CARIDIANBCT, INC. Patent applications |
Patent application number | Title | Published |
20120145619 | INTEGRATED DISPOSABLE SET FOR AN APHERESIS SYSTEM - An integrated pre-connected apheresis disposable set for separating plasma from blood in a separation vessel and further separating the separated plasma into desired plasma proteins in a plasma separator fluidly connected to the separation vessel to receive the separated plasma. | 06-14-2012 |
20120089930 | Customizable Methods and Systems of Growing and Harvesting Cells in a Hollow Fiber Bioreactor System - Embodiments described herein generally relate to methods and systems for customizing protocols for use with a cell expansion system. Through a user interface, a user may create a custom task for loading, growing and/or harvesting cells. A custom task may comprise one or more steps, in which a user may add or omit steps, as desired. Data may be entered for settings associated with a custom task, in which embodiments provide for such data to be entered each time the custom task is performed. In another embodiment, the settings for a custom task may be configured, in which such settings may be stored and retrieved upon selection of the custom task. Customization and configuration of a custom task may occur using a diagram view of the cell expansion system, in which process settings are associated with graphical user interface elements. | 04-12-2012 |
20120088224 | Methods and Systems of Growing and Harvesting Cells in a Hollow Fiber Bioreactor System with Control Conditions - Embodiments described herein generally relate to methods and systems for using an air removal chamber as a control for a process in a cell expansion system. The air removal chamber may be mounted on a fluid conveyance assembly for use with the system. Fluid is pumped into a fluid containment chamber of the air removal chamber, in which the level of fluid in the fluid containment chamber may be monitored through the use of one or more sensors. The sensors are capable of detecting air, a lack of fluid, fluid, and/or a gas/fluid interface, e.g., an air/fluid interface, at measuring positions within the air removal chamber. Protocols for use with the system may include one or more stop conditions. In an embodiment, the stopping of a process is automated based on the detection of air, a lack of fluid, and/or a gas/fluid interface in the air removal chamber. | 04-12-2012 |
20120086657 | Configurable Methods and Systems of Growing and Harvesting Cells in a Hollow Fiber Bioreactor System - Embodiments described herein generally relate to methods and systems for configuring settings of a cell expansion system including a bioreactor. Through a user interface, a user may configure display settings, system settings, and settings associated with protocols for loading, growing and/or harvesting cells. In configuring settings for protocols and associated processes, a diagram view or window of the cell expansion system is displayed in embodiments. The diagram view displays the process settings as graphical user interface elements. Settings available for configuration are enabled for selection in the diagram view. The diagram view allows the user to visualize the settings available for task configuration and to configure enabled settings. Configured settings are stored and capable of retrieval for subsequent execution or modification of the applicable protocol. | 04-12-2012 |
20120015795 | CENTRIFUGE FOR PROCESSING BLOOD AND BLOOD COMPONENTS - The present invention relates generally to the field of extracorporeal blood processing methods and apparatus which are particularly useful in blood component collection, and more specifically, the present invention relates to methods and apparatus for centrifugally separating buffy coat that reduce the surface available for separated buffy coat components to sediment on by varying the radius of the product collection bag. | 01-19-2012 |
20120015794 | Method for Optimizing Spin Time In a Centrifuge Apparatus for Biologic Fluid - A method for controlling a centrifuge blood component separation system for separating components of a blood product, the separation system comprising a centrifuge and a separation bag and at least one transfer bag. The method comprises selecting a nominal hematocrit value such that an actual hematocrit value is expected to be less than said nominal hematocrit; centrifuging a separation bag containing a volume of composite liquid so as to cause the sedimentation of at least a first component and a second component; transferring some of the first component to a first transfer bag; detecting time of passage of a red blood cell interface at a pre-selected location in the separation bag; and adjusting a predicted processing time based on the time of passage of the red blood cell interface. | 01-19-2012 |
