| BAYER HEALTHCARE LLC Patent applications |
| Patent application number | Title | Published |
|---|
| 20160115219 | FACTOR VIII GLYCOFORMS - The invention concerns glycosylated proteins having human factor VIII activity. In a preferred embodiment, the protein is glycosylated with oligosaccharides that include an alpha-(2,6)-linked sialic acid and a bisecting GlcNAc linked to a core beta-mannose. | 04-28-2016 |
| 20160051633 | METHODS OF TREATING HEMOPHILIA IN PATIENTS HAVING DEVELOPED INHIBITORY ANTIBODIES - This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties. | 02-25-2016 |
| 20160031968 | VARIANT FACTOR VIII POLYPEPTIDES AND METHODS OF THEIR PRODUCTION AND USE - This disclosure relates to variant Factor VIII polypeptides comprising an amino acid substitution at one or more positions within one or both of the thrombin cleavage site and the activation loop. In certain embodiments, the variant Factor VIII polypeptide comprises one or more amino acid substitutions within both the thrombin cleavage site and the activation loop. In further embodiments, the variant factor VIII polypeptide further comprises one or more amino acid substitutions within the A1-A2 domain interface and the A2-A3 domain interface. The present disclosure further relates to methods of producing and/or using such variant Factor VIII polypeptides; nucleic acids encoding the polypeptides; vectors and/or recombinant cells, tissues, or organisms containing such nucleic acids; and kits and pharmaceutical compositions containing such polypeptides and/or nucleic acids. | 02-04-2016 |
| 20160030524 | RECOMBINANT FACTOR VIII FORMULATIONS - Provided are liquid and lyophilized recombinant Factor VIII formulations, including formulations for polymer-conjugated FVIII such as PEGylated Factor VIII. | 02-04-2016 |
| 20160015697 | ARYL UREAS WITH ANGIOGENISIS INHIBITING ACTIVITY - This invention relates to methods of using aryl ureas to treat diseases mediated by the VEGF induced signal transduction pathway characterized by abnormal angiogenesis or hyperpermeability processes. | 01-21-2016 |
| 20150366584 | TIP PROTECTOR SLEEVE - Assemblies and methods of inserting a delivery catheter assembly into a working channel are disclosed. In accordance with some embodiments, a delivery catheter assembly is disclosed in which a tip protector sleeve is locked onto an elongated catheter sheath and slideable over a length of the elongated catheter sheath between a proximal-stop position and a distal-stop position along the elongated catheter sheath. | 12-24-2015 |
| 20150344863 | SHORT-ACTING FACTOR VII POLYPEPTIDES - Short-acting Factor VII peptides are disclosed. A shortened half-life is desirable for treatment of acute bleeding and similar disorders. Modification of the sialylation and/or glycosylation of Factor VII and variants thereof produced peptides useful in treating conditions of acute bleeding. | 12-03-2015 |
| 20150328145 | TOPICAL OPHTHALMOLOGICAL PHARMACEUTICAL COMPOSITION CONTAINING REGORAFENIB - The present invention relates to topical ophthalmological pharmaceutical compositions containing regorafenib, a hydrate, solvate or pharmaceutically acceptable salt thereof or a polymorph thereof but without hydrophobic silica and its process of preparation and its use for treating ophthalmological disorders. | 11-19-2015 |
| 20150322164 | HUMANIZED MONOCLONAL ANTIBODIES AGAINST ACTIVATED PROTEIN C AND USES THEREOF - Provided are humanized antibodies that selectively bind to and inhibit activated protein C without binding to or inhibiting unactivated protein C. Methods of treatment employing these antibodies are described herein. | 11-12-2015 |
| 20150307625 | MONOCLONAL ANTIBODIES AGAINST ACTIVATED PROTEIN C (aPC) - Provided herein are antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human activated Protein C (aPC) with minimal binding to its zymogen Protein C (PC). Moreover, these aPC binding proteins could potentially block the anti-coagulant activity of aPC to induce coagulation. Therapeutic uses of these binders are described herein as are methods of panning and screening specific antibodies. | 10-29-2015 |
| 20150299638 | METHODS AND SYSTEMS FOR OPTIMIZING PERFUSION CELL CULTURE SYSTEM - Methods and perfusion culture systems are disclosed. The systems and methods relate to decreasing the starting perfusion rate, resulting in increased residence time of the cells in the bioreactor and the cell retention device, and/or concomitantly increasing the starting bioreactor volume or decreasing the starting cell retention device volume, or both. Other method embodiments include increasing the concentrations of individual components of the tissue culture fluid, and adding a stabilizer of the degradation of the recombinant protein. | 10-22-2015 |
| 20150224052 | PROCESS FOR MANUFACTURING CHEWABLE DOSAGE FORMS FOR DRUG DELIVERY AND PRODUCTS THEREOF - A palatable, edible soft chewable medication vehicle for delivery of a pharmaceutically acceptable active ingredient, such as a drug, to an animal or human subject. The edible soft chews contain only food grade or better inactive ingredients, and preferably do not contain ingredients of animal origin. Processes for manufacturing the edible soft chews do not require the use of heat or the addition of water during mixing of active and inactive ingredients, provide stable concentrations of the active ingredient, and produce chews of consistent weight and texture. | 08-13-2015 |
| 20150174096 | TOPICAL OPHTHALMOLOGICAL PHARMACEUTICAL COMPOSITION CONTAINING SUNITINIB - The present invention relates to topical ophthalmological pharmaceutical compositions containing sunitinib, a hydrate, solvate or pharmaceutically acceptable salt thereof or a polymorph thereof and its process of preparation and its use for treating ophthalmological disorders. | 06-25-2015 |
| 20150144484 | REPLACEABLE MULTISTRIP CARTRIDGE AND BIOSENSOR METER - A blood glucose monitor includes a can, a replaceable sensor cartridge that includes a frame, an upper spring disposed between the frame and the can, a case for housing the can and sealing the frame, a lower spring disposed between the can and the case, and a meter housing for sealing an upper portion of the frame. The can is capable of accepting the replaceable sensor cartridge. The frame of the removable cartridge has at least at least two walls defining a chamber for accepting a plurality of biosensors, and a bottom portion defining an opening and at least one sealing flange. The frame can further include a desiccant material capable of reducing humidity within the frame. The frame may be dimensioned such that an interference fit constrains the plurality of biosensors prior to inserting the frame within a blood glucose monitor. | 05-28-2015 |
| 20150141448 | Topical Ophthalmological Pharmaceutical Composition containing Pazopanib - The present invention relates to topical ophthalmological pharmaceutical compositions containing pazopanib, a hydrate, solvate or pharmaceutically acceptable salt thereof or a polymorph thereof and its process of preparation and its use for treating ophthalmological disorders. | 05-21-2015 |
| 20150096902 | Identifying Ionizable Species with Voltammetric Duty Cycles - A sensor system including devices and methods for determining the concentration of an analyte in a sample is described. Input signals including amperometric and voltammetric duty cycles of excitations and relaxations may provide a shorter analysis time and/or improve the accuracy and/or precision of the analysis. The disclosed system may reduce analysis errors, thus improving measurement performance, by adjusting the potential and/or scan rate in response to output currents obtained from voltammetric scans. The disclosed system also may determine the concentration of more than one ionizable species in the sample by adjusting the potential and/or scan rate in response to output currents obtained from voltammetric scans. The multiple, determined concentrations may be used to determine the concentration of multiple analytes or to correct the concentration determined for an analyte, thus improving the measurement performance of the system. | 04-09-2015 |
| 20150083591 | Voltammetric Systems for Assaying Biological Analytes - The present invention relates to systems, methods, and devices for determining the concentration of an analyte in a sample. The use of linear, cyclic, or acyclic voltammetric scans and/or semi-integral, derivative, or semi-derivative data treatment may provide for increased accuracy when determining the concentration of an analyte in a sample. Hematocrit compensation in combination with the data treatments may reduce the hematocrit effect with regard to a glucose analysis in whole blood. In another aspect, fast scan rates may reduce the hematocrit effect. | 03-26-2015 |
| 20150034498 | Concentration Determination in a Diffusion Barrier Layer - The present invention relates to improved electrochemical biosensor strips and methods for determining the concentration of an analyte in a sample. By selectively measuring a measurable species residing in a diffusion barrier layer, to the substantial exclusion of the measurable species residing exterior to the diffusion barrier layer, measurement errors introduced by sample constituents, such as red blood cells, and manufacturing variances may be reduced. | 02-05-2015 |
| 20150018393 | TREATMENT OF CANCERS WITH ACQUIRED RESISTANCE TO KIT INHIBITORS - The present invention provides compositions and methods for treating cancers which have acquired resistance to a KIT inhibitor by administering effective amounts of DAST. | 01-15-2015 |
| 20140363419 | SHORT-ACTING FACTOR VII POLYPEPTIDES - Short-acting Factor VII peptides are disclosed. A shortened half-life is desirable for treatment of acute bleeding and similar disorders. Modification of the sialylation and/or glycosylation of Factor VII and variants thereof produced peptides useful in treating conditions of acute bleeding. | 12-11-2014 |
| 20140336210 | ARYL UREA COMPOUNDS IN COMBINATION WITH OTHER CYTOSTATIC OR CYTOTOXIC AGENTS FOR TREATING HUMAN CANCERS - This invention relates to aryl urea compounds in combination with cytotoxic or cytostatic agents for use in treating raf kinase mediated diseases such as cancer. | 11-13-2014 |
| 20140329866 | OMEGA-CARBOXYARL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS - This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy. | 11-06-2014 |
| 20140314950 | Method Of Making An Electrochemical Sensor Strip - A method of making an electrochemical sensor strip that includes: depositing a first electrode on a base; depositing a second electrode on the base; applying a first layer onto the first electrode; and applying a second layer onto the second electrode. The first layer includes an oxidoreductase and a mediator. The second layer includes a soluble redox species. | 10-23-2014 |
| 20140305808 | Methods of Determining Analyte Concentration Having Enhanced Stability and Hematocrit Performance - The present invention relates to methods of determining the concentration of an analyte in a sample or improving the performance of a concentration determination. The electrochemical sensor strips may include at most 8 μg/mm | 10-16-2014 |
| 20140295571 | METHOD AND ASSEMBLY FOR DETERMINING THE TEMPERATURE OF A TEST SENSOR - An assembly determines an analyte concentration in a sample of body fluid. The assembly includes a test sensor having a fluid-receiving area for receiving a sample of body fluid, where the fluid-receiving area contains a reagent that produces a measurable reaction with an analyte in the sample. The assembly also includes a meter having a port or opening configured to receive the test sensor; a measurement system configured to determine a measurement of the reaction between the reagent and the analyte; and a temperature-measuring system configured to determine a measurement of the test-sensor temperature when the test sensor is received into the opening. The meter determines a concentration of the analyte in the sample according to the measurement of the reaction and the measurement of the test-sensor temperature. | 10-02-2014 |
| 20140294832 | MONOCLONAL ANTIBODIES AGAINST TISSUE FACTOR PATHWAY INHIBITOR (TFPI) - Isolated monoclonal antibodies that bind to specific epitopes of human tissue factor pathway inhibitor (TFPI) and the isolated nucleic acid molecules encoding them are provided. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided. | 10-02-2014 |
| 20140276221 | LANCING DEVICE - A lancing device having a domed structure that can be depressed by application of a force by a user's finger so as to expose the tip of a needle. The domed structure is configured to move from a non-depressed state to a depressed state in a manner that allows for the piercing the users finger. The domed structure may then recoil to its original, non-depressed position upon the user ceasing to apply the force. | 09-18-2014 |
| 20140274902 | RECOMBINANT FVIII FORMULATIONS - Provided are liquid and lyophilized rFVIII formulations, including full-length rFVIII (FL-rFVIII) formulations, B-domain deleted rFVIII (BDD-rFVIII) formulations, and BDD-rFVIII mutant (BDD-rVIII mutant) formulations. Also provided are liquid and lyophilized PEGylated rFVIII (PEG-rFVIII) formulations, including PEGylated full-length rFVIII (PEG-FL-rFVIII) formulations, PEGylated B-domain deleted rFVIII (PEG-BDD-rFVIII) formulations, and PEGylated BDD-rFVIII mutant (PEG-BDD-rFVIII mutant) formulations. | 09-18-2014 |
| 20140273041 | BOTTLED GLUCOSE SENSOR WITH NO HANDLING - A device and system for automatic handling of a sensor strip by a part of meter includes a sensor strip having a first section, a second section, and an intermediate section. The sensor strip includes at least a first opening about a first end thereof and a second opening about a second end thereof. A meter part includes a pair of pivoting catches configured to engage and grasp a sensor strip from a container containing a plurality of sensor strips. The sensor strip may thus be removed from a container for testing without need for manual handling of the strip by a user. | 09-18-2014 |
| 20140271661 | MONOCLONAL ANTIBODIES AGAINST ANTITHROMBIN BETA - This patent document relates to antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human antithrombin β complexed with heparin and/or heparin-like structure (ATβH). These ATβH binding proteins can block the anti-coagulant activity of ATβ to induce coagulation. Therapeutic uses of these antibodies and binders are described herein as are methods of panning and screening specific antibodies. | 09-18-2014 |
| 20140271660 | MONOCLONAL ANTIBODIES AGAINST ANTITHROMBIN BETA - This patent document relates to antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human antithrombin β complexed with heparin and/or heparin-like structure (ATβH). These ATβH binding proteins can block the anti-coagulant activity of ATβ to induce coagulation. Therapeutic uses of these antibodies and binders are described herein as are methods of panning and screening specific antibodies. | 09-18-2014 |
| 20140271659 | ANTI-PROLACTIN RECEPTOR ANTIBODY FORMULATIONS - Provided are a wide concentration range, especially high concentration anti-prolactin receptor antibody formulations that are substantially isosmotic and of low viscosity. | 09-18-2014 |
