BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG Patent applications |
Patent application number | Title | Published |
20140286879 | COMBINATIONS OF MEDICAMENTS FOR THE TREATMENT OF RESPIRATORY DISEASES - A pharmaceutical composition comprising: | 09-25-2014 |
20140116435 | INHALER FOR THE ADMINISTRATION OF AN ANTICHOLINERGIC - An inhalation kit comprising: (a) an inhaler displaying a flow resistance of about 0.01 to 0.1, √{square root over (kPa)} min/L; and (b) an inhalable powder comprising tiotropium in admixture with a physiologically acceptable excipient with an average particle size of between 10 to 500 μm, and a method of administering an inhalable powder containing tiotropium in admixture with a physiologically acceptable excipient with an average particle size of between 10 pm to 500 μm, the method comprising actuating an inhaler a flow resistance of about 0.01 to 0.1 √{square root over (kPa)} min/L containing the inhalable powder. | 05-01-2014 |
20140076308 | NOZZLE AND INHALER AND METHOD FOR PRODUCING A NOZZLE - A nozzle, an inhaler with a nozzle and a method for producing a nozzle are proposed. The nozzle comprises two holes formed in a flat plate. Then, the plate is deformed such that the axes of the holes intersect so that jets of fluids generated by the holes impinge with each other. | 03-20-2014 |
20140057901 | XANTHINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS - The present invention relates to substituted xanthines of general formula | 02-27-2014 |
20140056823 | COMBINATIONS OF MEDICAMENTS FOR THE TREATMENT OF RESPIRATORY DISEASES - A pharmaceutical composition comprising:
| 02-27-2014 |
20130317008 | Use of a Specific Cyclic Amine Derivative or the Pharmaceutically Acceptable Salts Thereof for the Treatment or Prevention of Heart Failure - The present invention provides the use in a pharmaceutical composition of a specific cyclic amine derivative, or its pharmaceutically acceptable salts, for the treatment or prevention of heart failure of any aetiology. | 11-28-2013 |
20130309307 | Bilayer Pharmaceutical Tablet Comprising Telmisartan and a Diuretic and Preparation Thereof - The present invention relates to a bilayer pharmaceutical tablet comprising a first layer formulated for immediate release of the angiotensin II receptor antagonist telmisartan from a dissolving tablet matrix which contains telmisartan in substantially amorphous form, and a second layer formulated for immediate release of a diuretic like hydrochlorothiazide from a fast disintegrating tablet matrix. A method of producing the bilayer tablet is also disclosed. | 11-21-2013 |
20130303760 | New Process For The Preparation Of Nitroorotic Acid - Subject of the present invention is a new improved process for the preparation of nitroorotic acid via nitration of orotic acid. | 11-14-2013 |
20130197196 | PROTEIN PRODUCTION - The invention concerns the field of protein production and cell culture technology. CERT is identified as a novel in vivo PKD substrate. Phosphorylation on serine 132 by PKD decreases the affinity of CERT towards its lipid target phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity, identifying PKD as a regulator of lipid homeostasis. The present invention shows that CERT in turn is critical for PKD activation and PKD dependent protein cargo transport to the plasma membrane. The interdependence of PKD and CERT is thus a key to the maintenance of Golgi membrane integrity and secretory transport. | 08-01-2013 |
20130196430 | PROTEIN PRODUCTION - The invention concerns the field of protein production and cell culture technology. CERT is identified as a novel in vivo PKD substrate. Phosphorylation on serine 132 by PKD decreases the affinity of CERT towards its lipid target phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity, identifying PKD as a regulator of lipid homeostasis. The present invention shows that CERT in turn is critical for PKD activation and PKD dependent protein cargo transport to the plasma membrane. The interdependence of PKD and CERT is thus a key to the maintenance of Golgi membrane integrity and secretory transport. | 08-01-2013 |
20130177943 | NOVEL REGULATORY ELEMENTS - The invention concerns novel regulatory elements as well as related vectors and cells. Furthermore, it relates to methods of improving expression of polypeptides from nucleic acids such as cloned genes and to the production of various polypeptides in host cells using said novel regulatory elements. Additionally, the invention relates to uses of said novel regulatory elements as insulators, in gene therapy or for improving host cell lines. | 07-11-2013 |