20120010062 | BLOOD PROCESSING APPARATUS AND METHOD WITH AUTOMATICALLY ADJUSTED COLLECTION TARGETS - A method and apparatus for collecting a maximum amount of platelets for a selected blood separation procedure without collecting excess platelets above those required for a selected platelet product, whether that product was one unit of platelets, two units of platelets (a double platelet), or more. The method and apparatus will continue to adjust the platelet yield target for platelet collection throughout the procedure without operator intervention, unless the selected procedure cannot be completed successfully, and the operator is required to select another allowed procedure. | 01-12-2012 |
20110312481 | Multi-Unit Blood Processor With Isolated Valves for Radio Frequency Sealing - An apparatus for separating at least two discrete volumes of a composite liquid into components, comprising a valve design that facilitates loading and unloading of sets of blood bags. The valves comprise a jaw mounted on a shaft, the jaw being adapted to apply radio frequency energy to seal a tube, a stepper motor section, and at least two position sensors. The valve sections are mounted on an upper plate, and the stepper motor sections are mounted on a lower plate. A main radio frequency coil is selectively electrically coupled to each of the valves through a multiplexing switch. | 12-22-2011 |
20110301012 | Multi-Unit Blood Processor with Volume Prediction - Method and Apparatus for predicting the volume of a component separated from a composite fluid by predicting the volume of the composite fluid from sensed pressure and predicting the volume of other separated components from sensed movement of the other components to collection bags. | 12-08-2011 |
20110294641 | Apparatus and Method for Operating a Multi-Unit Blood Processor with Varying Units of Blood - A multi-unit blood processor uses a hydraulic bladder system to express blood components out of whole blood bags and into collection bags. A dummy whole blood bag, containing an inert fluid, may be placed in a processing location. The dummy bag has characteristics that allow the blood processor to recognize the presence of the dummy bag. An opaque feature may be detected by a photo sensor. A radio frequency sensor may be used to detect a passive radio frequency emitter on the dummy bag. The dummy bag may have a bar code label identifying it as a dummy bag. The blood processor will not attempt to process the dummy bag. | 12-01-2011 |
20110294640 | Multi-Unit Blood Processor With Temperature Sensing - Method and apparatus for centrifugal blood component separation including temperature sensing in each of a plurality of separation cells. The temperature of unit of bloods over time is recorded. If the temperature of any of the units exceeds a pre-determined maximum, portions of the blood separation device may be cooled. A controller may determine which of the units to process first, generally proceeding from the warmest unit to the coolest. The order of unit processing may be changed during processing. The detected temperature may be used to calibrate a pressure sensor used to predict the volume of a component separated from a composite fluid by predicting the volume of the composite fluid from sensed pressure and predicting the volume of other separated components from sensed movement of the other components to collection bags. | 12-01-2011 |
20110275056 | Method and Apparatus for Controlling a Cell Expansion Apparatus - A method for controlling cell expansion comprising conducting a fluid containing cellular matter into a cellular growth area; providing oxygenated fluid to said cellular growth area to maintain conditions conducive for cell growth in said cellular growth area; monitoring inflow and outflow conditions; determining rates of change (first derivative) for selected conditions and calculating cell numbers therefrom; determining a rate of change of a rate of change (second derivative) for the selected conditions and calculating a predicted process time; and terminating the growth process when adequate cell numbers have been produced and an apparatus for performing the method. | 11-10-2011 |
20110269614 | Blood Processing Apparatus with Robust Outflow Process Control - A density centrifuge blood processing system comprising a separation chamber rotating about a central rotation axis, the separation chamber having an outflow passage, a light source in optical communication with the density centrifuge blood processing system, the light source providing an incident light beam for illuminating an observation region and a viewing region on the outflow passage, a first detector for the separation chamber to detect light from the observation region, a second detector for the outflow passage, a computational apparatus distinguishing one or more phase boundaries in the observation region and distinguishing fluid composition in the viewing region as a function of light intensity received from the viewing region, and a controller regulating speed of at least one pump or of said separation chamber in response to signals from the computational apparatus. | 11-03-2011 |