| 20140268455 | REVERSE BATTERY PROTECTION FOR BATTERY-POWERED DEVICES - Reverse battery protection circuits for devices powered by batteries coupled in parallel can include both P-channel and N-channel MOSFETs. Each positive battery terminal connector of a battery-powered device can be coupled to a gate of an N-channel MOSFET or to both a gate of an N-channel MOSFET and a gate of a P-channel MOSFET. In some embodiments, each negative battery terminal connector of the device can be connected to a gate of a P-channel MOSFET. In the event of a reverse battery connection, one or more of the protection circuit's P-channel and N-channel MOSFETS can switch to a non-conductive state to isolate the device's load from an incorrectly installed battery and prevent the incorrectly installed battery and/or other parallel-coupled battery from prematurely discharging. Methods of protecting a load from a reverse battery connection are also provided, as are other aspects. | 09-18-2014 |
| 20140262772 | MAINTAINING ELECTRODE FUNCTION DURING MANUFACTURE WITH A PROTECTIVE LAYER - The present disclosure relates to an electrochemical test sensor for detecting the concentration of an analyte in a fluid sample. The test sensor includes a working electrode, a counter electrode, and a trigger electrode. A temporary protective layer overlies the trigger electrode and helps to maintain the function of the trigger electrode during test sensor manufacture. | 09-18-2014 |
| 20140244199 | Method Of Determining Information Of A Test Sensor - A method of determining auto-calibrating information of a test sensor includes providing an optical read head that includes a light source, a light guide and a detector. The read head forms an opening that is sized to receive a test sensor. The detector includes a linear-detector array or single detector. A test sensor is provided having apertures formed therein. The test sensor is placed in the opening of the optical read head. Light is transmitted from the light source through the apertures. The light transmitted through the apertures using the detector or detecting the absence of light being transmitted through the test sensor using the detector is detected. The detected light or the absence of detected light information from the detector is used to determine the auto-calibration information of the test sensor. | 08-28-2014 |
| 20140242160 | CALCIUM SUPPLEMENT - An oral dosage form for administration to an animal comprising a biologically utilizable form of calcium and an extended release system that maintains the calcium level in the animal's bloodstream at a substantially beneficial level for a defined period of time. | 08-28-2014 |
| 20140241958 | CARTRIDGE AND SENSOR-DISPENSING INSTRUMENT - A disposable cartridge adapted to be used with a sensor-dispensing instrument comprises a housing, test sensors, a mechanical mechanism and moveable seals. The housing forms at least one opening therethrough. The test sensors are stacked in the housing. The test sensors are adapted to assist in testing at least one analyte. The mechanical mechanism is adapted to urge the test sensors in a first direction. One of the test sensors is positioned for ejection from the cartridge. The moveable seals is adapted to be in a closed position that seals the at least one opening so as to provide a substantially moisture-proof and a substantially air-tight cartridge, and one of the moveable seals is adapted to be in an open position that allows one of the test sensors to be moved therethrough. | 08-28-2014 |
| 20140235797 | Polymer Comprising A Plurality Of Phenothiazine Groups And Methods Of Making The Same - A non-leaching mediator may include a polymer comprising the general formula (VIII): | 08-21-2014 |
| 20140235678 | Topical Ophthalmological Pharmaceutical Composition containing Sorafenib - The present invention relates to topical ophthalmological pharmaceutical compositions containing sorafenib or a pharmaceutically acceptable salt thereof or a polymorph, hydrate or solvate thereof and its process of preparation and its use for treating ophthalmological disorders. | 08-21-2014 |
| 20140216930 | Underfill Recognition Biosensor - A biosensor with an underfill recognition system assesses whether to analyze a sample for one or more analytes in response to the volume of the sample. The underfill recognition system applies polling and test excitation signals to the sample. The polling signals generate one or more polling output signals, which maybe used to detect when a sample is present and to determine whether the sample has sufficient volume for analysis. The test excitation signal generates one or more test output signals, which may be used to determine one or more analyte concentrations in the sample. | 08-07-2014 |
| 20140209460 | Biosensor Systems for Determining Analyte Concentration Based on Complex Index Functions - A biosensor system determines analyte concentration from an output signal generated from a light-identifiable species or a redox reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals or determined analyte concentrations with one or more complex index function extracted from the output signals or from other sources. The complex index functions determine at least one slope deviation value, ΔS, or normalized slope deviation from one or more error parameters. The slope-adjusted correlation between analyte concentrations and output signals may be used to determine analyte concentrations having improved accuracy and/or precision from output signals including components attributable to bias. | 07-31-2014 |
| 20140202881 | Electrochemical Biosensor - According to one embodiment of the present invention, an electrochemical sensor ( | 07-24-2014 |
| 20140193894 | SENSOR AND PACKAGE - A fluid sensor comprises a formed plastic body and a reagent. The body has a top face with an integral first surface. The body also has a bottom face opposed to the first surface and a sidewall that extends from the periphery of the top face. The first surface is adapted to accept a fluid sample. The reagent is disposed on the integral first surface and causes a color change detectable on the bottom face when the reagent reacts with an analyte in the fluid sample. | 07-10-2014 |
| 20140179745 | TOPICAL OPHTHALMOLOGICAL PHARMACEUTICAL COMPOSITION CONTAINING REGORAFENIB - The present invention relates to topical ophthalmological pharmaceutical compositions containing regorafenib, a hydrate, solvate or pharmaceutically acceptable salt thereof or a polymorph thereof but without hydrophobic silica and its process of preparation and its use for treating ophthalmological disorders. | 06-26-2014 |
| 20140174951 | Method Of Using A Biosensor - A biosensor ( | 06-26-2014 |
| 20140174922 | ELECTROCHEMICAL TEST SENSOR - An electrochemical test sensor includes a lid and a base. The base has a length and a width. The length of the base is greater than the width of the base. The base includes at least a working electrode, a counter electrode and at least three test-sensor contacts for electrically connecting to a meter. The at least three test-sensor contacts are spaced along the length of the base from each other. The base and the lid assist in forming a fluid chamber for receiving the fluid sample. The electrochemical test sensor further includes a reagent to assist in determining the concentration of the analyte in the fluid sample. | 06-26-2014 |
| 20140174145 | INTEGRATORS FOR SENSOR APPLICATIONS - Embodiments herein provide processing of sensor signals (e.g., signals representative of a level of an analyte in a body). An electronics assembly may include a sensor contact configured to receive a sensor signal from a sensor assembly, an integrator circuit configured to provide an integrator output signal representative of the sensor signal integrated from a first time to a second time, and a reset circuit configured to reset the integrator output signal in response to a reset signal. The electronics assembly may also include a processor circuit configured to determine a value of the integrator output signal and to provide the reset signal to the reset circuit when an integration interval has elapsed from the first time. The integration interval may be based at least in part on the integrator output signal. | 06-26-2014 |
| 20140161667 | AUTOMATED ANALYTE SENSOR ORDERING METHODS AND APPARATUS - Methods, systems, and apparatus adapted to automate ordering of test strips for use in an analyte meter device are disclosed. The method, system and apparatus includes inputting information from an indicia on a package of test strips indicative of a quantity of test strips in the package; tracking a number of test strips used in the analyte meter device; and generating an automatic order for additional test strips based on a signal indicating that a reorder threshold has been reached. Numerous additional features and aspects are disclosed. | 06-12-2014 |
| 20140156300 | ANALYTE-TESTING DEVICE - A device adapted to determine an analyte concentration of a fluid sample using a test sensor. The device comprises a display adapted to display information to a user. The device further comprises at least one user-interface mechanism adapted to allow the user to interact with the device. The device further comprises a body portion including at least one opening formed therein, the at least one opening being of sufficient size to receive the test sensor. The device further comprises a memory adapted to store a plurality of stored analyte concentrations. The device further comprises a processing feature adapted to inhibit the stored analyte concentrations from being displayed on the display. | 06-05-2014 |
| 20140154718 | Biosensors and Porous Particle Reagent Compositions - A reagent composition for a biosensor sensor strip is disclosed that provides for rapid rehydration after drying. The composition includes porous particles and is preferably formed as a colloidal suspension. The dried reagent composition including porous particles may provide analytically useful output from the sensor strip in a shorter time period than observed from dried reagent compositions using solid particles. The output signal from the porous particle compositions may be correlated to the analyte concentration of a sample within about two seconds. In this manner, an accurate concentration determination of an analyte concentration in a sample may be obtained in less time than from sensor strips including conventional compositions. The reagent composition including the porous particles also may allow for the redox reaction between the reagents and the analyte to reach a maximum kinetic performance in a shorter time period than observed from conventional sensor strips. | 06-05-2014 |
| 20140151246 | Gated Voltammetry Methods - A sensor system, device, and methods for determining the concentration of an analyte in a sample is described. Gated voltammetric pulse sequences including multiple duty cycles of sequential excitations and relaxations may provide a shorter analysis time and/or improve the accuracy and/or precision of the analysis. The disclosed pulse sequences may reduce analysis errors arising from the hematocrit effect, variance in cap-gap volumes, non-steady-state conditions, mediator background, a single set of calibration constants, under-fill, and changes in the active ionizing agent content of the sensor strip. | 06-05-2014 |
| 20140147872 | OXIDIZABLE SPECIES AS AN INTERNAL REFERENCE IN CONTROL SOLUTIONS FOR BIOSENSORS - Testing of the performance of an electrochemical meter used to measure the presence of an analyte in a biological sample, particularly glucose in whole blood, includes introducing a control solution containing a predetermined amount of the analyte and a predetermined amount of an internal reference compound. The internal reference compound is selected such that it is oxidized at a potential greater than that used to oxidize the analyte, thereby making it possible to distinguish the control solution from a biological sample. | 05-29-2014 |
| 20140142604 | PERMANENT MAGNET LANCING DEVICE - A lancing device and a method for using the lancing device includes a plunger mechanism having a permanent magnet housed therein. The lancing device includes a movable element having at least one attracting object and at least one repelling object. The attracting object attracts the permanent magnet to move the plunger into a retracted position. The repelling object repels the permanent magnet to move the plunger into a lancing position to pierce the skin of a test subject. The use of the permanent magnet in the plunger mechanism reduces or eliminates multiple punctures due to plunger bounce or oscillation that can occur while a body fluid sample is being drawn. | 05-22-2014 |
| 20140124382 | ELECTROCHEMICAL TEST SENSOR WITH REDUCED SAMPLE VOLUME - An electrochemical test sensor for detecting the analyte concentration of a fluid test sample includes a base, a dielectric layer, a reagent layer and a lid. The base provides a flow path for the test sample having on its surface a counter electrode and a working electrode adapted to electrically communicate with a detector of electrical current. The dielectric layer forms a dielectric window therethrough. The reagent layer includes an enzyme that is adapted to react with the analyte. The lid is adapted to mate with the base and to assist in forming a capillary space with an opening for the introduction of the test sample thereto. At least a portion of the width of the counter electrode is greater than the width of the working electrode. | 05-08-2014 |
| 20140107689 | LANCING DEVICE - A lancing mechanism is adapted to move between a resting, cocking and a puncture position. The lancing mechanism comprises a lancet holder adapted to receive a lancet, a shaft attached to the lancet holder, at least one drive spring and at least one damping spring. The drive spring surrounds at least a portion of the shaft and drives the lancing mechanism from the cocking position to the puncture position. The damping spring moves the lancing mechanism from the puncture position to the resting position. The drive spring is located at least partially within the damping spring. | 04-17-2014 |
| 20140106459 | METHOD OF USING A CONTROL SOLUTION AND PREPARING FOR TESTING USING THE SAME - A method of distinguishing a control solution from a sample in an electrochemical test sensor is performed. The method includes adding a control marker to the control solution. The control solution includes the control marker and analyte. The test sensor includes working and counter electrodes, and a reagent. A potential is applied to the test sensor to oxidize the control marker and the analyte. The resulting electrical current is measured. A potential is applied to the test sensor lower than the other potential in which the potential is sufficient to oxidize the analyte and not the control marker. The resulting electrical current is measured. Determining whether a control solution or a sample is present based on the measured electrical currents. To increase the measured current, a salt may be added to the control solution in an amount sufficient to increase the electrical current by at least 5% as compared to a control solution in the absence of a salt. | 04-17-2014 |
| 20140105892 | HIGH CONCENTRATION ANTIBODY AND PROTEIN FORMULATIONS - Provided are salt-free antibody and other protein formulations that are substantially isosmotic and of low viscosity. Also provided are methods for the treatment of diseases using the disclosed formulations. | 04-17-2014 |
| 20140093895 | SELF-CONTAINED TEST SENSOR - A test strip to assist in determining the concentration of an analyte in a fluid sample comprises a base, at least one tab and a break line. The base includes a capillary channel and a test element. The capillary channel is in fluid communication with the test element. The test element is adapted to receive the fluid sample. The at least one tab is removably attached to the base. The capillary channel extends from the base into a portion of the tab. The break line intersects the capillary channel in which an inlet to the capillary channel is exposed along the break line when the tab is separated from the base. | 04-03-2014 |