20130177919 | PROTEIN PRODUCTION - The invention concerns the field of protein production and cell culture technology. CERT is identified as a novel in vivo PKD substrate. Phosphorylation on serine 132 by PKD decreases the affinity of CERT towards its lipid target phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity, identifying PKD as a regulator of lipid homeostasis. The present invention shows that CERT in turn is critical for PKD activation and PKD dependent protein cargo transport to the plasma membrane. The interdependence of PKD and CERT is thus a key to the maintenance of Golgi membrane integrity and secretory transport. | 07-11-2013 |
20130165428 | XANTHINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS - The present invention relates to substituted xanthines of general formula | 06-27-2013 |
20130152924 | NOZZLE AND INHALER AND METHOD FOR PRODUCING A NOZZLE - A nozzle, an inhaler with a nozzle and a method for producing a nozzle are proposed. The nozzle comprises two holes formed in a flat plate. Then, the plate is deformed such that the axes of the holes intersect so that jets of fluids generated by the holes impinge with each other. | 06-20-2013 |
20130140351 | FOLDING BOX - The invention relates to a folding box made from a one-piece cardboard blank ( | 06-06-2013 |
20120329778 | BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR PREPARING THEM - The present invention relates to bicyclic heterocycles of general formula | 12-27-2012 |
20120296091 | POLYMORPHS - The invention relates to polymorphous crystal modifications of a DPP-IV inhibitor, the preparation thereof and the use thereof for preparing a medicament. | 11-22-2012 |
20120285451 | TWO-PIECE METAL CAPSULE FOR ACCOMMODATING PHARMACEUTICAL PREPARATIONS FOR POWDER INHALERS - The invention relates to novel two-piece metal capsules for accommodating pharmaceutical preparations to be used in powder inhalers as well as a method for producing said capsule. The inventive capsules are particularly impermeable to steam and oxygen. | 11-15-2012 |
20120263787 | METHOD AND APPARATUS FOR SEALING MEDICINAL CAPSULES - A method of sealing parts of a plastic capsule by forming a weld seam in an overlapping region of the parts of the capsule, wherein the capsule comprises a capsule cap having an open end and a capsule body having an open end, and capsules formed by such method. The capsules produced by the process according to the invention are disposable and preferably contain a single dose of a pharmaceutical formulation in the form of a powder or liquid intended to be administered by inhalation and are suitable by their form and function for use in powder inhalers or liquid nebulizers for producing aerosols. Aerosols thus produced can be inhaled, for example, in order to administer a pharmaceutical formulation to the lungs. | 10-18-2012 |
20120211007 | INHALER FOR THE ADMINISTRATION OF AN ANTICHOLINERGIC - An inhalation kit comprising: (a) an inhaler displaying a flow resistance of about 0.01 to 0.1, √{square root over (kPa)} min/L; and (b) an inhalable powder comprising tiotropium in admixture with a physiologically acceptable excipient with an average particle size of between 10 to 500 μm, and a method of administering an inhalable powder containing tiotropium in admixture with a physiologically acceptable excipient with an average particle size of between | 08-23-2012 |
20120208831 | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions - The present invention relates to substituted xanthines of general formula | 08-16-2012 |
20120189556 | PHARMACEUTICAL COMPOSITIONS BASED ON ANTICHOLINERGICS AND CORTICOSTEROIDS - A pharmaceutical composition comprising an anticholinergic and a steroid, optionally together with a pharmaceutically acceptable excipient, the anticholinergic and the steroid optionally in the form of their enantiomers, mixtures of their enantiomers, their racemates, their solvates, or their hydrates, processes for preparing them, and their use in the treatment of respiratory tract diseases. | 07-26-2012 |
