| Board of Regents, The University of Texas System Patent applications |
| Patent application number | Title | Published |
|---|
| 20160138596 | AXIAL-FLOW PUMPS AND RELATED METHODS - Miniature (mesoscale) axial-flow pumps including an inlet guide, a stator spaced apart from the inlet guide, and a rotor rotatably disposed between the inlet guide and the stator. | 05-19-2016 |
| 20160138133 | Extraction and Recovery of Yttrium and Rare Earth Elements - Methods for extraction and recovery of rare earth elements are disclosed. In one aspect, heap leaching with a leach solution comprising sulfuric acid is used to extract rare earth elements including yttrium and light and heavy rare earth elements. | 05-19-2016 |
| 20160137776 | Fluorescent Polymers and Applications Thereof - In one aspect, block copolymers are described herein. A block copolymer described herein, in some embodiments, comprises a first block comprising a polymer or oligomer formed from the reaction product of (i) a polycarboxylic acid or a polycarboxylic acid equivalent, (ii) a polyol, and (iii) an amino acid; and a second block comprising a polymer or oligomer that differs from the polymer or oligomer of the first block. In some cases, the polycarboxylic acid or polycarboxylic acid equivalent comprises citric acid, a citrate, or an ester of citric acid. The polyol can comprise an α,ω-n-alkane diol, poly(ethylene glycol), or poly(propylene glycol). In some embodiments, the amino acid forms a pendant group of the polymer or oligomer of the first block and/or forms a luminescent 6-membered ring with the polycarboxylic acid or polycarboxylic acid equivalent. The second block of a block copolymer described herein, in some embodiments, comprises a polylactone. | 05-19-2016 |
| 20160122825 | EFFICIENT FUNCTIONAL GENOMICS PLATFORM - Methods for identifying oncogenic biomarkers specific to a patient's cancer. Methods are also provided for identifying candidate therapeutic agents for treating a patient's cancer based on the oncogenic biomarkers. Methods for treating patient's having cancers that express mutant PIK3R1 and ras genes are also disclosed. | 05-05-2016 |
| 20160122649 | MODIFICATION OF RHEOLOGICAL PROPERTIES OF THERMOTROPIC LIQUID CRYSTALLINE POLYMERS FOR MANUFACTURING FILM PRODUCTS - In some embodiments, a compound and/or method of making a compound includes the modification of rheological properties of thermotropic main chain liquid crystalline polymers (LCPs) by melt state reactive processing. The modified liquid crystalline polymer may have an increased viscosity while retaining its liquid crystal properties. | 05-05-2016 |
| 20160117599 | User-Powered Recommendation System - Recommendation systems are widely used in Internet applications. In current recommendation systems, users only play a passive role and have limited control over the recommendation generation process. As a result, there is often considerable mismatch between the recommendations made by these systems and the actual user interests, which are fine-grained and constantly evolving. With a user-powered distributed recommendation architecture, individual users can flexibly define fine-grained communities of interest in a declarative fashion and obtain recommendations accurately tailored to their interests by aggregating opinions of users in such communities. By combining a progressive sampling technique with data perturbation methods, the recommendation system is both scalable and privacy-preserving. | 04-28-2016 |
| 20160113906 | METHODS OF PREPARING EXTRUDATES - Compositions and methods of preparing amorphous drug formulations through hot melt extrusion which result in decreased decomposition of the desired drug are provided herein. Also provided are methods and compositions which further comprise a pharmaceutically acceptable thermoplastic polymer. In some embodiments, these compositions comprise a therapeutically active agent which is only sparingly soluble in water. | 04-28-2016 |
| 20160111707 | FABRICATION OF BISCROLLED FIBER USING CARBON NANOTUBE SHEET - Fabrication of yarns or other shaped articles from materials in powder form (or nanoparticles or nanofibers) using carbon nanotube/nanofiber sheet as a platform (template). This includes methods for fabricating biscrolled yarns using carbon nanotube/nanofiber sheets and biscrolled fibers fabricated thereby. | 04-21-2016 |
| 20160103227 | LARGE-VOLUME SCINTILLATOR DETECTOR FOR RAPID REAL-TIME 3-D DOSE IMAGING OF ADVANCED RADIATION THERAPY MODALITIES - An apparatus and method for measuring three-dimensional radiation dose distributions with high spatial and temporal resolution using a large-volume scintillator. The scintillator converts the radiation dose distribution into a visible light distribution. The visible light is transported to one or more photo-detectors, which measure the light intensity. The light signals are processed to correct for optical artifacts, and the three-dimensional light distribution is reconstructed. The reconstructed light distribution is post-processed to convert light amplitudes to measured radiation doses. The high temporal resolution of the detector makes it possible to observe the evolution of a dynamic dose distribution as it changes over time. Integral dose distributions can be measured by summing the dose over time. | 04-14-2016 |
| 20160101308 | Drug Disposal System - The present invention comprises a safe and effective system for removal of a range of common pharmaceutical compounds. The formulation comprises activated carbon, accompanied by some larger pebble-like material to help break up capsules and tablets upon shaking, in the presence of an acidified liquid medium. Drugs are added to the bottle and the bottle is shaken so that the drugs are dissolved by the liquid solution and are irreversibly adsorbed onto activated carbon, thereby sequestering them from further use. | 04-14-2016 |
| 20160096902 | CHIMERIC ANTIGEN RECEPTOR-TARGETING MONOCLONAL ANTIBODIES - Provided are monoclonal antibodies that detect CD 19 CAR-modified immune cells and CAR-modified immune cells irrespective of the tumor associated antigen they target. Methods of using these functional monoclonal antibodies include, but are not limited to, detection, quantification, activation, and selective propagation of CAR-modified immune cells. | 04-07-2016 |
| 20160087342 | CIRCUIT-LOADED CONFORMAL METASURFACE CLOAK - An electromagnetic invisibility cloaking device with a broadened cloaking bandwidth and/or a tunable frequency of operation. The cloaking device includes an object (e.g., antenna) and a metasurface ( | 03-24-2016 |
| 20160083872 | FABRICATION OF NANOFIBER RIBBONS AND SHEETS - Fabricating a nanofiber ribbon or sheet with a process that includes providing a primary assembly by arranging carbon nanotube nanofibers in aligned arrays, the arrays having a degree of inter-fiber connectivity, drawing the carbon nanotube nanofibers from the primary assembly into a sheet or ribbon, and depositing the sheet or ribbon on a substrate. | 03-24-2016 |
| 20160074560 | ANTIMICROBIAL CATHETERS - Antimicrobial catheters and medical devices are provided. In some aspects, a low durometer aliphatic polyether polyurethane may be impregnated with a first antimicrobial agent (e.g., minocycline and rifampin) and coated with a second antimicrobial agent (e.g., chlorhexidine, gendine, or gardine). The antimicrobial catheters may display improved flexibility and resistance to kinking. Methods of producing the antimicrobial catheters are also provided. | 03-17-2016 |
| 20160074559 | ANTIMICROBIAL WRAPS FOR MEDICAL IMPLANTS - Biodegradable antimicrobial films are provided that are solid at room temperature and substantially liquefy in situ after implantation into a mammal, such as a human patient. Methods of using the films to cover a medical device, such as a breast implant, prior to insertion into a subject are also provided. | 03-17-2016 |
| 20160069902 | MEASURING CIRCULATING THERAPEUTIC ANTIBODY, ANTIGEN AND ANTIGEN/ANTIBODY COMPLEXES USING ELISA ASSAYS - The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone at least one course of immunotherapy. Yet further, levels of therapeutic antibody:antigen complexes, soluble antigens or soluble therapeutic antibodies may be measured and used to stage or monitor a hyperproliferative disease. | 03-10-2016 |
| 20160068604 | ANTI-OX40 ANTIBODIES AND METHODS OF USING THE SAME - Human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human OX40 are disclosed. Preferred antibodies have high affinity for OX40 receptor and activate the receptor in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, are useful for modulating receptor activity, e.g., in a human subject suffering from a disorder in which OX40 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies are provided, and methods of synthesizing the recombinant human antibodies, are also provided. | 03-10-2016 |
| 20160060260 | BROMODOMAIN INHIBITORS FOR TREATING DISEASE - Disclosed herein are compounds and compositions useful in the treatment of bromodomain-containing protein-mediated diseases, such as cancer, having the structure of Formula I: | 03-03-2016 |
| 20160058759 | GLUTAMINASE INHIBITOR THERAPY - Disclosed herein are methods of treating a subject having an altered NRF2/KEAP1 pathway, and compounds and compositions useful in such treatment. Also disclosed herein are methods of evaluating whether to administer a compound that inhibits glutathione production or a glutaminase inhibitor to a subject. | 03-03-2016 |
| 20160040514 | Reservoir Characterization and Hydraulic Fracture Evaluation - A multi-physics and multi-scale system and process to simulate imaging of hydrocarbon reservoirs using electromagnetic particles and electromagnetic tomography. Embodiments are applicable towards flood-front mapping and hydraulic fracture imaging. With respect to flood-front mapping, coated nanoparticles (or their software representation) may be injected. In case of fracture imaging, the contrast agents (or their software representation) may either be injected as proppants, fibers, or nanoparticles suspended in the solution. | 02-11-2016 |
| 20160038311 | LAYERING TECHNIQUE FOR AN ADJUSTABLE, REPAIRABLE VARIABLE STIFFNESS PROSTHETIC FOOT - A modular prosthetic foot includes a keel section and in some cases, an optional heel section. The keel section may also include an optional toe section. The keel section can include separate layers of various stiffnesses, wherein the optional toe section and the optional heel section are composed of varying stiffness layers nested together. The stiffness of the keel section is adjustable by a user without specialized tools. The components of the prosthetic foot are modular and can be removed and exchanged without altering the fit and alignment of the prosthetic foot. | 02-11-2016 |
| 20160036132 | ANISOTROPIC METAMATERIALS FOR ELECTROMAGNETIC COMPATIBILITY - Embodiments of the invention are directed to a device having one or more electromagnetic components embedded in an anisotropic metamaterial (AM) comprising an array of asymmetric unit cells comprising a substrate forming a plurality of channels or spaces having at least one material with different electromagnetic properties included in the channels or spaces in the first material forming an anisotropic metamaterial. | 02-04-2016 |
| 20160034441 | SYSTEMS, APPARATUSES AND METHODS FOR GENERATING A USER INTERFACE - Systems, apparatuses and methods for generating a graphical user interface (GUI) conforming to a graphical representation employ computer vision, optical character recognition, and other techniques to generate a structure of the GUI as a view hierarchy. A development project with source code and resource files is created to generate an application having the GUI. The application and GUI are applicable to mobile and other platforms using various operating systems, such as Android, iOS, and others. | 02-04-2016 |
| 20160025728 | BRAIN-SPECIFIC GENE SIGNATURE OF TUMOR CELLS - The present disclosure provides a method of detecting and diagnosing metastatic spread of cancer to the brain by analyzing the product of a gene signature. Gene signatures detailed herein are specific to the brain metastasis and not dependent upon the genetic signature of the primary tumor. Accordingly, disclosed method can be used to guide therapeutic intervention and further diagnostic analysis. | 01-28-2016 |
| 20160024503 | miRNA BIOGENESIS IN EXOSOMES FOR DIAGNOSIS AND THERAPY - Methods for diagnosis and treatment of cancers by use of exosomes comprising miRNAs and precursors thereof. For example, in some aspects, a cancer may be diagnosed or evaluated by determining the miRNA content of exosomes in a sample from a subject or by detecting miRNA processing in exosomes. | 01-28-2016 |
| 20160022728 | miRNA FOR TREATING CANCER AND FOR USE WITH ADOPTIVE IMMUNOTHERAPIES - In some aspects, miRNA for the treatment of cancer are provided. In some embodiments, a miRNA (e.g., miR-124, miR-142, and/or miR-138) may be used to promote or enhance immune destruction of a cancer, or reduce the immune suppression of the cancer, in a subject. In other aspects, the miRNA may be used in, or in combination with, an adoptive immunotherapy. | 01-28-2016 |
| 20160002523 | DETERMINATION OF OIL SATURATION IN RESERVOIR ROCK USING PARAMAGNETIC NANOPARTICLES AND MAGNETIC FIELD - Methods for detection of the presence and distribution of oil in subsurface formation are described herein. The present invention involves injection of an aqueous dispersion of the nanoparticles into the potentially oil containing subsurface formation, followed by a remote detection of the oscillation responses of the nanoparticles in the oil/water interfaces in the reservoir rock by applying magnetic field. | 01-07-2016 |
| 20160002248 | GLS1 INHIBITORS FOR TREATING DISEASE - Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: | 01-07-2016 |
| 20160002204 | GLS1 INHIBITORS FOR TREATING DISEASE - Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: | 01-07-2016 |
| 20150374887 | DEVICES AND METHODS FOR THE PREVENTION AND TREATMENT OF NEUROMAS - In one aspect, nerve growth inhibition devices are described herein. In some embodiments, a nerve growth inhibition device described herein comprises a tube having a proximal end and a distal end. A matrix material is disposed in the tube, and the matrix material comprises one or more microchannels. The proximal end of the tube comprises an opening operable to receive nerve tissue, the distal end of the tube is sealed, and the microchannels of the matrix material extend from the proximal end of the tube toward the distal end of the tube. | 12-31-2015 |
| 20150361031 | STAT3 INHIBITOR - Provided are STAT3 inhibitors and methods of treating inflammation or a hyperproliferative disease such as, e.g., cancer. In some aspects, compounds may be used to treat breast cancer, a head/neck cancer, a lung cancer, a prostate cancer, or pancreatic cancer. | 12-17-2015 |