| 20140083848 | SYSTEM AND APPARATUS FOR DETERMINING TEMPERATURES IN A FLUID ANALYTE SYSTEM - A test sensor includes a body, a first conductive trace, a second conductive trace, and a third conductive trace. The body includes a first region that has a fluid-receiving area, a second region separate from the first region, and a first temperature sensing interface disposed at or adjacent to the fluid-receiving area. The fluid-receiving area receives a sample. The first trace is disposed on the body, and at least a portion of the first trace is disposed in the first region. The second and third traces are disposed on the body. The third trace extends from the first to the second regions. The third trace is connected to the first trace at the first temperature sensing interface. The third trace includes a different material than the first trace. A first thermocouple is formed at the first temperature sensing interface. The thermocouple provides temperature data to determine an analyte concentration. | 03-27-2014 |
| 20140079607 | CARTRIDGE AND SENSOR-DISPENSING INSTRUMENT - A disposable cartridge adapted to be used with a sensor-dispensing instrument comprises a housing, test sensors, a mechanical mechanism and moveable seals. The housing forms at least one opening therethrough. The test sensors are stacked in the housing. The test sensors are adapted to assist in testing at least one analyte. The mechanical mechanism is adapted to urge the test sensors in a first direction. One of the test sensors is positioned for ejection from the cartridge. The moveable seals is adapted to be in a closed position that seals the at least one opening so as to provide a substantially moisture-proof and a substantially air-tight cartridge, and one of the moveable seals is adapted to be in an open position that allows one of the test sensors to be moved therethrough. | 03-20-2014 |
| 20140074139 | LANCING DEVICE - A lancing mechanism is adapted to move between a resting, cocking and a puncture position. The lancing mechanism comprises a lancet holder adapted to receive a lancet, a shaft attached to the lancet holder, at least one drive spring and at least one damping spring. The drive spring surrounds at least a portion of the shaft and drives the lancing mechanism from the cocking position to the puncture position. The damping spring moves the lancing mechanism from the puncture position to the resting position. The drive spring is located at least partially within the damping spring. | 03-13-2014 |
| 20140067309 | Method Of Determining Auto-Calibration Of A Test Sensor - A method of determining auto-calibrating information of a test sensor includes providing an optical read head that includes a light source, a light guide and a detector. The read head forms an opening that is sized to receive a test sensor. The detector includes a linear-detector array or single detector. A test sensor is provided having apertures formed therein. The test sensor is placed in the opening of the optical read head. Light is transmitted from the light source through the apertures. The light transmitted through the apertures using the detector or detecting the absence of light being transmitted through the test sensor using the detector is detected. The detected light or the absence of detected light information from the detector is used to determine the auto-calibration information of the test sensor. | 03-06-2014 |
| 20140065212 | COATED PHARMACEUTICAL COMPOSITION CONTAINING REGORAFENIB - The present invention relates to a coated pharmaceutical composition containing regorafenib, a hydrate, solvate, metabolite or pharmaceutically acceptable salt thereof or a polymorph thereof and its process of preparation and its use for treating disorders. | 03-06-2014 |
| 20140061062 | Biosensor Performance Increasing Methods Having Enhanced Stability and Hematocrit Performance - The present invention relates to electrochemical sensor strips and methods of determining the concentration of an analyte in a sample or improving the performance of a concentration determination. The electrochemical sensor strips may include at most 8 μg/mm | 03-06-2014 |
| 20140061045 | ELECTROCHEMICAL TEST SENSOR AND METHOD OF FORMING THE SAME - A method of depositing reagent on an electrochemical test sensor adapted to determine information relating to an analyte includes providing a base and forming an electrode pattern on the base. The method further includes depositing the reagent on at least the electrode pattern using a reagent-dispensing system. The reagent-dispensing system applies mechanical force to the reagent in the reagent-dispensing system to assist in providing a wet reagent droplet on at least the electrode pattern. | 03-06-2014 |
| 20140027308 | SYSTEM AND METHOD FOR DETECTING USED AND DRIED SENSORS - Systems and methods for detecting dried test strips are provided, where a dried test strip may be one that has been re-inoculated with a biological sample after having already been previously inoculated with another sample at an earlier time (e.g., hours or days before). In various aspects, a biosensor such as an amperometric glucose biosensor (“meter”) may apply one or more input electrical signals to an inoculated test strip having at least a pair of electrodes in contact with the biological sample. The meter may measure output current value(s) resulting in response to the input electrical signals applied to the test strip. The meter may determine whether the test strip is a dried test strip by comparing a ratio of the measured output current value(s) with a boundary ratio value. | 01-30-2014 |
| 20130345402 | Devices and Methods for Integrated Continuous Manufacturing of Biological Molecules - The present invention relates to a process and apparatus for purifying a molecule of interest from a heterogeneous clarified fluid mixture. The apparatus of the invention generally comprises a continuous perfusion fermentation system, a continuous particle removal system integrated with the perfusion fermentation system; and a continuous purification system integrated with the particle removal system, which is maintained under sterile conditions. The process comprises filtering a heterogeneous clarified fluid mixture by continuous ultrafiltration at a specific flow rate below the transition point of the molecule of interest in the pressure-dependent region of the flux versus TMP curve, wherein the specific flow rate is maintained substantially constant throughout the continuous ultrafiltration. | 12-26-2013 |
| 20130344585 | Devices and Methods for Integrated Continuous Manufacturing of Biological Molecules - The present invention relates to a process and apparatus for purifying a molecule of interest from a heterogeneous clarified fluid mixture. The apparatus of the invention generally comprises a continuous perfusion fermentation system, a continuous particle removal system integrated with the perfusion fermentation system; and a continuous purification system integrated with the particle removal system, which is maintained under sterile conditions. The process comprises filtering a heterogeneous clarified fluid mixture by continuous ultrafiltration at a specific flow rate below the transition point of the molecule of interest in the pressure-dependent region of the flux versus TMP curve, wherein the specific flow rate is maintained substantially constant throughout the continuous ultrafiltration. | 12-26-2013 |
| 20130343963 | TEST SENSOR PACKAGE - A fluid sensor comprises a formed plastic body and a reagent. The body has a top face with an integral first surface. The body also has a bottom face opposed to the first surface and a sidewall that extends from the periphery of the top face. The first surface is adapted to accept a fluid sample. The reagent is disposed on the integral first surface and causes a color change detectable on the bottom face when the reagent reacts with an analyte in the fluid sample. | 12-26-2013 |
| 20130324822 | MULTISTRIP CARTRIDGE - A test meter for analyzing a body fluid sample applied to a test strip includes an outer housing having an opening, an actuator, and a cartridge positioned adjacent the outer housing. The cartridge further includes a dispensing member connected to the actuator, a plurality of stacked test strips biased toward the dispensing member, and a cartridge outer housing that is adjacent at least a portion of the dispensing member. Each time the actuator is actuated, the dispensing member is rotated to cause movement of one test strip from the plurality of stacked test strips through the opening, and another test strip is biased toward the dispensing member. | 12-05-2013 |
| 20130310867 | SINGLE-PUNCTURE LANCING SYSTEM - A lancing mechanism is adapted to move between resting, cocking and puncture positions and comprises a lancet holder, a shaft, at least one spring and a mass. The shaft is attached to the lancet holder and has an enlarged end opposite the lancet holder. The spring surrounds at least a portion of the shaft and has first and second portions. The second portion of the spring is attached to the lancet holder. The spring drives the lancing mechanism between the cocking and puncture positions. The mass is located along the spring with the first and second portions of the spring extending on opposite sides of the mass. The mass is distinct from the lancet holder. The first portion dampens the lancing mechanism when moving from the puncture position to the resting position. | 11-21-2013 |
| 20130298648 | TEMPERATURE SENSING ANALYTE SENSORS, SYSTEMS, AND METHODS OF MANUFACTURING AND USING SAME - An analyte sensor is provided for detecting an analyte concentration level in a bio-fluid sample. The analyte sensor has a base, a first electrode and a second electrode wherein a thermocouple portion is provided integral with the second electrode thereby enabling on-sensor temperature measurement capability. In some embodiments, two and only two electrical contact engagement portions are provided thereby simplifying electrical contact. Manufacturing methods and systems utilizing the analyte sensors are provided, as are numerous other aspects. | 11-14-2013 |
| 20130291626 | AUTO-CODED ANALYTE SENSORS AND APPARATUS, SYSTEMS, AND METHODS FOR DETECTING SAME - In some aspects, an analyte sensor is provided. The analyte sensor has a plurality of fuse members associated therewith. The fuse members may be burned in sequence and the burn values (related to current, voltage, or time) may be used to extract/decode information. The decoded information may include calibration constant, expiration or manufacture date, counterfeiting codes, warnings, etc. Systems and methods for burning and detecting such burn values of the plurality of fuse members and decoding the coded information related to the sensor are provided, as are numerous other aspects. | 11-07-2013 |
| 20130288282 | Temperature-Adjusted Analyte Determination For Biosensor Systems - A biosensor system determines analyte concentration from an output signal generated by an oxidation/reduction reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals at one temperature to determining analyte concentrations from output signals at other temperatures. The temperature-adjusted correlation between analyte concentrations and output signals at a reference temperature may be used to determine analyte concentrations from output signals at a sample temperature. | 10-31-2013 |
| 20130261406 | METHOD FOR BUILDING AN ALGORITHM FOR CONVERTING SPECTRAL INFORMATION - A system for determining the concentration of an analyte in at least one body fluid in body tissue comprises an infrared light source, a body tissue interface, a detector, and a central processing unit. The body tissue interface is adapted to contact body tissue and to deliver light from the infrared light source to the contacted body tissue. The detector is adapted to receive spectral information corresponding to infrared light transmitted through the portion of body tissue being analyzed and to convert the received spectral information into an electrical signal indicative of the received spectral information. The central processing unit is adapted to compare the electrical signal to an algorithm built upon correlation with the analyte in body fluid, the algorithm adapted to convert the received spectral information into the concentration of the analyte in at least one body fluid. | 10-03-2013 |
| 20130257352 | RAPID CHARGING AND POWER MANAGEMENT OF A BATTERY-POWERED FLUID ANALYTE METER - A system and method is described for rapid charging and power management of a battery for a meter. A charger component is operably associated with the meter and is capable of executing a rapid charge algorithm for a rechargeable battery. The algorithm includes monitoring for a connection to an external power source and implementing a charging routine of a battery at a first charge rate and then at a second charge rate. The second charge rate is lower than the first charge rate. A temperature rise in the rechargeable battery due to the first charge rate has a negligible heat transfer effect on the fluid sample. The meter can also include a power switch for controlling current flow to a battery fuel gauge. The power switch is open when the meter enters into a sleep mode. The state of battery charge is determined after the meter exits the sleep mode. | 10-03-2013 |
| 20130233726 | METHOD OF CORRECTING FOR OXYGEN EFFECT ON TEST SENSORS - An electrochemical test sensor is adapted to measure glucose and correct for the oxygen effect in a fluid sample. The test sensor comprises a base, first and second working electrodes, and a counter electrode. The first working electrode includes glucose oxidase, a mediator and peroxidase. The second working electrode includes glucose oxidase and the mediator. The first working electrode, the second working electrode and the counter electrode are located on the base. In other embodiments, an electrochemical test sensor is adapted to measure cholesterol, lactate, pyruvate or xanthine and correct for the oxygen effect in a fluid sample. | 09-12-2013 |
| 20130228472 | Gated Voltammetry Devices - A sensor system, device, and methods for determining the concentration of an analyte in a sample is described. Gated voltammetric pulse sequences including multiple duty cycles of sequential excitations and relaxations may provide a shorter analysis time and/or improve the accuracy and/or precision of the analysis. The disclosed pulse sequences may reduce analysis errors arising from the hematocrit effect, variance in cap-gap volumes, non-steady-state conditions, mediator background, a single set of calibration constants, under-fill, and changes in the active ionizing agent content of the sensor strip. | 09-05-2013 |
| 20130225809 | PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS - This invention relates to pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis. | 08-29-2013 |