20120031802 | METHOD AND APPARATUS FOR SEALING MEDICINAL CAPSULES - A method of sealing parts of a plastic capsule by forming a weld seam in an overlapping region of the parts of the capsule, wherein the capsule comprises a capsule cap having an open end and a capsule body having an open end, and capsules formed by such method. The capsules produced by the process according to the invention are disposable and preferably contain a single dose of a pharmaceutical formulation in the form of a powder or liquid intended to be administered by inhalation and are suitable by their form and function for use in powder inhalers or liquid nebulizers for producing aerosols. Aerosols thus produced can be inhaled, for example, in order to administer a pharmaceutical formulation to the lungs. | 02-09-2012 |
20110312029 | NOVEL REGULATORY ELEMENTS - The invention concerns novel regulatory elements as well as related vectors and cells. Furthermore, it relates to methods of improving expression of polypeptides from nucleic acids such as cloned genes and to the production of various polypeptides in host cells using said novel regulatory elements. Additionally, the invention relates to uses of said novel regulatory elements as insulators, in gene therapy or for improving host cell lines. | 12-22-2011 |
20110303740 | FOLDING BOX - The invention relates to a folding box made from a one-piece cardboard blank ( | 12-15-2011 |
20110281301 | THE SECRETORY CAPACITY IN HOST CELLS - The invention concerns the field of protein production and cell culture technology. It describes a method of producing a heterologous protein of interest in a cell comprising a. Increasing the expression or activity of a secretion enhancing gene, and b. Increasing the expression or activity of an anti-apoptotic gene, and c. Effecting the expression of said protein of interest, whereby the secretion enhancing gene is a gene encoding a protein whose expression or activity is induced during one of the following cellular processes: plasma-cell differentiation, unfolded protein response (UPR), endoplasmic reticulum overload response (EOR). | 11-17-2011 |
20110262967 | USE OF HSA-PRODUCING CELLS - The present invention refers to the area of cell culture technology and relates to methods for multiplying/cloning cells, preferably cell lines, which are important to the production of biopharmaceuticals. The invention further relates to methods for manufacturing proteins and to the use of cells extracted and multiplied through single cell sorting and to media compositions that enable a multiplication of single cells. Through the use of albumin-producing, preferably HSA-producing, cells as feeder cells for the conditioning of medium or as host cells, the recloning efficiency and thereby the quantity of clones obtained can be significantly increased. A combination of these approaches is also possible. Through the use of albumin-producing, preferably HSA-producing, cells, an increase in the recloning efficiency can be achieved in serum-free and/or insulin-free medium as well, and in different cell types. | 10-27-2011 |
20110250640 | METHOD OF RECLONING PRODUCTION CELLS - A new method for selecting clones and recloning mammalian cells which are of importance for the production of biopharmaceuticals, preferably hamster or mouse myeloma cells, with a high degree of automation and throughput. The invention relates to methods of depositing and replicating single cell clones of the cells in question. The invention also relates to methods of preparing proteins using cells which have been obtained and replicated by single cell deposition as well as compositions which allow the replication of single cells. | 10-13-2011 |
20110230642 | METHOD FOR INCREASING RECLONING EFFICIENCY - The present invention relates to the field of cell culture technology and relates to methods of replicating/cloning cells, preferably cell lines which are important for the production of biopharmaceuticals. The invention also relates to methods of preparing proteins using cells that have been obtained and replicated by single cell deposition and compositions which make it possible to replicate individual cells. | 09-22-2011 |
