hunger. | 08-13-2015 |
20150150457 | METHOD AND SYSTEM FOR WOUND ASSESSMENT AND MANAGEMENT - Described herein is a system and method for determining characteristics of a wound. The system includes a first imaging sensor that obtains imaging information of a wound area and a second imaging sensor that obtains topology information of the wound area. The system further includes circuitry that designates a representative background portion of the wound area from the imaging information of the wound area, that designates a representative wound portion of the wound area from the imaging information of the wound area, that determines the boundary of the wound portion within the imaging information of the wound area based on the designated representative background and wound portions, that correlates the imaging information and the topology information, that applies the boundary of the wound portion designated within the imaging information to the topology information to designate a mask area, and that determines characteristics of the wound portion within the mask area based on the topology information and the imaging information. | 06-04-2015 |
20150145966 | 3D CORRECTED IMAGING - A system and method for corrected imaging including an optical camera that captures at least one optical image of an area of interest, a depth sensor that captures at least one depth map of the area of interest, and circuitry that correlates depth information of the at least one depth map to the at least one optical image to generate a depth image, corrects the at least one optical image by applying a model to address alteration in the respective at least one optical image, the model using information from the depth image, and outputs the corrected at least one optical image for display in 2D and/or as a 3D surface. | 05-28-2015 |
20150141800 | MANAGEMENT, ASSESSMENT AND TREATMENT PLANNING FOR INFLAMMATORY BOWEL DISEASE - Discussed herein is an image processing device and a corresponding method for assessing inflammatory bowel diseases. A plurality of dynamic MRI sequence of images of a bowel that include peristalsis information of the bowel and static MRI image(s) of the bowel that identify at areas of inflammation, stenosis, and increased mural thickness of the bowel are processed. A displacement of the bowel caused by respiration of the patient is conducted on the dynamic MRI sequences by performing a non-rigid registration. A peristaltic activity is determined by performing motion flow analysis on the dynamic sequences of images. A peristaltic activity of the static MRI image(s) based on a weighted sum of two closest dynamic MRI sequences of images is computed and the static image is combined with the closest dynamic MRI sequence of images by performing a multi-modal registration. | 05-21-2015 |
20150116665 | APPARATUS AND METHOD FOR DETERMINING PHYSIOLOGIC PERTURBATIONS OF A PATIENT - The present disclosure is related to a method and apparatus for determining a physiologic perturbation of a patient including acquiring a video sequence, including a plurality of video frames, of an eye of a patient, selecting at least one parameter of a plurality of parameters including a baseline pupil size, a maximum change in size of a pupil, an average velocity of constriction of the pupil, a maximum velocity of constriction of the pupil, latency of constriction of the pupil, and a velocity of re-dilation of the pupil, determining, using processing circuitry and based on the plurality of video frames, the selected at least one parameter of the plurality of parameters, and determining the physiologic perturbation of the patient based on the determined at least one parameter, where the least one parameter of the plurality of parameters is selected based on which physiologic perturbation of the patient is to be determined. | 04-30-2015 |
20150087969 | SYSTEMS AND METHODS FOR OPTICALLY GUIDED PLACEMENT AND MONITORING OF MEDICAL IMPLANTS - Described herein are systems and corresponding methods to place and further monitor an implanted medical device. The implanted device includes a fluorescent material that is disposed on a portion of a tip of the device. The system also includes a skin patch having one or more infrared light detectors configured to detect light radiation from the fluorescent material on the implanted device located beneath a skin surface of living tissue. The system further includes an image processing module that is configured to construct an image of the implanted device and its surroundings. The processor further registers and analyzes the position of the implanted device and provides an appropriate feedback signal to a monitoring station. | 03-26-2015 |
