ALBERT-LUDWIGS-UNIVERSITAET FREIBURG Patent applications |
Patent application number | Title | Published |
20140303030 | METHOD FOR IDENTIFYING APTAMERS - The invention relates to a method for identifying aptamers, having the following steps bringing a mixture of oligonucleotides into contact with an aptamer target structure and binding at least some of the oligonucleotides to the target structure, separating the oligonucleotides which have been bound to the aptamer target structure from the aptamer target structure and from oligonucleotides that are not bound to the aptamer target structure, amplifying individual oligonucleotides which were bound to the aptamer target structure in a physically separate manner and producing a plurality of physically separate amplicons, each amplicon predominantly containing one type of oligonucleotides, specifying a specific marker for a plurality of the physically separate amplicons such that each of the marked amplicons can be uniquely identified using the specified marker of the amplicon, sequencing oligonucleotides in a plurality of marked amplicons and assigning the marker that is specific for the amplicon to the sequence of the type of oligonucleotides in the amplicon for each amplicon examined by means of the sequencing process analyzing the binding properties of the types of oligonucleotides to the aptamer target structure and assigning the analyzed binding properties to the specific markers of the amplicons and to the sequences of the types of oligonucleotides. | 10-09-2014 |
20140300352 | METHOD TO ENTER MAGNETIC RESONANCE DATA INTO A MEMORY ORGANIZED AS k-SPACE, AND MAGNETIC RESONANCE APPARATUS OPERATING ACCORDING TO THE METHOD - In a method to associate k-space lines with echo trains of raw magnetic resonance data, parallel k-space lines orthogonally intersect a plane at respective intersection points. Each echo train has a trajectory length, and the k-space lines are associated with the echo trains such that a sum of trajectory lengths of all echo trains is minimal. The trajectory length TL of an echo train is defined by | 10-09-2014 |
20140112973 | BIOCOMPATIBLE AND BIODEGRADABLE GRADIENT LAYER SYSTEM FOR REGENERATIVE MEDICINE AND FOR TISSUE SUPPORT - The present invention is directed to a biocompatible and preferably biodegradable gradient layer system comprising at least one set of layers comprising a biocompatible and preferably biodegradable cross-linked polymer and at least one biocompatible and preferably biodegradable support layer, wherein a gradient is preferably formed with respect to the mechanical and/or physical properties of one or more layers of the at least one set of layers comprising a biocompatible and biodegradable cross-linked polymer and/or the at least one biocompatible and preferably biodegradable support layer. The at least one support layer preferably comprises a biocompatible and preferably biodegradable meltable polymer and/or a biocompatible and incorporable material. This biocompatible and preferably biodegradable gradient layer system may be used as a biomaterial for regenerative medicine, particularly as a wound dressing or for tissue support. The present invention also provides means utilizing said inventive gradient layer system and methods for producing same. | 04-24-2014 |
20140062503 | Microstructure Device for Measuring Molecular Membranes and a Method for Producing Said Microstructure Device - The invention is related to a microstructure apparatus for the measurement of biological membranes, comprising a support substrate having an upper side for supporting the membrane, at least one microcavity of the support substrate for receiving an electrolyte, wherein the microcavity is open upward and ends in a microaperture in the upper side of the support substrate, wherein the microaperture has a first characteristic diameter D1 and has at least one electrode, which is at least partially arranged within the microcavity and which has a contact side for contacting an electrolyte, the contact side being arranged adjacent to the inner volume of the microcavity, characterized in that the contact side of the electrode has a characteristic diameter D2, being larger than D1. The invention further relates to a corresponding method for producing the microstructure apparatus. | 03-06-2014 |
20140044866 | Method for the Automated Production Consisting of a Molecular Layer of Amphiphilic Molecules and a Device for Producing Said Molecular Layer - The invention is related to a method and an apparatus for the automated fabrication of a molecular layer made from amphiphilic molecules, in particular lipids for a lipid bilayer membrane, in the apparatus, which has a support substrate for supporting the molecular layer, a rotation element, which can be rotated on top of the support substrate, and an actuator device, by means of which the rotation element can be automatically rotated, wherein the rotation element has an outer surface, which is formed hydrophobic at least in sections, the method having the following steps: placing a first solvent, which contains amphiphilic molecules, in a region above the support substrate; causing the automatic rotation of the rotation element above the support substrate; moving the first solvent between the support substrate and the rotation element by the interaction of the rotating rotation element with the first solvent, thus forming the molecular layer. | 02-13-2014 |
20140038854 | DEVICE AND METHOD FOR THE GENERATION OF MOLECULAR MICROARRAYS - The invention relates to a device and a method for the generation of molecular microarrays. The invention relates therefore to a universal approach for the generation of protein microarrays, DNA microarrays and RNA microarrays (in general nucleic acid microarrays), by production of an output molecule from a template molecule microarray via enzymatic or chemical processes and transfer of the output molecule onto the desired molecular microarray. | 02-06-2014 |
20130338326 | COVALENTLY ATTACHED ANTIMICROBIAL POLYMERS - The present invention relates to substrates comprising covalently attached antimicrobial polymers, which act as synthetic mimics of antimicrobial peptides (SMAMPs) and are preferably obtained by ring opening metathesis polymerization (ROMP). The inventive antimicrobial polymers exhibit a molecular weight of more than 100,000 g mol | 12-19-2013 |
