CARIDIANBCT BIOTECHNOLOGIES, LLC Patent applications |
Patent application number | Title | Published |
20110306617 | Methods and Compositions for the Production of High Concentration Alloxazine Solutions - Methods are provided for preparation of compositions having an enhanced level of soluble alloxazine, as compared to compositions prepared using conventional techniques. Compositions and a riboflavin form having higher solubility in solution is also provided. | 12-15-2011 |
20110236876 | Induction of and Maintenance of Nucleic Acid Damage in Pathogens Using Riboflavin and Light - A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process comprises adding to the blood or blood component containing pathogens an effective amount of riboflavin, and exposing the fluid to light of an appropriate wavelength to damage the nucleic acid of the pathogen and to substantially maintain the damage to the pathogenic nucleic acids to allow for subsequent transfusion into a recipient. | 09-29-2011 |
20110019182 | Apparatus for Photo Reduction of Contaminants in Blood and Blood Products with Calibration Means - An apparatus for irradiating blood or blood products, preferably with ultra violet or visible light, to reduce contaminants in the blood or blood products. A removable radiometer having light integrating chambers detects the light intensity, allowing the radiation characteristics of the apparatus to be calibrated. A control circuit uses the measurements to control the delivery of an effective dose of illumination to blood or blood products in a bag or container. One or more light integrating optical chambers in the radiometer allow a single light sensor to sense light across an entire field. Thermistors in the irradiating apparatus or the radiometer or both sense the temperature of photo sensors. The control circuit compensates for temperature-dependant variations in the output of the photo sensors. | 01-27-2011 |
20110014239 | Preparation of Vaccines Using Photosensitizer and Light - Methods are provided for treating a vaccine containing infectious particles which may be viral, bacterial, and/or cellular in nature. Preferred methods include the steps of adding an effective, non-toxic amount of an endogenous photosensitizer to the fluid and exposing the fluid to photoradiation sufficient to inactivate the infectious particles but not enough to damage the antigenic characteristics of the infectious particles. | 01-20-2011 |
20100282980 | Stable Calibration Means for Apparatus for Photo Reduction of Contaminants in Blood - An apparatus for irradiating blood or blood products, preferably with ultra violet or visible light, to reduce contaminants in the blood or blood products. A removable radiometer having light integrating chambers detects the light intensity, allowing the radiation characteristics of the apparatus to be calibrated. The light chambers have an aluminum reflecting surface prepared by machining, grit blasting, polishing and plasma treatment including plasma cleaning and oxidation. | 11-11-2010 |
20100189597 | Methods and Systems for Preparing Blood Products - The present invention is related to pre-connected disposable sets including a pre-connected bag containing a photosensitizer for use in a blood separation and pathogen inactivation procedure. | 07-29-2010 |
20100089840 | Removal of Adenine During A Pathogen Reduction Process in Whole Blood or Red Blood Cells by Dilution - The methods of this invention involve preventing the formation of a complex between adenine and riboflavin by reducing the amount of adenine in a solution containing blood or blood components to be pathogen reduced. | 04-15-2010 |
20100080781 | Preventing Transfusion Related Complications in a Recipient of a Blood Transfusion - This invention is directed toward a process for reducing transfusion related complications in a recipient of an allogeneic blood transfusion by adding to the blood to be transfused a photosensitizer comprising riboflavin, irradiating the blood and riboflavin with light, transfusing the irradiated blood into a recipient, and reducing a transfusion related complication by the recipient to cells in the donor blood. | 04-01-2010 |
20090317296 | Clamp Assembly for Displacing Fluid from Portions of Fluid Containers - Clamps and methods are disclosed for clamping portions of fluid containers and displacing fluid from portions of fluid containers. In one embodiment, a clamp has a first jaw having a photopermeable main body portion and a second jaw. The first and second jaws are operatively associated so that at least one jaw, or both jaws, may be moved between clamped and released positions. The clamp is sized to receive a portion of a fluid container and displace fluid in the fluid container from a clamped region of the fluid container when the first and/or second jaw(s) are in the clamped position. The photopermeable main body portion(s) of the first and/or second jaw(s) allow some light to reach the clamped region of the fluid container during photoradiation to inactivate pathogens in the fluid. Various clamp embodiments and assemblies having lock members and interlocks are also disclosed herein. | 12-24-2009 |
20090023130 | Prevention of Transfusion Related Acute Lung Injury Using Riboflavin and Light - This invention is directed toward a method of preventing the formation of bioactive substances in a pathogen inactivated blood component. The steps include illuminating the blood component with light at a sufficient energy so that an alloxazine photosensitizer present in the blood component may be photolyzed to inactivate any pathogens which may be present; preventing the formation of bioactive substances in the pathogen inactivated blood component; and storing the pathogen inactivated blood component. | 01-22-2009 |
20080299538 | Pathogen Inactivation of Whole Blood - This invention is directed toward a method of pathogen inactivating whole blood. The steps include collecting whole blood from a donor into a bag; illuminating the whole blood with light at a sufficient energy so that an alloxazine photosensitizer present in the whole blood may be photolyzed to inactivate any pathogens which may be present in the whole blood; and storing the pathogen inactivated whole blood. The invention also includes a method of separating the pathogen inactivated whole blood into components. | 12-04-2008 |