Patent application title: METHODS OF REDUCING EXPRESSION OF X-INACTIVATION ESCAPEE GENES AND AUTOSOMAL GENES
Inventors:
IPC8 Class: AC12N15113FI
USPC Class:
1 1
Class name:
Publication date: 2020-04-09
Patent application number: 20200109402
Abstract:
Inhibitory nucleic acids, e.g., antisense oligonucleotides (ASO) against
PAR-TERRA RNA or other chromosome-specific TERRA transcripts (i.e.,
inclusive of chromosome-specific subtelomeric sequences), and methods of
use thereof to downregulate expression of escapee genes on the inactive X
chromosome, expression from the active X chromosome, subtelomeric
autosomal loci (e.g., FSHD locus), or expression of autosomal genes
involved in growth control and apoptosis, e.g., in cells and subjects
with supernumerary X chromosomes and/or cancer and other human diseases.Claims:
1. A composition comprising an isolated inhibitory nucleic acid targeting
PAR-TERRA, preferably wherein the inhibitory nucleic acid is modified.
2. A method of decreasing expression of an Xi escapee gene in a cell, preferably a cell of a subject have a supernumerary X chromosome, the method comprising administering to the cell an inhibitory nucleic acid targeting PAR-TERRA, preferably wherein the inhibitory nucleic acid is modified.
3. A method of decreasing expression of Xa genes in a cell, preferably a cell of a subject having a supernumerary X chromosome, the method comprising administering to the cell an inhibitory nucleic acid targeting PAR-TERRA, preferably wherein the inhibitory nucleic acid is modified.
4. A method of treating a subject who has a disorder of sex chromosome aneuploidy associated with a supernumerary X chromosome, the method comprising administering to the subject an inhibitory nucleic acid targeting PAR-TERRA, preferably wherein the inhibitory nucleic acid is modified.
5. A method of decreasing expression of autosomal genes in a cell, the method comprising administering to the cell an inhibitory nucleic acid targeting PAR-TERRA or an autosome-specific TERRA, preferably TERRA species originating within the subtelomeric region of an autosome and comprising autosome-specific 5' sequences, preferably wherein the inhibitory nucleic acid is modified.
6. The method of claim 5, wherein the inhibitory nucleic acid targets Chr4-specific TERRA.
7. The method of claim 6, wherein expression of FRG1, FRG2, DUX4, and the long noncoding RNAs of forward and reverse orientations from the macrosatellite repeat, D4Z4, is decreased.
8. The method of claims 6-7, wherein the cell is from or in a subjection who has facioscapulohumeral muscular dystrophy (FSHD).
9. The composition of claim 1, for treating a subject who has a disorder of sex chromosome aneuploidy associated with a supernumerary X chromosome.
10. The composition or methods of claim 4 or 9, wherein the subject has 46,XY, 47,XXY, 48,XXYY, 48,XXXY, 47,XXX, 48,XXXX or 49,XXXXX aneuploidy.
11. The method of claim 2, wherein the cell is from a subject who has 46,XY, 47,XXY, 48,XXYY, 48,XXXY, 47,XXX, 48,XXXX or 49,XXXXX aneuploidy.
12. A method of decreasing expression of X-linked or autosomal growth control or apoptosis genes in a cell, the method comprising administering to the cell an inhibitory nucleic acid targeting PAR-TERRA, PAR, or TERRA, preferably wherein the inhibitory nucleic acid is modified.
13. The composition or method of claim 1-7, 9, 11 or 12, wherein the inhibitory nucleic acid does not comprise three or more consecutive guanosine nucleotides or does not comprise four or more consecutive guanosine nucleotides.
14. The composition or method of claimsl-7, 9, 11 or 12, wherein the inhibitory nucleic acid is 8 to 30 nucleotides in length.
15. The composition or method of claim 1-7, 9, 11 or 12, wherein at least one nucleotide of the inhibitory nucleic acid is a nucleotide analogue.
16. The composition or method of claimsl-7, 9, 11 or 12, wherein at least one nucleotide of the inhibitory nucleic acid comprises a 2' O-methyl, e.g., wherein each nucleotide of the inhibitory nucleic acid comprises a 2' O-methyl.
17. The composition or method of claimsl-7, 9, 11 or 12, wherein the inhibitory nucleic acid comprises at least one ribonucleotide, at least one deoxyribonucleotide, or at least one bridged nucleotide.
18. The composition or method of claim 17, wherein the bridged nucleotide is a LNA nucleotide, a cEt nucleotide or a ENA modified nucleotide.
19. The composition or method of claim 1-7, 9, 11, or 12, wherein each nucleotide of the inhibitory nucleic acid is a LNA nucleotide.
20. The composition or method of claim 19, wherein one or more of the nucleotides of the inhibitory nucleic acid comprise 2'-fluoro-deoxyribonucleotides and/or 2'-O-methyl nucleotides.
21. The composition or method of claimsl-7, 9, 11, or 12, wherein one or more of the nucleotides of the inhibitory nucleic acid comprise one of both of ENA nucleotide analogues or LNA nucleotides.
22. The composition or method of claimsl-7, 9, 11, or 12, wherein the nucleotides of the inhibitory nucleic acid comprise comprising phosphorothioate internucleotide linkages between at least two nucleotides, or between all nucleotides.
23. The method or compositions of claimsl-7, 9, 11, or 12, wherein the inhibitory nucleic acid is a gapmer or a mixmer.
Description:
CLAIM OF PRIORITY
[0001] This application is a continuation of U.S. patent application Ser. No. 15/780,509, filed May 31, 2018, which is a .sctn. 371 National Stage Application of PCT/US2016/064438, filed Dec. 1, 2016, which claims the benefit of U.S. Provisional Patent Application Ser. No. 62/261,698, filed on Dec. 1, 2015. The entire contents of each of the foregoing are hereby incorporated by reference.
TECHNICAL FIELD
[0003] Described herein are inhibitory nucleic acids, e.g., antisense oligonucleotides (ASO) against PAR-TERRA RNA and TERRA of autosomal origin, and methods of use thereof to downregulate: (i) expression of escapee genes on the inactive X chromosome (Xi), e.g., in cells and subjects with supernumerary X chromosomes, (ii) expression from the active X chromosome (Xa), (iii) expression a network of autosomal genes involved in growth control and apoptosis, and (iv) expression of the genetic locus associated with FSHD (facioscapulohumeral muscular dystrophy) and other subtelomeric autosomal genes.
BACKGROUND
[0004] The mammalian genome is ubiquitously transcribed and the ends of telomeres are no exception. In spite of their heterochromatic properties, telomeric ends actively synthesize a heterogeneous population of long noncoding RNAs dubbed "TERRA" (Azzalin et al., 2007; Schoeflner and Blasco, 2007; Zhang et al., 2009). TERRA transcripts range in size from 100 bases up to >9 kb and contain the canonical telomeric repeat sequence, UUAGGG as well as sequences unique to the sub-telomeric region of each chromosome. The function of TERRA has generated major interest in light of its association with human diseases, such as cancer and the ICF syndrome (immunodeficiency, centromere instability, and facial anomalies)(Maicher et al., 2012; Azzalin and Lingner, 2015). Elegant studies have pointed to a number of telomere-associated functions. Telomeres are well-defined nucleoprotein complexes that cap the physical ends of linear chromosomes and protect them from unprogrammed shortening and genetic rearrangements (Blackburn et al., 2006; Sfeir and de Lange, 2012; Bernardes de Jesus and Blasco, 2013; Doksani and de Lange, 2014; Azzalin and Lingner, 2015). The reverse transcriptase activity of the RNA-containing telomerase complex enables regeneration of chromosomal ends that are lost with every DNA replication (Lingner et al., 1997). However, TERRA's activity does not appear to be directly related to telomerase activity (Schoeftner and Blasco, 2007; Redon et al., 2010; Redon et al., 2013). Rather, TERRA seems to keep telomere length in check (Sandell et al., 1994; Luke et al., 2008; Maicher et al., 2012; Pfeiffer and Lingner, 2012; Pfeiffer et al., 2013; Wang et al., 2015), regulate recombination (Balk et al., 2013; de Silanes et al., 2014; Yu et al., 2014), and serve as a scaffold for recruitment of HP1, histone methyltransferases, and shelterins to telomeric heterochromatin (Deng et al., 2009). Thus, TERRA is an integral part of the telomeric architecture.
[0005] Cytological studies indicate that only about half of detectable TERRA transcripts are localized to telomeres (Le et al., 2013). The remaining half is presumed to be "free" in the nucleoplasm. Nevertheless, investigation into TERRA function has focused almost exclusively on telomeres, though early observations noted a large cluster of TERRA transcripts near the inactive X-chromosome (Xi) of somatic female cells (Schoeftner and Blasco, 2008; Zhang et al., 2009). TERRA RNA is also concentrated next to the Y-chromosome (Zhang et al., 2009).
SUMMARY
[0006] Telomeric repeat-containing RNAs (TERRA) are highly conserved long non-coding RNAs transcribed from telomeric ends of eukaryotic chromosomes. TERRA has so far only been ascribed function in telomere biology. Genome-wide binding sites for TERRA have now been identified, and show that TERRA localization is not cis-limited, nor is TERRA function confined to telomeres. Transcriptomic analysis shows that TERRA depletion results in dysregulation of TERRA target genes. Described herein is a subclass of TERRA transcripts specific to the sex chromosomes. Dubbed PAR-TERRA, these transcripts originate within the pseudoautosomal region (PAR) and mediate two special sex-linked processes. First, in somatic cells, PAR-TERRA prevents spreading of Xist RNA away into genes that escape silencing on the inactive X (Xi). PAR-TERRA renders X-linked escapee genes immune to Xist RNA. Depleting PAR-TERRA leads to downregulation of escapees. We also show that depleting PAR-TERRA reduces expression of the Xa gene and various target autosomal genes, especially those involved in apoptosis and cell cycle regulation. Thus, the methods can also be applied to downregulate a network of autosomal genes involved in growth control and apoptosis. Provided herein is evidence that PAR-TERRA sets up a specialized privileged compartment that aids in boosting transcriptional activity specific genes across the genome. Thus, PAR-TERRA may be targeted to turn down (i) expression of escapee genes on the inactive X chromosome (Xi), e.g., in cells and subjects with supernumerary X chromosomes, (ii) expression from the active X chromosome (Xa), or (iii) expression a network of autosomal genes involved in growth control and apoptosis. The present methods include using inhibitory nucleic acids, e.g., antisense oligonucleotides (ASO) against PAR-TERRA RNA to downregulate expression of these classes of genes.
[0007] Thus, provided herein are isolated inhibitory nucleic acids targeting PAR-TERRA, preferably wherein the inhibitory nucleic acid is modified, and compositions comprising the isolated nucleic acids.
[0008] Also provided are methods for decreasing expression of an Xi escapee gene in a cell, preferably a cell of a subject have a supernumerary X chromosome. The methods include administering to the cell an inhibitory nucleic acid targeting PAR-TERRA, preferably wherein the inhibitory nucleic acid is modified.
[0009] Further, provided are methods for decreasing expression of Xa genes in a cell, preferably a cell of a subject having a supernumerary X chromosome. The methods include administering to the cell an inhibitory nucleic acid targeting PAR-TERRA, preferably wherein the inhibitory nucleic acid is modified.
[0010] Also provided are methods for treating a subject who has a disorder of sex chromosome aneuploidy associated with a supernumerary X chromosome. The methods include administering to the subject an inhibitory nucleic acid targeting PAR-TERRA, preferably wherein the inhibitory nucleic acid is modified.
[0011] Also provided is a composition described herein, e.g., comprising an inhibitory nucleic acid targeting PAR-TERRA, for treating a subject who has a disorder of sex chromosome aneuploidy associated with a supernumerary X chromosome.
[0012] In some embodiments described herein, the subject has 46,XY, 47,XXY, 48,XXYY, 48,XXXY, 47,XXX, 48,XXXX or 49,XXXXX aneuploidy.
[0013] In some embodiments described herein, the cell is from a subject who has 46,XY, 47,XXY, 48,XXYY, 48,XXXY, 47,XXX, 48,XXXX or 49,XXXXX aneuploidy.
[0014] Also provided are methods for decreasing expression of X-linked, autosomal growth control or apoptosis genes, and sub-telomeric autosomal genes in a cell (e.g., out D4Z4, DUX4, FRG1, and FRG2 for FSHD, from Chr4). The methods include administering to the cell an inhibitory nucleic acid targeting PAR-TERRA, PAR, or TERRA, preferably wherein the inhibitory nucleic acid is modified.
[0015] In addition, provided are methods for decreasing expression of autosomal genes in a cell. The methods include administering to the cell an inhibitory nucleic acid targeting PAR-TERRA or an autosome-specific TERRA (e.g., TERRA species originating with the subtelomeric region of an autosome and comprising autosome-specific 5' sequences), preferably wherein the inhibitory nucleic acid is modified. In some embodiments, the inhibitory nucleic acid targets Chr4-specific TERRA. In some embodiments, expression of FRG1, FRG2, DUX4, and the long noncoding RNAs of forward and reverse orientations from the macrosatellite repeat, D4Z4 is decreased. In some embodiments, the cell is from or in a subjection who has facioscapulohumeral muscular dystrophy (FSHD). Thus, in a specific example the methods include targeting the Chr4 region associated with facioscapulohumeral muscular dystrophy (FSHD), which is located in the subtelomeric region of human Chr4 and contains coding genes FRG1, FRG2, DUX4, and the long noncoding RNAs of forward and reverse orientations from the macrosatellite repeat, D4Z4. FSHD is caused by ectopic expression of these genes when the D4Z4 repeat contracts and becomes "activated". Thus, PAR-TERRA or Chr4-specific TERRA can be targeted to downregulated the associated subtelomeric genes. Other subtelomeric genes, e.g., as shown in FIG. 4A,B, from 5 chromosomes are shown (Chr1,3,8,18,19), can also be targeted.
[0016] In some embodiments described herein, the inhibitory nucleic acid does not comprise three or more consecutive guanosine nucleotides or does not comprise four or more consecutive guanosine nucleotides.
[0017] In some embodiments described herein, the inhibitory nucleic acid is 8 to 30 nucleotides in length.
[0018] In some embodiments described herein, at least one nucleotide of the inhibitory nucleic acid is a nucleotide analogue.
[0019] In some embodiments described herein, at least one nucleotide of the inhibitory nucleic acid comprises a 2' O-methyl, e.g., wherein each nucleotide of the inhibitory nucleic acid comprises a 2' O-methyl.
[0020] In some embodiments described herein, the inhibitory nucleic acid comprises at least one ribonucleotide, at least one deoxyribonucleotide, or at least one bridged nucleotide.
[0021] In some embodiments described herein, the bridged nucleotide is a LNA nucleotide, a cEt nucleotide or a ENA modified nucleotide.
[0022] In some embodiments described herein, each nucleotide of the inhibitory nucleic acid is a LNA nucleotide.
[0023] In some embodiments described herein, one or more of the nucleotides of the inhibitory nucleic acid comprise 2'-fluoro-deoxyribonucleotides and/or 2'-O-methyl nucleotides.
[0024] In some embodiments described herein, one or more of the nucleotides of the inhibitory nucleic acid comprise one of both of ENA nucleotide analogues or LNA nucleotides.
[0025] In some embodiments described herein, the nucleotides of the inhibitory nucleic acid comprise comprising phosphorothioate internucleotide linkages between at least two nucleotides, or between all nucleotides.
[0026] In some embodiments described herein, the inhibitory nucleic acid is a gapmer or a mixmer.
[0027] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Methods and materials are described herein for use in the present invention; other, suitable methods and materials known in the art can also be used. The materials, methods, and examples are illustrative only and not intended to be limiting. All publications, patent applications, patents, sequences, database entries, and other references mentioned herein are incorporated by reference in their entirety. In case of conflict, the present specification, including definitions, will control.
[0028] Other features and advantages of the invention will be apparent from the following detailed description and figures, and from the claims.
REFERENCE TO SEQUENCE LISTING
[0029] This application includes a sequence listing submitted herewith in electronic format. The entire content of this files is hereby incorporated by reference.
DESCRIPTION OF DRAWINGS
[0030] The patent or application file contains at least one drawing executed in color. Copies of this patent or patent application publication with color drawing(s) will be provided by the Office upon request and payment of the necessary fee.
[0031] FIGS. 1A-H. Telomeric RNAs produced by the sex chromosomes
[0032] A. TERRA RNA FISH followed by PAR DNA FISH using P34567 probes, which are subsets of BAC RP24-500I4 DNA. Higher exposure of TERRA RNA FISH revealed that multiple TERRA foci were sparely distributed across the nucleus in mES cells. DAPI detects nuclear DNA.
[0033] B. Map of the PAR and relative positions of BAC clones, RP24-143B12 and RP24-500I4. Locations of internal (TTAGGG) repeats shown in red. Dotted purple lines, incompletely assembled regions.
[0034] C. TERRA RNA FISH followed by PAR DNA FISH (n=204) using P34567 probes in ES cells. Lower exposure of TERRA RNA FISH showed that the dominant TERRA foci were colocalized with PAR DNA. 80-90% of TERRA signals localized to ChrX and Y.
[0035] D. Percent colocalization of PAR and TERRA signals. n=139 (male); 209 (female).
[0036] E. Two color RNA FISH detecting TERRA (Alexa488, green) and PAR transcripts (Cy3, red) in ES cells. Nick-translated BAC DNA was used to detect PAR RNA.
[0037] F. Top panel: Map of sub-BAC probes and PCR amplicons. Left panel: Northern blot analysis of PAR-TERRA RNA using either TERRA or 36K oligo probes in ES cells on differentiation days 0-12, as indicated. GAPDH, loading control. Right panel: Primer extension using an antisense TERRA oligo probe with PCR amplification using PAR-specific primer pairs located at 33, 36, and 39 k (kb) from the end of BAC RP24-500I4TERRA. +, with RT; -, without RT.
[0038] G. Northern blot analysis of PAR-TERRA in ES cells using TERRA-specific or PAR-specific oligo probes, as shown in panel F.
[0039] H. Higher exposure RNA FISH indicating colocalization of TERRA and PAR signals at both large and small foci in ES cells. Three-color RNA FISH (upper panel): TERRA oligo probe; PAR-specific probes, 47 k and 22 k. Two-color RNA FISH (lower panel): TERRA oligo probe; PAR specific probe, 31 k. DAPI was used for nuclear staining. Right graph, quantitation of colocalization.
[0040] FIGS. 2A-I. Mapping genomic PAR-TERRA binding sites by ChIRT-seq
[0041] A. To capture the PAR-TERRA transcripts, five DNA oligo probes were used: 22 k, 31 k, 34 k, 36 k, and 47 k. Each probe has multiple alignments to the RP24-500I4 BAC DNA around the telomeric repeats.
[0042] B. RNA slotblot analysis showing that TERRA-AS and PAR-31-AS probes specifically captured TERRA RNA by ChIRT. Total RNA was extracted from beads after ChIRT hybridization without RNase H elution.
[0043] C. Quantitative PCR showing the enrichment of PAR DNA in TERRA-AS ChIRT and PAR ChIRT, but not TERRA-S ChIRT in ES cells. TERRA-AS ChIRT used antisense DNA oligos against TERRA, TERRA-S ChIRT used TERRA sense probes as a control, and PAR ChIRT used PAR probes for the PAR transcripts.
[0044] D. Enrichment of PAR DNA following TERRA ChIRT was observed only when elution was performed with RNaseH. Enrichment was abolished in the RNase A pre-treated control (Pre-RNaseA).
[0045] E. Table of ChIRT results indicating the number of PAR and TERRA binding sites in ES cells on different days of differentiation and in MEFs. Different normalization methods produced similar results, as shown.
[0046] F. Scatterplot analysis comparing log2 coverages of TERRA and PAR ChIRT in indicated samples. Pearson's r shown. ChIRT results were normalized to input unless otherwise indicated.
[0047] G. TERRA ChIRT-seq showed enrichment for telomeric repeats DNA in female ES cells. Samples captured by TERRA-AS or TERRA-S. No-RNAseH for the TERRA-AS capture is also shown as a control.
[0048] H. Pie charts show relative representation of various genomic regions in TERRA (top) and PAR (bottom) ChIRT-seq experiments in female ES cells.
[0049] I. CEAS analysis shows significant over-representation of introns and noncoding regulatory regions. Exons are under-represented. ***, P<0.001 (one-sided binomial test). The genome reference was obtained from the ChIRT-seq input.
[0050] FIGS. 3A-D. X-linked PAR-TERRA RNA binds in cis and in trans to multiple chromosomes.
[0051] A. ChIRT-seq tracks showing PAR-TERRA enrichment at the ends of various chromosomes in female ES cells (top) and MEFs (bottom). TERRA ChIPT-seq data was normalized to input (TERRA/input), no-RNase H control (TERRA/no RNase H), or the sense control (TERRA/sense).
[0052] B. Magnified views of the female ES PAR-TERRA ChIRT-seq results for the pseudoautosomal regions of ChrX and ChrY.
[0053] C. Female ES ChIRT-seq tracks showing PAR-TERRA enrichment on multiple autosomes. Red bars, internal TTAGGG repeats. Grey bars, sequence gaps.
[0054] D. ChIRT-seq tracks of female ES cells showing PAR-TERRA binding to non-telomeric autosomal regions.
[0055] FIGS. 4A-G. Transcriptome analysis of PAR-TERRA-depleted cells.
[0056] A. Northern blot analysis of TERRA RNA shows depletion by treatment with gapmer LNA against TERRA or PAR in ES cells. Control, scramble LNA gapmer (Scr KD).
[0057] B. RNA FISH detecting TERRA (Alexa-488, green), or PAR (Cy5, cyan blue) after LNA knockdown in ES cells.
[0058] C. Venn diagram of genes affected by TERRA versus PAR KD. Number of genes in each circle and overlapped region is indicated. 56 genes are shared between TERRA and PAR KD in female ES cells; 36 in MEF.
[0059] D. Heatmap of differentially expressed genes in TERRA KD, PAR, and Scr KD. 56 shared genes were examined for ES cells; 36 shared genes for MEF. Scale in Log 10 FPKM.
[0060] E. Heatmap of differentially expressed genes in TERRA KD, PAR KD, and Scr KD ES cells or MEFs. 8 genes were shared in both ES cells and MEFs.
[0061] F. Probability density function for the 565 genes with and 14,724 genes without PAR-TERRA binding sites in the structural gene .+-.10Kb of flanking sequence, with respect to their likehood of changing gene expression following PAR-TERRA KD. Log2 fold-change (AFPKM) is plotted. After PAR-TERRA KD, there is a net downregulation for the group of genes with PAR-TERRA binding sites. Kolmogorov-Smirnoff (KS) test, P<0.0001.
[0062] G. Cumulative fraction that genes with or without PAR-TERRA sites would be up- or down-regulated following PAR or TERRA KD, as indicated. P-values determined by .chi..sup.2 analyses.
[0063] FIGS. 5A-F. PAR-TERRA protects escapees and genes of the subtelomeric/pseudoautosomal regions from silencing.
[0064] A. RNA-seq shows downregulation of subtelomeric genes following TERRA KD in ES cells. ChIRT-seq and post-KD RNA-seq tracks are shown.
[0065] B. RT-qPCR confirms that Tmx3 and Wls are downregulated upon TERRA KD in MEFs.
[0066] C. Whole-ChrX view of PAR-TERRA binding sites. Two regions (boxes) show high-level binding. Escapee genes shown below the chart.
[0067] D. Table showing the numbers of total and ChrX PAR-TERRA binding sites in female ES cells and in MEFs.
[0068] E. Probability density functions for escapees (n=15), Xi genes (n=438) subject to XCI. Escapee genes have higher PAR-TERRA binding densities relative to genes subject to XCI (P<0.001 for TERRA density, P<0.05 for PAR density, KS test).
[0069] F. RT-qPCR of pseudoautosomal genes following PAR or TERRA KD. P-values determined by the Student t-test.
[0070] FIGS. 6A-I. TERRAs regulate the gene expression on the PAR
[0071] A. Dynamics of Xist RNA spread following PAR-TERRA KD in female MEFs. Shown are tracks for Xist CHART-seq after Scr, TERRA, or PAR KD, and tracks for PAR-TERRA ChIRT-seq. Yellow-shaded region corresponds to the PAR-TERRA and Xist boundaries within Mid1.
[0072] B. Metagene analysis of PAR-TERRA density across XCI-repressed (n=438) and escapee genes (n=15). Relative PAR-TERRA density from PAR or TERRA ChIRT in MEFs was produced by CEAS analysis.
[0073] C. Scatterplot analysis comparing Xist coverage (log2 scale) in PAR-TERRA KD female MEFs relative to Scr KD on ChrX. The transcriptomic profiles are highly similar (Pearson's r>0.90). Outliers (dots) map to the "borders" of pseudoautosomal genes. Xist coverage files were normalized to the corresponding ChrX median values, and individual dots in the scatterplot represents an average of two biological replicates.
[0074] D. Metagene analysis of Xist density across XCI-repressed (n=438) and escapee genes (n=15) after TERRA KD or Scr KD in MEFs.
[0075] E. RNA FISH detecting TERRA (Alexa-488) and Xist (Cy3, red) in MEFs cells. 87% show colocalization (n=139).
[0076] F. 3D DNA FISH to determine the colocalization frequency of PAR (Cy3), the Xic (Ftx-Jpx probe; Cy5) and Hprt (FITC). A colocalization event is scored when two signals show overlapped pixels in 3D space. N=276 nuclei. P, determined by two-tailed Fisher's exact test.
[0077] G. 3D DNA FISH to determine the frequency of PAR-Xic colocalization after PAR-TERRA KD. A colocalization event is scored when two signals show overlapped pixels. N=256-272 nuclei. P, determined by two-tailed Fisher's exact test.
[0078] H. 2D model: PAR-TERRA protects escapees from Xist silencing by setting up a privileged compartment and walling off Xist at the 5' end of escapee genes. When PAR-TERRA is depleted, Xist spreads into the privileged compartment.
[0079] I. 3D Model: PAR-TERRA as an organizing center. PAR-TERRA forms a privileged nuclear compartment next to the Xist cloud. The Xi is partitioned spatially into a silent domain and an active domain for escapees.
[0080] FIGS. 7A-I. TERRAs regulate Xic pairing in mES cells
[0081] A. PAR-TERRA ChIRT-seq tracks of the Xic pairing center (red bar) in MEFs and in ES cells on d0, d3, and d7 of differentiation. Note prominent ES-specific PAR-TERRA peaks at the pairing center.
[0082] B. Cumulative frequency curves of inter-allelic differences measured between Xic-Xic, telomere-telomere, and Hprt-Hprt (bottom). Measurements were taken on DNA FISH experiments (representative DNA FISH image is shown) which detected Xic (Xist), TeloX (RP23-461E16, ChrX telomeric BAC), and Hprt (Cy5). ES cells on d0 and d4 shown. Normalized distance (ND)=distance/d, where d=2.times. (nuclear area/.pi.)0.5. ND 0.0-0.2 are shown. n=109-120. P values were determined using the KS test.
[0083] C. Cumulative frequency curves for inter-allelic telomeric distances for
[0084] ChrX (TeloX) or Chr2 (Telo2) on day 4 of ES differentiation. n=120-158. P values were determined using the KS test.
[0085] D. PAR-to-PAR pairing during female and male ES cell differentiation. n=246-385. P values were determined using the KS test.
[0086] E. Cumulative frequency of paired PAR DNA (TERRA RNA signals) in male ES cells on dO versus d4. DNA FISH shows that, on d4 of differentiation, the PAR's of ChrX and ChrY were frequently colocalized (one dot) or very close in 3D space (2 neighboring dots of <0.2 ND). N =149 (d0); 176 (d4). P value was determined using the KS test.
[0087] F. Cumulative frequency curves show that TERRA knockdown disrupted telomeric pairing in both female and male ES cells at 6 hr post-transfection at d4 of differentiation. P values were determined using the KS test. n=235-336.
[0088] G. Cumulative frequencty curve shows that TERRA knockdown disrupted Xic-Xic pairing in female ES cells at 3 hr post-trasfection on d4 of differentiation. P=0.001 (KS test). n=326-377.
[0089] H. Cumulative frequency curves indicate an increase in Xic-telo distances after 3 hours of TERRA KD in d4 female ES cells. P=0.009 (KS test). n=174-214.
[0090] Model: Without wishing to be bound by theory, it is believed that PAR-TERRA forms an organizing center to facilitate X-X pairing. (1) Prior to cell differentiation, the two female X-chromosomes are separated. (2) During early cell differentiation, trans-interactions between two telomeres bring the sex chromosomes in close promixity. (3) PAR-TERRA also drives the intra-chromosomal interactions between the Xic and the telomere in cis. (4) These events bring the Xic pairing center to the same juxta-telomeric compartment, accelerating the homology search between the two Xic pairing centers by the reduced effective search space. The pairing event induces initiation of XCI in female cells. In male cells, the telomeric pairing interaction also occurs, but is not followed by Xic pairing; thus, XCI is not initiated.
[0091] FIGS. 8A-E. Cytological analysis of PAR-TERRA transcripts. This figure relates to FIGS. 1A-H.
[0092] A. DNA FISH detecting PAR DNA using P34568 sub-probes of BAC RP24-500I4 DNA (Cy3, red), and X chromosomes (FITC labeled X painting probes, green) on metaphase spread in female ES cells. P345678 probes mark on the end of X chromosomes.
[0093] B. Electrophoresis of PCR products amplified from BAC RP24-500I4 DNA. The pools of P3, P4, P5, P6, and P8 PCR produces were used for generating P34568 sub-probes to detect PAR DNA in DNA FISH experiments.
[0094] C. RNA FISH detecting TERRA RNA in various human (lower panel) and mouse (upper panel) cell lines.
[0095] D. PAR-TERRA RNA is localized next to the Xist cloud. RNA FISH detecting TERRA (Alexa-488, green), I4-31 k (Cy5, cyan blue), and Xist (Cy3, red) in MEFs (upper panel). Image of the overexposed TERRA foci (green) to display moderate intensity of TERRA foci was shown in the lower panel. False color for 14-31 k (red, lower panel).
[0096] E. RNA FISH detecting TERRA (Cy5, cyan blue), Xist (FITC, green), the PAR transcripts with DNA oligo probes: I4-47 k (Alexa-488, green) and I4-22 k (Cy3, red) in MEFs (hybrid strain cas/mus, Xist clouds specifically on mus alleles), female ES cells (hybrid strand, cas/mus) and male ES cells (mus/mus). I4-22 k probes only mark on cas alleles.
[0097] FIGS. 9A-C. ChIRT-seq statistics. This figure relates to FIG. 2.
[0098] A. Quantitative PCR showing the enrichment of PAR DNA following ChIRT using oligo probes TERRA-AS (AS) that targets to TERRA transcripts or sense probes. Various detergents (0.1% NP40, or 0.1% SDS, or 0.1% N-lauryol Sarcosine) were added separately during the final DNA elution. NP40 retains RNase H activity better than other detergents in ChIRT elution.
[0099] B. Scatterplot comparing log2 coverages of biological replicates for PAR and TERRA ChIRT-seq analysis in ES cells. Pearson's r shown. Replicate 1 (Repl) was normalized with input. Replicate 2 (Rep2) was normalized to RNaseA pre-treated control.
[0100] C. Read statistics for two biological replicates of the PAR-TERRA ChIRT-seq analysis.
[0101] FIG. 10. PAR-TERRA RNA binds subtelomeric regions of select autosomes.
[0102] This figure relates to FIG. 3. ChIRT-seq tracks showing PAR-TERRA enrichment at the subtelomeric regions of Chr19, 8, and 16 in ES cells.
[0103] FIGS. 11A-C. PAR-TERRA knockdown by LNA gapmers. This figure relates to FIG. 4.
[0104] A. LNA gapmers efficiently knocked down PAR-TERRA in ES cells after 1 to 48 hours.
[0105] B. RNA FISH detecting TERRA (Alexa-488, green) after LNA transfection at various time points in ES cells.
[0106] C. As shown by scatterplots comparing log2 FPKM values, there is good correlation between biological replicates of RNA-seq biological replicates after PAR-TERRA KD in ES cells and MEFs. Pearson's r as shown.
[0107] FIGS. 12A-B. Analysis of gene expression following PAR-TERRA knockdown. This figure relates to FIG. 5.
[0108] A. ChIRP-seq tracks (red) for PAR-TERRA binding sites near differentially downregulated genes after PAR-TERRA KD in ES cells. RNA-seq coverage are FPM-normalized and tracks are shown in blue.
[0109] B. ChIRP-seq tracks (red) for PAR-TERRA binding sites near differentially upregulated genes after PAR-TERRA KD in ES cells. RNA-seq coverage are FPM-normalized and tracks are shown in blue.
[0110] FIGS. 13A-B. Telomeric pairing analysis: Whole distributions of inter-PAR distances. This figure relates to FIG. 7.
[0111] A. Distributions of PAR-PAR distances in female ES cells on days 0, 4, and 8 of differentiation. Normalized distance (ND)=PAR-PAR distance/d, where d=2.times.(nuclear area/.pi.)0.5.
[0112] B. Distributions of PAR-PAR distances in male ES cells on days 0, 4, and 8 of differentiation.
DETAILED DESCRIPTION
[0113] XCI is an epigenetic pathway that results in silencing of one X-chromosome in the female cell to compensate for unequal X-chromosome number between male (XY) and female (XX) cells (Starmer and Magnuson, 2009; Lee, 2011; Wutz, 2011; Disteche, 2012). The pathway is controlled by long noncoding RNAs (lncRNA) of the X-inactivation center (Xic). During early development and as recapitulated by differentiating embryonic stem (ES) cells, the X-to-autosome ratio is assessed and the XCI pathway is induced only when there is more than one X-chromosome in a diploid nucleus. This "counting" mechanism has been proposed to involve a titration of the X-linked Jpx lncRNA and autosomally encoded CTCF protein (Sun et al., 2013). In parallel, a transient interaction ("pairing") between two female X-chromosomes mediates the mutually exclusive choice of Xi and Xa (active X) (Bacher et al., 2006; Xu et al., 2006), with the subsequent action of Tsix lncRNA blocking XCI on the designated Xa (Lee et al., 1999) and the action of Xist lncRNA inducing whole-chromosome silencing on the designated Xi (Brown et al., 1992; Penny et al., 1996). Xist spreads along the Xi and recruits silencing complexes (Zhao et al., 2008; Wutz, 2011). With the exception of a small class of genes that escape XCI, nearly all 1000 genes on the Xi are subject to silencing. Although significant progress has been made, many aspects of XCI mechanism continue to elude understanding.
[0114] TERRA's affinity for sex chromosomes led the present inventors to hypothesize that TERRA might have non-telomeric functions; based on its association with sex chromosomes, possible roles surrounding the process of X-chromosome inactivation (XCI) were investigated. TERRA's association with the X-chromosome provides a new and potentially relevant avenue for exploration. Here we generate a map of TERRA's genomic binding sites, identify multiple non-telomeric targets, and interrogate the relationship of X-linked target sites to sex chromosome biology.
[0115] Here we have shown that TERRA function is not confined to telomeres, nor is it cis-limited in action. TERRA is predominantly expressed from the sex chromosomes and originates at least in part from the sub-telomeric region known as the pseudoautosomal region (PAR). Several lines of evidence argue that X- and P-linked "PAR-TERRA" is a continuous transcript and that PAR-TERRA comprises a major subclass of telomeric RNAs. First, similar results are obtained by Northern blot analysis using PAR and TERRA oligo probes (FIG. 1F,G). Second, primer extension indicates that TERRA and PAR RNA sequences are physically continuous (FIG. 1F). Third, RNA FISH experiments using TERRA and PAR probes demonstrate overlapping RNA signals (FIG. 1A,C,E,H). Fourth, ChIRT analysis indicates that nearly all TERRA-binding sites are also PAR-binding sites (FIG. 3,S3). Furthermore, knocking down PAR sequences using LNA gapmers results in TERRA depletion as well (FIG. 4A,B). FISH analysis demonstrates that PAR-TERRA establishes a compartment next to the telomeric ends of each sex chromosome, with a large PAR-TERRA RNA focus localizing next to but not overlapping the Xist RNA domain.
[0116] We postulate that PAR-TERRA is as an organizing center for two XCI-related processes (FIG. 6H-I, 7I). First, PAR-TERRA regulates gene regulation on a global scale (FIG. 4). Altogether, we identified hundreds of TERRA-binding sites throughout the genome in MEFs, of which 30-94 are X-linked. High PAR-TERRA coverage occurs near escapee genes, including genes of the pseudoautosomal region (FIG. 5). Perturbation experiments demonstrate that X-linked PAR-TERRA sites promote expression of escapee genes on the Xi. In the pseudoautosomal region, PAR-TERRA appears to protect genes from telomeric position effects. Analysis of Xist RNA localization indicated that Xist RNA is often enriched within defined peaks near escapees (Simon et al., 2013), such as the prominent peaks seen at Mid1 (FIG. 6A). These peaks suggest that Xist RNA may be sequestered at "boundaries" near escapee genes and be prevented from entering privileged loci. The idea of a boundary near escapees has been explored previously, with CTCF emerging as a candidate regulator (Filippova et al., 2005; Horvath et al., 2013). The loss of these Xist-enriched boundaries following PAR-TERRA depletion argues that PAR-TERRA also aids in formation of the Xist boundaries. We therefore propose a model in which PAR-TERRA holds Xist RNA in check and brings escapee genes into a privileged juxta-telomeric compartment that is permissive of transcription (FIG. 6H-I).
Methods of Reducing Expression of X-Linked Escapee Genes
[0117] The present methods include using antisense oligonucleotides (ASO) against PAR-TERRA RNA to downregulate expression of escapee genes. In humans, all chromosomes may have the capacity to produce TERRA transcripts, each from their own subtelomeric regions. These subtelomeric regions are chromosome-specific; therefore, the X and Y subtelomeric region (also called pseudoautosomal region) are distinct from autosomes. Sex-chromosome-specific effects can be achieved by targeting the PAR end of the telomeric transcript. Without wishing to be bound by theory, knocking down PAR, TERRA, or PAR-TERRA with an inhibitory nucleic acids, e.g., an ASO, may disrupt the organizing center and thereby induce escapee gene downregulation. These inhibitory nucleic acids can therefore be used to treat disorders of sex chromosome aneuploidy, e.g., Klinefelter Syndrome (XXY) and Triple X Syndrome (XXX), or any other condition that results in extra copies of all or part of the X-chromosome (e.g., unbalanced X-autosome translocations). While individuals with extra X chromosomes are mostly dosage compensated due to the counting mechanism (XXX women have two Xi's; XXY men have 1 Xi), they have uncompensated dosage of the 15% of X-linked genes that escape XCI.
[0118] Escapee genes include those listed in Table A.
TABLE-US-00001 TABLE E Escapee Genes Human Escapee Genes PR48; CALB3; SYAP1; HDHD1A; T54860; BC014382; AA348446; DKFZP564I1922; PRKX; Hs.431292; ITM2A; SRPX2; KIAA1817; MDS031; FLJ23018; HSU24186; Hs.271686; WBP5; TRPC5; TNFSF5; Hs.122516; Hs.404298; ARMCX4; FLJ11016; Hs.333016; DOCK11; LOC203427; CITED1; PLP1; PLCXD1; SLC25A6; LOC375793; ASMTL; DHRSX; FLJ43159; FLJ39679; CD99; XG; GYG2; ARSD; ARSE; Hs.399941; FLJ43700; AA971220; NLGN4X; FLJ12417; STS; Hs.186498; Hs.495638; PNPLA4; Hs.495641; Hs.348675; MGC17403; RAB9A; SEDL; Hs.41434; AA952971; FAM51A1; PIR; TMEM27; CA5BL; CA5B; AP1S2; Hs.121592; Hs.431654; CTPS2; Hs.431102; CXORF15; RBBP7; EIF1AX; EIF2S3; ZFX; Hs.458197; Hs.128084; USP9X; Hs.282780; Hs.86849; Hs.229338; DDX3X; MAOA; DUSP21; Hs.232417; AA130835; UBE1; INE1; JARID1C; A009X24; KIAA0522; Hs.87752; RPS4X; XIST; FLJ31610; F03810; PLXNB3; AVPR2; IKBKG; N74477; GPM6B; MGC39350; FUNDC1; SH3BGRL; L1CAM; GAB3; Hs.86443; TBL1X; GPR143; SMC1L1; RIBC1; Hs.258828; FLJ38564; NAP1L3; ZD89B07; SYTL4; Hs.527551~; ARHGAP4; RENBP; PCTK1; GRPR; CHM; HEIL2; HCFC1; OFD1; CRSP2; CLCN4; Hs.157695; MORF4L2; MYCL2; BRS3; ARD1; CXORF12; AF069137; Hs.108029; SH3KBP1; USP11; WAS; XEDAR; MAGEE1; ATP7A; Hs.445729; NXF3; LOC340544; PLS3; CUL4B; DXYS155E; MKRN4; 23809; MSL3L1; ASB11; NHS; PHEX; TIMP1; MLLT7; PIN4; COX7B; RAB40A; COL4A6; FLJ36576; UTP14A; COVA1; PLAC1; LOC159090; MAGEA8; ABCD1; C6.1A; CLIC2; PDZK10; REPS2; CDKL5; Hs.435570; Hs.446513; RS1; PHKA2; N53651; Hs.444490; ACATE2; TAB3; Hs.177986; BCoR; SYP; CCNB3; LOC51248; FLJ20105; Hs.37464; ABCB7; Hs.182171; BTK; RPL36A; GLA; BEX1; FLJ21174; NXT2; FLJ22679; Hs.425072; AMMECR1; Hs.61094; PAK3; LHFPL1; FLJ22965; UPF3B; MCTS1; GPC4; PHF6; MOSPD1; Hs.436787; CDR1; SLITRK2; LOC347512~; ZNF185; M78874; HCA127; FLJ34366; FLJ12525; FMR1; IRAK1; TKTL1; VBP1; Hs.522189~; KIAA1280; MID1; Hs.187608; ARHGAP6; H48827; M62076; GLRA2; EUROIMAGE 35971; CXorf23; SAT; AA601738; DMD; AA461044; FLJ42925; TM4SF2; FLJ43479; ATP6AP2; ZC35F11; SLC9A7; RGN; SLC38A5; GATA1; KCND1; GRIPAP1; FLJ21687; HADH2; UREB1; DT1P1A10; FGD1; Hs.13041; LOC90736; MAGEH1; W68846; DKFZp686L07201; LOC92249; Hs.38448; MSN; STARD8; EFNB1; PJA1; ACRC; GPR23; FLJ13042; TM4SF6; ARMCX1; ARMCX2; Hs.53997; MGC23947; RAB9B; FLJ33516; CLDN2; AI650369; H66935; PRPS1; PSMD10; APG4A; CHRDL1; KLHL13; NKAP; PEPP-2~; ODZ1; XPNPEP2; CXorf9; Hs.269127; FHL1; Hs.205436; FLJ38034; ATP11C; Hs.112784; Hs.127679; Hs.31542; LDOC1; CD99L2; PNMA5; SYBL1; G06389; TIMM8A; HPRT1; FAM9C; AW448933; UBQLN2; FLJ31204; PGPL; SHOX; ZBED1; KAL1; IL9R; IL9R Mouse Escapee Genes 1810030O07Rik; 5530601H04Rik; 5730416F02Rik; Abcb7; Aff2; Bgn; Car5b; Col4a6; Cox7b; Cxx1b; Ddx3x; Dkc1; Dmd; Dusp9; Eda; Eif2s3x; Fgf13; Firre; Frmpd4; Ftx; Gm5124; Gyk; Hmgb3; Il1rapl1; Irak1; Jpx; Kdm5c; Kdm6a; Kif4; Lage3; Mageb16; Mageb18; Mbtps2; Mid1; Msn; Naa10; Ndufb11; Ngfrap1; Nono; Pbdc1; Pdha1; Plp2; Pola1; Praf2; Prickle3; Rbbp7; Rbm10; Reps2; Rpl39; Rps4x; Sept6; Shroom4; Slc16a2; Slc25a5; Usp11; Wbp5; Xist; Flna; Ikbkg; Hcfc1; Huwe1; Maged1; Ogt; Asmt; and Erdr1 # 305 escapees in human, and 65 escapees in mouse # human escapees defined as Xi/Xa > 0.1 based on allele specific PCR in this paper: (Nature, 2005, Laura Carrell & Huntington F. Willard) X-inactivation profile reveals extensive variability in X-linked gene expression in females #mouse escapees defined as Xi/Xa > 0.1 or Xi read counts > 5 in MEF RNA-seq
[0119] Table B provides a list of escapee genes in the human pseudoautosomal region (PAR) of the X chromosome. Annotated gene name and full gene description are shown. Whether or not there is a Y-chromosome homologue is noted in the third column.
TABLE-US-00002 TABLE B Human PAR genes or Y orthologues or pseuodogene PR48 Protein phosphatase 2A 48 kDa subunit Pseudoautosomal; Y identity PLCXD1 Phosphatidylinositol phospholipase C, X domain 1 Pseudoautosomal; Y identity SLC25A6 Solute carrier family 25, member 6 Pseudoautosomal; Y identity LOC375793 Hypothetical protein with EST support Pseudoautosomal; Y identity ASMTL Acetylserotonin O-methyltransferase-like Pseudoautosomal; Y identity DHRSX Dehydrogenase/reductase (SDR) family Pseudoautosomal; Y identity FLJ43159 mRNA of unknown function Pseudoautosomal; Y identity FLJ39679 mRNA of unknown function Pseudoautosomal; Y identity CD99 CD99 antigen Pseudoautosomal; Y identity DXYS155E Lymphocyte surface protein Pseudoautosomal; Y identity PGPL Pseudoautosomal GTP-binding protein-like Pseudoautosomal; Y identity SHOX Short stature homeobox Pseudoautosomal; Y identity ZBED1 zinc finger, BED domain containing 1 Pseudoautosomal; Y identity SYBL1 Synaptobrevin-like 1 Pseudoautosomal; Y identity IL9R Interleukin 9 receptor Pseudoautosomal; Y identity RPS4X Ribosomal protein S4, X isoform Y orthologue UBE1 Ubiquitin-activating enzyme E1 Ancestral Y homolog JARID1C Jumonji, AT rich interactive domain 1C Y orthologue RAB9A Ras-related GTP-binding protein Y homology by BLAST SEDL Spondyloepiphyseal dysplasia, late Y pseudogene CXORF15 Chromosome X open reading frame 15 Y orthologues EIF1AX Eukaryotic translation initiation factor 4C Y orthologue ZFX Zinc finger protein X-linked Y orthologue USP9X Ubiquitin specific protease 9, X isoform Y orthologue DDX3X DEAD/H box 3, X-linked Y orthologue DUSP21 Dual specificity phosphatase 21 Y orthologue OFD1 Oral-facial-digital syndrome 1 gene Y pseudogene CRSP2 Cofactor required for Sp1 transcriptional activation Y pseudogene TAB3 TAK1-binding protein 3 Y pseudogene BCoR BCL6 co-repressor Y pseudogene FAM9C Family with sequence similarity 9, member C Y homology by BLAST HDHD1A Haloacid dehalogenase-like hydrolase domain 1 Y pseudogene NLGN4X Neuroligin 4 Y orthologue STS Steroid sulfatase Y pseudogene TBL1X Transducin (beta) like 1 Y orthologue GPR143 G protein-coupled receptor 143 Y pseudogene KAL1 Kallmann syndrome 1 sequence Y pseudogene AA348446 ESTs Y homology by BLAST DKFZP564I1922 Adlican Y pseudogene PRKX Protein kinase, X-linked Y orthologue XG Xg blood group Y pseudogene GYG2 Glycogenin 2 Y pseudogene ARSD Arylsulfatase D Y pseudogene ARSE Arylsulfatase E Y pseudogene Hs.399941 ESTs Y homology by BLAST FLJ43700 Hypothetical protein with mRNA & EST support Y homology by BLAST
[0120] The sequence of human PAR-TERRA is provided herewith as SEQ ID NO:1. The sequence of mouse PAR-TERRA is provided herewith as SED ID NO:2. In some embodiments, the sequence of an oligo targeting TERRA is 5'-TAA CCC TAA CCC TAA C-3' (SEQ ID NO:5); or PAR-TERRA is 5'-TCT CTG TCT CTG TCG C-3' (SEQ ID NO:6).
Method of Reducing Expression of From Non-Xi Genes
[0121] TERRA forms a special compartment for gene activation, not only for escapees on the Xi but also for autosomal genes and subtelomeric genes on autosomal ends, of which Chr 1, 3, 4, 8, 18, and 19 are shown herein (see, e.g., FIGS. 4, 5A-B). to PAR-TERRA and various Chromosome-specific TERRAs (produced from the subtelomeric regions) are also used to regulate genes outside of the Xi. The present methods can be applied to downregulate a network of Xa and subtelomeric autosomal genes involved in growth control and apoptosis, and other processes relevant to human disease. Two examples include active X (Xa) genes and the FSHD subtelomeric region of human Chromosome 4. The Xa also produces PAR-TERRA from its pseudoautosomal region and has multiple targets outside of its pseudoautosomal region. Targeting PAR, TERRA, or PAR-TERRA can reduce expression from the Xa. PAR-TERRA and TERRA also target thousands of autosomal sites with closely linked genes. A specific example include the Chr4 region associated with facioscapulohumeral muscular dystrophy (FSHD), which is located in the subtelomeric region of human Chr4 and contains coding genes FRG1,
[0122] FRG2, DUX4, and the long noncoding RNAs of forward and reverse orientations from the macrosatellite repeat, D4Z4. FSHD is caused by ectopic expression of these genes when the D4Z4 repeat contracts and becomes "activated". Thus, PAR, TERRA, or PAR-TERRA or Chr4-specific TERRA could be targeted to downregulated the associated subtelomeric genes.
[0123] In addition, PAR-TERRA knockdown resulted in downregulation of genes enriched for cell cycle and apoptosis genes (see Example 5). Thus, targeting PAR, TERRA, or PAR-TERRA transcripts can be an effective method of treating cancer and other human diseases where the X-chromosome and various growth control genes are frequently overexpressed. The sequence of human Chr4 FSHD region is provided herewith as SEQ ID NO:3.
Disorders of Sex Chromosome Aneuploidy
[0124] The present methods can be used to reduce expression of escapee genes in subjects with disorders of sex chromosome aneuploidy in which at least one extra X chromosome is present (referred to herein as a supernumerary X chromosome). The term Klinefelter syndrome (KS) describes a group of disorders in which at least one extra X chromosome is present in addition to a normal male karyotype, referred to in standard genetics nomenclature as 46,XY. Related to the KS group is 47,XXY aneuploidy, which is the most prevalent disorder of sex chromosomes in humans with a prevalence of about 1:500. Rarer sex chromosome aneuploidies include 48,XXYY and 48,XXXY (about 1:17,000 to 1:50,000); 49 ,XXXXY (about 1:85,000 to 1:100,000) births. See, e.g., Visootsak and Graham, Orphanet J Rare Dis. 2006; 1: 42; Targaltia et al., Acta Paediatr. 2011 June;100(6):851-60). Triple X syndrome (47 ,XXX) is a disorder in which at least one extra X chromosome is present in addition to a normal female karyotype; 48,XXXX and 49,XXXXX have also been described (Schoubben et al., Eur J Pediatr. 2011 October;170(10):1325-7). Conditions resulting from unbalanced X-autosome translocations or cancers (and other human diseases) with X-chromosomal aneuploidies may be treated similarly using the technology. These conditions can result in a large number of deleterious physical, psychological, and intellectual effects in affected individuals (see, e.g., Visootsak and Graham, Orphanet J Rare Dis. 2006; 1: 42; Schoubben et al., Eur J Pediatr. 2011 October;170(10):1325-7; Targaltia et al., Acta Paediatr. 2011 June;100(6):851-60).
Inhibitory Nucleic Acids Targeting PAR-TERRA or Other Chromosome-Specific TERRA
[0125] The methods and compositions described herein can include nucleic acids such as a small inhibitory RNA (siRNA) or LNA that targets (specifically binds, or is complementary to) PAR, PAR-TERRA, or other chromosome-specific TERRA (e.g., Chr4-specific, as produced from the subtelomeric region of human Chr4 which is associated with facioscapulohumeral muscular dystrophy (FSHD)) RNA. Inhibitory nucleic acids useful in the present methods and compositions include antisense oligonucleotides, ribozymes, external guide sequence (EGS) oligonucleotides, siRNA compounds, single- or double-stranded RNA interference (RNAi) compounds such as siRNA compounds, molecules comprising modified bases, locked nucleic acid molecules (LNA molecules), antagomirs, peptide nucleic acid molecules (PNA molecules), and other oligomeric compounds or oligonucleotide mimetics which hybridize to at least a portion of the target nucleic acid and modulate its function. In some embodiments, the inhibitory nucleic acids include antisense RNA, antisense DNA, chimeric antisense oligonucleotides, antisense oligonucleotides comprising modified linkages, interference RNA (RNAi), short interfering RNA (siRNA); a micro, interfering RNA (miRNA); a small, temporal RNA (stRNA); or a short, hairpin RNA (shRNA); small RNA-induced gene activation (RNAa); small activating RNAs (saRNAs), or combinations thereof. See, e.g., U.S. Ser. No. 62/010,342, WO 2012/065143, WO 2012/087983, and WO 2014/025887. However, in some embodiments the inhibitory nucleic acid is not an miRNA, an stRNA, an shRNA, an siRNA, an RNAi, or a dsRNA.
[0126] In some embodiments, the inhibitory nucleic acids are 10 to 50, 10 to 20, 10 to 25, 13 to 50, or 13 to 30 nucleotides in length. One having ordinary skill in the art will appreciate that this embodies inhibitory nucleic acids having complementary portions of 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 nucleotides in length, or any range therewithin. In some embodiments, the inhibitory nucleic acids are 15 nucleotides in length. In some embodiments, the inhibitory nucleic acids are 12 or 13 to 20, 25, or 30 nucleotides in length. One having ordinary skill in the art will appreciate that this embodies inhibitory nucleic acids having complementary portions of 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29 or 30 nucleotides in length, or any range therewithin (complementary portions refers to those portions of the inhibitory nucleic acids that are complementary to the target sequence).
[0127] The inhibitory nucleic acids useful in the present methods are sufficiently complementary to the target RNA, i.e., hybridize sufficiently well and with sufficient specificity, to give the desired effect. "Complementary" refers to the capacity for pairing, through hydrogen bonding, between two sequences comprising naturally or non-naturally occurring bases or analogs thereof. For example, if a base at one position of an inhibitory nucleic acid is capable of hydrogen bonding with a base at the corresponding position of a RNA, then the bases are considered to be complementary to each other at that position. 100% complementarity is not required.
[0128] Routine methods can be used to design an inhibitory nucleic acid that binds to the target sequence with sufficient specificity. In some embodiments, the methods include using bioinformatics methods known in the art to identify regions of secondary structure, e.g., one, two, or more stem-loop structures, or pseudoknots, and selecting those regions to target with an inhibitory nucleic acid. For example, "gene walk" methods can be used to optimize the inhibitory activity of the nucleic acid; for example, a series of oligonucleotides of 10-30 nucleotides spanning the length of a target RNA can be prepared, followed by testing for activity. Optionally, gaps, e.g., of 5-10 nucleotides or more, can be left between the target sequences to reduce the number of oligonucleotides synthesized and tested. GC content is preferably between about 30-60%. Contiguous runs of three or more Gs or Cs should be avoided where possible (for example, it may not be possible with very short (e.g., about 9-10 nt) oligonucleotides).
[0129] In some embodiments, the inhibitory nucleic acid molecules can be designed to target a specific region of the RNA sequence. For example, a specific functional region can be targeted, e.g., a region comprising a known RNA localization motif (i.e., a region complementary to the target nucleic acid on which the RNA acts). Alternatively or in addition, highly conserved regions can be targeted, e.g., regions identified by aligning sequences from disparate species such as primate (e.g., human) and rodent (e.g., mouse) and looking for regions with high degrees of identity. Percent identity can be determined routinely using basic local alignment search tools (BLAST programs) (Altschul et al., J. Mol. Biol., 1990, 215, 403-410; Zhang and Madden, Genome Res., 1997, 7, 649-656), e.g., using the default parameters.
[0130] Once one or more target regions, segments or sites have been identified, e.g., within a sequence known in the art or provided herein, inhibitory nucleic acid compounds are chosen that are sufficiently complementary to the target, i.e., that hybridize sufficiently well and with sufficient specificity (i.e., do not substantially bind to other non-target RNAs), to give the desired effect.
[0131] In the context of this invention, hybridization means hydrogen bonding, which may be Watson-Crick, Hoogsteen or reversed Hoogsteen hydrogen bonding, between complementary nucleoside or nucleotide bases. For example, adenine and thymine are complementary nucleobases which pair through the formation of hydrogen bonds. Complementary, as used herein, refers to the capacity for precise pairing between two nucleotides. For example, if a nucleotide at a certain position of an oligonucleotide is capable of hydrogen bonding with a nucleotide at the same position of a RNA molecule, then the inhibitory nucleic acid and the RNA are considered to be complementary to each other at that position. The inhibitory nucleic acids and the RNA are complementary to each other when a sufficient number of corresponding positions in each molecule are occupied by nucleotides which can hydrogen bond with each other. Thus, "specifically hybridisable" and "complementary" are terms which are used to indicate a sufficient degree of complementarity or precise pairing such that stable and specific binding occurs between the inhibitory nucleic acid and the RNA target. For example, if a base at one position of an inhibitory nucleic acid is capable of hydrogen bonding with a base at the corresponding position of a RNA, then the bases are considered to be complementary to each other at that position. 100% complementarity is not required.
[0132] It is understood in the art that a complementary nucleic acid sequence need not be 100% complementary to that of its target nucleic acid to be specifically hybridisable. A complementary nucleic acid sequence for purposes of the present methods is specifically hybridisable when binding of the sequence to the target RNA molecule interferes with the normal function of the target RNA to cause a loss of activity, and there is a sufficient degree of complementarity to avoid non-specific binding of the sequence to non-target RNA sequences under conditions in which specific binding is desired, e.g., under physiological conditions in the case of in vivo assays or therapeutic treatment, and in the case of in vitro assays, under conditions in which the assays are performed under suitable conditions of stringency. For example, stringent salt concentration will ordinarily be less than about 750 mM NaCl and 75 mM trisodium citrate, preferably less than about 500 mM NaCl and 50 mM trisodium citrate, and more preferably less than about 250 mM NaCl and 25 mM trisodium citrate. Low stringency hybridization can be obtained in the absence of organic solvent, e.g., formamide, while high stringency hybridization can be obtained in the presence of at least about 35% formamide, and more preferably at least about 50% formamide. Stringent temperature conditions will ordinarily include temperatures of at least about 30.degree. C., more preferably of at least about 37.degree. C., and most preferably of at least about 42.degree. C. Varying additional parameters, such as hybridization time, the concentration of detergent, e.g., sodium dodecyl sulfate (SDS), and the inclusion or exclusion of carrier DNA, are well known to those skilled in the art. Various levels of stringency are accomplished by combining these various conditions as needed. In a preferred embodiment, hybridization will occur at 30.degree. C. in 750 mM NaCl, 75 mM trisodium citrate, and 1% SDS. In a more preferred embodiment, hybridization will occur at 37.degree. C. in 500 mM NaCl, 50 mM trisodium citrate, 1% SDS, 35% formamide, and 100 .mu.g/ml denatured salmon sperm DNA (ssDNA). In a most preferred embodiment, hybridization will occur at 42.degree. C. in 250 mM NaCl, 25 mM trisodium citrate, 1% SDS, 50% formamide, and 200 .mu.g/ml ssDNA. Useful variations on these conditions will be readily apparent to those skilled in the art. For most applications, washing steps that follow hybridization will also vary in stringency. Wash stringency conditions can be defined by salt concentration and by temperature. As above, wash stringency can be increased by decreasing salt concentration or by increasing temperature. For example, stringent salt concentration for the wash steps will preferably be less than about 30 mM NaCl and 3 mM trisodium citrate, and most preferably less than about 15 mM NaCl and 1.5 mM trisodium citrate. Stringent temperature conditions for the wash steps will ordinarily include a temperature of at least about 25.degree. C., more preferably of at least about 42.degree. C., and even more preferably of at least about 68.degree. C. In a preferred embodiment, wash steps will occur at 25.degree. C. in 30 mM NaCl, 3 mM trisodium citrate, and 0.1% SDS. In a more preferred embodiment, wash steps will occur at 42.degree. C. in 15 mM NaCl, 1.5 mM trisodium citrate, and 0.1% SDS. In a more preferred embodiment, wash steps will occur at 68.degree. C. in 15 mM NaCl, 1.5 mM trisodium citrate, and 0.1% SDS. Additional variations on these conditions will be readily apparent to those skilled in the art. Hybridization techniques are well known to those skilled in the art and are described, for example, in Benton and Davis (Science 196:180, 1977); Grunstein and Hogness (Proc. Natl. Acad. Sci., USA 72:3961, 1975); Ausubel et al. (Current Protocols in Molecular Biology, Wiley Interscience, New York, 2001); Berger and Kimmel (Guide to Molecular Cloning Techniques, 1987, Academic Press, New York); and Sambrook et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, New York.
[0133] In general, the inhibitory nucleic acids useful in the methods described herein have at least 80% sequence complementarity to a target region within the target nucleic acid, e.g., 90%, 95%, or 100% sequence complementarity to the target region within an RNA. For example, an antisense compound in which 18 of 20 nucleobases of the antisense oligonucleotide are complementary, and would therefore specifically hybridize, to a target region would represent 90 percent complementarity. Percent complementarity of an inhibitory nucleic acid with a region of a target nucleic acid can be determined routinely using basic local alignment search tools (BLAST programs) (Altschul et al., J. Mol. Biol., 1990, 215, 403-410; Zhang and Madden, Genome Res., 1997, 7, 649-656). Inhibitory nucleic acids that hybridize to an RNA can be identified through routine experimentation. In general the inhibitory nucleic acids must retain specificity for their target, i.e., must not directly bind to, or directly significantly affect expression levels of, transcripts other than the intended target.
[0134] For further disclosure regarding inhibitory nucleic acids, please see US2010/0317718 (antisense oligos); US2010/0249052 (double-stranded ribonucleic acid (dsRNA)); US2009/0181914 and US2010/0234451 (LNAs); US2007/0191294 (siRNA analogues); US2008/0249039 (modified siRNA); and WO2010/129746 and WO2010/040112 (inhibitory nucleic acids), as well as WO 2012/065143, WO 2012/087983, and WO 2014/025887 (inhibitory nucleic acids targeting non-coding RNAs/supRNAss), all of which are incorporated herein by reference in their entirety.
Antisense
[0135] In some embodiments, the inhibitory nucleic acids are antisense oligonucleotides. Antisense oligonucleotides are typically designed to block expression of a DNA or RNA target by binding to the target and (without wishing to be bound by theory) halting expression at the level of transcription, translation, or splicing. Antisense oligonucleotides of the present invention are complementary nucleic acid sequences designed to hybridize under stringent conditions to an RNA. Thus, oligonucleotides are chosen that are sufficiently complementary to the target, i.e., that hybridize sufficiently well and with sufficient specificity, to give the desired effect.
siRNA/shRNA
[0136] In some embodiments, the nucleic acid sequence that is complementary to an target RNA can be an interfering RNA, including but not limited to a small interfering RNA ("siRNA") or a small hairpin RNA ("shRNA"). Methods for constructing interfering RNAs are well known in the art. For example, the interfering RNA can be assembled from two separate oligonucleotides, where one strand is the sense strand and the other is the antisense strand, wherein the antisense and sense strands are self-complementary (i.e., each strand comprises nucleotide sequence that is complementary to nucleotide sequence in the other strand; such as where the antisense strand and sense strand form a duplex or double stranded structure); the antisense strand comprises nucleotide sequence that is complementary to a nucleotide sequence in a target nucleic acid molecule or a portion thereof (i.e., an undesired gene) and the sense strand comprises nucleotide sequence corresponding to the target nucleic acid sequence or a portion thereof. Alternatively, interfering RNA is assembled from a single oligonucleotide, where the self-complementary sense and antisense regions are linked by means of nucleic acid based or non-nucleic acid-based linker(s). The interfering RNA can be a polynucleotide with a duplex, asymmetric duplex, hairpin or asymmetric hairpin secondary structure, having self-complementary sense and antisense regions, wherein the antisense region comprises a nucleotide sequence that is complementary to nucleotide sequence in a separate target nucleic acid molecule or a portion thereof and the sense region having nucleotide sequence corresponding to the target nucleic acid sequence or a portion thereof The interfering can be a circular single-stranded polynucleotide having two or more loop structures and a stem comprising self-complementary sense and antisense regions, wherein the antisense region comprises nucleotide sequence that is complementary to nucleotide sequence in a target nucleic acid molecule or a portion thereof and the sense region having nucleotide sequence corresponding to the target nucleic acid sequence or a portion thereof, and wherein the circular polynucleotide can be processed either in vivo or in vitro to generate an active siRNA molecule capable of mediating RNA interference.
[0137] In some embodiments, the interfering RNA coding region encodes a self-complementary RNA molecule having a sense region, an antisense region and a loop region. Such an RNA molecule when expressed desirably forms a "hairpin" structure, and is referred to herein as an "shRNA." The loop region is generally between about 2 and about 10 nucleotides in length. In some embodiments, the loop region is from about 6 to about 9 nucleotides in length. In some embodiments, the sense region and the antisense region are between about 15 and about 20 nucleotides in length. Following post-transcriptional processing, the small hairpin RNA is converted into a siRNA by a cleavage event mediated by the enzyme Dicer, which is a member of the RNase III family. The siRNA is then capable of inhibiting the expression of a gene with which it shares homology. For details, see Brummelkamp et al., Science 296:550-553, (2002); Lee et al, Nature Biotechnol., 20, 500-505, (2002); Miyagishi and Taira, Nature Biotechnol 20:497-500, (2002); Paddison et al. Genes & Dev. 16:948-958, (2002); Paul, Nature Biotechnol, 20, 505-508, (2002); Sui, Proc. Natl. Acad. Sd. USA, 99(6), 5515-5520, (2002); Yu et al. Proc NatlAcadSci USA 99:6047-6052, (2002).
[0138] The target RNA cleavage reaction guided by siRNAs is highly sequence specific. In general, siRNA containing a nucleotide sequences identical to a portion of the target nucleic acid are preferred for inhibition. However, 100% sequence identity between the siRNA and the target gene is not required to practice the present invention. Thus the invention has the advantage of being able to tolerate sequence variations that might be expected due to genetic mutation, strain polymorphism, or evolutionary divergence. For example, siRNA sequences with insertions, deletions, and single point mutations relative to the target sequence have also been found to be effective for inhibition. Alternatively, siRNA sequences with nucleotide analog substitutions or insertions can be effective for inhibition. In general the siRNAs must retain specificity for their target, i.e., must not directly bind to, or directly significantly affect expression levels of, transcripts other than the intended target.
Ribozymes
[0139] Trans-cleaving enzymatic nucleic acid molecules can also be used; they have shown promise as therapeutic agents for human disease (Usman & McSwiggen, 1995 Ann. Rep. Med. Chem. 30, 285-294; Christoffersen and Marr, 1995 J. Med. Chem. 38, 2023-2037). Enzymatic nucleic acid molecules can be designed to cleave specific RNA targets within the background of cellular RNA. Such a cleavage event renders the RNA non- functional.
[0140] In general, enzymatic nucleic acids with RNA cleaving activity act by first binding to a target RNA. Such binding occurs through the target binding portion of a enzymatic nucleic acid which is held in close proximity to an enzymatic portion of the molecule that acts to cleave the target RNA. Thus, the enzymatic nucleic acid first recognizes and then binds a target RNA through complementary base pairing, and once bound to the correct site, acts enzymatically to cut the target RNA. Strategic cleavage of such a target RNA will destroy its ability to direct synthesis of an encoded protein. After an enzymatic nucleic acid has bound and cleaved its RNA target, it is released from that RNA to search for another target and can repeatedly bind and cleave new targets.
[0141] Several approaches such as in vitro selection (evolution) strategies (Orgel, 1979, Proc. R. Soc. London, B 205, 435) have been used to evolve new nucleic acid catalysts capable of catalyzing a variety of reactions, such as cleavage and ligation of phosphodiester linkages and amide linkages, (Joyce, 1989, Gene, 82, 83-87; Beaudry et al., 1992, Science 257, 635-641; Joyce, 1992, Scientific American 267, 90-97; Breaker et al, 1994, TIBTECH 12, 268; Bartel et al, 1993, Science 261 :1411-1418; Szostak, 1993, TIBS 17, 89-93; Kumar et al, 1995, FASEB J., 9, 1183; Breaker, 1996, Curr. Op. Biotech., 1, 442). The development of ribozymes that are optimal for catalytic activity would contribute significantly to any strategy that employs RNA-cleaving ribozymes for the purpose of regulating gene expression. The hammerhead ribozyme, for example, functions with a catalytic rate (kcat) of about 1 min.sup.-1 in the presence of saturating (10 rnM) concentrations of Mg.sup.2+ cofactor. An artificial "RNA ligase" ribozyme has been shown to catalyze the corresponding self-modification reaction with a rate of about 100 min.sup.-1. In addition, it is known that certain modified hammerhead ribozymes that have substrate binding arms made of DNA catalyze RNA cleavage with multiple turn-over rates that approach 100 min.sup.-1.
Modified Inhibitory Nucleic Acids
[0142] In some embodiments, the inhibitory nucleic acids used in the methods described herein are modified, e.g., comprise one or more modified bonds or bases. A number of modified bases include phosphorothioate, methylphosphonate, peptide nucleic acids, or locked nucleic acid (LNA) molecules. Some inhibitory nucleic acids are fully modified, while others are chimeric and contain two or more chemically distinct regions, each made up of at least one nucleotide. These inhibitory nucleic acids typically contain at least one region of modified nucleotides that confers one or more beneficial properties (such as, for example, increased nuclease resistance, increased uptake into cells, increased binding affinity for the target) and a region that is a substrate for enzymes capable of cleaving RNA:DNA or RNA:RNA hybrids. Chimeric inhibitory nucleic acids of the invention may be formed as composite structures of two or more oligonucleotides, modified oligonucleotides, oligonucleosides and/or oligonucleotide mimetics as described above. Such compounds have also been referred to in the art as hybrids or gapmers. Representative United States patents that teach the preparation of such hybrid structures comprise, but are not limited to, U.S. Pat. Nos. 5,013,830; 5,149,797; 5,220,007; 5,256,775; 5,366,878; 5,403,711; 5,491,133; 5,565,350; 5,623,065; 5,652,355; 5,652,356; and 5,700,922, each of which is herein incorporated by reference.