20130330717 | METHOD FOR INTRODUCING A POLYNUCLEOTIDE INTO NON-ADHESIVELY GROWING PLANT CELLS - The present invention relates to a method for introducing a polynucleotide into non-adhesively growing plant cells, comprising the following steps: providing a solid support having immobilized thereto the polynucleotide in dry state; contacting the plant cells with the polynucleotide on the solid support so as to obtain transformed plant cells; and optionally washing the plant cells. | 12-12-2013 |
20130315996 | BIO-FUNCTIONALIZED STIMULUS-RESPONSIVE DISSOLVABLE PEG-HYDROGELS - The present invention is directed to a bio-functionalized stimulus-responsive dissolvable PEG-hydrogel. This inventive stimulus-responsive dissolvable PEG-hydrogel comprises a matrix of PEG-polymers, which are modified to contain at least one multifunctional fusion protein, the multifunctional fusion protein preferably comprising as components a substrate binding peptide (SBP), preferably a repetitive RGD-binding peptide and/or a ZZ-binding domain, preferably a tag for purification, and at least one N- and/or C-terminal linker. The present invention is furthermore directed to the use of such inventive stimulus-responsive dissolvable PEG-hydrogels in the treatment of lesions, in surgical dressings, for wound treating, for soft and hard tissue regeneration, for the treatment of wounds in the oral cavity, in the field of ophthalmology, in the field of periodontal defects, etc. The invention also describes a method of treatment for such diseases. Additionally, the present invention provides a kit comprising the inventive stimulus-responsive dissolvable PEG-hydrogel and optionally further components. | 11-28-2013 |
20130134317 | DETECTOR AND METHOD FOR DETECTING IONIZING RADIATION - A detector and a method for the detection of ionising radiation are proposed. The detector ( | 05-30-2013 |
20130095469 | APPARATUS AND METHOD FOR DISPENSING CELLS OR PARTICLES CONFINED IN A FREE FLYING DROPLET - An apparatus for dispensing one or more cells or particles confined in a free flying droplet has a droplet generating device configured to eject out of an orifice a free flying droplet of a suspension of cells or particles. The droplet generating device has a branch-less one-way channel having the orifice at one end thereof. A device for detecting information on cells or particles located in an observation volume of the suspension within the branch-less one-way channel is provided. An ejected droplet is directed to a first position or a second position depending on the detected information. | 04-18-2013 |
20130068156 | METHOD FOR GROWING II-VI SEMICONDUCTOR CRYSTALS AND II-VI SEMICONDUCTOR LAYERS - A method for growing II-VI semiconductor crystals and II-VI semiconductor layers as well as crystals and layers of their ternary or quaternary compounds from the liquid or gas phase is proposed. To this end, the solid starting materials are introduced into a growing chamber for the growing of crystals. Inside the growing chamber, carbon monoxide is supplied by way of reducing agent. At least certain zones of the growing chamber are heated to a temperature at which a first-order phase transition of the starting materials takes place and the starting materials pass into the liquid or gas phase. The starting materials are then cooled down accompanied by the formation of a semiconductor crystal or semiconductor layer, again with a first-order phase transition taking place. The oxygen present in the growing chamber is bound by the carbon monoxide and the formation of an oxide layer at the phase boundary of the growing semiconductor crystal or semiconductor layer is prevented. | 03-21-2013 |
20120314528 | DEVICE, FLUIDIC MODULE AND METHOD FOR PRODUCING A DILUTION SERIES - A device for producing a dilution series from a solution to be diluted, which contains a substance to be diluted, and a dilution solution, includes a body of rotation, a drive configured to subject the body of rotation to rotations having different rotation protocols, and a controller configured to control the drive so as to subject the body of rotation to the different rotational frequencies. A first mixing chamber and a second mixing chamber are connected via a fluidic connection which enables producing, in the first mixing chamber, a first mixture having a first dilution ratio, transferring a partial volume of the first mixture into the second mixing chamber, and there producing a second mixture having a second dilution ratio. | 12-13-2012 |
20120015844 | DEVICE AND METHOD FOR PRODUCING A REPLICATE OR DERIVATIVE FROM AN ARRAY OF MOLECULES, AND APPLICATIONS THEREOF - A method of producing a replicate or derivative of an array of molecules, the array having a spatial arrangement of separate samples of molecules, includes creating, for each sample, at least one spatially limited effective area which is separate from the effective areas of the other samples, a surface, provided with a binding adapter or binding properties, of a carrier bordering on the effective areas. The molecules are amplified by means of amplifying agents in the effective areas for creating replicates or derivatives of the samples. The replicates or derivatives of the samples are bound to the carrier by means of the binding adapter or the binding properties, so that a spatial arrangement of the replicates or derivatives of the samples on the carrier corresponds to the spatial arrangement of the samples in the array. The carrier having the copies of the samples is removed from the array. | 01-19-2012 |
20100307584 | SOLAR ELEMENT WITH INCREASED EFFICIENCY AND METHOD FOR INCREASING EFFICIENCY - A solar element with increased efficiency and also a method for increasing the efficiency of a solar cell are provided. The solar cell comprises a luminescent element, an upconverter, and also at least one selectively reflecting structure. | 12-09-2010 |
20100160940 | Surgical Instrument - A surgical instrument has a shaft, an end effector comprising at least one movably mounted tool element and defining a longitudinal axis, and a force transmitting member mounted in the shaft for movement in the distal and proximal directions for transmitting an actuating force introduced at a proximal end of the instrument onto the end effector in order to move the at least one tool element from a first tool element position to a second tool element position and/or vice versa. The at least one tool element is pivotably mounted on a bearing shaft held on the shaft. The at least one tool element is connected by at least one articulation member, at least a section of which is flexible, to the force transmitting member in order to transmit the actuating force from the force transmitting member onto the at least one tool element. | 06-24-2010 |