| 20130216452 | VENT CONFIGURATION FOR A BLOOD SAMPLER - A blood sampler device includes a blood collector and a sampler body. The blood collector is designed to collect a sample of a fluid, such as blood, from a user and to be inserted into the sampler body, such that the collected blood can be discharged into a liquid chamber in the sampler body to mix with a liquid stored in the liquid chamber for testing. The blood collector includes vents that are designed to facilitate the flow of air out of the liquid chamber during this insertion, such that a lower and more consistent pressurization can be achieved within the liquid chamber. This design may also increase user comfort and enhance the accuracy of testing performed on the collected fluid. | 08-22-2013 |
| 20130196421 | MARKER FOR READINGS TAKEN FROM ALTERNATIVE SITE TESTS - A meter for determining the concentration of an analyte in a fluid sample comprises a memory device, electrical circuitry and a detection device for distinguishing between an alternative site test and a standard site test. The memory device is adapted to store information. The electrical circuitry is adapted to determine the analyte concentration of the fluid sample located on a test sensor. The electrical circuitry is in electronic communication with the memory device. The electrical circuitry communicates the determined analyte concentration to the memory device for storage. | 08-01-2013 |
| 20130188302 | HEALTH DATA MANAGEMENT DEVICE - A device for managing health data provides a first housing portion including a data storage system that stores health data and a second housing portion including a data communications element. The data communications element provides data communications between the data storage system and a processing device that processes the health data according to a data-management software. The first housing portion and the second housing portion are connected by a cable that communicates signals between the data communications element and other components in the first housing portion. Another device for managing health data provides a first housing portion including a health data management system and a data communications element that provides data communications between the health data management system and an external processing device. The second housing portion is removably coupled to the first housing portion, and includes at least one component used by the health data management system. | 07-25-2013 |
| 20130183699 | METHOD OF DIFFERENTIATING BETWEEN BLOOD AND CONTROL SOLUTIONS CONTAINING A COMMON ANALYTE - Glucose measured in blood samples is distinguished from glucose measured in the control solutions used to test the optical instruments which make such measurements. The control solutions contain a labeling substance recognized by the optical instrument to distinguish glucose measurements made of control solutions from those made of blood samples. | 07-18-2013 |
| 20130183268 | DRUG COMBINATIONS WITH FLUORO-SUBSTITUTED OMEGA-CARBOXYARYL DIPHENYL UREA FOR THE TREATMENT AND PREVENTION OF DISEASES AND CONDITIONS - The present invention relates to drug combinations and pharmaceutical compositions for treating hyperproliferative disorders such as cancer including non-small cell lung carcinoma, said drug combination comprising (1) a fluoro-substituted-diaryl urea of Formula (I), (2) at least one antifolate and optionally (3) at least one platinum complex antineoplastic nucleic acid binding agent, where any of these components can be present in the form of a pharmaceutically acceptable salt or other derivative thereof. | 07-18-2013 |
| 20130171028 | ANALYTE MONITOR - An analyte meter for an analyte test strip includes a light source configured to emit a light having a wavelength substantially similar to the maximum absorption band of Hb, an optics assembly configured to direct the light emitted by the light source to a test strip, and a photodetector configured to quantitatively detect light emanating from the test strip and to generate a signal correlating to an analyte concentration in the test strip. | 07-04-2013 |
| 20130168403 | GLUCOSE MEASUREMENT SYSTEM WITH HIGH-CAPACITY CARTRIDGE AND CAPABILITY OF MORE FREQUENT REPLENISHMENT - The present disclosure relates to packaging containers for holding a plurality of test sensors. The packaging container may include a first semi-circular housing and a second semi-circular housing. The first semi-circular housing has a plurality of first test sensor containing regions. Each of the plurality of the first test sensor containing regions is adapted to contain at least one test sensor having a top portion covered by a foil cover. The second semi-circular housing has a plurality of second test sensor containing regions. Each of the plurality of the second test sensor containing regions is adapted to contain at least one test sensor. The second semi-circular housing has a top portion. The first semi-circular housing and the second semi-circular housing are positioned adjacent to each other. | 07-04-2013 |
| 20130161206 | METHODS OF USING AN ELECTROCHEMICAL BIOSENSOR - According to one embodiment of the present invention, an electrochemical sensor ( | 06-27-2013 |
| 20130143818 | Factor VIII Glycoforms - The invention concerns glycosylated proteins having human factor VIII activity. In a preferred embodiment, the protein is glycosylated with oligosaccharides that include an alpha-(2,6)-linked sialic acid and a bisecting GlcNAc linked to a core beta-mannose. | 06-06-2013 |
| 20130143055 | RADICALLY POLYMERIZABLE PHENOTHIAZINE MACROMONOMER FOR USE IN THE COATING OF MEDICAL DEVICES - The present invention is directed to phenothiazine-base macromonomer compounds and methods of making the same. | 06-06-2013 |
| 20130131122 | Fluro substituted Omega-Carboxyaryl Diphenyl Urea for the Treatment and Prevention of Diseases and Conditions - A compound of Formula (I): | 05-23-2013 |
| 20130126350 | Mediator For Test Sensor - A method of forming a 3-phenylimino-3H-phenothiazine or a 3-phenylimino-3H-phenoxazine mediator includes providing a first reactant including phenothiazine or phenoxazine, providing a first solvent, providing a second reactant and providing a second solvent. The first reactant, first solvent, second reactant and second solvent are combined to form a reactants solution. Sodium persulfate is added to the reactants solution to couple the first and second reactants resulting in a reaction solution including the 3-phenylimino-3H-phenothiazine or the 3-phenylimino-3H-phenoxazine mediator. | 05-23-2013 |
| 20130122098 | Method and composition to improve absorption of therapeutic agents - A tablet with an enhanced dissolution profile for a medicinally active ingredient such as aspirin and methods for making the tablet. The tablet comprises a blend of crystals of the medicinally active ingredient and a dissolution aid such as sodium or calcium carbonate or bicarbonate that coats the crystals upon co-milling. The blend is then compressed to form tablets that have an enhanced dissolution profile for the medicinally active ingredient. | 05-16-2013 |
| 20130098778 | Concentration Determination in a Diffusion Barrier Layer - The present invention relates to improved electrochemical biosensor strips and methods for determining the concentration of an analyte in a sample. By selectively measuring a measurable species residing in a diffusion barrier layer, to the substantial exclusion of the measurable species residing exterior to the diffusion barrier layer, measurement errors introduced by sample constituents, such as red blood cells, and manufacturing variances may be reduced. | 04-25-2013 |
| 20130078724 | Control Solution For Use In An Electrochemical System - A method of distinguishing a control solution from a sample in an electrochemical test sensor is performed. The method includes adding a control marker to the control solution. The control solution includes the control marker and analyte. The test sensor includes working and counter electrodes, and a reagent. A potential is applied to the test sensor to oxidize the control marker and the analyte. The resulting electrical current is measured. A potential is applied to the test sensor lower than the other potential in which the potential is sufficient to oxidize the analyte and not the control marker. The resulting electrical current is measured. Determining whether a control solution or a sample is present based on the measured electrical currents. To increase the measured current, a salt may be added to the control solution in an amount sufficient to increase the electrical current by at least 5% as compared to a control solution in the absence of a salt. | 03-28-2013 |
| 20130071869 | Analysis Compensation Including Segmented Signals - A biosensor system determines analyte concentration from an output signal generated from a light-identifiable species or a redox reaction of the analyte. The biosensor system compensates at least 50% of the total error in the output signal with a primary function and may compensate a portion of the residual error with at least one residual function. An SSP function may serve as the primary function, first residual function, or second residual function. Preferably, when the SSP function serves as the first residual function, the SSP function compensates at least 50% of the residual error remaining after primary compensation. Preferably, when the SSP function serves as the second residual function, the SSP function compensates at least 50% of the residual error remaining after primary and first residual compensation. The error compensation provided by the primary, first residual, and second residual functions may be adjusted with function weighing coefficients. | 03-21-2013 |
| 20130061663 | METHOD AND ASSEMBLY FOR DETERMINING THE TEMPERATURE OF A TEST SENSOR - An assembly determines an analyte concentration in a sample of body fluid. The assembly includes a test sensor having a fluid-receiving area for receiving a sample of body fluid, where the fluid-receiving area contains a reagent that produces a measurable reaction with an analyte in the sample. The assembly also includes a meter having a port or opening configured to receive the test sensor; a measurement system configured to determine a measurement of the reaction between the reagent and the analyte; and a temperature-measuring system configured to determine a measurement of the test-sensor temperature when the test sensor is received into the opening. The meter determines a concentration of the analyte in the sample according to the measurement of the reaction and the measurement of the test-sensor temperature. | 03-14-2013 |
| 20130056480 | BIOPHARMACEUTICAL PRODUCT STORAGE SYSTEM - A biopharmaceutical product storage system is disclosed. In one embodiment, the system includes a polymeric product container for storage of a biopharmaceutical product, a protective envelope for housing the container, and a cushioning layer disposed between the container and the envelope. The protective envelope and the cushioning layer include mineral fibers that protect and insulate the polymeric product container during handling, transport, and storage. Thus, the combination of the polymeric product container, the protective envelope, and the cushioning layer, the system substantially prevents leakage of the biopharmaceutical product during product handling, transport, and storage. In addition, where the biopharmaceutical product is frozen, the system substantially prevents leakage of product during freeze-storage-thaw cycles, during which temperatures range from −100° C. to 8° C. | 03-07-2013 |
| 20130053814 | DEVICE - The present application is directed to devices. The device may used for connecting a closed receptacle and a container, such as a syringe. | 02-28-2013 |
| 20130044119 | ANALYTE-TESTING DEVICE - A device adapted to determine an analyte concentration of a fluid sample using a test sensor. The device comprises a display adapted to display information to a user. The device further comprises at least one user-interface mechanism adapted to allow the user to interact with the device. The device further comprises a body portion including at least one opening formed therein, the at least one opening being of sufficient size to receive the test sensor. The device further comprises a memory adapted to store a plurality of stored analyte concentrations. The device further comprises a processing feature adapted to inhibit the stored analyte concentrations from being displayed on the display. | 02-21-2013 |
| 20130040362 | Method for Activation and Conjugation of Biomolecules - The present invention is directed to a method for producing a biomolecule conjugate where the method is integrated into a single unit operation. | 02-14-2013 |
| 20130018597 | DETECTION OF CONTAMINATION AT SENSOR CONTACTS - Embodiments herein provide detection of contamination at one or more contacts of a sensor system. The sensor system includes a sensor assembly and an electronics assembly communicatively coupled together by one or more contacts. The sensor assembly passes a sensor signal to the electronics assembly for further processing. The electronics assembly includes a detection contact for detecting contamination on or near one or more contacts of the sensor assembly and/or the electronics assembly. A switch selectively couples the detection contact to a bias voltage during a measurement mode and to a reference voltage during a detection mode, the reference voltage being different from the bias voltage. A method of contamination detection includes switching the electronics assembly between the measurement mode and the detection mode, and monitoring for a change in the output signal received by the electronics assembly. | 01-17-2013 |
| 20130012550 | METHODS FOR PROGNOSIS AND MONITORING CANCER THERAPY - The present invention also relates to biomarkers and the use of biomarkers for the prediction and prognosis of cancer as well as the use of biomarkers to monitor the efficacy of cancer treatment. Specifically, this invention relates to the use of HER-2, EGFR, VEGF, u-PA, p-PAI-1, and soluble forms thereof, as biomarkers for cancer, especially for subjects treated with sorafenib. | 01-10-2013 |
| 20120302492 | Antibody Mimetic Scaffolds - Provided herein are protein scaffolds, e.g. antibody mimetic scaffolds, comprising a three finger protein domain that specifically bind to target molecules, polynucleotides encoding such proteins, methods of using such proteins, and libraries of such scaffolds. | 11-29-2012 |
| 20120301468 | ANTI-MN ANTIBODIES AND METHODS OF USING SAME - The invention provides antibodies having an antigenic binding site specifically directed against an MN protein, and methods of using such antibodies in treating and diagnosing an MN-related disorder. | 11-29-2012 |
| 20120289804 | BACK CALIBRATION OF SENSOR DATA - Methods, apparatuses and systems for back calibration of data from a continuous sensor are provided. The continuous sensor may be calibrated periodically by comparing raw sensor values from the sensor to sensor values obtained from a second sensor, such as a blood glucose meter (BGM). Each calibration may produce a calibration factor. In an aspect, the calibration factor may be applied to sensor values acquired prior to the calibration (i.e., back calibration). In a further aspect, a first calibration and a second calibration may be applied to raw sensor values acquired at a time point between the first calibration and the second calibration. The first and second calibrations may be applied to the raw sensor values by weighted averaging according to the proximity of the first and second calibrations to the acquisition time of the raw sensor value. | 11-15-2012 |
| 20120289552 | ARYL UREAS WITH ANGIOGENESIS INHIBITING ACTIVITY - This invention relates to methods of using aryl ureas to treat diseases mediated by the VEGF induced signal transduction pathway characterized by abnormal angiogenesis or hyperpermeability processes. | 11-15-2012 |