[0143] In some embodiments, the inhibitory nucleic acid comprises at least one nucleotide modified at the 2' position of the sugar, most preferably a 2'-O-alkyl, 2'-O-alkyl-O-alkyl or 2'-fluoro-modified nucleotide. In other preferred embodiments, RNA modifications include 2'-fluoro, 2'-amino and 2' O-methyl modifications on the ribose of pyrimidines, abasic residues or an inverted base at the 3' end of the RNA. Such modifications are routinely incorporated into oligonucleotides and these oligonucleotides have been shown to have a higher Tm (i.e., higher target binding affinity) than; 2'-deoxyoligonucleotides against a given target.
[0144] A number of nucleotide and nucleoside modifications have been shown to make the inhibitory nucleic acid into which they are incorporated more resistant to nuclease digestion than the native oligodeoxynucleotide; these modified oligos survive intact for a longer time than unmodified inhibitory nucleic acids. Specific examples of modified inhibitory nucleic acids include those comprising modified backbones, for example, phosphorothioates, phosphotriesters, methyl phosphonates, short chain alkyl or cycloalkyl intersugar linkages or short chain heteroatomic or heterocyclic intersugar linkages. Most preferred are inhibitory nucleic acids with phosphorothioate backbones and those with heteroatom backbones, particularly CH2--NH--O--CH2, .about.CH,.about.N(CH3).about.O.about.CH2 (known as a methylene(methylimino) or MMI backbone], CH2--O--N (CH3)--CH2, CH2--N (CH3)--N (CH3)--CH2 and O--N (CH3)--CH2 --CH2 backbones, wherein the native phosphodiester backbone is represented as O--P--O--CH,); amide backbones (see De Mesmaeker et al. Ace. Chem. Res. 1995, 28:366-374); morpholino backbone structures (see Summerton and Weller, U.S. Pat. No. 5,034,506); peptide nucleic acid (PNA) backbone (wherein the phosphodiester backbone of the inhibitory nucleic acid is replaced with a polyamide backbone, the nucleotides being bound directly or indirectly to the aza nitrogen atoms of the polyamide backbone, see Nielsen et al., Science 1991, 254, 1497). Phosphorus-containing linkages include, but are not limited to, phosphorothioates, chiral phosphorothioates, phosphorodithioates, phosphotriesters, aminoalkylphosphotriesters, methyl and other alkyl phosphonates comprising 3'alkylene phosphonates and chiral phosphonates, phosphinates, phosphoramidates comprising 3'-amino phosphoramidate and aminoalkylphosphoramidates, thionophosphoramidates, thionoalkylphosphonates, thionoalkylphosphotriesters, and boranophosphates having normal 3'-5' linkages, 2'-5' linked analogs of these, and those having inverted polarity wherein the adjacent pairs of nucleoside units are linked 3'-5' to 5'-3' or 2'-5' to 5'-2'; see U.S. Pat. Nos. 3,687,808; 4,469,863; 4,476,301; 5,023,243; 5,177,196; 5,188,897; 5,264,423; 5,276,019; 5,278,302; 5,286,717; 5,321,131; 5,399,676; 5,405,939; 5,453,496; 5,455, 233; 5,466,677; 5,476,925; 5,519,126; 5,536,821; 5,541,306; 5,550,111; 5,563, 253; 5,571,799; 5,587,361; and 5,625,050.
[0145] Morpholino-based oligomeric compounds are described in Dwaine A. Braasch and David R. Corey, Biochemistry, 2002, 41(14), 4503-4510); Genesis, volume 30, issue 3, 2001; Heasman, J., Dev. Biol., 2002, 243, 209-214; Nasevicius et al., Nat. Genet., 2000, 26, 216-220; Lacerra et al., Proc. Natl. Acad. Sci., 2000, 97, 9591-9596; and U.S. Pat. No. 5,034,506, issued Jul. 23, 1991.
[0146] Cyclohexenyl nucleic acid inhibitory nucleic acid mimetics are described in Wang et al., J. Am. Chem. Soc., 2000, 122, 8595-8602.
[0147] Modified inhibitory nucleic acid backbones that do not include a phosphorus atom therein have backbones that are formed by short chain alkyl or cycloalkyl internucleoside linkages, mixed heteroatom and alkyl or cycloalkyl internucleoside linkages, or one or more short chain heteroatomic or heterocyclic internucleoside linkages. These comprise those having morpholino linkages (formed in part from the sugar portion of a nucleoside); siloxane backbones; sulfide, sulfoxide and sulfone backbones; formacetyl and thioformacetyl backbones; methylene formacetyl and thioformacetyl backbones; alkene containing backbones; sulfamate backbones;
[0148] methyleneimino and methylenehydrazino backbones; sulfonate and sulfonamide backbones; amide backbones; and others having mixed N, O, S and CH2 component parts; see U.S. Pat. Nos. 5,034,506; 5,166,315; 5,185,444; 5,214,134; 5,216,141; 5,235,033; 5,264, 562; 5, 264,564; 5,405,938; 5,434,257; 5,466,677; 5,470,967; 5,489,677; 5,541,307; 5,561,225; 5,596, 086; 5,602,240; 5,610,289; 5,602,240; 5,608,046; 5,610,289; 5,618,704; 5,623, 070; 5,663,312; 5,633,360; 5,677,437; and 5,677,439, each of which is herein incorporated by reference.
[0149] One or more substituted sugar moieties can also be included, e.g., one of the following at the 2' position: OH, SH, SCH.sub.3, F, OCN, OCH.sub.3OCH.sub.3, OCH.sub.3O(CH.sub.2)n CH.sub.3, O(CH.sub.2)n NH.sub.2 or O(CH.sub.2)n CH.sub.3 where n is from 1 to about 10; Ci to C10 lower alkyl, alkoxyalkoxy, substituted lower alkyl, alkaryl or aralkyl; Cl; Br; CN; CF3 ; OCF3; O-, S-, or N-alkyl; O-, S-, or N-alkenyl; SOCH3; SO2 CH3; ONO2; NO2; N3; NH2; heterocycloalkyl; heterocycloalkaryl; aminoalkylamino; polyalkylamino; substituted silyl; an RNA cleaving group; a reporter group; an intercalator; a group for improving the pharmacokinetic properties of an inhibitory nucleic acid; or a group for improving the pharmacodynamic properties of an inhibitory nucleic acid and other substituents having similar properties. A preferred modification includes 2'-methoxyethoxy [2'-0-CH.sub.2CH.sub.2OCH.sub.3, also known as 2'-O-(2-methoxyethyl)] (Martin et al, Hely. Chim. Acta, 1995, 78, 486). Other preferred modifications include 2'-methoxy (2'-O--CH.sub.3), 2'-propoxy (2'--OCH.sub.2CH.sub.2CH.sub.3) and 2'-fluoro (2'-F). Similar modifications may also be made at other positions on the inhibitory nucleic acid, particularly the 3' position of the sugar on the 3' terminal nucleotide and the 5' position of 5' terminal nucleotide. Inhibitory nucleic acids may also have sugar mimetics such as cyclobutyls in place of the pentofuranosyl group.
[0150] Inhibitory nucleic acids can also include, additionally or alternatively, nucleobase (often referred to in the art simply as "base") modifications or substitutions. As used herein, "unmodified" or "natural" nucleobases include adenine (A), guanine (G), thymine (T), cytosine (C) and uracil (U). Modified nucleobases include nucleobases found only infrequently or transiently in natural nucleic acids, e.g., hypoxanthine, 6-methyladenine, 5-Me pyrimidines, particularly 5-methylcytosine (also referred to as 5-methyl-2' deoxycytosine and often referred to in the art as 5-Me--C), 5-hydroxymethylcytosine (HMC), glycosyl HMC and gentobiosyl HMC, as well as synthetic nucleobases, e.g., 2-aminoadenine, 2-(methylamino)adenine, 2-(imidazolylalkyl)adenine, 2-(aminoalklyamino)adenine or other heterosubstituted alkyladenines, 2-thiouracil, 2-thiothymine, 5-bromouracil, 5-hydroxymethyluracil, 8-azaguanine, 7-deazaguanine, N6 (6-aminohexyl)adenine and 2,6-diaminopurine. Kornberg, A., DNA Replication, W. H. Freeman & Co., San Francisco, 1980, pp75-77; Gebeyehu, G., et al. Nucl. Acids Res. 1987, 15:4513). A "universal" base known in the art, e.g., inosine, can also be included. 5-Me--C substitutions have been shown to increase nucleic acid duplex stability by 0.6-1.2<0>C. (Sanghvi, Y. S., in Crooke, S. T. and Lebleu, B., eds., Antisense Research and Applications, CRC Press, Boca Raton, 1993, pp. 276-278) and are presently preferred base substitutions.
[0151] It is not necessary for all positions in a given inhibitory nucleic acid to be uniformly modified, and in fact more than one of the aforementioned modifications may be incorporated in a single inhibitory nucleic acid or even at within a single nucleoside within an inhibitory nucleic acid.
[0152] In some embodiments, both a sugar and an internucleoside linkage, i.e., the backbone, of the nucleotide units are replaced with novel groups. The base units are maintained for hybridization with an appropriate nucleic acid target compound. One such oligomeric compound, an inhibitory nucleic acid mimetic that has been shown to have excellent hybridization properties, is referred to as a peptide nucleic acid (PNA). In PNA compounds, the sugar-backbone of an inhibitory nucleic acid is replaced with an amide containing backbone, for example, an aminoethylglycine backbone. The nucleobases are retained and are bound directly or indirectly to aza nitrogen atoms of the amide portion of the backbone. Representative United States patents that teach the preparation of PNA compounds comprise, but are not limited to, U.S. Pat. Nos. 5,539,082; 5,714,331; and 5,719,262, each of which is herein incorporated by reference . Further teaching of PNA compounds can be found in Nielsen et al, Science, 1991, 254, 1497-1500.
[0153] Inhibitory nucleic acids can also include one or more nucleobase (often referred to in the art simply as "base") modifications or substitutions. As used herein, "unmodified" or "natural" nucleobases comprise the purine bases adenine (A) and guanine (G), and the pyrimidine bases thymine (T), cytosine (C) and uracil (U). Modified nucleobases comprise other synthetic and natural nucleobases such as 5-methylcytosine (5-me-C), 5-hydroxymethyl cytosine, xanthine, hypoxanthine, 2-aminoadenine, 6-methyl and other alkyl derivatives of adenine and guanine, 2-propyl and other alkyl derivatives of adenine and guanine, 2-thiouracil, 2-thiothymine and 2-thiocytosine, 5-halouracil and cytosine, 5-propynyl uracil and cytosine, 6-azo uracil, cytosine and thymine, 5-uracil (pseudo-uracil), 4-thiouracil, 8-halo, 8-amino, 8-thiol, 8- thioalkyl, 8-hydroxyl and other 8-substituted adenines and guanines, 5-halo particularly 5- bromo, 5-trifluoromethyl and other 5-substituted uracils and cytosines, 7-methylquanine and 7-methyladenine, 8-azaguanine and 8-azaadenine, 7-deazaguanine and 7-deazaadenine and 3- deazaguanine and 3-deazaadenine.
[0154] Further, nucleobases comprise those disclosed in U.S. Pat. No. 3,687,808, those disclosed in `The Concise Encyclopedia of Polymer Science And Engineering`, pages 858-859, Kroschwitz, J. I., ed. John Wiley & Sons, 1990, those disclosed by Englisch et al., Angewandle Chemie, International Edition', 1991, 30, page 613, and those disclosed by Sanghvi, Y. S., Chapter 15, Antisense Research and Applications', pages 289-302, Crooke, S. T. and Lebleu, B. ea., CRC Press, 1993. Certain of these nucleobases are particularly useful for increasing the binding affinity of the oligomeric compounds of the invention. These include 5-substituted pyrimidines, 6-azapyrimidines and N-2, N-6 and 0-6 substituted purines, comprising 2-aminopropyladenine, 5-propynyluracil and 5-propynylcytosine. 5-methylcytosine substitutions have been shown to increase nucleic acid duplex stability by 0.6-1.2<0>C (Sanghvi, Y. S., Crooke, S. T. and Lebleu, B., eds, `Antisense Research and Applications`, CRC Press, Boca Raton, 1993, pp. 276-278) and are presently preferred base substitutions, even more particularly when combined with 2'-O-methoxyethyl sugar modifications. Modified nucleobases are described in U.S. Pat. Nos. 3,687,808, as well as U.S. Pat. Nos. 4,845,205; 5,130,302; 5,134,066; 5,175,273; 5,367,066; 5,432,272; 5,457,187; 5,459,255; 5,484,908; 5,502,177; 5,525,711; 5,552,540; 5,587,469; 5,596,091; 5,614,617; 5,750,692, and 5,681,941, each of which is herein incorporated by reference.
[0155] In some embodiments, the inhibitory nucleic acids are chemically linked to one or more moieties or conjugates that enhance the activity, cellular distribution, or cellular uptake of the inhibitory nucleic acid. Such moieties comprise but are not limited to, lipid moieties such as a cholesterol moiety (Letsinger et al., Proc. Natl. Acad. Sci. USA, 1989, 86, 6553-6556), cholic acid (Manoharan et al., Bioorg. Med. Chem. Let., 1994, 4, 1053-1060), a thioether, e.g., hexyl-S-tritylthiol (Manoharan et al, Ann. N. Y. Acad. Sci., 1992, 660, 306-309; Manoharan et al., Bioorg. Med. Chem. Let., 1993, 3, 2765-2770), a thiocholesterol (Oberhauser et al., Nucl. Acids Res., 1992, 20, 533-538), an aliphatic chain, e.g., dodecandiol or undecyl residues (Kabanov et al., FEBS Lett., 1990, 259, 327-330; Svinarchuk et al., Biochimie, 1993, 75, 49-54), a phospholipid, e.g., di-hexadecyl-rac-glycerol or triethylammonium 1 ,2-di-O-hexadecyl-rac-glycero-3-H-phosphonate (Manoharan et al., Tetrahedron Lett., 1995, 36, 3651-3654; Shea et al., Nucl. Acids Res., 1990, 18, 3777-3783), a polyamine or a polyethylene glycol chain (Mancharan et al., Nucleosides & Nucleotides, 1995, 14, 969-973), or adamantane acetic acid (Manoharan et al., Tetrahedron Lett., 1995, 36, 3651-3654), a palmityl moiety (Mishra et al., Biochim. Biophys. Acta, 1995, 1264, 229-237), or an octadecylamine or hexylamino-carbonyl-t oxycholesterol moiety (Crooke et al., J. Pharmacol. Exp. Ther., 1996, 277, 923-937). See also U.S. Pat. Nos. 4,828,979; 4,948,882; 5,218,105; 5,525,465; 5,541,313; 5,545,730; 5,552, 538; 5,578,717, 5,580,731; 5,580,731; 5,591,584; 5,109,124; 5,118,802; 5,138,045; 5,414,077; 5,486, 603; 5,512,439; 5,578,718; 5,608,046; 4,587,044; 4,605,735; 4,667,025; 4,762, 779; 4,789,737; 4,824,941; 4,835,263; 4,876,335; 4,904,582; 4,958,013; 5,082, 830; 5,112,963; 5,214,136; 5,082,830; 5,112,963; 5,214,136; 5, 245,022; 5,254,469; 5,258,506; 5,262,536; 5,272,250; 5,292,873; 5,317,098; 5,371,241, 5,391, 723; 5,416,203, 5,451,463; 5,510,475; 5,512,667; 5,514,785; 5, 565,552; 5,567,810; 5,574,142; 5,585,481; 5,587,371; 5,595,726; 5,597,696; 5,599,923; 5,599,928 and 5,688,941, each of which is herein incorporated by reference.
[0156] These moieties or conjugates can include conjugate groups covalently bound to functional groups such as primary or secondary hydroxyl groups. Conjugate groups of the invention include intercalators, reporter molecules, polyamines, polyamides, polyethylene glycols, polyethers, groups that enhance the pharmacodynamic properties of oligomers, and groups that enhance the pharmacokinetic properties of oligomers. Typical conjugate groups include cholesterols, lipids, phospholipids, biotin, phenazine, folate, phenanthridine, anthraquinone, acridine, fluoresceins, rhodamines, coumarins, and dyes. Groups that enhance the pharmacodynamic properties, in the context of this invention, include groups that improve uptake, enhance resistance to degradation, and/or strengthen sequence-specific hybridization with the target nucleic acid. Groups that enhance the pharmacokinetic properties, in the context of this invention, include groups that improve uptake, distribution, metabolism or excretion of the compounds of the present invention. Representative conjugate groups are disclosed in International Patent Application No. PCT/US92/09196, filed Oct. 23, 1992, and U.S. Pat. No. 6,287,860, which are incorporated herein by reference. Conjugate moieties include, but are not limited to, lipid moieties such as a cholesterol moiety, cholic acid, a thioether, e.g., hexyl-5-tritylthiol, a thiocholesterol, an aliphatic chain, e.g., dodecandiol or undecyl residues, a phospholipid, e.g., di-hexadecyl-rac-glycerol or triethylammonium 1,2-di-O-hexadecyl-rac-glycero-3-H-phosphonate, a polyamine or a polyethylene glycol chain, or adamantane acetic acid, a palmityl moiety, or an octadecylamine or hexylamino-carbonyl-oxy cholesterol moiety. See, e.g., U.S. Pat. Nos. 4,828,979; 4,948,882; 5,218,105; 5,525,465; 5,541,313; 5,545,730; 5,552,538; 5,578,717, 5,580,731; 5,580,731; 5,591,584; 5,109,124; 5,118,802; 5,138,045; 5,414,077; 5,486,603; 5,512,439; 5,578,718; 5,608,046; 4,587,044; 4,605,735; 4,667,025; 4,762,779; 4,789,737; 4,824,941; 4,835,263; 4,876,335; 4,904,582; 4,958,013; 5,082,830; 5,112,963; 5,214,136; 5,082,830; 5,112,963; 5,214,136; 5,245,022; 5,254,469; 5,258,506; 5,262,536; 5,272,250; 5,292,873; 5,317,098; 5,371,241, 5,391,723; 5,416,203, 5,451,463; 5,510,475; 5,512,667; 5,514,785; 5,565,552; 5,567,810; 5,574,142; 5,585,481; 5,587,371; 5,595,726; 5,597,696; 5,599,923; 5,599,928 and 5,688,941.
Locked Nucleic Acids (LNAs)
[0157] In some embodiments, the modified inhibitory nucleic acids (including ASOs) used in the methods described herein comprise locked nucleic acid (LNA) molecules, e.g., including [alpha]-L-LNAs. LNAs comprise ribonucleic acid analogues wherein the ribose ring is "locked" by a methylene bridge between the 2'-oxgygen and the 4'-carbon i.e., inhibitory nucleic acids containing at least one LNA monomer, that is, one 2'-O,4'-C-methylene-.beta.-D-ribofuranosyl nucleotide. LNA bases form standard Watson-Crick base pairs but the locked configuration increases the rate and stability of the basepairing reaction (Jensen et al., Oligonucleotides, 14, 130-146 (2004)). LNAs also have increased affinity to base pair with RNA as compared to DNA. These properties render LNAs especially useful as probes for fluorescence in situ hybridization (FISH) and comparative genomic hybridization, as knockdown tools for miRNAs, and as antisense oligonucleotides to target mRNAs or other RNAs, e.g., RNAs as described herein.
[0158] The LNA molecules can include molecules comprising 10-30, e.g., 12-24, e.g., 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 nucleotides in each strand, wherein one of the strands is substantially identical, e.g., at least 80% (or more, e.g., 85%, 90%, 95%, or 100%) identical, e.g., having 3, 2, 1, or 0 mismatched nucleotide(s), to a target region in the RNA. The LNA molecules can be chemically synthesized using methods known in the art.
[0159] The LNA molecules can be designed using any method known in the art; a number of algorithms are known, and are commercially available (e.g., on the interne, for example at exiqon.com). See, e.g., You et al., Nuc. Acids. Res. 34:e60 (2006); McTigue et al., Biochemistry 43:5388-405 (2004); and Levin et al., Nuc. Acids. Res. 34:e142 (2006). For example, "gene walk" methods, similar to those used to design antisense oligos, can be used to optimize the inhibitory activity of the LNA; for example, a series of inhibitory nucleic acids of 10-30 nucleotides spanning the length of a target RNA can be prepared, followed by testing for activity. Optionally, gaps, e.g., of 5-10 nucleotides or more, can be left between the LNAs to reduce the number of inhibitory nucleic acids synthesized and tested. GC content is preferably between about 30-60%. General guidelines for designing LNAs are known in the art; for example, LNA sequences will bind very tightly to other LNA sequences, so it is preferable to avoid significant complementarity within an LNA. Contiguous runs of more than four LNA residues, should be avoided where possible (for example, it may not be possible with very short (e.g., about 9-10 nt) inhibitory nucleic acids). In some embodiments, the LNAs are xylo-LNAs.
[0160] For additional information regarding LNAs see U.S. Pat. Nos. 6,268,490; 6,734,291; 6,770,748; 6,794,499; 7,034,133; 7,053,207; 7,060,809; 7,084,125; and 7,572,582; and U.S. Pre-Grant Pub. Nos. 20100267018; 20100261175; and 20100035968; Koshkin et al. Tetrahedron 54, 3607-3630 (1998); Obika et al. Tetrahedron Lett. 39, 5401-5404 (1998); Jepsen et al., Oligonucleotides 14:130-146 (2004); Kauppinen et al., Drug Disc. Today 2(3):287-290 (2005); and Ponting et al., Cell 136(4):629-641 (2009), and references cited therein.
Making and Using Inhibitory Nucleic Acids
[0161] The nucleic acid sequences used to practice the methods described herein, whether RNA, cDNA, genomic DNA, vectors, viruses or hybrids thereof, can be isolated from a variety of sources, genetically engineered, amplified, and/or expressed/ generated recombinantly. Recombinant nucleic acid sequences can be individually isolated or cloned and tested for a desired activity. Any recombinant expression system can be used, including e.g. in vitro, bacterial, fungal, mammalian, yeast, insect or plant cell expression systems.
[0162] Nucleic acid sequences of the invention can be inserted into delivery vectors and expressed from transcription units within the vectors. The recombinant vectors can be DNA plasmids or viral vectors. Generation of the vector construct can be accomplished using any suitable genetic engineering techniques well known in the art, including, without limitation, the standard techniques of PCR, oligonucleotide synthesis, restriction endonuclease digestion, ligation, transformation, plasmid purification, and DNA sequencing, for example as described in Sambrook et al. Molecular Cloning: A Laboratory Manual. (1989)), Coffin et al. (Retroviruses. (1997)) and "RNA Viruses: A Practical Approach" (Alan J. Cann, Ed., Oxford University Press, (2000)). As will be apparent to one of ordinary skill in the art, a variety of suitable vectors are available for transferring nucleic acids of the invention into cells. The selection of an appropriate vector to deliver nucleic acids and optimization of the conditions for insertion of the selected expression vector into the cell, are within the scope of one of ordinary skill in the art without the need for undue experimentation. Viral vectors comprise a nucleotide sequence having sequences for the production of recombinant virus in a packaging cell. Viral vectors expressing nucleic acids of the invention can be constructed based on viral backbones including, but not limited to, a retrovirus, lentivirus, adenovirus, adeno-associated virus, pox virus or alphavirus. The recombinant vectors capable of expressing the nucleic acids of the invention can be delivered as described herein, and persist in target cells (e.g., stable transformants).
[0163] Nucleic acid sequences used to practice this invention can be synthesized in vitro by well-known chemical synthesis techniques, as described in, e.g., Adams (1983) J. Am. Chem. Soc. 105:661; Belousov (1997) Nucleic Acids Res. 25:3440-3444; Frenkel (1995) Free Radic. Biol. Med. 19:373-380; Blommers (1994) Biochemistry 33:7886-7896; Narang (1979) Meth. Enzymol. 68:90; Brown (1979) Meth. Enzymol. 68:109; Beaucage (1981) Tetra. Lett. 22:1859; U.S. Pat. No. 4,458,066.
[0164] Nucleic acid sequences of the invention can be stabilized against nucleolytic degradation such as by the incorporation of a modification, e.g., a nucleotide modification. For example, nucleic acid sequences of the invention includes a phosphorothioate at least the first, second, or third internucleotide linkage at the 5' or 3' end of the nucleotide sequence. As another example, the nucleic acid sequence can include a 2'-modified nucleotide, e.g., a 2'-deoxy, 2'-deoxy-2'-fluoro, 2-O-methyl, 2'-O-methoxyethyl (2-O-MOE), 2'-O-aminopropyl (2-O-AP), 2'-O-dimethylaminoethyl (2'-O-DMAOE), 2'-O-dimethylaminopropyl (2'-O-DMAP), 2-O-dimethylaminoethyloxyethyl (2'-O-DMAEOE), or 2'-O--N-methylacetamido (2-O-NMA). As another example, the nucleic acid sequence can include at least one 2-O-methyl-modified nucleotide, and in some embodiments, all of the nucleotides include a 2-O-methyl modification. In some embodiments, the nucleic acids are "locked," i.e., comprise nucleic acid analogues in which the ribose ring is "locked" by a methylene bridge connecting the 2'-O atom and the 4'-C atom (see, e.g., Kaupinnen et al., Drug Disc. Today 2(3):287-290 (2005); Koshkin et al., J. Am. Chem. Soc., 120(50):13252-13253 (1998)). For additional modifications see US 20100004320, US 20090298916, and US 20090143326.
[0165] Techniques for the manipulation of nucleic acids used to practice this invention, such as, e.g., subcloning, labeling probes (e.g., random-primer labeling using Klenow polymerase, nick translation, amplification), sequencing, hybridization and the like are well described in the scientific and patent literature, see, e.g., Sambrook et al., Molecular Cloning; A Laboratory Manual 3d ed. (2001); Current Protocols in Molecular Biology, Ausubel et al., eds. (John Wiley & Sons, Inc., New York 2010); Kriegler, Gene Transfer and Expression: A Laboratory Manual (1990); Laboratory Techniques In Biochemistry And Molecular Biology: Hybridization With Nucleic Acid Probes, Part I. Theory and Nucleic Acid Preparation, Tijssen, ed. Elsevier, N.Y. (1993).
Pharmaceutical Compositions
[0166] The methods described herein can include the administration of pharmaceutical compositions and formulations comprising an inhibitory nucleic acid that targets PAR-TERRA RNA and other chromosome-specific TERRA RNAs.
[0167] In some embodiments, the compositions are formulated with a pharmaceutically acceptable carrier. The pharmaceutical compositions and formulations can be administered parenterally, topically, orally or by local administration, such as by aerosol or transdermally. The pharmaceutical compositions can be formulated in any way and can be administered in a variety of unit dosage forms depending upon the condition or disease and the degree of illness, the general medical condition of each patient, the resulting preferred method of administration and the like. Details on techniques for formulation and administration of pharmaceuticals are well described in the scientific and patent literature, see, e.g., Remington: The Science and Practice of Pharmacy, 21st ed., 2005.
[0168] The inhibitory nucleic acids can be administered alone or as a component of a pharmaceutical formulation (composition). The compounds may be formulated for administration, in any convenient way for use in human or veterinary medicine. Wetting agents, emulsifiers and lubricants, such as sodium lauryl sulfate and magnesium stearate, as well as coloring agents, release agents, coating agents, sweetening, flavoring and perfuming agents, preservatives and antioxidants can also be present in the compositions.
[0169] Formulations of the compositions of the invention include those suitable for intradermal, inhalation, oral/ nasal, topical, parenteral, rectal, and/or intravaginal administration. The formulations may conveniently be presented in unit dosage form and may be prepared by any methods well known in the art of pharmacy. The amount of active ingredient (e.g., nucleic acid sequences of this invention) which can be combined with a carrier material to produce a single dosage form will vary depending upon the host being treated, the particular mode of administration, e.g., intradermal or inhalation. The amount of active ingredient which can be combined with a carrier material to produce a single dosage form will generally be that amount of the compound which produces a therapeutic effect, e.g., an antigen specific T cell or humoral response.
[0170] Pharmaceutical formulations can be prepared according to any method known to the art for the manufacture of pharmaceuticals. Such drugs can contain sweetening agents, flavoring agents, coloring agents and preserving agents. A formulation can be admixtured with nontoxic pharmaceutically acceptable excipients which are suitable for manufacture. Formulations may comprise one or more diluents, emulsifiers, preservatives, buffers, excipients, etc. and may be provided in such forms as liquids, powders, emulsions, lyophilized powders, sprays, creams, lotions, controlled release formulations, tablets, pills, gels, on patches, in implants, etc.
[0171] Pharmaceutical formulations for oral administration can be formulated using pharmaceutically acceptable carriers well known in the art in appropriate and suitable dosages. Such carriers enable the pharmaceuticals to be formulated in unit dosage forms as tablets, pills, powder, dragees, capsules, liquids, lozenges, gels, syrups, slurries, suspensions, etc., suitable for ingestion by the patient. Pharmaceutical preparations for oral use can be formulated as a solid excipient, optionally grinding a resulting mixture, and processing the mixture of granules, after adding suitable additional compounds, if desired, to obtain tablets or dragee cores. Suitable solid excipients are carbohydrate or protein fillers include, e.g., sugars, including lactose, sucrose, mannitol, or sorbitol; starch from corn, wheat, rice, potato, or other plants; cellulose such as methyl cellulose, hydroxypropylmethyl-cellulose, or sodium carboxy-methylcellulose; and gums including arabic and tragacanth; and proteins, e.g., gelatin and collagen. Disintegrating or solubilizing agents may be added, such as the cross-linked polyvinyl pyrrolidone, agar, alginic acid, or a salt thereof, such as sodium alginate. Push-fit capsules can contain active agents mixed with a filler or binders such as lactose or starches, lubricants such as talc or magnesium stearate, and, optionally, stabilizers. In soft capsules, the active agents can be dissolved or suspended in suitable liquids, such as fatty oils, liquid paraffin, or liquid polyethylene glycol with or without stabilizers.
[0172] Aqueous suspensions can contain an active agent (e.g., nucleic acid sequences of the invention) in admixture with excipients suitable for the manufacture of aqueous suspensions, e.g., for aqueous intradermal injections. Such excipients include a suspending agent, such as sodium carboxymethylcellulose, methylcellulose, hydroxypropylmethylcellulose, sodium alginate, polyvinylpyrrolidone, gum tragacanth and gum acacia, and dispersing or wetting agents such as a naturally occurring phosphatide (e.g., lecithin), a condensation product of an alkylene oxide with a fatty acid (e.g., polyoxyethylene stearate), a condensation product of ethylene oxide with a long chain aliphatic alcohol (e.g., heptadecaethylene oxycetanol), a condensation product of ethylene oxide with a partial ester derived from a fatty acid and a hexitol (e.g., polyoxyethylene sorbitol mono-oleate), or a condensation product of ethylene oxide with a partial ester derived from fatty acid and a hexitol anhydride (e.g., polyoxyethylene sorbitan mono-oleate). The aqueous suspension can also contain one or more preservatives such as ethyl or n-propyl p-hydroxybenzoate, one or more coloring agents, one or more flavoring agents and one or more sweetening agents, such as sucrose, aspartame or saccharin. Formulations can be adjusted for osmolarity.
[0173] In some embodiments, oil-based pharmaceuticals are used for administration of nucleic acid sequences of the invention. Oil-based suspensions can be formulated by suspending an active agent in a vegetable oil, such as arachis oil, olive oil, sesame oil or coconut oil, or in a mineral oil such as liquid paraffin; or a mixture of these. See e.g., U.S. Pat. No. 5,716,928 describing using essential oils or essential oil components for increasing bioavailability and reducing inter- and intra-individual variability of orally administered hydrophobic pharmaceutical compounds (see also U.S. Pat. No. 5,858,401). The oil suspensions can contain a thickening agent, such as beeswax, hard paraffin or cetyl alcohol. Sweetening agents can be added to provide a palatable oral preparation, such as glycerol, sorbitol or sucrose. These formulations can be preserved by the addition of an antioxidant such as ascorbic acid. As an example of an injectable oil vehicle, see Minto (1997) J. Pharmacol. Exp. Ther. 281:93-102.
[0174] Pharmaceutical formulations can also be in the form of oil-in-water emulsions. The oily phase can be a vegetable oil or a mineral oil, described above, or a mixture of these. Suitable emulsifying agents include naturally-occurring gums, such as gum acacia and gum tragacanth, naturally occurring phosphatides, such as soybean lecithin, esters or partial esters derived from fatty acids and hexitol anhydrides, such as sorbitan mono-oleate, and condensation products of these partial esters with ethylene oxide, such as polyoxyethylene sorbitan mono-oleate. The emulsion can also contain sweetening agents and flavoring agents, as in the formulation of syrups and elixirs. Such formulations can also contain a demulcent, a preservative, or a coloring agent. In alternative embodiments, these injectable oil-in-water emulsions of the invention comprise a paraffin oil, a sorbitan monooleate, an ethoxylated sorbitan monooleate and/or an ethoxylated sorbitan trioleate.
[0175] The pharmaceutical compounds can also be administered by in intranasal, intraocular and intravaginal routes including suppositories, insufflation, powders and aerosol formulations (for examples of steroid inhalants, see e.g., Rohatagi (1995) J. Clin. Pharmacol. 35:1187-1193; Tjwa (1995) Ann. Allergy Asthma Immunol. 75:107-111). Suppositories formulations can be prepared by mixing the drug with a suitable non-irritating excipient which is solid at ordinary temperatures but liquid at body temperatures and will therefore melt in the body to release the drug. Such materials are cocoa butter and polyethylene glycols.
[0176] In some embodiments, the pharmaceutical compounds can be delivered transdermally, by a topical route, formulated as applicator sticks, solutions, suspensions, emulsions, gels, creams, ointments, pastes, jellies, paints, powders, and aerosols.
[0177] In some embodiments, the pharmaceutical compounds can also be delivered as microspheres for slow release in the body. For example, microspheres can be administered via intradermal injection of drug which slowly release subcutaneously; see Rao (1995) J. Biomater Sci. Polym. Ed. 7:623-645; as biodegradable and injectable gel formulations, see, e.g., Gao (1995) Pharm. Res. 12:857-863 (1995); or, as microspheres for oral administration, see, e.g., Eyles (1997) J. Pharm. Pharmacol. 49:669-674.
[0178] In some embodiments, the pharmaceutical compounds can be parenterally administered, such as by intravenous (IV) administration or administration into a body cavity or lumen of an organ. These formulations can comprise a solution of active agent dissolved in a pharmaceutically acceptable carrier. Acceptable vehicles and solvents that can be employed are water and Ringer's solution, an isotonic sodium chloride. In addition, sterile fixed oils can be employed as a solvent or suspending medium. For this purpose any bland fixed oil can be employed including synthetic mono- or diglycerides. In addition, fatty acids such as oleic acid can likewise be used in the preparation of injectables. These solutions are sterile and generally free of undesirable matter. These formulations may be sterilized by conventional, well known sterilization techniques. The formulations may contain pharmaceutically acceptable auxiliary substances as required to approximate physiological conditions such as pH adjusting and buffering agents, toxicity adjusting agents, e.g., sodium acetate, sodium chloride, potassium chloride, calcium chloride, sodium lactate and the like. The concentration of active agent in these formulations can vary widely, and will be selected primarily based on fluid volumes, viscosities, body weight, and the like, in accordance with the particular mode of administration selected and the patient's needs. For IV administration, the formulation can be a sterile injectable preparation, such as a sterile injectable aqueous or oleaginous suspension. This suspension can be formulated using those suitable dispersing or wetting agents and suspending agents. The sterile injectable preparation can also be a suspension in a nontoxic parenterally-acceptable diluent or solvent, such as a solution of 1,3-butanediol. The administration can be by bolus or continuous infusion (e.g., substantially uninterrupted introduction into a blood vessel for a specified period of time).
[0179] In some embodiments, the pharmaceutical compounds and formulations can be lyophilized. Stable lyophilized formulations comprising an inhibitory nucleic acid can be made by lyophilizing a solution comprising a pharmaceutical of the invention and a bulking agent, e.g., mannitol, trehalose, raffinose, and sucrose or mixtures thereof. A process for preparing a stable lyophilized formulation can include lyophilizing a solution about 2.5 mg/mL protein, about 15 mg/mL sucrose, about 19 mg/mL NaCl, and a sodium citrate buffer having a pH greater than 5.5 but less than 6.5. See, e.g., U.S. 20040028670.
[0180] The compositions and formulations can be delivered by the use of liposomes. By using liposomes, particularly where the liposome surface carries ligands specific for target cells, or are otherwise preferentially directed to a specific organ, one can focus the delivery of the active agent into target cells in vivo. See, e.g., U.S. Pat. Nos. 6,063,400; 6,007,839; Al-Muhammed (1996) J. Microencapsul. 13:293-306; Chonn (1995) Curr. Opin. Biotechnol. 6:698-708; Ostro (1989) Am. J. Hosp. Pharm. 46:1576-1587. As used in the present invention, the term "liposome" means a vesicle composed of amphiphilic lipids arranged in a bilayer or bilayers. Liposomes are unilamellar or multilamellar vesicles that have a membrane formed from a lipophilic material and an aqueous interior that contains the composition to be delivered. Cationic liposomes are positively charged liposomes that are believed to interact with negatively charged DNA molecules to form a stable complex. Liposomes that are pH-sensitive or negatively-charged are believed to entrap DNA rather than complex with it. Both cationic and noncationic liposomes have been used to deliver DNA to cells.
[0181] Liposomes can also include "sterically stabilized" liposomes, i.e., liposomes comprising one or more specialized lipids. When incorporated into liposomes, these specialized lipids result in liposomes with enhanced circulation lifetimes relative to liposomes lacking such specialized lipids. Examples of sterically stabilized liposomes are those in which part of the vesicle-forming lipid portion of the liposome comprises one or more glycolipids or is derivatized with one or more hydrophilic polymers, such as a polyethylene glycol (PEG) moiety. Liposomes and their uses are further described in U.S. Pat. No. 6,287,860.
[0182] The formulations of the invention can be administered for prophylactic and/or therapeutic treatments. In some embodiments, for therapeutic applications, compositions are administered to a subject who is need of reduced triglyceride levels, or who is at risk of or has a disorder described herein, in an amount sufficient to cure, alleviate or partially arrest the clinical manifestations of the disorder or its complications; this can be called a therapeutically effective amount. For example, in some embodiments, pharmaceutical compositions of the invention are administered in an amount sufficient to decrease serum levels of triglycerides in the subject.
[0183] The amount of pharmaceutical composition adequate to accomplish this is a therapeutically effective dose. The dosage schedule and amounts effective for this use, i.e., the dosing regimen, will depend upon a variety of factors, including the stage of the disease or condition, the severity of the disease or condition, the general state of the patient's health, the patient's physical status, age and the like. In calculating the dosage regimen for a patient, the mode of administration also is taken into consideration.
[0184] The dosage regimen also takes into consideration pharmacokinetics parameters well known in the art, i.e., the active agents' rate of absorption, bioavailability, metabolism, clearance, and the like (see, e.g., Hidalgo-Aragones (1996) J. Steroid Biochem. Mol. Biol. 58:611-617; Groning (1996) Pharmazie 51:337-341; Fotherby (1996) Contraception 54:59-69; Johnson (1995) J. Pharm. Sci. 84:1144-1146; Rohatagi (1995) Pharmazie 50:610-613; Brophy (1983) Eur. J. Clin. Pharmacol. 24:103-108; Remington: The Science and Practice of Pharmacy, 21st ed., 2005). The state of the art allows the clinician to determine the dosage regimen for each individual patient, active agent and disease or condition treated. Guidelines provided for similar compositions used as pharmaceuticals can be used as guidance to determine the dosage regiment, i.e., dose schedule and dosage levels, administered practicing the methods of the invention are correct and appropriate.
[0185] Single or multiple administrations of formulations can be given depending on for example: the dosage and frequency as required and tolerated by the patient, the degree and amount of therapeutic effect generated after each administration (e.g., effect on tumor size or growth), and the like. The formulations should provide a sufficient quantity of active agent to effectively treat, prevent or ameliorate conditions, diseases or symptoms.
[0186] In alternative embodiments, pharmaceutical formulations for oral administration are in a daily amount of between about 1 to 100 or more mg per kilogram of body weight per day. Lower dosages can be used, in contrast to administration orally, into the blood stream, into a body cavity or into a lumen of an organ. Substantially higher dosages can be used in topical or oral administration or administering by powders, spray or inhalation. Actual methods for preparing parenterally or non-parenterally administrable formulations will be known or apparent to those skilled in the art and are described in more detail in such publications as Remington: The Science and Practice of Pharmacy, 21st ed., 2005.
[0187] Various studies have reported successful mammalian dosing using complementary nucleic acid sequences. For example, Esau C., et al., (2006) Cell Metabolism, 3(2):87-98 reported dosing of normal mice with intraperitoneal doses of miR-122 antisense oligonucleotide ranging from 12.5 to 75 mg/kg twice weekly for 4 weeks. The mice appeared healthy and normal at the end of treatment, with no loss of body weight or reduced food intake. Plasma transaminase levels were in the normal range (AST 3/445, ALT 3/435) for all doses with the exception of the 75 mg/kg dose of miR-122 ASO, which showed a very mild increase in ALT and AST levels. They concluded that 50mg/kg was an effective, non-toxic dose. Another study by KrUtzfeldt J., et al., (2005) Nature 438, 685-689, injected anatgomirs to silence miR-122 in mice using a total dose of 80, 160 or 240 mg per kg body weight. The highest dose resulted in a complete loss of miR-122 signal. In yet another study, locked nucleic acids ("LNAs") were successfully applied in primates to silence miR-122. Elmen J., et al., (2008) Nature 452, 896-899, report that efficient silencing of miR-122 was achieved in primates by three doses of 10 mg kg-1 LNA-antimiR, leading to a long-lasting and reversible decrease in total plasma cholesterol without any evidence for LNA-associated toxicities or histopathological changes in the study animals.
[0188] In some embodiments, the methods described herein can include co-administration with other drugs or pharmaceuticals, e.g., compositions for providing cholesterol homeostasis. For example, the inhibitory nucleic acids can be co-administered with drugs for treating or reducing risk of a disorder described herein.
EXAMPLES
[0189] The invention is further described in the following examples, which do not limit the scope of the invention described in the claims.
Experimental Procedures
[0190] The following materials and methods were used in the Examples below.
[0191] FISH
[0192] Cells were cytospun onto glass slides and permeabilized with CSK buffer containing 0.5% Triton X-100, and fixed in 4% paraformaldehyde. DNA oligos probes for RNA FISH were ordered from Integrated DNA Technologies. For TERRA: (TAACCC).sub.7-Alexa488-3' and 5'-Cy5-(TAACCC).sub.7. For I4 oligos: I4-47 k 5'-Alexa488-TGC ACT GAC GTC CTG TGG CCA CTG GGT GGC GCC AGA GCAT (SEQ ID NO:7); I4-22 k: 5'-Cy3-taa tct gaa tat ctg ggc ctc cgt gtg cag acc tga ggt t (SEQ ID NO:8); 14 31 k: 5'-Cy5-gtc tct gtg tct gtc tct ctg tct ctg tcg cta act cta t (SEQ ID NO:9). DNA oligo probes for RNA-FISH were mixed at the final concentration 0.5 pmol/.mu.l in hybridization solution (50% formamide, 2.times.SSC, 2 mg/ml BSA, 10% Dextran Sulfate-500K). BAC DNA probes and PCR-PAR probes were labeled with fluorophore-dUTP using nick translation, used 1 ng/.mu.l for RNA-FISH and 50 ng/.mu.l for DNA FISH at the final concentration in hybridization buffer. Hybridization was carried out at 42.degree. C. overnight for RNA FISH. Slides were washed with 2.times.SSC/50% formamide for 5 min three times at 44.degree. C., and then wash with 2.times.SSC for 5 min twice at 44.degree. C. For DNA FISH, slides were treated with 0.4 mg/ml RNase A in PBS at 37.degree. C. for 1 hr, washed with PBS, incubated with 0.1 N HC1 for 10 min. Slides were washed in PBST (0.2% Tween 20 in 1.times.PBS) at RT for 5 mins, and then the denaturation was carried out in 70% formamide/2.times.SSC at 80.quadrature.C for 15 mins. Slides were then washed with PBS, dehydrated with EtOH, and air dried. Hybridization was carried out at 37.degree. C. overnight for DNA FISH, and washing condition was the same as for RNA-FISH with additional wash in 0.1.times.SSC for 5 min at 44.degree. C. For metaphase spread, cells were incubated with 50 ng/ml Colcemid for 2 hr, harvested, washed with PBS, incubated in cold 0.056M KCl on ice for 30 min and fixed in methanol/acetic acid (3:1). Metaphase spread chromosomes were spread on glass slides, air dried and fixed in 4% formaldehyde.
[0193] For pairing assay, digital images were obtained with the Nikon and processed using Volocity software (PerkinElmer). In brief, z sections were captured at 0.2 .mu.m intervals and 3D images were projected on a single two-dimensional plane. Distance of Xic-Xic, PAR-PAR (x), and the nuclear areas (A) was analyzed using Volocity software. Only nuclei with two resolvable X signals were scored (single dots were excluded). `Normalized distance` (ND) is defined as x/d, where d is the nuclear diameter, defined as 2(A/.pi.).sup.0.5. PCR-PAR PCR primer pairs were used as follows:
TABLE-US-00003 Primer Sequence SEQ ID NO: P3-F: CTCAGAGCCCAGTGTCAATCAC, 10 P3-R: CACGACCGCTTAGAAGAACCGG 11 P4-F: GAGACGGCCTACCATGTGCTTC, 12 P4-R: GTGAGTGCTGTGAACTCGGCTG 13 P5-F: CAGGGCCTGATTTGGCTTGAAAC 14 P5-R: GAAGAGTAGTCTGACCTCATCTC 15 P6-F: CAGGGCATGATATCCTCTTTGG 16 P6-R: CATTCAATGGTGTTGATGATGGTAC 17 P8-F: GGTTAGAATACAGCGCGGACATTCA 18 P8-R: GTGAATCTCCGAGGCAACTGTC 19
[0194] ChIRT-Seq Analysis
[0195] The PAR-TERRA ChIRT protocol was modified from the original ChIRP and CHART protocols (Chu et al., 2011; Simon et al., 2011) as follows: (i) We used a minimum number of capture probes to reduce off-target effects. (ii) We also increased the shearing size to 0.5-3 kb to preserve integrity of long noncoding RNAs. (iii) Because we observed that RNaseH is not active in SDS buffer, we used NP40 instead of SDS or N-lauroyl sarcosine in the final DNA elution; we used a lower concentration of NP40 detergent to better preserve RNaseH activity (FIG. 9A).
[0196] Specifically, mouse ES cells were grown to 80% confluency and feeder cells were removed. 15 millions of cells were spun down and washed with PBS once. Cells were resuspended in 10 ml of PBS and then another 10 ml of 2% of glutaraldehyde were added to fix cells at room temperature for 10 min. Crosslinking was then quenched with 0.125 M glycine for 5 min. Cells were than spun down at 2000 g for 5 min at 4.degree. C. Cells were then washed with cold PBS and then spun down again. Cell pellets were immediately frozen in liquid nitrogen and stored at -80.degree. C. Mouse ES cells at embryonic body stages (Day3, Day7) were trypsinized, filtered with cell strainers (40 .mu.m). The following steps were prepared as the same as undifferentiated ES cells. Cells were thaw out on ice, and were resuspened in 1 ml of swelling buffer (0.1 M Tris pH 7.0 10 mM KOAc, 15 mM MgOAc, 1% NP40, 1 mM DTT, 1 mM PMSF, 100 U/ml Superase-In[Ambion]) for 10 min on ice. Cells were then dounced and pelleted at 2500 g for 5 min. Nuclei was further lyzed in nuclear lysis buffer (50 mM Tris pH7.0, 10 mM EDTA, 1% SDS, 1 mM DTT, 1 mM PMSF, protease inhibitor, 100 U/ml Superase-In) on ice for 10 min, and sonicated using Bioruptor until DNA size 0.5-3 kb (it usually takes 1.5 hr and depends on the cell numbers). Cell lysates were then spun down at 13,000 rpm for 5 min to remove insoluble debris. Cell lysates were then frozen in liquid nitrogen and stored in -80.degree. C. Streptavidin-magnetic Cl (Life Technologies) beads were blocked with 500 ng/ul yeast total RNA, and 1 mg/ml BSA for 1 hr at 37.degree. C., and respuspended in 1.times. hybridization buffer (1 volume of lysis buffer plus 2 volume of 2.times. hybridization buffer). Cell lysates were diluted in two times volume of 2.times. hybridization buffer (750 mM NaCl, 1% SDS, 50 mM Tris pH 7.0, 1 mM EDTA, 15% Formamide, 1 mM DTT, PMSF, protease inhibitor, and 100 U/ml Superase-in), and were preclean with Streptavidin- magnetic Cl beads at 37.degree. C. for 1 hr (100 .mu.l of beads for 1 ml lysates). Precleaned lysates were incubated with pooled probes (100 pmol for 3 ml of diluted cell lysates) at 37.degree. C. for 3 hr. Three hundred microliters washed/blocked Cl beads were added per 100 pmol of probes, and the whole reaction was mixed for another 1 hr at 37.degree. C. DNA probes for ChIRT were ordered from Integrated DNA Technologies and labeled with 3' biotin-TEG. PAR DNA probe sequences were listed as follows:
TABLE-US-00004 36K; (SEQ ID NO: 20) gagcgcctcagtgtgcaaatct, 47K: (SEQ ID NO: 21) ACTGGGTGGCGCCAGAGCAT, 22K: (SEQ ID NO: 22) ctccgtgtgcagacctgaggtt, 34K: (SEQ ID NO: 23) ccctacctaccctccagaga, 31K: (SEQ ID NO: 24) tctctgtctctgtcgctaac. TERRA-AS probe sequence: (SEQ ID NO: 25) taaccctaaccctaacccta. TERRA-sense probe sequence: (SEQ ID NO: 26) TTAGGGTTAGGGTTAGGGTT.
[0197] Beads:biotin-probes:RNA:chromatin adducts were captured by magnets, washed five times at 37.degree. C. for 5 min with wash buffer (2.times.SSC, 0.5% SDS, 1 mM DTT, 1 mM PMSF), and then washed twice for 5 min at room temperature with 0.1% NP40 buffer (150 mM NaCl, 50 mM Tris pH8.0, 3 mM MgCl.sub.2, 10 mM DTT, 0.1% NP40). DNA was then eluted twice for 20 min in 450 .mu.l of 0.1% NP40 buffer with 200 U/ml RNase H (NEB) at room temperature. DNA for no RNase H controls was eluted in 0.1% NP40 buffer without RNaseH. Eluted DNA was treated with RNase A (1 mg/ml) at 37.degree. C. for 1 hr, and then was treated with proteinase K (1 mg/ml) and supplied addition of SDS to 0.5% at final concentration at 55.degree. C. for 16 hr. DNA was extracted with phenol/chloroform using phase lock gel tubes. For pre-RNaseA treatment control, cell lysates were treated with RNase A at 37.degree. C. overnight before hybridization. For RNA elution after hybridization, beads:biotin-probes:RNA:chromatin adducts were washed 5 time in wash buffer, then treated with proteinase K in PK buffer (100 mM NaCl, Tris pH 7.0, 1 mM EDTA, 0.5% SDS) at 55.degree. C. for 30 min. Beads suspension was boiled at 90.degree. C. for 5 min, and then RNA was extracted using TRIzol (Invitrogen). Primer pairs for q-PCR were used as followed:
TABLE-US-00005 PAR-DNA-F: (SEQ ID NO: 27) TGGAGGTTAAACGATTATTTATCTGC, PAR-DNA-R: (SEQ ID NO: 28) ACGAGTTTCCAAGGTGCTG; Hprt-F: (SEQ ID NO: 29) CTGCTACTTCAACTCCTGGTGTGC, Hprt-R: (SEQ ID NO: 30) AGGCGAATTGGGATGTAGCTCAG.
[0198] PAR-TERRA ChIRT-Seq Analysis
[0199] PicoGreen (Life Technologies) was used to estimate the concentration of eluted DNA. Before library construction, equal amount of lambda DNA (0.015 pg of PCR products, .about.250bp) was added as spike-in control into eluted DNA samples. The PCR primers sequences for lambda DNA are as follows: Lambda 5-F, 5'-GCA TAT GTT GTG TTT TAC AG-3' (SEQ ID NO:31); Lambda 5-R, 5'-GCA ACA AAT TGA TAA GCA-3' (SEQ ID NO:32). Following the removal of adaptor sequences and PCR duplicates, paired-end 50 bp sequencing data was aligned to mouse reference genome (GRCm38/mm10 and NCBI37/mm9) using the software Novoalign (v3.00.02) (Li H. (2013) Aligning sequence reads, clone sequences and assembly contigs with BWA-MEM. arXiv:1303.3997v1 [q-bio.GN]) . The coverage files were generated using R software library SPP software (Kharchenko et al., 2008) with smoothing using 500 bp bins with a 100 bp step size to generate control-subtracted, normalized read densities. Controls include input, sense-ChIRT, and TERRA-ChIRT without RNase H elution (no RNase H). These data were visualized using IGV software to display all tracks with a mean windowing function and scales indicated in each figure. Other methods to generate normalized coverage files, including the generation of conservative enrichment and maximum likelihood estimates, resulted in similar distribution patterns. Scatter plots for correlation analysis used input-normalized coverage produced by SPP, windowed by 3 kb bins and filtered out unenriched bins with an averaged density smaller than 4. Peaks were called by MACS (1.4.2)(Zhang et al., 2008) software using normalization to indicated controls (e.g., input, sense, no RNaseH or pre-RNaseA), and filtered by peak length greater than 1 kb. Metagene profiles were produced by software CEAS (0.9.9.7) (Shin et al., 2009) using 2 fold enriched over input wig files and bed files produced by MACS peak calling.
[0200] TERRA Knockdown
[0201] Mouse ES cells (female, 16.7, cas/mus hybrid) were grown to 70% confluency, and then trypsinized, and feeder cells were removed. A total of 2.times.10.sup.6 mES cells were transfected with LNA gapmer oligos at a concentration of 2.about.8 .mu.M in 100 .mu.l nucleuofector solution using A30 program (nucleuofector kits, Lonza). A total of 2 ml of feeders-conditional medium (medium from feeders grown in mES medium for 6-18 hr) was added to the cells, and the cells were plated on gelatinized plates. LNA gapmers were designed and synthesized by Exiqon with modified LNA bases and phosphothiolated backbone modification. The LNA sequences were as follows: Scr, 5'-CAC GTC TAT ACA CCA C-3' (SEQ ID NO:4); TERRA, 5'-TAA CCC TAA CCC TAA C-3' (SEQ ID NO:5); PAR, 5'-TCT CTG TCT CTG TCG C-3' (SEQ ID NO:6). SV40T transformed MEFs (cas/mus hybrid) were used for TERRA LNA knockdown.
[0202] RNA-Seq Analysis
[0203] Total RNA was isolated using TRIzol (Invitrogen), depleted of DNA by DNase treatment (TURBO DNase, Ambion), depleted of ribosomal RNA (Ribominus Eukaryote Kit v2, Invitrogen), purified greater than 200 nucleotides using mirVana RNA extraction kit (Ambion), and fragmented in first strand synthesis buffer (NEB) containing magenisium at 95.degree. C. for 10 min to a median size 150-200 bp. cDNA were reversed transcribed with random primers (with Actinomycin D) using Superscript III (Invitrogen) at 50.degree. C. for 30 min. The following steps such as second strand synthesis, end repaired, dA-tailing, adaptor ligation, USER enzyme digestion, double size selection (0.6.times.-1.2.times. AMpure XP beads), and library amplification were performed according to NEBUltra Directional RNA library preparation protocol for Illumina (NEB). Sequencing of purified libraries was carried out on an Illumina HiSeq instrument for paired 50 nucleotides reads. After removal of adaptor sequences by Trim Galore, reads were aligned to mouse genomes (GRCm38/mm10 and NCBI37/mm9) using Tophat2. After removal of PCR duplicates, data was analyzed using either Cuffdiff 2 (Trapnell et al., 2013). Differential expression was called using Cuffdiff 2 with a threshold of q-Value <0.05. Coverage of RNA-seq was normalized by per million mapped reads as FPM value shown in the tracks. Allelic RNA-seq analysis was described previously (Simon et al., 2013). Briefly, reads were aligned to allele-specifically to 129S1/SvJm (mus) and CAST/EiJ (cas) using Tophat2. All reads mapping to gene bodies were summed for cas, mus and comp tracks, and PCR duplicates were removed. Differential expression between sets of genes in KD samples was analyzed using R library EdgeR (3.4.2) within by HOMER (4.8) software (Heinz et al., 2010) using function analyseRepeates.pl to generate count numbers on mus tracks for gene expression on Xi (mus).
[0204] Northern Blotting Analysis
[0205] DNA sequences for Northern probes were listed as follows:
TABLE-US-00006 SEQ Probe Sequence ID NO. TERRA TAACCCTAACCCTAACCCTAACCCTAACCC 33 GAPDH GTAGACCCACGACATACTCAGCACCGGCCT 34 CACCCCATT I4-15k aaggccagccgcggttccagacctgcggtg 35 cggccgtgtc I4-22k taatctgaatatctgggcctccgtgtgcag 36 acctgaggtt I4-27k ttgggggcgtgtctcagagcaggaggggtg 37 tggtctggca I4-31k gtctctgtgtctgtctctctgtctctgtcg 38 ctaactctat I4-34k aaagccaccaggcctctaatccctacctac 39 cctccagaga I4-42k cctggagaaatcaagtctgcgaagatccaa 40 aaattaaaat I4-47k TGCACTGACGTCCTGTGGCCACTGGGTGGC 41 GCCAGAGCAT I4-53k CTGACCACCAGGCTACAGTGTCCTGTAACC 42 GCCAGGCATA
[0206] All oligo probes were end labeled using T4 polynucleotide kinase. 14-31 k oligos were used for PAR-TERRA transcripts in FIG. 4B. Total RNA was extracted using TRIzol followed by acid phenol extraction. Total RNA (5 .mu.g) was loaded in each lane. Hybridization was carried out at 42.degree. C. overnight using ULTRAhyb-Oligo hybridization buffer (Ambion).
[0207] Quantitative RT-PCR
[0208] Total RNA was isolated using TRIzol (Invitrogen), treated with TURBO DNase (Ambion), and reverse-transcribed with random primers using Superscript III reverse transcriptase (Invitrogen). qRT-PCR was perform using iQ SYBR Green Supermix (Bio-Rad). Expression levels were normalized to GAPDH levels. Primer pairs were used as follows:
TABLE-US-00007 Primer Sequence SEQ ID NO: GAPDH-F CGTCCCGTAGACAAAATGGT 43 GAPDH-R TTGATGGCAACAATCTCCAC 44 Erdr1-F CACAGTGATGTCACCCACGA 45 Erdr1-R GTGAGAATCGCTCCGTCCTG 46 Mid1- GGACGAGAGGGGACAAAGGA 47 intron1-F Midi- GGTCAAACCTGGACTCTGGCA 48 intron1-R Asmt-F GAAGTGGGACAGGAAGTGAG 49 Asmt-R CGGGAACAGGAAGTGGC 50 Wls-F CCAGTCTAATGGTGACCTGGG 51 Wls-R TGAGAGTCAGCATGCACCAG 52 Tmx3-F TACCGAGGACCACGGACTAA 53 Tmx3-R AATACACGGTGCCTCTTCCG. 54
[0209] XIST CHART-Seq Analysis
[0210] The Xist CHART was modified from the original XIST CHART protocols (Simon et al., 2011). We used 7 oligo probes to target Xist RNA:
TABLE-US-00008 Oligo Sequence SEQ ID NO: Xist-503 CAGGTATCCATGGCCCCGATGGGC 55 Xist-1895 CTCGGTCTCTCGAATCGGATCCGAC 56 Xist-3322 GAGTTATGGGCACTGCATTTTAGCA 57 Xist-5799 TTGTTAAACGCAGGCTAGATCCTGA 58 mXist-1240 CGCCATTTTATAGACTTCTGAGCAG 59 mXist-935 CCtaattcttggcgtaactggctcg 60 mXist-5651 ATGCTTAGGAAGAGGGACAAATGCA 61
[0211] In detail, 20 million cells were crosslinked by with 1% formaldehyde for 10 min at room temperature. Crosslinking was then quenched with 0.125 M glycine for 5 min. After washing 3 times with PBS, crosslinked cells were re-suspended in 2 ml of sucrose buffer (0.3 M sucrose, 1% Triton-X-100, 10 mM HEPES pH 7.5, 100 mM KOAc, 0.1 mM EGTA), dounced 20 times with a tight pestle, and kept on ice for 10 min. The following steps were using polystyrene tubes,glass pipettes, and DNA LoBind microtubes (Eppendorf) to avoid cell clumps sticking onto the walls of tubes or pipettes. Nuclei were collected by centrifugation at 1,500 g for 10 min on top of a cushion of 5 ml glycerol buffer (25% glycerol, 10 mM HEPES pH7.5, 1 mM EDTA, 0.1 mM EGTA, 100 mM KOAc). Nuclei were further crosslinked with 3% formaldehyde for 30 min at room temperature. After washing three times with PBS, nuclei were extracted once with 50 mM HEPES pH7.5, 250 mM NaCl, 0.1 mM EGTA, 0.5% N-lauroylsarcosine, 0.1% sodium deoxycholate, 5 mM DTT, 100 U ml21 SUPERasIN (Invitrogen) for 10 min on ice, and centrifuged at 400g for 5 min at 4 uC. Nuclei were resuspended in 270 .mu.l of sonication buffer (50 mM HEPES pH 7.5, 75 mM NaCl, 0.1 mM EGTA, 0.5% N-lauroylsarcosine, 0.1% sodium deoxycholate, 5 mM DTT, 10 U/ml SUPERasIN, and sonicated in microtubes using Covaris S2 sonicator at 10% duty cycle, 200 bursts per cycle, intensity 3 for 5 min. The size of chromatin fragments was 0.2.about.3 kb. Fragmented chromatin was subjected to hybridization immediately. Hybridization, washing and elution were performed similarly to TERRA-ChIRP protocol. In brief, beads were blocked by yeast tRNA and BSA. 320 .mu.l of 2.times. hybridization buffer (750 mM NaCl, 1% SDS, 50 mM Tris pH to 7.0, 1 mM EDTA, 15% Formamide, 1 mM DTT, PMSF, protease inhibitor, and 100 U/ml Superase-in) was added into 160 .mu.l lysates, and then this 1.times. hybridization lysate was precleaned by 60 .mu.l of blocked beads at room temperature for 1 hr. After removal of the beads, 7 probes (labeled with 3' biotin-TEG) for Xist RNA (3.66 pmol/per probe) were added into the 1.times. hybridization lysate and incubate at room temperature for overnight. Beads:biotin-probes:RNA:chromatin adducts were captured by magnets, washed once with 1.times. hybridization buffer at 37.degree. C. for 10 min, washed four times at 37.degree. C. for 5 min with wash buffer (2.times.SSC, 0.5% SDS, 1 mM DTT, 1 mM PMSF), and then washed twice for 5 min at room temperature with 0.1% NP40 buffer (150 mM NaCl, 50 mM Tris pH8.0, 3 mM MgC12, 10 mM DTT, 0.1% NP40). DNA was then eluted twice for 20 min in 450 .mu.l of 0.1% NP40 buffer with 200 U/ml RNase H (NEB) at room temperature.
[0212] Metagene Analysis
[0213] Escapee genes are as previously described (Carrel and Willard, 2005; Yang et al., 2010; Pinter et al., 2012). Xist itself is excluded as an escapee in the metagene analysis. "Repressed" genes are all other genes on the Xi which have an FPKM>1.0 on the Xa. The normalized coverage files produced from SPP were used for metagene analysis with CEAS software.
Example 1. Identification of Sex-Linked PAR-TERRA Transcripts
[0214] RNA fluorescence in situ hybridization (FISH) using TERRA oligo probes showed that TERRA can be seen, in high-exposure and higher contrast images, as multiple foci in the nuclei of ES cells (FIG. 1A). Consistent with our previous report (Zhang et al., 2009), two of the speckles were especially prominent. To confirm their colocalization next to the sex chromosomes, we performed serial RNA-DNA FISH using probes from the pseudoautosomal region (PAR) of the sex chromosomes. The PAR represents the only homologous region between chromosomes (Chr) X and Y. Because PAR genes are shared between the sex chromosomes, these genes are not subject to XCI. At the commencement of this project, the most distally mapped X-and Y-linked gene was the PAR gene, Mid1 (Erdr1 and Asmt were partially assembled in recent months). We obtained two BAC clones mapping to Mid1--the 15 kb BAC RP24-143B12 and the .about.146 kb RP24-500I4. RP24-500I4 contains several internal telomeric repeats, two of 40 bp and the third of 314 bp (FIG. 1B). To isolate PAR-specific probes, we subcloned the BACs, generated unique PCR fragments, and identified a set of unique probes consistenting of P3, P4, P5, P6, and P8 (P34568; FIG. 8A,B). Serial RNA-DNA FISH showed that the large TERRA foci indeed mapped to the PAR in ES cells. Quantitation of RNA FISH intensities indicated that sex chromosome-associated TERRA RNA accounted for .about.80-90% of total TERRA transcripts and the finer speckles .about.10-20% of detected signals (FIG. 1A,C).
[0215] Although cytological analysis shows that TERRA RNA localizes to the ends of most, if not all chromosomes (Azzalin et al., 2007; Schoeflner and Blasco, 2008), the origin of TERRA transcription is not fully known. TERRA may be transcribed by all telomeres and retained in cis, or it may be transcribed by only a few loci but localized in trans to multiple distant sites. A murine transcriptomic study indicates that TERRA is synthesized predominantly from the end of Chr18 (de Silanes et al., 2014). Because sub-telomeric sequences of some chromosomes, including Chr X and Y, have not been fully sequenced or assembled, determining additional transcriptional origins for TERRA is possible.
[0216] To determine whether the sub-telomeric region of ChrX and ChrY could contribute to sex-linked TERRA transcription, we carried out RNA FISH to compare signals arising from PAR versus TERRA probes. The PAR and TERRA RNA clusters looked nearly identical in male and female ES cells (FIG. 1D,E), raising the possibility that PAR and TERRA may extend--at least in a fraction of total transcription--as a single long noncoding RNA. On Northern blot analyses, an antisense TERRA oligo probe detected a smear of signals from 100 bp to >9 kb (FIG. 1F, left panel), consistent with TERRA being of heterogeneous size (Azzalin et al., 2007; de Silanes et al., 2014). However, we observed a dominant species in ES cells of >>9 kb, indicating that some TERRA transcripts may originate much further upstream in relation to the telomeric repeats. Primer extension using an antisense TERRA oligo probe gave positive amplification by RT-PCR using PAR-specific primer pairs located at 33, 36, and 39 kb from the end of BAC RP24-500I4 (FIG. 1F, right panel), demonstrating that PAR-initiated RNAs is physically contiguous with at least a fraction of TERRA-containing RNA. We then repeated Northern analysis using sub-BAC walking probes to verify the physical contiguity and observed smears of high molecular weight transcripts similar to those observed with TERRA probes (FIG. 1F,G). The pattern was especially similar with probes 22k, 27k, 34k, 36k, and 47k. Two-color RNA FISH using BAC sub-probes showed that >90% of large RNA clusters were coincident with TERRA foci in ES cells (FIG. 1H) as well as in MEF (FIG. 8C). In MEFs, .about.93% of PAR and TERRA clusters (n=285) localized next to, but generally did not overlap with, the Xist cloud (FIG. 8D). Henceforth, we refer to the TERRA transcripts of PAR origin as "PAR-TERRA", to distinguish them from TERRA transcripts intrinsic to the TTAGGG repeats and to those originating within sub-telomeric regions of autosomes.
[0217] TERRA foci were similarly observed in various human cells (FIG. 8C). In mice, PAR-TERRA expression showed some strain-specific variation. For example, PAR-TERRA signals were detectable with the 22 k probe in hybrid ES and MEF cells of mixed Mus musculus (mus) and Mus castaneus (cas) origin. Using the 22 k probe, however, PAR-TERRA could not be detected in cells of pure musculus origin (FIG.
[0218] 8E). This is consistent with the PAR being variable in sequence between mouse strains (Soriano et al., 1987). As a consequence, the two large TERRA foci were often asymmetric in size in hybrid 16.7 female ES cells, with Mus musculus cluster being smaller than the Mus castaneus cluster. In J1 male ES cells, TERRA RNAs on both Chr X and Y were usually smaller, consistent with their being of Mus musculus origin. We conclude that a substantial fraction of sex-linked TERRA transcripts originates in the pseudoautosomal region (PAR-TERRA). The X-linked origin could have been missed previously (de Silanes et al., 2014) because pseudoautosomal sequences and assembly were not available until recently.
Example 2. Mapping Genome-Wide Targets of TERRA and PAR RNA By ChIRT-Seq
[0219] Although RNA FISH showed that >90% localized in cis to Chr X and Y, additional foci throughout the nucleus were clearly evident (FIG. 1H). Because the probes were PAR-specific, this finding indicated that PAR-TERRA could diffuse away from the sex chromosomes and possibly localize elsewhere in the nucleus. To identify genome-wide targets of TERRA and PAR RNA, we captured RNA-bound genomic sites by merging elements of ChIRP (Chu et al., 2011) and CHART (Simon et al., 2011) to achieve high specificity of chromatin pulldown (henceforth "ChIRT").