| 20150359945 | ANTIMICROBIAL COATINGS - Provided are polymer-based surfaces (e.g., gloves) with an antimicrobial coating, e.g., comprising chlorhexidine and a partially hydrolyzed polyvinyl acetate copolymer, or a biguanide and a silicone. Methods of coating polymer-based surfaces with antimicrobial compositions are also provided. | 12-17-2015 |
| 20150359840 | Autophagy-Inducing Peptide Analogs - An autophagy-inducing compound comprises an autophagy-inducing peptide comprising Beclin 1 peptides immediately N- and C-terminally flanked by moieties R | 12-17-2015 |
| 20150353936 | ANTIGENE OLIGOMERS INHIBIT TRANSCRIPTION - Transcription of a gene in a mammalian cell is methylase-independently inhibited by contacting the cell with a nucleic acid oligomer of 12-28 bases complementary to a partially single-stranded target genomic sequence of the gene. | 12-10-2015 |
| 20150343056 | PHARMACEUTICAL TARGETING OF A MAMMALIAN CYCLIC DI-NUCLEOTIDE SIGNALING PATHWAY - Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2′3-cGAMP, 2′2-cGAMP, 3′2′-cGAMP and 3′3′-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies and diagnostics. | 12-03-2015 |
| 20150316631 | METHODS AND APPARATUS FOR PHASE CORRECTION IN MAGNETIC RESONANCE IMAGING - Methods, apparatuses, systems, and software for extended phase correction in phase sensitive magnetic resonance imaging utilizing an optimized region-growing based phase correction algorithm. Phase correction is formulated as selecting a vector for each pixel of an image from two input candidate vectors so that the orientation of the output vector is spatially smooth. In certain embodiments, the optimized region growing algorithm uses automated quality guidance for determining the sequence of region growing and jointly considers the two input candidate vectors during region growing. Further, the algorithm tracks the quality and the mode at each step of the processing. Spatially isolated tissue regions are automatically segmented and processed with different threads of region growing and the correct vector is reliably identified as the output vector for each thread of region growing. Final phase correction was performed by pixel level optimization. | 11-05-2015 |
| 20150315726 | FABRICATION OF BISCROLLED FIBER USING CARBON NANOTUBE SHEET - Fabrication of yarns or other shaped articles from materials in powder form (or nanoparticles or nanofibers) using carbon nanotube/nanofiber sheet as a platform (template). This includes methods for fabricating biscrolled yarns using carbon nanotube/nanofiber sheets and biscrolled fibers fabricated thereby. | 11-05-2015 |
| 20150315661 | NON-INVASIVE DETECTION OF BLADDER CANCER BY FLOURESCENCE IN SITU HIBRIDIZATION OF AURORA A - We disclose a method of detecting bladder cancer in a patient, comprising isolating bladder cells from the patient's urine; hybridizing the bladder cells with a labelled DNA probe, wherein the probe recognizes at least a portion of the aurora kinase A gene, to yield a sample of bladder cells hybridized with the labeled DNA probe: and counting the number of bladder cells in the sample, the number of copies of the aurora kinase A gene in each bladder cell in the sample, and the number of bladder cells in the sample having at least a first threshold number of copies of the aurora kinase A gene. | 11-05-2015 |
| 20150315281 | ANTI-OX40 ANTIBODIES AND METHODS OF USING THE SAME - Human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human OX40 are disclosed. Preferred antibodies have high affinity for OX40 receptor and activate the receptor in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, are useful for modulating receptor activity, e.g., in a human subject suffering from a disorder in which OX40 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies are provided, and methods of synthesizing the recombinant human antibodies, are also provided. | 11-05-2015 |
| 20150308018 | FABRICATION AND APPLICATION OF NANOFIBER RIBBONS AND SHEETS AND TWISTED AND NON-TWISTED NANOFIBER YARNS - The present invention is directed to nanofiber yarns, ribbons, and sheets; to methods of making said yarns, ribbons, and sheets; and to applications of said yarns, ribbons, and sheets. In some embodiments, the nanotube yarns, ribbons, and sheets comprise carbon nanotubes. Particularly, such carbon nanotube yarns of the present invention provide unique properties and property combinations such as extreme toughness, resistance to failure at knots, high electrical and thermal conductivities, high absorption of energy that occurs reversibly, up to 13% strain-to-failure compared with the few percent strain-to-failure of other fibers with similar toughness, very high resistance to creep, retention of strength even when heated in air at 450° C. for one hour, and very high radiation and IJV resistance, even when irradiated in air. Furthermore these nanotube yarns can be spun as one micron diameter yarns and plied at will to make two-fold, four-fold, and higher fold yarns. Additional embodiments provide for the spinning of nanofiber sheets having arbitrarily large widths. In still additional embodiments, the present invention is directed to applications and devices that utilize and/or comprise the nanofiber yarns, ribbons, and sheets of the present invention. | 10-29-2015 |
| 20150306160 | ONCOLYTIC ADENOVIRUS ARMED WITH THERAPEUTIC GENES - The present invention involves compositions and methods for treating cancer using a mutant adenovirus comprising a polynucleotide encoding a therapeutic polypeptide that is targeted to cells with a mutant retinoblastoma pathway. The mutant adenovirus is able to kill the tumor cells without harming cells with a wild type retinoblastoma pathway. | 10-29-2015 |
| 20150297631 | TUSC2 THERAPIES - A method for predicting a subject's response to a TUSC2 therapy is provided. In particular, a subject's response is predicted based on the proportion of cancers cells that are apoptotic. Also provided is a method of treating a subject previously predicted to have a favorable response with a TUSC2 therapy. Methods for treating cancer by administration of a TUSC2 therapeutic in conjunction with an EGFR inhibitor and/or a protein kinase inhibitor are also disclosed. Kits and reagents for use in TUSC2 therapy are provided. | 10-22-2015 |
| 20150292112 | METHODS OF FORMING GRAPHENE SINGLE CRYSTAL DOMAINS - A method of forming graphene single crystal domains on a carbon substrate is described. | 10-15-2015 |
| 20150292030 | METHODS OF CHARACTERIZING AND TREATING MOLECULAR SUBSET OF MUSCLE-INVASIVE BLADDER CANCER - The present application discloses a method of diagnostic testing of primary tumors, circulating tumor cells, serum, and urine to detect high-risk bladder cancers. These results have immediate implications for prognostication and the clinical management of muscle-invasive bladder cancer. | 10-15-2015 |
| 20150284716 | METHOD FOR SINGLE CELL SEQUENCING OF MIRNAS AND OTHER CELLULAR RNAS - Provided herein are methods for single cell sequencing of miRNAs and other low abundance and/or or short cellular RNAs. | 10-08-2015 |
| 20150275289 | Method for Accurate Sequencing of DNA - DNA is sequenced by (a) independently sequencing first and second strands of a dsDNA to obtain corresponding first and second sequences; and (b) combining the first and second sequences to generate a consensus sequence of the dsDNA. By independently sequencing first and second strands the error probability of the consensus sequence approximates a multiplication of those of the first and second sequences. | 10-01-2015 |
| 20150274757 | Branched Siloxanes And Methods For Synthesis - The present invention describes branched and functionalized siloxanes and methods for making such compounds. The compounds have a variety of uses. One preferred application is as novel planarizing material for lithography, in which case functionalized branched siloxane, such as an epoxy-modified branched siloxane is particularly useful. | 10-01-2015 |
| 20150273088 | ZAPRINAST ANALOGUES AS GLUTAMINASE INHIBITORS AND METHODS TO PREDICT RESPONSE THERETO - Zaprinast has been discovered to have activity against glutaminase 1, an important metabolic enzyme in selected cancers, for example, glutamine-dependent cancer types. Thus, glutamine-dependent cancer types, such as IDH1/2 gain-of-function mutant cancers or GLI1 overexpressing cancers, may be particularly sensitive to Zaprinast analogues. | 10-01-2015 |
| 20150266955 | DETECTION AND TREATMENT OF NON-DERMAL FIBROSIS - The invention relates to methods for the diagnosis, prognosis, and treatment of non-dermal fibrosis, including lung (or pulmonary) fibrosis. | 09-24-2015 |
| 20150261090 | Ordering Block Copolymers - A method for ordering block copolymers including forming a first layer having a first preference mode; and providing a reactive agent in selected regions of the first layer that modifies the selected regions to a second preference mode, wherein the selected regions define other regions of the first layer retaining the first preference mode thereby forming an alignment layer for block copolymers. | 09-17-2015 |
| 20150250864 | ANTI-CANCER VACCINES - The present provides tumor-associated antigens and their use as vaccines for treating and limiting cancers in a patient. In specific aspects, HERV type K envelope proteins and peptides are provided. Such proteins and peptides can be used to elicit specific immune responses—both humoral and cellular—that target tumor cells expressing the HERV type K envelope protein. | 09-10-2015 |
| 20150240110 | Surface Treatments for Alignment of Block Copolymers - The present invention relates to a method the synthesis and utilization of random, cross-linked, substituted polystyrene copolymers as polymeric cross-linked surface treatments (PXSTs) to control the orientation of physical features of a block copolymer deposited over the first copolymer. Such methods have many uses including multiple applications in the semi-conductor industry including production of templates for nanoimprint lithography. | 08-27-2015 |
| 20150231357 | SYSTEMS AND METHODS FOR GAS MIXTURE DELIVERY TO HUMANS INSIDE AN MRI SCANNER - Systems and methods for delivery of gas mixtures to humans inside an MRI scanner, including while monitoring and recording physiological parameters. | 08-20-2015 |
| 20150226725 | BLOOD COAGULOMETER AND METHOD - An apparatus for determining blood clotting capacity comprises an actuator to cyclically move a member within a sample of blood received in a well in a tray and one of a deflection sensor and a position sensor to determine the position of the wetted member upon being acted upon by the actuator. The theoretical position of the wetted member, as determined using a known actuator force and wetted member physical data, is compared to the sensed deflection or position of the wetted member, and the resistance to movement of the wetted member caused by the blood is determined and correlated to a clotting capacity. | 08-13-2015 |
| 20150198614 | Beclin 1 Phosphorylation - Antibodies specific for human Beclin 1 protein phosphorylated Ser234, Ser295, Tyr229, Tyr233 or Try352 are useful in diagnosing diseases such as cancer and impaired autophagy. The invention further relates to human Beclin 1 mutated at Ser234, Ser295, Tyr229, Tyr233 or Try352 with a phospho-silencing residue and uses thereof. | 07-16-2015 |
| 20150197908 | SYSTEMS, APPARATUSES AND METHODS FOR ASSESSING SOIL HEAVE - A method of assessing soil heave includes providing a plurality of determined values of a shear modulus of soil, the determined values being values of the shear modulus of the soil at different times; and determining a change over time in the shear modulus of the soil, based on the plurality of determined values of the shear modulus of the soil. The soil may have been treated by adding a stabilizer to the soil. The soil may be hydrated. A system for assessing soil heave includes a bender element disposed in soil, for determining a change over time of a shear modulus of the soil, and a time domain reflectometer probe disposed in the soil, for determining a change over time of moisture content of the soil. The determined change over time of the shear modulus and the determined change over time of the moisture content are used to assess heaving of the soil. | 07-16-2015 |
| 20150196523 | ANTIMICROBIAL COMPOSITIONS COMPRISING GLYCERYL NITRATES - Provided are antimicrobial solutions comprising a glyceryl nitrate (e.g., glyeryl trinitrate) in combination with a chelator (e.g., citrate), a peroxide, a fatty acid, and/or an alcohol (e.g., ethanol). In various aspects these components may synergistically act to kill or reduce the growth of microbes, such as bacteria or fungi, present in a biofilm. | 07-16-2015 |
| 20150191987 | Underwater Noise Abatement Apparatus and Deployment System - A deployable underwater noise abatement system allowing packing and deploying an organized set of grouped resonators is disclosed. The system allows relatively compact storage and transportation of the noise abatement apparatus when not in use, then, when deployed, the apparatus can be lowered into the water and extended. | 07-09-2015 |
| 20150191546 | MONOCLONAL ANTIBODIES FOR USE IN DIAGNOSIS AND THERAPY OF CANCERS AND AUTOIMMUNE DISEASE - The specification describes the sequences for antibodies that recognize the HLA-A2-restricted peptide PR-1 in the context of HLA presentation on the surface of cancer cells. Use of these antibodies in the diagnosis and treatment of cancer and immune-related diseases are also provided. | 07-09-2015 |
| 20150182583 | METHODS FOR TREATMENT AND PREVENTION OF TAUOPATHIES BY INHIBITING ENDOTHELIN RECEPTORS - Compositions and methods of treatment of tauopathies are provided. In some embodiments, an antagonist of endothclin receptor A (ETA) and endothelin receptor B (ETB) may be administered to a subject to reduce tau production or accumulation, e.g., in astrocytes. The antagonist may be a dual ETA and ETB receptor antagonist. In some aspects, methods are provided for the treatment of chemo-brain, hypoxia, brain ischemia, surgical dementia, glioblastoma, or a traumatic brain injury (TBI). | 07-02-2015 |
| 20150178959 | BACKPROJECTION APPROACH FOR PHOTOACOUSTIC IMAGE RECONSTRUCTION - Various examples are provided for photoacoustic image reconstruction and processing utilizing a backprojection approach. In one example, among others, a method for producing an image with a photoacoustic imaging system includes scanning an object with a plurality of light beams, detecting a plurality of acoustic signals produced by the light beams, and generating a reconstructed image from the plurality of acoustic signals by filtered backprojection (FBP) that utilizes a weighted ramp filter. In another example, a system includes a plurality of acoustic detector units and a processing unit. The acoustic detector units can receive an acoustic wave and convert it to time dependent electrical signals. The processing unit can reconstruct an image of the subject from the time-dependent electrical signals by FBP that utilizes a weighted ramp filter. In another example, non-transitory computer readable medium stores a program that can cause a processing unit to reconstruct an image. | 06-25-2015 |