20110189729 | NOVEL RECOMBINATION SEQUENCES - The present invention relates to novel nucleotide sequences, which are variants of att recombination sequences, involved in sequence-specific recombination of DNA in eukaryotic cells, whereby sequence specific recombination is performed by a bacteriophage lambda integrase Int. Such novel att recombination sequences being e.g. attP.b, attP.a, attL.a, attR.a and attR.b. The present invention further relates to a method of sequence-specific recombination of DNA in eukaryotic cells, comprising the introduction of a first DNA comprising a nucleotide sequence containing at least one recombination sequence into a cell, introducing a second DNA comprising a nucleotide sequence containing at least one further recombination sequence into a cell, and performing the sequence specific recombination by a bacteriophage lambda integrase Int, whereby at least one of said first or second DNAs is a novel att recombination sequences being e.g. attP.b, attP.a, attL.a, attR.a and attR.b. | 08-04-2011 |
20110186044 | DOSAGE AEROSOLS FOR THE APPLICATION OF PHARMACEUTICAL FORMULATIONS - The invention relates to pharmaceutical active substances, active substance mixtures and formulations for use as an aerosol in propellant-containing [1.1.1.2-tetrafluoroethane (HFC-134a) or 1.1.1.2.3.3.3-heptafluoropropane(HFC-227)] metered-dose aerosols and the metered-dose aerosols for administering these active substances, active substance mixtures and formulations. | 08-04-2011 |
20110168175 | CARTRIDGE SYSTEM - An inhaler including a pre-inserted cartridge ( | 07-14-2011 |
20110120465 | Inhaler and sieve for an inhaler - The invention relates to an inhaler ( | 05-26-2011 |
20110046168 | METHODS OF TREATING DISEASES USING QUINAZOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - A compound of general formula I | 02-24-2011 |
20110041844 | NOZZLE AND INHALER AND METHOD FOR PRODUCING A NOZZLE | 02-24-2011 |
20110005517 | ATOMIZER, AND FILTER - Disclosed are an atomizer for a fluid, especially for medical aerosol therapy, and a filter for said atomizer in order to prevent germs from spreading. The atomizer comprises a protective device for preventing germs from infesting the preferably preservative-free fluid. Particularly the filter can be used as a protective device. This prevents germs from infesting the fluid during the service life of the atomizer even when the atomizer is used several times. | 01-13-2011 |
20100331544 | METHOD FOR PRODUCING (1R,5S) ANHYDROECGONINE ESTER SALTS - The invention relates to a large-scale method for producing salts of (IR,5S) anhydroecgonine esters. The salt formation and selective crystallization of (IR,5S) anhydroecgonine esters with chiral acids is highly efficient in producing an enantiomer form, any undesired enantiomers and other impurities being removed. The ester and its salts are used as the starting material for producing active agents. | 12-30-2010 |
20100326438 | DRY POWDER INHALER - An inhaler is proposed which comprises a chamber containing powder. The powder can be discharged by an airflow. The airflow through the chamber is regulated by means of a valve at a desired or required minimum flow rate. The flow rate through the chamber is kept essentially constant. | 12-30-2010 |
20100324288 | Dihydropteridinone Compounds - Disclosed are new dihydropteridinones of general formula (I) | 12-23-2010 |
20100310477 | Pharmaceutical compositions based on anticholingerics and additional active ingredients - A pharmaceutical composition comprising an anticholinergic and at least one additional active ingredient selected from among corticosteroids, dopamine agonistes, PDE-IV inhibitors, NK1-antagonists, endothelin antagonists, antihistamines, and EGFR-kinase inhibitors, processes for preparing them and their use in the treatment of respiratory diseases. | 12-09-2010 |
20100305146 | Method for the Production of 1,3-Dioxolane-2-Ones and Carboxylic Acid Esters by Means of Transacylation in Basic Reaction Conditions - The invention relates to a method for producing 1,3-dioxolane-2-ones of general formula (3) in basic reaction conditions by reesterifying the respective ester of general formula (1) in which R1 to R5 have the meanings indicated in the claims and the description. The invention further relates to a method for producing 2-hydroxy carboxylic acid esters of general formula (5) with or without isolation of the intermediate in the form of a derivative of the 1,3-dioxolane-2-one of general formula (3) in basic reaction conditions by reesterifying the respective ester of general formula (1) in which R1, R2, and R6 have the meanings indicated in the claims and the description. The method according to the invention allows the reaction to take place in very gentle basic conditions, causing fewer secondary reactions and providing a greater yield than reactions in highly polar aprotic solvents. Acid-sensitive and/or temperature-sensitive compounds can be synthesized. | 12-02-2010 |