[0220] Because capture probes could potentially interact with DNA rather than RNA, we included an RNaseH elution step (FIG. 9A). Several DNA-based capture probes were designed: (i) TERRA antisense (TERRA-AS), to capture transcripts containing UUAGGG, (ii) PAR, to capture PAR-TERRA transcripts, and (iii) TERRA sense (TERRA-S, the reverse complement), to control for background. Slot blot analysis showed that both TERRA-AS and 31 k-PAR-AS probes captured TERRA RNA after ChIRT, whereas the corresponding sense probes did not (FIG. 2B). Quantitative PCR indicated that PAR sequences were enriched relative to Hprt sequences after ChIRT using TERRA-AS and PAR-AS probes, but not when the TERRA-S probe was used (FIG. 2C). The enrichment was dependent on RNaseH treatment and was abolished by RNase A treatment (FIG. 2D), indicating that the pulldown was mediated by interaction between the DNA capture probes and RNA targets.
[0221] We then performed deep sequencing of ChIRT-seq pulldowns to identify genome-wide binding sites. To rule out artifacts due to direct probe hybridization to genomic DNA rather than the intended RNA target, we sequenced two critical controls: (i) an RNaseH- control in which RNaseH was omitted in the elution step, which would in principle preclude elution of RNA-dependent interactions; and (ii) a TERRA-S control, which would not hybridize to TERRA RNA but could potentially pull down contaminating DNA (in addition to any potential antisense-TERRA transcripts). We collected ES cells on differentiation days 0, 3, 7 (d0, d3, d7) and MEFs for ChIRT-seq. Approximately 30 million 50-bp paired-end reads were obtained for each library. After removing PCR duplicates, >70% of reads uniquely mapped to the mouse genome. Biological replicates showed a high degree of correlation (FIG. 9B,C).
[0222] We used MACS software to call statistically significant enrichment peaks signifying genomic binding sites of TERRA and PAR transcripts (FIG. 2E). To call enrichment peaks, we normalized ChIRT reads to (i) input library, (ii) TERRA-S library, or (iii) no-RNaseH library. The results were highly similar with each method of normalization (FIG. 2F), and MACS called a similar number of peaks (FIG. 2E). Major enrichment at telomeric repeat DNA in the TERRA-AS pulldown relative to TERRA-S and no-RNaseH controls provided a validation of our ChIRT method (FIG. 2G). Across the genome, we observed >2,000 peaks of TERRA binding in day 0 and day 3 ES cells, .about.1,800 peaks in d7 differentiating ES cells, and .about.500 peaks in MEFs (FIG. 2E). Peaks called in the sense ChIRT samples did not overlap those called for TERRA or PAR (FIG. 2F), and could represent either background or binding of a putative antisense TERRA transcript. Similarly for PAR RNA, we observed thousands of binding sites in ES cells and hundreds in MEFs. Overall, PAR-TERRA to binding sites were enriched in noncoding space, including upstream regulatory regions, introns, and intergenic space, whereas binding in exons was depleted (FIG. 2H,I).
[0223] There was considerable overlap between TERRA and PAR ChIRT profiles, with high Pearson's r values in correlation plots for d0 and d3 ES cells and for MEFs, but not for comparisons to sense-ChIRT controls (FIG. 2F). There was also a high degree of similarity between biological replicates (FIG. 9B,C). In ES cells and MEFs, whole-genome views demonstrated strongest overall enrichment of both TERRA and PAR RNAs at telomeric ends, inclusive of sub-telomeric regions--regions with unique sequence that enabled unambiguous alignment of paired-ends TERRA reads to the specific chromosome ends (FIG. 3A). Intriguingly, the X-linked RNAs could diffuse to autosomes and bind their telomeric ends (FIG. 3A, PAR track). In MEFs, the number of TERRA and PAR targets decreased overall, but telomeric ends remained enriched. Control TERRA-S pulldowns did not resemble TERRA-AS pulldowns and showed no significant enrichment at telomeres. These results demonstrated the specificity of the TERRA and PAR pulldowns and argued against artifacts of genomic DNA hybridization. Taken together, our findings demonstrate that telomeric RNAs (i) are indeed produced from the sex chromosomes and (ii) bind both in cis and in trans to their site of synthesis.
[0224] Table 1 provides a list of X-linked genes with the highest PAR-TERRA binding. Top binders are defined as the top quartile in terms of PAR-TERRA density over the gene. There are 452 active genes in the MEF cell line. Mm10 coordinates are used. Start and stop positions of the gene target, along with the gene name and transcribed strand are shown. RNA-seq FPKM refers to gene expression in frequency per kilobase per million reads. Mean TERRA coverage over the gene is also shown.
TABLE-US-00009 TABLE 1 PAR-TERRA binding sites on the mouse X-chromosome in MEFs Mean of mm10 TERRA assembly Start End gene name FPKM strand coverage chrX 169685246 169990797 Mid1 1.39743 + 203.232 chrX 169311530 169320343 Hccs 27.2857 - 64.2334 chrX 167207093 167209218 Tmsb4x 454.052 - 24.1368 chrX 152336851 152342484 Tspyl2 28.3268 - 13.6914 chrX 166499814 166510478 Tceanc 2.77384 - 13.1733 chrX 74270815 74273135 Rpl10 82.0002 + 12.988 chrX 74270815 74273135 Snora70 201.378 + 12.988 chrX 74273216 74282333 Dnase1l1 1.20938 - 12.9053 chrX 134601285 134607054 Hnrnph2 44.022 + 11.0383 chrX 74369218 74373349 Slc10a3 10.7721 - 10.2314 chrX 153498231 153501558 Ubqln2 81.5338 + 10.2078 chrX 73673132 73682500 Slc6a8 57.6063 + 10.028 chrX 168795098 169304435 Arhgap6 1.7761 + 9.93581 chrX 134588168 134601005 Gla 10.9353 - 9.78217 chrX 168654117 168673902 Msl3 7.40496 - 9.71429 chrX 134686518 134697772 Armcx4 9.21521 + 9.7044 chrX 152233229 152274354 Kdm5c 101.365 + 9.38192 chrX 101449108 101453541 Itgb1bp2 1.18288 + 8.99717 chrX 101429650 101448593 Nono 123.217 + 8.59172 chrX 74313032 74320149 Fam50a 52.844 + 8.43926 chrX 94636068 94638561 Gspt2 18.0414 + 8.38342 chrX 166457251 166479867 Rab9 44.5493 - 8.34863 chrX 74282696 74290151 Taz 20.6918 + 8.29363 chrX 99136129 99148991 Efnb1 8.80092 + 8.27655 chrX 152004583 152016295 Ribc1 8.85901 - 8.25976 chrX 101254527 101260873 Foxo4 35.4845 + 7.89614 chrX 152144267 152225236 Iqsec2 3.55372 + 7.89114 chrX 13281021 13293983 Ddx3x 202.014 + 7.79031 chrX 74365717 74368548 Ubl4 27.821 - 7.72789 chrX 152001895 152004442 Hsd17b10 58.1856 + 7.67299 chrX 101532734 101601789 Taf1 47.7176 + 7.64038 chrX 152016427 152061973 Smc1a 57.1067 + 7.62341 chrX 152294827 152327493 2900056M20Rik 1.73042 - 7.3519 chrX 150571506 150588149 Apex2 30.0146 - 7.27157 chrX 151803281 151935417 Huwe1 161.224 + 7.14147 chrX 20688492 20699877 Cdk16 89.5491 + 6.96555 chrX 101404383 101420685 Zmym3 53.5806 - 6.93208 chrX 103560909 103623754 Ftx 6.13111 - 6.83641 chrX 134748454 134751419 Armcx6 1.47279 - 6.69088 chrX 8061170 8074760 Suv39h1 10.5102 - 6.59123 chrX 109095406 109162467 Sh3bgrl 11.0008 + 6.35196 chrX 94535473 94542074 Maged1 150.771 - 6.24733 chrX 96096044 96168553 Msn 125.765 + 6.23976 chrX 73483634 73495936 Bgn 131.985 + 6.19272 chrX 163909159 163929546 Ap1s2 22.2628 + 6.12689 chrX 106015699 106022450 Cox7b 81.8186 + 6.02631 chrX 74013913 74023936 Irak1 54.9015 - 5.97292 chrX 74013913 74023936 Mir5132 28310 - 5.97292 chrX 166523006 166585716 Egfl6 2.75673 - 5.89232 chrX 101274090 101298934 Med12 16.9166 + 5.74426 chrX 74223460 74246534 Flna 119.321 - 5.66957 chrX 139779680 139782353 Ripply1 9.2593 - 5.66923 chrX 94188708 94212651 Eif2s3x 13.3916 - 5.62242 chrX 140539528 140600522 Tsc22d3 4.01031 - 5.60397 chrX 74254838 74257747 Emd 131.791 + 5.52669 chrX 94074630 94123407 Zfx 14.4577 - 5.457 chrX 8138974 8147963 2900002K06Rik 2.48279 + 5.45401 chrX 8138974 8147963 Rbm3 21.0491 - 5.45401 chrX 151047232 151096543 Fgd1 81.8043 + 5.44937 chrX 151047232 151096543 Tsr2 23.1259 - 5.44937 chrX 57383347 57393036 Rbmx 15.7016 - 5.4457 chrX 73916869 73921944 Naa10 94.1038 - 5.41574 chrX 74297096 74304721 Atp6ap1 57.5415 + 5.33398 chrX 100622905 100625907 Pdzd11 67.6827 - 5.24963 chrX 166440824 166452543 Trappc2 5.95827 + 5.23482 chrX 101640063 101684351 Ogt 82.85 + 5.19793 chrX 74329065 74344689 Plxna3 6.81077 + 5.15815 chrX 73716596 73738287 Abcd1 9.8525 + 5.05484 chrX 7884243 7894492 Slc35a2 8.80274 + 5.05244 chrX 7919821 7928607 Eras 53.4302 - 5.03256 chrX 7919821 7928607 Pcsk1n 14.3249 + 5.03256 chrX 73437314 73459029 Haus7 37.766 - 5.03236 chrX 7894518 7899269 Pqbp1 101.762 - 4.95918 chrX 140948424 140956711 Psmd10 16.0633 - 4.86065 chrX 160502165 160598878 Phka2 10.5119 + 4.82787 chrX 159627407 159975917 Sh3kbp1 13.5148 + 4.81242 chrX 9654269 9662983 Dynlt3 8.16616 - 4.77036 chrX 60891365 60893430 Sox3 5.66273 - 4.76974 chrX 73778962 73786897 Idh3g 186.084 - 4.72145 chrX 142317992 142390535 Acsl4 25.1009 - 4.71533 chrX 164373547 164402647 Figf 2.67737 + 4.70077 chrX 7823842 7836503 Kcnd1 5.67212 + 4.6921 chrX 163935442 163958666 Zrsr2 32.212 - 4.68589 chrX 159372194 159385699 Eif1ax 160.42 + 4.667 chrX 150983132 151017322 Gnl3l 79.5544 - 4.63998 chrX 7722248 7728201 Wdr45 57.6147 + 4.57451 chrX 7762660 7775202 Tfe3 88.3365 + 4.55791 chrX 101377336 101385624 Gjb1 7.30102 + 4.55117 chrX 155213138 155216409 Sat1 31.7602 - 4.49062 chrX 164419786 164433915 Piga 14.5205 + 4.46376 chrX 73686182 73716175 Bcap31 136.655 - 4.34133 chrX 7728570 7731063 Praf2 45.3074 + 4.32855 chrX 136139044 136140437 Bex4 54.8305 + 4.31599 chrX 134585653 134588062 Rpl36a 1.66059 + 4.30142 chrX 134804141 134809221 Armcx2 20.2464 - 4.29013 chrX 73853779 73880834 L1cam 1.33532 - 4.26027 chrX 58030627 58036630 Zic3 68.0886 + 4.24685 chrX 159532667 159593081 A830080D01Rik 43.9242 + 4.19267 chrX 7899397 7907652 Timm17b 31.5895 + 4.06939 chrX 142853473 142966728 Ammecr1 13.3866 - 4.01434 chrX 164070702 164076049 Siah1b 49.6673 - 3.99607 chrX 150806420 150814339 Maged2 15.8384 - 3.94816 chrX 100626064 100727271 Kif4 34.3476 + 3.93177 chrX 75095853 75130949 Dkc1 136.814 + 3.90988 chrX 75095853 75130949 Mpp1 38.769 - 3.90988 chrX 37091833 37110322 Upf3b 39.8344 - 3.88822 chrX 12936872 12938541 AA414768 7.27643 + 3.8628 chrX 48411048 48463132 Elf4 16.0656 - 3.8481 chrX 7959259 7967910 Gata1 1.29963 - 3.77677 chrX 134308162 134362639 Cenpi 16.8886 + 3.77197 chrX 134059348 134086821 Cstf2 45.5011 + 3.75403 chrX 51003913 51018018 Rap2c 14.0536 - 3.69198 chrX 8238667 8252406 Ftsj1 29.4 - 3.68661 Top 25% of TERRA mean coverage over gene Total active gene 452
Example 3. PAR-TERRA Localizes in Cis and In Trans
[0225] Although TERRA and PAR ChIRT profiles were very similar, ChIRT analysis revealed heterogeneity in the telomeric RNAs. Some binding sites were dominated by TERRA RNA (e.g., telomeric ends of Chr 3,4,5, etc), while others showed prominent peaks of both TERRA and PAR RNA (FIG. 3). A distinct PAR-TERRA species was further supported by the nearly identical ChIRT profiles at these sites of overlap to (examples shown in FIG. 3B-D), as well as by the above molecular analyses indicating a physical contiguity (FIG. 1F,G). PAR-TERRA binding was especially notable at the subtelomeric end (pseudoautosomal region) of the sex chromosomes (FIG. 3B). Mid 1, Erdr 1 , and Asmt are tens of kilobases away from the TERRA DNA sequence [(TTAGGG)n telomeric repeat], but nevertheless demonstrated prominent TERRA peaks. The intronic regions and 3' end of Mid1 contained some of the strongest PAR-TERRA peaks in the genome. The gene body of Asmt was also a strong binding site. By far the strongest peaks were found in Erdr 1, which itself contains two short stretches of (TTAGGG)n repeats. [Note: It should be emphasized that these TERRA reads could be unambiguously assigned to the Erdr1 repeats--and not telomeric repeats--because pair-end sequencing enabled utilizing the unique sequence at one end to align the other repetitive end.] These results demonstrated that PAR-TERRA not only localizes in cis to the telomeres of sex chromosomes, but also spreads locally in cis to emcompass genes of the pseudoautosomal region.
[0226] Intriguingly, PAR-TERRA also targeted sites in trans. Magnified views showed strong PAR-TERRA binding peaks in the sub-telomeric regions of Chr 2, 9, 13, and 18 (FIG. 3C), and more moderate binding peaks in the sub-telomeric regions of Chr 8 and 19 (FIG. 10). Additionally, PAR-TERRA targeted internal regions of autosomes. Many binding peaks occurred within genes, especially within introns, as exemplified by Abcb10, Uchl1os, and Hes3 (FIG. 3D). PAR-TERRA also targeted internal (TTAGGG)n telomeric repeats which occur at a number of locations throughout the genome (one example shown in FIG. 3C; NOTE: The reads could be assigned unambiguously to the internal repeats because of pair-end sequencing, in which the unique end is used to align the repeat end). We conclude that TERRA and PAR-TERRA transcripts are not confined to telomeric ends of mouse chromosomes.
Example 4. Epigenomic Regulation by PAR-TERRA
[0227] Because PAR-TERRA accounts for the vast majority of TERRA transcripts in the nucleus and has both X-linked and autosomal targets, we examined its effect on gene expression on a genome-wide basis. We perturbed PAR-TERRA expression using knockdown (KD) approaches to avoid undesirable consequences of genetically deleting telomeres. Neither siRNA nor shRNA resulted in knockdown. On the other hand, single-stranded antisense oligonucleotide (ASO) locked nucleic acids (LNA) gapmers led to substantial depletion of TERRA after 12 hours in ES cells, as shown by Northern blot analysis (FIG. 4A, 11A) and RNA FISH (FIG. 4B, 11B). ASO's to TERRA sequences and PAR-specific sequences (31 k) achieved similar results. At optimal LNA concentrations, at least 75-90% of PAR-TERRA were degraded as quantitated by Northern analysis (FIG. 4A, 11A). RNA FISH showed a substantial depletion of both TERRA and PAR signals in >86% of nuclei (n=217) after 6 hours (4B, 11B). Notably, treating with 31 k-PAR gapmers dramatically reduced TERRA RNA FISH signals (FIG. 4B). Conversely, administering TERRA gapmers also reduced PAR FISH signals. These data provide strong support for the idea of a continuous PAR-TERRA transcript and the conclusion that PAR-TERRA accounts for the majority (.about.90%) of telomeric transcripts in ES cells.
[0228] We then carried out transcriptomic analysis on two biological replicates of ES cells after 12 hours of PAR-TERRA depletion (FIG. 4, 11C). Analysis of the biological replicates of TERRA-specific and PAR-specific KD's revealed overlapping transcriptomic changes (FIG. 4C). Analysis using Cuffdiff2 uncovered 126 differentially expressed genes after TERRA KD and 324 after PAR KD in ES cells, among which 56 genes were shared between the TERRA- and PAR-specific KD cells. In MEFs, TERRA KD led to 137 significant changes and PAR KD led to 309, among which 36 genes were shared. Among the shared genes for each cell type, the changes in gene expression after PAR and TERRA KD were very similar (FIG. 4D). Among 8 genes that were shared between female ES cells and MEFs, the expression changes were also highly similar (FIG. 4E).
[0229] On the other hand, there was a significantly increased probability that genes with PAR-TERRA binding sites would be downregulated by PAR-specific KD (FIG. 4F). The probability density function for 565 genes with PAR-TERRA binding sites was significantly different from that for the 14,724 genes without a PAR-TERRA site (FIG. 4F; KS test, P<0.0001). PAR KD resulted in net downregulation of genes with PAR-TERRA binding sites (left-shift of red distribution). Among all downregulated genes after PAR KD, the degree of downregulation was significantly more pronounced for those with PAR-TERRA sites (FIG. 4G, right panels; .chi..sup.2 test, P<0.001), possibly indicative of a direct effect on PAR-TERRA target genes. In contrast, among the upregulated genes, there was no signifcant difference between genes with and without a PAR-TERRA site (.quadrature..sup.2 test, P=0.26), suggesting that upregulation may be an indirect consequence. These data argue that PAR-TERRA RNA exerts a direct positive effect on target genes.
[0230] The non-overlapping transcriptomic changes for TERRA- versus PAR-specific knockdowns may suggest the presence of a gene class targeted by TERRA-intrinsic transcripts (containing only UUAGGG repeats), rather than by PAR-TERRA. Consistent with this, we observed a number of autosomal genes--particularly those within sub-telomeric regions--where TERRA RNA was the predominant bound form (FIG. 5A). At such genes, TERRA KD consistently resulted in gene downregulation, as shown by RNA-seq and confirmed by RT-qPCR (FIG. 5B). Such autosomal sub-telomeric genes might therefore be controlled by TERRA transcripts produced in cis, perhaps in addition to some contribution from X-linked PAR-TERRA in trans. We proposed that genes responsible for facioscapulohumeral muscular dystrophy (FSHD) can be controlled in this way. The FSHD locus is located in the subtelomeric region of human Chr4 and contains coding genes FRG1, FRG2, DUX4, and the macrosatellite repeat, D4Z4. FSHD is caused by ectopic expression of these genes when the D4Z4 repeat contracts and becomes "activated". Thus, PAR-TERRA or Chr4-specific TERRA could be targeted to downregulate the associated subtelomeric genes.
Example 5. PAR-TERRA Protects Pseudoautosomal Genes and Escapees from XCI
[0231] ChrX has a large number of PAR-TERRA sites (FIG. 3A). In d0 ES cells,
[0232] ChrX harbors 84-86 PAR-TERRA sites; in MEFs, ChrX harbors 30-94 sites, with one broad domain at the distal end of ChrX, another around the X-inactivation center, and several additional hotspots in more proximal regions of ChrX (FIG. 5C,D). Intriguingly, PAR-TERRA densities were greater at escapees than at genes subject to XCI (FIG. 5E; P<0.05). Escapees play important roles in human disease (e.g., XO Turner Syndrome) and generally have ChrY homologues that render XCI unnecessary for these genes (Berletch et al., 2010; Berletch et al., 2011; Deng et al., 2014). Escapee genes are located throughout ChrX, and may occur singly or in clusters (Berletch et al., 2011; Lopes et al., 2011). In humans, 15% of X-linked genes escape silencing, whereas approximately a dozen or so genes escape XCI in mice (Carrel and Willard, 2005; Yang et al., 2010). Their association with PAR-TERRA raised the possibility that PAR-TERRA could regulate escape from XCI.
[0233] To test this idea, we performed quantitative RT-PCR. Significantly, PAR-TERRA KD resulted in downregulation of all pseudoautosomal genes, including Mid1, Erdr 1, and Asmt (FIG. 5F). This downregulation was confirmed by RNA-seq analysis and was similar to the downregulation at sub-telomeric regions of autosomes after TERRA KD (FIG. 5A,B). Thus, one of TERRA's cis functions may be to protect sub-telomeric genes from position effects of telomeric heterochromatin. To examine Xi-specific changes, we performed allele-specific RNA-seq analysis using a hybrid MEF clonal cell line in which the Xi is always of Mus musculus origin and the Xa is of Mus castaneus origin (Pinter et al., 2012). RNA-seq analysis confirmed downregulation of PAR genes and additional known escapees outside of the PAR, such as Shroom4, Kdm6a, 1810030O07Rik, as well as escapees (Fgf13, Mbtps 2, Huwe1, Sept6, Aifm1, and Kif4) observed in our cell line. We concluded that PAR-TERRA promotes expression of escapee genes on the Xi.
[0234] We next investigated the mechanistic relationship between PAR-TERRA and escapees. While escapee gene bodies generally have low Xist coverage, their flanking regions are often marked by high Xist coverage suggestive of a boundary that sequesters Xist and prevents it from entering escapee loci (FIG. 6A, Mid1 shown)(Simon et al., 2013). Intriguingly, metagene analysis revealed that PAR-TERRA was highly enriched at the transcriptional start sites (TSS) of escapee genes, where the Xist boundary occurred (FIG. 6B). For example, Mid1 was marked by a sharp border of Xist RNA beyond which Xist coverage dropped off dramatically (FIG. 6A). To determine how PAR-TERRA affected Xist spreading near escapees, we carried out CHART-seq of Xist following knockdown of PAR-TERRA for 6 hours. Scatterplot analysis of Xist coverages in 40-kb windows showed that Xist binding changed very little for nearly all Xi loci (FIG. 6C, Pearson's r>0.90), with the notable exception of outliers corresponding to some escapees (FIG. 6C, red dots). Upon PAR-TERRA KD, we observed decreased accumulation of Xist at the TSS and a shift to flanking regions (FIG. 6D). Taken together, these data suggest that PAR-TERRA protects escapees from silencing by sequestering Xist at the TSS of escapees, thereby preventing the spread of Xist into upstream regulatory regions and into the TSS regions of escapees.
[0235] Given that .about.90% of PAR-TERRA foci occurred next to but did not overlap the Xist cloud (FIG. 6E; 8D)(Zhang et al., 2009), we considered the possibility that PAR-TERRA might organize a privileged, transcription-permissive compartment next to the Xi. We noted that PAR has a higher colocalization rate with other escapees, such as Ftx and Jpx, than with genes subject to XCI, such as Hprt (FIG. 6F; P<0.0001). Depleting PAR-TERRA resulted in a statistically significant decrease in colocalization frequency (FIG. 6G; P<0.02, 0.001). These data are consistent with the idea of a privileged compartment that is geographically close to the pseudoautosomal region.
[0236] Gene ontology (GO) analysis was performed, restricted to differentially expressed genes in TERRA KD (P adjusted value <0.05 in DEseq2 analysis). The top 10 enriched biological process terms are listed in Table 2, in the unregulated gene set or in downregulated gene set in MEFs.
TABLE-US-00010 TABLE 2 Category Term Count PValue Benjamini MEF up-regulated GOTERM_BP_FAT GO: 0007155~cell adhesion 25 9.26E-06 0.011919699 GOTERM_BP_FAT GO: 0022610~biological adhesion 25 9.54E-06 0.006157583 GOTERM_BP_FAT GO: 0030029~actin-filament-based process 12 1.12E-04 0.047233272 GOTERM_BP_FAT GO: 0034330~cell junction organization 6 1.35E-04 0.042637379 GOTERM_BP_FAT GO: 0030036~actin-cytoskeleton organization 11 2.94E-04 0.073349276 GOTERM_BP_FAT GO: 0034329~cell junction assembly 5 2.95E-04 0.061751534 GOTERM_BP_FAT GO: 0010810~regulation of cell-substrate adhesion 6 3.97E-04 0.070796403 GOTERM_BP_FAT GO: 0034621~cellular macromolecular complex subunit organization 13 5.34E-04 0.082874247 GOTERM_BP_FAT GO: 0001944~vasculature development 13 6.40E-04 0.087939941 GOTERM_BP_FAT GO: 0034622-cellular macromolecular complex assembly 12 6.75E-04 0.083770541 MEF down-regulated GOTERM_BP_FAT GO: 0007049~cell cycle 27 2.17E-08 2.99E-05 GOTERM_BP_FAT GO: 0051726~regulation of cell cycle 14 2.06E-06 0.001425534 GOTERM_BP_FAT GO: 0007346~regulation of mitotic cell cycle 10 2.42E-06 0.00111682 GOTERM_BP_FAT GO: 0008219-cell death 21 3.42E-06 0.001182773 GOTERM_BP_FAT GO: 0012501~programmed cell death 20 4.72E-06 0.001304329 GOTERM_BP_FAT GO: 0016265~death 21 4.86E-06 0.001120723 GOTERM_BP_FAT GO: 0006915-apoptosis 19 1.41E-05 0.002783669 GOTERM_BP_FAT GO: 0051130~positive regulation of cellullar component organization 10 1.74E-05 0.00300798 GOTERM_BP_FAT GO: 0033043~regulation of organelle organization 11 1.81E-05 0.002783466 GOTERM_BP_FAT GO: 0022402~cell cycle process 17 2.36E-05 3.00325865
Example 6. TERRA Facilitates Homologous Sex Chromosome Pairing
[0237] In mammals, pairing between two homologous chromosomes rarely occurs outside of meiosis. An exception is the X-chromosome, which undergoes transient homologous interactions prior to the initiation of XCI in ES cells (Bacher et al., 2006; Xu et al., 2006). Their transient pairing via the noncoding Tsix and Xite loci is proposed to result in mutually exclusive selection of Xa and Xi and, thereby, to ensure upregulation of Xist RNA from a single ChrX (Xu et al., 2006). To date, only a few to regulatory factors have been identified, including a 15-kb "pairing center" from which the noncoding Tsix and Xite RNAs are produced (Xu et al., 2007). Tsix and Xite RNAs work together with the chromosomal architectural protein, CTCF, to establish the paired state (Kung et al., 2015). How the two X-chromosomes search and identify each other during the pairing process is not known.
[0238] Interestingly, PAR-TERRA ChIRT revealed strong PAR-TERRA binding sites in Xite and Tsix (FIG. 7A). These peaks grabbed our attention because they occurred within the pairing center and were specific to ES cells. To test a role in pairing, we knocked down TERRA and measured interchromosomal distances in a 3D DNA FISH assay (Xu et al., 2006; Kung et al., 2015). We measured inter-allelic distances at the telomere, the X-inactivation center (Xic), and a distant locus, Hprt. Using Xic probes mapping to Tsix/Xist, we observed a left shift in the cumulative frequency curve between days 0 and 4 of differentiation, indicating an increase in the number of nuclei displaying inter-allelic distances of <0.1 nuclear diameters (ND) or <1 micron (FIG. 7B, 13A), a distance implying the occurrence of pairing, as previously determined (Bacher et al., 2006; Xu et al., 2006). By contrast, the number of such events increased minimally between Hprt alleles. Curiously, however, when measured between the telomeres (TeloX) or between PAR, there was also a significant increase in allelic colocalization events. The degree of left shift indicated a very robust telomeric pairing (FIG. 7B). Telomeric pairing was X-specific and was not observed between homologous autosomal telomeres (FIG. 7C, Chr2 telomere shown). Moreover, the time window of telomeric pairing overlapped with that for Xic-Xic pairing.
[0239] This unexpected relationship raised the possibility that the X-telomeres may be involved in somatic X-X pairing. Since the 19203 s, the telomere has been suspected to facilitate homology searching during meiotic chromosome pairing, where a single telomeric "bouquet" (a clustering of telomeric ends of all chromosomes) nucleates synapsis and enables synaptic extension along the length of homologous pairs (Maguire, 1984; Rockmill and Roeder, 1998; Reig-Viader et al., 2013; Xiang et al., 2014). During male meiosis, Chr X and Y also pair in spite of their limited homology, and they do so via their pseudoautosomal region--the only region of homology between the two sex chromosomes.
[0240] We explored the possibility that telomeric clustering could also mediate sex chromosome pairing in non-meiotic cells. First, given the occurrence of meiotic X-Y pairing, we asked whether somatic telomeric pairing extends to the X and the Y. Indeed, during differentiation, the inter-PAR and inter-telomeric distances between Chr X and Y shifted to the left, much in the same way as those observed for X-X telomeric pairing (FIG. 7D, 13B). This colocalization of telomeres/PARs was also transient, occurring on day 4, but not on day 0 or 12. Serial RNA/DNA FISH showed that, while the paired telomeric signals of the sex chromosomes were very close (<1.mu.m between two dots) or overlapped (one dot), the rest of the two chromosomes were not paired, as visualized by Chr X and Y painting probes (FIG. 7E). These data demonstrate that somatic telomeric pairing is not limited to the two female X-chromosomes. Transient homologous chromosome pairing also occurs between Chr X and Y during differentiation of male ES cells.
[0241] We asked whether X-X and X-Y pairing might be controlled by PAR-TERRA in cis. To examine telomeric pairing, we assessed pairing frequencies between telomeres on d4 after treating cells with LNA gapmers to degrade TERRA RNA. Significantly, we observed a right shift of inter-telomeric (PAR-PAR) distances in TERRA KD cells relative to control cells that were administered a scrambled (Scr) LNA. These results demonstrated a loss of telomeric colocalization when TERRA RNA was depleted (FIG. 7F). Telomeric X-X pairing in female cells and X-Y pairing in male cells were both affected. Therefore, TERRA RNA is required for somatic telomeric pairing of sex chromosomes. Given the presence of PAR-TERRA binding sites at the pairing center, we investigated whether Xic-Xic pairing in female cells might also be affected by the loss of TERRA. We treated differentiating female ES cells with TERRA LNAs and measured inter Xic distances at day 4. Relative to cells treated with the control Scr LNA, there was a significant right shift of colocalization frequencies between the Xic alleles after TERRA KD (FIG. 7G), indicating a loss of pairing. Thus, both types of trans-interactions--telomeric pairing and Xic Xic pairing--require the function of TERRA.
[0242] These data lead to the notion that PAR-TERRA RNA could facilitate homologous interchromosomal interactions by inducing co-clustering of crucial pairing sites. Because the pairing center (FIG. 7A) and the pseudoautosomal region (FIG. 2H) are both major hotspots of PAR-TERRA binding, we examined the possibility that intra-chromosomal cis-interactions between the Xic and telomere could bring the Xic to the juxta-telomeric compartment, which in turn would bring the two Xic's in close proximity due to the action of telomeric pairing. Indeed, DNA FISH using Xic and sub-telomeric (PAR) probes showed that the Xic and telomere frequently colocalized on day 4 (FIG. 7H). This co-clustering depended on TERRA RNA, as knocking down TERRA abolished the Xic-telomeric interactions (FIG. 7H). We conclude that both (i) cis-interactions between the Xic and the telomere and (ii) trans-interactions between two telomeres require TERRA RNA. We propose that TERRA RNA tethers the ends of sex chromosomes to facilitate inter-chromosomal interactions between the Xic's (FIG. 71).
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OTHER EMBODIMENTS
[0304] It is to be understood that while the invention has been described in conjunction with the detailed description thereof, the foregoing description is intended to illustrate and not limit the scope of the invention, which is defined by the scope of the appended claims. Other aspects, advantages, and modifications are within the scope of the following claims.
Sequence CWU
1
1
611151450DNAHomo sapiens 1gctcaatgca acctccacct cccgggttca cgccattctc
ctgcctcagc ctcctgagta 60gctggcacta caggtgccca tcacgcaccc aggtagtttt
tgtgttttta atagagacgg 120ggtttcacca tgttggtcag gctggtctcg aactcctgac
ctcatgttcc acccgccttc 180gcctcccaaa gtgctgggat gacaggcgtg agtcactgca
cactcggctg tttttttttc 240ttttgagatg gagtctcggt ctatcattca gactggagtg
cagtggcacg atgtcagctc 300aatgcaacct ccatctcccg gcttcaagca gttctcctgc
ctgagcctcc cgagtaactg 360ggactacagg cgcctgccac acacccagct aagttttgta
tttttagtag agatgggatt 420tcaccatgtt ggtcaggctg ctctcaagct cctgacctca
tgatccaccc acctcggcct 480cccaaagtgc tgggaagaca ggcgaagtca ccacgcccag
ccaccccatc tctattttaa 540agaaaatgaa aacgtattat catcggtcct atgatcacca
acatttggcc caaacaaagt 600cacaatactt ggaaattcgg gggtgaaact gcagccgccg
cgtcccgaac ttcagaaggg 660tcccgtcagc accacagcag cttctgattg agcgcgatga
cgtcactgac gaagccgtct 720gcgccgatga agtcccccgc gatgatgttg gtgcaccgtg
aacccggccc cgggcactgc 780tctcggaccc acgcgctcag ccgcggaagg ttgggcagcg
tcatcttctc cagggactcg 840gacgggtgcg ccagaacgta ctgcaggttc tccgtgaggt
tgatgccggc cacgaacaac 900cctcctgcaa cggtgagggt ggggagaggt tacacggtca
cgggcctcac ccgcctgttt 960ctccctccta gtcacattat tagaggttcg catctcagga
attaagagtt gaaagcacca 1020tgtccaacaa ggaaattggg tgagctttgc ttataaagcg
tggtgggcag tagacaaccc 1080caaagatgct cacgtcgtaa caccgtgtgg gagacagaat
aatgtcccca aagatgtcca 1140catcctaatc cccatgtgat agacagaata atggccccaa
agatgtccac gtcctaatcc 1200ccatgtgata gacagaataa tgtccccaaa gatgtccacg
tcctaatccc catgtgatag 1260acaggataat ggccccaaag atgtccacgt cctgatcccc
atgtgataga cagaataatg 1320tccccaaaga tgtccacgtc ctaatcccca tgtgggagac
agaataatgt ccccaaagat 1380gtccacgtcg taatccccat gtgatagaca gaataatggc
cccaaagatg tccacgtcct 1440aatccccatg tgatagacag aataatgtcc ccaaagatgt
ccacgtccta atccccatgt 1500gggagacaga ataatgtccc caaagatgtc cacgtcctaa
tccccatgtg atagacagaa 1560taatgtcccc aaagatgtcc acgtcctaat ccccatgtga
tagacagaat aatgtcccca 1620aagatgtcca cgtcctaatc cccatgtgat agacagaata
atggccccaa agatgtccac 1680gtcctaatcc ccatgtggga gacagaataa tgtccccaaa
gatgtccacg tcctaatccc 1740catgtgatag acagaataat gtccccaaag atgtccacgt
cctaatcccc atgtgggaga 1800cagaataatg tccccaaaga tgtccacgtc ctaatcccca
tgtgatagac agaataatgt 1860ccccaaagat gtccacgtcc taatccccat gtgatagaca
gaataatgtc cccaaagatg 1920tccacgtcct aatccccatg tgatagacag aataatgtcc
ccaaagatgt ccacgtccta 1980atccccatgt gggagacaga ataatgtccc caaagatgtc
cacgtcctaa tccccatgtg 2040atagacagaa taatgtcccc aaagatgtcc acgtcctaat
ccccatgtga tagacagaat 2100aatgtcccca aagatgtcca cgtcctaatc cccatgtgat
agacagaata atgtccccaa 2160agatgtccac gtcctaatcc ccatgtgata gacagaataa
tggccccaaa gatgtccacg 2220tcctaatccc catgtgatag acagaataac agccccaaag
atgtccacgt cctaatcccc 2280atgtgggaga cagaataatg tccccaaaga tgtccacgtc
ctaatcccca tgtgatagac 2340agaataatgt ccccaaagat gtccacgtcc taatccccat
gtgggagaca gaataacagc 2400cccaaagatg tccacgtcct aatccccatg tgatagacag
aataatgtcc ccaaagatgt 2460ccacgtccta atccccatgt gggagacaga ataacagccc
caaagatgtc cacgtcctaa 2520tccccatgtg ggagacagaa taatgtcccc aaagatgtcc
acgtcctaat ccccatgtgg 2580gagacagaat aatggcccca aagatgtcca cgtcctaatc
cccatgtggg agacagaata 2640atggccccaa agatgtccac gtcctaatcc ccatgtgata
gacaggataa tgtccccaaa 2700gatgtccacg tcctgatccc catgtgatag acagaataat
gtccccaaag atgtccacgt 2760cctaatcccc atgtgataga cagaataatg tccccaaaga
tgtccacgtc ctaatcccca 2820tgtgatagac agaataatgg ccccaaagat gtccacgtcc
taatccccat gtgatagaca 2880gaataatgtc cccaaagatg tccacgtcct gatccccatg
tgggagacag aataatgtcc 2940ccaaagatgt ccacgtccta atccccatgt gatagacagg
ataatgtccc caaagatgtc 3000cacgtcctaa tccccatgtg atagacagaa taatgtcccc
aaagatgtcc acgtcctaat 3060ccccatgtga tagacagaat aatggcccca aagatgtcca
cgtcctaatc cccatgtggg 3120agacagaata atgtccccaa agatgtccac gtcctaatcc
ccatgaggta gacaggataa 3180tggccccaaa gatgtccacg tcctaatccc atgtgggaga
cagaataata tggccccaaa 3240cttgtccaca ttcttatccc ccatgtgata gacaggaaga
atgctgttgt cttgggcact 3300aagtctgtgc catctcttat gaggcttata gagagggttg
acgttgacca gtgattctca 3360aagtggggtc cctgcaatag ttagaaatgc aaatttgggg
gctccaccta catctgctga 3420gccggaatct cctgcaagcc atatttgaag aagctccccc
agaggtaggt tccagtgccc 3480ctgtgttgac cagctggact gattccacag ccagagacgg
caaaggcaac agacgtttat 3540ggccaagttc tctcagtggt ttttaacacg tatttctagg
ctgggcacgg tggctcatgc 3600ctgtcatccc agcacgttga gaggttgagg ccggtggatc
atgaggtcag gagttcaaga 3660ccagcctgac caacacgctg aaaccctttc tctagtaaaa
acacatccaa aaattagctc 3720agcatggtgg tacgtgcccg taatcccagc tactcgggag
gctgaggcag gagaatcact 3780tgaatccagg aggtggaggt tgcagtgagc cgagatcacg
ccattgcact ccagcctggg 3840tgacagagca agactctgtc tcaaaaacaa aacaaaacaa
acaaaaaaag gccgggcaca 3900gtggctcaag cctgtaatcc caccactttg ggaggccaag
gcgggcagat cacctgaggt 3960cgggagttcg agaccagcct gatcaacatg gagaaacccc
atctctacta aaaataaaaa 4020ttagccgggc gtggtgggag gctgaggcgg gagaattgct
cgaacccagg aggcgaaggc 4080tgcagtgagc caagattgcg ccattgcact ctagcctggg
caacaagagc aaaactctgt 4140ctcaaaaaac aaacacacaa acaaaaaaat tttccgcctg
gcaccgtggc tcacgcctgt 4200catcccagca ctttgggaga ctgagacggg cagatcatga
ggtcaggagt tcgagaccag 4260cccgaccaac atggtgaaac cctgtctcta ctaaaaatac
aaaaaaaaat tagccgggtg 4320tggtggcggg cgcctgtagt cccagctact caggaggctg
aggcaggaga atggcttgaa 4380cccgggagac ggaggttgca gtgagccgag atcgcgccac
tgcactccga ccggggcaac 4440aagagtgaga ctccacctca aaaaaaaaaa aaagacattt
ctgaagtctc taaacctcgt 4500tcctgtgtga gggcaagaga ccaagttgaa aaaacctgct
cctttgcccg gcccgtgact 4560gggtttcatg ctgcccctgt gggaagcagc cctcgcggcc
gtgaagatca ccttgagaga 4620acccagccgc aggctgcagg accgagacgg ccccacctgc
caccgtcccc gcggggagga 4680ccttcctccc tccctccctc aggctcctgc ctccggagga
cacggggccg tggctgccga 4740cgctgtctgc acctcacacc ccgtcggtgg cttttttaca
aaaattgtgg tgaaattcac 4800gtacaaaaaa gttacctttt tttttttttc ccaagatgga
gtctcgctct gttgcccagg 4860ctggagtgct gtggcgcgat ttcggctcac ggcagcctcc
gcccccgggt tcaagcaatt 4920ctcctgcctc agcctcccga ggagctggga ttacaggtgc
acacaaccac gcccagctaa 4980atctttttgt atttttacta gagatggggt ttcaccagac
tggtcgcaaa ctcctgatct 5040caattaatcc acctgcctcg gcctcccaaa gtggtgggat
tacaggcgtg agccactgca 5100ccgaaattca cgattttaaa ttgcacaact cggctgggaa
tggtggttca agcagatcgc 5160ttgaccccag aagtttgatt ttgtcttgtt ttgttttgag
acagagtctc gctctgttgc 5220ccaggctgga gtacactggc tcgatctcgg cccactgcaa
cctccgcctt cctggttcaa 5280gtgattcccc tgcctcagcc tcctgagtag ctgggattat
aggcgcgcat caccatgcct 5340ggctaatttt tctctttttt gttttgtttt gagatggagt
cttgctcctg tcgcccaggc 5400tggagtgcag tggcgcgacc atggatcaca gcaacctccg
cctcctggat tcaagcattt 5460ctcctgcctc agcctcccaa gtagatggga ttacaggtgc
ctattttttt tttttttttg 5520agacagagtt ccactctgtc gcccaggctg gagttcagtg
gcgtgatctc ggctcactgc 5580aagctccgcc tcccgagttc acaccattct cctacctcag
cctccggagt agctgggatt 5640acaggcgccc gccaccacgc ccggctaatt ttttgtattt
ttagtagaga cggggtttct 5700ccatgttagc cgggatggtc tcgatctcct gacctcatga
tccgcccgcc tcggcctccc 5760gaagtgctgg gattacaggc gtgagccacc gcgcccggcc
tgtgcccgct aatttttgta 5820tttttgctag agaagaggtt tcgccatgtt ggccaggctg
gtctccaaac tcctgacctc 5880aggtgatcca cccaccttgg cctcccaaag tgctgtgatc
acaggtgtga gccaccgcac 5940ctggctgaca ccaggagttt gagaccagcc tggccaacac
agtgagaccc cttctctaat 6000caaagaatta actaaaaaaa ataaagtgga ttcacgttgt
gcaactccga cctctcccta 6060gttccagaac attctcatcg tcctaaaagg agagaccctg
tttccatgaa gcagtcagtc 6120ctcatttccc ctccgcagcc cccggcaacc acaaatcctc
tttctgtctc tggattggca 6180tgttctgggc atttcctgta aatggattca cacactacgt
gtccttttgt gtctggcttc 6240tctcactgag cgtgatgtct taaggtttgt gcccgctgca
tccttgtcag agcctcgttc 6300tttttcatgg ctgtgtaata ttccaccgcg tggatggacc
acaccttgtt gatccctccc 6360cccgccaatg tacatggact gctttctccc tgggtgcttc
ttaagtagag acagggtttc 6420atcacattgg tcaggccggt ctcgaactcc cgacctcagg
tgatctgccc gcctcagcct 6480cccaaagtgc taggatgaca ggcatgaacc actgcgcccg
gccgctaagt tttatttcta 6540gtaaagttgg ggtctcacta tgttggccag gctggtctca
aactcccgac ctcaggtgat 6600ccacccgcct cggcctcccg aagtgctggg attacaggta
cagggattac cacgcccagc 6660tcatggattc cttttaaatt gttttcacgt aaaagtgaag
gcaagtccat gtggacccgg 6720cctgccgcag ggcgtcacgg gaggctgtgt ggaatctacc
cccacgaggg gcgacctggt 6780acctgggcgg ccgcagctct tcatggtctc caggtatcgg
atgagggcct cggtcttcac 6840cctgtttccc caccagtagg ggactcctgg ccacagctcg
tggtgccggc gcaaggagct 6900ctcgtcttca taggagacga tgacctgttg gccccgggac
cacagctgcc gcagtgtcgg 6960cacctcctgc aaaggaccag agttaagggg tgcaggggag
agaggagagc cgggggcacc 7020tgggagagcg gagggctggg aagtcgggac accggcccaa
cacgagtata aaccaaaaat 7080gaaattctgg ccgggcgcag tggctgacgc ctgtaatccc
agcactttgg gaggccgagg 7140tgggtggatc acctgaggtc aggagtttga gaccagcccg
ggcaacatgg tgaaacccca 7200tctctactaa aaatacaaaa attggccggg tgcggtggtg
cacgcctgtc atcccggcta 7260gtcagaaggc tgaggtagga gaatcgtttg aacctgggag
gcagaggttg cggtgagccg 7320aggtttcgct attgcactcc agcctgggag acagaccgag
actccctctc aaataaataa 7380ataaattaag tatggccagg tgcaggggct catgcctgta
atcccagcac tttgggagga 7440cacggcggga ggatcactcg aggccaggaa ttcgagcctg
ggctgcacag ggtgaccctg 7500tctctatttt tatatattta tttattttta ttttttattt
tttgagacgg atctcgctct 7560gtctcccagg ctggaatgca gtggcgcgat ctcggctcac
tgcaacctcc accccccggg 7620ttcacaccat tctcctgcct cagcctcccg agtagctggg
actacaggcg cccgccacca 7680cgcccggcta attgtttgta ttttgtgtta gtagagacgg
ggtttcaccg tgttagccag 7740gatggtctcg atgtcctgac ctcatgatcc gcccgcctcg
gcctcccaaa gtcctgggat 7800gacaggtgtg agccactgcg tccggcacac ccaccgccac
acccagataa ttttggtatt 7860tttagtagag acggggtttc accatgttgg ccaggatagt
ctcaatctct tgacctcgtg 7920atccgcccgc ctcggcctcc caaagtcctg ggatgacaag
cgtgagccac cacacccagc 7980ctaattgttg tatttttagt agacaccagg tttcaccatg
ttggccagga tagtctcgat 8040ctcttgacct cgtgatccac ccgcctcggc ctcccaaagt
gctgggatga caggcgtgag 8100ccaccgcgcc cggctgacgc tgcacacatt tctaaacccg
tcaagggaag cagatctcac 8160caggagccac cccaccgggt cagccagggc cccccacact
gcgggagagc aggcagcccc 8220cgttcgacgg cttcacctgc tacaggaatc atggcagcac
ccacacccag ggcacagcaa 8280atggagtctg aggctgacga tgcccctgcc ccgggagaga
cgtgcggata tccttcccct 8340cctcacccca cgaggacaca gcatgtcccc gaagatgttc
ttgatacagg cgaccaggta 8400ctcgtgcagg tcctcgctca gcccctcgaa gtttctgcag
gccaggatga ccacctcgcg 8460tggatgccgc tccagccact ccgagatttc cgtgagtgtg
tcctggggag gggggtgctg 8520ggctgagtcc tgcacgactc caacaccaca gggaaggcgg
ggtgtggcgg ctcacgcctg 8580tcatcccagc aatttgggag gccgaggcgg gtggatcacc
tgaggttagg agtttgagac 8640cagcctagcc aacatggtga aaccccgtat ctactaaaaa
tacaaaaatt agctgggcgt 8700ggtgtccggc gtctgtaatc ccagctactt ggaaggctga
ggcaggagaa ttgcctgaac 8760ccaggaggca gaggttgcag tgagctgaga ttgcaccact
gcactccagc ctgggcgaca 8820cagcaagact ccatctccaa aaaaaaaaag caaaaaaaaa
agaaatctcc gtaacggatt 8880ggcggggtca gtgtctcctg tctggtgtat aggtgacgtc
acccttccat taaagaccgg 8940gcgtttcctg tccacatctg catgtggctg tttcatcccc
acgggagctt ggccacctcc 9000cgccgtcccc cttgcttccc acctcagccc ggccgcacct
gcaccagcgc ccggccgcct 9060cccgctgtcc cccttgcttc ccacctcagc ccggccgcac
ctgcaccagt gcccggccgc 9120ctcccgctgt cccccttgct tcccacctca gcccggccgc
acctgcacca gtgcccggcc 9180gcctcccact ctccccattg cgtcccacct cagcccggcc
gcacctccac cagcgccgtt 9240gtgtacacca tatggacaaa gtgcaggttc ttctccgagc
cctccagcat gtgggctatc 9300cgcaggtcca ggtaccgcac cccggcatcc agctgctctg
tgacgtccag tgcctgtgga 9360cagaggctgc tgtcatgtct gcctggctga gcgccgcgtc
tggggggctc aggaatgggc 9420tgtggggttg gcccacccgc atgtcctgct gcccactggg
acgtggatgt cgtaacaaca 9480gctgtttgta tgtgctggga gcgctgcagc cacggggacc
tgcatttgga aaacctcatc 9540tccggggacc tggccttttt tttttttttt tgagacggag
tctcgctctg tcacccaggc 9600tggagtgcag tggtgcaatc tgggctcact gcaagctccg
cctcccgggt tcatgccgtt 9660ctcctgcctc agcctcccca gtagctggga ctgcaggcgc
ccgccaccgc gcccagctaa 9720ttttgttttg tatttttagt agagatgtgg tttcaacatg
ttagccagga cggtctcgat 9780ctcctgacct cgtgatccac ccaccttggc ctcccaaagt
gctgggatta caggcgtgag 9840ccaccgcgcc cggcctctac taaaaatttt aaaaatcagc
ctgggtgtgg tggtgtacac 9900ctgtagtccc agctgcccgg gaggctgagg aaggaggatc
ctttgatcct gggaggccca 9960ggctgcagga agctgagatc gcaccaccgc actccagtct
gggtgagaga gcgagactcc 10020atctctaaag gaatgaatga atgtgattat tagggagaaa
ggggcctgtc tccctgtttc 10080ccagggacta gcagatgcct gactgcaaac tgcagacccg
cctcaggtcc taaagacacg 10140agaaatgagt ccttgtctgt cttgagtgca ggcatgaaag
gggttgtctc ggccgggcgc 10200ggtggctgac gcctgtaatc ccagcacttt gggaggctga
ggcgggtgga tcacgaggtc 10260aggagttcga gaccatcctg gctaacacag tgaaaccctg
actctactca aaataccaaa 10320aattagccgg gcgtggtcgc gggagcctgt agtcccagct
actcaggagg ctgagacagg 10380agaatggcgt gaacccggga ggcggagctt gcagtgagcc
gagatggcac caactgcact 10440ccagcctggg cggcagtgag actccgtctc aaaaaaaaaa
aaaagaaaaa gaaagaaaaa 10500gaaaggtgtt gtctctgctg ggatgcaaca gggcgagacc
ctctccctct gcagctctca 10560gtggaggcct gcgatgctca cggcattagc tttacgccat
ttaataaaat gctgggccgg 10620gcgcggtggc tcacgcctgt aatcccagca ctttcggagg
ctggggcggg cagatcatga 10680ggtcaggaga tcaagaccat cctgactaac acggtaaaac
cccatctcta ctaaaaatac 10740aaaaaattag ccaggtgtgg tgacaggtgc ctgtagaccc
aggtacttag gaggatgagg 10800caggagaatc gcttgaaccc aggcagcgga ggttgcagtg
agccgagatc acgccactgc 10860actccagccc gggtaagaag agtgagaccc tgtctcaaaa
aataaataaa taaaaacact 10920gttcccctct cttccacctc tggggagggg ttctgggtgg
gcagcaggtt ttgttttaat 10980cctgtctccg cagctgggat aggaacctgc ctcctgagcc
cacagggcac cactcaaacc 11040ctacctgggt gaggggccat ttcagcacca cggggccgtg
ggccccacat agctgacagg 11100ccaggtcagc agcacggggc acagaccgta cctgggtgac
ggaccatttc agcacgacag 11160ggcgcgtgat gcagggcaag gccttgttca gcagctgcag
cagccgggac tcctcgtgcg 11220aaatggggga cttcttgttc aggcagtacg tcatcgtgtc
gtggctccct gagagcaaag 11280cacacacgcg gacatgtcac cacgagtccg tccccgccac
ctgctgtgag tcgctccaca 11340gcccgcctac agcacaggct gctgcccgcc cacagcacag
gcacaggtat ggcgggaggg 11400gtgcacgctg acccccaaaa ctcacgtcca ctggaacctg
ggaacacgac ccgtgttgaa 11460acagggtctc tgcagatatc attaggttga aatgagatca
tcctggagta gggcgggccc 11520ccaaatccag tgacaggtgt ccgtctaaga cacaagagga
ggagacagac acagaggagg 11580aggcctcgtg gagacggagg cagagactgg agtgatgcgg
ccacaagccc agggatgcct 11640ggagccccca ggagctggga gaggcaggaa ggatccccca
ctctagagcc tctagaagga 11700actgaataca atttcaatga cttgagtggt gatccccaaa
agagctgttc aagtcctaac 11760cccctgccca gaacctgtga atgggatcct gtttggaaat
agggtcttta cacatgctct 11820caaaatgctc aagatgaagt catcttggct ttgtgctggg
tcctaaatgc aatgacaggt 11880gtccttagga gacacagacc cagaggagga ggccacgtgg
agatggaggc agagactgga 11940gtgatgcggc cacaagccca gggatgcctg gagcccccag
gagctgggag aggcaggaag 12000gaccctcccc tagagcctca ggaggacgtg tggtcctgcc
catatcttga cttcagattt 12060ctgtatctag aactgggaga gagtaaattt ctgttctttg
ccgcctcctg acgtgtgctc 12120acttgttatg gtaaccgcaa gaaacacaga cctttgtaga
gtttgactga tggctgacgt 12180ttgcatttcc tgcctatgac acgtagttgt tatttcttaa
atatagatat aaatatatct 12240atatttaaga tatatatatt taagatatat atgacatata
tctatatata aacatatata 12300gtatctatat ctataaacaa agatatatag tatctatatc
cataaacata tatagtatct 12360atatctatat ataaacatat atagtatcta tatctatata
taaacatata tagtatctat 12420atctatatat aaacatatat agtatctata tctatatata
aacatatata gtatctatat 12480ctatatataa acatatatag tatctatatc tatatataaa
catatatagt atatattcta 12540tatataaaca tatatagtgt atatatatct atatataaac
atatattagt atatatttac 12600ataaatacat atttttgcat aaatatgtat ttatataaat
atataaaata tatatccaca 12660tattatgttt ataaatataa tatataaatg tacttatgta
tcatatattt atataaatat 12720atgatatata ttttatattt tacatttact tatttatata
ttatatataa atataaatat 12780gtatgtttat atataaatat gtacacttac atataaatgt
gtgtgtgtat atacatattt 12840gcagagatgg ggcctcacta tgttgcccag gctgctctca
aactcctaaa ctcaagtgat 12900cctcctgcct tggcttccca aagtgctggg attacaggcg
tgagccacca cgcccggcct 12960tcccccttta aatcccctga ggaacgtgaa gcccctttac
atcctctgag gaacgtggac 13020cccctttaaa tccccagacc ccgagaggca ttggaacgaa
gccacagtca cctgctcccc 13080cgatcttgag ctaaggtgtt aaggaaggag accagtactt
ctcctgctgc cccctacccc 13140caccttgcct agtttataag acaggagaaa gcaaaaggtt
ggaaagaaac agaagtaaga 13200taaatagcca gacaaccttg gcaccaccac ccagccctgg
gagttaaaat aatatcaatc 13260cataacctaa accacttctg ttatctgtaa atgccagacg
ttgtatgaaa aagcgttaca 13320aaactttctg ttctgttagc tgacacatgt agcccccagt
cacgttcccc acacttgctt 13380gatttatcac gaccccttca cgtggacccc tcagagttgt
aagcctttaa aaaggccaag 13440aatttctttt ttaaggagct cggctcttaa gatgtgagtc
tgccgaagct cccggccaaa 13500gaaacctctt ctttctttaa tccggtgtct gagttttgtc
tgcggctggt cctgctacag 13560tatcacccct ggaagctact tactaggtca gctctagact
gacagatgcc ccgcatctct 13620acaaattaac ctaagatgtc gggtgcaata gctcatgtct
gcaatgccag cactttggga 13680ggccgaggca ggtggattgc ctgaggtcgg gagttcgaga
ccagcttgac caacatggtg 13740aaaccccatc tctgctaaaa atacaaaaat cagccaggca
tagtggagcg tgcctgtaat 13800cccagctact cgggaggctg aggcaggaga atcgcttgaa
cccaggaggc agaggttgcg 13860atgagctgag gtggagccac tgcactcgag cctgggcgat
aagagcaaaa ctccgtctca 13920aaaaaaaaaa attaacctca ggatgtcaca ctggggcacc
ataactcatt ccctacattg 13980caaggaagaa cgcgatcagt gctcgatgcc acttcagtaa
cccacatgaa ttcctgaaaa 14040acagctttca tcatcacccc ctctcctgat gtgcactttc
tttagaagct cccgtctcga 14100cgttgttctc cacagccact tcctaaggcg agttggaggg
tttcctgggc tgcagtcctc 14160aaatgtggct caaggaaacc ccctacttat attaattttg
tctaagttta tttccttagg 14220ttgacaatac gtatctgtgt gcatgtgtat gtgtgtccgt
atgcctatat gtgagtgtgc 14280atgtgtgtgc ctgtgtttaa acatgtacct gtgttcctgt
gtgcatggac gtgtgtctac 14340gtgtgtgcat gtgtgtacac gcgtgtgcat gtgcatgtgt
gcctgtgtac acgtgtgcat 14400atgtgcattc atgtatgtct atgtgaatag gtgcaaatgt
gtacatgtgt atgtctgtgt 14460gcatgcatgt acgtgtgtac acgtgtatac atgcattgca
tagacgtgtc tctgcgtgca 14520taggtgcaaa tgtttatgtg tgcacgtgtg tctgtgcatg
tacatgtcta cacctgtgta 14580tatctgcagg tgtatatatg tgtgcatagg tgcaaatata
tatatacatg tgtgcatgtg 14640tgtacatgtg tacacgtgtg catgtgcatg tgtacacacc
cgcacatgtg catgcatgtg 14700tatgtgcatc catgtgtgta tgagcctatg tgcatgtata
catgtgtgca ttagtatgtg 14760cctacatcca tgtatacatg tgcctgcatg tgtgtacacc
tgtgtgtgtg catgtatatg 14820catccatgtg catatgtgtg gggatgtgca tgtgtgcatg
catgtatgtg tgtgcgcatg 14880catgtgtgtg tgtatgtatg tgtctgtgtg tgcctgcatg
tgtgcctatg tgcacctatg 14940tatgtgatat ggctcggctg tgtccccacc caaatctcat
cttgaattgt agctcccata 15000attcccatct gtcatgggag ggacctggtg ggaggtcacc
gaatcacggg gcgggtcttt 15060cccatgctgt tctcgtgatc gtgaataagt ctcacgagat