| 20150175660 | CONTROLLED MODULATION OF AMINO ACID SIDE CHAIN LENGTH OF PEPTIDE ANTIGENS - The invention provides a method for the creation of peptide antigens comprising epitopes with at least a first modification comprising a shortened or lengthened amino acid side chain. By extension or shortening of the side chain with CH3/CH2 groups, for example, made by computer assisted modeling of the tumor antigen (peptide) bound in the MHC-I-groove, immunogenicity can be improved with minimal modification of adjacent tertiary structure, thereby avoiding cross-reactivity. Provided by the invention are methods of creating such antigens, as well as methods for therapeutic or prophylactic treatment of various conditions comprising administration of the antigens. | 06-25-2015 |
| 20150157715 | Photokinetic Ocular Drug Delivery Methods and Apparatus - The present invention relates generally to transscleral, transcorneal, and transocular delivery of biologically active substances through the tissues, blood vessels and cellular membranes of the eyes of patients without causing damage to the cellular surface, tissue or membrane. The invention provides compositions and methods for enhanced transscleral, transcorneal and transocular delivery of biologically active substances using pulsed incoherent light, and particularly the transcleral, transcorneal or transocular delivery of high molecular weight biologically active substances to a patient using pulsed incoherent light. The invention further provides a device for the application of the pulsed incoherent light to cellular surfaces and membranes of the eye of a subject using those compositions and methods. | 06-11-2015 |
| 20150157662 | GENERATION OF INDUCED PLURIPOTENT STEM CELLS BY MODULATION OF DELTA-NP63 OR DCGR8 - The present invention generally concerns particular methods and compositions for generation of induced pluripotent stem cells. In particular aspects, induced pluripotent stem cells are generated from adult somatic cells following downregulation of a particular gene of interest. In some embodiments, induced pluripotent stem cells are generated from keratinocytes upon downregulation of ΔNp63 or DGCR8. | 06-11-2015 |
| 20150152504 | METHOD FOR DETERMINING COMPLETE RESPONSE TO ANTICANCER THERAPY - Methods for identifying patients with molecular or complete remission of colorectal cancer following therapy a fluorocytidine derivative and a COX-2 enzyme inhibitor by quantifying CD 133 expression levels. Methods for detecting cancer stem cells by quantifying serum CD 133 RNA levels are also provided. | 06-04-2015 |
| 20150147573 | NANOFIBER RIBBONS AND SHEETS AND FABRICATION AND APPLICATION THEREOF - The present invention is directed to nanofiber yarns, ribbons, and sheets; to methods of making said yarns, ribbons, and sheets; and to applications of said yarns, ribbons, and sheets. In some embodiments, the nanotube yarns, ribbons, and sheets comprise carbon nanotubes. Particularly, such carbon nanotube yarns of the present invention provide unique properties and property combinations such as extreme toughness, resistance to failure at knots, high electrical and thermal conductivities, high absorption of energy that occurs reversibly, up to 13% strain-to-failure compared with the few percent strain-to-failure of other fibers with similar toughness, very high resistance to creep, retention of strength even when heated in air at 450° C. for one hour, and very high radiation and UV resistance, even when irradiated in air. Furthermore these nanotube yarns can be spun as one micron diameter yarns and plied at will to make two-fold, four-fold, and higher fold yarns. Additional embodiments provide for the spinning of nanofiber sheets having arbitrarily large widths. In still additional embodiments, the present invention is directed to applications and devices that utilize and/or comprise the nanofiber yarns, ribbons, and sheets of the present invention. | 05-28-2015 |
| 20150126563 | SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME - Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein. | 05-07-2015 |
| 20150125323 | FREE PISTON LINEAR MOTOR COMPRESSOR AND ASSOCIATED SYSTEMS OF OPERATION - A linear motor compressor including a compressor housing and a cylinder housing having a plurality of opposing compression chambers. A piston freely reciprocates within the cylinder housing using a linear electric motor. | 05-07-2015 |
| 20150123678 | PASSIVE WIRELESS SELF-RESONANT SENSOR - A sensor for detecting one or more materials includes a substrate, a passivation layer formed on the substrate, a self-resonant structure and a high surface area material disposed on the passivation layer. The self-resonant structure includes a planar spiral inductor and a plurality of planar interdigitated capacitor electrodes disposed within the passivation layer. The planar spiral inductor includes an electrically conductive trace formed on the substrate in a planar spiral pattern having at least two turns and an inter-winding space between parallel segments of the electrically conductive trace. The plurality of planar interdigitated capacitor electrodes are electrically connected to the electrically conductive trace of the planar spiral inductor and formed on the substrate within the inter-winding space of at least one outermost turn of the planar spiral inductor. The high surface area material includes a conformal polymer coating to increase a sensitivity to the one or more materials. | 05-07-2015 |
| 20150119947 | Method and Apparatus for Determining Cardiac Performance in a Patient - An apparatus for determining heart transplant rejection of a heart in a patient includes at least two electrodes adapted to be sewn into the heart that span the left ventricle. The apparatus includes a voltage generator adapted to be inserted in the patient which generates a voltage to the two electrodes and senses the resulting voltage from the two electrodes. A method for determining heart transplant rejection of a heart in a patient. A pacemaker for a patient (including bi-ventricular pacing and AICDs). The pacemaker includes an RV lead having four electrodes adapted to be inserted into the RV apex. The pacemaker includes a voltage generator which generates a voltage signal to the electrodes and senses the instantaneous voltage along the length of the RV and determines the real and imaginary components to remove the myocardial components of the septum and RV free wall to determine absolute RV blood volume. The pacemaker includes a battery connected to the voltage generator. The pacemaker includes a defibrillator connected to the battery. The pacemaker can also be a bi-ventricular pacemaker to restore RV and LV synchrony during contraction. A method for assisting a heart of a patient. | 04-30-2015 |
| 20150119730 | Method and Apparatus for Determining Cardiac Performance in a Patient with a Conductance Catheter - An apparatus for determining cardiac performance in the patient. The apparatus includes a conductance catheter for measuring conductance and blood volume in a heart chamber of the patient. The apparatus includes a processor for determining instantaneous volume of the ventricle by applying a non-linear relationship between the measured conductance and the volume of blood in the heart chamber to identify mechanical strength of the chamber. The processor is in communication with the conductance catheter. Methods for determining cardiac performance in a patient. Apparatuses for determining cardiac performance in a patient. | 04-30-2015 |
| 20150118181 | Concurrent Chemotherapy and Immunotherapy - The concurrent administration of chemotherapy and immunotherapy has been considered a contraindication because of the concern that the induced lymphopenia would ablate therapeutic efficacy of immunotherapy. Temozolomide has been shown to be an effective chemotherapeutic for patients with malignant gliomas and to deprive patients with glioblastoma (GBM) patients of this agent in order to treat with immunotherapy is controversial. Despite conventional dogma, we demonstrate that both chemotherapy and immunotherapy can be delivered concurrently without negating the effects of immunotherapy. In fact, the temozolomide induced lymphopenia may actually be synergistic with a peptide vaccine. | 04-30-2015 |
| 20150116548 | MAXIMIZING PERCEPTUAL QUALITY AND NATURALNESS OF CAPTURED IMAGES - A method, system and computer program product for improving the perceptual quality and naturalness of an image captured by an image acquisition device (e.g., digital camera). Statistical features of a scene being imaged by the image acquisition device are derived from models of natural images. These statistical features are measured and mapped onto the control parameters (e.g., exposure, ISO) of the digital acquisition device. By mapping these statistical features onto the control parameters, the perceptual quality and naturalness of the scene being imaged may be based on the values of these control parameters. As a result, these control parameters are modified to maximize the perceptual quality and naturalness of the scene being imaged. After modification of these control parameters, the image is captured by the image acquisition device. In this manner, the perceptual quality and naturalness of the image captured by the image acquisition device is improved. | 04-30-2015 |
| 20150110848 | ADSORPTION OF PROTEINS ON CONDUCTING SURFACES UPON APPLICATION OF EXTERNAL POTENTIAL - The present invention provides methods for adsorbing a protein onto a conductive solid substrate, comprising the application of an external potential to the solid substrate greater than +500 mV vs. the Ag/AgCl/Cl | 04-23-2015 |
| 20150105301 | ALKOXY CARBOXYLATE SURFACTANTS - Provided herein are inter alia novel compositions and methods having application in a variety of fields including the field of enhanced oil recovery, the cleaning industry as well as groundwater remediation. In particular, the alkoxy carboxylate compounds and mixtures thereof presented herein can be used, inter alia, for the recovery of a large range of crude oil compositions from challenging reservoirs. | 04-16-2015 |
| 20150100599 | User-Powered Recommendation System - Recommendation systems are widely used in Internet applications. In current recommendation systems, users only play a passive role and have limited control over the recommendation generation process. As a result, there is often considerable mismatch between the recommendations made by these systems and the actual user interests, which are fine-grained and constantly evolving. With a user-powered distributed recommendation architecture, individual users can flexibly define fine-grained communities of interest in a declarative fashion and obtain recommendations accurately tailored to their interests by aggregating opinions of users in such communities. By combining a progressive sampling technique with data perturbation methods, the recommendation system is both scalable and privacy-preserving. | 04-09-2015 |
| 20150080878 | DEVICE AND METHOD FOR TISSUE REMOVAL - Exemplary embodiments are directed to devices and methods for tissue removal. Exemplary embodiments can be configured for mechanical dissection as well as suction to grasp, resect and collect all or part of a target tissue. Exemplary embodiments may also comprise elements for cauterization of tissue and coagulation of blood vessels. | 03-19-2015 |
| 20150073033 | BIOMARKERS FOR CANCER CHARACTERIZATION AND TREATMENT - Composition and methods for characterizing cancer cells by determining a marker of PKM2 activity. For example, methods are provided for predicting a patient response to a NF-κB, PKCε, PKM2, MEK/ERK, Pin1 or Src inhibitor therapy. Methods for treating patients with such therapies are likewise provided. Phosphorylation selective β-catenin, MLC2, histone H3, Bub3, and PKM2-binding antibodies are also provided. | 03-12-2015 |
| 20150064709 | MODULATING GENE EXPRESSION WITH agRNA AND GAPMERS TARGETING ANTISENSE TRANSCRIPTS - Gene expression is selectively modulated in the genome of a mammalian cell determined to be in need thereof by determining the presence of an encoded antisense transcript overlapping a promoter of the target gene; contacting the transcript with an agRNA or gapmer complementary to a portion of the transcript upstream relative to the transcription start site of the gene; and detecting a resultant modulation of expression of the target gene. | 03-05-2015 |
| 20150064160 | ENGINEERED PRIMATE CYSTINE/CYSTEINE DEGRADING ENZYMES AS ANTINEOGENIC AGENTS - Methods and compositions related to the engineering of a protein with L-cyst(e)ine degrading enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-γ-lyase comprising one or more amino acid substitutions and capable of degrading L-cyst(e)ine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with L-cyst(e)ine using the disclosed proteins or nucleic acids. | 03-05-2015 |
| 20150064159 | ENGINEERED PRIMATE L-METHIONINASE FOR THERAPEUTIC PURPOSES - Methods and compositions relating to the engineering of an improved protein with methionine-γ-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-γ-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids. | 03-05-2015 |
| 20150064154 | ADMINISTRATION OF KYNURENINE DEPLETING ENZYMES FOR TUMOR THERAPY - Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids. | 03-05-2015 |
| 20150060957 | THREE-DIMENSIONAL GATE-WRAP-AROUND FIELD-EFFECT TRANSISTOR - A three-dimensional Gate-Wrap-Around Field-Effect Transistor (GWAFET). The GWAFET includes a substrate of III-V semiconductor material. The GWAFET further includes one or more channel layers with a gate wrapped around these one or more channel layers. Additionally, the GWAFET includes a barrier layer residing on the top channel layer with a layer of doped III-V semiconductor material residing on each end of the barrier layer. A source and drain contact are connected to the layer of doped III-V semiconductor material as well as to the multiple channels in the embodiment with the GWAFET including multiple channel layers. By having such a structure, integration density is improved. Furthermore, electrostatic control is improved due to gate coupling, which helps reduce standby power consumption. Furthermore, by using III-V semiconductor material as opposed to silicon, the current drive capacity is improved. | 03-05-2015 |
| 20150054135 | SELF-ALIGNED MASKS AND METHODS OF USE - The disclosure relates to a method for forming a nanoscale structure by forming a pattern on a selectively etched layer located on top of a substrate using lithography, wherein the pattern results a gap having sidewalls, performing RIE on the gap having sidewalls, wherein RIE results in the formation of a self-aligned mask on the bottom wall of the gap with unprotected regions on the bottom wall of the gap near the junctions with the sidewalls, and wet etching the gap having a self-aligned mask and unprotected regions to remove the substrate under the unprotected regions to form a nanoscale structure in the substrate. | 02-26-2015 |