| 20120282138 | INTEGRATED FLUID ANALYTE METER SYSTEM - An integrated meter system for determining information related to an analyte of a fluid sample includes a meter including a housing and a plurality of test sensors. Each of the plurality of test sensors includes a penetrating member, a testing portion, and a channel. The channel is adapted to receive the fluid sample. The test sensors are removably located within the housing. At least one of the test sensors is removably connected to an adjacent test sensor. The integrated meter system also includes a test-sensor advancement mechanism that is configured to advance the test sensors. | 11-08-2012 |
| 20120275957 | TEST-SENSOR CARTRIDGE - A test-sensor cartridge comprising a plurality of test sensors adapted to assist in determining an analyte concentration of a fluid sample. The cartridge further comprises a plurality of walls forming a cavity therein. The cavity is adapted to include the plurality of test sensors. At least one of the plurality of walls forms at least one aperture. The cartridge further comprises a lid adapted to enclose the cavity. The cartridge further comprises a locking feature adapted to lock the lid to one or more of the walls. The locking feature is adapted to be disengaged by the at least one aperture receiving a projection of an analyte-testing instrument. | 11-01-2012 |
| 20120273370 | TRANSDERMAL ANALYTE SENSOR ASSEMBLY AND METHODS OF USING THE SAME - A transdermal test sensor assembly adapted to determine an analyte concentration of a fluid sample is disclosed. The assembly comprises a sensor support including at least one reservoir adapted to hold a liquid. The assembly further comprises a test sensor being coupled to the sensor support. The test sensor forms at least one aperture therein. At least a portion of the at least one aperture is adjacent to the at least one reservoir. The assembly further comprises a hydrogel composition positioned on the test sensor. The hydrogel composition is linked to the at least one reservoir via the at least one aperture. | 11-01-2012 |
| 20120269817 | Monoclonal Antibodies Against Tissue Factor Pathway Inhibitor - Isolated monoclonal antibodies that bind human tissue factor pathway inhibitor (TFPI) and the isolated nucleic acid molecules encoding them are provided. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided. Methods of producing the antibodies are also provided. | 10-25-2012 |
| 20120258467 | TRANSDERMAL SYSTEMS, DEVICES, AND METHODS TO OPTICALLY ANALYZE AN ANALYTE - The invention provides transdermal optical analysis systems, test sensors, methods, and kits for determining the presence and/or concentration of at least one analyte in a fluid sample. The system includes a transdermal test sensor including an aqueous material including at least one analyte selective reagent and at least one optically active moiety. The optical system preferably uses fluorescent spectroscopy to correlate fluorescent emission or adsorption from a dye with the analyte concentration of the sample. An optical light source and/or detector may be housed with the aqueous material in a housing or external to the housing of the aqueous material. | 10-11-2012 |
| 20120252046 | TRANSDERMAL SYSTEMS, DEVICES, AND METHODS FOR BIOLOGICAL ANALYSIS - A transdermal test sensor includes a test chamber including a liquid, a reagent system in contact with the liquid, a housing containing the liquid, and a semipermeable membrane. The housing includes an opening, the semipermeable membrane is connected to the housing and covers the opening, and the housing and the semipermeable membrane enclose the liquid and the reagent system. The transdermal test sensor also includes an analyzer in communication with the liquid. When porated tissue is contacted with the semipermeable membrane and sufficient time is allowed for a fluid sample to traverse the porated tissue and for an analyte in the fluid sample to enter the liquid in the transdermal sensor through the semipermeable membrane, a change in at least one optical property or at least one electrical property of the liquid is detected. The change detected is then correlated with the analyte concentration in the fluid sample. | 10-04-2012 |
| 20120244295 | METHOD OF DEFINING ELECTRODES USING LASER-ABLATION AND DIELECTRIC MATERIAL - A method of forming an electrochemical test sensor includes providing a base. Electrochemically-active material is placed on the base. Dielectric material is applied over the electrochemically-active material. A first selected area of the dielectric material is laser-ablated to expose the electrochemically-active material. A second selected area of the dielectric material and the electrochemically-active material are laser-ablated to expose the base. The first selected area is different from the second selected area. A second layer is applied to assist in forming a channel in the test sensor. The channel assists in allowing a fluid sample to contact a reagent located therein. The dielectric material is located between the base and the second layer. | 09-27-2012 |
| 20120230874 | TEST SENSOR AND METHOD FOR MANUFACTURING THE SAME - According to one embodiment of the present invention, an optical-based test sensor for use in the determination of an analyte in a liquid sample is disclosed. The test sensor includes a base, a polymer carrier, and a test membrane. The base has a capillary channel formed in a surface of the base that is adapted to move a liquid sample from an inlet to a reaction area formed in the base. The polymer carrier has a lower surface adhered to the surface of the base and is disposed over at least a portion of the capillary channel. The test membrane, which contains a reagent, is adhered to the lower surface of the polymer carrier and extends from the polymer carrier into the reaction area. | 09-13-2012 |
| 20120228156 | METHOD FOR DISTINGUISHING ELECTROCHEMICAL SENSORS - A method for distinguishing between types of electrochemical test sensors in a meter is disclosed. The method comprises the acts of providing an electrochemical test sensor comprising an enzyme and a chemical additive, contacting the test sensor to the meter to form an electrical connection, applying a potential having a magnitude sufficient to initiate a redox reaction of the chemical additive, and determining which type of electrochemical test sensor is being used based on whether a predetermined signal has been generated after the potential has been applied. The meter is adapted to determine an analyte concentration in a fluid sample. | 09-13-2012 |
| 20120215460 | Temperature-Adjusted Analyte Determination For Biosensor Systems - A biosensor system determines analyte concentration from an output signal generated by an oxidation/reduction reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals at one temperature to determining analyte concentrations from output signals at other temperatures. The temperature-adjusted correlation between analyte concentrations and output signals at a reference temperature may be used to determine analyte concentrations from output signals at a sample temperature. | 08-23-2012 |
| 20120211698 | STABILIZATION OF LIQUID SOLUTIONS OF RECOMBINANT PROTEIN FOR FROZEN STORAGE - The invention relates to a method for stabilizing a bulk solution of recombinant protein for frozen storage, which comprises providing a partially-purified solution of recombinant protein which has a monovalent salt concentration of at least 100 mM, and adding a carbohydrate to said solution in an amount sufficient that, upon freezing, the solution has a glass transition temperature of −56° C. or higher. | 08-23-2012 |
| 20120211361 | Rapid-Read Gated Amperometry Devices - A sensor system, device, and methods for determining the concentration of an analyte in a sample is described. Input signals including multiple duty cycles of sequential excitation pulses and relaxations are input to the sample. One or more signals output from the sample within 300 ms of the input of an excitation pulse may be correlated with the analyte concentration of the sample to improve the accuracy and/or precision of the analysis. Determining the analyte concentration of the sample from these rapidly measured output values may reduce analysis errors arising from the hematocrit effect, mediator background, and other error sources. | 08-23-2012 |
| 20120203085 | NON-INVASIVE SYSTEM AND METHOD FOR MEASURING AN ANALYTE IN THE BODY - A system for determining an analyte concentration in a fluid sample (e.g., glucose) comprises a light source, a detector, and a central processing unit. The detector is adapted to receive spectral information corresponding to light returned from the fluid sample being analyzed and to convert the received spectral information into an electrical signal indicative of the received spectral information. The central processing unit is adapted to compare the electrical signal to an algorithm built upon correlation with the analyte in body fluid. The algorithm is adapted to convert the received spectral information into the analyte concentration in body fluid. Spectral information is delivered from the central processing unit to the light source and used to vary the intensity and timing of the light to improve the accuracy of conversion into analyte concentration. | 08-09-2012 |
| 20120201048 | COMPONENT ILLUMINATION APPARATUS, SYSTEMS, AND ELECTRONIC DEVICES AND METHODS OF MANUFACTURING AND USING SAME - Apparatus for illuminating one or more components of an electronic device having a visual display (e.g., a backlit display), such as one or more keys of keyboards, one or more interface ports, or one or more external surfaces are disclosed. In one or more embodiments, a component illumination apparatus has a visual display and a light guide optically coupled to the visual display and that is adapted to illuminate one or more components external to the visual display. Methods of component illumination and illumination systems are described, as are other embodiments. | 08-09-2012 |
| 20120189497 | SYSTEM AND METHOD FOR REPOSITIONING A DIAGNOSTIC TEST STRIP AFTER INOCULATION - A system for analyzing the concentration of an analyte in a fluid sample comprises a test strip and a meter. The test strip is capable of being inoculated by the fluid sample. The test strip includes a test element, which contains at least one reagent adapted to cause a reaction when brought into contact with the analyte. The meter includes a read-head, a repositioning device, and a display. The read-head is capable of producing a signal indicative of the reaction between the analyte and the at least one reagent. The display is capable of displaying the analyte concentration. The repositioning device is adapted to move the test strip from a loading position to a testing position. The testing position positions the test element proximate to the read-head. | 07-26-2012 |
| 20120185198 | CALIBRATION SYSTEM FOR USE WITH LATERAL FLOW ASSAY TEST STRIPS - A method of adjusting a final signal value measured on a lateral flow assay test strip, by: identifying a pre-determined calibration method for the test strip, wherein the pre-determined calibration method corresponds to the manufacturing lot from which the test strip has been made; measuring signal values while performing a lateral flow assay reaction on a test strip; determining a final signal value; and adjusting the final signal value based upon the identified pre-selected calibration method for the test strip. | 07-19-2012 |
| 20120181991 | RAPID CHARGING AND POWER MANAGEMENT OF A BATTERY-POWERED FLUID ANALYTE METER - A system and method is described for rapid charging and power management of a battery for a meter. A charger component is operably associated with the meter and is capable of executing a rapid charge algorithm for a rechargeable battery. The algorithm includes monitoring for a connection to an external power source and implementing a charging routine of a battery at a first charge rate and then at a second charge rate. The second charge rate is lower than the first charge rate. A temperature rise in the rechargeable battery due to the first charge rate has a negligible heat transfer effect on the fluid sample. The meter can also include a power switch for controlling current flow to a battery fuel gauge. The power switch is open when the meter enters into a sleep mode. The state of battery charge is determined after the meter exits the sleep mode. | 07-19-2012 |
| 20120178693 | Cofactors for Thrombin Activation of Factor VII and Uses Thereof - The invention relates to fusion proteins that bind the enzyme thrombin and enhance the activation of the substrate Factor VII to the product Factor VIIa. The invention is also directed to polynucleotides, vectors, host cells, pharmaceutical compositions, and methods of treatment. | 07-12-2012 |
| 20120171757 | CARTRIDGE AND SENSOR-DISPENSING INSTRUMENT - A disposable cartridge adapted to be used with a sensor-dispensing instrument comprises a housing, test sensors, a mechanical mechanism and moveable seals. The housing forms at least one opening therethrough. The test sensors are stacked in the housing. The test sensors are adapted to assist in testing at least one analyte. The mechanical mechanism is adapted to urge the test sensors in a first direction. One of the test sensors is positioned for ejection from the cartridge. The moveable seals is adapted to be in a closed position that seals the at least one opening so as to provide a substantially moisture-proof and a substantially air-tight cartridge, and one of the moveable seals is adapted to be in an open position that allows one of the test sensors to be moved therethrough. | 07-05-2012 |
| 20120165314 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS - This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis. | 06-28-2012 |
| 20120164130 | Modified Factor IX Polypeptides and Uses Thereof - The invention relates to modified Factor IX polypeptides such as Factor IX polypeptides with one or more amino acid substitutions. The invention also relates to methods of making modified Factor IX polypeptides, and methods of using modified Factor IX polypeptides, for example, to treat patients afflicted with hemophilia B. | 06-28-2012 |
| 20120149048 | METHOD OF DIFFERENTIATING BETWEEN BLOOD AND CONTROL SOLUTIONS CONTAINING A COMMON ANALYTE - Glucose measured in blood samples is distinguished from glucose measured in the control solutions used to test the optical instruments which make such measurements. The control solutions contain a labeling substance recognized by the optical instrument to distinguish glucose measurements made of control solutions from those made of blood samples. | 06-14-2012 |
| 20120142593 | Factor VIII Variants and Methods of Use - A Factor VIII fusion protein or a Factor VIII fusion heterodimer comprising Factor VIII in which an amino acid sequence of a modulator is present in the B-domain, or an amino acid sequence of a modulator replaces some or all of the amino acid sequence of the B-domain is disclosed. Nucleic acids encoding the inventive fusion proteins and fusion heterodimers are also disclosed, as are methods for producing the fusion proteins and fusion heterodimers, pharmaceutical compositions, and methods of treating deficiencies in coagulation with the inventive fusion molecules. | 06-07-2012 |