20100297697 | METHODS FOR INCREASING PROTEIN TITERS - The invention relates to methods of increasing the titre of a protein of interest in a cell as well as the improved production and purification of optimised biomolecules, one component of which is the domain C | 11-25-2010 |
20100267960 | PROCESS FOR PREPARING PRAMIPEXOLE DIHYDROCHLORIDE TABLETS - The present invention relates to a process for preparing tablets of pramipexole dihydrochloride. In particular, the present invention relates to a process for preparing tablets of pramipexole dihydrochloride wherein the tablets exhibit enhanced storage stability properties. | 10-21-2010 |
20100220187 | OPTICAL MEASUREMENT OF FILL LEVEL - The invention relates to the optical measurement of fill level in the aseptic bottling or packaging of biopharmaceuticals. The process according to the invention allows in particular in-process fill level measurement of primary packaging means filled with protein solution with small volumes and with considerable variations in the packaging means. The invention also relates to an apparatus according to FIG. | 09-02-2010 |
20100215590 | Micronization Method - The invention relates to a method for producing a micronized, virtually anhydrous form of (1α,2β,4β,5α,7β)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0 | 08-26-2010 |
20100152171 | CGRP Antagonists - CGRP antagonists of the formula | 06-17-2010 |
20100152167 | PYRIMIDINE DERIVATIVES - The present invention relates to trisubstituted pyrimidines of formula (I) | 06-17-2010 |
20100144703 | XANTHINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS - Disclosed are substituted xanthines of general formula | 06-10-2010 |
20100144639 | USE OF INHIBITORS OF THE EGFR-MEDIATED SIGNAL TRANSDUCTION FOR THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA (BPH) / PROSTATIC HYPERTROPHY - The present invention relates to the use of specific EGF-receptor antagonists for preparing a pharmaceutical composition for the prevention and/or treatment of benign prostatic hyperplasia and/or prostatic hypertrophy, a method for the treatment or prevention of benign prostatic hyperplasia/prostatic hypertrophy comprising administering an EGF-receptor antagonist of groups (A), (B) or (C), described herein optionally in combination with known compounds for the treatment of benign prostatic hyperplasia/prostatic hypertrophy, as well as associated pharmaceutical compositions. | 06-10-2010 |
20100143331 | METHOD FOR MIXING POWDERS - The invention relates to a method for preparing powder mixtures, one component consisting of spray-dried powder. The invention also relates to a method for coating spray-dried particles with nanoscale particles, a method for mixing spray-dried powder with microscale particles and a method for covering carrier substances with spray-dried particles. | 06-10-2010 |
20100137550 | Method and Device for Cleaning an Absorptive Polyester - In a method for cleaning an absorptive polyester, the polymer is dissolved in a first solvent ( | 06-03-2010 |
20100125434 | Computer-implemented methods for evaluating, summarizing and presenting data on stability of drug substances and drug products and software-modified computers for such methods - Computer-implemented methods for statistical analysis and summarization of a stability study on a pharmaceutical product using of a macro integrated into statistical analysis software. The method includes inputting and summarizing data observed for a stability study on a pharmaceutical product, statistically analyzing the data, including using at least one regression function to characterize the time-response relationship of at least one stability response variable, to estimate a shelf life of the pharmaceutical product or confirm the shelf life of an existing pharmaceutical product, and providing standardized output data and graphical presentations of observed stability response data. Also, a computer loaded with a general statistical analysis software and a macro integrated with the software such that the computer is capable of performing these computer-implemented methods using the software and macro. | 05-20-2010 |