20110263019 | Method of Reseeding Adherent Cells Grown in a Hollow Fiber Bioreactor System - This invention is directed to methods of directly reseeding harvested adherent cells grown in a hollow fiber bioreactor. Also disclosed is a novel harvest media for use in directly reseeding adherent cells into a hollow fiber bioreactor. | 10-27-2011 |
20110224064 | BLOOD PROCESSING APPARATUS WITH CELL SEPARATION CHAMBER WITH BAFFLES - A disposable blood separation set of a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber a baffle within a separation area. The baffle may have a plurality of vanes with openings therein. A protruding inlet may have a frustro-conical inner surface that slants radially outwardly from an inlet to a mouth of the protruding inlet. A circumferential well may surround the protruding inlet. | 09-15-2011 |
20110220290 | Heat Weld Tubing Connectors - The present invention provides thermoplastic tubes, thermoplastic melting plates, thermoplastic tube connecting apparatus, and methods for using the same. | 09-15-2011 |
20110201487 | Blood Processing Apparatus with Optical Reference Control - A density centrifuge blood processing system with automatic two-dimensional optical control of fluid separation by observing fluid characteristics in observation regions. The location of the regions is determined by monitoring an optical reference. Points representing edges of an optical reference are measured and lines are computed through the points. An error measurement is calculated for each line. If the error is too large, the image is abandoned. One of the lines is selected as a referent line. A new line is calculated orthogonal to the referent line. The error function is again computed for the dependant line. If the error exceeds a selected maximum, the frame is discarded. A transformation function translates data points from an (r, s) domain derived from measurements of the edges into an (x, y) domain used to identify pixels in the observation areas. | 08-18-2011 |
20110159584 | METHOD OF LOADING AND DISTRIBUTING CELLS IN A BIOREACTOR OF A CELL EXPANSION SYSTEM - A method of distributing a plurality of cells in a bioreactor of a cell expansion system includes manipulating an orientation of the bioreactor such that a net impulse due to gravity acting on the plurality cells in the bioreactor is reduced. One method includes (a) rotating the bioreactor at an angular velocity ω about an axis of rotation and through an angular displacement θ, the bioreactor rotating from a first orientation to a second orientation; (b) holding the bioreactor still at the second orientation for a first period of time t | 06-30-2011 |
20110155256 | Air Removal Chamber for a Cell Expansion System and Method of Use Associated Therewith - A cell expansion system includes an air removal chamber to provide a bubble trap so that air and/or gas bubbles do not enter the bioreactor of the cell expansion system. The air removal chamber includes a pair of ports situated at the bottom of the air removal chamber. An entrance port allows fluid to enter the air removal chamber, and an exit port allows fluid to exit the air removal chamber. In one embodiment the air removal chamber forms an element of a premounted fluid conveyance assembly for use with a cell expansion machine. | 06-30-2011 |
20110152740 | METHODS AND APPARATUS FOR COLLECTION OF FILTERED BLOOD COMPONENTS - A method and apparatus for red blood collection and filtration is provided wherein a red blood cell collection assembly provides for leukoreduction filtration concurrent with or soon after the red blood cell separation and collection procedure. After red blood cells have been collected, an unwanted blood component, e.g., buffy coat, is diverted into the red blood cell collect line. Operation of a peristaltic pump engaging pump loop allows insertion of a pre-determined quantity of buffy coat into the collect line. The buffy coat can therefore push red blood cells out of the filter and into a collect bag without diluting the collected red blood cells. Alternatively, gravitational force may be used to allow the unwanted blood component to displace red blood cells out of the filter. | 06-23-2011 |
20110152055 | METHOD AND APPARATUS FOR EXTRACTING PLATELETS WITH REDUCED PLASMA CARRYOVER - A centrifugal blood processing apparatus comprising a centrifuge rotor, a separation chamber, a tubing set for conducting blood components and fluids and a method for controlling the blood processing apparatus comprising separating a blood component in a separation chamber; flowing the blood component out of the separation chamber and into a concentration chamber; concentrating the blood component in the concentration chamber; and flushing the blood component out of the concentration chamber. The method further comprising simultaneously flowing a solution, such as a wash solution or PAS, into the concentration chamber between the separation chamber and the concentration chamber. | 06-23-2011 |