| 20150053929 | VERTICAL III-V NANOWIRE FIELD-EFFECT TRANSISTOR USING NANOSPHERE LITHOGRAPHY - A vertical III-V nanowire Field-Effect Transistor (FET). The FET includes multiple nanowires or nanopillars directly connected to a drain contact, where each of the nanopillars includes a channel of undoped III-V semiconductor material. The FET further includes a gate dielectric layer surrounding the plurality of nanopillars and a gate contact disposed on a gate metal which is connected to the gate dielectric layer. Additionally, the FET includes a substrate of doped III-V semiconductor material connected to the nanopillars via a layer of doped III-V semiconductor material. In addition, the FET contains a source contact directly connected to the bottom of the substrate. By having such a structure, electrostatic control and integration density is improved. Furthermore, by using III-V materials as opposed to silicon, the current drive capacity is improved. Additionally, the FET is fabricated using nanosphere lithography which is less costly than the conventional photo lithography process. | 02-26-2015 |
| 20150048681 | MULTIPLE-INPUT ISOLATED PUSH-PULL CONNECTED POWER CONVERTERS - A multiple-input power converter transferring energy from multiple input sources to a load. The multiple-input power converter utilizes a push-pull converter that isolates loads from sources by a transformer in the output rectifier stage. The isolation increases the safety of the system and provides a wider range of sources-to-load voltage transfer ratios. Furthermore, the multiple-input power converter utilizes a lower number of components in comparison to previously designed multiple-input power converter topologies as well as has a lower control circuit implementation cost when compared to previously designed soft-switching multiple-input power converters. | 02-19-2015 |
| 20150047846 | METHOD OF IMPROVING HYDRAULIC FRACTURING BY DECREASING FORMATION TEMPERATURE - A method for producing fractures in a formation to release hydrocarbons (such as a hydrocarbon gas or liquid) from the formation is disclosed. The method comprises reducing the in-situ temperature at a location in a formation having a first temperature by contacting the location with a first fluid and contacting the location with a fracturing fluid to produce fractures in the formation while the location is at a second temperature below the first temperature to release hydrocarbons from the formation. The method can include using an endothermic process to reduce the temperature at the location in the formation. | 02-19-2015 |
| 20150034077 | PULSE DRUG NEBULIZATION SYSTEM, FORMULATIONS THEREFORE, AND METHODS OF USE - Liquid nebulizer apparatus, systems, and formulation compositions, as well as systems for the nebulized, aerosol delivery of such compositions, for the administration and insufflation of medicinal aerosols into the pulmonary system of a mammal are described. The nebulizing apparatus and system can effectively aerosolize a variety of viscosities of medicinal liquid drug carriers, including those made up of oil, water, or emulsions of oil and water. Drugs dissolved or suspended in the compositions and formulations described and adapted for use herein are not damaged or denatured by the nebulization process when the nebulizer described is used. Further, the nebulization system itself can be adapted for use with both mechanically assisted pulmonary ventilation systems as well as hand-held inhalers and nose/mouth face masks for use in pulmonary drug delivery. | 02-05-2015 |
| 20150024425 | Apparatuses And Methods For Forming Wounds In Cell Layers - In one embodiment, an apparatus for forming wounds in cell layers includes a base that includes a guide track, and a sliding member adapted to fit within the guide track, the sliding member including a scratching element holder adapted to secure a scratching element in a position in which it contacts a cell layer, wherein the sliding member is further adapted to slide along the guide track to drag the scratching element through the cell layer. | 01-22-2015 |
| 20150017651 | PERSONALIZED MEDICINE FOR THE PREDICTION OF THERAPY TARGETING THE HEDGEHOG PATHWAY - Methods and composition for tumor therapy, especially esophageal adenocarcinoma (EAC), are described. For example, in certain aspects methods for determining Hedgehog and mTOR signaling pathway status to select patients for administering a combination therapy of Hedgehog and mTOR signaling inhibitors are described. Furthermore, the invention provides compositions that involve testing kits for determining signaling status. | 01-15-2015 |
| 20140378529 | COLLATERAL GENE INACTIVATION BIOMARKERS AND TARGETS FOR CANCER THERAPY - Methods for treating a subject determined to have a cancer comprising a heterozygous inactivation of a housekeeping gene (or a homozygous deletion of a functionally redundant housekeeping gene) by treating the subject with an inhibitor of the gene. For example, a subject having a cancer with an ENO gene deletion can be treated with a glycolysis inhibitor, such as an enolase inhibitor. In some aspects, a subject having a cancer with an ARS gene deletion can be treated with an ARS inhibitor. | 12-25-2014 |
| 20140377339 | TUSC2 THERAPIES - A method for predicting a subject's response to a TUSC2 therapy is provided. In particular, a subject's response is predicted based on the proportion of cancers cells that are apoptotic. Also provided is a method of treating a subject previously predicted to have a favorable response with a TUSC2 therapy. Methods for treating cancer by administration of a TUSC2 therapeutic in conjunction with an EGFR inhibitor and/or a protein kinase inhibitor are also disclosed. Kits and reagents for use in TUSC2 therapy are provided. | 12-25-2014 |
| 20140377294 | ADENOVIRUSES EXPRESSING HETEROLOGOUS TUMOR-ASSOCIATED ANTIGENS - The present invention is directed to adenoviruses for use in cancer therapy which comprise one or more heterologous nucleic acid sequences encoding a tumor antigen, whereby the adenovirus expresses the tumor antigen(s) on its surface. | 12-25-2014 |
| 20140377221 | BIOMARKERS AND COMBINATION THERAPIES USING ONCOLYTIC VIRUS AND IMMUNOMODULATION - The invention disclosed herein describes biomarkers useful for prognosis, selection and monitoring of oncolytic virus therapy for patients with various types of cancer. In particular, the present invention provides identification of proteins whose expression patterns are strongly predictive of the outcome of oncolytic virus therapy in a patient with cancer. The present invention provides a method for identifying and selecting cancer patients who are likely to be non-responsive to onocolytic virus therapy. These patients can be co-administered an agent that stimulates a cell-mediated immune response in the patient with the oncolytic virus or can be administered a therapy other than oncolytic virus therapy. | 12-25-2014 |
| 20140377181 | MOLECULES WITH EXTENDED HALF-LIVES, COMPOSITIONS AND USES THEREOF - The present invention provides molecules, including IgGs, non-IgG immunoglobulins, proteins and non-protein agents, that have increased in vivo half-lives due to the presence of an IgG constant domain, or a portion thereof that binds the FcRn, having one or more amino acid modifications that increase the affinity of the constant domain or fragment for FcRn. Such proteins and molecules with increased half-lives have the advantage that smaller amounts and or less frequent dosing is required in the therapeutic, prophylactic or diagnostic use of such molecules. | 12-25-2014 |
| 20140371101 | PARP Substrates and Biomarkers - PARylated proteins are enriched by treating cell lysates comprising PARylated proteins and DNA/RNA with an endonuclease that cleaves the DNA/RNA but not the PAR; and separating the PARylated proteins from the cleaved DNA/RNA. PARylation sites are labeled by eluting PARylated proteins from a PAR-affinity substrate with a nucleophilic amine exchange reactant, wherein the reactant labels PARylation sites of the proteins. Specific binding agents are identified by screening compounds for specific binding to a PARylated protein disclosed herein; and identifying one of the compounds as a specific binder of the protein. Antibodies which specifically bind PARylation sites are also disclosed. | 12-18-2014 |
| 20140364347 | DI-FUNCTIONAL ANIONIC SURFACTANTS FOR ENHANCED OIL RECOVERY - The present invention describes the synthesis and use of cleavable di-functional anionic surfactants for enhanced oil recovery applications and/or the use of sacrificial surfactants. | 12-11-2014 |
| 20140363376 | MOLECULAR DESIGN TOWARD DUAL-MODALITY PROBES FOR RADIOISOTOPE-BASED IMAGING (PET OR SPECT) AND MRI - In some aspects, the present invention provides novel ligands, which may be used to make novel dual-modality imaging agents, for example, for PET and MRI imaging. In further aspects, by the present disclosure also provides methods of use and methods of preparation of the novel ligands, metal complexes, and imaging agents thereof. | 12-11-2014 |
| 20140358229 | Medical Devices, Apparatuses, Systems, and Methods With Magnetic Shielding - Embodiments of apparatuses, and methods and systems including apparatuses, configured to be magnetically coupled to a medical device within a body cavity of a patient. Some embodiments include one or more elements comprising at least one of a magnetically-attractive and magnetically-chargeable material; and a bumper extending around the one or more elements and configured to reduce the strength of a magnetic field of the one or more elements. | 12-04-2014 |
| 20140350645 | Altering Temperature in a Mammalian Body - The present application relates to systems and methods for altering temperature in a mammalian body. Optionally, the systems and methods can be used to lower or raise core body temperature of a mammalian subject. Optionally, the systems and methods can be used to lower or raise the temperature of glabrous skin of a mammalian subject. | 11-27-2014 |
| 20140349860 | IDENTIFYING PEPTIDES AT THE SINGLE MOLECULE LEVEL - The present invention relates to methods for identifying amino acids in peptides. In one embodiment, the present invention contemplates labeling the N-terminal amino acid with a first label and labeling an internal amino acid with a second label. In some embodiments, the labels are fluorescent labels. In other embodiments, the internal amino acid is lysine. In other embodiments, amino acids in peptides are identified based on the fluorescent signature for each peptide at the single molecule level. | 11-27-2014 |
| 20140349402 | CAR+ T CELLS GENETICALLY MODIFIED TO ELIMINATE EXPRESSION OF T-CELL RECEPTOR AND/OR HLA - The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising disrupted T cell receptor and/or HLA and comprising a chimeric antigen receptor. In certain embodiments, the compositions are employed allogeneically as universal reagents for “off-the-shelf treatment of medical conditions such as cancer, autoimmunity, and infection. In particular embodiments, the T cell receptor-negative and/or HLA-negative T cells are generated using zinc finger nucleases, for example. | 11-27-2014 |
| 20140348902 | TCL1 PEPTIDES FOR IMMUNOTHERAPY - Provided are TCL1 peptides that bind to MHC I (HLA-A2) on tumor cells or other antigen-presenting cells and are recognized by T-cell receptors on T cells. The TCL1 peptides may be therapeutically used to treat a cancer, such as a B cell malignancy, leukemia, or lymphoma. Methods for expanding a population of T cells that target TCL1 are also provided. | 11-27-2014 |
| 20140342291 | Novel Dual-Tone Resist Formulations And Methods - Dual tone photoresist formulations comprising a photoacid generator are described and employed in fabrication techniques, including methods of making structures on substrates, and more particularly, methods of making electronic devices (e.g. transistors and the like) on flexible substrates wherein two patterns are formed simultaneously in one layer of photoresist. | 11-20-2014 |
| 20140335549 | MEASURING CIRCULATING THERAPEUTIC ANTIBODY, ANTIGEN AND ANTIGEN/ANTIBODY COMPLEXES USING ELISA ASSAYS - The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone at least one course of immunotherapy. Yet further, levels of therapeutic antibody:antigen complexes, soluble antigens or soluble therapeutic antibodies may be measured and used to stage or monitor a hyperproliferative disease. | 11-13-2014 |
| 20140333197 | Compositions of Mercury Isotopes for Lighting - Described herein is a mercury sample that has an isotopic composition that differs from the naturally occurring distribution of isotopes. In various configurations of an isotopically tailored mercury sample, the fraction of one or more isotopes is increased or decreased with respect to the natural fraction(s). A example of a lighting device comprises an envelope, a buffer gas enclosed within the envelope, a isotopically tailored sample of mercury vapor, and a current injection mechanism configured to excite the mercury vapor to emit light. In various configurations, the lighting device emits radiation at a wavelength of 254 nm and/or at a wavelength of 185 nm. In various configurations, the lighting device envelope includes a fluorescent coating that is excited by ultraviolet (UV) light emitted by the mercury vapor. In various configurations, the lighting device provides improved efficiency as compared to lamps employing mercury with a naturally occurring isotope distribution. | 11-13-2014 |
| 20140329901 | COMPOUNDS FOR TREATMENT OF CELL PROLIFERATIVE DISEASES - The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as kinase inhibitors, cause the downregulation of c-myc, and inhibit the growth and survival of cancerous cell lines. | 11-06-2014 |
| 20140329287 | COMPOSITIONS AND METHODS FOR LIPID PRODUCTION - Described herein, inter alia, are compositions, oleagnious organisms, and methods useful for producing lipids, lipid precursors, and/or oleochemicals. | 11-06-2014 |
| 20140322303 | LIPOSOMAL CURCUMIN FOR TREATMENT OF DISEASES - The present invention provides compositions and methods for the treatment of a human patient. The methods and compositions of the present invention include composition for the efficient loading of curcumin, comprising: an amount of a curcuminoid:liposome complex effective to load curcumin into the liposome, wherein the curcuminoids has between 2 to 9 weight percent of the total composition and the curcuminoids are natural or synthetic. | 10-30-2014 |