20100113411 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions - The present invention relates to CGRP antagonists of general formula | 05-06-2010 |
20100105898 | METHOD FOR PRODUCING SCOPINIUM SALTS - The invention relates to a new method of preparing scopinium salts of general formula 1 | 04-29-2010 |
20100096408 | Apparatus For The Dispensing Of Liquids, Container Cartridge Suitable For This, And System Comprising The Apparatus For The Dispensing Of Liquids And The Container Cartridge - The present invention relates to a propellant-gas-free apparatus for the dispensing of liquids, a container cartridge suitable for this for storing the liquid and the ensemble comprising both. The invention comprises a device for the exertion of pressure and for accommodating a container cartridge and a container cartridge in which the dispensing facility is integrated. | 04-22-2010 |
20100086967 | CELL GROWTH - The invention concerns the field of cell culture technology. It concerns a method of improving cell growth, especially the growth of biopharmaceutical producer host cells. The invention further concerns a method of producing proteins using the cells generated by the described method. | 04-08-2010 |
20100086947 | USE OF FLOW-CYTROMETRIC ANALYSIS TO OPTIMIZE CELL BANKING STRATEGIES FOR CHO CELLS - Production of biopharmaceuticals from CHO cells requires generation of master-, working- and post-production cell banks of high quality, partly under GMP conditions. An optimal cryopreservation strategy is needed for each new production cell line, particularly with regard to the desire to establish production processes that are completely devoid of serum or even any animal components and to ensure robust thaw performance for reliable production. Here we describe a novel strategy employing flow cytometric (FC) analysis of Annexin V-stained cells for high-throughput characterization of CHO cell banks. Our data show that this method enables evaluation of a cryopreservation procedure just 6 h after thaw. | 04-08-2010 |
20100069414 | BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR PREPARING THEM - The present invention relates to bicyclic heterocycles of general formula | 03-18-2010 |
20100021911 | PRODUCTION HOST CELL LINES - The invention concerns the field of cell culture technology. The invention describes production host cell lines comprising vector constructs comprising a DHFR expression cassette. Those cell lines have improved growth characteristics in comparison to DHFR-deficient or DHFR-reduced cell lines such as CHO DG44 and CHO DUKX-B11. The invention especially concerns two cell lines, a representative of each cell line is deposited with the DSMZ under the number DSM ACC2909 (CHOpper® Discovery) and DSM ACC2910 (CHOpper® Standard). The invention further concerns a method of producing proteins using the cells generated by the described method. | 01-28-2010 |
20100010023 | QUINAZOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - A compound of general formula I | 01-14-2010 |
20090326633 | CONTROLLED RELEASE ENDOPROSTHETIC DEVICE - The invention relates to improved drug-delivery endoprosthetic device for insertion at a vascular site via catheter placement at the site, comprising:
| 12-31-2009 |
20090306104 | Use of Lck inhibitors for treatment of immunologic diseases - The invention relates to a method of treating immunologic diseases or pathological conditions involving an immunologic component using certain Lck inhibitors already known as kinase inhibitors for therapy in oncology, optionally in combination with one or more other drugs selected from NSAIDs, steroids, DMARDs, immunsuppressives, biologic response modifiers and antinfectives, pharmaceutical compositions comprising said Lck inhibitors together with said other drugs, and the use of the Lck inhibitors for the manufacture of a pharmaceutical composition for the treatment of immunologic diseases or pathological conditions involving an immunologic component. | 12-10-2009 |
20090306072 | USE OF TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY PROCESSES - A method of treating inflammatory diseases of the airways or intestines which comprises administering substances selected from the group consisting of:
| 12-10-2009 |