| 20120142084 | GRAPHICAL INTERFACE FOR ANALYTE METER - Diagnostic systems include a meter that is configured to receive a test sensor during a testing procedure. The diagnostic systems also include a computing device coupled to the meter. The test sensor receives a fluid sample during the testing procedure. The meter includes a measurement system that determines a measurement of a concentration of an analyte in the fluid sample. The computing device receives and processes the measurement from the meter. The computing device has enhanced processing and presentation capabilities that provide visual and/or audio instructions on how to operate the diagnostic system, especially when an error or exceptional condition arises. | 06-07-2012 |
| 20120132542 | Methods Of Using An Electrochemical Biosensor - According to one embodiment of the present invention, an electrochemical sensor ( | 05-31-2012 |
| 20120123227 | Apparatus, Systems, and Methods Adapted to Transmit Analyte Data Having Common Electronic Architecture - Embodiments provide apparatus, systems, and methods adapted to communicate analyte data and/or related information. In a first aspect, the apparatus includes a transmitter/receiver unit which is configurable as either a transmitter or a receiver. The transmitter/receiver unit may be coupled to an on-body sensor and may be configured as a transmitter, or may be coupled to a management unit and may be configured as a receiver as part of a continuous analyte monitoring system. Analyte data communication systems and methods are provided, as are other aspects. | 05-17-2012 |
| 20120121613 | PROTEIN CONJUGATE HAVING AN ENDOPEPTIDASE- CLEAVABLE BIOPROTECTIVE MOIETY - The invention is directed to a procoagulant conjugate having an endopeptidase-activatable procoagulant protein moiety and one or more bioprotective moieties, which are conjugated to one another by a linker that is cleaved by an endopeptidase in situ to release the bioprotective moiety. The invention is also directed to therapeutic uses of the procoagulant conjugate and methods of making the conjugate. | 05-17-2012 |
| 20120104019 | SENSOR RELEASE MECHANISM FOR A METER - A sensor-dispensing instrument adapted to handle a sensor pack contains sensors and performs a test using one of the sensors. The instrument includes an outer housing and a mechanical mechanism for rotating the sensor pack and ejecting one of the sensors from the sensor pack and through a sensor slot on the housing. The instrument also includes a sensor actuator to engage with a sensor disposed in the sensor slot, and a sensor release that is movable to disengage the sensor actuator from the sensor disposed in the sensor slot and permit the discharge of the sensor. The sensor release activates a sensor release mechanism that has a sensor release aid arm, a mounting block, and a pivot pin. The sensor release aid arm contacts the sensor disposed in the sensor slot to assist removal of the sensor from the sensor slot. | 05-03-2012 |
| 20120100625 | Method and Assembly for Determining the Temperature of a Test Sensor - An assembly determines an analyte concentration in a sample of body fluid. The assembly includes a test sensor having a fluid-receiving area for receiving a sample of body fluid, where the fluid-receiving area contains a reagent that produces a measurable reaction with an analyte in the sample. The assembly also includes a meter having a port or opening configured to receive the test sensor; a measurement system configured to determine a measurement of the reaction between the reagent and the analyte; and a temperature-measuring system configured to determine a measurement of the test-sensor temperature when the test sensor is received into the opening. The meter determines a concentration of the analyte in the sample according to the measurement of the reaction and the measurement of the test-sensor temperature. | 04-26-2012 |
| 20120094319 | METHOD OF DISPENSING BIOSENSORS - A storage cartridge for dispensing biosensors used in the determination of an analyte in body fluid comprises a hollow body for housing a stack of biosensors having an open top, a flexible conveying member disposed over the open top of the body, the flexible conveying member having an aperture formed therein for receiving a biosensor from the stack of biosensors, a plate adapted to press the sliding conveying member against the open top to form a substantially moisture-impervious seal around the open top of the body and to permit the conveying member to slide between the plate and the open top, and a biasing mechanism the stack of biosensors towards the open top. | 04-19-2012 |
| 20120088679 | Method for Monitoring Cell Culture - The present invention is directed to a method of monitoring the physiological state of a cell cultivation. Several parameters such as cell viability, growth, metabolic profile, and productivity may be monitored to establish a metabolic fingerprint or metabolomic profile of a cell culture. | 04-12-2012 |
| 20120076171 | SYSTEM AND APPARATUS FOR DETERMINING AMBIENT TEMPERATURES FOR A FLUID ANALYTE SYSTEM - A system and method for rapidly determining ambient temperature in a fluid-analyte meter. The meter includes a housing defining an interior space and an area for receiving a fluid sample. A processor and a first temperature sensor are disposed within the interior space of said the housing. A second temperature sensor is disposed on the housing. One or more processors are configured to determine a first temperature value from temperature data received from the first temperature sensor. The processor(s) are also configured to apply a variable current to a temperature-adjustment source such that the second temperature sensor is adjusted to a predetermined steady-state temperature value different from the first temperature value. The processor(s) are further configured to determine an ambient temperature of an exterior space of the housing based on the applied variable current, pre-determined steady-state temperature, and received first temperature values. | 03-29-2012 |
| 20120067743 | METHOD OF CORRECTING FOR OXYGEN EFFECT ON TEST SENSORS - An electrochemical test sensor is adapted to measure glucose and correct for the oxygen effect in a fluid sample. The test sensor comprises a base, first and second working electrodes, and a counter electrode. The first working electrode includes glucose oxidase, a mediator and peroxidase. The second working electrode includes glucose oxidase and the mediator. The first working electrode, the second working electrode and the counter electrode are located on the base. In other embodiments, an electrochemical test sensor is adapted to measure cholesterol, lactate, pyruvate or xanthine and correct for the oxygen effect in a fluid sample. | 03-22-2012 |
| 20120067734 | PHENOL CROSSLINK FOR SENSOR MEMBRANE - Embodiments herein provide a membrane that is a product of a phenol crosslinked with one or more compounds containing an allyl group. The phenol may be electropolymerized with the allyl-containing compounds to form the crosslinked polymer. Suitable allyl-containing compounds include allylphenol, allylalcohol, allylamine, and allylcarbamide. A membrane may have one type of allyl-containing compound, or, alternatively, two or more types of compounds. As used in an analyte sensing device, a membrane formed from a crosslinked phenol may provide improved interference exclusion, peroxide response, stability, and/or solvent resistance. | 03-22-2012 |
| 20120037921 | Electrical Devices With Enhanced Electrochemical Activity and Manufacturing Methods Thereof - In some aspects, a device is provided having a member with a region of enhanced electrochemical activity. In one aspect, a sensor of enhanced electrochemical activity is provided for detecting an analyte concentration level in a bio-fluid sample. The sensor may include a sensor member of a semiconductor material wherein the sensor member has a surface region of enhanced electrochemical activity. In other aspects, the member may be made of semiconducting foam having a surface region of enhanced electrochemical activity. In some embodiments, the region may be thermally-induced. Manufacturing methods and apparatus are also provided, as are numerous other aspects. | 02-16-2012 |
| 20120037514 | Enzymatic Electrochemical Biosensor - An electrochemical sensor strip has a base and a first electrode and a second electrode on the base. An oxidoreductase enzyme and a mediator are on the first electrode, and a soluble redox species is on the second electrode. The soluble redox species may be an organotransition metal complex, a transition metal coordination complex, an electroactive organic molecule, or mixtures thereof. | 02-16-2012 |
| 20120035640 | LANCING DEVICE FOR ONE SKIN PUNCTURE - A lancing device comprises a main housing, a movable housing, and a damping ring. The main housing forming an inner aperture that encloses a portion of a lancet assembly. The lancet assembly has a lancet body, a lancet-plunger housing, and a lance. The lancet assembly is adapted to move between a resting position, a cocking position, and a puncture position. The movable housing is adjacent to the main housing. The moveable housing is adapted to move from a resting position to a cocking position. The moveable housing is adapted to connect to the lancet assembly. The damping ring is adapted to engage the lancet assembly as the lancet assembly moves from the puncture position back towards the resting position to reduce movement of the lancet assembly back towards the puncture position. | 02-09-2012 |
| 20120031776 | Transient Decay Amperometry - A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the −0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay. | 02-09-2012 |
| 20120027743 | Method for the Treatment of Hemophilia - The present invention is directed to a method for the treatment of hemophilia. | 02-02-2012 |
| 20110313155 | PROCESS OF MAKING 3-PHENYLIMINO-3H-PHENOXAZINE MEDIATOR - A method of forming a 3-phenylimino-3H-phenothiazine or a 3-phenylimino-3H-phenoxazine mediator includes providing a first reactant including phenothiazine or phenoxazine, providing a first solvent, providing a second reactant and providing a second solvent. The first reactant, first solvent, second reactant and second solvent are combined to form a reactants solution. Sodium persulfate is added to the reactants solution to couple the first and second reactants resulting in a reaction solution including the 3-phenylimino-3H-phenothiazine or the 3-phenylimino-3H-phenoxazine mediator. | 12-22-2011 |
| 20110312004 | TEST STRIP WITH MAGNETO-ELASTIC-RESONANCE SENSOR - A test meter system for testing a characteristic of a fluid, the test meter system including a test meter having a housing with an opening adapted to accept a test strip, an interrogation coil within the housing, a pick-up coil within the housing, and a test strip including at least one magneto-electronic-resonance sensor. When the test strip is within the opening, the interrogation coil may utilize magneto-electronic-resonance technology to interrogate the magneto-electronic-resonance sensor and the pick-up coil may be used to sense a resultant oscillation frequency of the magneto-electronic-resonance sensor, the resultant oscillation frequency associated with the characteristic. The test strip may include a plurality of sensors. The sensors may be coated with a coating sensitive to a characteristic of the fluid, where the interrogation reveals information about the fluid characteristic. | 12-22-2011 |
| 20110301857 | Slope-Based Compensation Including Secondary Output Signals - A biosensor system determines analyte concentration from analytic and/or secondary output signals. The biosensor system adjusts a correlation for determining analyte concentrations from output signals with one or more index functions extracted from the output signals. The index functions determine at least one slope deviation or normalized slope deviation from one or more error parameters. The slope-adjusted correlation between analyte concentrations and output signals may be used to determine analyte concentrations having improved accuracy and/or precision from output signals including components attributable to bias. | 12-08-2011 |
| 20110297557 | Underfill Management System for a Biosensor - A biosensor system including the underfill management system determines the analyte concentration in a sample from the at least one analytic output signal value. The underfill management system includes an underfill recognition system and an underfill compensation system. The underfill recognition system determines whether the test sensor initially is substantially full-filled or underfilled, indicates when the sample volume is underfilled so that additional sample may be added to the test sensor, and starts or stops the sample analysis in response to the sample volume. The underfill recognition system also may determine the initial degree of underfill. After the underfill recognition system determines the initial fill state of the test sensor, the underfill compensation system compensates the analysis based on the initial fill state of the test sensor to improve the measurement performance of the biosensor system for initially underfilled test sensors. | 12-08-2011 |
| 20110297554 | Complex Index Functions - A biosensor system determines analyte concentration from an output signal generated from a light-identifiable species or a redox reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals or determined analyte concentrations with one or more complex index function extracted from the output signals or from other sources. The complex index functions determine at least one slope deviation value, ΔS, or normalized slope deviation from one or more error parameters. The slope-adjusted correlation between analyte concentrations and output signals may be used to determine analyte concentrations having improved accuracy and/or precision from output signals including components attributable to bias. | 12-08-2011 |
| 20110297540 | Low Total Salt Reagent Compositions and Systems for Biosensors - A biosensor system for determining the concentration of an analyte in a sample is disclosed that includes a reaction means for selectively performing a redox reaction of an analyte, and a measurement means for measuring a rate of the redox reaction of the analyte. The reaction means includes a binder, a buffer salt, a mediator including at most 20% (w/w) of an inorganic, non-transition metal salt, and an enzyme system. The measurement means includes at least two conductors. The measurement means measures an output signal value from the reaction means at a maximum kinetic performance within at most 7 seconds of introducing a sample to the reaction means, where the output signal value is responsive to the concentration of the analyte in the sample, and the measurement means determines at least one ΔS value responsive to at least one error parameter. The measurement means further determines the analyte concentration in the sample from a compensation equation including at least one reference correlation and the at least one ΔS value, where the compensation equation has a R | 12-08-2011 |
| 20110294959 | Polymer Bonded Redox Molecules And Methods Of Making The Same - A non-leaching mediator may include a polymer having a polymeric backbone, and a plurality of phenothiazine groups bonded to the polymeric backbone. The plurality of phenothiazine groups may include at least one of a phenothiazine group having the general formula (IV): | 12-01-2011 |
| 20110286988 | FVIII Muteins for Treatment of Von Willebrand Disease - This invention relates to treatment of von Willebrand Disease by administration of Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties in subjects lacking von Willebrand Factor. | 11-24-2011 |