ctgatggttg tacaaagggc 15120agttctccag cacacgctct gttggctgcc accatgtaac
atgtgacttt gctccgcatt 15180caccttctgc cgtgattgtg aggcctcccc agccaggtgg
aactgagtcc attaaacctc 15240ttttataaat tacccagtct cgggtatgtc tttgttagca
gcgtgagaac agaccaacac 15300agtatgcaca tgcgtatgtg tgcagatgtg catgtgtgtg
tgcagatgtg catgtgtgtg 15360tgcagatgtg cgtgtgcaga tgtgcatgtg tgcgtgtgtg
cgtgtgtgcg tgtgtgcatg 15420tatgcctgtg tatgtgtgca catgtgtgca tgcctgtgtg
tatgcatgtc tgtgcatgtc 15480catgactatg tacatatgtg tatgcacaca cgtgtgcact
gtgtgtatgt gtgtgtccac 15540atcagtgtgc tttctaggat ttccctacac ccaggattgc
tcctacagcc agcgtcccca 15600ctggggaatg cagacgccac agctcccgcc ccaccctgcc
gtcacctggg atagaggcaa 15660cggcccctgc cccaccccaa cctcacctgg gatggagagg
tggtggaggg gcacatccca 15720gagccgggga cacagtgccg acatccagtc ctcgttggca
tttctgcagt gcagcctcga 15780gaagctgttg gaagcgctca cctgcccacc catcagaggt
gagccctggg caacctgagg 15840aaggagaaga ggaaaagagg ttttttacgg tgacttcagg
tcaggagttc gagaccagcc 15900tggccaactt gacaaaaccc catctctact aaaaatacaa
aaattagctg ggcgtggtgg 15960tgggcacctg tggcacctgt catcccagct actcgggagg
ctgaggcagg agaatcgctt 16020gaacccggga ggtggaggtt acagtgagcg gagatcccgc
cactgcactc caggctgggc 16080aacaagagtg aaactccata tccaaaaaag aaaaaaaaaa
aagagagaga gagagaggaa 16140aaggggtcct tggaagcatt ttttgcagct ccaaaaaatg
tttcttgtct agcgtgaaag 16200ccctggctct tagacccggc ttggcaacct ttaatatgca
aatgcgagcc tttagctggt 16260ccagcccaca tggcgattcc caccgttgcc ctcttgccct
cgcccccacc cgtgcctgac 16320accaaggccg cccccacccg ggcctgacac caaggccgcc
cccacccggg cctggcaaca 16380cggccgcccc cacccgggcc tggcaccacg gccgccccca
cccgggcctg acaccaaggc 16440cgcccccacc cgggcctgac accacggccg cccccactac
cctcaggcgt gtggaacatc 16500atggcgccct acatttgcat attacggaac tggggtgggc
gggccaggtt tttcgcgggc 16560tacgtgaatg acaggcctgg tcagaccaat cccctcagcg
ctatgcaaat gagtcacgcc 16620tcctccaggc accgtataac acgggctggt ctcctgcctg
gggtttggag cccccgtccc 16680tctgtctcag tccaggggag ccacttcttt ctgccttctc
gccttggttt tttttttttt 16740gagacgcagt ttcgctcttg ttgcccaggc tgcagtgaaa
tggcgcgatc tcggctcacc 16800gcaacctccg cggtgctggg attacaggcg tgagccactg
cccggacctc ccttctttcc 16860tattaaactc tccgctcctt aaaaccactc cacgtgtgtc
cgtgtcgcct acacacacac 16920acacacacac acatacacac ataacagaat atatacatat
atacatatta tatacataac 16980atatatataa catatataat atatacatat aatatatatt
atacatataa tatatacata 17040tataatatat atataatata tatataacat acatgtataa
catatataca tatataatat 17100agacatatat aacacataca taacatatat acatatatac
atcactatat atacatatat 17160aagtatatat atataatata ctgttgaaaa taagggaagt
gaccctttcc ataaggacat 17220tttagacaac ttgtaaattc tttctctgcc tctgaagtgt
atataacttt tttggttggt 17280cttttttttt tttttttgac acagtttccc tctcgttgcc
caggctggac tgcaatggcg 17340cgatcgcggc tcactgcaac ctccgcctcc caggttcaag
caattctcct gcctcagcct 17400ccagagtagc tgggattaca ggcgcccgcc accacacctg
cttaattttt gtatttttgg 17460tagagacggg gtttcactat cttggtcagg ctagtcttga
actcctgacc tcaggtgatc 17520tgcctgcctc ggcctcccaa agtgctggga ttactggcgt
gagccacggt gcccagctgt 17580atgtacggtt ttttttttgt tttgttttgt tttttttaaa
gacagggttt cactcttgtt 17640acccaggctg gagtgcaatg atgcaatctc ggctcactgc
aacctccgcc tcccaggttc 17700aagcaattct cctgcctcag cctccagagt agctgggatt
acaggcgtcc gccaccacgc 17760ccggcaatgt atgtaagatt tttaatcatt tagattaaaa
ctgattagat taaaatcatt 17820agatctaatt gatttaatca aatcaattag aattgttgat
cttgagccca gaaatcagcc 17880tgttgacagt ttcacatctg aggaatgttt cctggtggac
ctgaggcctc ctcttagaaa 17940tgagacctgg aggggccggg cacggtggct cacgcctgtc
atcccatcac tttgggaggc 18000tgaggtgggt ggatcacctg aggtcagggg ttcgagacca
gcctggccaa catggtgaaa 18060ccccatttct actaaaagta caaaaagtag ccggccgtgg
tggcgcacgc ctgtaatccc 18120agctactcag gaggctgagg cttgaacccg ggaggcgggg
gctgtagtga gccacaatca 18180caccattgca ctccagcctg ggtgacaaag tgagactctg
tctcaagaaa aaagaaatgg 18240gacagagagg aagggaagaa gccccggcct cctggagaag
agacaaactt cagctgcctg 18300caaactgcaa acccaccttg agtcccacac gcagggggag
ttcggaattc gaattgttgg 18360tctcgagccc agaatgaaag gcctggtctc cctgggccgc
aagaaaggac gagatcctct 18420cggtctgcag ctcctggcgg ctgcccgcgt tggcttcaca
aggttctgta ataatcctgc 18480tgccttctct tccacactga ggccaggctt cccaggtggc
tgcagatttt gttcttattt 18540acatcttccc aaaagccttc ctcccagacc ctaagccaac
accagctaca tgaactcaga 18600tcttccctgc tgcccggaag gagggaggga gggagggagg
gagggagggt cccgggagcc 18660tgctgggccc aggaggagga gcccattctt tatcagcccg
ggggatgtca gctcagcctc 18720tttctccaag agaagcaacc acacctgtac cgcggctccg
ggtccccagg agggagctgg 18780ccccttctct gcagccagct ggaaaaggcc caggacggct
tcccctcccc ctgcacgccc 18840cccgctccgc ctgcacggcc ccccctcccc ctgcacggcc
cccctccgcc tgcacggccc 18900cccctccccc tgcacggcct cccctccccc tgcacggcct
cccttccccc tgcacggccc 18960ccctccccct gcacggcctc ccctccccct gcacggcctc
ccctccccct gcacggcctc 19020ccctccccct gcacggcccc ccttccccct gcacggcctc
ccctccccct gcacggcctc 19080cgctgccccc tgcacgtacc cccctccgcc tgcacggcct
cccttccccc tgcacggcct 19140cccttccccc tgcacggcct cccctccccc tgcacggcct
cccctccccc tgcacggcct 19200cccctccccc tgcacggcct cccctccccc tgcacgtctt
cccctccgcc tgcacggcct 19260cccttccccc tgcacggcct cccttccccc tgcacggccc
cccttccccc tgcacggcct 19320cccctccccc tgcacggcct cccttccccc tgcacggcct
ccgctgcccc ctgcacgtac 19380ccccctccgc ctgcacggcc tcccttcccc ctgcacggcc
tcccttcccc ctgcacggcc 19440ccccttcccc ctgcacggcc tcccctcccc ctgcacggcc
tccgctgccc cctgcacgta 19500cccccctccg cctgcacggc ctcccttccc cctgcacggc
ctcccctcct cctgcacggc 19560ctcccctccc cctgcacgtc ttcccctctg cctgcacggc
ctcccttccc cctgcacggc 19620ctcccttccc cctgcacggc cccccttccc cctgcacggc
ctcccctccc cctgcacggc 19680ctcccttccc cctgcacggc ctcccctcct cctgcacggc
ctcccctctg cctgcagggc 19740tgtgcagtga tctgcctgga gcatcccagc agggccgctg
tgagcctccg gatgcccagg 19800gtcccggggc cgcggggtgg aggggaggtt aaaatgcagg
tctgggcggg gcccgctggc 19860tcacgcctgt aattcgagca cttcaacact ttgggaggcc
gaggcgggcg gatcacctga 19920ggtcaggagt tcgaaaccgg cctggccaac atggcaaaac
cccatcactg gtaaaaatac 19980aaaaatcatt tagccgtgct ggcgcgcgcc tgtagtccca
gctactggga ggctgaggca 20040ggagaatcgc ttgaacccgg gaggcggagg ttgcagtgag
ccgagatcgc gccattgcac 20100tccagcctgg gagacagagt gagactcccg ttcaaaaaca
aaaaaccttc gtctccacat 20160cctcttatct taatgcagat attcctttct actaataact
ctttttttct tctttttttt 20220tttttcagag acagggtctc gctctgttgc gcagactggt
gtgcagtgtc atgatctcag 20280cttactgcag cctccgcctc ctggattcaa gctattcgcc
tgcctcagcc tccagcacag 20340ctgggattac aagcacttgc caccattccc agctaatttt
ttgtattttt ggtagcaacg 20400ggggtctcac catgttggcc aggctggtct cgaactcctg
acttcaggtg atccgcccgc 20460cttggcttcc caaagtgctg ggatgacagg cgtgagccac
cgtgcccggc ctaataataa 20520ctctttcaac caattgccag tcagaaaatt ttaaaatcta
ccttatgacc tggaagcccg 20580cctcaccacc agtggagcag tcccaccttc accgattgaa
cctgtcaggc ctctgagccg 20640aagctcagcc attatcaccc ctgtgacttg cacatatacg
tccaggtggc ctgcaggagc 20700caagaagtct ggagcagcca aggaaaaacc acagagaagt
aaaacagcca gttcctgcct 20760taactggtta actaaaatta caacatttta ctatcgtgag
ttctccctgc cctaccttag 20820ccgatcaatc gactttgtgc cgttcgtcct ctggacaatg
agtcttatga tctgtgcacc 20880acgcaccttg caatccctcc tctgctgaca atagataacc
accttttgct gtaattttcc 20940attacctacc caactcctat tgagccaccc ctcccccatc
tcccttcgct gactctctct 21000tcggactcag cccacttgca cccaagtgaa tgaaccgctt
tatcgctcac acaaagcctg 21060ttcgggggtc tcttcgcacc gacgcgcttg acagaaccaa
ggttcgtctt acacgtatgg 21120attcatgtct gacgtttcct taaaatgcat aataccaaga
tgtcctccga ccacctaggg 21180cacaggtcgt caggacctcc tgaggctcgg tcacaggcgc
gtcctcaacc ttagcaaaac 21240acactttttt tttttttttt ttgagacgga gtcttgctct
gtctcccagg ctggagtgca 21300gtggtgcaat ctcggctcac tgcaacctcc gcttcccagg
ttcaagcaat tctcctatct 21360cagcctccca agtagctggg actacaggcg cccaccacca
cacccaggta atttctgtat 21420ttttagtaga gacagggttt caccttgttg gtcaggctgg
tcttgaactc ctgacgtcag 21480gtgatctgcc cgccttggcc tcccaaagtg ctgggatgac
aggcgtgagc caccgtgccc 21540ggccagcaaa acacactttc taaatgtcct gagacctgtc
tcagatactt tttggttcag 21600aagactcgag gaaatcagtg tctcctagga caggctggac
ccaaagctgt acactcacat 21660cctctgtgtc atgacggatt ccatccattc cggctactgt
catactccct ccctcccatc 21720acagtccctt cccccgtcac agtccctccc ctcccgtcac
cttcatcata tcccaggtcc 21780cctgaccact gaggggtgtc ccctcctgtc cccacgtccc
ccgacccctc ccctcacatc 21840ccaagtcccc tgaccactga ggggtgtcca ctcctgtccc
cacacctgtc cccatgtcct 21900cctgagccct ccctcacatc ccaggtcccc tgaccactga
ggggtgtccg ctcctatccc 21960cacacctgtc cccacattcc ccctgacccc tcccctcaca
tcccaggtcc cctgaccact 22020gaggggtgtc ccctcctatc cccacacctg tccccacgtt
ccccctgacc cctcccctca 22080catcccaggt cccctgacca ctgaggggtg tccactcctg
tccccacacc tgtccccatg 22140tcctcctgag ccctcccctc acatcccagg tcccctgacc
actgaggggt gtccactcct 22200gtccccacgt gccctgaccc ctcccctcac atcccaggtc
ccctgaccac tgaggggtgt 22260ccactcctgt ccccacgtgc cctgacccct cccctcacat
cccaggtccc ctgaccactg 22320aggggtgtcc actcctgtcc ccacacctgt ccccatgtcc
tcctgagccc tcccctcaca 22380tcccaggtcc cctgaccact gaggggtgtc cactcctgtc
cccacgtgcc ctgacccctc 22440ccctcacatc ccaggtcccc tgaccactga ggggtgtcca
ctcctgtccc cacacctgtc 22500cccatgtcct cctgagccct cccctcacat cccaggtccc
ctgaccactg aggggtgtcc 22560actcctgtcc ccacgtgccc tgacccctcc cctcacatcc
caggtcccct gaccactgag 22620gggtgtcccc tcctgtcccc acacctgtcc ccacgttccc
caacccctcc cctcacatcc 22680caggtcccct gaccactgag gggtgtcccc tcctatcccc
acatctgtcc ccacgttccc 22740cctgacccct cccctcacat cccaagtccc ctgaccactg
aggggcgccc cctcctgtcc 22800ccaggtcccc cgacgccttc cccacacatg acaaagtgga
gcaggaagga gccccggggg 22860cggcccccac tcccagccac ctctgccatc tcgtccggac
ggcacagcgg agtggggtct 22920ggaggccgtc ccacggagca ctgacccttc ctgggggagg
tcctctccac cctggccttc 22980acggtcgcgg cgggacagcg cagatgacgg acgggcccag
acgcccggtg acccgccagg 23040cggggtgaga cacctacacc ttcccgcccg ctgagtcctc
gggagactca cgtcccagag 23100gcgtgagtgg ccgtgacgcg cacattcaac gcacggggtg
aatggttgct gggtgaatca 23160acggaaggac aggggtgctc agatcccagc attcccagtg
ccccaacatc cccaccgtcc 23220cagctgtccc gacccgtccc cacgcaggcc ccggcggcag
ggtgaggacg tccaaccggc 23280caagcaagtc gtggcccccg ggctcatttc ataaccgtcc
tgggctgttt ccacactggc 23340tccgcggctc tgacccggca gagaattcac ggtctgcaag
gggtgcaggc cgcctgtggc 23400tgccaacgtc caggccacag atcccaggcg accctccccc
tgaaccccct gcccgtgccc 23460ccagctaagg gtcccaggag gaggagaagg agcctcaatg
acggaagcgc gggttcctga 23520ttcccagccc acaacaggca cagacggcac ccgccacgtc
ccccgtaggg gacttgccat 23580caggagaacg gggtagacac actcaccttc cagccgctgg
aatcccagag ctcctggcag 23640ctcccgccgg gtctctgcgg gacactcttc ctaaaacaca
cccagtccgc tgcgattggc 23700tgtggcgcgg acactcctgc caccaggagg agggacagcc
cgcccccgcc acggatctgt 23760ccccaccgca ggagcgggac cggctgggct gcaaacaccg
ccctgaactc ccacggggac 23820cccacagacc aggactgggg accggaagac ccctcccagg
ggaccccacg gtgtgtccca 23880acaaggtgtc cccggggtcc cccggtcagg ggcttagaga
cagcaaggac gtcccagagg 23940tgtgtgccca cgggttctct gtggtcagag gggcccttgc
aggggacatt gaggtgtctg 24000actgacgggc cccactcggg ccactggccg cggctgcggt
gggtctcccg gagcccccag 24060gacggggtga acaggtgctt tcatctcggc cctggggtca
acgcatgggg ccggcagtcc 24120caagcctgca ggctctgagc gccttggcca gcaaacccac
cgggatcttc cccctgcagg 24180ttccgacctc tcccgccccg cgtggcccgg accctgggca
gcccgtgccg cctccgtcgg 24240tggaagtggc tcctcccagc gcagcccacg cctgcgatct
ccccccccga gccaacctgg 24300agctgaccag gagcccaggt caggggtctg tccagggccc
cgttcctgcc tcctcctggc 24360tgcttccggt ccaccccgca ggtgctcccc acgcaccccg
ctgtctccca ccccgggctg 24420gactccagga cagggccagt gtgggcttca gagagtgcac
ggaacgtttg ggggccgcag 24480tggacggctc aaagggctgc cttgggatcc catgttcccg
ggtggaattc tcccgcatag 24540ccacggctgg ggcttctctc cctgcacccc atttctgtcc
cggctccctg tttcctccct 24600caccccagct gtggggtacc ttgagggcgg ctgctgtcct
ggcacaggga catctggtcg 24660gcctacaagc cacaggccac cggcctctcc gcctctttcc
atcctaactc aggccccgtc 24720acctccccac actccgccct cccccctgct cctcctcccc
ctcctccttc ctccccctgc 24780tccttctcca tcctctccct ccttcttcct gtccattgag
actccccctc tctgcccaaa 24840gccccctgtg gcttcctctt ggcccatctg tttcctccct
ccccctcctc cctcctcctc 24900ctccctcctc ccttcactga ggccctgcgg ggacaccagc
ctcctggttc ccgcctcctt 24960ccacagccct gggagagtct ataaaatgac ctgtgccctg
gtgtggcacg ggagcaggaa 25020gcggcttcca cgcctcctcc cacagtcaca gggcccggcc
cttcctcccg ctgtgcccca 25080gagtcatgag gaccagaggt cacagggccc ggcccttcct
ctgtgtcctg gtgtgatgtg 25140gactgtggtc acagggcccg gcccttcctc tgtgtcctgg
tgtgatgtgg actgtggtca 25200cagggcccgg cccttcctcc gtgtcctggt gtgatgtgga
ctgtggtcat gaggcccggc 25260ccttcctctg tgtcctggtg tgatgtggac tgtggtcaca
gggcccggcc cttcctctgt 25320gtcctggtgt gatgtggact gtggtcacgg ggcccggccc
ttcctctgtg tcctggtgtg 25380atgtggactg tggtcatgag gcctggccct tcctctgtgt
cctggtgtga tgtggactgt 25440ggtcacaggg cccggccctt cctctgtgtc ctggtgtgat
gtggactgtg gtcacagggc 25500ccggcccttc ctccgtgtcc tggtgtgatg tggactgtgg
tcatgaggcc cggcccttcc 25560tctgtgtcct ggtgtgatgt ggactgtggt cacagggccc
ggcccttcct ccgtgtcctg 25620gtgtgatgtg gactgtggtc acagggcccg gcccttcctc
tgtgtcctgg tgtgatgtgg 25680actgtggtca tgaggcctgg cccttcctct gtgtcctggt
gtgatgtgga ctgtggtcac 25740ggggcccggc ccttcctctg tgtcctggtg tgatgtggac
tgtggtcacg gggcccggcc 25800cttcctctgt gtcctggtgt gatgtggact gtggtcacgg
ggcccggccc ttcctctgtg 25860tcctggtgtg atgtggactg tggtcacggg gcccggccct
tcctctgtgt cctggtgtga 25920tctggactgt ggtcacgggg cccggccctt cctctgtgtc
ctggtgtgat ctggactgtg 25980gtcacgaggc ccggcccttc ctctgtgtcc tggtgtgatg
tggactgtgg tcacagggcc 26040cggcccttcc tctgtgtcct ggtgtgatct ggactgtggt
cacagggccc ggcccttcct 26100ctgtgtcctg gtgtgatctg gactgtggtc atgaggcctg
gcccttcctc cgtgtcctgg 26160tgtgatgtgg actgtggtca cagggcccgg cccttcctct
gtgtcctggt gtgatgtgga 26220ctgtggtcac agggcccggc ccttcctccc gctgtgcccc
agagtcatga ggaccagagg 26280tcacagggcc cggcccttcc tctgtgtcct ggtgtgatgt
ggactgtggt cacagggccc 26340ggcccttcct ctgtgtcctg gtgtgatgtg gactgtggtc
acagggcccg gcccttcctc 26400tgtgtcctgg tgtgatgtgg actgtggtca cggggcccgg
cccttcctct gtgtcctggt 26460gtgatgtgga ctgtggtcac ggggcccggc ccttcctctg
tgtcctggtg tgatgtggac 26520tgtggtcacg gggcccggcc cttcctctgt gtcctggtgt
gatctggact gtggtcacgg 26580ggcccggccc ttcctctgtg tcctggtgtg atctggactg
tggtcacgag gcccggccct 26640tcctctgtgt cctggtgtga tgtggactgt ggtcacaggg
cccggccctt cctctgtgtc 26700ctggtgtgat gtggactgtg gtcacggggc ccggcccttc
ctctgtgtcc tggtgtgatg 26760tggactgtgg tcacggggcc cggcccttcc tctgtgtcct
ggtgtgatgt ggactgtggt 26820catggggccc ggcccttcct ctgtgtcctg gtgtgatgtg
gactgtggtc atgaggcccg 26880gcccttcctc tgtgtcctgg tgtgatgtgg actgtggtca
cagggcctgg cccttcctct 26940gtgtcctggt gtgatgtgga ctgtggtcat gaggcctggc
ccttcctccg tgtcctggtg 27000tgatgtggac tgtggtcaca gggcctggcc cttcctctgt
gtcctggtgt gatgtggact 27060gtggtcacag ggcccggccc ttcctctgtc ctggtgtgat
gtggactgtg gtcacagggc 27120ccggcccttc ctctgtgtcc tggtgtgatg tggactgtgg
tcacagggcc cggcccttcc 27180tctgtgtcct ggtgtgatgt ggactgtggt catgaggcct
ggcccttcct ctgtgtcctg 27240gtgtgatgtg gactgtggtc acagggcccg gcccttcctc
tgtgtcctgg tgtgatgtgg 27300actgtggtca cagggcccgg cccttcctct gtgtcctggt
gtgatgtgga ctgtggtcat 27360gaggcctggc ccttcctctg tgtcctggtg tgatgtggac
tgtggtcatg aggcctggcc 27420cttcctctgt gtcctggtgt gatgtggact gtggtcacag
ggcccggccc ttcctctgtg 27480tcctggtgtg atgtggactg tggtcacagg gcccggccct
tcctctgtgt cctggtgtga 27540tctggactgt ggtcatgagg cccggccctt cctctgtgtc
ctggtgtgat gtggactgtg 27600gtcacagggc ccggcccttc ctctgtgtcc tggtgtgatg
tggactgtgg tcacggggcc 27660cggcccttcc tctgtgtcct ggtgtgatgt ggactgtggt
cacggggccc ggcccttcct 27720ccgtgtcctg gtgtgatgtg gactgtggtc acagggcccg
gcccttcctc cgtgtcctgg 27780tgtgatgtgg actgtggtca tgaggcccgg cccttcctct
gtgtcctggt gtgatgtgga 27840ctgtggtcac agggcctggc ccttcctctg tgtcctggtg
tgatgtggac tgtggtcatg 27900aggcccggcc cttcctctgt gtcctggtgt gatgtggact
gtggtcacag ggcccggccc 27960ttcctctgtg tcctggtgtg atgtggactg tggtcatgag
gcccggccct tcctctgtgt 28020cctggtgtga tgtggactgt ggtcatgagg cccggccctt
cctctgtgtc ctggtgtgat 28080gtggactgtg gtcacagggc ccggcccttc ctccgtgtcc
tggtgtgatg tggactgtgg 28140tcacagggcc cggcccttcc tctgtgtcct ggtgtgatgt
ggactgtggt cacagggccc 28200ggcccttcct ccgtgtcctg gtgtgatgtg gactgtggtc
acagggcccg gcccttcctc 28260tgtgtcctgg tgtgatgtgg actgtggtca tgaggcccgg
cccttcctct gtgtcctggt 28320gtgatgtgga ctgtggtcac agggcccggc ccttcctctg
tgtcctggtg tgatgtggac 28380tgtggtcaca gggcccggcc cttcctctgt gtcctggtgt
gatgtggact gtggtcatga 28440ggcccggccc ttcctctgtg tcctggtgtg atgtggactg
tggtcacagg gcccggccct 28500tcctctgtgt cctggtgtga tgtggactgt ggtcacaggg
cccggccctt cctctgtgtc 28560ctggtgtgat gtggactgtg gtcacagggc ccggcccttc
ctctgtgtcc tggtgtgatg 28620tggactgtgg tcacagggcc tggcccttcc tcccgctgtg
ccccagggtc atgaggaccg 28680gaggtcacag tgcccggccc ttcctctgtc ctggtgtgat
gtggactgtg gtctcggggc 28740ccagcccttc ctccctctgt gtcctgggcg gccaggtgtg
ggctggacac gaggggagga 28800catcacgtgg gctgagggac gtgtcgtccg tgcctcggtg
ctgcctgtgt tctgcgagcc 28860gagggttgtg aagggtgctt gagtgaagtg ggccaagtgt
gagcccctgt aaatggctgt 28920gacttccctg ttgaccgtgc ccttgtgtcc gacaaggggt
gtttgcaaac ccctcccaag 28980gccgggcacg gaagcccttg gtccagctgc ttcctggaat
ggaaaaccct ctcctgcact 29040agaaaatccc atgaccccgc gtttgagttt cgaatattta
gcatggggag cacccctcca 29100atggctagga gagacaccag gcggagataa aggtttgact
atttaccagt cctgcatcca 29160cggccggcct gcaggcccca cccaggcgga ggtaaggatt
tgattattta tggatcccgg 29220gtgctgcagg ccccacccag gcggaggtaa ggatttgatt
atttatgggt cccgggtcct 29280gcaggtccca cgcaggcgga ggtaaggatt tgattattta
tgggtcccgg gtgctgcagg 29340ccccgcccag gcggaggtaa ggatttgatt atttatgggt
cccgggtgct gcaggcccca 29400cccaggcgga ggtaaggatt tgattattta tgggtcccgg
gtgctgcagg ccccacccag 29460gcggaggtaa ggatttgatt atttatgggt cccgggtgct
gcaggccccg cccaggcgga 29520ggtaagggtt tgattattta tgggtcccgg gtgctgcagg
tcccacgcag gcggaggtaa 29580ggatttgatt atttatgggt cccgggtgct gcaggcccca
cccaggcgga ggtaaggatt 29640tgattattta tgggtcccgg gtgctgcagg tcccacgcag
gcggaggtaa ggatttgatt 29700atttatgggt cccgggtgct gcaggcccca cccaggcgga
ggtaaggatt tgattattta 29760tgggtcccgg gtgctgcagg ccccgcccag gcggaggtaa
ggatttgatt atttatgggt 29820cccgggcgct gcaggcccca cccaggcgga ggtaaggatt
tgattattta tggatcccgg 29880gtgctgcagg ccccacccag gcggaggtaa ggatttgatt
atttatgggt cccgggtcct 29940gcaggccccg cccaggcgga ggtaaggatt tgattattta
tgggtcccgg gcgctgcagg 30000ccccacccag gcggaggtaa ggatttgatt atttatgggt
cccgggtcct gcaggccccg 30060cccaggcgga ggtaaggatt tgattattta tgggtcccgg
gtgctgcagg ccccacccag 30120gcggaggtaa ggatttgatt atttatgggt cccgggtcct
gcaggcccca cccaggcgga 30180ggtaaggatt tgattattta tgggtcccgg gtcctgcagg
ccccacccag gcggagctaa 30240ggatttgatt atttatgggt cccgggccct gcaggccccg
cccaggcgga ggtaaggatt 30300tgattattta tgggtcccgg gtcctgcagg ccccacccag
gcggaggtaa ggatttgatt 30360atttatgggt cccgggcgct gcaggcccca cccaggcgga
ggtaaggatt tgattattta 30420tgggtcccgg gtgctgcagt ccccgcccag gcggaggtaa
ggatttgatt atttatgggt 30480cccgggtgct gcaggcccca cccaggcgga ggtaaggatt
tgattattta tgggtcccgg 30540gtcctgcagg ccccacccag gcggaggtaa ggatttgatt
atttatgggt cccgggtcct 30600gcaggccccg cccaggcgga ggtaaggatt tgattattta
tgggtcccgg gtcctgcagg 30660ccccgcccag gcggaggtaa ggatttgatt atttatggat
cccgggtcct gcaggccccg 30720cccaggcgga ggtaaggatt tgattattta tgggtcccgg
gtgctgcagt ccccacccag 30780gcggaggtaa ggatttgatt atttatgggt cccgggtcct
gcaggccccg cccaggcgga 30840ggtaaggatt tgattattta tgggtcccgg gtgctgcagg
ccccgcccag gcggaggtaa 30900ggatttgatt atttatgggt cccgggtcct gcaggccccg
cccaggcgga ggtaaggatt 30960tgattattta tgggtcccgg gtcctgcagg ccccacccag
gcggaggtaa ggatttgatt 31020atttatggat cccgggtgct gcaggcccca cccaggcgga
ggtaaggatt tgattattta 31080tgggtcccgg gcgctgcagg ccccacccag gcggaggtaa
ggatttgatt atttatgggt 31140cccgggtcct gcaggcccca cccaggcgga gctaaggatt
tgattattta tgggtcccgg 31200gtcctgcagg tcccacgcag gcggaggtaa ggatttgatt
atttatgggt cccgggtcct 31260gcaggccccg cccaggcgga ggtaaggatt tgattattta
tgggtcccgg gtgctgcagg 31320ccccacccag gcggaggtaa ggatttgatt atttatgggt
cccgggtgct gcaggcccca 31380cccaggcgga ggtaaggatt tgattattta tgggtcccgg
gtgctgcagg ccccgcccag 31440gcggaggtaa ggatttgatt atttatgggt cccgggtgct
gcaggccccg cccaggcgga 31500ggtaaggatt tgattattta tgggtcccgg gtcctgcagg
ccccacccag gcggaggtaa 31560ggatttgatt atttatgggt cccgggtgct gcaggccccg
cccaggcgga ggtaaggatt 31620tgattattta tgggtcccgg gtcctgcagg ccccgcccag
gcggaggtaa ggatttgatt 31680atttatgggt cccgggtgct gcaggcccca cccaggcgga
ggtaaggatt tgattattta 31740tgggtcccgg gtcctgcagg tcccacccag gcggaggtaa
ggatttgatt atttatgggt 31800cccgggccct gcaggcccca cccacactgg gtggtgagga
atgcagcaga gagggaccct 31860gggccagcac ctttattggg tccaaggtat tatcccaccc
tgtttccggc tcgcagttgt 31920cacgggtggt tgagagccag cagggagggt ctctgagagg
tggcaccgtg cgggcgtcgc 31980cgggaacaga ggcacaaagc tgggagcccc ggacccgggt
ttcaacagca tggggcagcc 32040gcacggctca cggggcctca ggccgggccg tgacgggctc
agagcacacc tgcgtgagcc 32100gagaccggag gctacgtgat ctcattctgc aggtgcgatt
cccgaagctg ctctgttccg 32160agctgccttg tttaaaaccg tcgccgggcc gggcgtggtg
gctcacgcct gtcatccgaa 32220cactctggga ggcccagacg cgtggattgc ctgagctgag
ctctggagtt cgagaccagc 32280ctgggcaaca tggtgaaatc ccgtctctac taaaaaaaaa
aaaaaaaaaa aaaatagccg 32340ggcgaggtgg cgggtgcctg taatcccagc tactccagag
gctgaggcag agaatcgctt 32400gaaaagggga ggcggaggtt gcagtgagcc gagatcgcgc
ccctgcactc cagcttggtc 32460tccgtctcaa aaaataaaaa ataaaagtaa agtcatcaat
tctgttttcc cctgtccttg 32520ccgagaagca aaatgacatg aaaaggatag agaattgtgt
ctccgaagct gagtcttacc 32580cctttaccag agaaaagaca caactttggg aggccaaggc
gggcggatgg ccaacatgat 32640gaaaccttgt ctctaccaaa aaaaaaaaaa tacaaaattt
agctgggcct ggtggcacgc 32700gtctgtaatc ccatctaccg ggaaggctga gataatcgcg
gctcactgca acctccatct 32760cccgggttca agcgattctc ctgcctcagc ctcccaagta
gctgggatta caggcacccg 32820ccaccacgcc cggctaattt agtagagaca gggtttcatc
atgttggcca ggctggtctc 32880aaactcccga cctcaggcaa tccgcccacc ttggcctccc
aaagtgctgg gatgacaggc 32940gtgagccacc gcacccggcc agagatactg atttttatga
gcaacacgta taggcttcct 33000aaatcacacc gctggaaaaa gtattctcca cgtctgtagc
tcctctctct gctggtttgg 33060gggttcagga agcagggcgc gattttgcat tataagtatc
gactaaagaa tggtaaggct 33120ggctgggtgc agcggctcac gcctgtcatc ccagcagttt
gggaggctga ggcaggtgga 33180tccgtgaggt cgggagttca agaccagcct ggccaacatg
gtgaaacccc gtctctacta 33240aaaatacaaa aattagccag ccatagtggt gaatgcctgt
aatcccagct actggggagg 33300ctgaggcggg agaattgcgt gaacccagga ggcagaggtt
gcagtgagtc gaggttgtgc 33360cactgcactc cagcctgggc tgcaatagtg aaactccatc
tcaaaaaaaa aaaaaaaaaa 33420ggacaggtgc ggtgcctcac gcctgtcatc tcagcacttt
gggaggctga ggcgggcaga 33480tcacttcagg tcaggagttc gagaccaaaa atataaaaaa
ttagccgggt gtggtgatgc 33540tcacctgtaa tcctagctcc ttgagaggct gaggcaggag
aatcacttga acccggaagg 33600cggaagttgg agtgagccaa gatctagcca tggcactcca
gcgtggggga cagaaccaga 33660ctctgtttca aaaaaacaaa caaacaaaca aaaaacaaaa
caaaaaaaga atggtgaggc 33720tgcaaaggac agctttgttt ctcataaggg gttaggcgca
ggggagctat tcctacagcc 33780tgggaagcag agtcagaagc cagaagcaga cacctccaga
gaggggcaga aggaacagga 33840atcagccggg cgcgatggct cacgcctgtc atcccagcac
tttgggaggc cgaggcaggt 33900ggatcacgag gtcaggagat cgacaccatc ctggctaaca
cggtgaaacc ccgtctctac 33960taaaaataca aaaaattagc cgggcgtggt ggcgggcgcc
tgtagtccca gctactcggg 34020aggctgaggc aggagaatgg cgtgaacccg ggaggcggag
cttgcagtga gtggagatcg 34080tgccattgca ctccagcctg ggggacagca atagactccg
tctccaaaaa gaaaagaaaa 34140gaaaaaaaga aagaagaaag agagagagag agagagggag
ggagggaggg aaggaaaaga 34200aagagaaaga aaaaagtgcc cgtttcctct ggcacaaggg
tgcccgtgcc acagctgagc 34260tggagaagga agtcagggat gaggagtgga gtcaggtatg
cggccctctc acccctgatg 34320ccaggcgcac ctgcccacct ggtcccatgc taatcattca
tactccaagt ccccacgctt 34380aaaattgtaa cacagcccta aatgtcccaa aatgtcctct
gatcacacac agcaggagaa 34440tcactcgact ttgcatagag ttgtcaaaac acatacaaat
atatgctacc acacaccggt 34500attgaacgtt aaaatcgatt accattttcc actgatcaag
tcaacagaga ttgaaaaacc 34560agcacttttg ggagaggccg aggcaggcag atcgcttgag
cccaggagtt ccagacgagc 34620ctgagcaaca tggcaagacc ctgtctctac aaaaaatata
aaaattagct gggcgtagtg 34680gtgtgcactt gtaggaccag ctacagagac ctcttccctc
ctcctgtagt cccagctact 34740caggaggctg aggagggagg atcacttgag tctaggaggt
cgaggctgca ctccagcctg 34800ggggacacag tgaaatcctg tgtctaccaa aaaaggtgaa
aagagaaact tctgtctaca 34860atattgatgg ttcctgaagt tgcctcccaa catattttaa
gttcggccta aagatttctc 34920tgtacatagt gaactgtgac gtaacaggag gtgtcaacag
accagaacct actcttgtgg 34980caatcactga atctcagcca aaggcagcca aatgttccaa
ccgggttcaa acaaggtaaa 35040cgccaaccca cacccaatgc agctgtttct ctgctttctg
tgtgtcctgt ccttttcttt 35100ctttctttct atctttcttt ctttcttttt ctttctttct
ttcttttctt tctttccttt 35160ctttctttct tctttctttc tttctttctt ttctttcttt
cttttctttc tctctctctc 35220tttctttttc tttctttctt ctttctttct ttcttttttt
ttgtggaaac agagtctcgc 35280tctgtcaccc aggctggagt gcaatggcgc gatctcgggt
cactgccagc tccgcctccc 35340gggttcacgc cattctctgc ctcagcctcc tgagtagctg
agactacagg caccagccat 35400catgcccggc taattttttg tatttttagt agagacgggg
tttcactgtg ttagccagga 35460tggtctcgat ctcctgacct cgtgatccac ccacctaggc
ctcccaaagt gctgggatga 35520caggcctgag ccaccgcgcc cggcccactt tattttattt
tttattttta tttttcagac 35580agaatctcgg tctgtcaccc aggctggagt gcaatggcgc
gatctcggct cactgcaacc 35640ttcacctcct gggttcaagc gattctcctg cctcagcctc
ccaaagtgct gagattacag 35700gcatgagcca ccgcacccag cctaagactt atttttcttc
cacatcccca aaactacagc 35760gtctgcaaat ccacacgggc gttcccgacc ggacctggat
tccccactgt ccccaaccct 35820gccccttaga ggcggttcag acgccgccga ccttgaagcc
aacgacagac acctgttgtt 35880tccacgcagg gaagaagcca cagctcaggg tacaagaagc
ctgtgctggc tcaggttgat 35940cttttttctt ttatttttga gacagagtct cactctgtct
cccaggctgg agtgcagtgg 36000cacgatcttg gctcactgca acctccgcct tccaggttca
agtgattctc ctgcctcagc 36060ctcccaagtg agtacctggg attacaggtg cccgccacca
cacccggcta attttttgta 36120tttttagcag agactgtttt tcaccatgtt ggccaggctg
gtctcgaact cctgacctca 36180tgtgatccac ctgcctcggc ctcccaaagt gctgggatta
caggcgtgag ccaccgcgtc 36240cggcccctga ttcagttttt gaccacagct ggtttcctct
tttatttcag gtatacaggc 36300catatacact gattgttgta aaatatattc catcttactc
ttcttcatat acacatatat 36360atatttcatt tccttttttg agacactcca gcctgggtga
aagagcgaga ctccatctca 36420aaaataaata aataaataaa taaataaata aataaataaa
ataaaaaata aaactccgcg 36480gccgggcgcg gtggctcacg cctgtcatcc cagcactttg
ggaggccgag gcgggtggat 36540cacgaggtca gaggatggag accatcctgg ctaacatggt
gaaacctcgt ctctactaaa 36600aatacaaaaa atcagccggg tgtggtggcg ggcgcctgta
gtcccagcta ctcgggaggc 36660tgaggcagaa ttacttgaac ccgggaggtg gaggttgtgg
tgagccgaga tcacgccact 36720gcactccagc ctgggtgaca gacctagaga gagagattat
ctcaaaaaaa aaaaaaaaaa 36780aagatcctgc caagcttgtg actactaaat gccactgcag
tgcacacttt gaaatgggta 36840agttgacatt atataatttc acattgaatg attaaaaaca
aaaatgcaaa ttgtatgtaa 36900aattcaatga ttaattaaat tgcaaattga atgattacaa
ataagtattg actatgaata 36960ggttaccttt tctgaagaat aggagaggtt aaaaaagaca
ttttttcctt ttttacttta 37020taaacatctt tacagttgaa tttttatttt tatttattta
taattattat tttttgtaga 37080gacaggacct ggctatgttg ccccggctgg tctctaaatc
tggggctcaa gcgatccccc 37140aacctcagcc tcccaaggtg ctgggattac aggcgtgagc
cacttcaccg gcctgtttgc 37200attttaaaaa taagcttgca tcacttttta gataaaaatt
aactacagat aacctcaact 37260gaccctagca ggaactggag tctctgctcc tcctctgagg
ccctcagctc cccgtgggtg 37320ggggctctct aggcagcccc caggaacagg tgggcctcct
tggtaacccc cagagacccc 37380caaccctggc atcctgcagg gtggccgggc agggagggag
ctagggagct gggcaaggcg 37440ggtcccacag gaaagggctc tactccctga gattgaaacc
atttttgcaa aaacaatttt 37500tctttctttt tttttttttt aagacagagt ctcgctctgt
cacccaggct gcagggcagt 37560ggcgcgatct cggctcactg caaccttcgc ctcccatgtt
cgagccattc acctgtctca 37620agctcctggg tagctgggac cacaggcacc caccaccata
ctcggctagt tttcgtattt 37680ttattagaga cggggtttta ccacattggc caggctggtc
tcaaacccct gacgctgtga 37740tcctcccacc tcagcctccc agagtggtgg gattacaggc
atgagccacc gcgcccggcc 37800tgataaaatt gtaagtgaga acattagggc agtgaaggag
agctaacctc actgagtccg 37860tcttgcttcg aacttccacg ctgtctgcaa gctgtctcca
agctgtctcc aagctgtcct 37920tcttcactca tgggtgtcac ccacactatc tttgggagga
acttagttta tagtttagct 37980ttgacacgaa gatgataata gccctttccc agtgcaaacc
tccttcttgc ctggggacta 38040ggccgtgttt acaggactaa gagattatcc cctggattag
aaatgatggt ttaggactct 38100ggcctctgga ggctgcaagt ttctgaccct cctcaaattg
ctcctgctca catcgctttt 38160gtgaaaccta caatcagtgc tgagatatgt cacagaccct
tcactggacg gatcagctgg 38220caccacccag atgatcaacc ggctaatctg gtctgcggcc
cccacccagg aactgactca 38280gcgccagacg acagcttcga ctccctgtga ttccatctct
gacccaacca atcagcactc 38340cccactttct gacctcctac ccagcaaatt atcctgaaaa
actccagtcc cagggtctct 38400ggggagacgg atttgaggaa taaggaaact ccggcctccc
acgcagccgg ctgggattgc 38460agctttgtgg tagtgataaa tcactctgtc cacgcagccg
gcgaggtgag ccccttgggc 38520ggtgacagga agaccaagga ggataaagaa aagccagctc
ctgggggcgc gaggtcacag 38580ccgtggctcg gacgggaacc ccaaggtcaa aggatagcag
gggcaggagg tgccggcctt 38640ggaaggcagc ggcagattcc acagaagcct ctggagtcct
cgtcccaggc agacgccgtg 38700caccgcctgg aggtggtggg aagagcgcac acagcttgca
aaggccgggg tacgtcgcca 38760gaggggcaca ggcgcaaggg ggcctggctg gcccagaaga
ggggtccccg gaaccccagg 38820tccatgtcag ggccggagcc tgcccagatc cattttccct
gctgattccc aaggtgctct 38880gtgcccccag agaactgctt tgaaacccac atacctcacg
gtggggccca ccccaaaagc 38940ccatccctgg gcttcatgag gtgtggtttg agaccctata
tttttttctg ttttgagacg 39000gagtttcgct cttgttgccc gggctggagt gcaatggtgc
catctcggct cactgcaagc 39060tccgcctccc gggttcaagc gattctcctg cctcagcctc
cggagtagct gggatgacgg 39120gcacccgcca ccatgtctgg ctaatttctt ttatttttag
tagagacggc gtttcaccat 39180cttggccagg ctggtcttga actcctgacc tcgtgatcca
cctgcctcag cctcccaaag 39240tgctgggatt gcaggcttca tttttttttt tttttttttt
tttttgagat ggagtctcgc 39300tctgtcgccc aggctggagt gcagtggcgt gatctcggct
caccacaacc tccacctcct 39360gggttcaagc aattatttat ctgcctcagc ctcccgagta
gctgggacta caggcacccg 39420ccaccacacc cggctaattt tttgtatttt tagtagagac
ggggtttcac caggttagtc 39480aggatggtct cgacctcctg acctcgtgat ccgcctgcct
tggcctccca aagtgctggg 39540attacaggcg tgagccactg cgccccgcta ttgttctaag
cctaaagggg gaaggccttg 39600tgagctgtgc ttcgtactgg tttttttttc acattacacc
aggttcaagc aattctcctg 39660cctcagccag gctggtctca aactcctgac ctcatgatcc
gcccacctcg gtctcccaaa 39720gtgctcggat tacaggtgtg agccaccgcg cccggccaca
gttaaccatt ttcaccgtgc 39780ccggccagaa ttaactattc taatgggtcc attcactagc
atttagcacc tgtttccgca 39840ggggccgggt ctgtgcaaac cacaccccgg aggtcgagga
agctgagagc tgaaggaaga 39900agctgactaa tccagattct ccgaaagaaa tacttagcag
agatgtaaga acagaagccg 39960tgtctgcgag gagagtggat cccggtcgtc cctgcagacc
cagggcttca ccccagggag 40020gaatatgcag gaaaacgttg gtgggaggga ggggggccct
cacggtcagg gaaggtgcct 40080cagggacagc cacgtgcacc tgccccaggg cagggtttat
ggtccaggct attgaggtca 40140cattggagaa agtagcaaaa tcatcttaga gaccttccca
gagcagcggt tggtcagaag 40200tgaacaggtg gatcagcatt ccagatggag ttgctctctc
ttccacaaac actcactgtc 40260agatgcaacc cccactctct ctagctaccc cccccagcta
cccccactgt ctctagctcc 40320ccccactgtc tctagctacc ccacctctct ctagctatcc
ccccctctag ctacccccac 40380tgtctctagc tccccccact gtctctagct acccccgcct
ctctctagct atccccctct 40440ctaactactc cccacctctc tctagctatc cccctctcta
gctaccccac ctctctctag 40500ctatccccct ctctagctac cccacctctc tctagctacc
cccacctctc tctagctacc 40560ccccccagct acccccactc tctctagcta ccccacctct
ctctagctat ccccctctct 40620agctacccca cctctctcta gctaccccca cctctctcta
gctacccccc ccagctaccc 40680ccactctctc tagctacccc acctctctct agctatcccc
ctctctagct accccacctc 40740tctctagcta tccccctctc tagctacccc acctctctct
agctatcccc ctctctagct 40800accccacctc tctctagcta tccccctctc tagctacccc
acctctctct agctaccccc 40860ccctctctag ctatccccac tctctctagc tatccccctc
tctagctacc cccactgtct 40920ctagctacac cccctctagc tacccccact gtctctagct
ccccccactc tctctagcta 40980ccccacctct ctctagctat ccccctctct agctaccccc
actctctagc taccccacct 41040ctctgtagct accccacctc tctctagcta cccccctctc
tttagctcca gcacattctc 41100atgactccac aaggagacca tgtgtcagaa ccccgttcct
tttcatggct gcatactatt 41160ccactctgtg gacagagcac attttgtgtg tcccttcctc
tcatgacggc ctgtgctctc 41220tcctgaatgc accatgcatg caggtgacgt gtgtgcaaag
ccattgcctg gcaggtccca 41280gagaccctct gctggctccc aagcaggtcc cctcccacct
cacgggtgac cacgctgagg 41340ttcaggacag atgaggcagg ttgctgagat gaggggcaag
cccagccctg tgggggccca 41400gctgggtgcc cgggtggctc acgtcaccag aggggcctcc
tgctgcacct ttgagccaat 41460ggcactgagc atggggtggg tctctatgag ctggttcaca
cagacacccc cacacccacc 41520ccatggatgt gggagcctcc accatttccc ctaggggttc
gcagcctctc cccaactaga 41580gaccccctcc ctgggagtcc ctcaagggct ccccaccccc
atacccatac accattgcag 41640tgttggcagc tggaagcccc ccaggggccc ttagggacct
gaggacagga atggagggag 41700gaagcttccc tgtgtgtggt tcctgtttgc tctgtgaggt
gaggtgtgga cacccacagt 41760cagcaggtca gagggacctg caaggtcagg cagcgtctcc
caggctggcc aggggccagg 41820gttagggttg gaagaccggg atggtctgtg gaatccccat
gctcaccccc caccgccgat 41880taccctggga gggcagtggc cacagtcagg tcccagcagc
agagcccagc tctgggggtg 41940gatgcagggg gtgctgcagg ggccggctgt accatcccag
gcggtcttgg ggggtcacga 42000tgtccccaac acggtgggag ggaggcagag gcccccctca
aactcctgac ctcaggtgat 42060ccaaccgcct cagcctccca aagcgccggg atcacaggca
tgagccaccg tgcccggcca 42120ctttccgctt atttttacag cactgatttt gcagaagtct
tttgctttag ggccctggcc 42180ccggccccta tgccacctcg cacccctcca cccctctctg
cccggatcct ggcctccccg 42240tactcatcca ggctgccctc agccttccca tgcagtcctg
gacaatacaa ggagctccgt 42300ccacactggc tccggcacgt ggagagggaa acctggctcc
tcggctcaag gaaagtactt 42360tttttttttt tgagatggag tttcactctt gtcgcccagg
ctggagcgat ctcggctcac 42420tgcaacctcc acctccccgg ttcaagcgat tctcctgcct
cagcctcccg agtagcggga 42480attacaggtg cccgccacca cgcccagcta atttttgtat
ttttagtaca gatggggttt 42540tgccaagttg gccaggatgg tctcaaactc ctgaactcag
gtgatccacc cgcctctgcc 42600tcccaaagtg ctgggattac gggcgtgagc caccgcgccc
agccaagcaa agtatttttt 42660aaagctctgt cttgtggtaa atctcacagc aggtgaaagc
atctcgattc atagaataac 42720ctgggcgttg gcctcacagt tgcagcagca accagccggg
cctcccgtcg caactccatc 42780cgagctccca gactccccac cctcctgtcc accctgcctg
gcttgagaca ggtggatcac 42840ctgaggtcag gagttcaaga gcagcctggc caacacggtg
aaacctcatc tctactaaaa 42900atataaaaat tagccgggcg tggtggctca cacctataat
cccagcactt tgggaggctg 42960aggcgggcgg atcgggaggt caggagttcg agaccagcct
ggccaacatg gcaaaaccct 43020aaaagaacaa aaattagccg ggcgtggtgg cgggcgcctg
tggttccagc tacttgggag 43080gctgaggcag gagaatcgct agaacccggg aggcggaggt
tgcagtgagc tgagtttgtg 43140ccactggact ccagcctggg tgacagagca acactccgtc
tcaaaaaaaa aaacacaaag 43200tgctaattat atatatattt accacaattt ggaaacattg
ttcgccgggc gcagtggctc 43260acgcctgtca tcccagcact ttgggaggcc gaggcgggcg
gatcatgagt tcaggagatt 43320gagaccatcc tggttaacac agtgaaaccc cgtctctact
aaaaatacaa aaaattagcc 43380aggcgtggtg gcgggcgcct gtagtccgag ctactcggga
ggctgaggca ggagaacggc 43440gtgagcccgg gaggcggagc ttgcagtgag ctgagatcac
accactgcac tccagcctgg 43500gcgacagagc gagactccgt ctcaaaaaaa ataaaatgct
cattatatac atatttacgc 43560caattagaaa accttgttca tcctatcagt cacttctggg
cggggagtta gaattccgca 43620gagacgcctt ctgtctcgca cagatgactt ctgggagggc
cggtgagctt acggggccat 43680gaggtgtgta agggggatct gcacagcccc aggcaggact
tatgccacac agaggcccag 43740tgcttggtcc ctcggctgtg actgacgtcc ccacggcagc
cacaaccgag ctgactttga 43800agaacggctg cctttattgc ccgctgtgaa cccgacgctg
ctgcgggaat gagcgtgcgg 43860ggggccgctg acgccggccc agcacccccg cacggaggcc
aacgcacgaa gctgccctgg 43920gagcggctct cggctcagcc agtgaagggg taaacggggg
cctcctctca ccccaaagcc 43980cgtgacccct ggatggagcc gggatgctgc gatcagttcc
aaggctgtgg ccgaaacacc 44040gtgttaccgg cagagtaagg ccagaacaat gctggaggct
ttaaaaccca cacgttaaaa 44100acacaatttt tgtttgtttg tttgttttga gacggagtct
cgctctgtcg cccaggctgg 44160agtgcagtgg cacgatctcg gctcactgca acctccgcct
cccaggttca tgccattctc 44220ctgcctcaga ctcccgagta gctgggacta caggcaggtg
ccaccacgcc cagataattt 44280tttttttgta ttttttagta gagacggggt ttcaccaggt
tagccaggat ggtctcgatc 44340tcctgacctc atgatcctcc tgcctcggcc tcccaaagtg
ctgagatgac aggcatgagc 44400cactgggccc ggcctaaaaa cacaatttct atctaacacc
cgggggcata aaacctttga 44460aactggccgg gcgcagcggc tcgcacctgt catcccagca
ctttgggagg ccgaggccgg 44520cggatcacct gaggtcggga gttcgagacc agtctgacca
acatggtgaa accccgtctc 44580tactaaaaat acaaaattag ccgggtgtgg tggtgcctcc
ctgtaatccc agctactcag 44640gcggctgagg tgagagaatc acttgaaccc aggaggcgga
ggttgcagtg agccgagatc 44700acgccactgc actgcagccc aggcaacagg agcgaaactc
catctcaaaa aaaaaaagtt 44760tggaaacgtt tgttttctag gaaacagaaa caataacctc
cgtctgtctg cagacatcgc 44820ccaccctgcc cgagcttccc accgaggtta aagatgagct
ctcgcccgcg gccccaggag 44880ggactctcgg cagaaaaccc ttacggaacc ttgaagatgt
gtccagcccg gggctcccgt 44940aacaagtgct ccggactcag gcggtccgcc gcggaggtca
cgtagaggtt gtcgtagccg 45000ggtccccgaa gcagcaggag gtgaccctgt acacaggcag
ctccaccgtg cacagcacct 45060tccctgtgag cgagcgtggg ggctgagcct gagcacccca
ggccgcctgc ctggccgttc 45120ctcctgaccc tgggcccaac ccccgggcag catgggtgtc
tctgtggcac ctggagctgc 45180cagattggca cctgcctagc caggcccagc cgcacctgct
ctagtgagct ctgtagtctc 45240cccagattca tgccaagtag gatctcagaa tgggaaatta
tttggaaata gggtgtttgc 45300agaggtaatt agtaggtcag agcaggttag ggtgggtcct
acatccaatc accagtgtcc 45360ttctaagaga cagaagagca gacacagaca cagaggagga
ggccacgtgg agacggaggc 45420agagactgga gtgatgcggc ctcaagccca gggatgcctg
gagcccccag gagctgggag 45480aggcaggaag gaccctcccc tagagtctca atacaattga
agtggattga actgtggttc 45540ccaaaaagat ctgtctacac cctaatatcc acaacctagg
aatgagacct tgtatagaaa 45600tagggtgttt caagatctag ttagtgaagg atcttgagat
gagatcatcc tggagtaggg 45660tggatcctaa atgcaatgac aggtgtcctt ctagagacag
aagaggagac acagacacag 45720tggatgaggc ctcgtggaga cggaggcaga gactggagtg
atgcggccac aagcccaggg 45780acgcctggag cccccaggag ccgggagagg caggaaggac
cctccactac agctcctgga 45840gggagtacgg ccctgaaact cctcggtctc agactcctgc
tctgcaggac tgggggaggt 45900gacttcctgt ttcttaggca gccagtcctt ggttgcggca
gccccaggac ctagcacacc 45960tgcagaggga acctgggagt ccgtgccgtc gggaaacgga
ggccccttag tctctacaaa 46020ttcgcgattg ctgcccggcc ccgacttctg aagccagaac
gctgcagacg cagtggacac 46080ccgatgtggc caagcctcat acggccccgc catccggcac
acacctgtct cggggtcaag 46140gcgtatcacc ttgcctctat cgacgcagag gccacccaga
gcttccccgc agcgtccacg 46200cacacgccgg ccggcatgcc ctgctccgga tgcagccggt
acaggagcct ccggttcact 46260gcaatgagag gaccgggatg ggcaggggcc ttcccagccc
tggtgagtgc cctgctgagt 46320gccaggagca ggcagacctc aggcaggccc gtgaccctcc
tggatgtgag tggagcctgg 46380aggaggtgca cctagctcgt tgggagcctt ggacgtggct
ggatcctgat gcgtacagac 46440cccgtttggc gaacagctgt aggctgaaaa ttaatgtccc
caaatacagc tgaccagggc 46500acacacctcc tcaaacgccg gcccaaggac atcacccttt
aaacagcatc caatctctct 46560cctagttccc accgaggatt atgaacgaag ccttgatgta
cacctgttga ctttgtggaa 46620gatgggagac ttctctccca acccgaagca cttccagccc
agaaacccca gtgacacctg 46680gtcgaaggcc ttgtaccttg gcctttcttt cctcaggtgg
aaatgagaag aaagaacatg 46740gccccaagga cagacaccag ataactgggg acttggctgt
ccaccagctg ggaactgaga 46800gttatgcctg ctccagtggc ccatcctgct agaaaaaaga
tgtctttacc aggaaaacgg 46860gatgtggcag tcctcaccca cccacaggat gacctggtcc
ccaccaacat ccagggataa 46920ccttgaaccc atcgacatcc agggataacc ttgtcccagt
caacatccag ggatgacttt 46980gtccccaccc acatgtggag gtgacctcgt ccccatcaac
attcaccaaa catgcagaga 47040tcaccttgtc cccaccaacg tccggggata atcttgtcct
catcaacata caggactgac 47100cttgtcccga taagcaccca gggatgacct tgtccccact
aacaagcaga gataaccttg 47160tcccaatcaa catccaggat gaccttgtcc ccactgacat
gcagagatca ccttatcccc 47220accaacatcc agggataacc ttgagtcaat caacatccag
gatgacctca tccccaccca 47280catgcagaga tcaccttgtt cccaccaaca tccggggata
accttgaatc aatcaacaac 47340cttgaaccaa tcaacatcca ggatgacctt gtccctatca
acatccagga cgaccttgtc 47400cccacccaca tgcagagatc accttgtccc caccaacatc
cagggataac cttgtcccaa 47460tcaacatcca ggatgacctt gtccaccacc cacatgcgga
gatgacctcg tccccatcaa 47520cattcaccaa acatgtagag atcaccttgt ccccaccaac
atccaaggtt aaccttgaac 47580caatcaacat caggatgacc ttgtccccac ccacatgcag
agatgacctc gtccccatca 47640acattcacca aacatgcaga gatccccttg ctctcgccaa
cgtccgggga taatcttgtc 47700cccatcaaca tccagaatga ccttgtcttc accaacatcc
gggactgacc ttgtcctgat 47760aagcacccag ggatgaactt gtccccacta acaagcagag
atgaccttgt cccaatcaac 47820atccaggatg acttcgtccc catcgatatg cacagattct
agggaaaaga aagagagatc 47880agactgtcac tgtgtctatg tagaaaggaa agacataaga
gactccattt tgaaaaagac 47940ctgtccttta aacaattgct ttgctgagat gttgttaatt
tgtagctttg ccccagccac 48000tttgccccaa cctggagctc acaaaaacat gtgttgtatg
aaatcaaggt ttaagggatc 48060cagggcggtg caggacgtgc cttgttaaca agatgttcac
gagcggtata cttggtaaaa 48120gtcatcgcca tcctctagtc tcaataaacc aggggcacag
tgccctgcgg aaagccgcag 48180ggacctctgc tcttgaaagc cgggtattgt ccaaggtttc
tccccatgtg atagtctgaa 48240atatggcctc gtgggaaggg aaagagctga ccatccccca
gctcaacacc cataaagggt 48300ctgtgctgag gaggattagt aaaagaggaa ggcctctttg
cagttgagat aagaggaagg 48360catctgtctc ctgctcgtcc ctggacaata gaatgtctcg
gtgtaaaccg attgtatatt 48420ccatctactg agatagggta aaactgcctt atggctggag
gtgggacatg ctggcggcaa 48480cactgctctt taaggcgttg agatgtttat gtatgtgcac
atcaaagcac agcacttttt 48540tctgtacctt gtttatgatg cagagacatt tgttcacgtt
ttcctgctga ccctctctcc 48600actattaccc tattgtcctg ccacatcccc ctctccccga
taatgatcaa taagtactaa 48660gggaactcag aggcaggtgc cggcgcgggt cctctgtatg
ctgagcgccg gtcccctggg 48720cccatttttc tttctctcta ctttatctct gtgtctcttt
cttttttcaa gtctctcgtt 48780cctcctgatg agaaatgccc acaggtgtgg aggggcaggc
caccccttca aggatgcaca 48840tggaaggatg cacagaggag gatgcacatg ggaggatgca
catgagttgt acagaatgga 48900tgagtcccta cacacaggag actccttcct gtcacaacct
gagacccgct cttcctgtca 48960cggcccgaga caccctcttc ctgtcacggc ccgagacccc
ctcttcctgt cacggcccga 49020gaccccctct tcctgtcacg gcccgagact ccctcttcct
gtcacggccc gagactccct 49080cttcctgtca caacctgaga cccgctcttc ctgtcacggc
ccgagacccg ctcttcctgt 49140cacggcccga gactccctct tcctgtcacg gcccgagatc
ccctcttcct gtcacggccc 49200gagactccct cttcctgtca cggccggaga ccccctcttc
ctgtcacggc ccgagacccc 49260ctcttcctgt cacggcccga gaccccctct tcctgtcacg
gcccgagacc ccctcttcct 49320gtcacggccc gagaccccct cttcctgtca cggcccgaga
ccccctcttc ctgtcacggc 49380ccgagactcc ctcttcctgt cacggcccga gatcccctct
tcctgtcacg gcccgagacc 49440ccctcttcct gtcacggccg gagaccccct cttcctgtca
cggcccgaga ccccctcttc 49500ctgtcacggc ccgagacccc ctcttcctgt cacggcccga
gactccctct tcctgtcacg 49560gcccgagact ccctcttcct gtcacaacct gagacccgct
cttcctgtca cggcccgaga 49620cccgctcttc ctgtcacggc ccgagactcc ctcttcctgt
cacggcccga gatcccctct 49680tcctgtcacg gcccgagact ccctcttcct gtcacggccg
gagaccccct cttcctgtca 49740cggcccgaga ccccctcttc ctgtcacggc ccgagacccc
ctcttcctgt cacggcccga 49800gaccccctct tcctgtcacg gcccgagacc ccctcttcct
gtcacggccc gagaccccct 49860cttcctgtca cggcccgaga ctccctcttc ctgtcacggc
ccgagatccc ctcttcctgt 49920cacggcccga gaccccctct tcctgtcacg gccggagacc
ccctcttcct gtcacggccc 49980gagaccccct cttcctgtca cggcccgaga ctccctcttc
ctgtcacggc ccgagacccc 50040ctcttcctgt cacggcccga gaccccctct tcctgtcacg
gcccgagacc ccctcttcct 50100gtcacggccc gagactccct cttcctgtca cggcccgaga
ctccctcttc cggtcacggc 50160ccgagatccc ctcttcctgt catggcctga gttgtttttc
aggtttcttt gggatcccct 50220tggctacaaa caggtccact cagtcagctg aggggcttag
aattctattt ttggtttacc 50280ccactatcag gaggttgtct gagataagcc agcccctccc
acccttgcag gcacagtgtg 50340caagcataag atctcgtgct ggccgccatt caggtggcag
ccacagggat ggtccagacg 50400tggctctcca accgtcctta gaccacacaa agctttagga
tttctggggt cccaatgcag 50460actctaaagg ttgcatagtc tggtctctat ctgccctcaa
tgagacctag gcccagtgca 50520gactctaaag gttgcatagt ctggtcccta tctgccctca
atgagaccta ggcccagtgc 50580agactcgaaa ggttgcacag tctgctctct atctgtcctc
aatgagactt aggcacaatg 50640cagactctaa acgttgcaca gtctgctctc tatctgccct
caatgagacc taggcccaat 50700gcatactcta aaggttgcac agtctgctct ctatctgccc
tcaatgagac ctaggcccaa 50760tgcagactct aaaggttgca tagtctggtc tctatctgcc
ctcaatgaga cctaggccca 50820atgaagactc taaaggttgc gcagtctgct ctctatctgt
cctcaatgag acctaggccc 50880agtgcagact ataaaggttg cacagtctgg tctctatctg
tcctcaatga gacctaggcc 50940caatgcagac tctaaaggtt gcacagtctg ctctctatct
gtcctcaatg agacctaggc 51000caagtgcaga ctctaaagct tgcacagtct gctctctatc
tgacctcaat gagacctagg 51060cccaatgcag actataaagg ttctacagtc tgctctctat
ctgtcctcaa tgagacctag 51120gcccaatgca gactctaaag gttgcacact ctggtctcta
tctgtcctca atgagaccta 51180ggcccagtgc agactgtaaa gtttgcatag tctgctctct
atctgtcctc aatgagacct 51240aggtccaatg cagactctaa aggttgcaca gtctgctctc
tatctgtcct cgatgagacc 51300taggcctagt gcagactcta aaggttgcac agtctgctct
ctatctgctc tcaatgagac 51360ctaggcccaa tgcagactct aaaggttgca cagtctgctc
tctatctgtc ctcaatgaga 51420cctaggccca atgcagactc taaaggttgc acagtctgct
ctctatttgt cctcaatgag 51480acccaggccc aatgcagact ctaaaggttg cacagtctgc
tctctatcgg tcctcaatga 51540gaccgaggcc ctatgcagac tctaaaggtt acacagtgtg
ctctctatca gtcctcagtg 51600agacctagac ccaatggaga ctctaaagtt tgcaaagtct
gctctctatc tctcctcagt 51660gagacctaga cccaatgcag actctaaagg ttgcacagta
tggtctctat ctgccctcaa 51720tgagacctag gctcagtgca gactttaaag tttgcacagt
ctgctctgta tctgtcctca 51780atgagaccta ggcccaatgc agactctaaa ggttgcacag
tctgccctct atctgtcctc 51840aatgagacct aggcccaatg cagactctaa agttttaaca
gtctggtctc tatctatcct 51900caatgagacc taggcccaat gccgaatcta gaggttgcac
agtgtgctct ctgtctgctc 51960tcaatgagac ctagacccaa tgcagactct aaaggttgca
cagtctgctc tctaactgcc 52020ctcaatgaga cctaagccca atgcagactc taaaggttgc
acagtctggt cgctatctgt 52080cctcaatgag acccagaccc aatgcagact ctaaaggttg
cacagtctgc tctatatctg 52140tcctcaatga gacctaggaa aagtgccgac tctaatggtt
gcctagtctg ctctttatct 52200gtcctcaatg agacctaggc ccaatgcaga ctctaaaggt
tgcacagtcc ggtctctatc 52260tgtcctcaat gagacctagg cccaatgccg actctaaagt
ttgcacagtg tgctctctat 52320ctgctctcaa tgagacctag gcccaatgca gactctacag
gtagcacagt ctgctctcta 52380actgccctca atgacaccta ggcccaatgc agactctaaa
cgttgcatag tctggtctct 52440acctgccctc aatgagacct aggcccaatg cagactctaa
aggttgcaca gtctgctctc 52500tatctgtcct caatgagacc taggccaagt gcagactcta
aagcttgcac agtctgctct 52560ctatctgacc tcaatgagac ctaggcccaa tgcagactac
aaaggttcta cagtctgctc 52620tctatctgtc ctcaatgaga cctaggccca atgcagactc
taaaggttgc acactctggt 52680ctctttctgt cctcaatgag acctaggcca aatgcagact
ctaaaggttg cacagtctgc 52740tctctaactg tcctcaatga gacataggcc caatgcagac
tctaaaggtt gcacagtctg 52800ctctctatgt gtcctcaatg agacctaggc tcagtgcaga
ctctaaaggt tgcatagtat 52860gctctctatc tgtcctcaat gagatctaag cccaatgcag
actctaaggg ttgccgagcc 52920tgctctctat ctgccctcaa tgagacctag gcccaatgca
gactctaaag gttgcacagt 52980ctgctgtcta tctgacctca aggagaccta ggcccaatgc
agactctaaa ggttgcacag 53040tctggtctct atctgtcctc aatgacacct aggcccagtg
cagactctaa agtttgcaca 53100gtctgctctc tgtctgtcct caaagagacc taggcccagt
gcagactcta aaggttgcac 53160agtctgctct ctatctgtcc tcaatgagac ctaggcccaa
tgcagactct aaaggttgca 53220cagtctgctc tctatctgcc ctcaatgaga cctaggccca
atgcaaactc taaagttgca 53280cagtctggtc tctatctgtc ctcaatgaga cctaggccca
atgcggactc taaaggttgc 53340acagtgtgct ctccatctgt cctcaatgag acctaggccc
aatgcagact ctaaaggttg 53400cacagtctgc tctctatctg ccctcaatga gacctaggcc
caatgcagac tctaaaggtt 53460gcacagtctg ctctctatct gctctcaatg agacctaggc
ccaatgcaga ctctaaaggt 53520tgcacagtct ggtctctatc tgtcctgaat gaggcccagg
cccaatgcag actgtaaagg 53580ttgcacagtc tgctctctat ctgtcctcaa tgagacctag
gctcagtgca gcctctaaag 53640tttgcatagt ctgctctcta tctgtcctca atgagaccta
ggtccaatgc agactctaaa 53700ggttgcacag tctgctctct atctgtcctc aatgagacct
aggcctagtg cagactctaa 53760aggttgcaca gtctgttctc tatctgtcct caatgagacc
taggccaagt gcagactcta 53820aagcttgcac agtctgctct gtatctgacc tcaatgagac
ctaggcccaa tgcagactat 53880aaaggttcta cagtctgctc tctatctgtc ctcaatgaga
cctaggccca atgcagactc 53940taaaggttgc acactctggt ctctatctgc cctcaatgag
acctaggccc aatgaagact 54000ctaaaggttg cgcagtctgc tctctatctc tcctcaatga
gacctaggcc caatgcagac 54060tctaaaggtt gtacagtctg ctctctatct gtcctcaatg
agacctaggc ccaatgcaga 54120ctctaaaggt tgcacagtct gctctctatt tgtcctcaat
gagacccagg cccaatgcag 54180actctaaagg tggcacagtc tgctctctat cggtcctcaa
tgagaccgag gccctatgca 54240gactctaaag gttacacagt gtgctctcta tctgtcctca
gtgagaccta ggcccaatgc 54300agactctaaa gtttgcgcag tctgctctct atgtgtcctc
aatgagacct agggccagtg 54360cagactctaa aggttgcata gtctgctctc tatcagtcct
cagtgagacc tagacccaat 54420ggagactcta aagtttgcaa agtctgctct ctatctctcc
tcagtgagac ctagatccaa 54480tgcagactct aaaggttgca cactctggtc tctttctgtc
ctcaatgaga cctaggccaa 54540atgcagactc taaaggttgc acagtctgct ctctaactgt
cctcaatgag acataggccc 54600aatgcagact ctaaaggttg cacagtctgc tctctatgtg
tcctcaatga gacctaggct 54660cagtgcagac tctaaaggtt gcatagtatg ctctctatct
gtcctcaatg agatctaagc 54720ccaatgcaga ctctaagggt tgccgagcct gctctctatc
tgccctcaat gagacctagg 54780cccaatgcag actctaaagg ttgcacagtc tgctgtctat
ctgacctcaa ggagacctag 54840gcccaatgca gactctaaag gttgcacagt ctggtctcta
tctgtcctca atgacaccta 54900ggcccagtgc agactctaaa gtttgcacag tctgctctct
gtctgtcctc aaagagacct 54960aggcccagtg cagactctaa atgttgcaca gtctgctctc
tatctgtcct caatgagacc 55020taggcccaat gcagactcta aaggttgcac agtctgctct
ctatctgccc tcaatgagac 55080ctaggcccaa tgcaaactct aaagttgcac agtctggtct
ctatctgtcc tcaatgagac 55140ctaggcccaa tgcggactct aaaggttgca cagtgtgctc
tccatctgtc ctcaatgaga 55200cctaggccca atgccgactc tagaggttgc acagtgtgct
ctctatctgc tctcaatgag 55260acctaggccc aatgcagact ctaaaggttg cacagtctgc
tctctaactg ccctcaatga 55320gacctagacc caatgcaaac tctaaaggtt gcacagtctg
gtcgctatct gtcctcaatg 55380agacccaggc ccaatgcaga ctctaaaggt tgcacagtct
gctctatatc cgtcctcaat 55440gagacctagg accagtgccg actctaatgg ttgcctagtc
tgctctttat ctgtcctcaa 55500tgagacctag gcccaatgca gactctaaag gttgcacagt
ccggtctcta tctgtcctca 55560atgagaccta ggcccaatgc cgactctaaa gtttgcacag
