BIOO Scientific Corporation. Patent applications |
Patent application number | Title | Published |
20140342442 | TOUCHSCREEN DEVICE AND METHODS FOR USE IN DETECTION OF MICRORNA - A method and sensor for detecting the presence of specific target nucleic acids uses a biosensor comprising an array of single stranded probe oligonucleotides, wherein one end of each probe oligonucleotide is linked to a label and the other end of each probe oligonucleotide is attached to an electrode of a solid support. The method includes determining the capacitance at one or more of the electrodes, where a change in the capacitance of the one or more electrodes indicates the presence of target nucleic acid complementary to the single stranded oligonucleotide probe. | 11-20-2014 |
20140295418 | METHODS AND COMPOSITIONS FOR IMPROVING REMOVAL OF RIBOSOMAL RNA FROM BIOLOGICAL SAMPLES - The invention generally relates to compositions for maximizing capture of affinity-labeled molecules on solid supports. The disclosed methods and compositions were developed to maximize depletion of ribosomal RNA from total RNA samples, which is useful to improve the quality of RNA preparations used for applications such as massively parallel sequencing. The RNA depletion method is based on using long affinity-labeled RNA molecules that are complementary to all or part of the target ribosomal RNAs, as subtractive hybridization probes. | 10-02-2014 |
20140170649 | LATERAL FLOW DETECTION OF TARGET SEQUENCES - Provided is a sensitive method to specifically detect nucleic acid sequences using a combination of DNA replication based signal amplification (e.g., PCR) and lateral flow analyte detection. The disclosed method uses a dual-labeled DNA probe complementary to a region of the target DNA sequence. Cleavage of the probe, caused by the presence of the amplified DNA target, is detected using lateral flow methods. | 06-19-2014 |
20140128292 | METHODS FOR IMPROVING LIGATION STEPS TO MINIMIZE BIAS DURING PRODUCTION OF LIBRARIES FOR MASSIVELY PARALLEL SEQUENCING - Described herein is a thermostable enzyme capable of efficient ligation of two oligomers at high temperature. The embodiments herein have led to the development of an optimized ligation step used in library preparation for sequencing reactions. | 05-08-2014 |
20140099656 | RAPID DETECTION OF HISTAMINE IN FOOD AND BEVERAGES - Described herein is a rapid, semi-quantitative sampling device which may rapidly detect histamine in food, beverage and feed samples. The device uses an enzyme (impregnated in a sampling pad) to specifically convert histamine present in samples to a visual colorimetric signal. The color change of the pad is proportional to the amount of histamine present in the sample. | 04-10-2014 |
20140046035 | IMPROVED PRODUCTION OF ANTI-PEPTIDE ANTIBODIES - Anti-peptide antibodies (APAs) are extremely important tools for biomedical research. Many important techniques, such as immunoblots, ELISA immunoassays, immunocytochemistry, and protein microarrays are intrinsically linked to APA function and completely dependent on APA quality. Unfortunately, not all commercially-available APAs have good antigen binding characteristics; as a result, researchers are often unable to perform high quality protein analysis experiments. This disclosure describes a new method for the scalable production of polyclonal APAs using recombinant antigens. These recombinant peptide antigens have several advantages over traditional peptide antigens which improve the ease and speed of antibody production. The recombinant antigens can be scalably produced and purified much faster than traditional synthetic peptide-conjugates. These recombinant antigen-carriers are designed to specifically aggregate in vivo after administration into the host; this aggregation greatly enhances immunogenicity and may eliminate the need for the use of chemical adjuvants which cause physical irritation and discomfort to the host. | 02-13-2014 |
20090306194 | NOVEL COMPOSITIONS FOR THE IN VIVO DELIVERY OF RNAI AGENTS - This application describes emulsion formulations containing neutral phospholipids for delivering RNAi, anti-miRNA, or aptamer agents in vivo. The application also relates to methods of making the formulations, and uses of the formulations as delivery agents. | 12-10-2009 |