| 20140319026 | SHORT CHAIN ALKYLAMINE ALKOXYLATE COMPOSITIONS - Provided herein are, inter alia, compositions including a surfactant and a novel compound useful in enhanced oil recovery. The compositions and methods provided herein may be particularly useful for oil recovery under a broad range of reservoir conditions (e.g. high to low temperatures, high to low salinity, highly viscous oils). | 10-30-2014 |
| 20140318958 | INTEGRATED ELECTRO-ANALYTICAL BIOSENSOR ARRAY - A biosensor pixel for measuring current that flows through the electrode surface in response to electrochemical interactions and a biosensor array architecture that includes such biosensor pixels. The biosensor pixel includes an electrode transducer configured to measure a current generated by electrochemical interactions occurring at a recognition layer placed directly on top of it in response to an electrical voltage placed across an electrode transducer-electrolyte interface. The biosensor pixel further includes a trans-impedance amplifier connected to the electrode transducer, where the trans-impedance amplifier is configured to convert the current into a voltage signal as the electrochemical interactions occur. Additionally, the biosensor pixel includes a 1-bit comparator coupled to the trans-impedance amplifier and a 1-bit digital-to-analog converter coupled to the 1-bit comparator, where the 1-bit digital-to-analog converter injects different levels of charge into an input of the trans-impedance amplifier at each cycle based on an output of the 1-bit comparator. | 10-30-2014 |
| 20140317999 | USE OF AMINES IN RECOVERY OF ACTIVE OILS - Provided herein, inter alia, are methods and compositions useful for heavy crude oil recovery. The emulsion compositions and non-surfactant aqueous compositions provided herein may be particularly useful for the recovery of heavy crude oils under a broad range of reservoir conditions (e.g. high to low temperatures, high to low salinity, highly viscous oils). | 10-30-2014 |
| 20140313562 | GRAPHENE/METAL NANOWIRE HYBRID TRANSPARENT CONDUCTIVE FILMS - A hybrid transparent conductive film, and methods for fabricating such hybrid transparent conductive films, involving the assembly of two-dimensional graphene-based materials with one-dimensional silver and/or copper nanowires with high optical transmittance and good electrical conductivity. The hybrid films are characterized by a good degree of control of the architecture at the nanoscale level, where the weakness(es) of each component are offset by the strengths of the other components. By rational design of the structure and using simple and locate-cost fabrication methods, hybrid films with sheet resistance of 26 ohm/sq and optical transmittance (at λ=550 nm) of 83% for reduced graphene oxide/silver nanowire films, and 64 ohm/sq and optical transmittance of 93.6% for monolayer graphene/silver nanowire films have been fabricated. These values are comparable to transparent conductive films based on indium tin oxide but are now able to be used in flexible electronics due to their good mechanical properties. | 10-23-2014 |
| 20140308276 | ANTI-OX40 ANTIBODIES AND METHODS OF USING THE SAME - Human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human OX40 are disclosed. Preferred antibodies have high affinity for OX40 receptor and activate the receptor in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, are useful for modulating receptor activity, e.g., in a human subject suffering from a disorder in which OX40 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies are provided, and methods of synthesizing the recombinant human antibodies, are also provided. | 10-16-2014 |
| 20140296836 | GOLD-IN-SILICON NANOASSEMBLY FOR THERMAL THERAPY AND METHODS OF USE - The present invention provides methods and compositions for the nanotechnology-based therapy of one or more mammalian diseases. Disclosed are gold-in-porous silicon nanoassemblies that are effective in the targeted and localized treatment of one or more human hyperproliferative disorders, including, for example, cancer of the breast. Methods of systemic administration of these nanoassembly vectors are disclosed that facilitate direct thermal ablative therapy of selected tissues using a localized application of near-infrared energy to the target site, wherein the gold-in-porous silicon nanoparticles release heat to destroy the surrounding cancerous tissue. | 10-02-2014 |
| 20140295483 | APPARATUS AND METHOD FOR IN-VITRO DRUG SCREENING FOR CANCER METASTASIS - The present invention includes an apparatus and methods for detecting cancer cell metastasis, the apparatus comprising: a multi-well plate for growing cells in tissue culture; one or more shafts, cones, or fins that fit within one or more of the wells of the multi-well plate and that can be positioned in close proximity to the bottom of the one or more wells; a rotational motor connected to drive the one or more shafts, cones, or fins to rotate, such that rotation of the shafts, cones, or fins creates fluid flow within the one or more wells; and a detector capable of measuring cells within the wells. | 10-02-2014 |
| 20140287437 | MAGNETIC SEPARATION OF CELLS - An apparatus, system, and method for magnetic separation of cells are disclosed. By combining inkjet printing technology and magnetic labeling of cells, accurate cell counts are obtained using an optical microscope. Mouse CD4+ lymphocytes are attached to micron sized magnetic beads and printed through a modified, commercial inkjet printer. The labeled cells are then attached to a glass slide covering a permanent magnet. Cell counts can be obtained by use of regular and inverted optical microscopes and imaging software. The magnetically-labeled beads are collected for evaluation on a modified polymer coupon that is placed in front of a permanent magnet and the unlabeled cells fall into an excess container. Flow cytometry results verify the presence of the CD4+ protein on the LBRM-33 lymphocytes membrane. Protein-specific attachment of magnetic microspheres to the lymphocytes is utilized for sorting CD4+ lymphocytes. | 09-25-2014 |
| 20140277070 | METHODS, COMPOSITIONS, AND DEVICES FOR THE OCCLUSION OF CAVITIES AND PASSAGEWAYS - Provided herein are methods, compositions, and devices for occluding cavities or passageways in a patient, in particular cavities or passageways in the cardiovascular system of a patient, such as the LAA of a patient's heart. The methods, compositions, and devices can be used to percutaneously occlude the LAA, decreasing the risk of thromboembolic events associated with AF. | 09-18-2014 |
| 20140275201 | IDENTIFICATION OF CANCER STEM CELL MARKERS AND USE OF INHIBITORS THEREOF TO TREAT CANCER - The present invention provides biomarkers of cancer stem cells, as well as cells that have undergone EMT. In addition, the present invention provides methods of treating patients determined to comprise cancer stem cells with PDGFR-β inhibitors to eliminate the cancer stem cells. Methods of predicting sensitivity to PDGFR-β inhibitors, monitoring efficacy of treatment, and determining a prognosis are also provided. | 09-18-2014 |
| 20140273210 | HIGH THROUGHPUT MECHANICAL STRAIN GENERATING SYSTEM FOR CELL CULTURES AND APPLICATIONS THEREOF - The present application relates to an adaptable cell culture system that allows the application of mechanical strain to cells in culture through the displacement of a stretchable cell culture substrate. The system can apply dynamically heterogeneous strains to simulate the complex in vivo strain profiles on cultured cells, the strains including simulation of physiologic waveform such as a simulation of normal or diseased physiological biphasic stretch of the cardiac cycle, a simulation of normal or diseased physiological arterial waveform, or a cyclic mechanical strain. The system is modular and compatible with commercially available cell culture plate formats and robotic liquid handling devices. The system has a variety of applications including screening compounds for cardio toxicity or therapeutic activity, and identifying drug target, all using cell culture under the mechanical strain applied by the system. | 09-18-2014 |
| 20140270638 | Rayleigh Reflectors And Applications Thereof - In one aspect, optical devices and components are described herein. In some embodiments, a device comprises a substrate and a grating layer disposed on the substrate, wherein the grating layer comprises a periodic grating structure and a sublayer beneath the grating structure and adjacent the substrate. In some cases, the sublayer has a small thickness compared to the wavelength of light incident on and/or coupled into the device. For example, the sublayer of a device described herein can have a thickness of less than about 200 nm. Moreover, devices and components described herein can exhibit both guided-mode resonance (GMR) effects and a Rayleigh anomaly and can be used to provide various optical components such as optical couplers, substrate wave couplers, and flat-top angular reflectors or flat-top angular filters. | 09-18-2014 |
| 20140268607 | Methods and Systems For Connecting Inter-Layer Conductors and Components in 3D Structures, Structural Components, and Structural Electronic, Electromagnetic and Electromechanical Components/Devices - The present invention provides systems and methods for creating interlayer mechanical or electrical attachments or connections using filaments within a three-dimensional structure, structural component, or structural electronic, electromagnetic or electromechanical component/device. | 09-18-2014 |
| 20140268604 | Methods and Systems For Embedding Filaments in 3D Structures, Structural Components, and Structural Electronic, Electromagnetic and Electromechanical Components/Devices - The present invention provides systems and methods for embedding a filament or filament mesh in a three-dimensional structure, structural component, or structural electronic, electromagnetic or electromechanical component/device by providing at least a first layer of a substrate material, and embedding at least a portion of a filament or filament mesh within the first layer of the substrate material such the portion of the filament or filament mesh is substantially flush with a top surface of the first layer and a substrate material in a flowable state is displaced by the portion of the filament and does not substantially protrude above the top surface of the first layer, allowing the continuation of an additive manufacturing process above the embedded filament or filament mesh. A method is provided for creating interlayer mechanical or electrical attachments or connections using filaments within a three-dimensional structure, structural component, or structural electronic, electromagnetic or electromechanical component/device. | 09-18-2014 |
| 20140263991 | METHODS AND APPARATUS FOR OPTICALLY ENCODED POSITION MULTIPLE-POINT SCINTILLATION DETECTOR USING A SINGLE COLLECTING LIGHT GUIDE - Various embodiments are described herein for a radiation dosimetry apparatus and associated methods for measuring radiation dose. In some embodiments, the apparatus includes multiple scintillating elements for detecting amounts of radiation dose at multiple points within a detection region. Each of the scintillating elements generates light in response to radiation interacting within their volume. A light guide combines the light generated by all of the scintillating elements as well as radiation-induced contaminated optical energy and transmits the combined light to a spectral analysis setup. Multi or hyper-spectral calibration technique allows calculating the dose or dose rate at the positions of the different scintillating elements. The calibration technique isolates the light produced by a given scintillating element from the other scintillating elements as well as any other source of radiation-induced contaminating light. | 09-18-2014 |
| 20140257144 | Rapid Pulse Electrohydraulic (EH) Shockwave Generator Apparatus and Methods for Medical and Cosmetic Treatments - Apparatuses and methods for electrohydraulic generation of shockwaves at a rate of between 10 Hz and 5 MHz, and/or that permit a user to view a region of a patient comprising target cells during application of generated shockwaves to the region. Methods of applying electro-hydraulically generated shockwaves to target tissues (e.g., for reducing the appearance of tattoos, treatment or reduction of certain conditions and/or maladies). | 09-11-2014 |
| 20140257121 | Method and Apparatus for Monitoring an Organ of a Patient - An apparatus for determining tissue versus fluid components of an organ include a detector that generates a detector signal based on electrical signals derived from tissue and fluid. The apparatus includes a signal processor in communication with the detector which subtracts in real time a tissue component from the detector signal and produces a fluid volume signal. A method for monitoring a patient's fluid volume of a patient's organ. An apparatus for monitoring a patient's organ. A method for monitoring a patient's organ. A method to piggyback an admittance system onto a AICD/Bi-ventricular Pacemaker for a heart of a patient, in particular a weakened heart having features consistent with congestive heart failure. An apparatus for monitoring an organ, such as a heart, lungs, brain, skeletal muscle, and bladder of a patient which includes a detector which detects the admittance of the organ. The apparatus includes a transmitter in communication with the detector which transmits a wireless signal indicative of the admittance of the organ. A method for monitoring an organ of a patient includes the steps of detecting with a detector the admittance of the organ. There is the step of transmitting with a transmitter in communication with the detector a wireless signal indicative of admittance of the organ. | 09-11-2014 |
| 20140248325 | CELL-FREE TISSUE REPLACEMENT FOR TISSUE ENGINEERING - The present invention is a natural, cell-free tissue replacement that does not require difficult or extensive preparation made by washing tissue replacement in a solution including one or more sulfobetaines and an anionic surface-active detergent and washing the tissue replacement in serial solutions of the buffered salt to remove excess detergent. The natural, cell-free tissue replacement may be a nerve graft that supports axonal regeneration, guides the axons toward the distal nerve end and/or is immunologically tolerated. Other forms of the invention are a composition and kit prepared by the method of making a native, cell-free tissue replacement. The present invention may be modified for use in diagnostic, therapeutic, and prophylactic applications. | 09-04-2014 |