20110143905 | System for Blood Separation with Shielded Extraction Port and Optical Control - A centrifugal blood separation system comprising a rotor, a light source, an optical sensor, a control system, a separation vessel, and an optical cell on the separation vessel. The optical cell has a first extraction port extending radially outwardly into the optical cell, a red blood cell extraction port downstream from the first extraction port and extending into the optical cell beyond the first extraction port; and a dam between said first extraction port and said red blood cell extraction port, having an upper edge and a lower edge, wherein the first extraction port and the red cell extraction port are radially between the upper edge and the lower edge of the dam. Also, a first extraction port having a bore having a first diameter, a lumen having a second diameter smaller than the first diameter, and a frustro-conical passageway coupling the bore to the lumen. | 06-16-2011 |
20110136650 | Multi-Unit Blood Processor With Progressively Centered Chambers - An apparatus for separating at least two discrete volumes of a composite liquid into at least a first component and a second component, comprising a well provided on a rotor near the axis of rotation for receiving a relatively rare blood component, such as mesenchymal stem cells (MSC), or for receiving a fluid that can be used multiple times, such as a washing solution. The well is placed radially outwardly from the axis of rotation and radially inwardly from cavity, which receives bags containing blood or another biologic fluid. The well is placed in a low centrifugal force region relative to the position of the cavity. | 06-09-2011 |
20110136646 | Multi-Unit Blood Processor And Bag Set with Asymmetric Manifold - An apparatus for separating at least two discrete volumes of a composite liquid into at least a first component and a second component, comprising an asymmetrical junction or manifold in the blood bag and tubing set inhibits errors when the bags and tubes are loaded into the device. | 06-09-2011 |
20110136645 | Multi-Unit Blood Processor With Rotating Valves - An apparatus for separating at least two discrete volumes of a composite liquid into at least a first component and a second component, comprising a valve design that facilitates loading and unloading of blood bags and associated tubing and bag sets. The valves comprise a rotating head, mounted on a shaft, which assumes a “load” position. The head pivots to an “open” position, which secures the tube in its designated location, but which maintains an open lumen through the tube. When the head is in a “closed” position, blood components cannot flow through the tube. The valve apparatus comprises means for maintaining a constant pressure on the tube and contact with the tube as the tube is melted and sealed. | 06-09-2011 |
20110028295 | Apparatus for Separating a Composite Liquid Into At Least Two Components - An apparatus for separating blood into blood components using a separation vessel satellite bags mounted on a centrifuge rotor and a balancing assembly for the centrifuge to compensate for changes to the center of gravity. | 02-03-2011 |
20110021333 | Blood Processing Apparatus with Incipient Spill-Over Detection - A density centrifuge blood processing system comprising a separation chamber rotating about a central rotation axis, the separation chamber being coupled to an elutriation chamber, a first detector for the separation chamber to detect light from an observation region, a computational apparatus distinguishing at least two regions in the observation region and distinguishing incipient spill over of cellular components out of the elutriation chamber as a function of light intensity received from the at least two regions in the separation chamber, and a controller regulating speed of at least one pump or of the separation chamber in response to signals from the computational apparatus to avoid spill over. | 01-27-2011 |
20110003675 | Apparatus and Method for Automatically Loading Washing Solution In A Multi-Unit Blood Processor - A method and apparatus for separating at least two discrete volumes of a composite liquid into at least a first component and a second component and automatically washing at least one component on a centrifuge rotor. The method comprises transferring a wash solution from a wash solution bag on the rotor into a separation bag; mixing the wash solution and a separated blood component; separating and then transferring the sedimented wash solution into a wash solution discard bag on the rotor. The separated blood component may be washed a plurality of times. A disposable set of tube-connected bags comprises a primary bag, initially containing whole blood, connected to at component bags for receiving plasma or platelets and also connected to a wash solution bag and a wash solution discard bag. The disposable set may further comprise a red blood cell collection bag connected through a filter. | 01-06-2011 |