| 20110281287 | SIZE SELF-LIMITING COMPOSITIONS AND TEST DEVICES FOR MEASURING ANALYTES IN BIOLOGICAL FLUIDS - A test strip or electrochemical sensor for measuring the amount of an analyte in a biological fluid, e.g. the glucose content of whole blood, includes a size self-limiting reagent formulation employing an enzyme system for reaction with the analyte, the reactive system mixed into a water-soluble swellable polymer matrix containing small water-insoluble particles having a nominal size of about 0.05 to 20 μm, preferably about 1 to 10 μm. The weight ratio of the water-insoluble particles to the water-soluble swellable polymer matrix is about 1/2 to 2/1. The reagent formulation is deposited onto a non-porous substrate to form a thin layer about 6-16 μm thick, providing a rapid and stable response to application of a sample, while being insensitive to the amount of the sample. | 11-17-2011 |
| 20110275121 | Methods and Compositions for Production of Recombinant Protein in HBX-Expressing Mammalian Cells - The method of the invention provides for producing a heterologous protein in mammalian host cells having nucleic acid encoding Hepatitis B X protein and the heterologous protein, by growing mammalian host cells selected from the group consisting of HKB11, CHO, BHK21, C2C12, and HEK293 cells, by growing mammalian host cells in non-adherent suspension culture, or by growing mammalian host cells which contain nucleic acid providing exogenous X-box Binding Protein, XBP1s. The conditions should be such that HBx, exogenous XBP1s if present, and the heterologous protein are expressed by the mammalian cells. The invention includes compositions for carrying out the method. | 11-10-2011 |
| 20110269147 | Methods, Devices, and Systems for Glycated Hemoglobin Analysis - Methods, devices, and systems for measuring the concentration of glycated hemoglobin (HbA | 11-03-2011 |
| 20110265548 | Underfill Detection System For A Biosensor - A biosensor has an underfill detection system that determines whether a sample of a biological fluid is large enough for an analysis of one or more analytes. The underfill detection system applies an excitation signal to the sample, which generates an output signal in response to the excitation signal. The underfill detection system switches the amplitude of the excitation signal. The transition of the excitation signal to a different amplitude changes the output signal when the sample is not large enough for an accurate and/or precise analysis. The underfill detection system measures and compares the output signal with one or more underfill thresholds to determine whether an underfill condition exists. | 11-03-2011 |
| 20110263597 | SUBSTITUTED PYRIDINES AND PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY - Methods of treating a mammal having a condition characterized by abnormal angiogenesis or hyperpermiability processes using substituted pyridazines having angiogenesis inhibiting activity and the generalized structural formula | 10-27-2011 |
| 20110263448 | Interferon Response in Clinical Samples (IRIS) - The present invention relates to a specific set of genes useful for determining the efficacy of a treatment against multiple sclerosis (MS). Further, the invention provides an array of these genes useful for evaluating efficacy of a MS treatment. Also provided are methods for evaluating efficacy of an MS treatment and a method for detecting neutralizing antibodies in patient response to interferonβ-1B treatment of MS. | 10-27-2011 |
| 20110262942 | OXIDIZABLE SPECIES AS AN INTERNAL REFERENCE IN CONTROL SOLUTIONS FOR BIOSENSORS - Testing of the performance of an electrochemical meter used to measure the presence of an analyte in a biological sample, particularly glucose in whole blood, includes introducing a control solution containing a predetermined amount of the analyte and a predetermined amount of an internal reference compound. The internal reference compound is selected such that it is oxidized at a potential greater than that used to oxidize the analyte, thereby making it possible to distinguish the control solution from a biological sample. | 10-27-2011 |
| 20110257035 | IDENTIFICATION OF SIGNATURE GENES ASSOCIATED WITH HEPATOCELLULAR CARCINOMA - The present invention relates to, for example, (1) a novel method for identification of clinically useful serum and/or tumor biomarkers and expression signatures that can be used for detection, prognostication and guidance for the treatment of patients with hepatocellular carcinoma (HCC); and (2) discovery of an expression signature that can be used to monitor and/or study the efficacy of a chemotherapeutic regimen, such as, for example, sorafenib (solely or in combination with other agents). The present invention also provides a method for predicting clinical outcomes, such as, for example, overall survival (OS), time to progression (TTP) and/or likelihood of benefitting from a chemotherapeutic treatment (i.e., sorafenib) in HCC patients based on the analysis of such biomarkers. | 10-20-2011 |
| 20110249265 | OPTICAL REAGENT FORMAT FOR SMALL SAMPLE VOLUMES - An optical waveguiding optical format enables consistent optical analysis of small sample volumes with minimal variation in light path length among optical formats. The optical format is comprised of an input guide, an output guide, and a sample cavity adapted to allow light to pass through a sample on its way from the input guide to the output guide. A lid removed from the light pathway within the format may be provided with a reagent for assisting fluid analysis. | 10-13-2011 |
| 20110247949 | Analyte Sensor Container Systems With Sensor Elevator and Storage Methods - An analyte sensor container system is provided for storing and dispensing analyte sensors. The analyte sensor container system includes a container body having a moveable member received therein. The moveable member may have one or more compartments with one or more analyte sensors supported thereon and a lid hinged to the container body. An elevator mechanism causes relative movement between the container body and moveable member upon opening and closing the lid. As such, the one or more analyte sensors are readily accessible to a user when the lid is opened, and retract into the container body upon lid closure. Methods of storing analyte sensors are provided as are numerous other aspects. | 10-13-2011 |
| 20110247944 | ELECTROCHEMICAL TEST SENSOR - An electrochemical test sensor for detecting the concentration of an analyte in a sample. The electrochemical test sensor comprises a base that provides a flow path for the fluid test sample having a counter electrode and a working electrode on its surface in electrical communication with a detector of electrical current. The electrochemical test sensor further includes a reagent layer directly located on the surface of the working electrode. The reagent layer includes an enzyme that is adapted to react with the analyte. The electrochemical test sensor further comprises a lid adapted to mate with the base and to assist in forming a capillary space with an opening for the introduction of the sample thereto. The capillary space is formed with a three-dimensional portion of the lid. | 10-13-2011 |
| 20110231105 | Residual Compensation Including Underfill Error - A biosensor system determines analyte concentration from an output signal generated from a light-identifiable species or a redox reaction of the analyte. The biosensor system compensates at least 50% of the total error in the output signal with a primary function and compensates a portion of the remaining error with a residual function. The amount of error compensation provided by the primary and residual functions may be adjusted with a weighing coefficient. The compensation method including a primary function and a residual function may be used to determine analyte concentrations having improved accuracy from output signals including components attributable to error. | 09-22-2011 |
| 20110226643 | Sealed Analyte Sensor Container Systems and Storage Methods - An analyte sensor container system is provided for storing and dispensing analyte sensors. The analyte sensor container system includes a container body having a plurality of compartments, each of the plurality of compartments including at least one analyte sensor, and a sealing member individually sealing each of the plurality of compartments. Methods of storing analyte sensors are provided as are numerous other aspects. | 09-22-2011 |
| 20110198487 | OPTICAL READHEAD AND METHOD OF USING THE SAME - A method of determining auto-calibrating information of a test sensor includes providing an optical read head that includes a light source, a light guide and a detector. The read head forms an opening that is sized to receive a test sensor. The detector includes a linear-detector array or single detector. A test sensor is provided having apertures formed therein. The test sensor is placed in the opening of the optical read head. Light is transmitted from the light source through the apertures. The light transmitted through the apertures using the detector or detecting the absence of light being transmitted through the test sensor using the detector is detected. The detected light or the absence of detected light information from the detector is used to determine the auto-calibration information of the test sensor. | 08-18-2011 |
| 20110191059 | Systems and Methods for Predicting Ambient Temperature in a Fluid Analyte Meter - A system for a meter configured to determine an analyte concentration of a fluid sample includes a housing and a temperature sensor disposed within the housing. The system also includes a processor configured to receive temperature data from the temperature sensor upon the meter entering one of a charge state and a discharge state. The processor is further configured to predict a temperature value that approximates the ambient temperature outside of the housing. The predicted temperature value is based on historical temperature data received from the temperature sensor such that the predicted temperature value remains constant if a recently received temperature value remains within predetermined upper and lower temperature thresholds and the recently received temperature value exceeds the at least one predicted temperature value. | 08-04-2011 |
| 20110184448 | LANCING DEVICE - A lancing device formed from a main body and a cap. The main body is configured from a lower housing, an upper housing extending over a portion of the lower housing, and an actuator operatively engaged to the upper and lower housings with the actuator extending along the portion of the lower housing not covered by the upper housing. The upper housing further includes an actuator button, wherein a lancet may be placed within the body such that movement of the actuator from a first position to a second position away from said endcap cocks the lancet for firing, which is achieved by depressing the actuator button. Conveniently, the lancing device is configured for tactile recognition in the palm of a human hand and may preferably be operated one handed and without visual observation. | 07-28-2011 |
| 20110180405 | Analyte Sensors, Systems, Testing Apparatus and Manufacturing Methods - In some aspects, an analyte sensor is provided for detecting an analyte concentration level in a bio-fluid sample. The analyte sensor may include one or more conductors received in a hollow portion of a hollow member. The first conductor may be made, at least in part, of a semiconductor material and an active region may be provided in contact with at least the first conductor. The analyte sensor may, in one aspect, include a lancet and an integrated sensor. Manufacturing methods and apparatus and systems utilizing the analyte sensors are provided, as are numerous other aspects. | 07-28-2011 |
| 20110175614 | METHODS OF IN-VITRO ANALYSIS USING TIME-DOMAIN NMR SPECTROSCOPY - An in vitro method of determining an analyte concentration of a sample includes placing the sample into a low-field, bench-top time-domain nuclear magnetic resonance (TD-NMR) spectrometer. The NMR spectrometer is tuned to measure a selected type of atom. A magnetic field is applied to the sample using a fixed, permanent magnet. At least one 90 degree radio-frequency pulse is applied to the sample. The radio-frequency pulse is generally perpendicular to the magnetic field. The 90 degree radio-frequency pulse is removed from the sample so as to produce a decaying NMR signal. The decaying NMR signal is measured at a plurality of times while applying a plurality of 180 degree refocusing radio-frequency pulses to the sample. The analyte concentration is calculated from the plurality of measurements associated with the decaying NMR signal and a selected model. | 07-21-2011 |
| 20110171071 | Analyte Sensors, Testing Apparatus and Manufacturing Methods - In some aspects, an analyte sensor is provided for detecting an analyte concentration level in a bio-fluid sample. The analyte sensor may include a first sensor member coupled to a base, wherein the first sensor member includes a semiconductor material, a second sensor member coupled to the base; and an active region in contact with at least the first sensor member. In some aspects, the first sensor member may be a fiber, and may have a conductive core and a semiconducting cladding surrounding the core. Manufacturing methods and apparatus utilizing the sensors are provided, as are numerous other aspects. | 07-14-2011 |
| 20110165685 | CONTAINERS FOR READING AND HANDLING DIAGNOSTIC REAGENTS AND METHODS OF USING THE SAME - A container with a rotatable lid for reading and handling diagnostic reagents in tape form comprising a body portion, a lid portion, a continuous tape, a reagent-sensing device, and a storage device. The body portion includes an inner and outer surface. The lid portion is attached to the body portion and is adapted to rotate from a closed position to an open position. The continuous tape includes a diagnostic reagent. The reagent-sensing device is attached to either the body portion or the lid portion and adapted to read the diagnostic reagent. The storage device is attached to the body portion that is adapted to hold and dispense an unused portion of the continuous tape. During the rotation of the lid portion, the continuous tape is advanced from the first storage device and is extended over the reagent-sensing device. | 07-07-2011 |
| 20110148905 | APPARATUS, SYSTEMS AND METHODS FOR DETERMINING AND DISPLAYING PRE-EVENT AND POST-EVENT ANALYTE CONCENTRATION LEVELS - Embodiments of the invention provide apparatus, systems and methods wherein pre-event and post-event analyte concentration readings associated with an event are collected and processed to determine a numerical delta. The numerical delta may be displayed on a visual display to aid in a ready determination of the affect that the event (alone or in combination with medication and/or insulin dosages) had on the analyte concentration levels. Medication and/or insulin dosages may be displayed alongside the numerical delta to gauge immediate relationships between numerical delta, dosage and/or an associated event. Apparatus and systems for calculating and displaying the numerical delta are described, as are other aspects. | 06-23-2011 |
| 20110144025 | Methods of Reducing Hemorrhage Due to Surgical Procedure - The invention concerns glycosylated proteins having human factor VIII activity. In a preferred embodiment, the protein is glycosylated with oligosaccharides that include an alpha-(2,6)-linked sialic acid and a bisecting GlcNAc linked to a core beta-mannose. | 06-16-2011 |