| 20140243573 | OIL QUALITY USING A MICROPOROUS HOLLOW FIBER MEMBRANE - The present invention includes methods and systems for improving oil quality of a contaminated oil mixture by removing contaminants from a contaminated oil comprising the steps of: pretreating a membrane contactor system having a first and a second surface with an hydrophobic liquid, wherein the hydrophobic liquid is contacted to at least one of the first and second surfaces; obtaining a contaminated oil that comprises oil and lipophobic contaminants; contacting the contaminated oil onto a first surface of one or more membrane contactors to coalesce the oil on the first surface; and collecting the coalesced oil from the contaminated oil on the second surface of the membrane contactor. | 08-28-2014 |
| 20140241661 | SUBWAVELENGTH GRATING COUPLER - A method, system or device for configuring an optical coupling device including obtaining characteristics of an optical signal and ambient conditions for storage in memory, utilizing a processor for identifying an optimum effective subwavelength area refractive index and a grating period for the input signal and ambient characteristics stored in memory, and utilizing the processor for identifying a preferred filling factor for a transverse polarization. | 08-28-2014 |
| 20140240162 | Method and Apparatus for Detecting Subsurface Targets Using Data Inversion and a Temporal Transmission Line Model - A method and apparatus for detects one or more subsurface targets by receiving a reflectivity data from two or more subsurface reflectors using a ground penetrating radar. The two or more subsurface reflectors may include the one or more subsurface targets and a medium surrounding the one or more subsurface targets. An impedance data for the two or more subsurface reflectors is calculated by inverting the reflectivity data using a temporal transmission line model with a “layer-peeling” method. One or more constitutive parameters of the two or more subsurface reflectors are calculated based on the impedance data. The one or more subsurface targets are detected based on a change in the one or more constitutive parameters. | 08-28-2014 |
| 20140238679 | TRANSPORT OF HEAVY OIL - Provided herein are, inter alia, heavy crude oil emulsion compositions and methods of making the same. The compositions and methods provided herein are particularly useful for the transport of heavy crude oils. | 08-28-2014 |
| 20140238671 | PHENOL-ALKOXYLATE CO-SOLVENT SURFACTANT COMPOSITION - Provided herein are, inter alia, compositions including a surfactant and a phenol-alkoxylate co-solvent useful in enhanced oil recovery. The compositions and methods provided herein are particularly useful for oil recovery under a broad range of reservoir conditions (e.g. high to low temperatures, high to low salinity, highly viscous oils). | 08-28-2014 |
| 20140234026 | ASPHALTENE BASED PHOTOVOLTAIC DEVICES - Photovoltaic devices and methods of making the same, are disclosed herein. The cell comprises a photovoltaic device that comprises a first electrically conductive layer comprising a photo-sensitized electrode; at least one photoelectrochemical layer comprising metal-oxide particles, an electrolyte solution comprising at least one asphaltene fraction, wherein the metal-oxide particles are optionally dispersed in a surfactant; and a second electrically conductive layer comprising a counter-electrode, wherein the second electrically conductive layer comprises one or more conductive elements comprising carbon, graphite, soot, carbon allotropes or any combinations thereof. | 08-21-2014 |
| 20140230563 | SENSOR ASSEMBLY, METHOD, AND DEVICE FOR MONITORING SHEAR FORCE AND PRESSURE ON A STRUCTURE - Shear force and pressure on a structure are simultaneously monitored using signals received from antennas on the structure. The shear force on the structure is monitored using a signal received from a patch antenna on the structure, and the pressure on the structure is monitored using a signal received from a loop antenna on the structure. | 08-21-2014 |
| 20140221464 | Compositions and Methods for Treating Skeletal Myopathy - The present invention provides a method of preventing or treating a myopathy, such as a skeletal myopathy, comprising administering a modulator of a miRNA. In one embodiment, the skeletal myopathy is centronuclear myopathy. The modulator can be an agonist that promotes the expression, function or activity of a miR-133 family member. The miR-133 family member can be miR-133a or miR-133b. | 08-07-2014 |
| 20140220605 | VMP-LIKE SEQUENCES OF PATHOGENIC BORRELIA SPECIES AND STRAINS - The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic | 08-07-2014 |
| 20140219602 | Broadband, Group Index Independent, and Ultra-Low Loss Coupling into Slow Light Slotted Photonic Crystal Waveguides - The present invention provides a waveguide coupler configured to optically couple a strip waveguide to a first slot photonic crystal waveguide, wherein the slot photonic crystal waveguide has a lattice constant, an air hole diameter, a slot width and a first line defect waveguide width. The waveguide coupler includes a group reflective index taper having a second slot photonic crystal waveguide disposed between and aligned with the first slot photonic crystal waveguide and the strip waveguide. The second slot photonic crystal waveguide has a length, the lattice constant, the air hole diameter, the slot width, and a second line defect waveguide width that is substantially equal to the first line defect waveguide width adjacent to the first slot photonic crystal waveguide and decreases along the length of the second photonic crystal waveguide. | 08-07-2014 |
| 20140212664 | INORGANIC NANOWIRES - Provided in one embodiment is a method of forming an inorganic nanowire, comprising: providing an elongated organic scaffold; providing a plurality of inorganic nanoparticles attached to the organic scaffold along a length of the organic scaffold; and fusing the nanoparticles attached to the organic scaffold to form an inorganic nanowire. | 07-31-2014 |
| 20140206031 | Systems And Methods For High-Resolution Imaging - In one aspect, methods of imaging are described herein. In some embodiments, a method of imaging described herein comprises disposing a population of ultrasound-switchable fluorophores in a biological environment, the fluorophores having a switching threshold between an off state and an on state; exposing the biological environment to an ultrasound beam to create an activation region within the biological environment; switching at least one of the fluorophores within the activation region from the off state to the on state; exciting the at least one fluorophore with a beam of electromagnetic radiation; and detecting light emitted by the fluorophore. In some embodiments, the activation region has a maximum negative pressure and/or maximum temperature and the switching threshold of the at least one fluorophore is at least about 50 percent of the maximum negative pressure or at least about 50 percent of the maximum temperature of the activation region. | 07-24-2014 |
| 20140205544 | Cancer Treatment Comprising Therapeutics That Bind To Phosphatidylserine - Disclosed is the surprising discovery that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are specific, accessible and stable markers of the luminal surface of tumor blood vessels. The present invention thus provides aminophospholipid-targeted diagnostic and therapeutic constructs for use in tumor intervention. Antibody-therapeutic agent conjugates and constructs that bind to aminophospholipids are particularly provided, as are methods of specifically delivering therapeutic agents, including toxins and coagulants, to the stably-expressed aminophospholipids of tumor blood vessels, thereby inducing thrombosis, necrosis and tumor regression. | 07-24-2014 |
| 20140200329 | BISAMINOETHANETHIOL-TARGETING LIGAND CONJUGATES AND COMPOSITIONS - The invention provides, in a general sense, a new labeling strategy employing | 07-17-2014 |
| 20140200230 | COMPOSITIONS AND METHODS FOR INHIBITING REDOX-SENSITIVE GTPASES - The invention provides compositions for inhibiting a redox-sensitive GTPase protein, including a Rho or Rab family GTPase, comprising an effective amount of a redox-sensitive purine compound and an effective amount of a redox agent. The invention further provides methods of inhibiting a redox-sensitive GTPase protein, including a Rho or Rab family GTPase, by administering compositions of the invention. Methods of screening for compounds that inhibit a redox-sensitive GTPase protein, including compounds that target and inhibit Rho or Rab family GTPases, are further provided. | 07-17-2014 |
| 20140200192 | TOPOISOMERASE 2B AS A PREDICTOR OF SUSCEPTIBILITY TO ANTHRACYCLINE-INDUCED CARDIOTOXICITY - Biomarkers of anthracycline cardiotoxicity are provided. In certain aspects, methods are provided for determining whether a subject will develop cardiotoxicity upon treatment with an anthracycline, such as doxorubicin, by measuring the level of Top2b expression in the subject. In further aspects, methods of a treating a subjects with anthracycline therapeutics and cardioprotective agents are provided. | 07-17-2014 |
| 20140193506 | PROTECTION AGAINST INFLUENZA INFECTION BY GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR - Alveolar macrophages contribute to host defenses against influenza. Enhancing their function contributed to protection against influenza and other acute lethal pulmonary infections. Wild-type mice and Tg mice expressing GM-CSF in the lung were infected with influenza virus, and lung pathology, weight loss and mortality were measured. GM-CSF was also administered to lungs of wild-type mice that were infected with influenza virus. All Tg mice expressing GM-CSF in the lungs survived with greatly reduced weight loss and lung injury and histologic evidence of a rapid host inflammatory response that controlled infection vs. wild-type mice not expressing GM-CSF in the lungs. This resistance to influenza was abrogated by elimination of alveolar phagocytes, but not by depletion of T cells, B cells or neutrophils. Tg mice had far more alveolar macrophages than wild-type mice and were more resistant to influenza-induced apoptosis. Delivery of intranasal GM-CSF to wild-type mice also conferred influenza resistance. Therefore, GM-CSF confers resistance to influenza by enhancing innate immune mechanisms that depend on alveolar macrophages. Pulmonary delivery of GM-CSF is therefore useful for reducing the significant morbidity and mortality due to influenza virus and is similarly useful in pulmonary infection caused by other infectious viral and bacterial agents. | 07-10-2014 |
| 20140193401 | PERTUSSIS ANTIBODIES AND USES THEREOF - Compositions and methods are provided that are useful to treat respiratory diseases such as whooping cough. Further, compositions and methods of immunizing are provided. | 07-10-2014 |
| 20140191140 | SYSTEMS AND METHODS FOR ALTERING VISUAL ACUITY - Provided are methods, systems, and apparatus for altering a modulation transfer function of an imaging system. The described methods, systems and apparatus can be used to temporarily alter visual acuity of a subject. | 07-10-2014 |
| 20140188901 | EFFICIENTLY IDENTIFYING IMAGES, VIDEOS, SONGS OR DOCUMENTS MOST RELEVANT TO THE USER USING BINARY SEARCH TREES ON ATTRIBUTES FOR GUIDING RELEVANCE FEEDBACK - A method, system and computer program product for efficiently identifying images, videos, audio files or documents relevant to a user using binary search trees in attribute space for guiding relevance feedback. A binary tree is constructed for each relative attribute of interest. A “pivot exemplar” (at a node of the binary tree) is set for each relative attribute's binary tree as corresponding to the database image, video, audio file or document with a median relative attribute value among that subtree's child examples. A pivot exemplar out of the available current pivot exemplars that has the highest expected information gain is selected to be provided to the user. Comparative attribute feedback is then received from the user regarding whether a degree of the attribute in the user's target image, video, audio file or document is more, less or equal with the attribute displayed in the selected pivot exemplar. | 07-03-2014 |
| 20140188863 | EFFICIENTLY IDENTIFYING IMAGES, VIDEOS, SONGS OR DOCUMENTS MOST RELEVANT TO THE USER BASED ON ATTRIBUTE FEEDBACK - A method, system and computer program product for efficiently identifying images, videos, audio files or documents relevant to a user. Using either manual annotations or learned functions, the method predicts the relative strength of an attribute in an image, video, audio file or document from a pool of images, videos, audio files or documents. At query time, the system presents an initial set of reference images, videos, audio files or documents, and the user selects among them to provide relative attribute feedback. Using the resulting constraints in the multi-dimensional attribute space, the relevance function for the pool of images, videos, audio files or documents is updated and the relevance of the pool of images, videos, audio files or documents is re-computed. This procedure iterates using the accumulated constraints until the top-ranked images, videos, audio files or documents are acceptably close to the user's envisioned image, video, audio file or document. | 07-03-2014 |
| 20140183046 | MEMBRANELESS SEAWATER DESALINATION - Disclosed are microfluidic devices and systems for the desalination of water. The devices and systems can include an electrode configured to generate an electric field gradient in proximity to an intersection formed by the divergence of two microfluidic channels from an inlet channel. Under an applied bias and in the presence of a pressure driven flow of saltwater, the electric field gradient can preferentially direct ions in saltwater into one of the diverging microfluidic channels, while desalted water flows into second diverging channel. Also provided are methods of using the devices and systems described herein to decrease the salinity of water. | 07-03-2014 |
| 20140182851 | NOVEL ANIONIC POLYALKOXY GROUP COMPRISING SURFACTANTS ON BASIS OF GUERBET-ALCOHOLS, METHOD OF MANUFACTURE AND USE IN ENHANCED OIL RECOVERY (EOR) APPLICATIONS - Compositions and methods of synthesis of anionic surfactants by alkoxylation of a Guerbet alcohol (GA) having 12 to 36 carbon atoms using butylene oxide, and optionally propylene oxide and/or ethylene oxide followed by the incorporation of a terminal anionic group are described herein. The GA of the present invention is made by a facile and inexpensive method that involves high temperature base catalyzed dimerization of alcohols with 6 to 18 carbon atoms. The large hydrophobe ether surfactants of the present invention find uses in enhanced oil recovery (EOR) applications where it is used for solubilization and mobilization of oil and for environmental cleanup. Further, the hydrophobe alkoxylated GA without anionic terminal group can be used as an ultra-high molecular weight non-ionic surfactant. | 07-03-2014 |