20100273627 | Method for Separating Discrete Volumes of A Composite Liquid - A method for separating at least two discrete volumes of a composite liquid into at least a first component and a second component, comprising centrifuging at least two separation bags containing two discrete volumes of a composite liquid respectively, so as to separate therein the first and second components; transferring at least one fraction of a first separated component from the separation bags into satellite bags connected thereto respectively; detecting a characteristic of a component at determined location in each separation bag; and stopping transferring the at least one fraction of the first component from each separation bag into the first satellite bag connected thereto, upon detection of the characteristic of a component at the determined location. | 10-28-2010 |
20100267538 | Methods and Apparatus for Hemolysis Detection in Centrifugal Blood Separator - A centrifugal blood processing apparatus comprising a centrifuge rotor, a separation chamber, a tubing set for conducting blood components and fluids and having an inlet line, and an outlet line. Apparatus tests flow conditions using a red light-green light sensor to detect non-recoverable hemolysis during priming by identifying a high R/G ratio, preferably a ratio of greater than or equal to fifty (50), prior to the beginning of the first return of blood components to a donor followed by identifying a R/G ratio at least as great as one and one tenth (1.1) together with a green signal less than a predetermined value, preferably less than or equal to one thousand (1000) reflectance units. If these conditions are detected, an alarm is given and the apheresis procedure is discontinued. | 10-21-2010 |
20100210441 | Apparatus And Method For Separating Discrete Volumes Of A Composite Liquid - An apparatus for separating at least two discrete volumes of a composite liquid into at least a first component and a second component comprises a centrifuge, which comprising a rotor having a rotation axis, comprising at least one separation cell, for containing a separation bag containing a isolated volume of composite liquid; a satellite cell for containing a satellite bag, and a fluid path between the separation cell and the satellite cell, the path being radially closer to the rotation axis than both the separation cell and the satellite cell and axially above both the separation cell and the satellite cell. | 08-19-2010 |
20100210016 | ROTATION SYSTEM FOR CELL GROWTH CHAMBER OF A CELL EXPANSION SYSTEM AND METHOD OF USE THEREFOR - A system and method for rotating a cell growth chamber of a cell expansion system includes a rotatable member for engaging a chamber coupling attached to the cell growth chamber. The rotatable member includes an independently operable mechanism for engaging a rotatable fitting associated with the chamber coupling. In at least one embodiment, the chamber coupling is selectively rotatable by turning the rotatable member, thereby rotating the cell growth chamber around a first axis. The cell growth chamber is also selectively rotatable around a second axis by turning the rotatable fitting associated with the chamber coupling. Other novel aspects include a way of attaching the cell growth chamber to the shaft assembly, and a new tube routing clip. | 08-19-2010 |
20100160137 | Blood Processing Apparatus with Air Bubble Detector - A centrifuge for separating blood and blood components having a blood processing vessel mounted on a rotor of a centrifuge. A sensor in the outflow race of a return peristaltic pump detects air bubbles in the fluid within a return loop. The sensor may be a sonic sensor, a sonic pulse echo sensor, or capacitive plates. A pre-determined minimum bubble size or sizes or a cumulative volume may be selected, and the device operator may be warned only of the existence of bubbles that exceed a certain size or of a cumulative volume of bubbles, or the blood donation procedure may be stopped if a bubble exceeds a certain critical size or if a pre-determined volume of bubbles over a certain period or volume of fluid is exceeded. | 06-24-2010 |
20100160134 | Blood Processing Apparatus with Digitally Controlled Linear Voltage Regulator for Optical Pulses - The invention relates to apparatus for controlling the processing of blood into blood components, particularly components for stroboscopic LED light sources for centrifuges. A digital control circuit controls a high amperage linear voltage regulator. The voltage regulator charges a capacitor bank, which in turn powers LED light sources. The digital control circuit comprises an N-channel switched mode FET. The switched mode FET receives a pulsed digital signal from the microprocessor controlling the blood processing apparatus. A by-pass resistor in parallel with the FET allows most of the current to flow past the FET, thus minimizes heating of the FET. The performance of the FET, therefore, remains stable despite extended use of the apparatus. | 06-24-2010 |