| 20110137571 | METER HAVING MULTI-LEVEL USER INTERFACE - A meter adapted to determine and store an analyte concentration reading, in particular a glucose concentration reading, and including an interface having a plurality of predefined levels of user features. The predefined levels may be selected by a user based on the user's preferences, needs and abilities. | 06-09-2011 |
| 20110115504 | Biosensor Methods Having Enhanced Stability and Hematocrit Performance - The present invention relates to electrochemical sensor strips and methods of determining the concentration of an analyte in a sample or improving the performance of a concentration determination. The electrochemical sensor strips may include at most 8 μg/mm | 05-19-2011 |
| 20110112022 | Factor VIII Muteins with Reduced Immonugenicity - The invention relates to modified Factor VIII molecules with reduced N-linked glycosylation and reduced immunogenicity. The invention also relates to methods of using modified Factor VIII molecules, for example, to treat patients afflicted with hemophilia. | 05-12-2011 |
| 20110108440 | Underfill Recognition System for a Biosensor - A biosensor with an underfill recognition system assesses whether to analyze a sample for one or more analytes in response to the volume of the sample. The underfill recognition system applies polling and test excitation signals to the sample. The polling signals generate one or more polling output signals, which maybe used to detect when a sample is present and to determine whether the sample has sufficient volume for analysis. The test excitation signal generates one or more test output signals, which may be used to determine one or more analyte concentrations in the sample. | 05-12-2011 |
| 20110102768 | METHOD OF DETERMINING GLUCOSE CONCENTRATION OF A WHOLE BLOOD SAMPLE - A total transmission spectroscopy system for use in determining the analyte concentration in a fluid sample comprises a sample cell receiving area, a light source, a collimating lens, a first lens, a second lens, and a detector. The sample cell receiving area is adapted to receive a sample to be analyzed. The sample cell receiving area is constructed of a substantially optically clear material. The collimating lens is adapted to receive light from the light source and adapted to illuminate the sample cell receiving area with a substantially collimated beam of light. The first lens is adapted to receive regular and scattered light transmitted through the sample at a first angle of divergence. The first lens receives light having a first angle of acceptance. The first lens outputs light having a second angle of divergence. The second angle of divergence is less than the first angle of divergence. The second lens is adapted to receive light from the first lens and adapted to output a substantially collimated beam of light. The detector is adapted to measure the light output by the second lens. | 05-05-2011 |
| 20110098301 | Pyrimidine Derivatives for Treatment of Hyperproliferative Disorders - Pyrimidine derivatives of formula | 04-28-2011 |
| 20110097808 | Sensor-Dispensing Instruments - A sensor-dispensing instrument is adapted to determine an analyte concentration of a fluid and comprises a body, a cap, a cartridge, a test-sensor receptacle, and a sensor-advancement mechanism. The cap is adapted to move between an open position and a closed position. The cap and body are adapted to correspond with each other to form the closed position. The cartridge contains a plurality of test sensors. The cartridge is located substantially within the cap. The sensor-advancement mechanism is adapted to advance the plurality of test sensors, one at a time, to a position that allows a user to manually remove the test sensor and place the test sensor in the test-sensor receptacle. The sensor-dispensing instrument may also include a lancing device including a lancet. | 04-28-2011 |
| 20110091357 | ANALYTICAL SYSTEMS, DEVICES, AND CARTRIDGES THEREFOR - Described here are systems, devices, cartridges, methods, and kits for detecting or quantifying at least two different analytes using at least two different techniques, in a single sample. The cartridges typically comprise at least two test sites and the location of at least one test site is not dependent on a corresponding measurement device. The systems generally comprise a device, memory, and a processing module. The device comprises a light source, an array detector, and a port configured to accept at least a portion of a cartridge. The processing module is configured to perform an image analysis of the cartridge. The methods comprise the steps of acquiring calibration information, acquiring an image of the cartridge, performing an image analysis, and cycling through specific detection or quantification techniques corresponding to the techniques required by the test sites. Computer readable media are also described. | 04-21-2011 |
| 20110077202 | Targeted Coagulation Factors and Method of Using the Same - Targeted coagulation factors comprising a coagulation factor linked with at least one domain that specifically binds to a membrane protein on a blood cell is provided. The disclosed targeted coagulation factors increase the efficiency of coagulation factors and prolong their duration of action and thus, are an improvement for the treatment of hematological diseases such as hemophilia A. | 03-31-2011 |
| 20110073476 | Stackable Electrochemical Analyte Sensors, Systems and Methods Including Same - In some aspects, an analyte sensor is provided for detecting an analyte concentration level in a bio-fluid sample. The analyte sensor has a base with first and second ends, a concave recess in the first end, a second end receiving surface, and a sidewall extending between the ends. An electrode may be provided on the receiving surface with an electrochemically-active region coupled to the electrode. A conductor in electrical contact with the electrode may extend along the sidewall and may be adapted to be in electrical contact with a first contact of an analyte meter. Manufacturing methods and systems utilizing and dispensing the analyte sensors are provided, as are numerous other aspects. | 03-31-2011 |
| 20110061458 | Methods Of Using An Electrochemical Biosensor - According to one embodiment of the present invention, an electrochemical sensor ( | 03-17-2011 |
| 20110056848 | ELECTROCHEMICAL TEST SENSOR - An electrochemical test sensor for detecting the concentration of an analyte in a fluid sample. The electrochemical test sensor includes a housing that has a first end and a second opposing end. The housing includes an opening at the first end to receive a fluid test sample. An electrode assembly includes a substrate, a working electrode, a counter electrode and a reagent. The substrate has a first surface and an opposing second surface. The working electrode is disposed on the first surface of the substrate, and the counter electrode is disposed on the second surface of the substrate. The electrode assembly is positioned within the housing to define a reaction channel. The electrochemical test sensor may be used with a removable lancet mechanism or integrated within a lancet mechanism to form one integral unit. | 03-10-2011 |
| 20110040163 | ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY ENABLED CONTINUOUS GLUCOSE MONITORING SENSOR SYSTEMS - The use of electrical impedance spectroscopy to adjust calibration settings in an in vivo monitoring system, such as an in vivo continuous glucose monitoring sensor. The adjustments can compensate for the condition of the sensor membrane in vivo. | 02-17-2011 |
| 20110039295 | DISPLAY WITH ICONIC MARKERS FOR A METER - Meters, methods, and computer-readable media for determining the concentration of an analyte in a fluid sample are presented herein. One concept is directed to a meter for determining the concentration of an analyte in a fluid sample. The meter includes a housing configured to receive a test sensor carrying the fluid sample, and a processor configured to determine analyte concentration information from the fluid sample. A memory is coupled to the processor and configured to store the analyte concentration information. A display is coupled to the housing and configured to display the analyte concentration information and one or more iconic markers. Each iconic marker represents a respective state of the user. Each user state has a known affect on the analyte concentration information. An input device is coupled to the processor and configured to receive the user's selection from the iconic markers. The user's selection is stored by the memory. | 02-17-2011 |
| 20110039286 | Temperature-Adjusted Analyte Determination For Biosensor System - A biosensor system determines analyte concentration from an output signal generated by an oxidation/reduction reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals at one temperature to determining analyte concentrations from output signals at other temperatures. The temperature-adjusted correlation between analyte concentrations and output signals at a reference temperature may be used to determine analyte concentrations from output signals at a sample temperature. | 02-17-2011 |
| 20110021518 | PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING CANCER THROUGH INHIBITION OF AURORA KINASE - This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly Cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly Cancer. | 01-27-2011 |
| 20110011151 | Auto-Calibration Circuit For Analyte Measurement - Embodiments provide expanded ability to communicate calibration information to diagnostic systems for determining a characteristic of a test sample. An example system for determining a characteristic of a test sample includes: a test sensor for receiving a test sample; a sensor meter responsive to the test sensor, the sensor meter determining a characteristic of the test sample received on the test sensor; and a calibration element including electrical contacts readable by the sensor meter. The electrical contacts are configurable in one of a plurality of patterns that communicates, to the sensor meter, information relating to the determination of the characteristic of the test sample. The plurality of patterns include two or more of the electrical contacts that are electrically isolated from any other electrical contacts. The sensor meter determines at least partially the information from the electrical contacts by determining a combination of values corresponding to the isolated electrical contacts. | 01-20-2011 |
| 20110008768 | OLIGONUCLEOTIDES AND METHODS FOR DETECTION OF WEST NILE VIRUS - The invention provides methods of detecting West Nile virus and oligonucleotide reagents derived from a West Nile virus consensus sequence that are useful in the methods of the invention. | 01-13-2011 |
| 20100329951 | Test Sensor Package - A fluid sensor comprises a formed plastic body and a reagent. The body has a top face with an integral first surface. The body also has a bottom face opposed to the first surface and a sidewall that extends from the periphery of the top face. The first surface is adapted to accept a fluid sample. The reagent is disposed on the integral first surface and causes a color change detectable on the bottom face when the reagent reacts with an analyte in the fluid sample. | 12-30-2010 |
| 20100319436 | System and Apparatus for Determining Temperatures in a Fluid Analyte System - A test sensor includes a body, a first conductive trace, a second conductive trace, and a third conductive trace. The body includes a first region that has a fluid-receiving area, a second region separate from the first region, and a first temperature sensing interface disposed at or adjacent to the fluid-receiving area. The fluid-receiving area receives a sample. The first trace is disposed on the body, and at least a portion of the first trace is disposed in the first region. The second and third traces are disposed on the body. The third trace extends from the first to the second regions. The third trace is connected to the first trace at the first temperature sensing interface. The third trace includes a different material than the first trace. A first thermocouple is formed at the first temperature sensing interface. The thermocouple provides temperature data to determine an analyte concentration. | 12-23-2010 |
| 20100309947 | METHOD AND ASSEMBLY FOR DETERMINING THE TEMPERATURE OF A TEST SENSOR - Methods and systems accurately determine an analyte concentration in a fluid sample. In an example embodiment, a receiving port receives a test sensor. The test sensor includes a fluid-receiving area for receiving a fluid sample. The fluid-receiving area contains a reagent that produces a measurable reaction with an analyte in the fluid sample. The test sensor has a test-sensor temperature and the reagent has a reagent temperature. A measurement system measures the reaction between the reagent and the analyte. A temperature-measuring system measures the test sensor temperature when the test sensor is received into the receiving port. A concentration of the analyte in the fluid sample is determined according to the measurement of the reaction and the measurement of the test sensor temperature. A diagnostic system determines an accuracy of the temperature-measuring system. The calculation of the analyte concentration may be adjusted according to the accuracy of temperature-measuring system. | 12-09-2010 |
| 20100300896 | Redox Molecules And Methods Of Making The Same - A non-leaching mediator may include a compound having the general formula (I): | 12-02-2010 |
| 20100299075 | SYSTEMS AND METHODS FOR CALCULATING AN AVERAGE ANALYTE CONCENTRATION VALUE - Embodiments provide methods and systems wherein analyte concentration readings taken over a first period of time are collected and processed to determine one or more analyte concentration averages. The methods include collecting samples with a measurement system (e.g., a Blood Glucose Meter) over a first period of time, dividing the first period of time into smaller time increments, and calculating an average analyte concentration based on first sub-averages obtained from each of the smaller time increments. Systems for carrying out the analyte concentration averages are described, as are other aspects. | 11-25-2010 |
| 20100298679 | SEMICONDUCTOR BASED ANALYTE SENSORS AND METHODS - An analyte sensor is provided that comprises a substrate which includes a semiconductor material. Embodiments may include a core of a conductive material, and a cladding of a semiconductor material, in which the cladding may form at least a portion of a conducting path for a working electrode of the analyte sensor. Method of manufacturing and using the analyte sensor are described, as are numerous other aspects. | 11-25-2010 |
| 20100288841 | CALIBRATION CODED SENSORS AND APPARATUS, SYSTEMS AND METHODS FOR READING SAME - In some aspects, a colored coded analyte sensor is provided. The analyte sensor has a body and a plurality of machine-readable colored codes associated with the body. The colored codes may contain red, green, and blue hues, which are discernable into coded information. The coded information may include the analyte sensor model, analyte sensor calibration constant, expiration or manufacture date of the analyte sensor, analyte sensor counterfeiting codes, warnings, messages to the user, etc. Colored code reading systems, apparatus and methods for reading such color-coded information associated with the analyte sensor are provided, as are numerous other aspects. | 11-18-2010 |