| 20140182742 | ROBOTIC INFUSION MIXER AND TRANSPORTABLE CARTRIDGE - The invention relates to a transportable therapeutic cartridge, a therapeutic agent robotic mixer and a method for providing therapeutic infusion services. The transportable therapeutic cartridge is configured to be used to manually mix therapeutic agents or to be coupled to a therapeutic agent robotic mixer, such that the robotic mixer can access therapeutic agents disposed in the cartridge and automatically mix therapeutic agents. The cartridge, mixer, and method provide therapeutic infusions in a just-in-time fashion, so as to minimize risk to patients and facility staff while maximizing the use and safety of the therapeutics. | 07-03-2014 |
| 20140178297 | Seeds and Markers for Use in Imaging - A contrast marker having a casing and a novel MRI contrast agent comprising metal complexes disposed around, within, or abuting the casing is provided. Such contrast markers may be placed in a strand, with or without a therapy seed, to produce a seeded strand useful for imaging and in connection with brachytherapy. | 06-26-2014 |
| 20140171807 | MEASUREMENT OF NEURAL FUNCTIONALITY USING PHASE SENSITIVE OPTICAL COHERENCE REFLECTOMETRY - Optical methods, devices, and systems for noninvasively detecting transient surface displacements in a neuron are disclosed. Methods, devices, and systems provided may employ a phase-sensitive optical low coherence reflectometer. In addition, surface displacements due to action potential propagation in neural tissues may be detected in some embodiments using back-reflected light. According to some embodiments, exogenous chemicals or reflect ion coatings are not required. Transient neural surface displacement of less then 1 nm in amplitude and 1 ms in duration may be detected and may be generally coincident with action potential arrival to the optical measurement site. The systems and methods may be used for noninvasive detection of various neuropathies such as retinal neuropathies. They may also be useful in detecting the effects of various pharmacological agents. | 06-19-2014 |
| 20140170643 | PARP Substrates and Biomarkers - PARylated proteins are enriched by treating cell lysates comprising PARylated proteins and DNA/RNA with an endonuclease that cleaves the DNA/RNA but not the PAR; and separating the PARylated proteins from the cleaved DNA/RNA. PARylation sites are labeled by eluting PARylated proteins from a PAR-affinity substrate with a nucleophilic amine exchange reactant, wherein the reactant labels PARylation sites of the proteins. Specific binding agents are identified by screening compounds for specific binding to a PARylated protein disclosed herein; and identifying one of the compounds as a specific binder of the protein. Antibodies which specifically bind PARylation sites are also disclosed. | 06-19-2014 |
| 20140161724 | Compositions and Imaging Methods Comprising Detectably Labeled Phosphatidylethanolamine-Binding Peptides - Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are advantageous antibody, immunoconjugate and duramycin-based compositions and combinations that bind and inhibit anionic phospholipids and aminophospholipids, for use in the safe and effective treatment of cancer, viral infections and related diseases. | 06-12-2014 |
| 20140144517 | RAIL PLASMA ACTUATOR FOR HIGH-AUTHORITY FLOW CONTROL - Apparatus and methods for forming and propagating a plurality of plasma armatures along electrodes. In particular embodiments, the electrodes are flush mounted to the surface and the plasma armatures are formed and propagated at a high frequency and velocity. | 05-29-2014 |
| 20140143367 | ROBUSTNESS IN A SCALABLE BLOCK STORAGE SYSTEM - A storage system that accomplishes both robustness and scalability. The storage system includes replicated region servers configured to handle computation involving blocks of data in a region. The storage system further includes storage nodes configured to store the blocks of data in the region, where each of the replicated region servers is associated with a particular storage node of the storage nodes. Each storage node is configured to validate that all of the replicated region servers are unanimous in updating the blocks of data in the region prior to updating the blocks of data in the region. In this manner, the storage system provides end-to-end correctness guarantees for read operations, strict ordering guarantees for write operations, and strong durability and availability guarantees despite a wide range of server failures (including memory corruptions, disk corruptions, etc.) and scales these guarantees to thousands of machines and tens of thousands of disks. | 05-22-2014 |
| 20140138548 | APPARATUS AND METHODS FOR PHOTOSENSOR QUADRANT SHARING - Apparatus and methods comprising a positron emission tomography detector having a first rectangular cross-section crystal block positioned between a first pentagonal cross-section crystal block and a second pentagonal cross-section crystal block. | 05-22-2014 |
| 20140137257 | System, Method and Apparatus for Assessing a Risk of One or More Assets Within an Operational Technology Infrastructure - A system, method and apparatus assesses a risk of one or more assets within an operational technology infrastructure by providing a database containing data relating to the one or more assets, calculating a threat score for the one or more assets using one or more processors communicably coupled to the database, calculating a vulnerability score for the one or more assets using the one or more processors, calculating an impact score for the one or more assets using the one or more processors, and determining the risk of the one or more assets based on the threat score, the vulnerability score and the impact score using the one or more processors. | 05-15-2014 |
| 20140131279 | SIMULTANEOUS REMOVAL OF OIL AND GASES FROM LIQUID SOURCES USING A HOLLOW FIBER MEMBRANE - The present invention includes an apparatus and method for removing oil from a oil-containing liquid comprising oil and gas comprising: a source of oil-containing liquid; and a membrane contactor system in fluid communication with the source of oil-containing liquid, the membrane contactor system comprising one or more membrane contactors having a first and a second surface, wherein the first surface coalesces oil and removes gas from the oil-containing liquid, and the oil and gas are collected on the second surface from the oil-containing liquid. | 05-15-2014 |
| 20140127285 | Composition and Method for Making Oligo-Benzamide Compounds - The present invention includes compound compositions and methods of making compounds that include an oligo-benzamide compound having at least two optionally substituted benzamides. | 05-08-2014 |
| 20140126808 | RECURSIVE CONDITIONAL MEANS IMAGE DENOISING - Methods and composition for denoising digital camera images are provided herein. The method is based on directly measuring the local statistical structure of natural images in a large training set that has been corrupted with noise mimicking digital camera noise. The measured statistics are conditional means of the ground truth pixel value given a local context of input pixels. Each conditional mean is the Bayes optimal (minimum mean squared error) estimate given the specific local context. The conditional means are measured and applied recursively (e.g., the second conditional mean is measured after denoising with the first conditional mean). Each local context vector consists of only three variables, and hence the conditional means can be measured directly without prior assumptions about the underlying probability distributions, and they can be stored in fixed lookup tables. | 05-08-2014 |
| 20140123342 | Regulation of Stomatal Apertures by Apyrases and Extracellular Nucleotides - The role of extracellular nucleotides and apyrase enzymes in the guard cells that border stomata in regulating stomatal aperture and the plant's resistance to drought and pathogens is disclosed herein. Expression of apyrases APY1 and APY2, in guard cell protoplasts is strongly correlated with cell growth, cell secretory activity and with conditions that favor stomatal opening. Both short-term inhibition of ectoapyrase activity and long-term suppression of APY1 and APY2 transcript levels significantly disrupt normal stomatal behavior in light. Furthermore, two punnoceptor inhibitors in mammals, pyridoxalphosphate-6-azo-phenyl-2′,4′-disulphonic acid (PPADS) and Reactive Blue 2, block ATPS- and ADPβS-induced opening and closing, and also partially block the ability of abscisic acid (ABA) to induce stomatal closure, and light-induced stomatal opening. Treatment of epidermal peels with ATPyS induces increased levels of nitric oxide and reactive oxygen species, and genetically suppressing the synthesis of these agents blocks the effects of nucleotides on stomatal aperture. | 05-01-2014 |
| 20140121820 | Systems And Methods For Manufacturing Optimization - In one embodiment, a manufacturing process is optimized by enabling a user to specify a product to be manufactured, enabling the user to specify a manufacturing system for manufacturing the product, enabling the user to select parameters for the product and the manufacturing system, and automatically calculating manufacturing metrics for the manufacturing process based upon the user-specified models and user selections. | 05-01-2014 |
| 20140121803 | Modular And Reconfigurable Manufacturing Systems - In one embodiment, a manufacturing system includes multiple manipulation modules each including means for mechanically and electrically connecting the module to another component in the system and an end effector including means for mechanically and electrically connecting the end effector to another component in the system, wherein the modules and end effector can be mechanically and electrically connected in multiple ways to alter the configuration of the system and the manufacturing tasks that the system can perform. | 05-01-2014 |
| 20140121514 | METHOD OF MEASURING PROPULSION IN LYMPHATIC STRUCTURES - Novel methods and imaging agents for functional imaging of lymph structures are disclosed herein. Embodiments of the methods utilize highly sensitive optical imaging and fluorescent spectroscopy techniques to track or monitor packets of organic dye flowing in one or more lymphatic structures. The packets of organic dye may be tracked to provide quantitative information regarding lymph propulsion and function. In particular, lymph flow velocity and pulse frequency may be determined using the disclosed methods. | 05-01-2014 |
| 20140120139 | METHODS FOR INDUCING AN IMMUNE RESPONSE VIA BUCCAL AND/OR SUBLINGUAL ADMINISTRATION OF A VACCINE - Vaccine compositions that may be administered to a subject via the buccal and/or sublingual mucosa are provided. Methods for administration and preparation of such vaccine compositions are also provided. | 05-01-2014 |
| 20140114389 | PLAIN WOVEN STENTS - Self-expandable, woven intravascular devices for use as stents (both straight and tapered), filters (both temporary and permanent) and occluders for insertion and implantation into a variety of anatomical structures. The devices may be formed from shape memory metals such as nitinol. The devices may also be formed from biodegradable materials. Delivery systems for the devices include two hollow tubes that operate coaxially. A device is secured to the tubes prior to the implantation and delivery of the device by securing one end of the device to the outside of the inner tube and by securing the other end of the device to the outside of the outer tube. The stents may be partially or completely covered by graft materials, but may also be bare. The devices may be formed from a single wire. The devices may be formed by either hand or machine weaving. The devices may be created by bending shape memory wires around tabs projecting from a template, and weaving the ends of the wires to create the body of the device such that the wires cross each other to form a plurality of angles, at least one of the angles being obtuse. The value of the obtuse angle may be increased by axially compressing the body. | 04-24-2014 |
| 20140113290 | ABERRANT METHYLATION OF C6ORF150 DNA SEQUENCES IN HUMAN COLORECTAL CANCER - This application describes methods and compositions for detecting and treating C6Orf150-associated neoplasia. Differential methylation of the C6Orf150 nucleotide sequences has been observed in C6Orf150-associated neoplasia such as colon neoplasia. | 04-24-2014 |
| 20140100494 | SMART GAIT REHABILITATION SYSTEM FOR AUTOMATED DIAGNOSIS AND THERAPY OF NEUROLOGIC IMPAIRMENT - The present invention describes a Smart Gait Rehabilitation System (SGRS). The present invention is capable of performing a quantitative analysis of human movements based on the simultaneous measurement of within-subject stride-to-stride changes in gait using accelerometers, gyroscopes, goniometers, and electromyography (EMG). The system described in the present invention is based on step-training that incorporates sensory feedback, provide feedback about kinematics and torques, and proceeds at walking speeds typical of overground ambulation. | 04-10-2014 |
| 20140099324 | HERV-K ANTIGENS, ANTIBODIES, AND METHODS - Methods and compositions for cancer diagnostics and therapy are provided. More particular, methods and compositions for detecting, preventing, and treating HERV-K | 04-10-2014 |
| 20140098373 | POLARIZATION-SENSITIVE SPECTRAL INTERFEROMETRY - A polarization sensitive spectral interferometer apparatus and method for analyzing a sample by optical energy reflected from the sample. The polarization sensitive spectral interferometer apparatus and method determines polarization properties of the sample by optical energy reflected from the sample. | 04-10-2014 |
| 20140096967 | SALT-TOLERANT ANIONIC SURFACTANT COMPOSITIONS FOR ENHANCED OIL RECOVERY (EOR) APPLICATIONS - The present invention includes compositions and methods for using an anionic surfactant composition for treating a hydrocarbon-bearing formation or a reservoir, of formula (I): | 04-10-2014 |
| 20140091410 | Method and Apparatus for Fabricating Piezoresistive Polysilicon by Low-Temperature Metal Induced Crystallization - The present invention provides a method and apparatus for fabricating piezoresistive polysilicon on a substrate by low-temperature metal induced crystallization by: (1) providing the substrate having a passivation layer; (2) performing, at or near room temperature in a chamber without breaking a vacuum or near-vacuum within the chamber, the steps of: (a) creating a metal layer on the passivation layer, and (b) creating an amorphous silicon layer on the metal layer, wherein the metal layer and the amorphous silicon layer have approximately the same thickness; (3) annealing the substrate, the passivation layer, the metal layer and the amorphous silicon layer at a temperature equal to or less than 600° C. and a period of time equal to or less than three hours to form a doped polysilicon layer below a residual metal layer; and (4) removing the residual metal layer to expose the doped polysilicon layer. | 04-03-2014 |