tgtgctctct atctgctctc 55620aatgagacct aggcccaatg cagactctaa aggtagcaca
gtctgctctc taactgccct 55680caatgacacc taggcccaat gcagactcta aacgttgcat
agtctggtct ctatctgccc 55740tcaatgagac ctaggcccaa tgcagactct aaaggttgca
cagtctgctc tctatctgtc 55800ctcaatgaga cctaggccaa gtgcagactc taaagcttgc
acagtctgct ctctatctga 55860cctcaatgag acctaggccc aatgcagact ataaaggttc
tacagtctgc tctctatctg 55920acctcaatga gacctaggcc caatgcagac tataaaggtt
ctacagtctg ctctctatct 55980gtcctcaatg agacctaggc ccaatgcaga ctctaaaggt
tgcacagtct gctctctaac 56040tgtcctcaat gagacatagg cccaatgcag actctaaagg
ttgcacagtc tgctctctat 56100gtgtcctcaa tgagacctag gcccagtgca gactctaaag
gttgcatagt atgctctcta 56160tctgtcctca atgagatcta agcccaatgc agactctaag
ggttgccgag cctgctctct 56220atctgccctc aatgagacct aggcccaatg cagactctaa
aggttgcaca gtccgctctc 56280tatctgtcct caatgagacc taggcccaat agagactcta
aaggttgcac agtctgctct 56340ctatctgtcc tcaatgagac ccaggcccaa tgcagactct
aaacgttgca tagtctgctc 56400tctatctgtc cgcaattaga cctagaccca atgcagactc
taaaggttgc acagtctgct 56460gtctatatga cgtcaaggag acctaggccc aatgcagact
ctaaaggttg cacagtctgg 56520tctctatctg tcctcaatga cacctaggcc cagtgcagac
tctaaagttt gcacagtctg 56580ctctctgtct gtcctcaaag agacctaggc ccagtgcaga
ctctaaaggt tgcacagtct 56640gctctctatc tgtcctcaat gagacctagg cccaatgcag
actctaaagg tggcacagtc 56700tgctctctat ctgccctcaa tgagacctag gcccaatgca
aactctaaag gttgcacagt 56760ctggtctcta tctgtcctca atgagaccta ggcccaatgc
ggactctaaa ggttgcacag 56820tgtgctctcc atctgtcctc aatgagacct aggcccaatg
cagactctaa aggttgcaca 56880gtctgctctc tatctctcct caatgagacc taggcccaat
gcagactcta aagtttgcac 56940agtcggctct ctatctgccc acaatgagac ctaggcccaa
tgcagactct aaaggttgca 57000cagtctgctc tctatgtgtc ctcaatgaga cctaggccca
gtgcagactc taaaggttgc 57060acagtctgct ctctatctgc cctcaatgag acctaggccc
aatgcagact gtaaaggttg 57120cacagtctgc tctctatctg ctctcaatga gacctaggcc
caatgcagac tctaaaggtt 57180gcacagtctg gtctctatct ctcctgaatg aggcccaggt
ccaatgcaga ctgtaaaggt 57240tgcacagtct gctctctatc tgtcctcaat gagacctagg
ctcagtgcag cctctaaagt 57300ttgcatagtc tgctctctat ctgtcctcaa tgagacctag
gtccaatgca gactctaaag 57360gttgcacagt ctgctctcta tctgtcctca atgagaccta
ggcctagtgc agactctaaa 57420ggttgcacag tctgctctct atctgccctc aatgagacct
aggcccaatg cagactctaa 57480aggttgcaca gtctgctctc catctgtcct caatgagacc
taggcccaat gcagactcta 57540aaggttgcac agtctgctct ccatctgtcc tcaatgagac
ctaggcccaa tgcagactct 57600aaaggttgca cagtctgctc tctatttgtc ctcaatgaga
cccaggccca atgcagactc 57660taaaggttgc acagtctgct ctctatcggt cctcaatgag
accgaggccc tatgcagact 57720ctaaaggtta cacagtgtgc tctctatctg tcctcaatga
gacctaggcc caatgcagac 57780tctaaagttt gcgcagtctg ctctctatct gtcctcaatg
agacctaggg ccagtgcaga 57840ctctaaaggt tgcatagtct gctctctatc agtcctcagt
gagacctaga cccaatgcag 57900actctaaagt ttgcaaagtc tgctctctat ctctcctcag
tgagacctag acccaatgca 57960gactctaaag gttgcacagt atggtctcta tctgtcctca
atgagaccta ggcccagtgc 58020agactctaaa ggttgcacag tctgctctct atcggtcctc
aatgagacct aggcccaatg 58080cagactctaa agtttgcaca gtctgccctc tatctgtcct
caatgagacc taggcccagt 58140gcagactcta aaggttgcac agtctgctct ctatctgtcc
tcaatgagac ccaggcccaa 58200tgcagactct aaaggttgca cagtctgctc tatatctgtc
ctcaatgaga cctaggacca 58260ctgccgactc taatggttgc ctagtctgct ctctatctgt
cctcaatgag aactaggccc 58320aatgcagact ctaaaggttg cacagtctgg tctctatctg
tcctcaatga gacctaggcc 58380caatgccgac tctaaaggtt gcacagtatg ctctctatct
gctctcaatg agacataggc 58440ccaatgcaga ctctaaaggt tgcacagtct gctctctatc
tgccctcaat gagacctagg 58500cccaatgcag actctaaagg ttgcacagtc tgctctccat
ctgtcctcaa tgagacctag 58560gcccaatgca gactctaaag gttgcacagt ctgctctcta
tttctcctca atgagaccca 58620ggcccaatgc agactctaaa ggtggcacag tctgctctct
atcggtcctc aatgagaccg 58680aggccctatg cagactctaa aggttacaca gtgtgctctc
tatctgtcct cagtgagacc 58740taggcccaat gcaaactcta aagtttgcgc agtctgctct
ctatctgtcc tcaatgagac 58800ctagggccag tgcagactct aaaggttgca tagtctgctc
tctatcagtc ctcagtgaga 58860cctagaccta atgcagactc taaagtttgc aaagtctgct
ctctatctct cctcagtgag 58920acctagaccc aatgcagact ctaaaggttg cacagtatgg
tctctatctg ccctcaatga 58980gacctaggcc cagtgcagac tctaaaggtt tcacagtctg
ctctctatct gtcctcaatg 59040agacctaggc ccaatgcaga ctctaaagtt tgcacagtct
ggtctctatc tgtcctcaat 59100gagacctagg cccaatgccg actctagagg ttgcacagtg
tgctctctat ctgctctcaa 59160tgagacctag gcccaatgca gactctaaag gttgcacagt
ctgctctcta actgccctca 59220atgagaccta ggcccaatgc agactctaaa ggttgcacag
tctgttctct atctgtcctc 59280agtgagacct aggccaagtg cagactctaa agcttgcaca
gtctgctctc tatctgacct 59340caatgagacc taggcccaat gcagactcta aaggttgcac
agtctgctct ctatctgtcc 59400tcaatgagac ctaggcccaa tgcaaactct aaaggttgca
cactctggtc tctttctgtc 59460ctcaatgaga cctaggccaa atgcagactc taaaggttgc
acagtctgct ctctaactgt 59520cctcaatgag acataggccc aatgcagact ctaaaggttg
cacagtctgc tctctatgtg 59580tcctcaatga gacctaggcc cagtgcagac tctaaaggtt
gcatagtatg ctctctatct 59640gtcctcaatg agatctaggc ccaatgcaga ctctaagggt
tgccgagcct gctctctatc 59700tgccctcaat gagacctagg cccaatgcag actctaaagt
ttgcacagtc cgctccctat 59760ctgtccttaa tgagacctag gcccaataga gactctaaag
gttgcacagt ctgctctcta 59820tctgtcctca atgagaccca ggcccaatgc agactctaaa
cgttgcatag tctgctctct 59880atctgtccgc aattagacct aggcccaatg caaactctaa
acgttgcaca gtctgctgtc 59940tatctgtccg caattagacc taggcccaat gcagactcta
aaggttgcag agtctgctgt 60000ctatctgacc tcaaggagac ctaggcccaa tgcagactct
aaaggttgca cagtctggtc 60060tctatctgtc ctcaatgaca cctaggccca gtgcagactc
taaagtttgc acagtctgct 60120ctctgtctgt cctcaaagag acctaggccc agtgcagact
ctaaaggttg cacagtctgc 60180tctctatctg tcctcactga tacctaggcc caatgcagac
tctaaaggtt gcacagtctg 60240atctctattt gtcctcaatg agacccaggc ccaatgcaga
ctctaaaggt tgcacagtct 60300gctctctatc ggtcctcaat gagacctagg cccaatgcag
actctaaagg ttgcacagtc 60360tgctctctat ctgccctcaa tgagacctag gccctatgca
aacgctaaag gttgcacagt 60420gtggtctcta tctgtcctca atgagaccta ggcccaatgc
agactctaaa ggttgcacag 60480tgtgctctcc atcagtcctc aatgagacct aggccaaatg
cagactctaa aggttgcaca 60540gtctgctctc tatgtgtcct caatgagacc taggcccagt
gcagactcta aagtttgcac 60600agtctgctct ctatcggccc tcaatgagac ctaggcccaa
ttcagactct aaaggttgca 60660cagtctgctc tctatctgct ctcaatgaga cctaggccca
atgcaaactc taaaggttgc 60720acagtctggt ctctatctct cctgaatgag acccaggccc
aatgcagact gtaaaggttg 60780cacagtctgc tctctatctg tcctcaatga gacccaggcc
cagtgcagac tgtaaagttt 60840gcatagtctg ctctctatct gtcctcaatg agacctaggt
ccaatgcaga ctctaaaggt 60900tgcacagtct gctctctatc tgtcctcgat gagacctagg
cctagtgcag actctaaagg 60960ttgcacagtc tgctctctat ctgccctcaa tgagacctag
gcccaatgca gactctaaag 61020gttgcacagt ctgctctcta tttttcctca atgagaccca
ggcccaatgc agactctaaa 61080ggttgcacag tctgctctct atctgtcctc aatgagaccg
aggccctatg cagactctaa 61140aggttacaca gtgtgctctc tatctgtcct cagtgagacc
taggcccaat gcagactcta 61200aagtttgcgc agtctgctct ctatctgtcc tcaatgagac
ctagggccag tgcagactct 61260aaaggttgca tagtctgctc tctatcagtc ctcagtgaga
cctagaccca atggagactc 61320taaagtttgc aaagtctgct ctctatctct cctcagtgag
acctagaccc aatgcagact 61380ctaaaggttg cacagtctgg tctctatctg ccctcaatga
gacctaggct cagtgcagac 61440tttaaagttt gcacagtctg ctctgtatct gtcctcaatg
agacctaggc ccattgcaga 61500ctctaaaggt tgcacagtct gccctctatc tgtcctcaat
gagacctagg cccaatgcag 61560actctaaagt ttcaacagtc tggtctctat ctgtcctcaa
tgagacctag gcccaatgcc 61620gactctagag gttgcacagt gtgctctcta tctgctctca
atgagaccta gacccaatgc 61680agactctaaa ggttgcacag tctggtctct atctgccctt
aatgagacct acactcccag 61740gagtctgcag aacagggtgt gtgtaagttt tctggggccg
ctcaaggaaa cgggggatta 61800aaaaatatta tcctcacagt gctggcatgt tggcctacac
agagccctgc tcgccgtgaa 61860cgtcaggact tcctgcgtga tctcttcaag tccgattggg
agccctttga ctcgccccct 61920gtctgtgctg gagaattcag agcccactga ctcatctttc
tttgtggcct gggagagttg 61980tggagaacat gccgtacctt cgcggtgccg cacggatctt
cctgctccct ccctcgggag 62040tctcgcaggg accccatctc gttttaatgt tttgtcaata
cggcacccac gagaacgttg 62100cagggaagac accactgtgg ccgtaaacca cagaaactag
agctgaagtg gccccaggtg 62160gcctccagtc aagtggtatc caaattcttc accctgaggc
cctttattta ttattattat 62220tattagagac ggagtttcgc tcttgttacc caggctggag
tgcaatggtg tgatatcagc 62280tcaccgcaac ctccgcctcc cgggttcaag caattctccg
gcctcagcct cccaagtagc 62340tgggattaca ggtgggcgcc accacgcctg gctaattttt
tgtattttta gagatgggga 62400ttctctatgt tggtcaggct ggtctcgaac tcccaacctc
aggtgagctg ctggccttgg 62460cctcccaaag tgctgggatt acaggcgtgc accaccacac
ccatccctat cttattcttt 62520ttctctcacc agggacccca aatttggaag aaccataatc
atgtttattg acatcatgtt 62580aaattaaggt tcccacgttt attaataaaa gaaatatatc
attagcctgg ccttttaaat 62640ttttcttaat ttaatttttt ttttttttga ggcagggtct
cactctgtca cccaggctgg 62700agtgcaatgg taccatcatg gctcaccaca gccccccgct
cctaggctca agcaatcctc 62760ttgcctcagc ctcctgagta tctggggatt ataggtgcac
accatcacac tcagccaatt 62820aaaaaaaaat ttctagtaga gatggggtct caccaagttg
tccaggctgg tctcacactt 62880ctgagctcaa gtaatcctcc tgctttggcc tcccaaagtg
ctcggattac aggggtaagc 62940taccacattc agcctttatt tttattttta atggaggtaa
aagccacata acataaaatt 63000taccctttca actacttctt ttttttagat ggaggcttgc
tctgttgccc aggctggagt 63060gcagtggcac aatctcagct cacttcaacc tctacctccc
gggttcaagt gattcccctg 63120cctcagcctc ccaagtagct gggatcacag gcacccgcca
ccacacctgg caattttttt 63180gtattttagt agagacgggg tttcactgtg ttggccaaga
cggtgtcgat ctcctgacct 63240cgtgatccgc ctgcctcggc ctcccaaagt gctgggatta
caggcatgag ccaccgcgcc 63300cggccccttt aaagtatttt taaggataca cttcagcagt
gttcatcata tccgcattgt 63360tgtataacag atgtttacaa cttcttcatc ttacaaaaca
gaaactgtgt ccacatcaaa 63420ccagggtgcc ccattccccc ggcccctggc acccaccatt
ctactgtctg tctctatgaa 63480ttccactctt ccagagacct cataggagtg ggatcacaca
gcactttttt gtctggctta 63540tcttgttaac aacaggtgag tccatgtggt agcctgtctc
atcattcctt cctttttagg 63600gctgattcat atttcattat atggatgaac cacattttct
ttttccagtc atgctgtaac 63660aggatgagtc acagtcaaaa ctcctcagac accagattaa
agaaggaaga ggttttttta 63720tttggccggg agattcggca gactcgtgtc ttaagagccg
agctccccga aaaagaaatt 63780cctagccctt ttaagggcta agaactctaa ggggtctatg
tgaaagagtc ataatagatc 63840aagtaagtgt gaggaacgtg agtgggggct acatacatca
gctaagagaa caaaaagttt 63900ttattttttt attttttttg agacggaatc tcgctctgtg
gcccaggctg gagtgcagtg 63960gtgtgatctc agctcacttc aagctccgcc tcccgggttc
acagcattct cctgcctcag 64020cctccccagt agctgggact acaggcgccc gccaccgcgc
ccggctaatt ttttgtattt 64080ttagtagaca cggggtttca tcatgttaac caggatggtc
tcgatctcct gaccttgtga 64140tccacccgcc tcggcctccc aaagtgctgg gattagaggc
tggagccacc gtgcccggcc 64200tgcacccagc taattttttg tatttttagt agagatgggg
tttcaccgtg ttagccagga 64260tggtctccat ctcctgacct catgatccgc ccacctcggc
ctcccaaagt cctgggatta 64320caggcgtgag ccaccgcgcc cggccagaac aaaaagtttt
acagtgcttt ctcatacaat 64380gtctggaatt tacagatagc accagtagtt ttggtcagcg
gttaatacta ttattatttt 64440aatcaccagg gccaggtggt ggcaccaagg tcgtctagct
atttatctta cttttgtttc 64500tttccaactt tttgctttct ctcttttctc ttgtcttata
aactagggaa aaggggaggt 64560tggggagaaa ctggaaagga caacaggaga agtggtggtg
tcataacata atgcgatcat 64620gggcaccggg ctgcttccat cttttggcta ttgtgaatac
tgctgtaacg accacggttg 64680tgcaataatc ccttccagac tctgctttca atctttttgg
atttagtcgg agaagtaatg 64740tgattgctgg ttcataggtg gttccatttc tggttattta
tttatttttt aagagacaga 64800gttttatatg ttgcccaggc tggccttgaa ctcctgggct
tcagtgatcc ccttccctca 64860gcctcccaag tagccggtag tgcagctgca catcaccaca
cccaagtgat ttttagttgt 64920tatttttctg gttttgtttt tgcggagatg gagtttcact
gtgccgccca gggtggagtg 64980cggtggcata atcggctcac tgcagcctcc acctcctggt
tcaggcgctt ctcctgcctt 65040agcctcccga gtagctggga ctataggcat ctgtcaccac
actcagctaa ttattttgtg 65100tttgcttccc cccaccccgc ccccccgaga tggagtcttc
ctttgtcacc caggctggag 65160tgcagtggcg cgatctcggc tcaatgcaac ctctgcctcc
ggggttcaag caattctcct 65220gcctcagcct cccgggtagc tgggattcct ggcacccaca
accacgcccg gctaattttt 65280tatttttagt agagacggag tttcaccatg ttggccaggc
tggtctcgaa ctcctgactt 65340tgtgatccac ctgcctcggg ctcccaaagt gctgggatga
caggtgtgag ccactgtgcc 65400cagcctgata tttagtgctt ttttgaggag gctccatagt
gttttccacg gtggccacac 65460cattttctag tcctacaggc aatccacgag ggctccaatt
tccacacatc cttgttaaca 65520ctatttttgt ttcactgtag catttcatgg atgtgaggtg
ctatcactgt ggttttgatg 65580tgtatttctc taatgattac tgatgttgag gatccttcca
tgtttgtttg ctacttgtat 65640atcttttctg gagaaatatc tattcaggtc gtttgctcat
ttttcaatca gttaacttgt 65700ttttcaattg ttcagttgca ggagctcttt atatgtgctg
gacgaatatc cgacgtacca 65760gacatataat ctgcagttat ttcctcttat tccatgtctt
gcctttccac tgttgtttcc 65820tgtgcagaaa tgtttaacct cgaagttgga ccatttgtct
atttgtgctt ttgttgcctg 65880tgcttatctg ggctttggat aggccagagg taaacggcag
gtgttactgc accaagttca 65940taaaatcgag cccaaaacaa aggagtcgac acagtaatta
gctggtgtgt cgccttggcg 66000agaatatata tgacttttgc tgagaatttt cattaatgtt
tattttctat ttttattttt 66060tgagatggag tctcgctctg tcgcccaggc cggagtgcag
tggtgcaatc tcagctcact 66120gcaagctcca cctcccgggc tcacgctgtt ctcctgcctc
agcctcccga gtagctggga 66180ctacaggcgc ccgccaccgc gcccggagaa ttttttgtat
ttttagtaga gatggggttt 66240cactgtgttg gccaggatgg tcttgatctc ctgacctcgt
gatccacctg ccttggcctc 66300ccaaagtgct gggattacag gcgtgagcca ccgcgcccgg
ccattaatgt ttattttgac 66360gcaacttcac agttacatta aggcaacaat atggcacaaa
gaattccttc gtatcaggca 66420ttcacattcc ccaaacgctg gcggtctaca ccggcttcat
cctggatcag aaccaagtgg 66480agggactgct gtttctgtgg gctggtttcc tgggggctgc
cataaccagt gaccagaaac 66540cgggtgggta cgtcaacagg aatttatcat ctcccagtct
cggatgtcga tgttgaagcc 66600ctaaccccca ctgcctcaga acgtgagtgt atttggcctc
atagtattag aacgaggctg 66660tcagggtggg ccctaaagca acctgctgtt ctcatgagag
gaagtgtgga cacacacaga 66720agagacgata gggatacttg tgcacagtga aaagacccta
tgagcgtaca ccagacggcg 66780tccgcaagcc gaggagagga gaaaccagcc ctgctgacaa
caccttgctc tcggacctca 66840gcctccaggt ctgtgggaag ataattttca gtgaagccct
ccagtcttgg taccttatgg 66900cggccctgaa cactcataca gacgggtaca tttactgtcc
ctgttcttct gccgaggaaa 66960tggaggcaca gagacgttta gtgagcttga cccatgcggg
agggccagga gcggtcaagg 67020ttggattgga acaaaccacc ctttttgcag cactcacgtt
cttaggcacg acgcctgctt 67080ccttaggtgc tctgcaaaga gaatacggca gagtgcaccc
cgaacacgca acggtacagt 67140cacaaagatg acactggctc caagtgtctt cagcaaaatg
ggaacgtgtc agaagagtag 67200gggggtcgct gcgggaacag ggttggccca aggcagccgc
cggtcccgag cagcatgcgc 67260gatgcgggct gggcaggacc ccgtggcccc tccgccgccc
tctcagtccg cgcgagggcc 67320ccactcgggg ctcggccggg ctccgggaac gcggtctgcg
gtccaggggc cgcgagcctc 67380cgccgctcct cggcctcgtg ggcccgggcg ctgggtgggg
ccgcgggtgg gcgtcagggg 67440ccaggctggg cgccgaggtc tgcaaagggg cggagaagac
ggccttgggc tccgcgcaga 67500acctgcgagt gggcggcggt gcacctccca cccgggtcac
ctcggtgcca cccatgcctg 67560cctcagtgca ggcggaccca cggccctcca cgccctccct
cgctcgcgtg ctgcccggct 67620ggccgctgtt cgcatcctct cgctaactcc gtggggtccc
gcccattcgg gcgactgccc 67680cggctgcagc ccacccgcta atctcggcta tcttccctca
ctcagttctt cgcctccacc 67740agcttcggct cttttcgtca cccctcttta ctccccgttc
ctctccgtca ctttccgtca 67800tctccgaata ggctcggccg gctgcatctc accatttcgc
tttcctcttt gtcgccctct 67860gataaatttc gtgactcttc gtcactgtcc gtcagtcccc
gtcactttcc gtcaattctc 67920gccactttcc gtcgctctcc gccgcccttc agctccgctc
ggctcttctc cgtcagacat 67980cgtctacttt cgtcactctc cgtcaccctc cgtcactctc
cgtctgctcc ctaccccgca 68040ctccgggtgg agaaagcctc agggactttt cctgccctta
gcccttttcc gtccctctcc 68100gatcctgctg tctgtcagtc cctggttatt tctggtctgc
tcgtgactct gtcctcctcc 68160cttcactcct gggagggtgg cctggtccct cctgagaggc
ctctccccac tacccggcct 68220gaatgatggt ggtgagcggg aggtctcgag gtgatcccga
gggaaggagc gggggtctga 68280gggtggtccc gagagggacc cgaggggtgg agcgggggga
gggtctggag atggccccga 68340ggaggtcccg ataggaggag cggcagtctg ggggtggtgc
cgagggaaga agccgtctgg 68400tgtggtctgg aaaatgggag cagggggtct ggggtggtcc
cgaggggagg agcgggggtc 68460tggggtggtc ccgaggggag gagcgggggt ctgaggtggt
cccgagggga ggagctgggg 68520gttctgggtg tggtcccgtg ggtaggaggg ggggtctggg
gatggtccta agaggaggag 68580cagggggtct gggggtggtc ccgaggggag gagcgggggt
ctggggtggt cccgagggga 68640ggagcggggg tctggggtgg tcccgagggg aggagcgggg
gtctggggtg gtcccgaggg 68700gaggagctgg gggttctggg tgtggtcccg tgggtaggag
ggggggtctg gggatggtcc 68760taagaggagg agcagggggt ctgggggtgg tcccgagggg
aggagcgggg gtctggggtg 68820gtcccgaggg gaggagcggg ggtctggggt ggtcccgagg
ggaggagcgg gggtctgggg 68880tggtcccgag gggaggagct gggggttctg ggtgtggtcc
cgtgggtagg agggggggtc 68940tgggtgtggt cccgagggga ggagctgggg gttctgggtg
tggtcccgtg ggtaggaggg 69000ggggtctggg gatggtccta agaggaggag cagggggtct
gggggtggtc ccgaggggag 69060gagcgggggt ctggggtggt cccgagggga ggagcggggg
tctggggtgg tcccgagggg 69120aggagctggg ggttctgggt gtggtcccgt gggtaggagg
gggggtctgg gtgtggtccc 69180gaggggagga gctgggggtt ctgggtgtgg tcccgtgggt
aggagggggg gtctggggat 69240ggtcctaaga ggaggagcag ggggtctggg ggtggtcccg
aggggaggag cgggggtctg 69300gggtggtccc gaggggagga gcgggggtct gaggtggtcc
cgaggggagg agctgggggt 69360tctgggtgtg gtcccgtggg taggaggggg ggtctgggga
tggtcctaag aggaggagca 69420gggggtctgg gggtggtccc gaggggagga gcgggggtct
ggggtggtcc cgaggggagg 69480agcgggggtc tggggtggtc ccgaggggag gagcaggggg
tctgggggtg gtcccgaggg 69540gaggagcggg ggtctggggt ggtcccgagg ggaggagctg
ggggttctgg gtgtggtccc 69600gtgggtagaa gggggggtct ggggatggtc ctaagaggag
gagcaggggg tctgggggtg 69660gtcccgaggg gaggagcggg ggtctggggt ggtcccgagg
ggaggagctg ggggttctgg 69720gtgtggtccc gtgggtagga ggggggggtc tggggatggc
cctaagagga ggagcggggg 69780tctgcgtgtg gttttcaggg gtggagcatg gggtctccct
gtggttcgga gggtggagca 69840gggggtctgg ggttggtact tttgggcggg acagcgctat
ttctcttttt ggtccggttc 69900ccatctgctg atctgggggt ccttgtgatc ctgacaggtg
gggccgaatg ggagggtcaa 69960ggtgagggga aggaaggagt ggcagcctgg tcccaaggga
gcaggaaagg gtttgtggtt 70020cagttctgat gtgtgaccca tccataggag aatggacacc
tcagactctc tcaatcctgg 70080ccagtggcag gtcccagtag ctgccttccc tggctgtcct
tgaggctcac tggaggatac 70140ttctttttca ttctggcaaa ttttaaaaaa ttcttctata
gatctcagtg agttcaaagc 70200tgcctgtgtg caggcataga tccgttcttt gctgagcttc
cactctagtc ggctgaaagg 70260aaagggtaat atagctggaa aaggtatcct ggggtgatta
gaggattcta catttcatct 70320tagaaaggga tattgacagg agaccagaac ttccagatcc
tcttgaattt caagaactac 70380ttccaagcct ggacaatatc gggaggcctc atctctacaa
aataaaaatt aagaaattcg 70440ccacgtgcga tggcacactc ctgtagtccc acctactctg
gaggctgagg cgggaagatc 70500gcttgagctt gggagtccga ggctgcagtc agctgtgatc
atgccactgc actccagcct 70560gggtgacaga gcaagaccct gaaaaaaaaa aagggaggga
gggaaggagg gagggaggga 70620ggaaggaagg aatgaaggaa ggaaggaaat ggcttaagct
cagagagctg tgtgtggccc 70680ccagctccca acccctacca aagggcctgc aaacccacgg
aggggcaggt tgtcttgagc 70740tggagctacg gggacggggg gacctgaact gtcggggtta
gggttagggt taggctttga 70800gatttcgggt tacagaatat agatgggttt ggtcctggga
aaattccagg tctgggtttt 70860gcagttgggg gttggtctca ggtgagatgc ggcaggttta
cagtgtttgc aaggtatgta 70920cagatttata tggtgctatt gcttgaatgt gttctccaga
tttcatgtgt tggcaatttt 70980ttttcttttc tttttgacat ggtgtcttgc tctgtcatct
atcacccagg ctggagtgca 71040atcgtgggat ctcggctcgc tgcaacctct gcctcccagg
ttcgagcgat tctcacacct 71100cagcctcctg gtagctggca ttgtggcagg acaagccgca
gacaaaattc ctcagacact 71160gggttaaaga aggaagggct ttactctgcc aggagcatcg
gcacacttgc gcctgaagag 71220ccaagctccc cgaaaacgaa attcctagcc cttttaaggg
tttacaactc taaggggttt 71280acgtgaaagg gttgtgatag atcgaggaag cgtggggaac
gtgactgggg gctacacgca 71340tcagataaca gaacagaaag ttttgcaggg cttcctcata
cagtgtctgg aatttacaga 71400taacacaagt agtttaggtc aggggttaat attattatta
ttattatttt aaccaccagg 71460gtcgggtggt gctgccaagg tcatctagct atttatctta
cttctgtttt tttttttttt 71520taagcttttt gctttctccc tttttccctg ttttataaac
taaggaagcg gtgtggggaa 71580gggaagggca gcaggaggag tggtggtctc cttccttagg
attacaagca ccgggcctca 71640ttcctggcta acgttttttg tttttttttt gtatttgtat
tagagatggg gtttcaccat 71700gttggccagg ctggtcttga actcctgacc tcagctgatc
gcctgccttg gcctctgaaa 71760gtgctgggat taaaagcaca aggcagctgg gcgcggtggc
tcaggcctgc aatcctagca 71820ctttgggaga ccgagatggg tggatcacga ggtcaggaga
tcgagaccat cctggctaac 71880atggtgaaac cctgtctcta caaagaaata caaaaaaaaa
aaaaaaatta gctgggcgtg 71940gtggcgggcg cctgtagtcc cagctactca ggaggctgag
gcaggagaat ggcgtgaacc 72000cgggaggcag agcttgcagt gagccgagat agcgccactg
cactccagcc tgggcgacag 72060agcgagactc cgtctcaaaa aaaaaaaaaa aaaaagcaca
aggcatcgcg cccagccatg 72120tgttggcaat ttaatccccg aattcatgtc ctgattggag
atatggcctt tgggaggcaa 72180ttaggattag ataatgttat taggttgggt ccccagtcat
gggactcgtg gctttataag 72240atgaggaaga gagactggag cggacacgca gtcttgccct
ctcctccctc gcccgcacac 72300tcttgctctc ccctcccctg ccatgtgcag ccctccactg
ggctgtgatg ctctaggcct 72360ccccagccac cagaacttgc cctcccctcc tcggccatga
gtggacacag actcccgccc 72420tcccgccatg tgccgccctc cactgggctg ggatgctctg
ggccatgtgc tgcctggggt 72480ccaggggccg ttagtctccg ccgctcctcg gcctcgtggg
cccgggcgct gggtggggcc 72540gcgggtgggc gtcaggggcc aggctgggcg ccgaggtctg
caaaggggcg gagaagacgg 72600ccttgggctc cgcgcagaac ctgcgagtgg gcggcggtgc
acctcccgcc cgggtcacct 72660cggtgccacc catgcctgcc tcagtgcagg cggacccacg
gccctccacg ccctccctcg 72720ctcgcgtgct gcccggctgg ccgctgttcg catcctctcg
ctaactccgt ggggtcccgc 72780ccattcgggc gactgccccg gctgcagccc acccgctaat
ctcggctatc ttccctcact 72840cagttcttcg cctccaccag cttcggctct tttcgtcacc
cctctttact cctcgttcct 72900ctccgtcact ttccgtcatc tccgattagg ctcggccggc
tgcatctcac catttcgctt 72960tcctctttgt cgccctctga taaatttcgt gactcttcgt
cactgtccgt cagtccccgt 73020cactttccgt caattctcgc cactttccgt cactctccgc
cgcccttcag ctccgctcgg 73080ctcttctccg tcagacatcg tctactttcg tcactctccg
tcaccctccg tcactctccg 73140tctgctccct accccgcact ccgggtggag aaagcctcag
ggacttttcc tgcccttagc 73200ccttttctgt ccctctccga tcctgctgtc tgtcagtccc
tggttatttc tggtctgctc 73260gtgactctgt cctcctccct tcactcctgg gagagtggcc
tggtccctcc tgagaggcct 73320ctccccacta cccggcctga atgatggtgg tgagcgggag
gtctcgaggt gatcccaagg 73380gaaggagcgg gggtctgggg gtggcggcga gggggttccg
aggggaggag cgagcgtctg 73440gggatggttc cgagagggac ccgaggggtg taccgggggt
agggtctgga ggtggcccga 73500agggggtccc gacaggagga gcggcagtct gggggtggcg
ctgagggaag gagcagtcgc 73560gtggtccgga ggacaggagc agggagtctg ggggtggttt
cgtggggagg agcagggggt 73620ctgggggtgg tcccgagggg aggagcgggg gatggcgccg
agggaaggag ctgtctggtg 73680tggtccggag gacaggaaca gtggatctgg gggtggtcct
gatgggagga gcgggggtct 73740gggggtggtc ccgaggggaa gcgtgggggt ctgtgggtgg
tccttagggg aggagcgggg 73800gtctgggggt ggtcctgtgg ggaggagcag ggggttctgg
gggcggtcct gatgggagga 73860gcgggggtct gggggtgatc ccgaggggaa gcgtgggggt
ctgtgggtgg tccttagggg 73920aggagcgggg gtctggggat gatcctgagg ggaggagctg
gggtctgggg atggcgccga 73980gggaaggagc tgtccggtgt ggtccggagg acaggaacag
tggatctggg ggcggtcccg 74040tggggaggag cagggagtct gggggtggtt ttcagggatg
gagcatgggg cctccctgtg 74100gtccagaggg tggagcaggg agtctggggg tggtacttat
gggcgggaca gcactatttc 74160tctttttggt ccggttccca tctgctgatc tgggggtcct
tgtgatcctg acaggtgggg 74220cagaatggga gggtcaaggt gaggggaagg gatattgaca
ggaggtcaga acttcaagat 74280cctcttgaat ttcaagaact acttccaagc ctggacaata
tcgagaggcc tcatctctac 74340aaaataaaaa ttaagaaatt cgctgggtgc aatggcacac
tcctgtagtc ccacctactc 74400tggaggctga ggagggaaga taacttgagc ctgggagtcc
gaggctgcag tcagctgtga 74460tcatgccact gcactccagc ctgggtgaca gagcaagacc
ctgaaaaaaa aaagggaggg 74520agggaaggag ggagggaggg aggaaggaag ggaagggagg
gaggaaggaa ggaatgaagg 74580aagaaaatgg cttaagctca gagagctgta tgtggccccc
agctcccacc cccaccagag 74640ggcctgcaaa cccacggagg ggcaggttgt cttgagctgg
aaccacaggg gcggggggac 74700ctcaactgta ggggttaggg ttagggttag gctttgaggt
ttcgggttac agaatataga 74760tgggtttggt cctgggaaaa ttccaggttg agttttgtag
ttgggggttg gtctcaggtg 74820agatacggca ggtttacttg ggcctgaaga gccgagctcc
ccgaaaacga aattcctggc 74880ccttttaagg gtttacgact ctaaggggtt cacgtgaaag
ggtcgtgata gatcgaggaa 74940gcatcggaac gtgactgggg gctacacgca tcagataaca
gaacagaaag ttttgcaggg 75000cttcctcata cagtgtctgg aatttacaga taacacaagt
agtttaggtc aggggttaat 75060attattatta ttattatttt aaccaccagt gccgggtggt
gctgccaagg tcgtctagct 75120atttatctta cttctgtttt ttttatcttt ttgctttctc
cctttttccc tgtttcataa 75180actagagaag ggggtgtggg gaagggaagg gcagcagaag
tggcggtctc ctcccttagg 75240attacaggca ccctgcgtta acctcaaaat tgtctcagtc
ccaaagaagg ggctagattt 75300tcttttatac ttttgtttag aaaggggagt ggcggtctag
ttaaaagaat tttacataag 75360taaatcaggc aaaatgttaa aaggataaat ggttacagga
aagtaaacag ttccaggtgc 75420aggtgcttta agactattac aaggtgatag acgcgggtaa
ttgggcgtta tcaatcggac 75480gaattcctgg ggactgcgga tgtagctcgc cacagtaggt
tgtcagttaa ttgcattctc 75540ggatgtcctg ggagtcagct tgcacgagtt aagtctttga
ggaaggggct gccagtgaaa 75600gagccaagat ggagtctgtc cggttctctc agttaaggga
gagtcctttc aggtggaaag 75660aaggctaggt gattgaagga aagggagagt ctaaaaacag
ggttagcaaa aatgaggttg 75720ggcattacag ttgtaccctc catcgcctct tccaatctca
agcaattcca taacttggaa 75780aacctcaggc aaggacttcc tggaatatgt ccactgtaac
gaccaggttt tccagtgtgt 75840tatctacacc ctgtaacgct gttaggtaca taatgtttca
gcaatctttg ttcttcacca 75900gcactctgag tacatgaaaa aggccaagat gcttcttcag
ggatgaattt tgctactttt 75960taaaggagac ttaagaggca cttttggcac tctaagtctt
tcttcaaatg atgaaatttg 76020ttacctattt aactcattgc tgtgacgcgt tttccaattc
tatgttccct tggtttttgt 76080tgtatttttt tctgcatgaa ctctacatca tttactcact
ctgaacgaca gaataaaaga 76140aattggccac catatcatac tcggaaggac aatcatggcc
atgagacaca aaggactccc 76200agccctgggc ccaggccccc ctcacgcatg cagccatcgc
ggcactgtgc ctgagtgggc 76260catatgcatg gtggggaccc gatgctggga gacacagctc
agggcacagg ggccccaaga 76320agccatagct ggggaaagct cattcccgac agggctcagc
tccaacctga aactagagtc 76380ccaccctggg gtttccatgg tggtggtaaa ccaaccacag
attttgggga tatgactgct 76440ccctttgcca cgatagcttc ttccacgtgc ccctggcctg
atgaccagac cactagagag 76500gggaggcccg agtcccaggg atgggtgggt tgcaggcaga
gctggggctg gatggacggt 76560gagtggtgag agctcaaggt gcagaagggg ctcctgtcgg
ggactgggtt aacagggacc 76620gggacaaata gacggggact cccgagatga gaaagacctt
ttcgtacaaa gtgtttgcat 76680cagtacctca caatgaaaag aataagataa ataacagtac
aaaaaagcaa tcaccagatc 76740agctcaaggc actctttgaa gtcccccctg tgtagggaag
ttggaagaca tatctgtgtg 76800gcccatagag agtagatccc aaagacagaa ggcccaagtc
cctaaatccc cacaggggaa 76860ctgtgttaca gaccaggagc tcatgtacag ggctgtccca
gggcccctaa attccagaag 76920ggaactgggt tagagwccag gggctsatgy aacgggctgt
ccctggtccc ctaaatcccc 76980acaggggaac tgggttagag atgaggagct cattttccgg
gctgtccagg tcccctaaat 77040cccagatggg aactgggtta tcraccaggt gctcttctag
gggttgtctc agggtcctag 77100tgtgtctgga attggtgggt tcttggtctc actgacttca
agaatgaaga cgcggaacct 77160cgcggtgagt gttacagttc ttaaaggtgg cgcgtccgga
gtttgtttct tctgatgttc 77220agatgtgttc tgagtttctt ctttctggtg gggttgtggt
ctcactggct caggagtgaa 77280gctgcagacc tttgcggtga gtgtcacagc tcataaaggc
agtgtggacc caaagagtga 77340gcartagcaa gatttattgc aaagagtgaa agaacgaagc
ttccacagta tggaaaggga 77400ccccattggg ttgccactgc tggctcaggc agtctgcttt
tattctctaa tctgctccca 77460cccacatcct gctgataggt ccactttcag agggttaggg
ttagggttag ggttagggtt 77520agggttaggg ttagggttag ggttagggtt agggttaggg
ttagggttag ggttagggtc 77580ctttagagtc tgcattaggc ctatgtctca ttgaggacag
ttagagagca gactgtgcta 77640cctttagagt ctgcatttgg cctaggtctc attgagtaca
gaaagagacc agagtgtgca 77700acctttagag tctgcattgg gcctgggtct cattgaggac
agatagagag gagactgtag 77760aacctttata gtctgcattg ggcctaggtc tcattgaggt
cagataggga gcagactggg 77820caagctttag agtctgcact tggcctaggt ctcattgagg
acagatagag aacagactgt 77880gcaaccttta gagtctgcat tgggcctagg tctcattgag
ggcagttaga gagcagactg 77940tgcaaccttt agagtctgca ttgggcctag gtctcattga
gagcagatag agagcacact 78000gtgcaacctc tagagtcggc attgggccta ggtctcattg
aggacagata gagaccagac 78060tgtgcaaact ttagagtctg cattgggcct aggtctcatt
gaggacagat acagggcaga 78120ctgtgcaacc tttagagtct gcattgggcc taggtctcat
tgaggtcaga tagagagcag 78180actgtgcaac ctttagagtc tgcactgggc ctaggtctca
ttgagggcag atagagacca 78240tactgtgcaa cctttagagt ctgcattggg tctaggtctc
actgaggaga gatagagagc 78300agactttgca aactttagag tctgcattag gtctaggtct
cactgaggac tgatagagag 78360cagattatgc aacctttaga gtctgcactg gccctaggtc
tcattgagga cagatagaga 78420gcagactgcg caaactttag agtctgcatt gggcctaggt
ctcattgagg acagatagag 78480agcacactgt gtaaccttta gagtctgcat agggcctcgg
tctcattgag gaccgataga 78540gagcagactg tgccaccttt agagtctgca ttgggcctgg
gtctcattga ggagaaatag 78600agagcagact gtgcaacctt tagagtctgc attgggccta
ggtctcattg aggacagatg 78660gagagcagac tgtgcaacct ttagagtctg cattgggcct
aggtctcatt gagggcacat 78720agagagcaga ctgtgcaacc tttagagtct gcattgggcc
taggtctcat tgagagaaga 78780tagagagcat acagtgcaac ctttagagtc ggcattgggc
ctaggtctca ttgagggcac 78840atagagagca gactgtgcaa cctttagagt ctgcattggg
cctaggtctc attgagagaa 78900gatagagagc atacagtgca acctttagag tcggcattgg
gcctaggtct cattgaggac 78960agatagagac cagactgtga aacctttaga gtctgcattg
ggcctaggtc tcattgagga 79020cagatagaga gcagagtagg caaccattag agtcggcact
ggtcctaggt ctcattgagg 79080acagatatag agcagactgt gcaaccttta gagtctgcat
tgggcctggg tctcattgag 79140gacagataga gagcagactg tgcaaccttt agaggctgca
ctgggcctag gtctcattga 79200ggacagatag agggcagact gtgcaacctt tagagtctgc
attgggccta ggtctcattg 79260aggaccgata gagagcagac tgtgcaacct ttagagtctg
cactgggcct aggtctcatt 79320gagggcagat agagaccata ctgtgcaacc tttagagtct
gcattgggcc taggtctcac 79380tgaggagaga tagagagcac actgtgtaac ctttagagac
tgcatagggc ctcggtctca 79440ttgaggaccg atagagagca gactgtgcca cctttagagt
ctgcattggg cctgggtctc 79500attgaggaca aatagagagc agactgtgca acctttagag
tctgcattgg gcctaggtct 79560cattgaggac agatggagag cagactgtgc aacctataga
gtctgcattg ggcctaggtc 79620tcattgagga cagatggaaa gcagactgtg caacctttag
agtctgcatt ggacctaggt 79680ctcattgagg acagatagag agcagactat gcaaacttta
gaggctggac tgagcctagg 79740tctcattgag gacagataga gagcagactg tgcaaccttt
acagtctgca ttgggcctgg 79800gcctcattca ggacagatag agaccagact gtgcaacctt
tagagtctgc attgggccta 79860ggtctcattg agagtagata gagagcagac tgtgcaacct
ttagagtcta cattgggcct 79920aggtctcatt gagggcagat agagagcaga ctgtgcaacc
tttagagtct gcacttggcc 79980taggtctcat tgaggacaca tagagagcag actgtgcaac
ctttagagtc tgcattgggc 80040ctaggtctca ttgagggcag atagagagca gactgtgcaa
actttagagt ttgcattggg 80100cctaggtctc attgaggaga gatagagagc agactgtgca
acctttagag tctgcattgg 80160gcctaggtct cattgaggac agatggagag cacactgtgc
aacctttaga gtccgcattg 80220ggcctaggtc tcattgagga cagatagaga ccagactgtg
caacctttag agtttgcatt 80280gggcctaggt ctcattgagg gcagatagag agcagactgt
gcaaccttta gagtctgcat 80340tgggcctagg tctcattgag gaccgataga gagcagactg
tgcaaccttt agactctgca 80400ttgggcctgg gtctcattga ggacaaatag agaacagact
gtgcaacctt tagagtctgc 80460attgggccta ggtatcagtg aggacagata gagaggagac
tgtgcaacct ttagagtctg 80520cactgggcct aggtctcttt gaggacagac agagagcaga
ctgtgcaaac tttagagtct 80580gcactgggcc taggtgtcat tgaggacaga tagagaccag
actgtgcaac ctttagagtc 80640tgcattgggc ctaggtctcc ttgaggtcag atagacagca
gaatctgcaa cctttagagt 80700ctgcattggg cctaggtcta attgcggaca gatagacagc
agactgtgca acgtttagag 80760tctgcattgg gcctaggtct aattgcggac agatagagag
cagactatgc aacgtttaga 80820gtctgcattg ggcctgggtc tcattgagga cagatagaga
gcagactgtg caacctttag 80880agtctctatt gggcctaggt ctcattgagg acagataggg
agaggactgt gcaaccttta 80940gagtctgcat tgggcctagg tctcattgag ggcagataga
gagcaggctc gggaaccctt 81000agagtctgca ttgggcctag atctcattga ggacagatag
agagcatact atgcaacctt 81060tagagtctgc actgggccta ggtctcattg aggacacata
gagagcagac tgtgcaacct 81120ttagagtctg cattgggcct atgtctcatt gaggacagtt
agagagcagg ctgtgcaacc 81180tttacagtct gcatttggcc taggtctcat tgaggacaga
aagagaccag agtgcgcaaa 81240ctttagagtc tgcattgggc ctaggtctca ttgaggacag
atagagagca gactgtagaa 81300cctttatagt ctgcattggg cctaggtctc attgaggtca
gatagagagc agactgtgca 81360agctttagag tctgcacttg gcctaggtct cattgaggac
agatagagaa cagactgtgc 81420aacctttaga gtctgcattg ggcctaggtc tcattgaggg
cagttagaga gcagactgtg 81480caacctttag agtctgcatt gggcctaggt ctcattgaga
gcagatagag agcacactgt 81540gcaacctcta gagtcggcat tgggcctagg tctcattgag
gacagataga gaccagactg 81600tgcaaacttt agagtctgca ttgggcctag gtctcattga
ggacagatag agggcagact 81660gtgcaacctt tagagtctgc attgagccta ggtctcattg
aggacagata gagagcagac 81720tgtgcaacct ttcgagtctg cactgggcct aggtctcatt
gagggcatat agagaccata 81780ctgtgcaaac tttagagtct gcattgggtc taggtctcac
tgaggagaga tagagagcag 81840actttgcaaa ctttagagtc tgcattaggt ctaggtctca
ctgaggactg atagagagca 81900gactatgcaa ctttagagtc tgcactggcc ctaggtctca
ttgaggacag atagagagca 81960gactgcgcaa actttagagt ctgcattggg tctaggtctc
attgaggaca gatagagagc 82020acactgtgta acctttagag tctgcataga gcctcggtct
cattgaggac cgatagagag 82080cagactgtgc cacctttaga gtctgcattg ggcctgggtc
tcactgagga gaaatagaga 82140gcagactgtg caacctttag agtctgcatt gggcctaggt
ctcattgagg acagatggag 82200agcagactgt gcaaccttta gagtctgcat tgggcctagg
tctcattgag ggcagataga 82260gagcagactg tgcaaccttt agagtctgca ttgggcctag
gtctcattga gagcagatag 82320agagcatact gtgcaacctt tagagtcggc attgggccta
ggtctcattg aggacagata 82380gagaccagac tgtgcaacct ttagagtctg cattgggcct
aggtctcatt gaggacagat 82440agagagcaga ctatgcaacc attagagtcg acactggtcc
taggtctcat tgaggacaga 82500tatagagcag actgtgcaac ctttagagtc tgcattgtgc
ctgggtctca ttgaggacag 82560atagagagca gactaggcaa ccattagagt cgacactggt
cctaggtcta attgaggaca 82620gatatagtgc agactgtgca acctttagag tctgcattgg
gcctgggtct tattgaggac 82680agatagagac cagactgtgc aacctttaga gtctgcactg
ggcctaggtc tcattgagga 82740cagatagagg gcagactgtg caacctttag agtctgcatt
gggcctaggt ctcattgagg 82800acagatagag agcagactgt gcaaccttta gagtctgcac
tgggcctagg tctcattgag 82860ggcagataga gaccatactg tgcaaccttt agaatctgca
ttgggtctag gtctcactga 82920ggagagatag agagcagact ttgcaaactt tagagtctgc
attgggtcta ggtctcactg 82980aggactgata gagagcagac tatgcaacct ttagagtctg
cactggcact aggtctcatt 83040gaggacagat acagagcaga ctgcgcaaac tttagagtct
gcattgggcc taggtctcat 83100tgaggacaga tagagagcac actgtgtaac ctttagagtc
tgcatagggc ctcggtctct 83160atgaggaccg atagagagca gactgtgcaa cctttagagt
ctgcattggg cctgggtctc 83220attgaggaca aatagagagc agactgtgca acctttagag
tctgcattgg gcctaggtct 83280cattgaggag agatggagag cagactgtgc aacctttaga
gtctgcattg ggcctaggtc 83340tcattgagag cagatagaga gcagagtgtg caacctttag
agtctgcatt gggcctaggt 83400ctcattgagg gcagatagag accagactgt gcaaccttta
gagtctgcat tgggcctagg 83460tctcattgag gacagataga gggcagactg tgcaaccttt
agagtctgca ttgggcctag 83520gtctcattga ggacagatag agagcagact ttgcaaactt
tagagtctgc actgggccta 83580ggtctcattg agggcatata gagaccatac tgtgcaaact
ttagagtctg cattgggtct 83640aggtctcact gaggagagat agagagcaga ctttgcaaac
ttcagagtct gcattaggtc 83700taggtctcac tgaggactga tagagagcag actatgcaac
tttagagtct gcctggccct 83760aggtctcatt gaggacagat agagagcaga ctgcgcaaac
tttagagtct gcattgggcc 83820taggtctcac tgaggacaga tagagagcac actgtgtaac
ctttagagtt tgcatagggc 83880ctcggtctca ttgaggaccg atagagagca gactgtgcaa
cctttagagt ctgcattggg 83940cctgggtctc attgaggaaa aatagagagc agactgtgca
acctttagag tctgcattgg 84000gcctaggtct cattgagggc agatagagag cagactgtgc
aacctttaga gtctgcacta 84060gggctaggtc tcatcgagga cagatagaga gcagactgtg
caacatttag agtctgcatt 84120ggacctaggt ctcactgagg acagatagag agcagactat
gcaaacttta cagtctgcac 84180tgggcctagg tctcattgag gacagataga gagcagactg
tgcaaccttt acagtctgca 84240ttgggcctgg gtctcattca ggagagatag agaccagaat
gtgcaacctt tagagtttgc 84300attgggccta ggtctcttga gagcagatag agagcagact
gtgcaacctt tacagtctgc 84360attgggccta ggtctcattg agggccgata gagagcagac
tgtgcaaact ttagagtctg 84420cactgggcct aggtctgatt gaggacacat agagagcaga
ctgtgcaacc tttagagtct 84480gcatttggcc taggtctcat tgaggacaga tggagagcac
actgtgcaac ctttagagtc 84540cgcattgggc ctaggtctca ttgaggacag atagagacca
gactgtgcaa cctttagagt 84600ttgcattggg cctaggtctc attgagggca gatagagagc
agactgtgca acctttagag 84660tctgcattgg gcctaggtct cattgaggac cgatagagag
cagactgtgc aacctttaga 84720ctctgcattg ggcctgggtc tcattgagga caaatagaga
acagactgtg caacctttag 84780agtctgcatt gggcctaggt atcagtgagg acagatagag
aggagactgt gcaaccttta 84840gagtctgcac tgggcctagg tctctttgag gacagacaga
gagcagactg tgcaaacttt 84900agagtctgca ctgggcctag gtgtcattga ggacagatag
agaccagact gtgcaacctt 84960tagagtctgc attgggccta ggtctccttg aggtcagata
gacagcagaa tctgcaacct 85020ttagagtctg cattgggcct aggtctaatt gcggacagat
agacagcaga ctgtgcaacg 85080tttagagtct gcattgggcc taggtctaat tgcggacaga
tagagagcag actatgcaac 85140gtttagagtc tgcattgggc ctgggtctca ttgaggacag
atagagagca gactgtgcaa 85200cctttagagt ctctattggg cctaggtctc attgaggaca
gatagggaga ggactgtgca 85260acctttagag tctgcattgg gcctaggtct cattgagggc
agatagagag caggctcggg 85320aacccttaga gtctgcattg ggcctagatc tcattgagga
cagatagaga gcatactatg 85380caacctttag agtctgcact gggcctaggt ctcattgagg
acacatagag agcagactgt 85440gcaaccttta gagtctgcat tgggcctatg tctcattgag
gacagttaga gagcaggctg 85500tgcaaccttt acagtctgca tttggcctag gtctcattga
ggacagaaag agaccagagt 85560gcgcaaactt tagagtctgc attgggccta ggtctcattg
aggacagata gagagcagac 85620tgtagaacct ttatagtctg cattgggcct aggtctcatt
gaggtcagat agagagcaga 85680ctgtgcaagc tttagagtct gcacttggcc taggtctcat
tgaggacaga tagagaacag 85740actgtgcaac ctttagagtc tgcattgggc ctaggtctca
ttgagggcag ttagagagca 85800gactgtgcaa cctttagagt ctgcattggg cctaggtctc
attgagagca gatagagagc 85860acactgtgca acctctagag tcggcattgg gcctaggtct
cattgaggac agatagagac 85920cagactgtgc aaactttaga gtctgcattg ggcctaggtc
tcattgagga cagatagagg 85980gcagactgtg caacctttag agtctgcatt gagcctaggt
ctcattgagg acagatagag 86040agcagactgt gcaacctttc gagtctgcac tgggcctagg
tctcattgag ggcatataga 86100gaccatactg tgcaaacttt agagtctgca ttgggtctag
gtctcactga ggagagatag 86160agagcagact ttgcaaactt tagagtctgc attaggtcta
ggtctcactg aggactgata 86220gagagcagac tatgcaactt tagagtctgc actggcccta
ggtctcattg aggacagata 86280gagagcagac tgcgcaaact ttagagtctg cattgggtct
aggtctcatt gaggacagat 86340agagagcaca ctgtgtaacc tttagagtct gcatagagcc
tcggtctcat tgaggaccga 86400tagagagcag actgtgccac ctttagagtc tgcattgggc
ctgggtctca ctgaggagaa 86460atagagagca gactgtgcaa cctttagagt ctgcattggg
cctaggtctc attgaggaca 86520gatggagagc agactgtgca acctttagag tctgcattgg
gcctaggtct cattgagggc 86580agatagagag cagactgtgc aacctttaga gtctgcattg
ggcctaggtc tcattgagag 86640cagatagaga gcatactgtg caacctttag agtcggcatt
gggcctaggt ctcattgagg 86700acagatagag accagactgt gcaaccttta gagtctgcat
tgggcctagg tctcattgag 86760gacagataga gagcagacta tgcaaccatt agagtcgaca
ctggtcctag gtctcattga 86820ggacagatat agagcagact gtgcaacctt tagagtctgc
attgtgcctg ggtctcattg 86880aggacagata gagagcagac taggcaacca ttagagtcga
cactggtcct aggtctaatt 86940gaggacagat atagtgcaga ctgtgcaacc tttagagtct
gcattgggcc tgggtcttat 87000tgaggacaga tagagaccag actgtgcaac ctttagagtc
tgcactgggc ctaggtctca 87060ttgaggacag atagagggca gactgtgcaa cctttagagt
ctgcattggg cctaggtctc 87120attgaggaca gatagagagc agactgtgca acctttagag
tctgcactgg gcctaggtct 87180cattgagggc agatagagac catactgtgc aacctttaga
atctgcattg ggtctaggtc 87240tcactgagga gagatagaga gcagactttg caaactttag
agtctgcatt gggtctaggt 87300ctcactgagg actgatagag agcagactat gcaaccttta
gagtctgcac tggcactagg 87360tctcattgag gacagataca gagcagactg cgcaaacttt
agagtctgca ttgggcctag 87420gtctcattga ggacagatag agagcacact gtgtaacctt
tagagtctgc atagggcctc 87480ggtctctatg aggaccgata gagagcagac tgtgcaacct
ttagagtctg cattgggcct 87540gggtctcatt gaggacaaat agagagcaga ctgtgcaacc
tttagagtct gcattgggcc 87600taggtctcat tgaggagaga tggagagcag actgtgcaac
ctttagagtc tgcattgggc 87660ctaggtctca ttgagagcag atagagagca gagtgtgcaa
cctttagagt ctgcattggg 87720cctaggtctc attgagggca gatagagacc agactgtgca
acctttagag tctgcattgg 87780gcctaggtct cattgagagc agatagagag cagactgtgc
aacctttaga gtctgcattg 87840ggcctaggtc tcattgagga cagatggaga gcacactgtg
caacctttag agtccgcatt 87900gggcctaggt gtcattgagg acagatagag accagactgt
gcaaccttta gagtctgcat 87960tgggcctagg tctccttgag gtcagataga cagcagactc
tgcaaccttt agagtctgca 88020ttgggcctag gtctaattgc ggacagatag acagcagact
gtgcaacgtt tagagtctgc 88080attgggccta ggtctaattg cggacagata gagagcagac
tatgcaacgt ttagagtctg 88140cattgggcct gggtctcatt gaggacagat agagagcaga
ctgtgcaacc tttagagtct 88200ctattgggcc taggtctcat tgaggacaga tagggagcgg
actgtgcaac ctttagagtc 88260tgcattgggc ctaggtctca ttgacggcag acagagagca
ggctcggcaa cccttagagt 88320ctgcattggg cctagatctc attgaggaca gatagagagc
atactatgca acctttagag 88380tctgcactgg gcttagttct cattgaggaa acatagagag
cagactgtgc aacctttaga 88440gtctgcatta ggcctatgtc tcattgagga cagttagaga
gcagactgtg ctacctttag 88500agtctgcatt tggcctaggt ctcattgagt acagaaagag
accagagtgt gcaaccttta 88560gagtctgcat tgggcctggg tctcattgag gacagataga
gaggagactg tagaaccttt 88620atagtctgca ttgggcctag gtctcattga ggtcagatag
ggagcagact gggcaagctt 88680tagagtctgc acttggccta ggtctcattg aggacagata
gagaacagac tgtgcaacct 88740ttagagtctg cattgggcct aggtctcatt gagggcagtt
agagagcaga ctgtgcaacc 88800tttagagtct gcattgggcc taggtctcat tgagagcaga
tagagagcac actgtgcaac 88860ctctagagtc ggcattgggc ctaggtctca ttgaggacag
atagagacca gactgtgcaa 88920actttagagt ctgcattggg cctaggtctc attgaggaca
gatggagagc agactgtgca 88980acctttagag tctgcattgg gcctaggtct cattgagggc
acatagagag cagactgtgc 89040aacctttaga gtctgcattg ggcctaggtc tcattgagag
aagatagaga gcatacagtg 89100caacctttag agtcggcatt gggcctaggt ctcattgagg
gcacatagag agcagactgt 89160gcaaccttta gagtctgcat tgggcctagg tctcattgag
agaagataga gagcatacag 89220tgcaaccttt agagtcggca ttgggcctag gtctcattga
ggacagatag agaccagact 89280gtgaaacctt tagagtctgc attgggccta ggtctcattg
aggacagata gagagcagag 89340taggcaacca ttagagtcgg cactggtcct aggtctcatt
gaggacagat atagagcaga 89400ctgtgcaacc tttagagtct gcattgggcc tgggtctcat
tgaggacaga tagagagcag 89460actgtgcaac ctttagaggc tgcactgggc ctaggtctca
ttgaggacag atagagggca 89520gactgtgcaa cctttagagt ctgcattggg cctaggtctc
attgaggacc gatagagagc 89580agactgtgca acctttagag tctgcactgg gcctaggtct
cattgagggc agatagagac 89640catactgtgc aacctttaga gtctgcattg ggcctaggtc
tcactgagga gagatagaga 89700gcacactgtg taacctttag agactgcata gggcctcggt
ctcattgagg accgatagag 89760agcagactgt gccaccttta gagtctgcat tgggcctggg
tctcattgag gacaaataga 89820gagcagactg tgcaaccttt agagtctgca ttgggcctag
gtctcattga ggacagatgg 89880agagcagact gtgcaaccta tagagtctgc attgggccta
ggtctcattg aggacagatg 89940gaaagcagac tgtgcaacct ttagagtctg cattggacct
aggtctcatt gaggacagat 90000agagagcaga ctatgcaaac tttagaggct ggactgagcc
taggtctcat tgaggacaga 90060tagagagcag actgtgcaac ctttacagtc tgcattgggc
ctgggcctca ttcaggacag 90120atagagacca gactgcgcaa cctttagagt ctgcattggg
cctaggtctc attgagagta 90180gatagagagc agactgtgca acctttagag tctacattgg
gcctaggtct cattgagggc 90240agatggagag cagactgtgc aacctttaga gtctgcactt
ggcctaggtc tcattgagga 90300cacatagaga gcagactgtg caacctttag agtctgcatt
gggcctaggt ctcattgagg 90360gcagatagag agcagactgt gcaaacttta gagtttgcat
tgggcctagg tctcattgag 90420gagagataga gagcagactg tgcaaccttt agagtctgca
ttgggcctag gtctcattga 90480ggacagatgg agagcacact gtgcaacctt tagagtccgc
attgggccta ggtctcattg 90540aggacagata gagaccagac tgtgcaacct ttagtgtttg
cattgggcct aggtctcatt 90600gagggcagat agagagcaga atgtgcaacc cttagagtct
gcattgggcc taggtctcat 90660tgaggacaga tagagagcag actgtgcaac ctttagagtc
tgcactgggc ctaggtctct 90720ttgaggacag acagagagca gactgtgcaa actttagagt
ctgcactggg cctaggtctc 90780attgaggaca catagagagc agactgtgca acctttagag
tctgcattgg gcctatgtct 90840cattgaggac agttagagag cagactgtgc aaactttaga
gtctgcattt ggcctacgtc 90900tcattgagga caaaaagaga ccagagtgtg caacctttag
agtcggcatt gggactcggt 90960ctcattgagg acagatagag agcagactgt agaaccttca
tagtctgcat tgggcctagg 91020tctcattgag gtcagataga gagcagactg tgcaagcttt
agagtctgca cttggcctag 91080gtctcattga ggacagatag agagcagact gtgcaaactt
tagagtctgc attgggccta 91140ggtctcattg agggcagata gagaccagac tatgcaacgt
ttagagtctg cattgggcct 91200aggtgtcatt gagggcagtt agagagcaga ctgtgcaacc
tttagaatct gcattgggcc 91260taggtctcat tgagagcaga tagagagcac actgtgcaaa
ctttagagtc ggcattgggc 91320ctaggtctca ttgaggacag atagagaccg gactgtgcaa
cctttagagt ctgcattggg 91380cctaggtctc attgaggaca gatagagagc acactaggca
accattagag tccgcactgg 91440tcctaggtct cattgaggac agatatagag cagactgtgc
aacctttaga gtctgcattg 91500ggcctgggtc tcattgagga cagatagcga ccagactgta
caacctttag agtctgcatt 91560gggcttaggt ctcattgagg gcagttagag agcagactgt
gcaaccttta gagtctgcat 91620tgggcctagg tctcattgag agcagataga gagcacactg
tgcaacctct agagtcggca 91680ttgggcctag gtctcattga ggacagatag agaccagact
gttgaaactt tagaggctgc 91740attgggccta ggtctcattg aggacagata gagggcagac
tgtgcaacct ttagagtctg 91800caatggacct aggtctcatt gaggacagat acggagcaga
ctgtgcaaac tttaaagtct 91860gcactgagcc taggtctcat tgagggcaga tagagaccag
actgtgcaac ctttagagtc 91920tgcattgggt ctaggtctca ctgaggcgag atagagagca
gactttgcaa actttagagt 91980ctccattggg tctaggtctc actgaggact gataggagca
gactatgcaa cctttagagt 92040ctgcactggc cctaggtctc attgaggaca gatagagagc
agactgcgca aactttagag 92100tctgcattgg gcctaggtct cactgaggac agatagagag
cacactgtgt aacctttaga 92160gtctgcatag agcctcggtc tcattgagga cagatagaga
gcagactgtg caacctttag 92220agtctctatt gggcctagat ctcattgagg acagataggg
agcggactgt gcaaccttta 92280gagtctgcat tgggcctagg tctcattgag ggcagataga
gagcaggctc ggcaaccctt 92340agagtctgca ttgggcctag atcttattga ggacagatag
agagcatact atgcaacctt 92400gagagtctgc actgggccta ggtctcattg aggacacata
gagagcagac tgtgcaacct 92460ttagagtctg cattgggcct atgtctcatt gaggacagtt
agagagcaga ctgtgcaacc 92520tttagagtct gcatttggcc taggtctcat tgaggacaga
aagagaccag agtgtgcaac 92580ctttagagtt tgcattgggc ctaggtctca ttgaggacag
atagagagca gactgtagaa 92640cctttatagt ctgcattggg cctaggtctc attgaggtca
gatagagagc agactgtgca 92700agctttagag tctacacttg gcctaggtct cattgaggac
agatagagaa cagactgtgc 92760aaactttaga gtctgcattg ggcctaggtc tcattgaggg
cagttagaga gcagactgtg 92820caacctttag agtctgcatt gggcctaggt ctcattgaga
gcagatagag agcacactgt 92880gcaacctcta gagtcggcat tgggcctagg tctcattgag
gacagataga gaccagactg 92940tgcaaacttt agagtctgca ttgggcctag gtctcattga
ggacagatag agggcagact 93000gtgcaacgtt tagagtctgc attgggccta ggtctcattg
aggacagata gagagcagac 93060tgtgaaacct ttagagtctg cactgggcct aggtctcatt
gagggcagat agagaccata 93120ctgtgcaacc tttagagtct gcattgggtc taggtctcac
tgaggagaga tagagagcag 93180actttgcaaa ctttagagtc tacattaggt ctacgtctca
ctgaggactg atagagagca 93240gactatgcaa cctttagagt ctgcactggc cctaggtctc
attgaggaca catagagagc 93300agactgcgca aactttagag tttgcattgg gcctaggtct
cactgaggac agatagagag 93360cacactgtgt aacctttaga gtctgcgtag ggcctcggtc
tcattgagga ccgatagaga 93420gcagactgtg ccacctttag agtctgcatt gggcctgggt
ctcatggagg agaaatagag 93480agcagactgt gcaaccttta gagtctgcat tgggcctagg
tctcattgag gacagatgga 93540gagcagactg tgcaaccttt agagtctgca ttgggtctat
gtctcattga gggcagatag 93600agaccagact gtgcaacctt tagagtttgc attgggccta
ggtctcattg agggcagata 93660gagagcagac tgtgccacct ttagagtcta cattgggcct
aggtctcatt gaggacagat 93720agagagcaga ctgtgcaacc tttatagtct gcactgggcc
taggtctctt tgaggacaga 93780cagagagcag actgtgcaaa ctttagagtc tgcactgggc
ctaggtgtca ttgaggacag 93840atagagacca gactgtgcaa cctttagagt ctgcattggg
cctaggtctc cttgaggtca 93900gataggcagc agactgtgca acctttagag tctgcattgg
gtctaggtct aattgcggac 93960agatggagag cagactatgc aaagtttaca gtctgcattg
ggcctgggtc tcattgagga 94020cagatagaga gcagactgtg caacctttag agtctctatt
gggcctaggt ctcattgagg 94080acagatagag agcagactgt gcaaccttta gagtctgcat
tgggcctagg tctcattgag 94140ggcagataga gagcaggctc ggcaaccctt agagtctgcg
ttgggcttag atctcattga 94200ggacagatag agagcatact atgcaacctt tagagtctgc
actgggccta ggtctcattg 94260aggacacata gagagcagac tgtggaacct ttagagtctg
cattgggcct atgtctcaat 94320gaggacagtt agagagcaga ctgtgcaacc tttagagtct
gcattgggcc taggtctcat 94380tgaggacaga tagagagcag actgtagaac ctttatagtc
tgcattgggc ctaggtctca 94440ttgaggtcag atagagagca gactgtgcaa gctttagagt
ctgcacttgg cctaggtctc 94500attgaggaca gatagagagc agactgtgca acctttagag
tctgcattgg gcctaggtct 94560tattgagggc agatagagac cagactatgc aacgtttaga
gtctgcattg ggcctaggtg 94620tcattgaggg cagttagaga gcagactgtg ctacctttag
agtctgcatt aggcctaggt 94680ctcattgaga gcagatagag agcacactgt gcaaacttta
gagtcggcat tgggcctagg 94740tctcattgag gacagataga gaccggactg tgcaaccttt
agagtctgca ttgggcctag 94800gtctcattga ggacagataa agagcagact aggcaaccat
tagagtcggc actggtccta 94860agtctcattg aggacagata tagaggagac tgtgtaacct
ttagagtctg cattgggcct 94920gggtctcatt gaggacagat agagaacaga ctgtgcaacc
tttagagtct gcattgggtc 94980taggtctcat tgagggcagt tagagagcag actgtgccac
ctttagagtc tgcattgggc 95040ctaggtctca tcgacagcag atagagagca cactgtgcaa
cctctagagt cggcattggg 95100cctaggtctc attgaggaca gatagagacc agactgttaa
aactttagag tctgcattgg 95160gcctaggtct aattgaggac agatagaggg cagactgtgc
aacctttaga gtctgcattg 95220ggcctaggtc tcattgaggg cagatagaga gcaggctcgg
gaacccttag agtctgcatt 95280gggcctagat ctcattgagg acagatagag agcatactat
gcaaccttta gagtctgcat 95340tgggcctagg tctcattgag agcacataga gagcagactg
tgcaaccttt agagtctgca 95400ttgggcctat gtctcattga ggacagttag agagcaggct
gtgcaacctt tacagtctgc 95460atttggccta ggtctcattg aggacagaaa gagaccagag
tgcgcaaact ttagagtctg 95520cattgggcct aggtctcatt gaggacagat agagagcaga
ctgtagaacc tttatagtct 95580gcattgggcc taggtctcat tgaggtcaga tagagagcag
actgtgcaag ctttagagtc 95640tgcacttggc ctaggtctca ttgaggacag atagagaaca
gactgtgcaa cctttagagt 95700ctgcattggg cctaggtctc attgagggca gttagagagc
agactgtgca acctttagag 95760tctgcattgg gcctaggtct cattgagagc agatagagag
cacactgtgc aacctctaga 95820gtcggcattg ggcctaggtc tcattgagga cagatagaga
ccagactgtg caaactttag 95880agtctgcatt gggcctaggt ctcattgagg acagatagag
ggcagactgt gcaaccttta 95940gagtctgcat tgagcctagg tctcattgag gacagataga
gagcagactg tgcaaccttt 96000cgagtctgca ctgggcctag gtctcattga gggcatatag
agaccatact gtgcaaactt 96060tagagtctgc attgggtcta ggtctcactg aggagagata