20100144037 | Disposable Tubing Set for Use with a Cell Expansion Apparatus and Method for Sterile Sampling - A disposable apparatus for cell expansion, having at least one bioreactor. The bioreactor has a cellular growth area and a supply area, the cellular growth area being separated from said supply area by a membrane. A fluid recirculation path in fluid communication with the cellular growth area allows for hermetically removing a sample containing cellular matter. This may comprise an elongated tube, or a plurality of parallel tube segments. The parallel tube segments have inflow ends and outflow ends, and the inflow ends are joined at a first common juncture and the outflow ends are joined at a second common juncture. The common junctures may comprise valves. | 06-10-2010 |
20100132512 | Frangible Opener - A hand held opener for opening a frangible closer comprising a handle adapted to be gripped by an operator, a motion actuator operatively connected to the handle, a first shaft connected to the motion actuator, a second shaft connected to the motion actuator, a first gripper portion on the first shaft adapted to grip the frangible closer in a first location, and a second gripper portion on the second shaft adapted to grip the frangible closer in a second location wherein the motion actuator provides reciprocal movement to the shafts to rotate the frangible closer in one direction and to rotate the frangible closer in a direction opposite the first direction. | 06-03-2010 |
20100105138 | PREMOUNTED FLUID CONVEYANCE ASSEMBLY FOR CELL EXPANSION SYSTEM AND METHOD OF USE ASSOCIATED THEREWITH - A premounted fluid conveyance assembly for use with a cell expansion machine comprises a tubing-organizer and a fluid conveyance system. The fluid conveyance system is at least partially attached to the tubing-organizer, and the fluid conveyance system comprises an oxygenator or gas transfer module, a length of tubing and a bioreactor all fluidly interconnected. The premounted fluid conveyance assembly is adapted to be detachably-attached to the cell expansion machine. Accordingly, after a premounted fluid conveyance assembly is used, it is removed from the cell expansion machine by disengaging it from the cell expansion machine. Thereafter, another premounted fluid conveyance assembly can be attached in place of the previously used premounted fluid conveyance assembly. | 04-29-2010 |
20100081985 | Platelet Additive Solution For Leukoreducing White Blood Cells In Apheresed Platelets - This invention relates to a method of reducing residual white blood cells in an apheresed platelet product. The method includes the steps of adding to the platelet product a solution comprising sodium chloride and magnesium and inducing degradation of the residual white blood cells. | 04-01-2010 |
20100081196 | Method for Separating a Volume of Whole Blood Into At Least Three Components - A method for separating a volume of whole blood contained in a separation bag into at least three components comprising centrifuging the separation bag so as to separate therein a first inner layer comprising plasma, a second intermediate layer comprising platelets, a third intermediate layer comprising lymphocytes, monocytes and granulocytes and a fourth outer layer comprising red blood cells, transferring, into a plasma component bag connected to the separation bag, a plasma component and transferring into a mononuclear cell component bag a mononuclear cell components. | 04-01-2010 |
20100078392 | Blood Processing Apparatus with Incipient Spill-Over Detection - A density centrifuge blood processing system comprising a separation chamber rotating about a central rotation axis, the separation chamber being coupled to an elutriation chamber, a first detector for the separation chamber to detect light from an observation region, a computational apparatus distinguishing at least two regions in the observation region and distinguishing incipient spill over of cellular components out of the elutriation chamber as a function of light intensity received from the at least two regions in the separation chamber, and a controller regulating speed of at least one pump or of the separation chamber in response to signals from the computational apparatus to avoid spill over. | 04-01-2010 |
20100065507 | Blood Processing Apparatus with Optical Reference Control - A density centrifuge blood processing system with automatic two-dimensional optical control of fluid separation by observing fluid characteristics in observation regions. The location of the regions is determined by monitoring an optical reference. Points representing edges of an optical reference are measured and lines are computed through the points. An error measurement is calculated for each line. If the error is too large, the image is abandoned. One of the lines is selected as a referent line. A new line is calculated orthogonal to the referent line. The error function is again computed for the dependant line. If the error exceeds a selected maximum, the frame is discarded. A transformation function translates data points from an (r, s) domain derived from measurements of the edges into an (x, y) domain used to identify pixels in the observation areas. | 03-18-2010 |