20090253904 | Process for the Preparation of a Tetrahydro-1H-Azepines - The invention relates to an improved process for the preparation of a tetrahydro-1H-azepine of formula I | 10-08-2009 |
20090203683 | BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, THEIR USE, AND PROCESSES FOR PREPARING THEM - A compound of formula (I) | 08-13-2009 |
20090197876 | INDOLINONE DERIVATIVES SUBSTITUTED IN THE 6 POSITION, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS - The present invention relates to indolinone derivatives, substituted in the 6-position, of the formula | 08-06-2009 |
20090148515 | TWO-PIECE METAL CAPSULE FOR ACCOMMODATING PHARMACEUTICAL PREPARATIONS FOR POWDER INHALERS - The invention relates to novel two-piece metal capsules for accommodating pharmaceutical preparations to be used in powder inhalers as well as a method for producing said capsule. The inventive capsules are particularly impermeable to steam and oxygen. | 06-11-2009 |
20090131432 | XANTHINE DERIVATES, THEIR PREPARATION AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS - Compounds of formula (I) | 05-21-2009 |
20090093457 | XANTHINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS - Disclosed are substituted xanthines of general formula | 04-09-2009 |
20090092558 | MEDICAMENTS FOR THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE - A pharmaceutical composition comprising a compound of formula 1 | 04-09-2009 |
20090087405 | Use of Lck inhibitors for treatment of immunologic diseases - The invention relates to a method of treating immunologic diseases or pathological conditions involving an immunologic component using certain Lck inhibitors already known as kinase inhibitors for therapy in oncology, optionally in combination with one or more other drugs selected from NSAIDs, steroids, DMARDs, immunsuppressives, biologic response modifiers and antinfectives, pharmaceutical compositions comprising said Lck inhibitors together with said other drugs, and the use of the Lck inhibitors for the manufacture of a pharmaceutical composition for the treatment of immunologic diseases or pathological conditions involving an immunologic component. | 04-02-2009 |
20090069282 | ALKYNE COMPOUNDS WITH MCH ANTAGONISTIC ACTIVITY AND MEDICAMENTS COMPRISING THESE COMPOUNDS - The present invention relates to alkyne compounds of general formula I | 03-12-2009 |
20090068275 | Process for the Manufacture of Powders of Inhalable Medicaments - The invention relates to an improved process for the production of powders of an inhalable medicament by crystallization from a supersaturated fluid containing said medicament, the method comprising passing along a tubular reactor
| 03-12-2009 |
20090022686 | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF SYSTEMIC INFLAMMATORY RESPONSE SYNDROME - The present invention relates to the use of certain benzimidazoles for preparing a pharmaceutical composition for the treatment of systemic inflammatory response syndrome and particularly sepsis. | 01-22-2009 |
20080312210 | USE OF A SPECIFIC CYCLIC AMINE DERIVATIVE OR THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF FOR THE TREATMENT OR PREVENTION OF HEART FAILURE - The present invention provides the use in a pharmaceutical composition of a specific cyclic amine derivative, or its pharmaceutically acceptable salts, for the treatment of heart failure of any aetiology. | 12-18-2008 |
20080308103 | Inhalator Capsules - The subject matter of the invention is a capsule, in particular for the packaging of inhalation formulations, in which at least one cavity is enclosed by a wall, characterized in that at least one portion of the wall has a polymer composition that contains at least one adsorbent, as well as said capsule's preferred use. Furthermore an inhaler and secondary packaging containing at least one such capsule are also described. | 12-18-2008 |
20080286259 | USE OF ACTIVATED COAGULATION FACTOR VII FOR TREATING THROMBOLYTIC THERAPY-INDUCED MAJOR BLEEDINGS - Major bleedings induced by thrombolytic/fibrinolytic therapy, including intracranial haemorrhages, are treated by administering to a subject suffering from such bleedings an effective amount of activated coagulation factor VII (VIIa) or a functional derivative thereof. | 11-20-2008 |
20080199375 | Installation and Device for Guiding a Gas for Devices Used to Treat Granular Products by Drying, Film Coating and Coating - The invention relates to an installation ( | 08-21-2008 |