gagagcagac tttgcaaact 96120ttagagtctg cattaggtct aggtctcact gaggactgat
agagagcaga ctatgcaact 96180ttagagtctg cactggccct aggtctcatt gaggacagat
agagagcaga ctgcgcaaac 96240tttagagtct gcattgggtc taggtctcat tgaggacaga
tagagagcac actgtgtaac 96300ctttagagtc tgcatagagc ctcggtctca ttgaggaccg
atagagagca gactgtgcca 96360cctttagagt ctgcattggg cctgggtctc actgaggaga
aatagagagc agactgtgca 96420acctttagag tctgcattgg gcctaggtct cattgaggac
agatggagag cagactgtgc 96480aacctttaga gtctgcattg ggcctaggtc tcattgaggg
cagatagaga gcagactgtg 96540caacctttag agtctgcatt gggcctaggt ctcattgaga
gcagatagag agcatactgt 96600gcaaccttta gagtcggcat tgggcctagg tctcattgag
gacagataga gaccagactg 96660tgcaaccttt agagtctgca ttgggcctag gtctcattga
ggacagatag agagcagact 96720atgcaaccat tagagtcgac actggtccta ggtctcattg
aggacagata tagagcagac 96780tgtgcaacct ttagagtctg cattgtgcat gggtctcatt
gaggacagat agagagcaga 96840ctaggcaacc attagagtcg acactggtcc taggtctaat
tgaggacaga tatagtgcag 96900actgtgcaac ctttagagtc tgcattgggc ctgggtctca
ttgaggacag atagagacca 96960gactgtgcaa cctttagagt ctgcactggg cctaggtctc
attgaggaca gatagagggc 97020agactgtgca acctttagag tctgcattgg gcctaggtct
cattgaggac agatagagag 97080cagactgtgc aacctttaga gtctgcactg ggcctaggtc
tcattgaggg cagatagaga 97140ccatactgtg caacctttag aatctgcatt gggtctaggt
ctcactgagg agagatagag 97200agcagacttt gcaaacttta gagtctgcat tgggtctagg
tctcactgag gactgataga 97260gagcagacta tgcaaccttt agagtctgca ctggcactag
gtctcattga ggacagatac 97320agagcagact gcgcaaactt tagagtctgc attgggccta
ggtctcattg aggacagata 97380gagagcacac tgtgtaacct ttagagtctg catagggcct
cggtctctat gaggaccgat 97440agagagcaga ctgtgcaacc tttagagtct gcattgggcc
tgggtctcat tgaggacaaa 97500tagagagcag actgtgcaac ctttagagtc tgcattgggc
ctaggtctca ttgaggagag 97560atggagagca gactgtgcaa cctttagagt ctgcattggg
cctaggtctc attgagagca 97620gatagagagc agagtgtgca acctttagag tctgcattgg
gcctaggtct cattgagggc 97680agatagagac cagactgtgc aacctttaga gtctgcattg
ggcctaggtc tcattgagag 97740cagatagaga gcagactgtg caacctttag agtctgcatt
gagcctaggt ctcattgagg 97800agagatagag agcagactgt gcaaccttta gagtctgcat
tgggcctagg tctcattgag 97860gacagatgga gagcacactg tgcaaccttt agagtccgca
ttgggcctag gtgtcattga 97920ggacagatag agaccagact gtgcaacctt tagagtctgc
attgggccta ggtctccttg 97980aggtcagata gacagcagac tctgcaacct ttagagtctg
cattgggcct aggtctaatt 98040gcggacagat agacagcaga ctgtgcaacg tttagagtct
gcattgggcc taggtctaat 98100tgcggacaga tagagagcag actatgcaac gtttagagtc
tgcattgggc ctgggtctca 98160ttgaggacag atagagagca gactgtgcaa cctttagagt
ctctattggg cctaggtctc 98220attgaggaca gatagggagc ggactgtgca acctttagag
tctgcattgg gcctaggtct 98280cattgacggc agacagagag caggctcggc aacccttaga
gtctgcattg ggcctagatc 98340tcattgagga cagatagaga gcatactatg caacctttag
agtctgcact gggcttagtt 98400ctcattgagg aaacatagag agcagactgt gcaaccttta
gagtctgcat taggcctatg 98460tctcattgag gacagttaga gagcagactg tgctaccttt
agagtctgca tttggcctag 98520gtctcattga gtacagaaag agaccagagt gtgcaacctt
tagagtctgc attgggcctg 98580ggtctcattg aggacagata gagaggagac tgtagaacct
ttatagtctg cattgggcct 98640aggtctcatt gaggtcagat agggagcaga ctgggcaagc
tttagagtct gcacttggcc 98700taggtctcat tgaggacaga tagagaacag actgtgcaac
ctttagagtc tgcattcggc 98760ctaggtctca ttgagggcag ttagagagca gactgtgcaa
cctttagagt ctgcattggg 98820cctaggtctc attgagagca gatagagagc acactgtgca
acctctagag tcggcattgg 98880gcctaggtct cattgaggac agatagagac cagactgtgc
aaactttaga gtctgcattg 98940ggcctaggtc tcattgagga cagatacagg gcagactgtg
caacctttag agtctgcatt 99000gggcctaggt ctcattgagg tcagatagag agcagactgt
gcaaccttta gagtctgcac 99060tgggcctagg tctcattgag ggcagataga gaccatactg
tgcaaccttt agagtctgca 99120ttgggtctag gtctcactga ggagagatag agagcagact
ttgcaaactt tagagtctgc 99180attaggtcta ggtctcactg aggactgata gagagcagat
tatgcaacct ttagagtctg 99240cactggccct aggtctcatt gaggacagat agagagcaga
ctgcgcaaac tttagagtct 99300gcattgggcc taggtctcat tgaggacaga tagagagcac
actgtgtaac ctttagagtc 99360tgcatagggc ctcggtctca ttgaggaccg atagagagca
gactgtgcca cctttagagt 99420ctgcattggg cctgggtctc attgaggaga aatagagagc
agactgtgca acctttagag 99480tctgcattgg gcctaggtct cattgaggac agatggagag
cagactgtgc aacctttaga 99540gtctgcattg ggcctaggtc tcattgaggg cacatagaga
gcagactgtg caacctttag 99600agtctgcatt gggcctaggt ctcattgaga gaagatagag
agcatacagt gcaaccttta 99660gagtcggcat tgggcctagg tctcattgag gacagataga
gaccagactg tgaaaccttt 99720agagtctgca ttgggcctag gtctcattga ggacagatag
agagcagagt aggcaaccat 99780tagagtcggc actggtccta ggtctcattg aggacagata
tagagcagac tgtgcaacct 99840ttagagtctg cattgggcct gggtctcatt gaggacagat
agagagcaga ctgtgcaacc 99900tttagaggct gcactgggcc taggtctcat tgaggacaga
tagagggcag actgtgcaac 99960ctttagagtc tgcattgggc ctaggtctca ttgaggaccg
atagagagca gactgtgcaa 100020cctttagagt ctgcactggg cctaggtctc attgagggca
gatagagacc atactgtgca 100080acctttagag tctgcattgg gcctaggtct cactgaggag
agatagagag cacactgtgt 100140aacctttaga gactgcatag ggcctcggtc tcattgagga
ccgatagaga gcagactgtg 100200ccacctttag agtctgcatt gggcctgggt ctcattgagg
acaaatagag agcagactgt 100260gcaaccttta gagtctgcat tgggcctagg tctcattgag
gacagatgga gagcagactg 100320tgcaacctat agagtctgca ttgggcctag gtctcattga
ggacagatgg aaagcagact 100380gtgcaacctt tagagtctgc attggaccta ggtctcattg
aggacagata gagagcagac 100440tatgcaaact ttagaggctg gactgagcct aggtctcatt
gaggacagat agagagcaga 100500ctgtgcaacc tttacagtct gcattgggcc tgggcctcat
tcaggacaga tagagaccag 100560actgcgcaac ctttagagtc tgcattgggc ctaggtctca
ttgagagtag atagagagca 100620gactgtgcaa cctttagagt ctacattggg cctaggtctc
attgagggca gatagagagc 100680agactgtgca acctttagag tctgcacttg gcctaggtct
cattgaggac acatagagag 100740cagactgtgc aacctttaga gtctgcattg ggcctaggtc
tcgttgaggg cagatagaga 100800gcagactgtg caaactttag agtttgcatt gggcctaggt
ctcattgagg agagatagag 100860agcagactgt gcaaccttta gagtctgcat tgggcctagg
tctcattgag gacagatgga 100920gagcacactg tgcaaccttt agagtccgca ttgggcctag
gtctcattga ggacagatag 100980agaccagact gtgcaacctt tagtgtttgc attgggccta
ggtctcattg agggcagata 101040gagagcagaa tgtgcaaccc ttagagtctg cattgggcct
aggtctcatt gaggacagat 101100agagagcaga ctgtgcaacc tttagagtct gcactgggcc
taggtctctt tgaggacaga 101160cagagagcag actgtgcaaa ctttagagtc tgcactgggc
ctaggtctca ttgaggacag 101220atatagagga gactgtgtaa cctttagagt ctgcattggg
cctgggtctc attgaggaca 101280gatagagaac agactgtgca acctttagag tctgcattgg
gtctaggtct cattgagggc 101340agttagagag cagactgtgc cacctttaga gtctgcattg
ggcctaggtc tcatcgacag 101400cagatagaga gcacactgtg caacctctag agtcggcatt
gggcctaggt ctcattgagg 101460acagatagag accagactgt taaaacttta gagtctgcat
tgggcctagg tctaattgag 101520gacagataga gggcagactg tgcaaccttt agagtctgca
ttgggcctag gtctcattga 101580gggcagatag agagcaggct cgggaaccct tagagtctgc
attgggccta gatctcattg 101640aggacagata gagagcatac tatgcaacct ttagagtctg
cattgggcct aggtctcatt 101700gagagcacat agagagcaga ctgtgcaacc tttagagtct
gcattgggcc tatgtctcat 101760tgaggacagt tagagagcag gctgtgcaac ctttacagtc
tgcatttggc ctaggtctca 101820ttgaggacag aaagagacca gagtgcgcaa actttagagt
ctgcattggg cctaggtctc 101880attgaggaca gatagagagc agactgtaga acctttatag
tctgcattgg gcctaggtct 101940cattgaggtc agatagagag cagactgtgc aagctttaga
gtctgcactt ggcctaggtc 102000tcattgagga cagatagaga acagactgtg caacctttag
agtctgcatt gggcctaggt 102060ctcattgagg gcagttagag agcagactgt gcaaccttta
gagtctgcat tgggcctagg 102120tctcattgag agcagataga gagcacactg tgcaacctct
agagtcggca ttgggcctag 102180gtctcattga ggacagatag agaccagact gtgcaaactt
tagagtctgc attgggccta 102240ggtctcattg aggacagata gagggcagac tgtgcaacct
ttagagtctg cattgagcct 102300aggtctcatt gaggacagat agagagcaga ctgtgcaacc
tttcgagtct gcactgggcc 102360taggtctcat tgagggcata tagagaccat actgtgcaaa
ctttagagtc tgcattgggt 102420ctaggtctca ctgaggagag atagagagca gactttgcaa
actttagagt ctgcattagg 102480tctaggtctc actgaggact gatagagagc agactatgca
actttagagt ctgcactggc 102540cctaggtctc attgaggaca gatagagagc agactgcgca
aactttagag tctgcattgg 102600gtctaggtct cattgaggac agatagagag cacactgtgt
aacctttaga gtctgcatag 102660agcctcggtc tcattgagga ccgatagaga gcagactgtg
ccacctttag agtctgcatt 102720gggcctgggt ctcactgagg agaaatagag agcagactgt
gcaaccttta gagtctgcat 102780tgggcctagg tctcattgag gacagatgga gagcagactg
tgcaaccttt agagtctgca 102840ttgggcctag gtctcattga gggcagatag agagcagact
gtgcaacctt tagagtctgc 102900attgggccta ggtctcattg agagcagata gagagcatac
tgtgcaacct ttagagtcgg 102960cattgggcct aggtctcatt gaggacagat agagaccaga
ctgtgcaacc tttagagtct 103020gcattgggcc taggtctcat tgaggacaga tagagagcag
actatgcaac cattagagtc 103080gacactggtc ctaggtctca ttgaggacag atatagagca
gactgtgcaa cctttagagt 103140ctgcattgtg catgggtctc attgaggaca gatagagagc
agactaggca accattagag 103200tcgacactgg tcctaggtct aattgaggac agatatagtg
cagactgtgc aacctttaga 103260gtctgcattg ggcctgggtc tcattgagga cagatagaga
ccagactgtg caacctttag 103320agtctgcact gggcctaggt ctcattgagg acagatagag
ggcagactgt gcaaccttta 103380gagtctgcat tgggcctagg tctcattgag gacagataga
gagcagactg tgcaaccttt 103440agagtctgca ctgggcctag gtctcattga gggcagatag
agaccatact gtgcaacctt 103500tagaatctgc attgggtcta ggtctcactg aggagagata
gagagcagac tttgcaaact 103560ttagagtctg cattgggtct aggtctcact gaggactgat
agagagcaga ctatgcaacc 103620tttagagtct gcactggcac taggtctcat tgaggacaga
tacagagcag actgcgcaaa 103680ctttagagtc tgcattgggc ctaggtctca ttgaggacag
atagagagca cactgtgtaa 103740cctttagagt ctgcataggg cctcggtctc tatgaggacc
gatagagagc agactgtgca 103800acctttagag tctgcattgg gcctgggtct cattgaggac
aaatagagag cagactgtgc 103860aacctttaga gtctgcattg ggcctaggtc tcattgagga
gagatggaga gcagactgtg 103920caacctttag agtctgcatt gggcctaggt ctcattgaga
gcagatagag agcagagtgt 103980gcaaccttta gagtctgcat tgggcctagg tctcattgag
ggcagataga gaccagactg 104040tgcaaccttt agagtctgca ttgggcctag gtctcattga
gagcagatag agagcagact 104100gtgcaacctt tagagtctgc attgagccta ggtctcattg
aggagagata gagagcagac 104160tgtgcaacct ttagagtctg cattgggcct aggtctcatt
gaggacagat ggagagcaca 104220ctgtgcaacc tttagagtcc gcattgggcc taggtgtcat
tgaggacaga tagagaccag 104280actgtgcaac ctttagagtc tgcattgggc ctaggtctcc
ttgaggtcag atagacagca 104340gactctgcaa cctttagagt ctgcattggg cctaggtcta
attgcggaca gatagacagc 104400agactgtgca acgtttagag tctgcattgg gcctaggtct
aattgcggac agatagagag 104460cagactatgc aacgtttaga gtctgcattg ggcctgggtc
tcattgagga cagatagaga 104520gcagactgtg caacctttag agtctctatt gggcctaggt
ctcattgagg acagataggg 104580agcggactgt gcaaccttta gagtctgcat tgggcctagg
tctcattgac ggcagacaga 104640gagcaggctc ggcaaccctt agagtctgca ttgggcctag
atctcattga ggacagatag 104700agagcatact atgcaacctt tagagtctgc actgggctta
gttctcattg aggaaacata 104760gagagcagac tgtgcaacct ttagagtctg cattaggcct
atgtctcatt gaggacagtt 104820agagagcaga ctgtgctacc tttagagtct gcatttggcc
taggtctcat tgagtacaga 104880aagagaccag agtgtgcaac ctttagagtc tgcattgggc
ctgggtctca ttgaggacag 104940atagagagga gactgtagaa cctttatagt ctgcattggg
cctaggtctc attgaggtca 105000gatagggagc agactgggca agctttagag tctgcacttg
gcctaggtct cattgaggac 105060agatagagaa cagactgtgc aacctttaga gtctgcattc
ggcctaggtc tcattgaggg 105120cagttagaga gcagactgtg caacctttag agtctgcatt
gggcctaggt ctcattgaga 105180gcagatagag agcacactgt gcaacctcta gagtcggcat
tgggcctagg tctcattgag 105240gacagataga gaccagactg tgcaaacttt agagtctgca
ttgggcctag gtctcattga 105300ggacagatac agggcagact gtgcaacctt tagagtctgc
attgggccta ggtctcattg 105360aggtcagata gagagcagac tgtgcaacct ttagagtctg
cactgggcct aggtctcatt 105420gagggcagat agagaccata ctgtgcaacc tttagagtct
gcattgggtc taggtctcac 105480tgaggagaga tagagagcag actttgcaaa ctttagagtc
tgcattaggt ctaggtctca 105540ctgaggactg atagagagca gattatgcaa cctttagagt
ctgcactggc cctaggtctc 105600attgaggaca gatagagagc agactgcgca aactttagag
tctgcattgg gcctaggtct 105660cattgaggac agatagagag cacactgtgt aacctttaga
gtctgcatag ggcctcggtc 105720tcattgagga ccgatagaga gcagactgtg ccacctttag
agtctgcatt gggcctgggt 105780ctcattgagg agaaatagag agcagactgt gcaaccttta
gagtctgcat tgggcctagg 105840tctcattgag gacagatgga gagcagactg tgcaaccttt
agagtctgca ttgggcctag 105900gtctcattga gggcacatag agagcagact gtgcaacctt
tagagtctgc attgggccta 105960ggtctcattg agagaagata gagagcatac agtgcaacct
ttagagtcgg cattgggcct 106020aggtctcatt gaggacagat agagaccaga ctgtgaaacc
tttagagtct gcattgggcc 106080taggtctcat tgaggacaga tagagagcag agtaggcaac
cattagagtc ggcactggtc 106140ctaggtctca ttgaggacag atatagagca gactgtgcaa
cctttagagt ctgcattggg 106200cctgggtctc attgaggaca gatagagagc agactgtgca
acctttagag gctgcactgg 106260gcctaggtct cattgaggac agatagaggg cagactgtgc
aacctttaga gtctgcattg 106320ggcctaggtc tcattgagga ccgatagaga gcagactgtg
caacctttag agtctgcact 106380gggcctaggt ctcattgagg gcagatagag accatactgt
gcaaccttta gagtctgcat 106440tgggcctagg tctcactgag gagagataga gagcacactg
tgtaaccttt agagactgca 106500tagggcctcg gtctcattga ggaccgatag agagcagact
gtgccacctt tagagtctgc 106560attgggcctg ggtctcattg aggacaaata gagagcagac
tgtgcaacct ttagagtctg 106620cattgggcct aggtctcatt gaggacagat ggagagcaga
ctgtgcaacc tatagagtct 106680gcattgggcc taggtctcat tgaggacaga tggaaagcag
actgtgcaac ctttagagtc 106740tgcattggac ctaggtctca ttgaggacag atagagagca
gactatgcaa actttagagg 106800ctggactgag cctaggtctc attgaggaca gatagagagc
agactgtgca acctttacag 106860tctgcattgg gcctgggcct cattcaggac agatagagac
cagactgcgc aacctttaga 106920gtctgcattg ggcctaggtc tcattgagag tagatagaga
gcagactgtg caacctttag 106980agtctacatt gggcctaggt ctcattgagg gcagatagag
agcagactgt gcaaccttta 107040gagtctgcac ttggcctagg tctcattgag gacacataga
gagcagactg tgcaaccttt 107100agagtctgca ttgggcctag gtctcgttga gggcagatag
agagcagact gtgcaaactt 107160tagagtttgc attgggccta ggtctcattg aggagagata
gagagcagac tgtgcaacct 107220ttagagtctg cattgggcct aggtctcatt gaggacagat
ggagagcaca ctgtgcaacc 107280tttagagtcc gcattgggcc taggtctcat tgaggacaga
tagagaccag actgtgcaac 107340ctttagtgtt tgcattgggc ctaggtctca ttgagggcag
atagagagca gaatgtgcaa 107400cccttagagt ctgcattggg cctaggtctc attgaggaca
gatagagagc agactgtgca 107460acctttagag tctgcactgg gcctaggtct ctttgaggac
agacagagag cagactgtgc 107520aaactttaga gtctgcactg ggcctaggtc tcattgagga
cacatagaga gcagactgtg 107580caacctttag agtctgcatt gggcctatgt ctcattgagg
acagttagag agcagactgt 107640gcaaacttta gagtctgcat ttggcctacg tctcattgag
gacaaaaaga gaccagagtg 107700tgcaaccttt agagtcggca ttgggactcg gtctcattga
ggacagatag agagcagact 107760gtagaacctt catagtctgc attgggccta ggtctcattg
aggtcagata gagagcagac 107820tgtgcaagct ttagagtctg cacttggcct aggtctcatt
gaggacagat agagagcaga 107880ctgtgcaaac tttagagtct gcattgggcc taggtctcat
tgagggcaga tagagaccag 107940actatgcaac gtttagagtc tgcattgggc ctaggtgtca
ttgagggcag ttagagagca 108000gactgtgcaa cctttagaat ctgcattggg cctaggtctc
attgagagca gatagagagc 108060acactgtgca aactttagag tcggcattgg gcctaggtct
cattgaggac agatagagac 108120cggactgtgc aacctttaga gtctgcattg ggcctaggtc
tcattgagga cagatagaga 108180gcacactagg caaccattag agtccgcact ggtcctaggt
ctcattgagg acagatatag 108240agcagactgt gcaaccttta gagtctgcat tgggcctggg
tctcattgag gacagatagc 108300gaccagactg tacaaccttt agagtctgca ttgggcttag
gtctcattga gggcagttag 108360agagcagact gtgcaacctt tagagtctgc attgggccta
ggtctcattg agagcagata 108420gagagcacac tgtgcaacct ctagagtcgg cattgggcct
aggtctcatt gaggacagat 108480agagaccaga ctgttgaaac tttagaggct gcattgggcc
taggtctcat tgaggacaga 108540tagagggcag actgtgcaac ctttagagtc tgcaatggac
ctaggtctca ttgaggacag 108600atacggagca gactgtgcaa actttaaagt ctgcactgag
cctaggtctc attgagggca 108660gatagagacc agactgtgca acctttagag tctgcattgg
gtctaggtct cactgaggcg 108720agatagagag cagactttgc aaactttaga gtctccattg
ggtctaggtc tcactgagga 108780ctgataggag cagactatgc aacctttaga gtctgcactg
gccctaggtc tcattgagga 108840cagatagaga gcagactgcg caaactttag agtctgcatt
gggcctaggt ctcactgagg 108900acagatagag agcacactgt gtaaccttta gagtctgcat
agagcctcgg tctcattgag 108960gacagataga gagcagactg tgcaaccttt agagtctcta
ttgggcctag atctcattga 109020ggacagatag ggagcggact gtgcaacctt tagagtctgc
attgggccta ggtctcattg 109080agggcagata gagagcaggc tcggcaaccc ttagagtctg
cattgggcct agatcttatt 109140gaggacagat agagagcata ctatgcaacc ttgagagtct
gcactgggcc taggtctcat 109200tgaggacaca tagagagcag actgtgcaac ctttagagtc
tgcattgggc ctatgtctca 109260ttgaggacag ttagagagca gactgtgcaa cctttagagt
ctgcatttgg cctaggtctc 109320attgaggaca gaaagagacc agagtgtgca acctttagag
tttgcattgg gcctaggtct 109380cattgaggac agatagagag cagactgtag aacctttata
gtctgcattg ggcctaggtc 109440tcattgaggt cagatagaga gcagactgtg caagctttag
agtctacact tggcctaggt 109500ctcattgagg acagatagag aacagactgt gcaaccttta
gagtctgcat tgggcctagg 109560tctcattgag ggcagataga gaccagactg tgcaaccttt
agagtttgca ttgggcctag 109620gtctcattga gggcagatag agagcagact gtgccacctt
tagagtctac attgggccta 109680ggtctcattg aggacagata gagagcagac tgtgcaacct
ttatagtctg cactgggcct 109740aggtctcttt gaggacagac agagagcaga ctgtgcaaac
tttagagtct gcactgggcc 109800taggtgtcat tgaggacaga tagagaccag actgtgcaac
ctttagagtc tgcattgggc 109860ctaggtctcc ttgaggtcag ataggcagca gactgtgcaa
cctttagagt ctgcattggg 109920tctaggtcta attgcggaca gatggagagc agactatgca
aagtttacag tctgcattgg 109980gcctgggtct cattgaggac agatagagag cagactgtgc
aacctttaga gtctctattg 110040ggcctaggtc tcattgagga cagatagaga gcagactgtg
caacctttag agtctgcatt 110100gggcctaggt ctcattgagg gcagatagag agcaggctcg
gcaaccctta gagtctgcgt 110160tgggcttaga tctcattgag gacagataga gagcatacta
tgcaaccttt agagtctgca 110220ctgggcctag gtctcattga ggacacatag agagcagact
gtggaacctt tagagtctgc 110280attgggccta tgtctcaatg aggacagtta gagagcagac
tgtgcaacct ttagagtctg 110340cattgggcct aggtctcatt gaggacagat agagagcaga
ctgtagaacc tttatagtct 110400gcattgggcc taggtctcat tgaggtcaga tagagagcag
actgtgcaag ctttagagtc 110460tgcacttggc ctaggtctca ttgaggacag atagagagca
gactgtgcaa cctttagagt 110520ctgcattggg cctaggtgtc attgagggca gatagagacc
agactatgca acgtttagag 110580tctgcattgg gcctaggtgt cattgagggc agttagagag
cagactgtgc tacctttaga 110640gtctgcatta ggcctaggtc tcattgagag cagatagaga
gcacactgtg caaactttag 110700agtcggcatt gggcctaggt ctcattgagg acagatagag
accggactgt gcaaccttta 110760gagtctgcat tgggcctagg tctcattgag gacagataaa
gagcagacta ggcaaccatt 110820agagtcggca ctggtcctaa gtctcattga ggacagatat
agaggagact gtgtaacctt 110880tagagtctgc attgggcctg ggtctcattg aggacagata
gcgaccagac tgtgcaacct 110940ttagagtctg cattgggtct aggtctcatt gagggcagtt
agagagcaga ctgtgccacc 111000tttagagtct gcattgggcc taggtctcat cgacagcaga
tagagagcac actgtgcaac 111060ctctagagtc ggcattgggc ctaggtctca ttgaggacag
atagagacca gactgttaaa 111120actttagagt ctgcattggg cctaggtcta attgaggaca
gatagagggc agactgtgca 111180acctttagag tctgcattgg gcctaggtct cattgaggac
agatacagag cagactgtgc 111240aaactttaaa gtctgcactg aacctaggtc tcattgaggg
cagatagaga ccataatgtg 111300caacctttag agtctgcatt gggtctaggt ctcactgagg
agagatagag agcagacttt 111360gcaaacttta gagtctccat tgggtctagg tctcactgag
gactgataga gagcagacta 111420tgcaaccttt agagtctgca ctggccctag gtctcattga
ggacacatag agagcagact 111480gcgcaaactt tagagtctgc attgggccta ggtctcactg
aggacagata gagagcacac 111540tgtgtaacct ttagagtctg catagggcct cggtctcatt
gaggaccgat agagagcaga 111600ctgtgccacc tttagagtct gcattgggcc tgggtctcat
tgaggacaaa tagagagcag 111660actgtgcaac ctttagagtc tgcattgggc ctaggtctca
ttgaggacag atagagagca 111720gactgtgcaa cctttagagt ctgcattggg cctaggtctc
attgagggca gatagagagc 111780agactgtgca acctttagag tctgcactgg gcctaggtct
catcgaggac agatagagag 111840cagactgtgc aacctttaga gtctgcattg gacctaggtc
tcattgagga cagatagaga 111900gcagactatg caaactttac agtctgcact gggcctaggt
ctcattgagg acagatagag 111960accagagtgt gcaaccttta gagtctgcat tgggcctagg
tctcattgag gacagacaga 112020gagcagactg tagaaccttt atagtctgca ttgggcctag
gtctcattga ggtcagatag 112080agagcagact gtgcaagctt tagagtctgc acttggccta
ggtctcattg aggacagata 112140gagagcagac tgtgcaacct ttagagtctg cattgggcct
aggtctcatt gaggacagat 112200agagaccaga ctgtgcaacc tttatagtct gcactgggcc
taggtctcat tgaggagaga 112260tagagagcag actgcgcaac ctttagagtc ttcattgggc
ctaggtctca ttgagggcag 112320atagagacca gagtgttcaa cctttagagt ctgcattggg
cctaggtctc attgaggaca 112380gatagagagc agactgtaga aactttatag tctgcattgg
gcctaggtct cattgaggtc 112440agatagagaa cagactgtgc aagctttaga gtctgcactt
ggcctaggtc tcattgagga 112500cagatagaga acagactgtg caacctttag agtctgcact
aggcctaggt ctcattgagg 112560acagatagag agcagactgt gcaaccttta gagtctgcat
tggacctagg tctcattgag 112620gacagataga gagcagacta tgcaaacttt agaggctgca
ctgagcctag gtctcattga 112680ggacagatag agagcagact gtgcaacctt tacagtctgc
attggatctg ggcctcattc 112740aggacagata gagaccagac tgtgcaacct ttagagtctg
cattgggcct aggtctcatt 112800gagagcagat agagagcaga ctgtgcaacc tttagagtct
gcattgggcc taggtctcat 112860tgagggcaga tagagagcag actgtgcaaa ctttagagtc
tgcattgggc ctaggtctca 112920ttgaggagag atagagagca gactgtgcaa cctttagagt
ctgcattggg cctaggtctc 112980attgaggaca gatggagagc acactgtgca acctttagag
tccgcattgg gcctaggtct 113040cattgaggac agatagagac cagactgtgc aactttagag
tctgcattgg gcctaggtct 113100cattgagggc agatagagag cagactgtgc aacctttaga
gtctgcactg ggcctaggtc 113160tcattgagga cagatagaga gcagactgtg caacctttag
agtctgcact gtgcctaggt 113220ctctttgagg acagacagag agcagactgt gcaaacttta
gagtctgcac tgggcctagg 113280tgtcattgag gacagataga gaccagactg tgcaaccttt
agagtctgca ttgggcctaa 113340gtctccttga ggtcagatag acagcagact gtgcaacctt
tagagtctgc attgggccta 113400ggtctaattg cggacagaca gagagcagac tatgcaacgt
ttagagtctg cattgggcct 113460gggtctcatt gaggacagat agagtgcaga ctgtgcaacc
tttagagtct ctattgggcc 113520taggtctcat tgaggacaga tagagagcgg actgtgcaac
ctttagagtc tgcattgggc 113580ctaggtctca ttgagggcag atagagagca ggctcggcaa
cccttagagt ctgcattggg 113640cttagatctc attgaggaca gatagagagc atactatgca
acctttagag tctgcactgg 113700gcctaggtct cattgaggac acatagagag cagactgtgc
aacctttaga gtctgcattg 113760ggcctatgtc tcattgagga cagttagaga gcagactgtg
caacctttag agtctgcatt 113820tggcctaggt ctcattgagg acagaaagag accagagtgt
gcaaccttta gagtctgcat 113880tgggcctagg tctcattgag gacagataga gagcagactg
tagaaccttt atagtctgca 113940ttgggcctag gtctcattga ggtcagatag agagcagact
gtgcaagctt tagagtctgc 114000acttggccta ggtctcattg aggacagata gagagcagac
tgtgcaacct ttagagtctg 114060cattgggcct aggtctcatt gagggcagat agagaccaga
ctatgcaacg tttagagtct 114120gcattgggcc taggtgtcat tgagggcagt tagagagcag
actgtgctac ctttagagtc 114180tgcattgggc ctaggtctca ttgagagcag atagagagca
cactgtgcaa actttagagt 114240cggcattggg cctaggtctc attgaggaca gatagagacc
ggactgtgca acctttagag 114300tctgcattgg gcctaggtct cattgaggac agataaagag
cagactaggc aaccattaga 114360gtcggcactt ttcctaggtc tcattgagga cagatataga
gcagactgtg caacctttag 114420agtctgcatt gggtctgggt ctcattgagg acagatagcg
accagactgt gcaaccttta 114480gagtctgctt tgggcttagg tctcattgag ggcagttaga
gagcagactg tgcaaccttt 114540agagtctgca ttgggtctag gtctcattga gagcagatag
agagcacact gtgcaacctc 114600tagagtcggc attgggccta ggtctcattg aggacagata
gagaccagac tgttaaaact 114660ttagagtctg cattgggcct aggtctcatt gaggacagat
agagggcaga ctgtgcaacc 114720tttagagtct gcattggtcc taggtctcat tgaggacaga
tagagagcag actgcgcaaa 114780ctttagagtc tgcattgggc ctaggtctca ctgaggacag
atagagagca cactgtgtaa 114840cctttagagt ctgcataggg cctcggtctc attgaggacc
gatagagagc agactgtgca 114900acctttagag tctgcattgg gcctgggtct cattgaggac
aaatagagag cagactgtgc 114960aacctttaga gtctgcattg ggcctaggtc tcattgagga
cagatagaga gcagactgtg 115020caacctttag agtctgcatt gggcctaggt ctcattgagg
gcagatagag agcagactgt 115080gcaaccttta gagtctgcac taggcctagg tctcatcgag
gacagataga gagcagactg 115140tgcaaccttt agagtctgca ttggacctag gtctcattga
ggacagatag aaagcagact 115200atgcaaactt tacagtctgc actgggccta ggtctcattg
aggacagata gagaccagag 115260tgtgcaacct ttagagtctg cattgggcct aggtctcatt
gaggacagat agagagcaga 115320ctgtagaacc tttatagtct gcattgggcc taggtctcat
tgaggtcaga tagagagcag 115380actgtgcaag ctttagagtc tgcacttggc ctaggtctca
ttgaggacag atagagagca 115440gactgtgcaa cctttagagt ctgcattggg cctaggtctc
attgaggaca gatagagacc 115500agactgtgca acctttatag tctgcactgg gcctaggtct
cattgaggac agatagagag 115560cagactgcgc aacctttaga gtcttcattg gtcctaggtc
tcattgaggg cagatagaga 115620ccagactatg caacctttag agtctgcatt gggcctaggt
ctcattgagg gcagatagag 115680agcagactgt gcaaccttta gagtatgcat tgggcctagg
tctcattgag ggcagataga 115740gagcagactg tgcaacgttt agagtctgca ttgtgcctaa
gtctcattga ggacagatag 115800agagcagact gtgcaacctt tcgagtctgc actgggccta
ggtctcattg agggcagata 115860gggaccagag tatgcaacct ttagagtctg cactgggcct
aggtctcatt gagggcagat 115920agagaccaga ctatgcaacc tttagagtct gcattgggac
cccagaaatc ctaaactttg 115980tgtggtctaa ggacggttgg agagccacgt ctggaccatc
cctgtggctg ccacctgaat 116040ggcggccagc acgagatctt atgcttgcac actgtgcctg
caagggtggg aggggctggc 116100ttatctcaga caacctcctg atagtggggt aaaccaaaaa
tagaattcta agcccctcag 116160ctgactgagt ggacctgttt gtagccaagg ggatcccaaa
gaaacctgaa aaacaactca 116220ggccgtgaca ggaagagggg atctcgggcc gtgacaggaa
gagggagtct cgggccgtga 116280caggaagagg gagtctcggg ccgtgacagg aagagggagt
ctcgggccgt gactggaaga 116340gggggtctcg ggccgtgaca ggaagagggg gtctcgggcc
gtgacaggaa gagggggtct 116400cgggccgtga caggaagagg gggtctcggg ccgtgacagg
aagagggggt ctcgggccgt 116460gacaggaaga gggggtctcg ggccgtgaca ggaagaggga
gtctcgggcc gtgacaggaa 116520gagggagtct cgggccgtga taggaagagg gagtctcggg
ccgtgacagg aagaggggat 116580ctcgggccgt gacaggaaga gggagtctcg ggccgtgaca
ggaagagggt atctgtcctc 116640aatgagacct aggcccaatg cagactctaa agtttgcaca
ctctggtctc tttctgtcct 116700caatgagacc taggccaaat gcagactcta aaggttgcac
agtctgctct ctaactgtcc 116760tcaatgagac ataggcccaa tgcagactct aaaggttgca
cagtctgctc tctatgtgtc 116820ctcaatgaga cctaggccca gtgcagactc taaaggttgc
atagcatgct ctctatctgt 116880cctcaatgat atctaggccc aatgcagact ctaagggttg
ccgagcctgc tctctatctg 116940ccctcaatga gacctaggcc caatgcagac tctaaaggtt
gcacagtccg ctccctatct 117000gtcctcaatg agacctaggc ccaatagaga ccctaaaggt
tgcacagtct gctctctatc 117060tgtcctcaat gagacccagg cccaatgcag actctaaacg
ttgcatagtc tgctctctat 117120ctgtccgcaa ttagacctag gcccaatgca gactctaaac
gttgcacagt ctgctgtcta 117180tctgtccgca attagaccta ggcccaatgc agactctaaa
ggttgcagag tctgctgtct 117240gtctgacctc aaggagacct aggcccaatg cagactctaa
aggttgcaca gtctggtctc 117300tatctgtcct caatgacacc taggcccagt gcagactcta
aagtttgcac attctgctct 117360ctgtctgtcc tcaaagagac ctagggccag tgcagactct
aaaggttgca cagtctcctc 117420tctatttgtc ctcactgata cctaggccca ttgtagactc
taaaggttgc acagtctgcc 117480ctctatctgt cctcaatgag acctaggccc aatgcagact
ctaaagtttc aacagtctgg 117540tctctatctg tcctcaatga gacctaggcc caatgccgac
tctagaggtt gcacagtgtg 117600ctctctatct gctctcaatg agacctaggc ccaatgcaga
ctctaaaggt tgcacagtct 117660gctctctaac tgccctcaat gagacctaag cccaatgcag
actctaaagg ttgcacagtc 117720tggtcgctat ctgtcctcaa tgagacccag gcccaatgca
gactctaaag gttgcacagt 117780ctgctctata tctgtcctca atgagaccta ggaccagtgc
cgactctaat ggttgcctag 117840tctgctctct atctgtcctc aatgagacgt aggcccaatg
cagactctaa aggttgcaca 117900gtccggtctc tatctgtcct caatgagacc taggcccaat
gccgactcta aagtttgcac 117960agtgtgctct ctatctgctc tcaatgagac ctaggcccaa
tgcagactct aaaggttgca 118020cagtctgctc tctaactgcc ctcaatgaga cctaggccca
atgcagactc taaacgttgc 118080atagtctggt ctctatctgc cctcaatgag acctaggccc
aatgcagact ctagagtttg 118140cacagtctgc tctctatctg tcctcaatga gacctaggcc
aagtgcagac tctaaagctt 118200gcaccgtctg ctctctatct gacctcaatg agacctaggc
ccaatgcaga ctataaagtt 118260tctacagtct gctctctatc tgtcctcaat gagacctagg
cccaatgctg actctaaagg 118320ttgcacactc tggtctgttt ctgtcctcaa tgagacctag
gccaaatgca gactctaaag 118380gttgcacagt ctgctctcta actgtcctca atgagacata
ggcccaatgc agactctaaa 118440ggttgcacag tctgctctct atgtgtcctc aatgagacct
aggcccaatg cagactctaa 118500aggttgcata gtatgctctc tatctgtcct caataagatc
taggcccaat gcagactcta 118560agggttgccg agcctgctct ctatctgccc tcaatgagac
ctaggcccaa tgcagactct 118620aaaggttgca cagtccgctc tctatctgtc ctcaatgaga
cctaggccca atagagactc 118680taaaggttgc acagtctgct ctctatctgt cctgaatgag
acccaggccc aatgcagact 118740ctaaacgttg catagtctgc tctctatctg tccgcaatta
gacctaggcc caatgcagac 118800tctaaaggtt gcacagtctg ctgtctatct gacctcaagg
agacctaggc ccaatgcaga 118860ctctaaaggt tgcacagtct ggtctctttc tgtcctcaat
gacacctagg cccagtgcag 118920actctaaagt ttgcacagtc tgctctctgt ctgtcctcaa
agagacctag gcccagtgca 118980gactctaaag gttgcacagt ctgctctcta tctgtcctca
atgagaccta ggcccaatgc 119040agactctaaa ggttgcacag tttgctctct atctgccctc
aatgagacct aggtccaatg 119100caaactctaa agtttgcaca gtctggtctc tatctgtcct
caatgagacc taggcccaat 119160gccgactcta gaggttgcac agtgtgctct ctatctgctc
tcaatgagac ctatgcccaa 119220tgcagactct aaaggttgcg cagtctgctc tctaaatgcc
ctcaatgaga cctaggccca 119280atgcagactc tagaggttgc acagtctgct ctctatctgt
cctcaatgag acctaggccc 119340agtgcagact ctaaaggttg ctcagtctgc tctctatctg
tcctcaatga gacccaggca 119400caatgcagac tctaaaggtt gcacagtctg ctctatatct
gtcctcaatg agacctagga 119460ccagtgccga ctctaatggt tgcctagtct gctctctatc
tgtcctgaat gagacctagg 119520cccaatgccg actctaaagg ttgcacagta tgctctctat
ctgctctcaa tgagacctag 119580gcccaatgca gactctaaag gttgcacagt ctgctctcta
tctgtcctca atgagaccta 119640ggcccagtgc agactctaaa ggttgcacag tctgctctct
atctgccctc aatgagacct 119700aggcccaatg cagactctaa agtttgcaca gtctggtctc
tatctgtcct caatgagacc 119760caggcccaat gcagactgta aaggttgcac agtctgctct
atatgtgtcc tcaatgagac 119820ctaggcccag tgccgactct aaaggttgcc tagtctgctc
tctatctgtc ctcaatgaga 119880cctaggtcca atgcagtccc taaaggttgc acagtctgct
ctctatttgt cctcagtgag 119940acccaggccc aatgcagact ctaaaggttg cacagtctgc
tctccatcgg tcctcaatga 120000gaccgaggcc caattcggac tctaaaggtt gcacagtctg
ctctctatct gtcttcaatg 120060agacctaggc ccaatgcaga ctctaaagtt tgcacagtct
gctctctgtc tgccctcaat 120120gagccctaga cccaatgcag actctaaagg ttgcacagtc
tgctctctat ctgtcctcaa 120180tgagacctag gcccaatgca gactctaaag gttgcacagt
ctgctctcta actgccctca 120240atgagaccta ggcccaatgc agactctaat ggttgcacag
tctgctctct atctgtcctc 120300aatgagactc aggctcaatg cagtctctaa aggttgcaca
gtctgctctc tatctgtcct 120360caatgagacc taggcccaat gcagactcta aaggttgcac
cgtctgctct ctatctgccc 120420tcaatgagac ctaggcccaa tgcagactct aaaggttgta
cagtcggctc tctacctgcc 120480ctcattgaga cctaggccca atgcagactg taaaggttgc
accgtctgtt ctctatctgc 120540cctcaatgag acgtaggccc aatgcagact ctaaaggttg
tgcagtctgc tctctatgtg 120600ccctcaatga gacctaggcc caatgcagac tctaaaggtt
gcacagtctg ctctctatct 120660gtcctcaatg agacccaggc tcaatgcagt ctctaaaggt
tgcacagtgt gctctctatc 120720tgacctcaat gagaccttgg cccaatgcag actctaaagg
ttgcacagtc ggctctctac 120780ctgccctcaa tgagacctag gcccaatgca gattctaaag
gttgcacagt ctgctctcta 120840tcggtcctca atgagaccga ggctctatgc agactctaaa
ggttacacag tgtgctctct 120900atctgtcctc aatgagaccc agacccaatg cagactctaa
agtttgcgca gtctgctctc 120960tatctgtcct caatgagacc tagggccagt gcagactcta
aagttgcata gtctgctctc 121020tatcagtcct cagtgagacc tagacctaat gcagactcta
aagtttgcaa agtctgctct 121080ctatctctcc tcagtgagac ctagacccaa tgcagactct
aaagtttgca cagtatggtc 121140tctatatgcc ctcaatgaga cctaggccca gtgcagactc
gaaaggttgc acagtctgct 121200ctctatctgt cctcaatgag acctaggctc aatgcagact
ctaaaggttg cacagtctgc 121260cctctatctg tcctcaatga gacctaggcc caatgcagac
tctaaagttt gcacagtctg 121320gtctctatct gtcctcaatg agacctaggc ccaatgccga
ctctagaggt tgcacagtgt 121380gctctctatc tgctctcaat gagacctagg cccaatgcag
actctaaagg ttgcacagtc 121440tgctctctaa ctgccctcaa tgagacctag gcccaatgca
gactctaaag gttgcacagt 121500ctgttctcta tctgtcctca atgagaccta ggccaagtgc
agactctaaa gcttgcacag 121560tctgctctct atctgacctc aaagagacct aggcccaatg
cagactataa aggttctaca 121620gtctgctctc tatctgtcct caatgagacc taggcccaat
gcagactcta aagtttgcgc 121680actctggtct ctttctgtcc tcaatgagac ctaggccaaa
tgcagactgt aaaggttgca 121740cagcctgctc tctaactgtc ctcaatgaga cataggccca
atgcagactc taaaggttgc 121800acagtctgct ctctatgtgt cctcaatgag acctaggccc
agtgcagact ctaaaggttg 121860catagtatgc tctctatctg tcctcaatga gatctaggcc
caatgcagac tctaagggtt 121920cccgagcctg ctctctatct gccctcaatg agacctaggc
ccaatgcaga ctctaaaggt 121980tgcacagtcc tctccctatc tgtcctcaat gagacctagg
cccaatagag actctaaagg 122040ttgcacagtc tgctctctat ctgtcctcaa tgagacccag
gcccaatgca gactctaaac 122100gttgcatagt ctgctctcta tctgtccgca attagaccta
ggcccaatgc agactctaaa 122160cgttgcacag tctgctgtct atctgtccgc aattagacct
aggcccaatg cagactctaa 122220aggttgcaga ttctgctgtc tatctgacct caaggagacc
taggcccaat gcagactcta 122280aaggttgcac agtctggtct ctatctgtcc tcaatgacac
ctaggcccag tgcagactct 122340aaagtttgca cagtctgctc tctgtctgtc ctcaaagaga
cctaggccca gtgcagactc 122400taaaggttgc acagtctcct ctctatctgt cctcactgat
acctaggccc aatgcagact 122460ctaaaggttg cacagtctgt tctctatttg tcctcaatga
gacccaggcc caatgcagag 122520tctaaaggtt gcacagtctg ctctctatcg gtcctcaatg
agacctaggc ccaatgcaga 122580ctctaaaggt tgcacagtct gctctctatc tgccctcaat
gagacctagg cccaatgcaa 122640actctaaagg ttgcacagtc tggtctctat ctgtcctcaa
tgagacctag gcccaatgcg 122700gactctaaag gttgcacagt gtgctctcca tctgtcctca
atgagaccta ggccaaatgc 122760agactctaaa ggttgcacag tctgctctct atgtgtcctc
aatcagacct aggcccagtg 122820cagactctaa agtttgcaca gtctgctctc tatcggccct
caatgagacc taggcccaat 122880gcagactgta aaggttgcac agtctgctct ctatctgctc
tcaagagacc taggcccaat 122940gcaaactcta aaggttgcac attctggtct ctatctctcc
tgaatgagac ccaggcccaa 123000tgcagactgt aaaggttgca cagtctgctc tctatctgtc
ctcaatgaga cctaggccca 123060gtgcagactg taaagtttgc atagtctgct ctctatctgt
cctcagtgag acctaggtcc 123120aatgcagact ctaaatgttg cacagtctgc tctctatctg
tcctcgatga gacctagccc 123180tagtgcagac tctaaaggtt gcacagtctg ctctctatct
gccctcaatg agacctaggc 123240ccaatgcaga ctctaaaggt tgcacagtcg gctctccatt
tttcctcaat gagacccagg 123300cccaatgcag actctaaagg ttgcacagtc tgctctctat
cggtcctcaa tgagaccgag 123360gccctatgca aactctaaag gttacacagt gtgctctcta
tctgtcctca gtgagaccta 123420ggcccaatgc agactctaaa gtttgcgcag tctgctctct
atctgtcctc aatgagacct 123480agggccaggc agactctaaa gttgcatagt ctgctctcta
tcagtcctca gtgagaccta 123540gacctaatgc agactctgaa gtttgcaaag tctgctctct
atctctcctc agtgagacct 123600agacccaatg cagactctaa agtttgcaca gtatggtctc
tatatgccct caatgagacc 123660taggcccagt gcagactcta aagtttgcaa agtctgctct
ctatctgtcc tcaatgagac 123720ctaggcccaa tgcagactct aaaggttgca cagtctgccc
tctatctgtc ctcaatgaga 123780cctaggccca atgcagactc taaagtttgc acagtctggt
ctctatctgt cctcaatgag 123840acctaggccc aatgccgact ctagagtttg cacagtgtgc
tctctatctg ctctcaatga 123900gacctaggcc caatgcagac tctaaagttt gcacagtctg
ctctctaact gccctcaatg 123960agacctaggc ccaatgcaga ctctaaaggt tgcacagtct
gttctctatc tgtcctcaat 124020gagacctagg acaagtgcag actctaaagc ttgcacagtc
tgctctctat ctgacctcaa 124080tgagacctag gcccaatgca gactataaag gttctacagt
ctgctctcta tctgtcctca 124140atgagaccta ggcccaatgc agactctaaa gtttgcacac
tctggtctct ttctgtcctc 124200aatgagacct aggccaaatg cagactctaa aggttgcaca
gtctgctctc taactgtcct 124260caatgagaca taggcccaat gcagactcta aaggttgcac
agtctgctct ctatgtgtcc 124320tcaatgagac ctaggcccag tgcagactct aaaggttgca
tagcatgctc tctatctgtc 124380ctcaatgata tctaggccca atgcagactc taagggttgc
cgagcctgct ctctatctgc 124440cctcaatgag acctaggccc aatgcagact ctaaaggttg
cacagtccgc tccctatctg 124500tcctcaatga gacctaggcc caatagagac cctaaaggtt
gcacagtctg ctctctatct 124560gtcctcaatg agacccaggc ccaatgcaga ctctaaacgt
tgcatagtct gctctctatc 124620tgtccgcaat tagacctagg cccaatgcag actctaaacg
ttgcacagtc tgctgtctat 124680ctgtccgcaa ttagacctag gcccaatgca gactctaaag
gttgcagagt ctgctgtctg 124740tctgacctca aggagaccta ggcccaatgc agactctaaa
ggttgcacag tctggtctct 124800atctgtcctc aatgacacct aggcccagtg cagactctaa
agtttgcaca ttctgctctc 124860tgtctgtcct caaagagacc tagggccagt gcagactcta
aaggttgcac agtctcctct 124920ctatttgtcc tcactgatac ctaggcccat tgtagactct
aaaggttgca cagtctgccc 124980tctatctgtc atcaatgaga cctaggccca atgcagactc
taaagtttca acagtctggt 125040ctctatctgt cctcaatgag acctaggccc aatgccgact
ctagaggttg cacagtgtgc 125100tctctatctg ctctcaatga gacctaggcc caatgcagac
tctaaaggtt gcacagtctg 125160ctctctaact gccctcaatg agacctaagc ccaatgcaga
ctctaaaggt tgcacagtct 125220ggtcgctatc tgtcctcaat gagacccagg cccaatgcag
actctaaagg ttgcacagtc 125280tgctctatat ctgtcctcaa tgagacctag gaccagtgcc
gactctaatg gttgcctagt 125340ctgctctcta tctgtcctca atgagacgta ggcccaatgc
agactctaaa ggttgcacag 125400tccggtctct atctgtcctc aatgagacct aggcccaatg
ccgactctaa agtttgcaca 125460gtgtgctctc tatctgctct caatgagacc taggcccagt
gcagactcta aaggttgcac 125520agtctgctct gtatcggtcc ataatgagac ctaggcccaa
tgcagactct aaaggttgca 125580cagtctgccc tctatctgtc ctcaatgaga cctaggccca
atgcagactc taaagtttgc 125640acagtctggt ctctatctgt cctcaatgag acctaggccc
aatgccgact ctagaggttg 125700cacagtgtgc tctctatctg ctctcaatga gacctaggcc
caatgcagac tctaaaggtt 125760gcgcagtctg ctctctaaat gccctcaatg agacctaggc
ccaatgcaga ctctagaggt 125820tgcacagtct gctctctatc tgtcctcaat gagacctagg
cccagtgcag actctaaagg 125880ttgcacagtc tgctctctat ctgtcctcaa tgagacccag
gcacaatgca gactctaaag 125940gttgcacagt ctgctctata tctgtcctca atgagaccta
ggaccagtgc cgactctaat 126000ggttgcctag tctgctctct atctgtcctc aatgagacct
aggcccaatg cagactctaa 126060aggttgcaca gtctggtctc tatctgtcct caatgagacc
taggcccaat gccgactcta 126120aaggttgcac agtatgctct ctatctgctc tcaatgagac
ctaggcccaa tgcagactct 126180aaaggttgca cagtctgctc tctatctgtc ctcaatgaga
cctaggccca gtgcagactc 126240taaaggttgc acagtctgct ctctatctgc cctcaatgag
acctaggccc aatgcagact 126300ctaaaggttg cacagtctgg tctctatctg tcctcaatga
gacccaggcc caatgcagac 126360tgtaaaggtt gcacagtctg ctctatatgt gtcctcaatg
agacctaggc ccagtgccga 126420ctctaaaggt tgcctagtct gctctctatc tgtcctcaat
gagacctagg tccaatgcag 126480tccctaaagg ttgcacagtc tgctctctat ttgtcctcag
tgagacccag gcccaatgca 126540gactctaaag gttgcacagt ctgctctcca tcggtcctca
atgagaccga ggcccaattc 126600ggactctaaa ggttgcacag tctgctctct atctgtcttc
aatgagacct aggcccaatg 126660cagactctaa agtttgcaca gtctgctctc tgtctgccct
caatgagccc tagacccaat 126720gcagactcta aaggttgcac agtctgctct ctatctgtcc
tcaatgagac ctaggcccaa 126780tgcagactct aaaggttgca cagtctgctc tctatgtgcc
ctcaatgaga cctaggccca 126840atgcagactc taatggttgc acagtctgct ctctatctgt
cctcaatgag actcaggctc 126900aatgcagtct ctaaaggttg cacagtctgc tctctatctg
tcctcaatga gacctaggcc 126960caatgcagac tctaaaggtt gcaccgtctg ctctctatct
gccctcaatg agacctaggc 127020ccaatgcaga ctctaaaggt tgtacagtcg gctctctacc
tgccctcatt gagacctagg 127080cccaatgcag actgtaaagg ttgcaccgtc tgttctctat
ctgccctcaa tgagacgtag 127140gcccaatgca gactctaaag gttgtgcagt ctgctctcta
tgtgccctca atgagaccta 127200ggcccaatgc agactctaaa ggttgcacag tctgctctct
atctgtcctc aatgagaccc 127260aggctcaatg cagtctctaa aggttgcaca gtgtgctctc
tatctgacct caatgagacc 127320ttggcccaat gcagactcta aaggttgcac agtcggctct
ctacctgccc tcaatgagac 127380ctaggcccaa tgcagattct aaaggttgca cagtctgctc
tctatcggtc ctcaatgaga 127440ccgaggctct atgcagactc taaaggttac acagtgtgct
ctctatctgt cctcaatgag 127500acctagaccc aatgcagact ctaaagtttg cgcagtctgc
tctctatctg tcctcaatga 127560gacctagggc cagtgcagac tctaaagttg catagtctgc
tctctatcag tcctcagtga 127620gacctagacc taatgcagac tctaaagttt gcaaagtctg
ctctctatct ctcctcagtg 127680agacctagac ccaatgcaga ctctaaagtt tgcacagtat
ggtctctata tgccctcaat 127740gagacctagg cccagtgcag actcgaaagg ttgcacagtc
tgctctctat ctgtcctcaa 127800tgagacctag gctcaatgca gactctaaag gttgcacagt
ctgccctcta tctgtcctca 127860atgagaccta ggcccaatgc agactctaaa gtttgcacag
tctggtctct atctgtcctc 127920aatgagacct aggcccaatg ccgactctag aggttgcaca
gtgtgctctc tatctgctct 127980caatgagacc taggcccaat gcagactcta aaggttgcac
agtctgctct ctaactgccc 128040tcaatgagac ctaggcccaa tgcagactct aaaggttgca
cagtctgttc tctatctgtc 128100ctcaatgaga cctaggccaa gtgcagactc taaagcttgc
acagtctgct ctctatctga 128160cctcaatgag acctaggccc aatgcagact ataaaggttc
tacagtctgc tctctatctg 128220tcctcaatga gacctaggcc caatgcagac tctaaagttt
gcgcactctg gtctctttct 128280gtcctcaatg agacctaggc caaatgcaga ctgtaaaggt
tgcacagcct gctctctaac 128340tgtcctcaat gagacatagg cccaatgcag actctaaagg
ttgcacagtc tgctctctat 128400gtgtcctcaa tgagacctag gcccagtgca gactctaaag
gttgcatagt atgctctcta 128460tctgtcctca atgagatcta ggcccaatgc agactctaag
ggttcccgag cctgctctct 128520atctgccctc aatgagacct aggcccaatg cagactctaa
aggttgcaca gtcctctccc 128580tatctgtcct caatgagacc taggcccaat agagactcta
aaggttgcac agtctgctct 128640ctatctgtcc tcaatgagac ccaggcccaa tgcagactct
aaacgttgca tagtctgctc 128700tctatctgtc cgcaattaga cctaggccca atgcagactc
taaacgttgc acagtctgct 128760gtctatctgt ccgcaattag acctaggccc aatgcagact
ctaaaggttg cagattctgc 128820tgtctatctg acctcaagga gacctaggcc caatgcagac
tctaaaggtt gcacagtctg 128880gtctctatct gtcctcaatg acacctaggc ccagtgcaga
ctctaaagtt tgcacagtct 128940gctctctgtc tgtcctcaaa gagacctagg cccagtgcag
actctaaagg ttgcacagtc 129000tcctctctat ctgtcctcac tgatacctag gcccaatgca
gactctaaag gttgcacagt 129060ctgttctcta tttgtcctca atgagaccca ggcccaatgc
agagtctaaa ggttgcacag 129120tctgctctct atcggtcctc aatgagacct aggcccaatg
cagactctaa aggttgcaca 129180gtctgctctc tatctgccct caatgagacc taggcccaat
gcaaactcta aaggttgcac 129240agtctggtct ctatctgtcc tcaatgagac ctaggcccaa
tgcggactct aaaggttgca 129300cagtgtgctc tccatctgtc ctcaatgaga cctaggccaa
atgcagactc taaaggttgc 129360acagtctgct ctctatgtgt cctcaatcag acctaggccc
agtgcagact ctaaagtttc 129420cacagtctgc tctctatcgg ccctcaatga gacctaggcc
caatgcagac tgtaaaggtt 129480gcacagtctg ctctctatct gctctcaaga gacctaggcc
caatgcaaac tctaaaggtt 129540gcacattctg gtctctatct ctcctgaatg agacccaggc
ccaatgcaga ctgtaaaggt 129600tgcacagtct gctctctatc tgtcctcaat gagacctagg
cccagtgcag actgtaaagt 129660ttgcatagtc tgctctctat ctgtcctcag tgagacctag
gtccaatgca gactctaaat 129720gttgcacagt ctgctctcta tctgtcctcg atgagaccta
gccctagtgc agactctaaa 129780ggttgcacag tctgctctct atctgccctc aatgagacct
aggcccaatg cagactctaa 129840aggttgcaca gtctgctctc tgtttttcct caatgagacc
caggcccaat gcagactcta 129900aaggttgcac agtctgctct ctatcggtcc tcaatgagac
cgaggccctt tgcaaactct 129960aaaggttaca cagtgtgctc tctatctgtc ctcagtgaga
cctaggccca atgcagactc 130020taaagtttgc gcagtctgct ctctatctgt cctcaatgag
acctagggcc aggcagactc 130080taaagttgca tagtctgctc tctatcagtc ctcagtgaga
cctagaccta atgcagactc 130140tgaagtttgc aaagtctgct ctctatctct cctcagtgag
acctagaccc aatgcagact 130200ctaaagtttg cacagtatgg tctctatatg ccctcaatga
gacctaggcc cagtgcagac 130260tctaaagttt gcaaagtctg ctctctatct gtcctcaatg
agacctaggc ccaatgcaga 130320ctctaaaggt tgcacagtct gccctctatc tgtcctcaat
gagacctagg cccaatgcag 130380actctaaagt ttgcacagtc tggtctctat ctgtcctcaa
tgagacctag gcccaatgcc 130440gactctagag tttgcacagt gtgctctcta tctgctctca
atgagaccta ggcccaatgc 130500agactctaaa gtttgcacag tctgctctct aactgccctc
aatgagacct aggcccaatg 130560cagactctaa aggttgcaca gtctgttctc tatctgtcct
caatgagacc taggacaagt 130620gcagactcta aagcttgcac agtctgctct ctatctgacc
tcaatgagac ctaggcccaa 130680tgcagactat aaaggttcta cagtctgctc tctatctgtc
ctcaatgaga cctaggccca 130740atgcagactc taaagtttgc acactctggt ctctttctgt
cctcaatgag acctaggcca 130800aatgcagact ctaaaggttg cacagtctgc tctctaactg
tcctcaatga gacataggcc 130860caatgcagac tctaaaggtt gcacagtctg ctctctatgt
gtcctcaatg agacctaggc 130920ccagtgcaga ctctaaaggt tgcatagcat gctctctatc
tgtcctcaat gatatctagg 130980cccaatgcag actctaaggg ttgccgagcc tgctctctat
ctgccctcaa tgagacctag 131040gcccaatgca gactctaaag gttgcacagt ccgctcccta
tctgtcctca atgagaccta 131100ggcccaatag agaccctaaa ggttgcacag tctgctctct
atctgtcctc aatgagaccc 131160aggcccaatg cagactctaa acgttgcata gtctgctctc
tatctgtccg caattagacc 131220taggcccaat gcagactcta aacgttgcac agtctgctgt
ctatctgtcc gcaattagac 131280ctaggcccaa tgcagactct aaaggttgca gagtctgctg
tctgtctgac ctcaaggaga 131340cctaggccca atgcagactc taaaggttgc acagtctggt
ctctatctgt cctcaatgag 131400acctaggccc agtgcagact ctaaagtttg cacattctgc
tctctgtctg tcctcaaaga 131460gacctagggc cagtgcagac tctaaaggtt gcacagtctc
ctctctattt gtcctcactg 131520atacctaggc ccattgtaga ctctaaaggt tgcacagtct
gccctctatc tgtcctcaat 131580gagacctagg cccaatgcag actctaaagt ttcaacagtc
tggtctctat ctgtcctcaa 131640tgagacctag gcccaatgcc gactctagag gttgcacagt
gtgctctcta tctgctctca 131700atgagaccta ggcccaatgc agactctaaa ggttgcacag
tctgctctct aactgccctc 131760aatgagacct aagcccaatg cagactctaa aggttgcaca
gtctggtcgc tatctgtcct 131820caatgagacc caggcccaat gcagactcta aaggttgcac
agtctgctct atatctgtcc 131880tcaatgagac ctaggaccag tgccgactct aatggttgcc
tagtctgctc tctatctgtc 131940ctcaatgaga cgtaggccca atgcagactc taaaggttgc
acagtccggt ctctatctgt 132000cctcaatgag acctaggccc aatgccgact ctaaagttgg
cacagtgtgc tctctatctg 132060ctctcaatga gacctaggcc caatgcagac tctaaaggtt
gcacagtctg ctctctaact 132120gccctcaatg agacctaggc ccaatgcaga ctctaaacgt
tgcatagtct ggtctctatc 132180tgccctcaat gagacctagg cccaatgcag actctagagt
ttgcacagtc tgctctctat 132240ctgtcctcaa tgagacctag gccaagtgca gactctaaag
cttgcacagt ctgctctcta 132300tctgacctca atgagaccta ggcccaatgc agactataaa
gtttctacag tctgctctct 132360atctgtcctc aatgagacct aggcccaatg ctgactctaa
aggttgcaca ctctggtctg 132420tttctgtcct caatgagacc taggccaaat gcagactcta
aagcttgcac agtctgctct 132480ctaactgtcc tcaatgagac ataggcccaa tgcagactct
aaaggttgca cagtctgctc 132540tctatgtgtc ctcaatgaga cctaggccca atgcagactc
taaaggttgc atagtatgct 132600ctctatctgt cctcaataag atctaggccc aatgcagact
ctaagggttg ccgagcctgc 132660tctctatctg ccctcaatga gacctaggcc caatgcagac
tctaaaggtt gcacagtccg 132720ctctctatct gtcctcaatg agacctaggc ccaatagaga
ctctaaaggt tgcacagtct 132780gctctctatc tgtcctgaat gagacccagg cccaatgcag
actctaaacg ttgcatagtc 132840tgctctctat ctgtccgcaa ttagacctag gcccaatgca
gactctaaag gttgcacagt 132900ctgctgtcta tctgacctca aggagaccta ggcccaatgc
agactctaaa ggttgcacag 132960tctggtctct ttctgtcctc aatgacacct aggcccagtg
cagactctaa agtttgcaca 133020gtctgctctc tgtctgtcct caaagagacc taggcccagt
gcagactcta aaggttgcac 133080agtctgctct ctatctgtcc tcaatgagac ctaggcccaa
tgcagactct aaaggttgca 133140cagtttgctc tctatctgcc ctcaatgaga cctaggtcca
atgcaaactc taaaggttgc 133200acagtctggt ctctatctgt cttcaatgag acccaggccc
aatgcagact ctaaagattg 133260cacagtctgc tctctatcgg tcctcaatga gaccgaggcc
ctatgcagac tctaaaggtt 133320acacagtgtg ctctctatct gccctcaatg agacctaggc
ccagtgcaga ctctaaaggt 133380tgcacagtct gctctgtatc ggtccacaat gagacctagg
cccaatgcag actctaaagg 133440ttgcacagtc tgccctctat ctgtcctcaa tgagacctag
gcccaatgca gactctaaag 133500tttgcacagt ctggtctcta tctgtcctca atgagaccta
ggcccaatgc cgactctagt 133560ggttgcacag tgtgctctct atctgctctc aatgagacct
aggcccaatg cagactctaa 133620aggttgcgca gtctgctctc taaatgccct caatgagacc
taggcccaat gcagactcta 133680gaggttgcac agtctgctct ctatctgtcc tcaatgagac
ctaggcccag tgcagactct 133740aaaggttgca cagtctgctc tctatctgtc ctcaatgaga
cccaggcaca atgcagactc 133800taaaggttgc acagtctgct ctatatctgt cctcaatgag
acctaggacc agtgccgact 133860ctaatggttg cctagtctgc tctctatctg tcctcaatga
gacctaggcc caatgcagac 133920tctaaaggtt gcacagtctg gtctctatct gtcctcaatg
agacctaggc ccaatgccga 133980ctctaaaggt tgcacagtat gctctctatc tgctctcaat
gagacctagg cccaatgcag 134040actctaaagg ttgcacagtc tgctctctat ctgtcctcaa
tgagacctag gcccagtgca 134100gactctaaag gttgcacagt ctgctctcta tctgccctca
atgagaccta ggcccaatgc 134160agactctaaa ggttgcacag tctggtctct atctgtcctc
aatgagaccc aggcccaatg 134220cagactgtaa aggttgcaca gtctgctcta tatgtgtcct
caatgagacc taggcccagt 134280gccgactcta aaggttgcct agtctgctct ctatctgtcc
tcaatgagac ctaggtccaa 134340tgcagtccct aaaggttgca cagtctgctc tctatttgtc
ctcagtgaga cccaggccca 134400atgcagactc taaaggttgc acagtctgct ctccatcggt
cctcaatgag accgaggccc 134460aattcggact ctaaaggttg cacagtctgc tctctatctg
tcttcaatga gacctaggcc 134520caatgctgac tctaaagttt gcacagtctg ctctctgtct
gccctcagtg ggccctagac 134580ccaatgcaga ctctaaaggt tgcacagtct gctctctatc
tgtcctcaat gagacctagg 134640cccaatgcag actctaaagg ttgcacagtc tgctctctat
gtgccctcaa tgagacctag 134700gcccaatgca gactctaatg gttgcacagt ctgctctcta
tctgtcctca atgagactca 134760ggctcaatgc agtctctaaa ggttgcacag tctgctctct
atctgtcctc aatgagacct 134820aggcccaatg cagactctaa aggttgcacc gtctgctctc
tatctgccct caatgagacc 134880taggcccaat gcagactcta aaggttgtac agtcggctct
ctacctgccc tcaatgagac 134940ctaggcccaa tgcagactgt aaaggttgca ccgtctgttc
tctatctgcc ctcaatgaga 135000cgtaggccca atgcagactc taaaggttgc acagtctgct
ctctatctgt cctcaatgag 135060acccaggctc aatgcagtct ctaaaggttg cacagtgtgc
tctctatctg acctcaatga 135120gaccttggcc caatgcagac tctaaaggtt gcacagtcgg
ctctctacct gccctcaatg 135180agacctaggc ccaatgcaga ttctaaaggt tgcacagtct
ggtctctatc tgcccttaat 135240gagacctaca ctcccaggag tctgcagaac agggtgtgtg
taagttttct ggggccgctc 135300aaggaaacgg gggattaaaa aatattatcc tcacagtgct
ggcatgttgg cctacacaga 135360gccctgctcg ccgtgaacgt caggacttcc tgcgtgatct
cttcaagtcc gattgggagc 135420cctttgactc gtcccctgtc tgtgctggag aattcagagc
ccactgactc atctttcttt 135480gtggcctggg agagttgtgg agaacatgct gtaccttcgc
ggtgccgcac ggatcttcct 135540gctccctccc tcgggagtct cgcagggacc ccatctcgtt
ttaatgtttt gtcaatacgg 135600cacccacgag aacgttgcag ggaagacacc actgtggccg
taaaccacag aaactagagc 135660tgaagtggcc ccaggtggcc tccagtcaag cagtatccaa
attcttcacc ctgaggccct 135720ttatttatta ttattattat tagagacgga gtttcgctct
tgttacccag gctggagtgc 135780aatggtgtga tatcagctca ccgcaacctc cgcctcccgg
gttcaagcaa ttctctggcc 135840tcagcctccc aagtagctgg gattacaggt gggcgccacc
acgcctggct aattttttgt 135900atttttagag atggggattc tctatgttgg tcaggctggt
ctcgaactcc caacctcagg 135960tgagctgctg gccttggcct cccaaagtgc tgggattaca
ggcgtgcacc accacaccca 136020gccctatctt attctttttc tctcaccagg gaccccaaat