| 20140090173 | INTEGRATED PATIENT BED SYSTEM - The present invention includes an integrated system and methods for patient treatment, the system includes a hospital bed; a plurality of patient diagnostic and treatment devices connected to a network, wherein each of the devices can communicate to a network and exchange information with the network about the care of a patient; and a processor accessible adjacent to the bed and connected to the network to integrate information obtained from the devices through the network with one or more additional sources of information databases, wherein the processor can communicate to one or more patient treatment devices either directly or via the network and the processor directs the one or more patient treatment devices to change the treatment of the patient. | 04-03-2014 |
| 20140086866 | Methods For Endoscopic Mucosal Resection And Endoscopic Submucosal Dissection - In one aspect, methods for separating biological tissue are described herein. In some embodiments, a method for separating tissue comprises providing a first composition comprising a polymerizable material, providing a second composition comprising a polymerization initiator, disposing the first composition at a first site beneath a first tissue layer, disposing the second composition at the first site, polymerizing the polymerizable material at the first site, and separating the first tissue layer from a second tissue layer. | 03-27-2014 |
| 20140083970 | FORWARD-IMAGING OPTICAL COHERENCE TOMOGRAPHY (OCT) SYSTEMS AND PROBES - Provided are forward-imaging optical coherence tomography (OCT) systems and probes. | 03-27-2014 |
| 20140080638 | SYSTEMS AND METHODS FOR PROVIDING TRAINING AND INSTRUCTION TO A FOOTBALL KICKER - In one embodiment, kicking training is provided to a kicker in real time by collecting data while the kicker kicks a ball toward a display screen, determining the trajectory of the ball from the collected data, and displaying to the kicker on the display screen a simulation of the flight of the ball within a virtual world. | 03-20-2014 |
| 20140080019 | MONOCLINIC Sr1-xAxSi1-yGeyO3-0.5x, WHEREIN A IS K or Na, OXIDE ION CONDUCTOR - The disclosure provides a material with the general formula Sr | 03-20-2014 |
| 20140075591 | ENGINEERING LIPIDS IN VEGETATIVE TISSUES OF PLANTS - The present invention discloses gene targets and methods for the genetic control of lipid accumulation in vegetative (non-seed) portions of plants. Enhanced lipid, e.g. triacylglycerol (TAG), accumulation in vegetative portions of plants may be obtained by down-regulation of activity of At4g24160 or a homolog thereof. Plants, plant parts, seeds comprising down-regulated AT4G24160 activity, or activity of a homolog thereof, are also provided, as well as products prepared therefrom. | 03-13-2014 |
| 20140066423 | POLYCYCLIC BETA LACTAM DERIVATIVES FOR THE TREATMENT OF CANCER - Provided herein are polycyclic β-lactam compounds, compositions thereof and methods for the treatment and prevention of diseases such as cancer, including pancreatic cancer and pancreatic cancers resistant to mainline chemotherapeutic agents. | 03-06-2014 |
| 20140066382 | Autophagy-Inducing Peptide - An autophagy-inducing compound comprises an autophagy-inducing peptide comprising beclin-1 residues 269-283 and a heterologous moiety that promotes therapeutic stability or delivery of the compound. The compound may be used to induce autophagy and in assays with beclin-1 binding partners. | 03-06-2014 |
| 20140065148 | TREATMENT METHODS USING ANTIBODIES TO AMINOPHOSPHOLIPIDS - Disclosed are the surprising discoveries that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are stable and specific markers accessible on the luminal surface of tumor blood vessels, and that the administration of an anti-aminophospholipid antibody alone is sufficient to induce thrombosis, tumor necrosis and tumor regression in vivo. This invention therefore provides anti-aminophospholipid antibody-based methods and compositions for use in the specific destruction of tumor blood vessels and in the treatment of solid tumors. Although various antibody conjugates and combinations are thus provided, the use of naked, or unconjugated, anti-phosphatidylserine antibodies is a particularly important aspect of the invention, due to simplicity and effectiveness of the approach. | 03-06-2014 |
| 20140065121 | BLOOD PLASMA BASED HYDROGELS FOR TISSUE REGENERATION AND WOUND HEALING APPLICATIONS - The present disclosure generally relates to tissue engineering and wound healing. More particularly, the present disclosure relates to the modification of plasma with a stability conferring agent to create a hydrogel for use in regenerative medicine and other tissue engineering applications. | 03-06-2014 |
| 20140065106 | Blood Plasma Based Hydrogels for Tissue Regeneration and Wound Healing Applications - The present disclosure generally relates to tissue engineering and wound healing. More particularly, the present disclosure relates to the modification of plasma with a stability conferring agent to create a hydrogel for use in regenerative medicine and other tissue engineering applications. | 03-06-2014 |
| 20140060193 | DEVICES, SYSTEMS, AND METHODS FOR NON-DESTRUCTIVE TESTING OF MATERIALS AND STRUCTURES - Provided are devices, systems, and methods for the testing of materials and structures. For example, the devices, systems, and methods are optionally used for the non-destructive testing of a material or structure. Furthermore, the devices, systems, and methods may optionally use a high-amplitude, air-coupled acoustic source for non-destructive testing of materials and structures. | 03-06-2014 |
| 20140057797 | Methods for Detecting an increased risk for coronary heart disease - The invention relates generally to an allele on human chromosome 9 associated with increased risk for coronary heart disease and the use or detection of such an allele in determining whether a human has an increased risk for coronary heart disease. In one aspect, the invention relates to methods for detecting a predisposition or propensity or susceptibility for coronary heart disease in a human, comprising detecting the presence of an allele on human chromosome 9 that is associated with an increased risk for coronary heart disease in a human. Disclosed are methods and compositions for determining whether a person carries an allele associated with increased risk for coronary atherosclerosis by determining whether the person has an RA-CHR9 allele, such as by determining whether the person has an RA-CHR9 allele-associated single nucleotide polymorphism (SNP). The invention also relates to kits for detecting the presence of an allele on chromosome 9 associated with an increased risk for coronary heart disease. | 02-27-2014 |
| 20140053780 | Plasma Polymerization for Encapsulating Particles - The present invention includes systems, methods and compositions for the encapsulation of particles. In one form, the system comprises one or more particles, a rotatable reaction chamber in a plasma enhanced chemical reactor to accept one or more particles, and at least one carbonaceous compound to be used in the rotatable reaction chamber, wherein the carbonaceous compound is polymerized onto a surface of one or more particles forming a polymer film encapsulating one or more particles. Using systems, methods, and compositions of the present invention, any particle encapsulated with a degradable or nondegradable polymer film may be introduced and/or released into an environment. The polymer film as well as introduction of encapsulated particles and release therefrom into an environment are controlled by the present invention. | 02-27-2014 |
| 20140053650 | ACOUSTIC SENSOR - A method of designing and manufacturing an acoustic sensor having a high degree of directivity is disclosed. The sensor includes a rotatable plate that is attached to a substrate with mounts. In one aspect the mounts are freely rotatable and the torque on the plate is measured using detectors disposed on springs that provide a resistance to rotation of the plate. In another aspect the plate is mounted to the substrate with mounts that torsionally deform during rotation of the plate. These detectors measure the torque on the plate according to the torsional deformation of the mounts. Methods of improving the signal to noise ratio of acoustic sensors having multiple detectors are also disclosed. | 02-27-2014 |
| 20140044745 | Influenza A Virus Vaccines and Inhibitors - The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development. | 02-13-2014 |
| 20140039031 | PHARMACEUTICAL FORMULATIONS OF ACETYL-11-KETO-B-BOSWELLIC ACID, DIINDOLYLMETHANE, AND CURCUMIN FOR PHARMACEUTICAL APPLICATIONS - The present disclosure is directed to compositions and methods for formulating a pharmaceutical dosage form by forming a composition comprising acetyl-11-keto-β-boswellic acid, diindolylmethane, or curcumin with one or more pharmaceutically acceptable excipients for enhanced solubility to increase bioavailability and improve therapeutic efficacy. The composition can be processed by thermo-kinetic compounding along with conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding. | 02-06-2014 |
| 20140038837 | BIOMARKERS FOR THE DETECTION OF EARLY STAGE OVARIAN CANCER - The present invention provides methods and compositions for detecting early stage ovarian cancer in a patient. Also, methods for evaluating the ovarian cancer state of a patient are described herein. These methods involve the detection, analysis, and classification of biomarkers in biological samples. | 02-06-2014 |
| 20140031366 | AZOLE PHARMACEUTICAL FORMULATIONS FOR PARENTERAL ADMINISTRATION AND METHODS FOR PREPARING AND USING THE SAME AS TREATMENT OF DISEASES SENSITIVE TO AZOLE COMPOUNDS - A parenteral azole composition comprises a first solvent, made of benzyl alcohol and/or an acidified alcohol such as ethanol, and a lipophilic component such as PEG400, and the azole, or triazole, such as itraconazole or posaconazole dissolved in this first composite solvent vehicle that is essentially free of surfactants, particularly non-ionic surfactants, and has low levels of water, preferably less than 5% water. The composition may be further diluted with an infusion fluid, such as normal saline or 5% or 10% dextrose in water, before infusion into an immunocompromized mammal, preferably a human. The composition is useful for the treatment and suppression of infections caused by microbes such as yeast and molds that are sensitive to azoles, but it may be extended to dissolve other pharmaceutically active agents that can be used to treat other types of infectious diseases or other ailments, such as malignant and autoimmune diseases. | 01-30-2014 |
| 20140030340 | PREPARATION OF DRUG PARTICLES USING EVAPORATION PRECIPITATION INTO AQUEOUS SOLUTIONS - A method for preparing poorly water soluble drug particles is disclosed. The method comprises dissolving a drug in at least one organic solvent to form a drug/organic mixture, spraying the drug/organic mixture into an aqueous solution and concurrently evaporating the organic solvent in the presence of the aqueous solution to form an aqueous dispersion of the drug particles. The resulting drug particles are in the nanometer to micrometer size range and show enhanced dissolution rates and reduced crystallinity when compared to the unprocessed drug. The present invention additionally contemplates products and processes for new drug formulations of insoluble drug particles having high dissolution rates and extremely high drug-to-excipient ratios. | 01-30-2014 |
| 20140030260 | METHODS AND COMPOSITIONS TO ELIMINATE CHRONIC LYMPHOCYTIC LEUKEMIA AND OTHER HEMATOLOGIC MALIGNANT CELLS IN STROMAL MICROENVIRONMENT FOR CANCER THERAPY - The present invention regards compositions and methods for treating chronic lymphocytic leukemia in the in vivo tissue environment using selenium-containing compositions. In particular aspects, a selenium-comprising compound is administered to an individual wherein the CLL cells are in a stromal cell environment, wherein stromal factors modulate the selenium comprising compound to enhance its activity. | 01-30-2014 |
| 20140027295 | Amorphous IrOX Film pH Sensor - The present invention provides a pH sensing apparatus that includes a flexible polymer substrate, one or more amorphous iridium oxide film sensor electrodes disposed on the flexible polymer substrate, and a reference electrode corresponding to each amorphous iridium oxide film sensor electrode. Each reference electrode is disposed on the flexible polymer substrate in close proximity to the corresponding amorphous iridium oxide film sensor electrode. The amorphous iridium oxide film sensor electrodes provide a potential in reference to the reference electrodes that varies according to a pH of a substance contacting the amorphous iridium oxide film sensor electrodes and the reference electrodes. | 01-30-2014 |
| 20140024617 | TREATMENT OF CANCER WITH COMPLEX ORGANIC-INORGANIC PIGMENT COMPOSITIONS - The present invention includes compositions and methods for treating disorders of the skin or mucosa resulting from cancer therapies comprising: identifying a patient receiving cancer treatment; and administering to said patient an effective dose of a treated organic/inorganic complex material with an organic dye molecule or derivative thereof, in a pharmaceutically acceptable carrier. | 01-23-2014 |
| 20140024540 | LIGAND IDENTIFICATION - The present disclosure provides new and improved phage display methodologies. Among other things, the present invention provides methodologies that do not utilize bacterial amplification of phage. Alternatively or additionally, the present invention provides phage display systems that rapidly identify ligands. Alternatively or additionally, the present invention provides phage display methodologies for use in human subjects. Alternatively or additionally, the present invention provides phage display systems that allow detection and/or characterization of low abundance ligands. | 01-23-2014 |
| 20140021167 | Large Area Patterning of Nano-Sized Shapes - Methods for creating nano-shaped patterns are described. This approach may be used to directly pattern substrates and/or create imprint lithography molds that may be subsequently used to directly replicate nano-shaped patterns into other substrates in a high throughput process. | 01-23-2014 |
| 20140011955 | Covalently Functionalized Particles for Synthesis of New Composite Materials - The present invention includes compositions and methods for synthesis of composite materials involving gas phase plasma polymerization to covalently plasma graft an organic molecule onto inorganic particles; covalently binding an organic monomer to the functionalized inorganic particles; and, polymerizing the organic monomers into inorganic/organic hybrid polymer composite materials. | 01-09-2014 |