20100065483 | Blood Processing Apparatus With Cell Capture Chamber with Protruding Inlet - A disposable blood separation set of a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having a protruding inlet therein. The protruding inlet may have a frustro-conical inner surface that slants radially outwardly from an inlet to a mouth of the protruding inlet. A circumferential well may surround the protruding inlet. The cell separation chamber may have a baffle within a separation area. The baffle may have a plurality of vanes with openings therein. | 03-18-2010 |
20100042260 | Predictor of When to Harvest Cells Grown in a Bioreactor - This invention relates to a cell expansion system and to a method of determining when to harvest cells from the cell expansion system. | 02-18-2010 |
20100042038 | System and Method for Collecting Plasma Protein Fractions from Separated Blood Components - Method and apparatus for separating plasma from blood in a membrane separator and further separator the separated plasma into desired plasma proteins in a plasma separator fluidly connected to the membrane separator to receive the separated plasma. | 02-18-2010 |
20100042037 | System and Method for Collecting Plasma Protein Fractions from Separated Blood Components - Method and apparatus for separating plasma from blood in a separation vessel and further separator the separated plasma into desired plasma proteins in a plasma separator fluidly connected to the separation vessel to receive the separated plasma. | 02-18-2010 |
20100026986 | Method and Apparatus for Separating A Composite Liquid Into At Least Two Components And For Determining The Yield Of At Least One Component - Method and Apparatus for predicting the yield of a selected cellular component from a composite blood product by sensing the movement of the separated cellular component or another component during expression from a separation container to a collection container to produce a signal indicative of the movement, and predicting the yield of the separated cellular component from the signal. | 02-04-2010 |
20100025336 | Predictive Method for Controlling a Blood Processing System - The invention relates generally to methods of monitoring and controlling the processing of blood and blood samples, particularly the separation of blood and blood samples into its components. In one aspect, the invention relates to optical methods for measuring two-dimensional distributions of transmitted light intensities, scattered light intensities or both from a separation chamber of a density centrifuge. The method may include performing first and second measurements of an operating condition; analyzing the first and second measurements using a predictive data analysis algorithm; comparing the predicted operating condition to a desired operating condition; and adjusting at least one setting. | 02-04-2010 |
20100012592 | Method for Controlling a Blood Processing System by Observing a Separation Region and an Extraction Port - The invention relates generally to methods of monitoring and controlling the processing of blood and blood samples, particularly the separation of blood and blood samples into its components with a two-dimensional optical measurement and control device. The method may comprise the steps of providing a blood processing system comprising a density centrifuge blood processing system and an elutriation blood processing system; filling the elutriation blood processing system with a desired component; measuring a cellular flux of cells entering the elutriation blood processing system with a two-dimensional optical control system; and flushing the elutriation blood processing system. | 01-21-2010 |
20090317305 | Bag Set for Separating Discrete Volumes of A Composite Liquid - A set of bags having a three-way connector shaped to allow an outlet channel and tube connected thereto to be closer to the rotation axis of a centrifuge than another connected outlet and tube. | 12-24-2009 |
20090272701 | Centrifuge Apparatus and Method for Selectively Reducing Forces on a Biologic Fluid - A centrifuge blood component separation system for separating components of a blood product, comprising a separation vessel; a first transfer bag; a second transfer bag with an outside edge generally congruent to an outside edge of the first transfer bag and further having a central collection area spaced away from the outside edge. The second transfer bag may have additional collection areas. A perforated seam between collection areas allows the second collection bag to be separated into a plurality of bags after collection of blood components. The system has a centrifuge apparatus comprising a rotor having a central compartment for receiving the transfer bags. | 11-05-2009 |