ttggaagaac cataatcatg 136080tttattgaca ttatgttaaa ttaaggttcc cacgtttatt
aataaaagaa atatatcatt 136140agcctggcct tttaaatttt tcttaattta attttttttt
ttttttgagg cagggtctca 136200ctctgtcacc caggctggag tgcaatggta ccatcatggc
tcaccacagc cccccgctcc 136260taggctcaag caatcctctt gcctcagcct cctgagtatc
tggggattat aggtgcacac 136320catcacactc agccaattaa aaaaaaattt ctagtagaga
tggggtctca ccaagttgtc 136380caggctggtc tcacacttct gagctcaagt aatcgtcctg
ctttggcctc ccaaagtgct 136440cggattacag gggtaagcta ccacattcag cctttatttt
tatttttaat ggaggtaaaa 136500gccacataac ataaaattta ccctttcaac tacttctttt
ttttagatgg aggcttgctc 136560tgttgcccag gctggagtgc agtggcacaa tctcagctca
cttcaacctc tacctcccgg 136620gttcaagtga ttcccctgcc tcagcctccc aagtagctgg
gatcacaggc acccgccacc 136680acacctggca aattttttgt attttagtag agacggggtt
tcactgtgtt ggccaagacg 136740gtgtcgatct cctgacctcg tgatccgcct gcctcggcct
cccaaagtgc tgggattaca 136800ggcatgagcc accgcgcccg gcccctttaa agtattttta
aggatacact tcagcagtgt 136860tcatcatatc cgcattgttg tataacagat gtttacaact
tcttcatctt acaaaacaga 136920aactgtgtcc acatcaaacc agggtgcccc attcccccgg
cccctggcac ccaccattct 136980actgtctgtc tctatgaatt ccactcttcc agagacctca
taggagtggg atcacacagc 137040acttttttgt ctggcttatc ttgttaacaa caggtgagtc
catgtggtag cctgtctcat 137100cattccttcc tttttagggc tgattcatat ttcattatat
ggatgaacca cattttcttt 137160ttccagtcat gctgtaacag gatgagtcac agtcaaaact
cctcagacac cagattaaag 137220aaggaagagg tttttttatt tggccgggag attcggcaga
ctcgtgtctt aagagccgag 137280ctccccgaaa aagaaattcc tagccctttt aagggctaag
aactctaagg ggtctatgtg 137340aaagagtcat aatagatcaa gtaagtgtga ggaacgtgag
tgggggctac atacatcagc 137400taagagaaca aaaagttttt atttttttat tttttttgag
acggaatctc gctctgtggc 137460ccaggctgga gtgcagtggc gtgatctcag ctcactgcaa
gctccgcctc ccgggttcac 137520accattctcc tgcctcagcc tccccagtag ctgggactac
aggcgcccgc caccgcgccc 137580ggctaatttt ttgtattttt agtagacacg gggtttcatc
atgttaacca ggatggtctc 137640gatctcctga ccttgtgatc cacccgcctc ggcctcccaa
agtgctggga ttagaggctg 137700gagccaccgt gcccggcctg cacccagcta attttttgta
tttttagtag agatggggtt 137760tcaccgtgtt agccaggatg gtctcaatct cctgacctca
tgatcctccc acctcggcct 137820cccaaagtcc tgggattaca ggcgtgagcc accgcgcccg
gccagaacaa aaagttttac 137880agtgctttct catacaatgt ctggaattta cagatagcac
cagtagtttt ggtcagcggt 137940taatactatt attattttaa tcaccagggc caggtggtgg
caccaaggtc gtctagctat 138000ttatcttact tttgtttctt tccaactttt tgctttctct
cttttctctt gtcttataaa 138060ctagggaaaa ggggaggttg gggagaaagt gggaaggaca
acaggagaag tggtggtgtc 138120ataacataat gcgatcatgg gcaccgggct gcttccatct
tttggctatt gtgaatactg 138180ctgtaacgac cacggttgtg caataatccc ttccagactc
tgctttcaat ctttttggat 138240ttagtcggag aagtaatgtg attgctggtt cataggtggt
tccatttctg gttatttatt 138300tattttttaa gagacagagt tttatatgtt gcccaggctg
gccttgaact cctgggcttc 138360agtgatcccc ttccctcagc ctcccaagta gccggtagtg
cagctgcaca tcaccacacc 138420caagtgattt ttagttgtta tttttctggt tttgtttttg
cggagatgga gtttcactgt 138480gccgcccagg gtggagtgcg gtggcataat cggctcactg
cagcctccac ctcctggttc 138540aggcgcttct cctgccttag cctcccgagt agctgggact
ataggcatct gtcaccacac 138600ttagctaatt attttgtgtt tgcttccccc caccccgccc
ccccgagatg gagtcttcct 138660ttgtcaccca ggctggagtg cagtggcgcg atctcggctc
aatgcaacct ctgcctccgg 138720ggttcaagca attctcctgc ctcagcctcc cgggtagctg
ggattcctgg cacccacaac 138780cacgcccggc taatttttta tttttagtag agacggagtt
tcaccatgtt ggccaggctg 138840gtctcgaact cctgactttg tgatccacct gcctcgggct
cccaaagtgc tgggatgaca 138900ggtgtgagcc actgtgccca gcctgatatt tagtgctttt
ttgaggaggc tccatagtgt 138960tttccacggt ggccacacca ttttctagtc ctacaggcaa
tccacgaggg ctccaatttc 139020cacacatcct tgttaacact atttttgttt cactgtagca
tttcatggat gtgaggtgct 139080atcactgtgg ttttgatgtg tatttctcta atgattactg
atgttgagga tccttccatg 139140tttgtttgct acttgtatat cttttctgga gaaatatcta
ttcaggtcgt ttgctcattt 139200ttcaatcagt taacttgttt ttcaattgtt cagttgcagg
agctctttat atgtgctgga 139260cgaatatccg acgtaccaga catataatct gcagttattt
cctcttattc catgtcttgc 139320cttttcactg ttgtttcctg tgcagaaatg tttaacctcg
aagttggacc atttgtctat 139380ttgtgctttt gttgcctgtg cttatctggg ctttggatag
gccagaggta aacggcaggt 139440gttactgcac caagttcata aaatcgagcc caaaacaaag
gagtcgacac agtaattagc 139500tggtgtgtcg ccttggcgag aatatatatg acttttgctg
agaattttca ttaatgttta 139560ttttctattt ttattttttg agatggagtc tcgctctgtc
gcccaggccg gagtgcagtg 139620gcgcaatctc agctcactgc aagctccacc tcccgggctc
acgctgttct cctgcctcag 139680cctcctgagt agctgggact acaggcgccc gccaccgcgc
ccggagaatt ttttgtattt 139740ttagtagaga tggggtttca ctgtgttggc caggatggtc
ttgatctcct gacctcgtga 139800tccacctgcc ttggcctccc aaagtgctgg gattacaggc
gtgagccacc gcgcccggcc 139860attaatgttt attttgacgc aacttcacag ttacattaag
gcaacaatat ggcgcaaaga 139920attccttcgt atcaggcatt cacattcccc aaacgctggc
ggtctacaac agcttcatcc 139980tggatcagaa ccaagtggag ggactgctgt ttctgtgggc
tggtttcctg ggggctgcca 140040taaccagtga ccagaaaccg ggtgggttcg tcaacaggaa
tttatcatct cccagtctcg 140100gatgtcgatg ttgaagccct aacccccact gcctcagaac
gtgagtgtat ttggcctcat 140160agtattagaa cgaggctgtc agggtgggcc ctaaagcaac
ctgctgttct catgagagga 140220agtgtggaca cacacagaag agacgatagg gatacttgtg
cacagtgaaa agaccctatg 140280agcgtacacc agacggcgtc cgcaagccga ggagaggaga
aaccagccct gctgacaaca 140340ccttgctctc ggacctcagc ctccaggtct gtgggaagat
aattttcagt gaagccctcc 140400agtcttggta ccttatggcg gccctgaaca ctcatacaga
cgggtacatt tactgtccct 140460gttcttctgc cgaggaaatg gaggcacaga gacgtttagt
gaacttgacc catgtgggag 140520ggccaggagc ggtcaaggtt ggattggaac aaaccaccct
ttttgcagca ctcacgttct 140580taggcacgac gcctgcttcc ttaggtgctc tgcaaagaga
atacggcaga gtgcaccccg 140640aacacgcaac ggtacagtca caaagatgac actggctcca
agtgtcttca gcaaaatggg 140700aacgtgtcag aagagtaggg gggtctctca tggcgtgaat
acaaggcccc tagaaaggaa 140760gagacagctc agcccaccac cctcagagga aggtcttggt
tctgctttac cactgagtag 140820tttcccacct ccgacaggag aaggcctcag tacctagacc
tcaggaccta gaaggtctca 140880gtacctaggc gacctcagta ccgacgaggt ctctgtacat
aggagatctc cgtgcctagg 140940agacctcagt atctaggagg tctcagcacc gtggcgacct
cagcaccgag gcaacctcag 141000taccgaggcg acctcaatac ctaggaggtc tcagcaccga
ggcgacctca gcaccgagga 141060gacttcagta ccgaggagat ctcagtaccc aggggacctc
agtacctagt aggtcaaact 141120gagagacgaa acgtagaggg gaggttgtca cgggctgggg
gaggcggaaa ggagagctgt 141180tcagcttgga aaggtgcaaa cgttctgcag acagacggtg
gcgccgagcg caccacgcga 141240tgtgctcagt cccaccgacc tgcgccctga aaacggccag
tatggcaaac tccgtgtttt 141300gtatattgtg ccacaaagaa gaaaaagtgt cttagggaga
gagggaggga gagagggagg 141360gcgaggagcg agggcgccgc ggccggcccc gccccgcccc
gccgcgcagc cccctacagg 141420ccgagcagct cgcgcggggt cccgcgtccc ccaggtcggc
tcccgcccgg ggctgggccg 141480ctgcgggaac agggttggcc caaggcagcc gccggtcccg
agcagcatgc gcgatgcggg 141540ctgggcagga ccccgtggcc cctccgccgc cctctcagtc
cgcgcgaggg ccccactcgg 141600ggctcggccg ggctccggga acgcggtctg cggtccaggg
gccgcgagcc tccgccgctc 141660ctcggcctcg tgggcccggg cgctgggtgg ggccgcgggt
gggcgtcagg ggccaggctg 141720ggcgccgagg tctgcaaagg ggcggagaag acgggcttgg
gctccgcgca gaacctgcga 141780gtgggcggcg gtgcacctcc cacccgggtc acctcggtgc
cacccatgcc tgcctcagtg 141840caggcggacc cacggccctc cacgccctcc ctcgctcgcg
tgctgcccgg ctggccgctg 141900ttcgcatcct ctcgctaact ccgtggggtc ccgcccattc
gggcgactgc cccggctgca 141960gcccacccgc taatctcggc tatcttccct cactcagttc
ttcgcctcca ccagcttcgg 142020ctcttttcgt cacccctctt tactccccgt tcctctccgt
cactttccgt catctccgaa 142080taggctcggc cggctgcatc tcaccatttc gctttcctct
ttgtcgccct ctgataaatt 142140tcgtgactct tcgtcactgt ccgtcagtcc ccgtcacttt
ccgtcaattc tcgccacttt 142200ccgtcgctct ccgccgccct tcagctccgc tcggctcttc
tccgtcagac atcgtctact 142260ttcgtcactc tccgtcaccc ttcgtcactc tccgtctgct
ccctaccccg cactccgggt 142320ggagaaagcc tcagggactt ttcctgccct tagccctttt
ccgtccctct ccgatcctgc 142380tgtctgtcag tccctggtta tttctggtct gctcgtgact
ctgtcctcct cccttcactc 142440ctgggagggt ggcctggtcc ctcctgagag gcctctcccc
actacccggc ctgaatgatg 142500gtggtgagcg ggaggtctcg aggtgatccc gagggaagga
gcgggggtct gagggtggtc 142560ccgagaggga cccgaggggt ggagcggggg gagggtctgg
agatggcccc gaggaggtcc 142620cgataggagg agcggcagtc tgggggtggt gccgagggaa
gaagccgtct ggtgtggtct 142680ggaaaatggg agcagggggt ctggggtggt cccgagggga
ggagcggggg tctggggtgg 142740tcccgagggg aggagcgggg gtctgaggtg gtcccgaggg
gaggagcggg gggtctgggg 142800gtggtcccgt gggtaggagg gggggtctgg ggatggtcct
aagaggagga gcagggggtc 142860tgggggtggt cccgagggga ggagcggggg tctggggtgg
tcccgagggg aggagcgggg 142920gtctggggtg gtcccgaggg gaggagcggg ggttctgggg
gtggtcccga ggggaggagc 142980gggggtctgg ggtggtcccg aggggaggag cgggggtctg
gggtggtccc gaggggagga 143040gcgggggtct ggggtggtcc cgaggggagg agctgggggt
tctgggtgtg gtcccgtggg 143100taggaggggg ggtctgggga tggtcctaag aggaggagca
gggggtctgg gggtggtccc 143160gaggggagga gcgggggtct ggggtggtcc cgaggggagg
agcgggggtc tggggtggtc 143220ccgaggggag gagcgggggt ctggggtggt cccgagggga
ggagctgggg gttctgggtg 143280tggtcccgtg ggtaggaggg ggggtctggg gatggtccta
agaggaggag cagggggtcg 143340ggggtggtcc cgaggggagg agcgggggtc tggggtggtc
ccgaggggag gagcgggggt 143400ctggggtggt cccgagggga ggagcggggg tctggggtgg
tcctaagagg aggagcaggg 143460ggtctggggg tggtcccgag gggaggagct gggggttctg
ggtgtggtcc cgtgggtagg 143520agggggggtc tggggatggt cctaagagga ggagcagggg
gtctgggggt ggtcccgagg 143580ggaggagcgg gggtctgggg tggtcccgag gggaggagcg
ggggtctggg gtggtcccga 143640ggggaggagc gggggtctgg ggtggtcccg aggggaggag
ctgggggttc tgggtgtggt 143700cccgtgggta ggaggggggg tctggggatg gtcctaagag
gaggagcagg gggtctgggg 143760tggtcccgag gggaggagcg ggggtctggg gtggtcccga
ggggaggagc gggggtctgg 143820gggtggtccc gaggggagga gcgggggtct ggggtggtcc
cgaggggagg agctgggggt 143880tctgggtgtg gtcccgtggg taggaggggg ggtctgggga
tggccctaag aggaggagcg 143940ggggtctgca tgtggttttc aggggtggag catggggtct
ccctgtggtt cggagggtgg 144000agcagggggt ctggggttgg tacttttggg cgggacagcg
ctatttctct ttttggtccg 144060gttcccatct gctgatctgg gggtccttgt gatcctgaca
ggtggggccg aatgggaggg 144120tcaaggtgag gggaaggaag gagtggcagc ctggtcccaa
gggagcagga aagggtttgt 144180ggttcagttc tgatgtgtga cccatccata ggagaatgga
cacctcagac tctctcaatc 144240ctggccagtg gcaggtccca gtagctgcct tccctggctg
tccttgaggc tcactggagg 144300atacttcttt ttcattctgg caaattttaa aaaattcttc
tatagatctc agtgagttca 144360aagctgcctg tgtgcaggca tagatccgtt ctttgctgag
cttccactct agtcggctga 144420aaggaaaggg taatatagct ggaaaaggta tcctggggtg
attagaggat tctacatttc 144480atcttagaaa gggatattga caggagacca gaacttccag
atcctcttga atttcaagaa 144540ctacttccaa gcctggacaa tatcgggagg cctcatctct
acaaaataaa aattaagaaa 144600ttcgccacgt gcgatggcac actcctgtag tcccacctac
tctggaggct gaggcgggaa 144660gatcgcttga gcttgggagt ccgaggctgc agtcagctgt
gatcatgcca ctgcactcca 144720gcctgggtga cagagcaaga ccctgaaaaa aaaaagggag
ggagggaagg agggagggag 144780ggaggaagga aggaatgaag gaaggaagga aatggcttaa
gctcagagag ctgtgtgtgg 144840cccccagctc ccacccccac caaagggcct gcaaacccac
ggaggggcag gttgtcttga 144900gctggagcta cggggacggg gggacctgaa ctgtcggggt
tagggttagg gttaggcttt 144960gagatttcgg gttacagaat atagatgggt ttggtcctgg
gaaaattcca ggtctgggtt 145020ttgcggttgg gggttggtct caggtgagat gcggcaggtt
tacagtgttt gcaaggtatg 145080tacagattta tatggtgcta ttgcttgaat gtgttctcca
gatttcatgt gttggcaatt 145140ttttttcttt tctttttgac atggtgtctt gctctgtcat
ctatcaccca ggctggagtg 145200caatcgtggg atctcggctc gctgcaacct ctgcctccca
ggttcgagcg attctcacac 145260ctcagcctcc tggtagctgg cattgtggca ggacaagccg
cagacaaaat tcctcagaca 145320ctgggttaaa gaaggaaggg ctttactctg ccaggagcat
cggcacactt gcgcctgaag 145380agccaagctc cccgaaaacg aaattcctgg cccttttaag
ggtttacaac tctaaggggt 145440ttacgtgaaa gggttgtgat agatcgagga agcatgggga
acgtgactgg gggctacacg 145500catcagataa cagaacagaa agttttgcag ggcttcctca
tacagtgtct ggaatttaca 145560gataacacaa gtagtttagg tcaggggtta atattattat
tattattatt ttaaccacca 145620gggtcgggtg gtgctgccaa gatcatctag ctatttatct
tacttctgtt tttttttttt 145680tttttttaag ctttttgctt tctccctttt tccctgtttt
ataaactaag gaagcggtgt 145740ggggaaggga agggcagcag gaggagtggt ggtctccttc
cttaggatta caagcaccgg 145800gcctcattcc tggctaacgt tttttgtttt ttttttgtat
ttgtattaga gatggggttt 145860caccatgttg gccaggctgg tcttgaactc ctgacctcag
gtgatcgcct gccttggcct 145920ctgaaagtgc tgggattaaa agcacaaggc agctgggtgc
ggtggctcag gcctgcaatc 145980ctagcacttt gggagaccga gatgggtgga tcacgaggtc
aggagatcga gaccatcctg 146040gctaacatgg tgaaaccccg tctctacaaa gaaatacaaa
aaaaaaaaaa aaaaaattac 146100ctgggcgtgg tggcgggcgc ctgtagtccc agctactcag
gaggctgagg caggagaatg 146160gcgtgaaccc gggaggcaga gcttgcagtg agccgagata
gcgccactgc actccagcct 146220gggcgacaga gcgagactcc gtctcaaaaa aaaaaaaaaa
aaaagcacaa gccatcgcgc 146280ccagccatgt gttggcaatt taatccccga attcatgtcc
tgattggaga tatggccttt 146340gggaggcaat taggattaga taatgttatt aggttgggtc
cccagtcatg ggactcgtgg 146400ctttataaga tgaggaagag agactggagc ggacacgcag
tcttgccctc tcctccctcg 146460cccgcacact cttgctctcc cctcccctgc catgtgcagc
cctccactgg gctgtgatgc 146520tctaggcctc cccagccacc agaacttgcc ctcccctccc
cggccatgag tggacacgga 146580ctcccgccct cccgccatgt gccgccctcc actgggctgg
gatgctctgg gccatgtgct 146640gcctggggtc caggggccgt tagtctccgc cgctcctcgg
cctcgtgggc ccgggcgctg 146700ggtggggccg cgggtgggcg tcaggggcca ggctgggcgc
cgaggtctgc aaaggggcgg 146760agaagacggg cttgggctcc gcggagagac tgccaggggg
cggcggtgca cctcccaccc 146820gggtcacctc ggtgccacgc atgcctgcct cagtgcaggc
ggacccacgg ccctccacgc 146880cctccctcgc tcgcgtgctg cccggctggc cgctgttcgc
atcctctcgc taactccgtg 146940gggtcccgcc cattcgggcg actgccccgg ctgcagccca
cccgctaatc tcggctatct 147000tccctcactc agttcttcgc ctccaccagc ttcggctctt
ttcgtcaccc ctctttactc 147060ctcgttcctc tccgtcactt tccgtcatct ccgattaggc
tcggccggct gcatctcacc 147120atttcgcttt cctctttgtc gccctctgat aaatttcgtg
actcttcgtc actgtccgtc 147180agtccccgtc actttccgtc aattctcgcc actttccgtc
actctccgcc gcccttcagc 147240tccgctcggc tcttctccgt cagacatcgt ctactttcgt
cactctccgt caccctccgt 147300cactctccgt ctgctcccta ccccgcactc cgggtggaga
aagcctcagg gggtcccgac 147360aggaggagcg gcagtctggg ggtggcgctg agggaaggag
cagtcgcgtg gtccggagga 147420caggagcagg gagtctgggg gtggtttcgt ggggaggagc
agggggtctg ggggtggttc 147480ccaggggagg agcgggggtc tgggggtggt cctgagggga
gaagaggggg gttactgggc 147540gtggtttcgt ggggaggagc agggggtctg ggcgtggtcc
cgagggcagg agcgggggtc 147600tgggggtggt cccgagggga agcgtggggg tctggggatg
gcgccgaggg aaggagctgt 147660ctggtgtggt ccggaggaca ggaacagtgg atctgggggt
ggtcctgagg ggaggagcgg 147720gggtctgggg gtggtcccga ggggaagcgt gggggtctgt
gggtggtcct taggggagga 147780gcgggggtct gggggtggtc ctgtggggag gagcaggggg
ttctgggggc ggtcctgatg 147840ggaggagcgg gggtctgggg atgatcctga ggggaggagc
tggggtctgg ggatggcgcc 147900gagggaagga gctgtccggt gtggtccgga ggacaggaac
agtggatctg ggggcggtcc 147960cgtggggagg agcagggggt ctgggggtgg ttttcaggga
tggagcatgg ggcctccctg 148020tggtccagag ggtggagcag ggagtctggg ggtggtactt
atgggcggga cagcactatt 148080tctctttttg gtccggttcc catctgctga tctgggggtc
cttgtgatcc tgacaggtgg 148140ggcagaatgg gagggtcaag gtgaggggaa gggatattga
caggaggtca gaacttcaag 148200atcctcttga atttcaagaa ctacttccaa gcctggacaa
tatcgagagg cctcatctct 148260acaaaataaa aattaagaaa ttcgctgggt gcgatggcac
actcctgtag tcccacctac 148320tctggaggct gaggagggaa gataacttga gcctgggagt
ccgaggctgc agtcagctgt 148380gatcatgcca ctgcactcca gcctgggtga cagagcaaga
ccctgaaaaa aaaaagggag 148440ggagggaagg agggagggag ggaggaagga agggaaggga
gggaggaagg aaggaatgaa 148500ggaagaaaat ggcttaagct cagagagctg tatgtggccc
ccagctccca cccccaccag 148560agggcctgca aacccacgga ggggcaggtt gtcttgagct
ggaaccacag gggcgggggg 148620acctcaactg taggggttag ggttagggtt aggctttgag
gtttcgggtt acagaatata 148680gatgggtttg gtcctgggaa aattccaggt tgagttttgt
agttgggggt tggtctcagg 148740tgagatacgg caggtttact tgggcctgaa gagccgagct
ccccgaaaac gaaattcctg 148800gcccttttaa gggtttacga ctctaagggg ttcacttgaa
agggtcgtga tagatcgagc 148860aagcatcgga acgtgactgg gggctacacg catcagataa
cagaacagaa agttttgcag 148920ggcttcctca tacagtgtct ggaatttaca gataacacaa
gtagtttagg tcaggggtta 148980atattattat tattattatt ttaaccacca gtgccgggtg
gtgctgccaa ggtcgtctag 149040ctatttatct tacttctgtt ttttttatct ttttgctttc
tccctttttc cctgtttcat 149100aaactagaga agggggtgtg gggaagggaa gggcagcaga
agtggcggtc tcctccctta 149160ggattacagg caccctgcgt taacctcaaa attgtctcag
tcccaaagaa ggggctagat 149220tttcttttat acttttgttt agaaagggga gtggcggtct
agttaaaaga attttacata 149280agtaaatcag gcaaaatgtt aaaaggataa atggttacag
gaaagtaaac agttccaggt 149340gcaggtgctt taagactatt acaaggtgat agacgcgggt
aattgggcgt tatcaatcgg 149400acgaattcct ggggactgcg gatgtagctc gccacagtag
gttgtcagtt aattgcattc 149460tcggatgtcc tgggagtcag cttgcacgag ttaagtcttt
gaggaagggg ctgccagtga 149520aagagccaag atggagtctg tccggttctc tcagttaagg
gagagtcctt tcaggtggaa 149580agaaggctag gtgattgaag gaaagggaga gtctaaaaac
agggttagca aaaatgaggt 149640tgggcattac agttgtaccc tccatcgcct cttccaatct
caagcaattc cataacttgg 149700aaaacctcag gcaaggactt cctggaatat gtccactgta
acgaccaggt tttccagtgt 149760gttatctaca ccctgtaacg ctgttaggta cataatgttt
cagcaatctt tgttcttcac 149820cagcactctg agtacatgaa aaaggccaag atgcttcttc
agggatgaat tttgctactt 149880tttaaaggag acttaagagg cacttttggc actctaagtc
tttcttcaaa tgatgaaatt 149940tgttacctat ttaactcatt gctgtgacgc gttttccaat
tctatgttcc cttggttttt 150000gttgtatttt tttctgcatg aactctacat catttactca
ctctgaacga cagaataaaa 150060gaaattggcc accatatcat actcggaagg acaatcatgg
ccatgagaca caaaggactc 150120ccagccctgg gcccaggccc ccctcacgca tgcagccatc
gcggcactgt gcctgagtgg 150180gccatatgca tggtggggac ccgatgctgg gagacacagc
tcagggcaca ggggccccaa 150240gaagccatag ctggggaaag ctcattcccg acagggctca
gctccaacct gaaactagag 150300tcccaccctg gggtttccat ggtggtggta aaccaaccac
agattttggg gatatgactg 150360ctccctttgc cacgatagct tcttccacgt gcccctggcc
tgatgaccag accactagag 150420aggggaggcc cgagtcccag ggatgggtgg gttgcaggca
gagctggggc tggatggacg 150480gtgagtggtg agagctcaag gtgcagaagg ggctcctgtc
ggggactggg ttaacaggga 150540ccgggacaaa tagacgggga ctcccgagat gagaaagacc
ttttcgtaca aagtgtttgc 150600atcagtacct cacaatgaaa agaataagat aaataacagt
acaaaaaagc aatcaccaga 150660tcagctcaag gcactctttg aagtcccccc tgtgtaggga
agttggaaga catatctgtg 150720tggcccatag agagtagatc ccaaagacag aaggcccaag
tccctaaatc cccacagggg 150780aactgtgtta cagaccagga gctcatgtac agggctgtcc
cagggcccct aaattccaga 150840agggaactgg gttagagtcc aggggctcat gcaacgggct
gtccctggtc ccctaaatcc 150900ccacagggga actgggttag agatgaggag ctcattttcc
gggctgtcca ggtcccctaa 150960atcccagatg ggaactgggt tatcaaccag gtgctcttct
aggggttgtc tcagggtcct 151020agtgtgtctg gaattggtgg gttcttggtc tcactgactt
caagaatgaa gacgcggaac 151080ctcgcggtga gtgttacagt tcttaaaggt ggcgcgtccg
gagtttgttt cttctgatgt 151140tcagatgtgt tctgagtttc ttctttctgg tggggttgtg
gtctcactgg ctcaggagtg 151200aagctgcaga cctttgcggt gagtgtcaca gctcataaag
gcagtgtgga cccaaagagt 151260gagcaatagc aagatttatt gcaaagagtg aaagaacgaa
gcttccacag tatggaaagg 151320gaccccattg ggttgccact gctggctcag gcagtctgct
tttattctct aatctgctcc 151380cacccacatc ctgctgatag gtccactttc agagggttag
ggttagggtt agggttaggg 151440ttagggttag
1514502146152DNAMus musculus 2gatcaataaa acactgctca
gcgtgctacc tctatggaga gttcacttcg taccatatac 60gttctctttg cgcgttccgc
ttttctgcca cacttttctc tattccgtac aaacaatcct 120aattaatatc tacaatttta
acctctgata atacatttta cgtaagagtg gttgagtttg 180gatatctatg ttatgaggtg
atcaatggat tcacagtgtg tatgtggtta ccggcttctt 240ttttaaaact acatccgggc
tggtgagatg gctcagtggg taagagcacc cgactgctct 300tccgaaggtc cagagttcaa
atcccagcaa ccacatggtg gctcacaacc atccgtaaca 360agatctgact ccctcttctg
gagtgtctga agacagctac agtgtactta catataataa 420ataaataaat ctttaaaaaa
aaaaactaca tccatgtggt tttccggagg ttgttaattt 480catgggtatt tagtcagctg
ttctcatgac tgcgatacaa gtgagcatta tccattcctt 540gaacaggaaa gagaagccga
taaatattgt catcatgttc agtcctcatc atctcctttc 600tgtgttgaga tcccttcacc
cagctcatct gaaaacagtc gtcgaacgcg gaagggaatc 660agccgagaga tactcactga
caacattggc ttgtccggtg aatatggtgt actggagctc 720gtaggagacc acgctgaact
cgtcctctga ggtccagtgg acggtgatgg tgtcatagga 780agcggtgcag agctcttctc
taatcgtggg agcgttggga gctgtggaca tcacacgcat 840gtcagcggag cagcagatac
cattaggacg acaatttgga ggtattcgac tgttgaagca 900ggtcttcctc ctaaacaggt
ctagcacatt tactaacagg aggttttggt tccagagcgc 960tcagccgtct acttaaagaa
tgtttcaggg tttatctgtt gttgattttt ctaagcggtg 1020tgactaaagc cagccagccg
gccgctaaga cgtcacctcg atttatcatg agaatatatt 1080tatgagagta agagaacaat
agcttcttgt gtatgaagaa agatagatca gagaaaaagt 1140aaccatggca gactttcata
atgtcattct catttggtag ggggtggggg gtggaaatct 1200tactaatcaa ggactatagg
atcgacattt taggtattgt aggacagact tctgctctcg 1260cacctactta accctgccat
tagagcggat gtagatgatt tgtacgtaaa gagtacgacc 1320agactctcat aaaatcttat
ttacaaaaca gccacagggc ctgatttggc ttgaaaccca 1380ctatgccaat ctctcgtcca
cacgccacca gctattttaa aaaatatcac ggtgatctgc 1440taagaaatca acaagtcatt
taaattcttc ctttatcttt attttcttgt ccctgtttct 1500acttggtctg tgttatttag
gttagaatac agcgcggaca ttcatcttta taggactatc 1560agatagcatt tcagagactg
aagcacgtgt atgggtttta gaagataatc gactcaatgg 1620taaagtgaat agacactgta
ctagagagaa catagaagag agtaagacga tacctgttag 1680gtaatccaga cactctagca
gtttcttctc ccgggaaaaa tccaaggcaa aagtgtcaaa 1740cgtgtcattg aggttgattt
cgggaattag gacctgggag gatgcagttg ccatggagac 1800tctgtcattt aaacaagaca
ctgttttaag aaatgtcaag gtggctttta tcaccactgt 1860gaaggagtga gaacaaaacc
aaaggaaaag aaatatcagg gttttaaaaa gcaccccctc 1920tgaaaaggcg tcacgtgcga
acgcaaacaa cctcacagag aaagcagagg aattgggaga 1980ggtaacccgg tgccaccccc
cccccttctt taaaatatcc gaaaaagtcc ccacggaagc 2040agaagaatct tcatatttcg
tgctgctgtg tatttgacag cccggcccgg tcacatcgaa 2100ccccggccag aagcgcacag
cttcaggcat ctcttcacac atctgtctgg gaaactgtct 2160gttcctttca gactcgcccc
tgccccactt ccaaggggag tctccagaat ttcaaactgc 2220atcaaaggca gagtgaagat
taaaaaagaa tgtctccaga tcttggatta gtttaatcaa 2280ttactagccc ctctctaaaa
taaacatgaa aaggggggga ggggttgtct ggctctttct 2340cgttctcccg ctattcgcct
tttttcccct accgtcttcc caacagatgc cacgggaaat 2400attcctgagc tttctcagaa
attccccagt cggcacacaa tctcgtccct acgctcagat 2460tttctggtga gtgctccctt
gtataaagcg taaagcaagg tatgtgtgtc tgtctcctgt 2520gtgctcttga gttcatttgg
aaagtgactg acagcagaac aatctagcgg gtgctaaaat 2580gcaagtaatt atgtttacac
aaagaaaacc atgtcttgaa taatgctact actgagcata 2640gagaatgatc tagacttatt
ttgatgtgtt ttatggtttt gttgagttca agctgaaggc 2700tgtcacggaa agggttttat
catgtcgaag gaaagcgttc ttagctggag caaaccagcc 2760gaagcttcca ttctctctgg
cactcgacct ctaacagaaa acaagtcagt cggagagcaa 2820ggccgaccgg tcagtcccac
gcagatatga gccaccatca gcctgacagc ttcccagctg 2880tccctgcacc cacctctcag
tgatattctt tgctgtctgt agaaaacggg cgtggtcatt 2940ttccttcagc gagtgctccg
cttgcgagat gagcgatgca gacctctcaa ggcactgttt 3000acagtttgca atctgctgag
ctaacttgcg gagcctgatc acctggaacg agagaagcac 3060ggcgggcgag gtcacacgtt
aaggatcgat cgcttgggag gtggctcagg gctgaaccct 3120tcagaggcgt gaggtctgtt
ctgtctaagc agagagaggt tgaaatccgg aaggcaaatt 3180tttggaactt gaactttcag
tctttggaga agccttagtc acctgtttga tgaggagaca 3240ctaattcgtg tcagtgtgac
actaactcac actagcatcg ctcattactt ctctgttgaa 3300ggggggaaag gtgtccgctg
gcaagtgaca aacggtcacc gaatctcttc cttctgccat 3360cctacctaat gacttcagga
ccttagagaa ccctggaact ctctccatct caggttttca 3420atatgccttt aagaaaataa
aacatgtctg taggtgtgaa ttcgaggctt aagttaaaaa 3480cagtgaaaaa aaaccctaca
aagttctttg taatccacgt aataaagttg tgacatgaaa 3540gcattaggta ttcctatttt
ccatactgcc taaaacctgt gtatgaaatt aacagagagg 3600gagcattttc ccattgattg
atatttttct tattggactg atgagagaaa gccaaaaaaa 3660gcacagctgg gccatttcct
ctcactgtaa acgtcatttc cagtcacttt gtgcagcatg 3720gtaaaaacac atcgttcatt
gtaaaggtag gtcttgtccc tatcaggaga agtgtgtacc 3780cgagtcgaac aaaataacac
catttcacac cagatagaac agagcctctg gcaacattat 3840ctagagagtc gaggcagccc
tctagcctaa ctcagggtgt tagaacacat ctattaggaa 3900ctgtcagagg aagggagaat
tccagaagga taagttaata gtctcaacca taaaccagat 3960gagtggaata tttaattata
taacataaag aagatttaaa tggtacggcc aagttgaagg 4020cagatgataa aattctcacc
aaacgagatg aggtcagact actcttctgg cttcatttca 4080tgtcactctc ttagcctttg
aataggcaca gcagagacca cacgtctcaa aaatgacggc 4140tcttcaatgt catatttttc
aggtttttcc tctgaggcta tgtggagatt aacggtgatg 4200tttaaggaca agaagaataa
ccgaaacagg agatattgat gtaaaagaaa ttgagagcat 4260actgtgaaac tgccacgatc
ttctcgagtg gacttccatg tagagcgtac ttttcattac 4320aggtcagttg acagttgcct
cggagattca caaacactgt gtgcgataga atcagctggg 4380gatctttccc aggaaaactc
tagatgtctg ggcacatcct ctggcattct agttaaggag 4440ctgccattgg cagagccaca
gtaatttgca tttgaacgag caacgcatgt ttttaagtct 4500ccgggtgatg aatgactagt
atggtcggga ccagcatttc aaatatcaat ctcgctttaa 4560tctttgagtc catggacatc
tgtcatgctt gaatgtcact cagacccttt tgtcccttct 4620tacctcgatg gaactcccca
ggcagaggcc aaaactcagt ccccacggaa gcagaagaat 4680attcatattt cgtgttgctg
tgtatttaac agcctggccc ggtcacatcg aaccccagca 4740agaagcgcat caatgataat
aaaagataat aaaaaagaaa aacgaacgtg cacgcagatg 4800ctttccaaaa gaatcaacgc
tcacggaaac caaaaacaag tgtcctttga aaaaaaggaa 4860aatcgaacgg tcacgaccac
cgcattctcc tctgtcacca ccgggtggcg acagagagca 4920cgccgggaaa aaaaaacttc
ctccgagggg tcggattgcc caatttcttc tgtagctgtt 4980ttctgtcaca taattgtcta
cgagtttacc tccaaaactt attgattgca ttcccgtctg 5040tgtgtttctt ctttgagtcc
ttttttgtct gtgatttctt tatctctaaa ctgtttcttt 5100tcaggtctgc gtcctcttct
gcaaaacgaa tcttaccgga aattagataa tgctgctgat 5160tttgctggct gtgcttttag
aaactcaaga tttcttggct tgcttcggaa atgagctcag 5220cacctcagtt ttaaagaaaa
gaatctgaaa atagcttctt gttctccttg gtgtgctcta 5280atggttttac ttttctgctt
tcccctaacc aggctcctgg gctcagcgct ctgcaatcca 5340atctcactgt ggactcctgt
ctcatctctg tgtctctgag gcacctgtct ggtgtgataa 5400tagaatgagt ggagtacggg
tcctcttaac gactgacttg ttccagaacc tcagaactga 5460agtctgccaa aagctatgat
gccaggcaga catcggcaat actctcttcc cgtccctcgt 5520aatgaataag aagccttctg
cagtctgtgg cgctgaggca caggcctggt ttctgccttc 5580catccgatcc aaagcaattc
cagattcttc caggatgttt tttaggcaca ggcatcggaa 5640ctgcaggcat gcccgtatct
cttcaaccat gcctgtgctt ccagccacag ttgtggcatt 5700gcactttcat gccattcctg
cttcaccgaa atgctgctct catttcactc ttcaccgttg 5760gagtccatgt ctattaatgg
tgtatgtctg cagcggagtg agtgctacaa aagatggact 5820ctacctataa tcatggccca
aactggaata ccttttatta ctatcctcta gctcctgaaa 5880ggaaacccca ggccgtgaaa
ttcaagctgc agctgagtaa gggtaagtaa gtacggttgc 5940tgcagaggta tgaaaaagtg
ccactgcaat ctgaagatgg actcttagcg aagtccacat 6000cggcaccttg ggaatctttc
agtatgctac cttccatacc aaaggaactt tgtagatgtc 6060taggttaaga atcttaaggg
gttggggtgg tccaggatcg tctgggtaat ctctacataa 6120ttcctaaggt ctttatgaca
gagagacagg acggttcatg tcagtgaagt agatagcagg 6180atgaagacag aaggcagagt
gctaatgact tagttgtgag ccaaggacca tggatgacct 6240ccagaaactt gacaagacaa
gcatagctta ctaacattgc ctttaaccta tgtagccttt 6300agtacagtga gactgctctc
agacatcaga acagtaagat aatcaataag aaggttctaa 6360gctacacagt tttggtaatg
tgtaatagta cgatagaaac catcataaga agaatacaga 6420accaattaaa caggagaaca
gaggcttttt aaaaaaattt tttgagctac attgcataga 6480ttaacaaata taccaaatgt
aaatttctta cacttccaga ttactagacc gttaaattcg 6540agaatttatc accacaaaaa
taagtgtttg aggtgatgaa tatgttactt agcttgattt 6600aattattata cattctattc
atgaaccaca gaatcatgtc gtatccacca acatgtacac 6660gtgtaacttg tcaatttaac
attaaaacga taaattttct aaagaaattt atgtgggcat 6720gtagagtatt gatcctggca
tgcaaccact tgacaatagc agattatctt cttggaacat 6780aatagcaact aaccatggca
gaaaaacagg catctgagaa actaggagac gaaaggaatg 6840agagatgagt ccacatgatg
aaagaagatg cactatgcgg aagtatattc tcagtagatt 6900ctaggtggac acttactgcc
agaggcattg agcaaacatg gtgccatgct attgggaatt 6960ttaagaaata tgaataattc
tctttcggtt cttcactact ctttgtcgag tattttacta 7020cagcaacaca aaatggacca
aggcaggtag ttaagaaggg attatgacga atgcagagag 7080tacgatttgt ttttaacttt
caaagctgta gatgttggag agaaagtata tattcttcag 7140gtgagaaata cagaaccttt
ttatcaagga aaccatacct tgccttcttt aatctttgtt 7200ccaataattt gtcttcgttg
ctgaatgatt tcaatgagaa gatcacattc ttctgtcagt 7260ttggcttctt gacgggatgc
attgacctac aggatgaata aaatggcatt catcggaatt 7320tgatcttagc cattctgagt
ggctgtgagg tggaatctca gggttgtttt gatttgcatt 7380tccctgatga ttaaggatgc
tgaacctttt ttttttcagg tgcttctcag ccattcggta 7440ttcctcaggt gatagcccaa
aaaacttaga atacccaaga tacaagatac aatttgcaaa 7500acacatgaaa ctcaagaaga
acgaagacca aagtgtggac actttgcccc ttctcagaac 7560tgggaacaaa acacccatgg
aaggagttac agagacaaag tttggagctg agacgaaagg 7620tggaccatct agagactgcc
ttatccaggg atccacccca taatcagctt ccaaacgctg 7680acaccattgc acacaccagc
aagattttat cgaaaggacc cagatatagc tgacgaaatc 7740caggcccatc catgttcctg
aaaatgtgaa gactccattc tttttatggc agaatacaat 7800tcccatatgt gtatatacca
tattcttaaa atccactctt ctgtcaaggg aactttaggt 7860tgattctata tcttagctat
tgtaaatagt atagcaataa atatggctga gcaagtatct 7920ctatgttagg atatggagtc
ctttgggtac atgaccagga tttgtataac tagttgtgtg 7980tgtgtgtgtg tgtgtgtgtg
tgtgtatttg tataactagt tgtgtgtgtg tgtgtgtgtg 8040tgtacccttc aaactgagct
tcattgtgaa tacactactt tgcattgcca ccagcagtgt 8100ataaaggttc ctttcacttc
tgtattcaca ccagcatctg ttgttgtatc taataggact 8160ttagaaacat tctttttttt
ttttttttcc tcattggacc atgtctggct gaagtgagtt 8220agccacctac aggctttcaa
agcagaactt cccgattcat cctgccaaaa ggatatactc 8280attcgagaga tggcttcctg
ttggtacaca gaaggaacac tgaagtaagc ctgggacagg 8340ataaagccaa tgtgtcagag
acaggaaatc ttacttctga gtattcaggg agaaaggagc 8400attgctcaat gcactaggaa
ttctacaaaa atggttaccc cccccctgag attacacagc 8460ctaggaacca tgctggccct
caatcagtgc aattttgaaa ctgcaccgct gcaccactaa 8520acaattacac tttcctttta
aggctgttaa cctttctgtc tggtagtttt aaacacagtt 8580atctacactg tatatttgcc
taaaagcagt ctttatggca ccatcacaag ctgggtcatt 8640ccatactcat ttaaattaag
ggaacccaga gaaaggaggc gacattcaca tatgatgtcc 8700tgtaagtgtg gttatttgga
ctccagagca cttgtctctg tatatctgta actttgattc 8760tgcatctgat tataaagtgg
atagttttat ttaaaaagca tggtccggct ctcccattta 8820actcgaaaaa gagacacact
aaaggagtta attccaaagt ggataaattg atattttggc 8880cagtaagatg agggcatgag
gggaaagctg cactcacgtc agctctgtgc cccactgtgc 8940tctgccgacc aggtgcaaag
agaaatatga ggatctgagg gtgctttggt ttttattgcc 9000aaaggcagcc gtgatgaaca
ttccagaccc tggggcagaa gttagacaga gctgccagaa 9060ggaacaatga aagggatcct
aatagtttag tttgtacata aaaccgagcc aaggagaact 9120gagtaagcac agacggtatt
actgtaatac atctgatatg tttacatcga cgttttactc 9180tgcaactctc tcatagtgtg
gcagttcttt tgcacctgtg ttctgggaat tctacaactt 9240gaactggaga aaacaatttc
actatagttt tggccataga agggtttatg aatgctgaca 9300atgatccaat tacgttgtta
acctttttgg gctttatgca tgaatgggag tttgctggta 9360tagtttaata cgacccagag
tccaactcca aataataccg cacagcaacc tgacaaggtg 9420tcaaatggag tgggaatcta
tcacttctct tgaagtagca atgaactaaa aatctcaata 9480caactttaga tactacagtt
gctcactaca ggatctagct catccagatt atacacgtcc 9540aaatgatgta aacagcacgc
atgtgtgtgt gtgtgtatgc ttatgtgtat gtttctctgt 9600gtgcatttgt ggtgtgtgtg
tgtgtgtgtg tgtgtgtgtg tgtgtgtgta tttgaatgct 9660ggcctctatc caatgctctg
gtctggatga tgcaattgcc attgtctcca aaaaaaaata 9720gaatgttttc ccatttggaa
atggcacaat taattgaagc agaaatgctc atctttactt 9780gcagtttggc attatttcaa
agtttataaa taatgatttt taggcttgat caatgattta 9840aagtcttctg cacacctatc
cattcatttt aacaaagaat tctctgcagt gttttacatc 9900attcaagata atttatcccc
atcaatcctc tagtaaaaaa actatgatta attcattcac 9960aaaatatcta gtgctccata
tgcaaatgat gggaggtcac agaaggccag aaaaggaaga 10020aactttcaaa acagaccaaa
aagggggtgg ggggaccaaa aagagagcca cagagaattg 10080gaaaatccag tgaaggtgga
ttacaggaca gaaagatggc ttgtcaggta agggagcttg 10140cttctaggcc tgaggacttg
aattcagtcc ttggaatata cacagtggag gagagggcca 10200attgccaaaa ttgttttctg
atcttcacat aagggatata gttaacatgt acattctcac 10260acacatgtat aaacacacag
acacacacag acacacacac ggttaaattt ttgaggcgat 10320tacaaacaat gaggctagca
cactgacaat ctgctggatt tgaccttggg taaggatgat 10380tagtcagatg ggcctctatc
ttccagaaac cacagttgca attatttaca agtttttact 10440tgttccccat tactatctca
atgtggattg atactcaaat caccaacaat tccccaattg 10500gtcttttatg ttatatttgc
tataaaaaca agagtaatgg ctcttggtat tttcttaagt 10560aataaaatcg gctttctgat
ttttctaaga aaattgggaa gacagtgtga taatgagagc 10620tgtattccat atttgactta
cacagagtaa attctgagac taattctgtt taaaatttaa 10680atagaatatt tttccattta
ttggtagtca gcagctcact atgttaccca ggctctccct 10740gaagaatcca tcctctgcca
gaaaatcccc agtgctgatt gtgtgtgtgt gtgtgtgtgt 10800gtgtgtgtgt gtgtgatcac
atccatatcc tgaccacaaa cctcaatcac ttctcataag 10860cttgttttat gctccagata
acagtaactt caaacttgac ctgagggagc ttttactgta 10920atactctcct ggaggaaaca
aagcagaaca gattaaaaac ctattgtttc taaaacccca 10980gacagcaact taacacaaac
agtttgttgg gaggctctct gaagttgctc tttcaatgcc 11040tctcattccc aagccccaaa
ctgccttgga ctttacactg tttcttttct agttttaaaa 11100aaccagcact tacacaatca
caaggccatt tcatttgctt gccctctttg gttaaataag 11160ttattaaaac aatcagggag
cggaccttca agagtttcca tttttaaaag aaagcggaag 11220tgaacccctg ggaggagggg
tgaacttatg aggatgtaac atttcctact aaggcctgag 11280aaagaattca ttgattgaat
ttacaacaat gaggagttac ctctgtgctg tgagttttct 11340tagctcccgc tagcctggga
atgttatttt cctcacgaat tctcagactc ggaagacatg 11400gacaacttcg ggaagaggaa
aaggaagaac tagagtctag gaacctatga tgtgaagcag 11460gaaattcttt tcaactgtac
tgactgaaaa gaatagcttg ctggtgccca acatattcca 11520gcacctcttt ggaagtccct
taatagtgtg gcattttccc atggatgggt gattattttg 11580caggaagata aaataaaaaa
ggtaaaggac aggaaagaac atggcgccaa atgaagtaaa 11640aagaaataaa agaaagagat
gactgctcct gggtatggta gaggagaaag gtttttatag 11700atacgtgggg gagcatagcc
agaggcaaga accttagaga gagagtctgg agtggacatg 11760aacacactgc catgtgtcat
gtgaggagaa aggtgaagga gggcaagaga gaggtgagag 11820agaagaacca cgttcaggag
tcaggaggct caaagttaca aagagaaagg ataaccaaag 11880tggttggatt atttagggag
gagcggcctg tgccagagag ttcagagtaa gggttgagga 11940atgccaccca ggtgggtcct
ataacaggga gggactggtg gatacaggga acttgggggc 12000caggtctgtt gtgatatgtt
agataggtat ctcagccatt tgtcccaggt ttcaaacata 12060gcacagatta tttttcaaat
agctacaaat atcaatttct gaaatgagtt aggttttaag 12120tgcgaagcca acaaaatcta
tgtgcttctt gaaatgttgt tgtaccttca agaaccaatt 12180tccaactcag gtaccaaatg
aaacgcttct caaccctcat ctctccagag ctgctcctta 12240gctatctttc cttcatgcat
gcctttcatt tttccagaag acacacacac acacacacac 12300acacacacac tctctctctc
tctctctctc tctctctctt tctttctttc ttcttttttt 12360tttggttgtt tttttcggaa
cagggtttct ctgtatagcc ctggatgtcc tttgtagatc 12420aggctggcct cgaactcaga
aatccacctg cctctgcctc ccaagtgctg ggattaaagg 12480cgtgcgcccc caccgcccgg
catccttttt ctttaatgct tcctgctccc ttttttatat 12540accagggcat gatatcctct
ttggttcaaa tagcttttat gactctgatg gctccttcct 12600cagtcaatta tcacaaaata
acttggaatt cctttttaaa aagtattctt tgagaatatt 12660aacaattagg ataaatgtaa
tagtagatac tgttcctgcc atttttctac tcataaataa 12720ttacctagta cttacttaga
atacacttac ttccactcca aaggatttac aaagcagcag 12780gtaaatagat actcttaaat
tttgttaaga attacttcta atggtatgta cgactgtttt 12840taaaatggcc acaattaatt
gagtaatttt ttttttaatg agtatcttaa ctagaacaat 12900atctgatccc tggaaataaa
taatctggtg gtaagtttct tgaatttatt tcccatctga 12960aaattactat acatgatagg
atataatttt acatcacatt acaatgaata atattttgta 13020aattccagtc atactaaaat
tgcattagga acatggcatt agttctgaaa acattaccag 13080ccataatgca aaccagacac
taatgctttg agaagtaact tgctgaaatg ggatgaaata 13140atcacgcgat acataaacca
tttataggat ttaccttaaa gcacaggtga tttgttttta 13200ctgaagagaa ataattcttt
cttattattc caaacatcaa gtgccatcgc atcataaaaa 13260taaaatatgg cacatgaaca
ttctattttt catcctttta ttcatattcg ctttgctatg 13320aaataacgaa aacatcatgc
atcttcacta ttatttccca tattgtctaa tcaacaaggt 13380acaaacaaat gcagtttcag
tagatgagaa aggtcaaggt tctgcaactt gcagtcgcct 13440tcacgttgca tgctgcgcct
gagcagcata aaagacagaa gtatcattta gtgccaaaag 13500gaaagggtct gaggcatgaa
cccgagagcc aatcctttca acttccattc tctaactttt 13560ctttctccat ataccatatt
catcagcact taagtgacca acagttaaaa cggatggttt 13620aggcaaggaa aaacacctct
cttgttagtc ctaaatactg cagaaattta gagcttgaaa 13680aattggccaa cagacttact
tctcagtaac cagttttaaa tttccaatca tgaagaggga 13740gctcataagt aaaatcacaa
cctttatgaa cacaaaatat tttaaacctt acacggaatc 13800tccaatattt acataaaaga
gaagctttta agctgagtgt atttgaaagc ttagctttat 13860tgtgctgggg aatgtaccat
catcaacacc attgaatgac ataaaataag ctgatatccc 13920caaatccttt tttattagat
attttcttca tttacatttc aaatgctatc ccgaaagtcc 13980cctctacctt cccccacccc
ccccccgccc tgctccccga ccctcccaaa tactggaatt 14040tttaaagaca gtacttctga
aatctatagg acaagttcaa gtcctggcta ctcattaaat 14100tccataagct ttcaggcaaa
tcgtaccccc tttcctctct gtgtgtcttc atttctgtgg 14160actggttgag atgtgtgcat
gtggaagcct aaggacaacc ttgttgtcat ctctcagaca 14220ccatcccacc atctaccttt
ttttctttgg tggtcagggt ttctcattgg cctggaactt 14280atcaagtatg ctagcctaaa
cggtcagtga gggcctacct gctctccttg gcgcagagat 14340tacaagcatg aaccaccctg
acttgtgatt tgttttagaa acttaggttc tagggatcaa 14400acttgggtcc tcatgcttgt
aagtcaaacc ctttaatgcc tggacaattt cattggtccc 14460cacttctttc ttcctttctt
actttcactt gcacttgtca ctctggtaag tggcattctt 14520tcctgtttgt accctgactc
ctcgatggta atgtgatgga gaaatactga gttgacttct 14580actcaggcta ttgtgttact
taagtgtggt tgctctctgc tcctatgtga agctctttag 14640aattagaacc agcccatgct
cttccagtga gtgaaagact agatcacatt gcttaaaatc 14700cttgaactta gatgtgcacc
tgaataaagg taagcatagt tctgtcttta tgaaagatcc 14760ataagtgata tcgatataac
gtcttgtttg gttgttgtcg ttccagaatt ggggcagaag 14820tgcagattga ttactgaata
tctttgctat ctaaggttcg atatctatag ttatgcaaat 14880acaaccaatt agaggatggg
ctgtaaaaac tgtacatgtg aactacggcc acaatcaggg 14940aaaggactcg tgctattatt
ccatctttga ttctatctat gacatatggc tgagcaagta 15000tctctatgtt aggatatgga
gtcctttggg tacatgacca ggatttgtct aactagttgt 15060gtgtgtgtgt gtgtgtgtgt
gtgtgtgtgt gtgtgtgtgt gtgtgtctat ttctttttat 15120tggggaattg agtcgattga
tattaagaga tattaagtta aagtaattgt tgcttccaat 15180tagtataaat atacaaagat
aaatcataac aaaatattaa gaatgacaag aatagaaaac 15240gtcctatttt attttactac
acacacacac acacacacac acacacacaa acacacacac 15300actttcacat gtttaatgta
tatataggtt gacatattct gggttcacac atatgcaaag 15360agtggtgagc catcaacgag
aataaaagaa aaacgaacgt gcacgtagat gctttcaaaa 15420ataatcaacg ctcacggaaa
ccaaaaacaa gtgtcctttg aaaaaaagaa aatcgaaagg 15480tcacgaccac cgcattctcc
tctgtcacca ccgggtggcg acagagagca cgccgggaaa 15540aaacttccac caaaggggtc
ggatctgcct gcttcatccc ggccagggtg aggggaagcc 15600ggccaggctg gcggatccga
cccggcgagg cggtcgcgct ttccatcggt cggtccccgg 15660gaggttgtac tttgtgagat
acaggaagtg cctccatttt ggacaggaag tcgagcccag 15720gcgctcatgg gagctgtagt
gcgtctaggg cccagcgccg atctccgggg ccacccggtg 15780gcgaaaaacg cgcaagtgca
cccccggttc tctgcctcgt ggggacggat ctgggacccg 15840aaggccagcc gcggttccag
acctgcggtg cggccgtgtc ggcggcgtcc ccgggcagac 15900gggggttcag gtccgcggcc
gccgctccag gttgtacctg tagaagtgca gggacagagc 15960ctctctctgt ctctctgtct
atgtgtctaa gtctctctct gtccctctgt ctgactctaa 16020gtctctcctc ctcctcctcc
tcctcctcct cctcccttcc acccggggct gcctggcgtc 16080ggcgtccgcc atcgagggac
ccatcccggc ttccacgagt cccgcagccc ccggctctcc 16140cttctccttc cttctccttc
cttctcctgc ttccttcttc catcccggcc tgcctggtct 16200ctgccgtggc ccgcgcagct
cgggtctctg tgtctgtctg tccccctgtc ctggttctcc 16260cttcttcttc catcccggcc
tgcctggtct ctgccgtggc ccgcgcagct cgggtctctg 16320tgtctgtctg tccccctgtc
ctggttctcc cttctcctgc ttccttcttc catcccggcc 16380tgcctggtct ctgccgtggc
ccgcgcagct cgggtctctg tgtctgtctg tccccctgtc 16440ctggttctcc cttctccttc
cttcttccat cccggcctgc ctggtctctg ccatggcccg 16500cgcagctcgg gtctctgcgt
ctgtctgtcc ccctgtcctg gttctccctt ctccttcctt 16560ctccctgctt ccttctcccc
ggggaccaag cccgagtctg catccgaccg agatgcacca 16620tcccggcttc cgtgtgtctc
gccgtccccc ggtctctgtc tgtcaacctc ccttctcctt 16680ccttcttcca cccagggacc
aagcccgagt ccgtgtcccg cgcagtctgg gtctgtctgt 16740ccccctgtcc ccctgtcccg
gttcttcctt cttcctgctt ccttcttcca tcccggcctg 16800cctggtctct gccgtggccc
gcgcagctcg ggtctctgcg tctgtctgtc cccctgtccc 16860ggttcttcct tctcctgctt
ccttcttcca tcccggcctg cctggtctct gccgtggccc 16920gcgcagctcg ggtctctgcg
tctgtctgtc cccctgtcct ggttctccct tctccttcct 16980tcttccatcc cggcctgcct
ggtctctgcc atggcccgcg cagctcgggt ctctgcgtct 17040gtctgtcccc ctgtcccggt
tcttccttct cctgcttcct tcttccatcc cggcctgcct 17100ggtctctgcc gtggcccgcg
cagctcgggt ctctgcgtct gtctgtcccc ctgtcctggt 17160tctcccttct ccttccttct
tccatcccgg cctgcctggt ctctgccgtg gcctgcgcag 17220ctcgggtctc tgcgtctgtc
tgtccccctg tcctggttct cccttctcct tccttctccc 17280tgcttccttc tccccgggga
ccaagcccga gtctgcatcc gaccgagatg caccatcccg 17340gcttccgtgt gtctcgccgt
cccccggtct ctgtctgtca acctcccttc tccttccttc 17400ttccacccag ggaccaagcc
cgagtccgtg tcccgcgcag tctgggtctg tctgtccccc 17460tgtccccctg tcccggttct
tccttcttcc tgcttccttc ttccatcccg gcctgcctgg 17520tctctgccgt ggcccgcgca
gctcgggtct ctgcgtctgt ctgtccccct gtcccggttc 17580ttccttctcc tgcttccttc
ttccatcccg gcctgcctgg tctctgccgt ggcctgcgca 17640gctcgggtct ctgcgtctgt
ctgtccccct gtcctggttc tcccttctcc ttccttctcc 17700ctgcttcctt ctccccgggg
accaagcccg agtctgcatc cgaccgagat gcaccatccc 17760ggcttccgtg tgtctcgccg
tcccccggtc tctgtctgtc tccctccctt ctccttcctt 17820cttccaccca gggaccaagc
ccgagtccgt gtcccgcgca gtctgggtct gtctgtcccc 17880ctgtccccct gtcccggttc
ttccttcttc ctgcttcctt cttccatccc ggcctgcctg 17940gcctctgccg tggcccgcgc
agctcgggtc tctgtgtctg tctgtccccc tgtccccctg 18000tcctggttct cccttctcct
tcttccatcc cggcctgcct ggtctctgcc gtggcccgcg 18060cagctcgggt ctctgtgtct
gtctgtcccc ctgtccccct gtcctggttc tcccttctcc 18120ttcttccatc ccggcctgcc
tggtctctgc cgtggcccgc gcagctcggg tctctgtctg 18180tctgtccccc tgtcctggtt
ctcccttctc cttccttctt ccatcccggc ctgcctggtc 18240tctgccatgg cccgcgcagc
tcgggtctct gtctgtctgt ccccctgtcc tggttctccc 18300ttctccttct tccatcccgg
cctgcctggc ctctgccgtg gcccgcgcag ctcgggtctc 18360tgcgtctgtc tgtccccctg
tcctggttct cccttctcct tccttctccc tgcttccttc 18420tccccgggga ccaagcccga
gtctgcatcc gaccgagacg caccatcccg gcttccgtgt 18480gtctcgccgt cccccggtct
ctgtctgtca acctcccttc tccttccttc ttccacccag 18540ggaccaagcc cgagtccgtg
tcccgcgcag tctgggtctg tctgtccccc tgtccccctg 18600tcccggttct tccttcttcc
tgcttccttc ttccatcccg gcctgcctgg tctctgccgt 18660ggcccgcgca gctcgggtct
ctgcgtctgt ctgtccccct gtcccggttc ttccttctcc 18720tgcttccttc ttccatcccg
gcctgcctgg tctctgccgt ggcctgcgca gctcgggtct 18780ctgcgtctgt ctgtccccct
gtcctggttc tcccttctcc ttccttctcc ctgcttcctt 18840ctccccgggg accaagcccg
agtctgcatc cgaccgagat gcaccatccc ggcttccgtg 18900tgtctcgccg tcccccggtc
tctgtctgtc tccctccctt ctccttcctt cttccaccca 18960gggaccaagc ccgagtccgt
gtcccgcgca gtctgggtct gtctgtccca ctgtccccct 19020gtcctggttc tcccttctcc
ttccttctcc ctgcttcctt ctccctgggg accaagcccg 19080agtctgcatc cgaccgagac
gcaccatccc ggcttccgtg cgtctcgccg tccccgggtc 19140tctccgtctc cttccttctt
ccactttctt ccacccgggg accaagcccg agtccgtgtc 19200ccgagcagct cgggtctctg
tcatctctct gtccccccgt ctccctacct tctctgcctc 19260atggggtcga atctgggacc
cgaaccccag cccgggctcc cgacgagagg tgtggctctg 19320tcattggggt ccccgggcag
gcggcgtctc aggtctgcgt cctccgctcc cgttgtacct 19380gtagaagtgt aggagacgag
cctctctctg tctctgtctc tctgtctctc tgtctctgtg 19440tctctctgtc tctgtgtcta
agtctctctc ctcctcctcc cttccacccg gggctgcctg 19500gcgtcggcgt ccgccatcga
gggacccatc ccggcttccg cgagtcccgc agcccccggc 19560tctcccttct ccttccttcc
ttcagacccg gcctgcctgg tgcttggcca ccacctgtgc 19620agccccgggt ctgtctctct
gtctgtccat cctcgcttca ggccggggcc cagcccgaga 19680gagaaaggcc cggcccgtgc
atcctccctg cctccccccc ccccgctgtc tctgtctccc 19740cccctctgtc ccatctccct
ccctcctcac ccagcctgcc tggcgctgcc catggcctgt 19800gcagcctggg tctgtgtgtc
tgtcctggtc ctcactttct tccttcagac ccggcctgcc 19860tggtgcttgg ccaccacctg
tgcagctcag ggtctgtctg tctctgtccc agtgtcttcc 19920tgtctgtcct ggtcactcac
tgctttcttc cttcagacag acccggcctg cctggtgctt 19980ggccaacacc tgtgcagctc
agggtctgtc catctgtctc tgtcccagtc tctgcctgtc 20040tgtccttcct cccttcagac
agacccggcc tgcctggtgc ttggccacca cctgcgcagc 20100tcaggtctgt ccatctgtct
ctgtcccagt ctctgcctgt ctgtcccggt ctctccctcc 20160ttaaaggaaa aatcttaaag
gaaaaagagt gcagcccgct cctcccctcg cctgtgctcc 20220cgctcttccc gactcccgaa
ccgaccgcct gtcccggact cagtcagctc cggaccgagt 20280ccgtctctct gtccttctgg
cagaacgcag acacagctcg ccccagaccg cagccccggc 20340tcggtccgtc cccggtcgtc
ccggagcccg tgcacccgcg caccatccgc gtgtaagaca 20400gcccgagtca gagtcagagt
gcggatgtgc cgggtggggg atggggtggt gtgcgtgtga 20460ggtagaccag aagtccagag
agaggaaagg acgggcgggg gtgagggggg gggaagagcg 20520ggagcacggg tgaggggagg
agcgggctgg actctttttc ctttaagatt tttcctttaa 20580gatttttcct ttaagatttt
tcctttaaga tttttccttt aagatttttc cttgttaaga 20640tttttccttg ttaagatttt
tccttgttaa gatttttcct tgttaagatt tttccttgtt 20700aagatctttt taagagacct
tgctgtcttt tttttttttt ttactttttt tttccgcttt 20760cttttttgct tttttcttag
gtcaattttg ggggtgtgtc ctgacacttg aggggcgggt 20820ctaaggtgtg gctttcttgg
gtggcttttc cattctgtta agatttttcc tttttaaggt 20880ctttttaaga gaccttgctg
ccttcggtgt cttttttttt ttttactttt ccattctgac 20940tttctctgtc tctctcgttg
gggcctgtct tagatcggat ggggcgtgtt ctcacacttt 21000aggggcgggt ctaagggaag
aggggtgtgg tccgacactt tttatttaat tctttttttc 21060tccgctttct tgggtggctt
ttccattctg actttctgtc tctctcagtg gggcgtgtct 21120tagcgtgtca gaaggggcgt
ggtctaatac tttgggggcg tgtctcagag caggaggggt 21180gtggtctggc actttagggc
gtgtcctgac acttaagggg cgggtctaag ggaagagggg 21240tgtggtctgg tctgatactt
ttttttaaat tccgctttct tgggtggctt ttccattctg 21300tctctccctc tcagtggaga
cagtggagcg tgtcttagcc cagaaggggc gtggtctaat 21360actttggggg cgtgtctcag
agcaggaggg gtgtggtctg gcactttttt ttaattcttt 21420ttttcctctg ctttcccatt
ctgactttct ctgtccctcc ctctcagtcg ggcgtgtctt 21480agcccagaag gggcgtggtc
taatacttat ttttcctttt tttacctttt ttcccgcttt 21540cttgggtggc ttccattctg
accttctctc tctctctttc tctctctctc tctcgttagc 21600gcgtgtcctg acacttaagg
ggcgggtcta agggaagagg ggtgtggtct gacacttttt 21660aagatttttc ctttttaagg
tcttttaaga gacttttctt ttttttttac tttttttttt 21720tcgctttctt gggtggcttt
tccattctga ctttctctgt ccctctctct cagcccagaa 21780ggggcgtggt cttagacagg
aaggggtctc atctcgcact ttgggggcct ttgggggcgt 21840gtctcagagc aggaggggtg
tggtctgacg ctttaggggc gtgtcttaaa ccgggagggg 21900tgtggtctga cactttttta
aaaacttttc ctttttttcc gctttcctgg gtggattttc 21960cattctgact ttctctgtct
ctcccattta gggttttttt ttttggtctc actattctca 22020tcacactctc tgtctgggga
tggcaggtag ggaggaaggg gcgtggtctc acgctttaga 22080ggcgggtctt acactgggag
gggtctgaag atggccttct ttttaaactc tcatctctgc 22140cacagaaggc tgtgcttcct
tcctttactc tttggaggca ggaaggaagg aagggccctg 22200gtctcacgct ttaggggcgt
tctttacatt ttctttaacg tccctgtctt ttctgttccg 22260tctgtcgcag aaggaagaca
cacacacatc tgcatatcca tttcaactgc aattttattg 22320agggggacat ttctgtacgc
agtcaggccc cgttggcgtg ctccttcctc cgtgagaatc 22380gctccgtcct ggcggcctcg
gcgacacgcg cacctggaaa agacgggaag agagggaggg 22440gggggggtca gcgtctgtgg
acgggaccgt ggcgactcgc tgtttcagtg tgtgagtgtt 22500tggacaccac gccggatttg
agtgtgaggc ggcctcattg tgccaatcat cagttgcgtg 22560tctgctgcct ccgtgtgcag
acccgaggtt cctctgcatc tcattatgcc gctctgagtc 22620taatctgaat atctgggcct
ccgtgtgcag acctgaggtt cctctgcgtc taatctgaat 22680atctgggcct ccgtgtgcag
acccgaggtt cctctgcatc tcattatgcc gctctgagtc 22740taatctgaat atctgggcct
ccgtgtgcag acccgaggtt cctctgcatc tcattatgcc 22800gctctgagtc taatctgaat
atctgggcct ccgtgtgcag acccgaggtt cctctgcatc 22860tcattatgcc gctctgcgtc
taatctgaat atctgggcct ccgtgtgcag acccgaggtt 22920cctctgcatc tcattatgcc
gctctgcgtc taatctgaat atctgggcct ccgtgtgcag 22980acctgaggtt cctctgcatc
tcatcatgcc gctctgagtc taatctgaat atctgggcct 23040ccgtgtgcag acccgaggtt
cctctgcatc tcatcatgcc gctctgcgtc taatctgaat 23100atctgggcct ccgtgtgcag
acctgaggtt cctctgcatc tcattatgcc gctctgagtc 23160taatctgaat atctgggcct
ccgtgtgcag acccgaggtt cctctgcatc tcattatgcc 23220gctctgagtc taatctgaat
atctgggcct ccgtgtgcag acccgaggtt cctctgcatc 23280tcattatgcc gctctgcgtc
taatctgaat atctgggcct ccgtgtgcag acctgaggtt 23340cctctgcatc tcattatgcc
gctctgagtc taatctgaat atctgggcct ccgtgtgcag 23400acctgaggtt cctctgcatc
tcattatgcc gctctgagtc taatctgaat atctgggcct 23460ccgtgtgcag acctgaggtt
cctctgcatc tcatgccgct ctgcgggagt gtctcattga 23520ctgcgtgatc atgcaactct
gagcctggtt tgtcactgtc tctgtctgtc tgtctctctc 23580ctgtctctct accttaaccc
aaagctcacc ctctccctct gtctctatat ctctctgtct 23640ctctctctgt ctgtccctaa
ctctgtctct aactgtatct ctgtctgtct ccaactctga 23700ccttctctct gcctctccgt
cactgtctct cggtctctct gtgtctgtct cgttctctgt 23760gtctctgtgt ctgtctctat
atatctctgt ctcttactta ccctaatcct aaacctctgt 23820ctctccatct ctgtgtctgt
ctctgtctct ctgtctctgc gtctctgtat ctccgtgtct 23880atctgtgtct ctctgtccct
aactctgtct ccgactctgt ctctctctct gtctctatct 23940ctgtgtctgt ctcactgtct
gactctccgt gtctctacct tcaccctaaa cttaaccctc 24000tctgtctctg tctctatctc
tgtctctctg tctctgtcgc taactctatc tctgtctctg 24060tgtttctctc tctatatctc
tccatctgtc tctccatctc tgtctctatc tctctgtgtt 24120tgccagtctc catcgtctgt
gtctctgtgt ctctctgtct ctgtgtctgt ctcactttat 24180atctctctat ctttctgtct
tactgtctct gtgtctgttt ctgtctctct gtctcccttt 24240ctctctgtca gtctggctct
gtagctctgt ctgtttctct atctctccat cactgtctcc 24300ctctctatct ctctctctct
gtttctttct gtctcactgt ctctgtctct atgtctcact 24360ctgcctgtct ctgactctgt
gtctctaaat ctgtctctct gtctctgtct gtttcacttt 24420ttctatctct ctctgtcttt
ctgtctctct gtctcccttt ctctctgtca gtctggctct 24480gtagctctgt ctgtctgttt
ctctgtctct ccatcactgt ctccctctct atctgtctct 24540ctctgtttct gtctgtcttt
cggtctcatt gtctctgtct cagtgtctgt ctgtctcagt 24600gtctgtatct ctctgtctcg
cagtctctgt gtctctgttt ctgtctctat ctcgctgtct 24660ctctgtctgt ctctctgtct
ctgtctctct ctaactctgt ctaacactgt ctctgtgtct 24720ctgtttctgt tttaacccta
accctaacct caccctaacc ctaaacctct ctgtctctcc 24780atctctgtct ctgtgtctct
ctgtgtctgt ctctccgtgt ctctctacct taaccctaac 24840ctcaccctaa ccctaaacct
ctgtgtctct ccatctctgt ctctctgtct ctctgtgtct 24900ctctgtctct gtctctccgt
gtctctctac cttaacccta acctcaccct aaccctaaac 24960ctctctgtct ctccatctct
gtctctctct ctctgtgtct ctctgtctct gtctctccgt 25020gtctctctac cataacacta