20150025666 | THREE DIMENSIONAL PRINTED REPLICAS OF PATIENT'S ANATOMY FOR MEDICAL APPLICATIONS - A system and method of creating a 3-dimensional (3D) replica of a patient's anatomy. The method includes acquiring 3D echo images of the patient's anatomy using ultrasound waves, selecting a filter that reduces noise in the 3D echo images, selecting a segmentation algorithm to segment the filtered 3D echo images, selecting at least one additional segmentation algorithm to subsequently segment the segmented 3D echo images, creating a 3D digital model, and outputting the 3D digital model as the 3D replica of the patient's anatomy. The method also includes acquiring other 3D images using MRI/CT scans, creating another 3D digital model, determining a scaling factor to scale the other 3D digital model to correspond to a size of the 3D digital model created using ultrasound waves, combining the 3D digital model and the other 3D digital model, and outputting the combined 3D digital models. | 01-22-2015 |
20140371584 | PATIENT MOUNTED MRI AND CT COMPATIBLE ROBOT FOR NEEDLE GUIDANCE IN INTERVENTIONAL PROCEDURES - A patient mountable robot includes a four link mechanism, three actuators, and a first robot base. The mechanism includes four links that form a closed loop structure. The four links include a base link that includes a spherical joint. The mechanism provides two rotational degrees of freedom about the spherical joint for a needle that is configured to pass through the spherical joint. A first actuator is attached to the mechanism and moves the mechanism to provide the first of the two rotational degrees of freedom. A second actuator is attached to the mechanism and moves the mechanism to provide the second of the two rotational degrees of freedom. The base link of the mechanism passes through the first robot base. A third actuator is attached to the first robot base and linearly translates the base link so that a translational degree of freedom is provided for the needle. | 12-18-2014 |
20140358150 | SURGICAL DISTRACTION DEVICE WITH EXTERNAL ACTIVATION - A surgical distraction apparatus is disclosed. The surgical distraction apparatus includes a tissue distraction device adapted for implantation, the tissue distraction device including a plurality of distraction members, one or more actuators adapted for implantation and operatively coupled to the tissue distraction device, the one or more actuators being configured to drive the tissue distraction device and adjust the alignment of the plurality of distraction members, and an activator adapted to deliver one or more pulses to at least one actuator in the one or more actuators. | 12-04-2014 |
20140328898 | Nano-Liposomal Formulations and Methods of Use - A method for transdermal drug delivery provides for the topical administration of liposome encapsulated nanoparticles. The encapsulated nanoparticles define a nearly monodisperse population of liposomes having an average diameter within a selected size range. Liposomal nanoparticle formulations and methods of treatment therewith are also provided. | 11-06-2014 |
20140303491 | DEVICE AND METHOD FOR GENERATING COMPOSITE IMAGES FOR ENDOSCOPIC SURGERY OF MOVING AND DEFORMABLE ANATOMY - A device for generating composite images of dynamically changing surgical anatomy includes circuitry configured to receive, from an endoscopic imaging device, endoscopic image data. The circuitry is configured to receive, from a tomographic imaging device, intra-operative tomographic image data. The circuitry is configured to receive, from a tracking device, spatial tracking data corresponding to the endoscopic imaging device and the tomographic imaging device. The circuitry is configured to generate real-time dynamically changing composite image data by overlaying, based on the spatial tracking data, the intra-operative tomographic image data on the endoscopic image data. The circuitry is configured to output the composite image data to a display. | 10-09-2014 |
20140271487 | PRUSSIAN BLUE-INSPIRED CONSTRUCTS FOR MULTIMODAL IMAGING AND THERAPY - The invention describes a coordination polymer construct for multimodal imaging and therapy. The construct consists of a core particle made of a novel coordination polymer. The core is coated with a biocompatible coating that stabilizes the particles in a physiological environment. The biocompatible coating can contain attached targeting agents, imaging agents and therapeutic agents or combinations one or more of the targeting, imaging and therapeutic agents. When administered to a subject or a subject-derived specimen, the resulting coordination polymer core-shell construct enables multimodal imaging and therapy, which improves the diagnostic and treatment outcomes of the conditions or diseases where it is administered. The invention describes the novel material, base for the construct, methods for the preparation of the said construct and its use as a multimodal imaging and therapy agent. | 09-18-2014 |