20090166298 | Methods And Apparatus For Controlled Addition Of Solutions To Blood Components - A centrifugal blood processing apparatus comprising a centrifuge rotor, a separation chamber, a tubing set for conducting blood components and fluids and having an inlet line, an outlet line and a storage solution line in fluid communication with the outlet line at a junction. The apparatus controls pumps to conduct a predetermined quantity of storage solution to a collected blood component. The apparatus also purges blood components in the tubing set by applying a negative pressure and positive pressure. A disposable blood processing set has a separation chamber; a tubing set including an inlet line in fluid and an outlet and a storage solution line connected to the outlet line at a junction. | 07-02-2009 |
20090166297 | Blood Processing Apparatus with Controlled Cell Capture Chamber Trigger - A blood cell collection system having means for detecting when a cell separation chamber has filled with white blood cells, and flushing the cells out of the cell separation chamber into a collect bag. A red-green sensor senses the optical characteristics of fluid leaving the cell separation chamber. A baseline value is calculated. The device calculates a ratio of the intensities of red light and green light and a peak-to-peak ratio of intensities. If either ratio exceeds thresholds computed from the baseline, the device flushes the cells into the collect bag. A camera detects white cells passing into the cell separation chamber and the device calculates the number of cells being collected. If the calculated number of collected cells exceeds a certain limit, the cell separation chamber is flushed. If the device is unable to establish a baseline, the donation can proceed, relying solely on the calculated number of collected cells. | 07-02-2009 |
20090156383 | Blood Processing Apparatus With Sealed Diffuser in Optical Control Apparatus - A centrifugal blood separation apparatus having an optical camera control system with a focused, stationary light source. A diffusion plate mounted on a rotor, rather than on or near the light source, allows an intense light beam to be transmitted from the light source to the rotor and then diffused at the rotor across an observation region. Different characteristics of a diffusion surface allow different lighting regions within the observation region. The diffusion plate has upper and lower plates with a diffusion surface sealed between the plates. This prevents degradation or contamination of the diffusion surface by abrasion, dirt, blood components or other materials that might incidentally contact the diffusion surface. | 06-18-2009 |
20090127206 | Blood Component Processing System Method - A method used in connection with processing of blood components, wherein blood products are then filtered via a filter rotating along with a centrifuge rotor and the sensed pressure may be used in connection with controlling the pumping of the blood products and/or in connection with determining the location of an interface associated with the blood products. | 05-21-2009 |
20090105683 | Disposable Injection-Molded Container for Biologic Fluids and Method of Manufacture - A disposable container for biologic materials comprising a sheet of flexible material with an access area integrally molded in the sheet. At least one port in the access area passes fluid into the container. The sheet is folded along the access area such that an upper part is adjacent a lower part, and the upper part is attached to the lower part. The method for making the container includes forming a sheet having an access area integrally molded in the sheet, folding the sheet along the access area, and joining the upper part to the lower part. The upper and lower sheets and the access area are injection-molded as a single, unitary piece. This process uses a mold having a central triangular prism and conforming upper and lower blocks. | 04-23-2009 |
20090043237 | METHODS AND DEVICES FOR PROCESSING BLOOD - Methods, devices and device components are presented for blood processing. Particularly, methods, devices and device components are presented for separating blood into blood components and collecting one or more separated blood components, which reduce the incidence of blood vessel infiltration and enhance donor comfort. In one aspect, the invention provides blood processing methods having a return flow rate which decreases systematically during a return time. In another aspect, the invention provides blood processing methods having a removal flow rate, return flow rate or both which are derived from a subject's total blood volume. In another aspect, the present invention provides blood processing methods wherein the fraction by volume of removed blood corresponding to collected components is selected to optimize blood processing efficiency and enhance the purities of collected blood components. | 02-12-2009 |