20140222023 | HYBRID CONTROL SURGICAL ROBOTIC SYSTEM - The present disclosure describes a method and system for performing robot-assisted surgical procedures. The system includes a robotic arm system assembly, an end effector assembly, and a hybrid control mechanism for robotic surgery. The robotic arm is a lightweight, bedside robot with a large range of motion, which can be easily manipulated to position endoscope and surgical instruments. The control console is mounted at the distal end of the robotic arm to enable robotic arm to follow operators arm movement, provide physical support, filter out hand tremor, and constrain motion. A universal adapter is also described as an interface to connect traditional laparoscopic tools to the robotic arm. | 08-07-2014 |
20140219526 | DEVICE AND METHOD FOR CLASSIFYING A CONDITION BASED ON IMAGE ANALYSIS - An image analysis device includes circuitry that receives one or more input images and detects a plurality of anatomical landmarks on the one or more input images using a pre-determined face model. The circuitry extracts a plurality of geometric and local texture features based on the plurality of anatomical landmarks. The circuitry selects one or more condition-specific features from the plurality of geometric and local texture features. The circuitry classifies the one or more input images into one or more conditions based on the one or more condition-specific features. | 08-07-2014 |
20140088621 | ANASTOMOSIS CLIPPING TOOL WITH HALF-LOOP CLIP - A tool to fasten tissue or to fasten a prosthetic to tissue includes a gripper to hold one or more tissue portions, a needle, an actuator to drive the needle, a fastener cartridge to store one or more tissue fasteners, a holder cartridge to store one or more holders, and a holder applier to secure one of the holders on one of the fasteners. The actuator drives the needle and the needle pulls a first fastener from the fastener cartridge. The actuator drives the needle through the one or more tissue portions held by the gripper to form a hole in the tissue portions. The needle pulls a leading portion of the first fastener through the hole without a trailing portion of the first fastener being pulled through the hole. The holder applier secures a first holder from the holder cartridge onto the leading portion of the first fastener. | 03-27-2014 |
20140066966 | ENDOPYLORIC TOOL AND METHOD TO TREAT HYPERTROPIC PYLORIC STENOSIS - A low profile gastrointestinal dilation catheter for use in infants includes a catheter tube, a dilation balloon, and at least one anchoring device. The dilation balloon is disposed over the catheter tube and is configured to transition between a compressed state and an expanded state. The at least one anchoring device is configured to prevent migration of the dilation balloon during a transition of the dilation balloon from the compressed state to the expanded state. A method to treat infantile hypertrophic pyloric stenosis (IHPS) is also provided. | 03-06-2014 |
20130339053 | REGIONAL ANALYSIS OF ELECTRONIC HEALTH RECORD DATA USING GEOGRAPHIC INFORMATION SYSTEMS AND STATISTICAL DATA MINING - Population-level health outcomes are observed by using millions of granular, de-identified health elements in electronic patient records. A GIS is integrated with EHR-derived data and uses data mining tools to spatially analyze EHR data, including proper selection of appropriate EHR data fields, retrieving EHR data (using three ubiquitous reporting languages), cleaning, and de-identifying the data. The cleaned EHR data are mapped against multiple geographic/environmental data layers in the GIS, and statistical spatial analyses of the EHR data are performed in a SQL database using data mining tools. | 12-19-2013 |
20130274596 | DUAL-MODE STEREO IMAGING SYSTEM FOR TRACKING AND CONTROL IN SURGICAL AND INTERVENTIONAL PROCEDURES - System and method for tracking and control in medical procedures. The system including a device that deploys fluorescent material on at least one of an organ under surgery and a surgical tool, a visual light source, a fluorescent light source corresponding to an excitation wavelength of the fluorescent material, an image acquisition and control element that controls the visual light source and the fluorescent light source, and captures and digitizes at least one of resulting visual images and fluorescent images, and an image-based tracking module that applies image processing to the visual and fluorescent images, the image processing detecting fluorescent markers on at least one of the organ and the surgical tool. | 10-17-2013 |