acctcaccct aaccctaaac ctgtctgtct ctccatctct 25080gtctctatct ctctgtgtct
ctctgtctct gtctctccgt gtctctctac cataacccta 25140acctcaccct aaccctaaac
ctctctgtct ctccatctct ctctctgtgt ctccgtgtct 25200ctctgtgtct ctctacctta
accctaacct caccctaacc ctaaacctct gtgtgtctcc 25260atctctgtct ctctgtctct
ctgtgtctct ctgtctctgt ctctccgtgc ctctctacct 25320taaccctaac ctcaccctaa
ccctaaacct ctctgtctct ccatctctgt ctctgtgtct 25380ctctgtctct gtgtctaagt
ctctctcctc ctcctccctt ccacccgggg ctgcctggcg 25440tcggcgtccg ccatcgaggg
acccatcccg gcttccgcga gtcccgcagc ccccggctct 25500cccttctcct tccttccttc
agacccggcc tgcctggtgc ttggccacca cctgtgcagc 25560cccgggtctg tctctctgtc
tgtccatcct cgcttcaggc cggggcccag cccgagagag 25620aaaggcccgg cccgtgcatc
ctccctgcct cccccccccc cgctgtctct gtctcccccc 25680ctctgtccca tctccctccc
tcctcaccca gcctgcctgg cgctgcccat ggcctgtgca 25740gcctgggtct gtgtgtctgt
cctggtcctc actttcttcc ttcagacccg gcctgcctgg 25800tgcttggcca ccacctgtgc
agctcagggt ctgtctgtct ctgtcccagt gtcttcctgt 25860ctgtcctggt cactcactgc
tttcttcctt cagacagacc cggcctgcct ggtgcttggc 25920caacacctgt gcagctcagg
gtctgtccat ctgtctctgt cccagtctct gcctgtctgt 25980ccttcctccc ttcagacaga
cccggcctgc ctggtgcttg gccaccacct gcgcagctca 26040ggtctgtcca tctgtctctg
tcccagtctc tgcctgtctg tcccggtctc tccctcctta 26100aaggaaaaat cttaaaggaa
aaagagtgca gcccgctcct cccctcgcct gtgctcccgc 26160tcttcccgac tcccgaaccg
accgcctgtc ccggactcag tcagctccgg accgagtccg 26220tctctctgtc cttctggcag
aacgcagaca cagctcgccc cagaccgcag ccccggctcg 26280gtccgtcccc ggtcgtcccg
gagcccgtgc acccgcgcac catccgcgtg taagacagcc 26340cgagtcagag tcagagtgcg
gatgtgccgg gtgggggatg gggtggtgtg cgtgtgaggt 26400agaccagaag tccagagaga
ggaaaggacg ggcgggggtg aggggggggg aagagcggga 26460gcacgggtga ggggaggagc
gggctggact ctttttcctt taagattttt cctttaagat 26520ttttccttta agatttttcc
tttaagattt ttcctttaag atttttcctt gttaagattt 26580ttccttgtta agatttttcc
ttgttaagat ttttccttgt taagattttt ccttgttaag 26640atctttttaa gagaccttgc
tgtctttttt ttttttttta cttttttttt ccgctttctt 26700ttttgctttt ttcttaggtc
aattttgggg gtgtgtcctg acacttgagg ggcgggtcta 26760aggtgtggct ttcttgggtg
gcttttccat tctgttaaga tttttccttt ttaaggtctt 26820tttaagagac cttgctgcct
tcggtgtctt tttttttttt tacttttcca ttctgacttt 26880ctctgtctct ctcgttgggg
cctgtcttag atcggatggg gcgtgttctc acactttagg 26940ggcgggtcta agggaagagg
ggtgtggtcc gacacttttt atttaattct ttttttctcc 27000gctttcttgg gtggcttttc
cattctgact ttctgtctct ctcagtgggg cgtgtcttag 27060cgtgtcagaa ggggcgtggt
ctaatacttt gggggcgtgt ctcagagcag gaggggtgtg 27120gtctggcact ttagggcgtg
tcctgacact taaggggcgg gtctaaggga agaggggtgt 27180ggtctggtct gatacttttt
tttaaattcc gctttcttgg gtggcttttc cattctgtct 27240ctccctctca gtggagacag
tggagcgtgt cttagcccag aaggggcgtg gtctaatact 27300ttgggggcgt gtctcagagc
aggaggggtg tggtctggca ctttttttta attctttttt 27360tcctctgctt tcccattctg
actttctctg tccctccctc tcagtcgggc gtgtcttagc 27420ccagaagggg cgtggtctaa
tacttatttt tccttttttt accttttttc ccgctttctt 27480gggtggcttc cattctgacc
ttctctctct ctctttctct ctctctctct cgttagcgcg 27540tgtcctgaca cttaaggggc
gggtctaagg gaagaggggt gtggtctgac actttttaag 27600atttttcctt tttaaggtct
tttaagagac ttttcttttt tttttacttt ttttttttcg 27660ctttcttggg tggcttttcc
attctgactt tctctgtccc tctctctcag cccagaaggg 27720gcgtggtctt agacaggaag
gggtctcatc tcgcactttg ggggcctttg ggggcgtgtc 27780tcagagcagg aggggtgtgg
tctgacgctt taggggcgtg tcttaaaccg ggaggggtgt 27840ggtctgacac ttttttaaaa
acttttcctt tttttccgct ttcctgggtg gattttccat 27900tctgactttc tctgtctctc
ccatttaggg tttttttttt tggtctcact attctcatca 27960cactctctgt ctggggatgg
caggtaggga ggaaggggcg tggtctcacg ctttagaggc 28020gggtcttaca ctgggagggg
tctgaagatg gccttctttt taaactctca tctctgccac 28080agaaggctgt gcttccttcc
tttactcttt ggaggcagga aggaaggaag ggccctggtc 28140tcacgcttta ggggcgttct
ttacattttc tttaacgtcc ctgtcttttc tgttccgtct 28200gtcgcagaag gaagacacac
acacatctgc atatccattt caactgcaat tttattgagg 28260gggacatttc tgtacgcagt
caggccccgt tggcgtgctc cttcctccgt gagaatcgct 28320ccgtcctggc ggcctcggcg
acacgcgcac ctggaaaaga cgggaagaga gggagggggg 28380ggggtcagcg tctgtggacg
ggaccgtggc gactcgctgt ttcagtgtgt gagtgtttgg 28440acaccacgcc ggatttgagt
gtgaggcggc ctcattgtgc caatcatcag ttgcgtgtct 28500gctgcctccg tgtgcagacc
cgaggttcct ctgcatctca ttatgccgct ctgagtctaa 28560tctgaatatc tgggcctccg
tgtgcagacc tgaggttcct ctgcgtctaa tctgaatatc 28620tgggcctccg tgtgcagacc
cgaggttcct ctgcatctca ttatgccgct ctgagtctaa 28680tctgaatatc tgggcctccg
tgtgcagacc cgaggttcct ctgcatctca ttatgccgct 28740ctgagtctaa tctgaatatc
tgggcctccg tgtgcagacc cgaggttcct ctgcatctca 28800ttatgccgct ctgcgtctaa
tctgaatatc tgggcctccg tgtgcagacc cgaggttcct 28860ctgcatctca ttatgccgct
ctgcgtctaa tctgaatatc tgggcctccg tgtgcagacc 28920tgaggttcct ctgcatctca
tcatgccgct ctgagtctaa tctgaatatc tgggcctccg 28980tgtgcagacc cgaggttcct
ctgcatctca tcatgccgct ctgcgtctaa tctgaatatc 29040tgggcctccg tgtgcagacc
tgaggttcct ctgcatctca ttatgccgct ctgagtctaa 29100tctgaatatc tgggcctccg
tgtgcagacc cgaggttcct ctgcatctca ttatgccgct 29160ctgagtctaa tctgaatatc
tgggcctccg tgtgcagacc cgaggttcct ctgcatctca 29220ttatgccgct ctgcgtctaa
tctgaatatc tgggcctccg tgtgcagacc tgaggttcct 29280ctgcatctca ttatgccgct
ctgagtctaa tctgaatatc tgggcctccg tgtgcagacc 29340tgaggttcct ctgcatctca
ttatgccgct ctgagtctaa tctgaatatc tgggcctccg 29400tgtgcagacc tgaggttcct
ctgcatctca tgccgctctg cgggagtgtc tcattgactg 29460cgtgatcatg caactctgag
cctggtttgt cactgtctct gtctgtctgt ctctctcctg 29520tctctctacc ttaacccaaa
gctcaccctc tccctctgtc tctatatctc tctgtctctc 29580tctctgtctg tccctaactc
tgtctctaac tgtatctctg tctgtctcca actctgacct 29640tctctctgcc tctccgtcac
tgtctctcgg tctctctgtg tctgtctcgt tctctgtgtc 29700tctgtgtctg tctctatata
tctctgtctc ttacttaccc taatcctaaa cctctgtctc 29760tccatctctg tgtctgtctc
tgtctctctg tctctgcgtc tctgtatctc cgtgtctatc 29820tgtgtctctc tgtccctaac
tctgtctccg actctgtctc tctctctgtc tctatctctg 29880tgtctgtctc actgtctgac
tctccgtgtc tctaccttca ccctaaactt aaccctctct 29940gtctctgtct ctatctctgt
ctctctgtct ctgtcgctaa ctctatctct gtctctgtgt 30000ttctctctct atatctctcc
atctgtctct ccatctctgt ctctatctct ctgtgtttgc 30060cagtctccat cgtctgtgtc
tctgtgtctc tctgtctctg tgtctgtctc actttatatc 30120tctctatctt tctgtcttac
tgtctctgtg tctgtttctg tctctctgtc tccctttctc 30180tctgtcagtc tggctctgta
gctctgtctg tttctctatc tctccatcac tgtctccctc 30240tctatctctc tctctctgtt
tctttctgtc tcactgtctc tgtctctatg tctcactctg 30300cctgtctctg actctgtgtc
tctaaatctg tctctctgtc tctgtctgtt tcactttttc 30360tatctctctc tgtctttctg
tctctctgtc tccctttctc tctgtcagtc tggctctgta 30420gctctgtctg tctgtttctc
tgtctctcca tcactgtctc cctctctatc tgtctctctc 30480tgtttctgtc tgtctttcgg
tctcattgtc tctgtctcag tgtctgtctg tctcagtgtc 30540tgtatctctc tgtctcgcag
tctctgtgtc tctgtttctg tctctatctc gctgtctctc 30600tgtctgtctc tctgtctctg
tctctctcta actctgtcta acactgtctc tgtgtctctg 30660tttctgtttt aaccctaacc
ctaacctcac cctaacccta aacctctctg tctctccatc 30720tctgtctctg tgtctctctg
tctctgtctc tccgtgtctc tctaccttta accctaaccc 30780taacctcacc ctaaacttaa
ccctctctgt ctctacaact gtctctatat ctctctgtct 30840gtctctgtgt ctgtctctct
gtctctgtcg ctaactctat ctctctgtct ctgtgtttct 30900ctctctacgt ctgtctctgt
ctctatctct ctgtgtttgc ccgtctccat cgtctctctg 30960tgtctctctg tctgtctctg
tccctaactc tatctctaac tgtatctctc tttctgtgcg 31020tgtctatctt tctttgtctc
tctgtccgtc tccaactctg ttctgcctct cagtctctct 31080gtctctatct gtttgtctct
atatatctct gtctctccgt gtctctctac cttaacccta 31140acctcaccct aaacttaacc
ctctctgtct ctgtgtctgt ctctctgtct ctgtcgctaa 31200ctctatctct gtctctgtgt
ttctctctct atgtctctcc atctctgtct ctatctctct 31260gtctttatct ctctgttttt
gcctgtctcc atcgtctctc tgtgtctctc tgtctttctg 31320cctctgtttc tgtctgtttc
tctgtctctc catcactgtc tccctctcaa tctgtctctg 31380tctctaagtt tctctgtctc
tgtctgtctc tctttctctg tccctccatc tctgtatctc 31440tctgtctcgc ataaccctaa
ccctaaccct atctaaccct aaccctaacc cccctaaccc 31500taatctaacc ctaaccataa
ccctaaccct cctaacccta acctaacccc cctaacccta 31560acctaacccc cctaacccta
accctaaccc taacctaacc cccctaaccc taacctaacc 31620cccctaaccc taaccctaac
ctaacccccc taaccctaac ctaacccccc taaccctaac 31680ctaaccaccc ccctaaccct
aacctaaccc taacctaacc ctaacctaac cataacccta 31740acctaaccct aaccataacc
caaccctagc cctagccaaa acctgtctct ctgtctgtct 31800ctctttcact ctcaggctct
gtctgtctct ctctctctct gactgtttgt ctctctgtct 31860ttctttctct gtccctgtct
gtctgtctgt ctgtctctgt ttgtctctgt ctccctgtct 31920gcctgtctct ctgtttgtct
ctgtctccct gtttgtatgt ctgtctcttt atctctgtct 31980ctgtctctct atctctctat
atctgtatgt ctgtctgtct gaatctgtct ccctgtctgt 32040ctgtctctct gtcactgtct
ctctgtctgt ctctttcact ctcagtttct gtctctctgt 32100ctgtctctgt ttgtctctgt
ctctctgttt ctctgtcttt gtttgtctgt ctctctgtct 32160gtctcactct ctgactctgt
ctctctgtct gtatctctga ctctgtctgt ctctgtctcg 32220ctatctgtcc ttctgactct
ctgtctctct cagactgtct gtccctctgt ctctttgtct 32280gtccctctgt ctctgtctct
ccctgtctgt ctgtctctgt ctcgctgtcc ctttgtctgt 32340ctctctgtct ctgtctgtct
gtctctgtct cgctgtccct ttgtctttct gtctctgtct 32400ctctgactct gtctctgtct
gtctccgttt ccgtctctct gtctgtctgt ctctgtttcg 32460ctgtcccttt gtctttctgt
ctctgtctct gtctctctga ctctgtctct gtctgtctcc 32520gtttccgtct ctctatctgt
ctctctatct gtctcgctgt ctgtgtctgt gtctctctgt 32580ctctgtatct ctgtctctct
agctctgtct gtctccctgt ccctttgtct ctctgactct 32640gtctccattt ctgtctctct
atctgtctgt ctctctatct ctctctgtct gtctctctgt 32700ctctaactct gtctgtctga
ctctctgtct gtctctctgt ctctgtctgt ctgtctcgct 32760gtccctttgt ctgtctctct
gtctctgtct gtatctgtct gtctctaact ctgtctgtct 32820gtgtctgtct gtctgactct
ctgtctgtct atgtcttttt ccctgtctct ctatctctgt 32880ctctctgtgt ctgtctgact
ctctgtctct ctctgtctat gtctttctcc ctgtctctct 32940gtctctgtct gtctctaact
ctgtctgtat gtgcctgtct gtctgactct ctgtatctgt 33000ctgtctctaa ctctgtcggt
ctgtgtctgt ctgtctgact ctctgtctct ctgtctgtct 33060atgtctttct ccctgtcgct
ctgtctgttt gtctctctgt ctctgtctct ctatctctgt 33120ctctctatct ctgtctctct
atctctgtct ctctctcgga ctgtctctct gtctctgtct 33180ctctctctct gtccctatgt
ctgtctctct gtctgtctcg ctgtcccttt gtctgtctct 33240ctgtctctgt ctctaactct
gtctctctgt gtctgtctgt ctgactccct gtctatctgt 33300ctgtctgtct ctctgtctct
gtctctctct cggactgtct ctctgtctct ctgactctgt 33360ctctctgtct ctgtctgtct
ctaactctgt ctgtctgtct gtgtctgtct gactctgtat 33420ctgtctgtct ctaactctgt
gtctgtctgt gtctatgtct ctgtctctct atctctgtct 33480ctctctcaga ctgtctctct
gtctgtctct ctgtgaagta aagataatta gaagtgaagg 33540taattagaga aaagaaaaat
acctcgtctt gaataaaacc aacaacaata aacaacaaca 33600ataaacaatc gcaaggttgc
actgacgtcc tggggccact gggtggcgcc agagcatctg 33660agtgcctcag tgtgcaaatg
tgagcgtcgc attttaatgt ttatgtgaat ttgcatctct 33720gtgtgcctca ttatgcaaat
ctgtgcgagt tccctgggtc ctggttaaag tctctgtgag 33780ttacctgagc gcctcattta
aatggtgcag caccagagca accctctcag tgtgaagccc 33840agacacaaaa cagaaatcaa
ttcaaagatg tttcctttca aaaaattcaa gaaagaattt 33900cacaaaaatt cccctgcatc
ctaatttaaa cctgcacgag tttccaaggt gctgatttaa 33960acctacaagt tccctggtaa
aaacccgggc gtggtggctg agagaaacca agtctgtccc 34020aaagccacca ggcctctaat
ccctacctac cctccagaga cagagccagg tggatctctg 34080agtcccaggc cagcctgctc
tacagagcga gcttagagaa accctttctc ttaaaaacct 34140gaaaagaaac taaaaataaa
aatccaaaaa gaaagaaaca ggcagataaa taatcgttta 34200acctccaaaa aattaaatct
gaaaagtaat cagaaaagaa agaaaatatg ccaaatcttc 34260gaaaaaaaat ctcaaatttc
acagtgacgt tctatctcca cgagtttcac gggttctaat 34320ttaaacctgc acagattccc
tgattcctaa gttaaacctg cacgagtttt ggaaagatca 34380ggaattcaag gcccacacct
aaacatgata aaagcaatct acagcaaacc agtagccagc 34440atcagagtaa atggagagaa
gctggaagca atcccactaa aatcagggac gagacacggc 34500tgcccactct ctccctacct
cttcaacata gtacttgaag tattagccag agcaattcca 34560caacaaaagg agatcaaggg
gatacaaatt ggaaaagagg aagtcaaaat atcacttttt 34620gcagatgata tgatagtata
tataagtgac cctaaaaatt ccaccagaga actcctaaac 34680ctgataaaca gctttggcga
agtagctgga tataaaataa actcaaacaa gtcaatggcc 34740tttctctata caaagaataa
acaggctgag aaagaaatta gggaaacaac acccttctca 34800atagtcacaa atagtataaa
atatctcggc gtgactctaa ctaaggaagt gaaagatctg 34860tatgataaaa acttcaagtc
tctgaagaaa gaaattaaag aagatctcag aagatggaaa 34920gatctcccat gctcatggag
tggcaggatc aacattgtaa aaatggctat cttgccaaaa 34980gcaatctaca gattcaatgc
aatccccatc aaaattccaa ctcaattctt caacgaatta 35040caaggagcaa tttgcaaatt
catctggaat aacaaaaaac ctaggatagc aaaaactctt 35100ctcaagggtt tgaaaaaaaa
atcacaaatg ttgcagtgac gttctatctc catgagtttc 35160acgggttcaa atttaaacct
gcacagattc cctgattcct aatttaaacc tgcacagatt 35220ccctgattcc taatttaaac
ctgcacagag tttccaaggt gctgatttaa acctacaagt 35280tccctggtaa aaacccgggc
gtggtggcag agagaaacca agtctgtccc aaagccacca 35340ggcctctaat ccctacctac
cctccagaga cagagccagg tggatctctg agtcccaggc 35400cagcctgctc tacagagcga
gcttagagaa accctttctc taaaaaccta aaaataaact 35460aaaagtaaaa actaaactaa
aataagaata attggggaaa aaaccaagtt tcgcgagcac 35520gggtgtctcg ggggttaaaa
attacaaaat taaaatgttc aacagtcaaa aatacaaaaa 35580taaaaattaa aattaaaact
gaaaagaaaa atgacaaatc ttcaaataaa actcaaatat 35640cgtagtgact ttctatctcc
acgagttttg cgggttctaa tttaaacccg cacaaattac 35700tgggttctaa attaaacctt
taatttcaca ctcaaaaata gaaggtgaag ataattagag 35760aaaagaaaaa tacctagtct
tgaataaaaa catcaataaa aaattgcaag cctgcactca 35820cgtcctgtcg ccactgggtg
gcaccagagc caaagtctca cggtgaagca cagagaacac 35880agatcttgga taaaaaccaa
aaaacagatt ccctgcatcc taatttaaac ctgcacagat 35940tccctgattc ctaatttaat
cccacacgag ttcgcctgca tcctgattta aacctgcaca 36000cattcccagg ttctaaatta
aaccttgaat ttcacactca aaaataaaag gtgaagataa 36060gtcgcaaaaa gaaaaatacc
tagtcttgaa tgaaaacaac aataaaaata cggcaatagc 36120ggcttgacaa cacatctaaa
agctctagaa aaaaggaagc aaactccccc aagaggagta 36180gacagatggc aggaaataat
caaactcagg ggggaaatca accaagtgga aacaagaaga 36240actattcaag gaattaacca
aacgaggagc tggttctttg agaaaatcaa caggatagat 36300aaacccttag ccagactcac
tagagggcac agggacaaaa tcctaatgaa caaaatcaga 36360actgaaaagg gagacataac
aacagatccg gaagaaatcc aaaacaccat cagaaatcaa 36420aacacctgtg cctaaaaacc
aaataataaa aattttttaa agatttgtaa agataaaatt 36480aaaaaaaaat aattagaaaa
aatataaagc attgacaaaa acctcccaaa attggaatgt 36540ttattaaaaa ttacaaaata
aaaatattaa acagtcaaaa atacaaaaat taaaattaaa 36600attaaaactg aaaagaaaaa
taaatgccaa atcttcaaaa aaatctccaa tatctcaggg 36660acattctatc tccacgagct
ttgcggcttc taatttaaac ctgcacgagt ttctctgcac 36720cctaatttaa acctgtctct
ctgtctgttt gtctgtctgt ctctctgtct ccctgtctct 36780ctgtctgtct ctctgttaag
taaagataat tagaagtgaa gataattaga gaaaagaaaa 36840atacctcgtc tttgaagaaa
accaacaata aacaatcgca aggttgcatg acgtcctgtg 36900gccactgggt ggcgccagag
catctgagcg cctcagtgtg caaatctgag cgttgcattg 36960taaagtttct gcaaatttgc
atctctgtga gcctcattat gcaaatctgt gcgagctccc 37020tgggtcctgg ttaaagtctc
tgtgagttac ctgagcgcct catttaaatg gtggagcacc 37080agagacaaaa caaaaatcaa
ttcaaagagt cagagagagg ctcatctccc tacacttcta 37140caggctcaaa gggagcaggg
gacgcggacc tgagacgccg cctgcccggg acgccactga 37200ggaagccaca cccgccgtcg
ggagcccggg ctgggattcg ggtcccagat tcgtccccat 37260gaggcagaga aggtagggag
gcgggggaca gagagatgac agagacccga gctgcggggg 37320ccacggactc gggcttggtc
cccgggtgga agaaagtgga agaaggaagg agaagggcgg 37380ggacagagag acagacagaa
acctgcatga gtttccaagg tgctgattta aacctacaag 37440ttcccctggt aaaaatccgg
taaaaaaagc atttgacaag atccaacacc cattcatgat 37500aaaagtcttg gaaagatcag
gaattcgagg cccacaccta accatgataa tagcaatcta 37560cagcaaacca ggagccaaca
tcaaagtaaa tggagagaag ctggaagcaa tcccactaaa 37620atcagggacg agacacggct
gcccactctc tccctacctc ttcaacatag tacttgaagt 37680cctagccaga gcaattccac
aacaacagga gatcacagtc accaggcctc tggtccctgc 37740cctcgagaga gggacagagc
caggtggatc tctgagtccc aggccagcct gctctacaga 37800gcgagcttag agaaaccctt
tctctaaaaa cctaaaaaga aactaaaagt aaaaactaaa 37860ctaaaataag aataattggg
gaaaaaaaca agtctcgcga gcacgggtgt ctcggggctt 37920aagcagcaag aaagcaagtc
tgcgaagatc caaaaattaa aatccaaaaa gaaagaaaca 37980ggcaggtgaa tcaatgttta
acctccaata aattaaaagt gaaaactaat cagaaaagga 38040aaaaatatgc caaatcttcg
aaaaaaaatc tcaaatgtcc acgagtttcg cgggttctaa 38100tttaaacctg cacagattcc
ctgattccta atttaaacct gcacagattc cctgattcct 38160aatttaaacc tgcacagatt
ccctgatttc taatttaaac ctgcacgagt ttgcaaggtg 38220ctgatttaaa cctacaagtt
cccctggtaa aaatccgggc gtggtggtcc aggccttcca 38280tcccagccat ggggacacag
acgcaggcag atctctgaat ccgaggtcag cctggtctcc 38340agagcacatt gcgggacagc
cagggctaca cagagaaacc ctgtggctaa aaaccaaata 38400ataaattttt tttaaagatt
tataaagata aaatttaaaa aataattaga aaaaaatata 38460aagcattgaa aaacgctcca
agaatggaat gtttatttaa aaattacaaa attaaaatgt 38520tcaacagtca aaaatacaaa
aattaaaatt aaaactgaaa agaaaaataa atgacaaatc 38580ttcaaataaa actccaatct
cgcagtgaca ttctatctcc acgagttttg caggtcctaa 38640tttaatccca cacgagttcg
cctgcatcct gatttaaacc tgcacaaatt cccatcttct 38700aaattaaacc ttgaatttca
cacttaaaaa caaaaggtga agataagtag cgaaaagaaa 38760aatacctagt cttgaatgaa
aacaacaata aaaaaacggc aatagcggct tgacaacaca 38820tctaaaagcc ctagaaaaaa
ggaagcaaac tcccccaaga ggagtagaca gatggcagga 38880aataatcaaa ctcaggggtg
aaatcaacca agtggaaaca agaagaacta ttcaaggaat 38940taaccaaacg aggagctggt
tctttgagaa aatcaacaag atagataaac ccttagccag 39000actcactaga gggcacaggg
acagtatcct aattaagaaa atcagaactg aaaagggaga 39060cataacaaca gatccggaag
aaatccaaaa caccatcaga aatcaaagca cctgtgccta 39120aaaaccaaat aataaaattt
ttttaaagat tggtaaagat aaaattaaaa aaaagtaatt 39180agaaaaaata taaagcattg
acaaaacccc acaaaattgg aatgtttatt taaaaattac 39240aaaataaaaa tattcaacag
tcaaaaattc aaatttaaga ttaaaattaa aattaacatt 39300ctaaactcat ctccatgagt
tttgcgggtt ctaatttaaa cctgcacgag tttctctgca 39360ccctaattta aacctgtctc
tctatctgtc tctctctctg ttaagtaaag atatttagaa 39420gtgaagataa ttagagaaaa
gaaaaatacc tcctcttgaa taaaaccaac aataaaaaat 39480cgcaaggttg cagtgacgtc
ctgtggccac tgggtggcgc cagagcatct gagcgcctca 39540gtgtgcaaat ctgagagtcg
cattttaaag tttctgcaaa tttgcatctc tgtgagcctc 39600attatgcaaa tctctgtgag
ttacctgagc gcctcattta aatggtggag caccagagca 39660accctctcag tgtgaagccc
agacacaaaa cagaaatcaa ttcaaagagt cagagagagg 39720ctcatctccc tacacttcta
caggtgcaaa gggagcaggg gacgcggacc attatataaa 39780caaactcaaa ggcaaaaacc
acatgatcat caacatgata aaagcaatct acagcaaacc 39840agtagccaac atcagagtaa
atggagagac gctggaagca atcccactaa aatcagggac 39900gagacacggc tgcccactct
ctccctacct cttcaacata gtacttgaag tattagccag 39960agcaattcca caacaacagg
agatcacagt caccaggcct ctggtccctg ccctcgagag 40020agggacagag ccaggtggat
ctctgagtcc caggccagcc tgctctacag agcgagctta 40080gagaaaccct ttctccaaaa
acctaaaaag aaactaaaag taaaaactaa actaaactaa 40140aataattggg ggaaaaacca
agtctcgcga aaacggtgtc tcggggttaa gccccgagaa 40200agcaagtctg caaagatcca
aaaattaaaa tccaaaaaga aagaaacagg caggtgaatc 40260aatgtttaac ctccaataaa
ttaaaagtga aaactaatca gaaaaggaaa aaatatgcca 40320aatcttcgaa aaaaaatctc
aaatgtccac gagtttcgcg ggttctaatt taaacctgca 40380cagattccct gattcctaag
ttaaacctgc acagattccc tgattcctaa tttaaacctg 40440cacagagttt ccaaggtgct
gatttaaacc tacaagttcc cctggtaaaa atccgggcgt 40500ggtggcccag gccttccatc
ccagccctgg ggacacagac gcaggcagat ctcagaatcc 40560gaggtcagcc tggtctccag
agcacattgc gggacagcca gggctacacc gagaaaccct 40620gtggcaaaaa aaccaaataa
tgaatttttt ttaaagattt gtaaggataa aattaaaaaa 40680aataattaga aaaaatataa
agcattgaca aaacccccca aaattggaat gttaaaaaat 40740tacaaaatat aaatattcaa
cagtcaaaaa ttcaaattta agattaaaat taaaattaaa 40800actgaaaaga aaaataaatg
ccaaatcttc aaaaaaattt ccaatatcac agtgacattc 40860tatctccacg agctttgcgg
gttctaattt aaacctgcac gagtttctct gcaccctaat 40920ttaaacctgt ctctctgtct
gtctgtctgt ctgtctctct gttaattaga agtgaagata 40980attacagaaa agaaaaatac
ctcgtcttga agaaaaccaa caataaacaa tcgcaaggtt 41040gcactgacgt cctttggcca
ctgggtggcg ccagagcatc tgagcgcctc agtgtgcaaa 41100tctgagcgtc gcattttaaa
gtttctgcga atttgcatct ctgtgtgcct cattatgcaa 41160atctgtgcga gctccctggg
tcctggttaa aatctctgtg agttacctga gcgcctcatt 41220taaatggagg agcaccagag
acaaaacaga aatcaattca aagattcaga gagaggctca 41280tctccctaca cttctacagg
ctcaaaggga gcaggggacg cggacctgag acaccgcctg 41340cccggggacg tcactgagga
agtcacaccc ctcctgggga gccagggctg ggattcgggt 41400cccagattcg tccccatgag
gcagagaagg tagggaggcg ggggacagag agatgacaga 41460gacccgagct gcgggggcca
cggactcggg cttggtcccc gggtggaaga aagtaaaaga 41520aggatggaga agggcgggga
cagagagaca gacagaaacc tgcacgagtt aacaaggtgc 41580tgatttaaac ctacaagttc
ccctggtaaa aatccgggcg tggtggccca ggccttccat 41640cccagccctg gggacacaga
tgcaggcaga tctctgaatc cgaggtcagc ctggtctcca 41700gagcacattg cgggacagcc
agggctacac agagaaaccc tgtgtctaaa aaccaaataa 41760taaaaatttt taaaatattt
gtaaagataa aattcaaata aaactcaaat atcgcagtga 41820cattctatct ccacgagctt
tgcgggttct aatttaaacc tatacgagtt tctctgcatc 41880ccaatttaaa cctgtttctc
tgtctctctg tctgtctgtt tgtttttttg tttctgtctg 41940tctgtctctg tctgtatccc
tgagggcagg aaataatcaa actcaggggt gaaatcaacc 42000aagtggaaac aagaagaact
attcaaggaa ttaaccaaac gaggagctgg ttctttgaga 42060aaatcaacaa gatagataaa
cccttagcca gactcactag agggcacaga gacaaaatcc 42120taattaacaa aatcagaaat
gaaaagggag acataacaac agatcctgaa gaaatccaaa 42180acaccatcag atccttctac
aaaaggctat actcaacaaa actggagaac ctggatgaaa 42240tggacaaatt tctgcacaga
taccaggtac caaagttgaa tcaggatcaa gttgaccttc 42300taaacagtcc catatcccct
aaagaaatag aagcacttat caaaagtctc ccagcccaaa 42360aaagcccagg accagatggg
tttagtggag agttctatca ggccttcaaa gaagatctaa 42420ttccagttct gaacaaacta
tttcacaaaa tagaagtaga aggaactcta cccaactcat 42480tctatgaagc cacaattact
ctgataccta aaccacagaa agatccaaca aagatagaga 42540acttcagacc aatttcactt
atgaatatcg acgcaaaaat cctcaataaa attctcgcta 42600accgaatcca agaacacatt
aaagcaatca tccatcctga ccaagcctgc tctacagagc 42660gagcttagag aaaccctttc
tctaaaaacc taaaaagaaa ctaaaagtaa aaaccaaact 42720aaaataagaa taattgggga
aaaaaccaag tctcgcgaga acgggtgtct cggggttaag 42780cctggagaaa tcaagtctgc
gaagatccaa aaattaaaat ccaaaaagaa agaaacaggc 42840aggtgaatca atgtttaacc
tccaacaaat taaaactgaa aagtaatcag aaaaggaaaa 42900aatatgccaa atcttcgaaa
aaaaatctca aatgtccacg agtttcgcgg gttctaattt 42960aaacctgcac agattccctg
attcctaagt taaacctgca cagattccct gattcctagg 43020ttaaacctgc acagagtttc
caaggtgctg atttaaacct acaagttccc ctggtaaaaa 43080tccgggcgtg gtggcccacg
ccttccatcc cagccctggg gacacagacg caggcagatc 43140tcagaatccc aggtcagcct
ggtctccaga gcacattgcg ggacagccag ggctacacag 43200agaaaccctg tgtctaaaaa
ctaaataatg aaaatttttt aaagatttgt aaagataaaa 43260taaaaaaaat aattagaaaa
aatataaagc attgacaaaa acccccaaaa ttggaatgtt 43320tatttaaaaa ttacaaaata
aaaatattca acagtcaaaa attcaaattt aagattaaaa 43380ttaaaattaa aactgaaagg
aaaataaatg ccaaatgctc taaaaaatct caaatatcgc 43440agtgacattc tatctccacg
agctttgcag gttctaattt aaacctgcac gagtttctct 43500gcaccctaat ttaaacctgt
ctctctgtct gtctgtctct ctgttaagta aagataatta 43560gaagtgaaga taattagaga
aaagaaaaat acctcttctt gaagaaaggc aacaataaaa 43620aataaaaata ttcaacagtc
aaaaatacaa aagttgaaat taaaattaaa tttaaaactg 43680aaaagaaaaa taaatgccaa
gccttcaaaa aaatctccaa tatcacagtg acattctatc 43740tccacgagct ttgcaggttc
taatttaaac ctgcacgagt ttctctgcac cctaatttaa 43800acctgtctct ctgtctgtct
ctctgtgatg taaagataat tagaagtgaa aataattaga 43860gaaaagaaaa atacctcctc
ttgaataaaa ccaacaataa acaatggcaa ggttgcatga 43920cgtcctttgg ccactgggtg
gcgccagagc atctgagtgc ctcagtgtgc aaatctgaga 43980gtcgcatttt aaagtttctg
caaatttgca tctctgtgag cctcattatg caaatctgtg 44040cgagctccct gggtcctggt
taaagtctct gtgagttacc tgagcgcctc atttaaatgg 44100tggagcacca gagacaaaac
aaaaatcaat tcaaagagtc agagagaggc tcatctccct 44160acacttctac aggctcaaag
ggagcagggg acgcggacct gagacgccgc ctgcccgggg 44220acgccactga ggaagccaca
cccctcctgg ggagccaggg ctgggattgg ggtcccagat 44280tcgtccccat gaggcagaga
aggtagggag gcgggggaca gagagatgac agagacccga 44340gctgcggggg acacggactc
gggcttggtc cccgggtgga agaaagtgga agaaggaagg 44400agaagggcgg ggacagagag
acagacagaa acctgcacga gtttccaagg tgctgattta 44460aacctacaag ttcccctggt
aaaaatccgg taaaaaaagc atttcacaag attcaacacc 44520cattcatgat aaaaagtctt
ggaaagatca ggaattcaag gcccacacct aaacatgata 44580aaagcaatct acagcaaacc
agtagccagc atcagagtaa atggagagaa gctggaagca 44640atcccactaa aatcagggac
gagacaaggc tgcccactct ctccctacct cttcaacata 44700gtacttgaag tattagccag
agcaattcca caacaacagg agatcacagt caccaggcct 44760ctggtccctg ccctcgagag
agggacagag ccaggtgcat ctctgagtcc gaggccagcc 44820tgctctacag agcgagctta
gagaaaccct ttctctaaaa acctaaaaag aaactaaaag 44880taaaaactca actaatataa
gaataattgg ggaaaaaacc aagtctcatg agcacgggtg 44940tctcggggtt aagcccggag
aaagcaagtc tgcgaagatc caaaaattaa aatccaaaaa 45000gaaaaaaaca ggcagataaa
taaacgttta atctccaaaa acttaaatct gaaaagtaat 45060cagaaaggga aaaaatatgc
cgcaacttcg aaaaaaaatc tcaaatatct cagtgacatt 45120ctatctccac gagctttgcg
ggttctaatt taaacctgca cgagtttctc tgcaccgtaa 45180tttcaacctg tctctctgtc
tgtctctctg ttaagtaaac ataattagaa gtgaagataa 45240ttagagaaaa gaaaaataca
gcgtcttgaa tgaaaccaac aataaacaat cgcaaggttg 45300cactgacgtc ctgtggccac
tgggtggcac cagagcatct gagcgcctca gtgtgcaaat 45360ctgagcgtca cgtttaaagt
ttctgcaaat ttgcatctct gtgtgcctca ttatgcaaat 45420ctgtgcgagc tccctgggtc
ctggttaaaa tctctgtgag ttacctgagc gcctcattta 45480aatggtggag caccagagac
aaaacaaaaa tcaattcaaa gagtcagaga gaggctcatc 45540tccctacact tctacaggcg
caaagggagc aggggacgcg gacctgagac accgcctgcc 45600cggggacgtc actgaggaag
tcacacccct cctggggagc cagggctggg attcgggtcc 45660cagattcgtc cccatgaggc
agagaaggta gggaggcggg ggacagagag atgacagaga 45720cccgagctgt gggggccacg
gactcgggct tggtccccgg gtggaagaaa gtggaagaag 45780gaaggagaag ggcggggaca
gagagacaga cagaaacctg cacgagtttc caaggtgctg 45840atttaaacct acaagttccc
ctggtaaaaa tccggtaaaa aaagcatttg acaagatcca 45900acacccattc atgataaaag
ttttggaaag atcaggaatt cgaggcccac acctaaacat 45960gataaaatgc acagattccc
tgcatcctaa tttaaacctg cacagattcc ctgattccta 46020atttacacct gcacagattc
cctgattcct aatttgaacc tgcacagatt ccctgattcc 46080taatttaacc ctgcacagat
tccctgattc ctaatttaaa cctgcacaga ttccctgatt 46140cctactttaa acctgcacag
attccctgat tcctatttaa acctgcacag attccctgat 46200tcctatttaa acctgcacag
attccctgat tcctaattta aacctgcaca gattccctga 46260ttcctaattt aaacctgcac
agattccctg attcctaatt taaacctgca cagagtttcc 46320aaggtgctgt tttaaaccta
caagttcccc tggtaaaaat ccaggcgtga tgtcccacgc 46380cttccatccc agccctgggg
acacagacgc aggcggatct cagaatccga ggtcagcctg 46440gtctccagag cacattgcgg
gacagccagg gctacacaga gaaaccctgt gtctaaaaac 46500caaattataa aaatttttaa
agatttataa agagaaaatt taaaaaataa ttagaaaaaa 46560tgacagtcaa aaatacaaaa
gttaaaatta aaattgaaaa gaaaaataaa tgacaaatct 46620tcaaataaaa ctccaatatc
acagtgacat tctatctcca cgagttttgc aggttctaat 46680ttaatcccac gcgagttcgc
ctgcatccta atttaaacct gcacaaattc ccatgttcta 46740aattaaacct tgaatttcac
actcaaaaat aaaaggcgaa aagaaaaata cctagtctta 46800aatgaaaaca acaataaaaa
acggcaatag cggcttgaca acacatctaa aagctctaga 46860aaaaaaggac gcaaactcac
ccaagaggag tagacagacg gcaggaaata atcaaactca 46920ggggtgaaat caaccaagtg
gaaacaggaa gaactattca aggaattaat caaaggagga 46980gctggttctt tgagaaaatc
aacaggatag ataaaccctt agccagactc actagagggc 47040acagggacta aatcctaatt
aacaaaatca gaaaattagt gcagagatct atcagacctt 47100caaagaagat ctaattccag
ttctgcacaa actattccac aaaatagaag tagaaggaac 47160tctacccaac tcattctatg
aagccactat tactctgata cctaaaccac agaaagatcc 47220agcaaagata gagaagttca
gaccaatttc ccttatgaat atcgacgcaa aaatcctcaa 47280taaaattctc gctaaccgca
tccaagaaca cattaaagca atcatccatc ctgaccaagt 47340aggttttatt ccagggatgc
agggatggtt taatatacga aaatccatca atgtaatcca 47400ttatataaac aaactcaaag
acaaaaacca catgatcatc tcgtcagatg cagaaaaagc 47460atttgacaag atccaacacc
cattcatgat aaaagttttg gaaagatcag gaattcaagg 47520cccacaccta aacatgctaa
aagcaatcta cagcaaacca gtagccaaca tcaaagtaaa 47580tggagagaag ctggaagcaa
tcccactaaa atccaaaaat taaaatccaa aaagaaagaa 47640acaggcagat aaataaacgt
ttaacctcca caaaattaaa gataattaga agtgaagata 47700attagagaaa agaaaaatac
ctcgtcttga ataaaaccaa caataaaaaa atcgcaaggt 47760tgcactgacg tcctgtggcc
actgggtggc gccagagcat ctgagcgcct cagtgtgcaa 47820atctgagcgt cgcattttaa
tgtttatgtg aatttgcatc tctgtgtgcc tcattatgca 47880aatctgtgcg agttccctgg
ctcctagtta aagtctctgt gagttacctg agcgcctcat 47940ttaaatggtg gagcaccaga
gcaaccctct cagtgtgaag cccagacaca aaacagaaat 48000caattcaaag atgtttcctt
tcaaaaagtt caagaaagaa tttcacaaaa attcccctgc 48060atcctaatga gtttccaagg
tgctgattta aacctacaca agttccccgg taaaaacacc 48120ggcgtggtgg ctgagagaaa
ccaagtctgt cccaaagcca ccaggcctct aatccctacc 48180taccctccag agacagagcc
aggtggatct ctgagtccga ggccagcctg ctctacagag 48240cgagcttaga gaaacccttt
ctctaaaaac ctaaaaagaa actaaaaata aaaactcaac 48300taaaataaga ataattgggg
aaaacagcaa gtctcgcgag cacgggtgtc ttggggttaa 48360gcctggagaa atcaagtctc
tgaagatcca aaaattaaaa tccaaaaaga aagaaacagg 48420cagataaata aacgtttaat
ctccaaaaac ttaaatctga aaagtaatca gaaagggaaa 48480aaatatcctg aaacttcgga
aaaaaatctc aaatgtcgca gtgaagttct atctccacga 48540gttttgcggg ttctaattta
aacctgcaca gattccctga ttcctaattt aaacctgcac 48600gagtttccaa ggtgctgatt
taaacctaca agttcccctg gtaaaaatcc gggcgtgatg 48660tcccacgcct tccatcccag
ccctggggac acagacgcag gcagatctca gaatccgagg 48720tcagcctggt ctccagagca
cattgcggga cagccagggc tacaccgaga aaccctgtgt 48780ctaaaaacca aataataaaa
attttaaaga tttataaaga taaaattaaa aacaaataag 48840tagaaaaaaa tataaagcat
tgatattgac aaaacccccc aaaattggaa tgcttattaa 48900aaaattacaa aataaaaata
ttcaacagtc aaaaatacaa aaattaaaat taaaattaat 48960ttaaaactga aaagaaaaat
aaatgccaaa tcttcaaaaa aatctcaaat atctcagtga 49020cattctatct cctcgagctt
tgcgggttct aatttaaacc tgcacgagtt tctctgcacc 49080ctaatttaaa cctgtttctc
tgactgtctc tctgttaagt aaagataatt agaagtgaag 49140ataattagag taaagaaaaa
tacctcgtct tgaataaaac caacaataaa caatggcaag 49200gttgcactga cgtcctctgg
ccactgggtg gcgccagagc atctgagcgc ctcagtgtgc 49260aaatctgaga gtggaatttt
aaagtttcta caaatttgca tctctgtgtg cctcattatg 49320caaatctgtg cgagtttcct
gggtcctggt taaaatctct gtgagttacc tgagcgcctc 49380atttaaatgg tggagcacca
gagcaaccct ctcagtgtga agcccagaca caaaacagaa 49440atcaattcaa agatgtttcc
tttctaaaaa ttcaagaaac aatttcacaa aaattcctga 49500gagaaaccaa gtctgtccca
aagccaccag gcctctaatc cctacctacc ctccagagac 49560agagccaggt gcatctctga
gtccgaggcc agcctgctct acagagcgag cttagagaaa 49620ccctttctct aaaaacctaa
aaagaaacta aaaataaaaa ctcaactaaa ataagaataa 49680ttgaggacta aaccaagtct
cgcgagcacg ggtgtctcag ggttaagcct ggagaaagca 49740agtctctgaa gatccaaaaa
ttaaaatcca aaaagaaaga aacaggcaga taaataaacg 49800tttaacctcc acaaaattaa
agataataag aagtgaagat aattagagaa aagaaaaata 49860cctcgtcttg aagaaaacca
acaataaaca atcgcaaggt tgcagtgacg tcctgtggcc 49920actgggtggc gccagagcat
ctgagcgcct cagtgtgcaa atctgagcgt tgcattttaa 49980agtttctgca aatttgcatc
tctgtgtgcc tcattatgca aatctgtgcg agctccctgg 50040gtcctggtta aagtctctgt
gagttacctg agcgcctcat ttaaatggtg gagcaccaga 50100gacaaaacag aaatcaattc
aaagagtcag agagaggctc atctccctac acttctacag 50160gcgcaaaggg agcaggggac
agggacctga gacgctgcct gcccggggac cccactgagg 50220aagccacacc cctcctgggg
agcccgggct gggattcggg tcccagattt gtccccatga 50280ggcagagaag gtagggagat
gggggacaga gagatgacag agacctgagc tgcgggggcc 50340acggactcgg gcttggtccc
cgggtggaag aaagtggaag aaggaaggag aagggcgggg 50400acagagagac agacagaaac
ccggggacag cgagacacac ggaagccggg atggtgagtc 50460tcgttcgcat gcagactcgg
gcttggtccc aggtgagaaa aaggaagcag gaagcaggga 50520gaaccaggac agggggacag
acagatgcag agaaccgagc tgatttcaaa aattcaaaac 50580aaaaaaccct gtctctaaaa
aaccaaaaga aaaaaattac aaaatagata tcccggccgg 50640gcgtcgtggc gcccgcacgc
cttctatccc agccctcggg agtcagaggc agggggattg 50700ctgagttgga ggccagcctg
gtctacagcc tgagctccag gacagccagg gctacacaga 50760gaaaccctgt ctcgaaaaac
caaaaagaaa tcccaagcct taaaaacgta aaaacctcag 50820aaattggagc gttgcagtaa
cgtcctgttt ggaaaaatta ccaagccttc aagaagaccc 50880gtgacgtcgc agggaagtcc
tgcggccacc gggcggcgtc ttgggactga gtcacactgg 50940gaggtcgcgt tgtccacctg
ggtccctgag cccctgtggg cggctgtgcg tgtcagtggt 51000cggcgctgcg tgtcctacct
gacggcgtgc gtgcgtccgt ccgtccgtcc agcggggcga 51060gggtcggtgg cacatacatc
ttgaccacgg cgggtgaaca tcttgaccgc ggcggctcgt 51120ccgtgtctgc gtggcgggtg
cggcgggtcc tgcggatgcg tgtgcctggc ctgcctgccg 51180tgtgtgccgt gtgtgccgcg
tgtgcctggg cgggcgcggg gcccgcgtgt gtcctgtgtg 51240ctgtggtggg tgcagcggtg
cggtcggcgc aggcttccta ccttgtggag tccgtccgtc 51300cgtcctgtgg ggatggcaga
gacatcttga ccacggcgtc cgcttctacg tgtgtgcttt 51360cgtgggtgac atcactgtgg
gcggcggcag tgaccggtgg acgctggcgt gggatccagg 51420tccataaaca gagaaacacg
tgttagactt tcaaatcaca caacaaaaaa aataataaat 51480aaaaaaaatt ggagtcgggc
gtggtggtgc acacctttca tcccagcact cgggagccgg 51540agacaggcag atttctgagt
tggaggccag cctggtctac aaagtgagtt ccaggacagc 51600cagggctaca cagagaaacc
ctgttcgaaa aaccaaaaaa ctaaaataaa ataaaataaa 51660aataataaga ataattaggg
aaaaaaaacc atagccaggg ctataaagag aaaacctgtc 51720ttgaaaaacc aaaaagtaaa
ataaaaataa aataaaataa aataaaaata agaataaaaa 51780ttagaataat taggaaaaaa
atacaaaggt ctgaagttca aatcccagca accacgtggt 51840ggctcacaac cacccgtaac
gagatctgac tccctcttct cgagtgtctg aagacagcta 51900cagtgcactt acatacaata
aataaacatc ttttaaaaag agcaaaaaaa cttttaaaaa 51960aagcaaaaaa aaaaaaaaaa
aaaaaaaaaa attggagggt tgcagtgaca atccgtggcc 52020acaaggtggc gcccctgagc
aagtctacat tgccaggctg aagcacagtc taaccactgt 52080gcttaaagtc tctaaccact
ttctccaaaa agtaaaaatt aaattaaaaa ttaaaaataa 52140aaaagagaat aattagggaa
aaaaccatag ccaggactat aaagagaaac cctgtcttga 52200aaaacgaaaa aaaaaatact
gaaataaaaa agaataaaaa taaaacattt cgacgctgcc 52260ctgacatact cccgccactg
gcggacgcgc cccagccgag tgggcgtgtt gggatgaaac 52320ccagagactc caagtctggg
aagaaaaaaa accctaaaat atccaatcaa tagatcaata 52380actccagcaa taaacgcatc
agtgcctttg aaaggctcag acatcagaga ttaactacag 52440ctcccagcat gccccggggc
ccacttcctg ctgcagacgc ccctcagagt gaaacccata 52500gagaaccatg gacccccgca
gggcagtaaa actcccagca tgcctcgggg ctgagtcccc 52560accactcaca ccagagcagc
cctgtcagag tgaagggcag acccgcccat tcttaaaaca 52620acaacaacaa caggggctgg
cgagatggct cagtgggtaa gagcccccga ctgctcttcc 52680agagctctga agttcaaatc
ccagcgacca cgtggtggct cacaagcacc cgtaacgaga 52740tctgacgccc tcttctcagt
gtctgaagac agctacagtg cacttacata caataaataa 52800acatctttta aaaagagcaa
aaaaaaaact tttaaaaaaa gcaaaaaaaa acccagaaaa 52860acaagaaaca attggagggt
tgcagagcct atgtctcctc taagcaccag ctctaagtct 52920ctaaccacca ggctacagtg
tcctgtaacc accaggcata agtcgctgac caccaggcta 52980cagtgtcctg taaccaccag
gcataagtct ctaaccacca ggctacagtg tcctctaacc 53040cccagctcta agtcgctgac
caccaggcta cagtgtcctg taaccgccag ctctaagtcg 53100ctgaccacca ggctacagtg
tcctgtaacc gccaggcata agtcgctgac caccaggcta 53160cagtgtcctg taaccgccag
gcataactcg ctgaccacca ggctacagtg tcctgtaacc 53220gccagctcta agtctctaac
caccaggcta cagtgtcctg taaccgccag gcataagtcg 53280ctgaccacca ggctacagtg
tcctgtaacc gccaggcata agtcgctgac caccaggcta 53340cagtgtcctg taaccaccag
gcataagtct ctaaccacca ggctacagtg tcctgtaacc 53400accaggtata agtctctaac
cgccaggcta cagtgtcctg taaccgccag gcataagtct 53460ctaaccacca ggctacagtg
tcctgtaacc gccaggcata agtcgctgac caccaggcta 53520cagtgtcctg taaccgccag
gcataagtct ctaaccacca ggctacagtg tcctgtaacc 53580gccagctcta agtctctaac
caccaggcta cagtgtcctg taaccaccag gcataagtcg 53640ctgaccacca ggctacagtt
tcctgtaacc gccaggcata agtctctaac caccaggcta 53700cagtgtcctc taacccccag
ctctaagtcg ctgaccacca ggctacagtg tcctgtaacc 53760gccagctcta agtcgctgac
caccaggcta cagtgtcctg taaccgccag gcataagtcg 53820ctgaccacca ggctacagtg
tcctgtaacc gccagctcta agtctctaac caccaggcta 53880cagtgtcctg taaccgccag
gcataagtcg ctgaccacca ggctacagtg tcctgtaacc 53940accaggtata agtctctaac
cgccaggcta cagtgtcctg taaccgccag gcataagtct 54000ctaaccacca ggctacagtg
ccctgtaacc accaggcata agtcgctgac caccaggcta 54060cagtgtcctg taaccgccag
gcataagtct ctaaccacca ggctacagtg tcctctaacc 54120cccagctcta agtcgctgac
caccaggcta cagtgtcctg taaccgccag ctctaagtcg 54180ctgaccacca ggctacagtg
tcctgtaacc gccaggcata actcgctgac caccaggcta 54240cagtgtcctg taaccgccag
gcataagtcg ctgaccacca ggctacagtg tcctgtaacc 54300gccaggcata actcgctgac
caccaggcta cagtgtcctg taaccgccag ctctaagtct 54360ctaaccacca ggctacagtg
tcctgtaacc gccaggcata agtcgctgac caccaggcta 54420cagtgtcctg taaccgccag
gcataagtcg ctgaccacca ggctacagtg tcctgtaacc 54480gccaggcata agtctctaac
caccaggcta cagtgtcctg taaccgccag gcataagtct 54540ctaaccacca ggctacagtg
tcctgtaacc gccaggcata agtctctaac caccaggcta 54600cagtgtcctg taaccaccag
gcataagtcg ctgaccacca ggctacagtg tcctgtaacc 54660gccaggcata agtctctaac
caccaggcta cagtgtcctg taaccgccag gcataagtct 54720ctaaccacca ggctacagtg
tcctgtaacc accagctcta agtcgctgac caccaggcta 54780cagtgtcctg taaccgccag
gcataagtct ctaaccacca ggctacagtg tcctgtaacc 54840accaggcaca agtcgctgac
caccaggcta cagtgtcctg taaccgccag ctctaagtct 54900ctaaccacca ggctacagtg
tcctgtaacc gccaggcata agtctctaac caccaggcta 54960cagtgtcctg taaccaccag
ctctaagtcg ctgaccacca ggctacagtg tcctgtaacc 55020gccaggcata agtctctaac
caccaggcta cagtgtcctg taaccaccag gcacaagtcg 55080ctgaccacca ggctacagtg
tcctgtaacc gccagctcta agtcgctgac caccaggcta 55140cagtgtcctg taaccaccag
gcataagtcg ctaaccacca ggctacagtg tcctgtaacc 55200gccaggcata agtctctaac
caccaggcta cagtgtcctg taaccgccag gcataagtcg 55260ctgaccacca ggctacagtg
tcctgtaacc gccaggcata agtcgctgac caccaggcta 55320cagtgtcctg taaccaccag
gcataagtcg ctgaccacca ggctacagtg tcctgtaacc 55380accaggcata agtctctaac
caccaggcta cagtgtcctg taaccgccag gcataagtct 55440ctaaccacca ggctacagtg
tcctgtaacc accaggcata agtcgctgac caccaggcta 55500cagtgtcctg taaccaccag
gcataagtct ctaaccacca ggctacagtg tcctgtaacc 55560accaggcata agtctctaac
caccaggcta cagtgtcctg taaccgccag gcataagtct 55620ctaaccacca ggctacagtg
tcctgtaacc gccaggcata agtctctaac caccaggcta 55680cagtgtcctg taacctccag
gcataagtcg ctgaccacca ggctacagtg tcctgtaacc 55740gccaggcata agtcgctgac
caccaggcta cagtgtcctg taaccaccag gcataagtcg 55800ctgatcacca ggctacagtg
tcctgtaacc gccagctcta agtcgctaac caccaggcta 55860cagtgtcctg taaccaccag
ctctaagtct ctaaccacca ggctacagtg tcctgtaacc 55920accagctcta agtctctaac
caccaggcta cagtgtcctg taaccgccag gaataagtcg 55980ctgaccacca ggctacagtg
tcctgtaacc gccaggcata agtcgctgac caccaggcta 56040cagtgtcctg taaccgccag
gcataagtcg ctgaccacca ggctacagtg tcctgtaacc 56100accaggcata agtcgctgac
caccaggcta cagtgtcctg taaccaccag gaataagtct 56160ctaaccacca ggctacagtg
tcctgtaacc accaggcata agtctctaac caccaggcta 56220cagtgtcctg taaccgccag
gcataagtcg ctgaccacca ggctacagtg tcctgtaacc 56280accaggaata agtctctaac
caccaggcta cagtgtcctg taaccaccag gcataagtct 56340ctaaccacca ggctacagtg
tcctgtaacc accaggcata agtctctaac caccaggcta 56400cagtgtcctc taacccccag
ctctaagtcg ctgaccacca ggctacagtg tcctgtaacc 56460gccaggcatg agtcgctgac
caccaggcta cagtgtcctg taaccgccag gcataagtcg 56520ctgaccacca ggctacagtg
tcctgtaacc gccaggcata agtcgctgac caccaggcta 56580cagtgtcctg taaccaccag
gcataagtcg ctgaccacca ggctacagtg tcctgtaacc 56640tccaggcatc agtcgctgac
caccaggcta cagtgtcctg taaccgccag gcatcagtcg 56700ctgaccacca ggctacagtg
tcctgtaacc gccagacata agtcgctgac caccaggcta 56760cagtgtcctg taaccgccag
gcataagtct ctaaccacca ggctacagtg tcctgtaacc 56820gccaggcata agtctctaac
caccaggcta cagtgtcctg taaccaccag gcataagtcg 56880ctgaccacca ggctacagtg
tcctgtaacc accaggcata agtctaacca ccaggctaca 56940gtgtcctgta accaccaggc
ataagtctaa ccaccaggct acagtgtcct gtaaccgcca 57000ggcataagtc tctaaccacc
aggctacagt gtcctgtaac cgccaggcat aagtctctga 57060ccaccaggct acagtgtcct
gtaaccgcca ggcataagtc tctaaccacc aggctacagt 57120gtcctgtaac ccccagctct
aagtcgctga ccaccaggct acagtgtcct gtaaccacca 57180ggcataagtc gctgaccacc
aggctacagt gtcctgcaac cgccaggcat aagtctctaa 57240ccaccaggct acagtgtcct
gtaaccgcca ggcataagtc gctgaccacc aggctacagt 57300gtcctgtaac caccaggcat
aagtcgctga ccaccaggct acagtgtcct gtaaccgcca 57360ggcataagtc tctgaccacc
aggctacagt gtcctgtaac cgccaggcat aagtctctga 57420ccaccaggct acagtgtcct
gtaaccgcca ggcataagtc gctgaccacc aggctacagt 57480gtcctgtgac caccaggcta
cagtgtcctg taaccgccag gcataagtct ctaaccacca 57540ggctacagtg tcctgtaacc
accaggcata agtcgctgac caccaggcta cagtgtcctg 57600taaccaccag gcataagtcg
ctaaccacca ggctacagtg tcctgtaacc accaggcata 57660agtctctaac caccaggcta
cagtgtcctg taaccgccag ctctaagtcg ctgaccacca 57720ggctacagtg tcctgtaacc
accaggcata agtcgctgac caccaggcta cagtgtcctg 57780taactgccag gcatgagtcg
ctgaccacca ggctacagtg tcctgtaacc accaggcata 57840agtcgctgac caccaggcta
cagtgtcctg taaccgccag gcataagtct ctaaccacca 57900ggctacagtg tcctgtaacc
gccaggcata agtctctaac caccagccta cagtgtcctg 57960taaccaccag gaataagtcg
ctgaccacca ggctacagtg tcctgtaacc gccaggcata 58020agtctctaac caccagccta
cagtgtcctg taaccaccag gaataagtcg ctgaccacca 58080ggctacagtg tcctgtaacc
gccaggcata agtctctaac caccaggcta cagtgtcctg 58140taaccgccag gcataagtcg
ctgaccacca ggctacagtg tcctgtaacc gccaggcata 58200agtcgctgac caccaggcta
cagtgtcctg taaccgccag gcatgagtct ctaaccacca 58260ggctacagtg tcctgtaacc
gccaggcata agtcgctgac caccaggcta cagtgcactt 58320acatagaata aataaacatc
tttaaaaaaa agcaaaaaaa aaattttaaa aaaagcaaaa 58380aaaaaaaaac caaaaaaacc
accaattgtt gcgctggcat aaacctccca cggcagaaat 58440gaaagctaaa cacaccgtgt
gccgttgccg tgacgtcccg tgcgccccgg gcggcgcccc 58500agagcccgcg tccagcacaa
actctcaaaa attaaaaata cgaaatgctt gggaaaaaaa 58560accaagcctt caagaagacc
cgtgacgtcg cagggacgtc ccgcggccac cgggcggcgt 58620ctcgggaccg agccacactg
ggaggtcgcg gtgtccaccc gggtccctga gcccctgtgg 58680gcggccgtgc gtgtcagtgg
tcggcgctgc gtgtcctacc tgacggcgtg cgcgcgtccg 58740tccgtccgtc cagcggggcg
agggtcggtg gcacatacat cttgaccgcg gcgggtgaac 58800atcttgaccg cggcggctcg
tccgtgtctg cgtggcgggt gcgggtcctg cggatgcgtg 58860tgcctggcct gcctgccgtg
tgtgccgtgt gtgccgcgtg tgcctgggcg ggcgcggggc 58920ccgcgtgtgt cctgtgtgct
gtggtgggtg cggcggtgcg ctcggcgcag gcttcctacc 58980ttgtggagtc cgtccgtgcg
tccgtgcgtc cgtgcgtccc gtgggcatgg cagagacatc 59040ttgaccgcgg cgtccgcttc
tgcgcgtgtg ggtgacgtcg ctgggggcgg cggccgtgac 59100cggcggaggc tgaacagaga
aacacgggtt agactttcca ttcacgccca cagaaaaact 59160tacaacaaaa tttataaatt
aaattaaatt aagaattaaa ttacaaataa ggacaagaat 59220aattagggca gaaaccatag
ctgcggctaa aagagaaacc ctgtctccaa aatcaaaaat 59280taaaattaaa aaataaacaa
aaatgaaaag gagaataatt acggaaaaaa cggtagccaa 59340ggctataaag agaaatcctg
tctggaaaag taaaaattaa aaataaaaca aaaaaaataa 59400ttagtgaaaa atccacagcc
aggtctatac agagaaaccc tgtcttaaaa aaaccaaaat 59460taaaaaaaaa taaaccaaaa
tgaaaataag aataattagg gaaaaaacgg tagccaaggc 59520tctaaagaga aatcctgtgt
gaaaaagtaa aaattaaaaa taaagctaaa agaaataatt 59580agtgaaaaac ccacagccag
gactatacag agaaacgcgt gctttaaaac atggcgctgc 59640aactcccagc atgcctcggg
gccgccttcc cgccactcac tctgaaagcc catagagaac 59700cattgactac ggcaggacta
caactcccag catgcctcgg ggccgccttc ccgccactca 59760ctctgaaagc ccatagagaa
ccattgacga cggcaggact acaactccca gcatgcctcg 59820gggccgcctt cccgccactc
actctgaaag cccatagaga accattgact acgcactaca 59880agtcccagca ttcccggctc
cgaccgagcc ttctcttccc gccgcagaca ggaagtgcct 59940ccatcttaag tccgcacggt
cggatcgagt ttaaaaaagc ccccaaatgc cccccagacc 60000cccccagacc ccaattgtac
gtcacggttc tgcagccggg gccccgggcg ggcgggcgcg 60060gtggcggctg gggatcccgg
gcgggcgcgc gggcgggcct cacgtcacgc ggcggcggcg 60120gcggcggcgg gaaccgggga
ccctggaggc ggctgcgggc cgagcaagcc ccgtccgtgc 60180gcggccgagc ctgtggggaa
gagagcgggg ctgagacgga ggcaggggga tggccgggag 60240tgagcggaga aggcgggagc
tcgggcggga cgcggcccgg ggccgcactc acctctcatg 60300gcggcaggcg cggtccgctg
ctcccgcccg cccgcccgcc cgcgcgggga aggccgggga 60360ggccgaggcg gcggcggcgg
aggcccgggg aggcggaggg gagccggcgg ggccgtgcgc 60420gggcggcgga ggccgagtcc
gatcgcgggg agacggcggg gagccgggga cgtccgcgga 60480gctgcgagca catggcgatc
ccaggagcga gtgtgcaggg acggccgcgg cgcctgcgcg 60540gggggcgggg ccggggcggc
ggccgcgaga gacgggcggc ggcggcggcc aatcgggagc 60600ccggggcccg cgtgacgtca
ccccgcggga ctcgggaggc cgcggtgacc ccgcccctgg 60660cgggagcggc tctgtgtctc
ctccctgtcg ccatggcgac gcaggcggcc aggcagcccc 60720cgggctgggg aagggcttgg
ttcccgccct gccagcacag gccggcctgc catctcagtc 60780atccccctgc ctcagctctg
cccctgggat tacaggcctg ggcgggtccc tgcctggggc 60840cctgaggctc atgaacccca
gagctgaatc cctgcatcca aacaaagcca agcaccccca 60900aactcgtaac tgtgtgaggc
tgggggatga ccatgagtga gtgtgtgtga ataaaataat 60960aaaataaata aaatgcaaac
acagcaccag ggcaggcggc ccagtgtgtg tgtcacaact 61020gtgtgactgt gtgaggcagg
gggatgtctg tgagtgattt tctggggcag ggtgatgatg 61080ctgattgaat gtgtgagaca
ggggcatgaa aatgagacag gggatgaagc tgagtgaatg 61140tatgaggcag gggtttaact
gtgagtgagt ttctgaggca gggggatgac agtgagtgaa 61200tttctgaggc agggggatga
ctgtgagtga ttttctgagg cagggggatg actgtaagtg 61260attttttgaa gcagggagat
gacagtgagt gaatttctga ggcaggggga tgactgtgag 61320tgattttctg aggcaggggg
atgactgtaa gtgatttttt gaagcaggga gatgactgtg 61380agtgattttc tgaggcaggg
ggatgactgt gagtgatttc tgctgattga atgtgtgagg 61440caggggcatg aaaatgaggc
aggagatgaa gctgagtgaa tgtatgaagc aggggttaac 61500tgagtgagtt tctgaggcag
ggggatgact tttagtgtgt ttctgaggta ggggtttgat 61560gctgagtgac tgtgtgacac
aggagattga ccctgagagg ctgtatgagg cagggggatg 61620ttagtgagtt tctctgtgag
gcagggggat gacagtgagt gattttctga ggcaggggga 61680tgaagcagag taactgtggg
gcagggggat gtggctgtgt gactgtggga tgcaggggaa 61740tgactgtgtg tgattttctg
aggcagaggg ctgactgtaa gtgattttct gaggcagggg 61800gatgactgtg agtgaatttc
tgaggcaggg ggatcgctgt gagtgatttt ctgaggcagg 61860agcatgatgc tgagtgagtg
tctgaggcat agggatgaca gtgagtgatt ttctgacaca 61920gggggatgaa gcagagtaac
tgtgaggcag ggggatgtgg ctgtgtgact gtgtgaggca 61980gggggatgaa tgtgtgtgat
tttctgaggc agagggttga cagtgagtga ttttctgaat 62040catggagatg acagtgagtg
attttctgag gcagggggat gactgtgagt gattttctga 62100ggcaggggga tgaagcagag
taactgtggg gcagggggat gtggctgtgt gactgtggta 62160tgcaggggaa tgactgtgtg
attttctgag gcagagggat gacagtgagt gattttctga 62220ggcagagggc tgactgtgag
tgaatttctg aagcaggttg ctcactgtga gtgattttct 62280ggggcggggg gatcactgtg
agtgaatgta tgaggcaggg ggctgactgt aagtgatttt 62340ctgaggcagg gggatgtctg
tgagtgattt tctgaggcag ggggatgact gtgagtgaat 62400gtatgaggca ggggctgact
gtaagtgatt ttctgaggca gggggatgac tgtgtgtgat 62460tttctgaggc agtgggatga
cagtgagtga ttttctgaca cagggggatg actgtgagtg 62520attttctgag gcagggggat
gactgtgagt gattttctga ggcagaggga tgacagtgag 62580tgattttttg aggcaggggg
ctgactgtaa gtgattttct gaagcagggg gctcactgtg 62640agtgattttc tgaggcaggg
ggatcactgt gagtgaatgt acgaggcagg ggaatgactg 62700tgtgtgattt tctgaggcag
ggggatgact gtaagtgatt ttctgaagca gggggctcac 62760tgtgagtgat tttctgaagc
ggggggatca ctgtgagtca atgtatgagg cagggggatg 62820actgtaagtg attttctgaa
gcagggggct cactgtgagt gattttctga ggcatgggga 62880tcatgtgagt gaatgtatga
ggcacggggc tgactgtaag tgaatttctg aggcaggggg 62940ctgactgtga gtgaatttct
gaggcagggg gatgactgtg agtgaatttc tgaggcaggg 63000ggatgaatgt gagtgtgttt
ctgaggcagg ggaatgttgt gagtgagtgt gtaagtcagg 63060gggatgactg tgagtgattt
tctgggccac ggggatgact gtgtttgagt ctctgaggca 63120gggggctgac tgtaagtgat
tttctgaagc aggggaagag tgtgtttgat tttctgaggc 63180agggggatgg tagtgagttt
ccgtgtgaag cagggggatg actgtgagtg attttctgaa 63240gcagggggat gactgtgagt
gattttctga ggcaggggga tcactgtgag tgattttctg 63300aggcaggggg atgactgtga
ttcattttat gagacaggga gatgactccc tgtgactgtt 63360gaggcagggg cattactgtg
aatgaatttc taaggcagag ggatgactgt gtgtgatttt 63420ctgaggcagt gggatgactg
tgagtgattt tctgaatcat ggagatgaca gtgagtgatt 63480ttctgaggca gggggatgac
tgtgagtgat tttctgaggc agggggatgt ctgtgtgtga 63540ttttctgagg cagagggatg
acagtgagtg attttctgag gcagggggat gaagcagagt 63600aactgtgggg cagggggatg
tggctgtgtg actgtggtat gcaggggaat gactgtgagt 63660gattttctga ggcagaggga
tgactgtgag tgattttctg aggcagaggg ctgactgtga 63720gtgaatttct gaagcagggg
gctcactgtg agtgattttc tggggcgggg ggatcactgt 63780gagtgaatgt atgaggcagg
gggctgactg taagtgattt tctggggcag gggtatgtct 63840gtgagtgatt ttctgaggca
gggggatgac tgtgagtgaa tgtatgaggc aggggctgac 63900tgtaagtgat tttctgaggc
agggggatga ctgtgagtga atgtatgagt caggggctgc 63960ttgtgagtga ttttctgagg
cagggggatg actgtaagtg attttttgaa gcagggagat 64020gacagtgagt gaatttctga
ggcaggggga tgactgtgag tgattttctg aggcaggggg 64080atgactgtaa gtgatttttt
gaagcaggga gatgactgtg agtgattttc tgaggcaggg 64140ggatgactgt gagtgatttc
tgctgattga atgtgtgagg caggggcatg aaaatgaggc 64200aggagatgaa gctgagtgaa
tgtatgaagc aggggttaac tgagtgagtt tctgaggcag 64260ggggatgact tttagtgtgt
ttctgaggta ggggtttgat gctgagtgac tgtgtgacac 64320aggagattga ccctgagagg
ctgtatgagg cagggggatg ttagtgagtt tctctgtgag 64380gcagggggat gacagtgagt
gattttctga ggcaggggga tgaagcagag taactgtggg 64440gcagggggat gtggctgtgt
gactgtggga tgcaggggaa tgactgtgtg tgattttctg 64500aggcagaggg ctgactgtaa
gtgattttct gaggcagggg gatgactgtg agtgaatttc 64560tgaggcaggg ggatcgctgt
gagtgatttt ctgaggcagg agcatgatgc tgagtgagtg 64620tctgaggcat agggatgaca
gtgagtgatt ttctgacaca gggggatgaa gcagagtaac 64680tgtgaggcag ggggatgtgg
ctgtgtgact gtgtgaggca gggggatgaa tgtgtgtgat 64740tttctgaggc agagggttga
cagtgagtga ttttctgaat catggagatg acagtgagtg 64800tttttctgag gcagggggat
gactgtgagt gattttctga ggcaggggga tgaagcagag 64860taactgtggg gcagggggat
gtggctgtgt gactgtggta tgcaggggaa tgactgtgtg 64920attttctgag gcagagggat
gacagtgagt gattttctga ggcagagggc tgactgtgag 64980tgaatttctg aagcaggttg
ctcactgtga gtgattttct ggggcggggg gatcactgtg 65040agtgaatgta tgaggcaggg
ggctgactgt aagtgatttt ctgaggcagg gggatgtctg 65100tgagtgattt tctgaggcag
ggggatgact gtgagtgaat gtatgaggca ggggctgact 65160gtaagtgatt ttctgaggca
gggggatgac tgtgtgtgat tttctgaggc agtgggatga 65220cagtgagtga ttttctgaca
cagggggatg actgtgagtg attttctgag gcagggggat 65280gactgtgagt gattttctga
ggcagaggga tgacagtgag tgattttctg aggcaggggg 65340ctgactgtaa gtgattttct
gaagcagggg gctcactgtg agtgattttc tgaggcaggg 65400ggatcactgt gagtgaatgt
acgaggcagg ggaatgactg tgtgtgattt tctgaggcag 65460ggggatgact gtaagtgatt
ttctgaagca gggggctcac tgtgagtgat tttctgaagc 65520ggggggatca ctgtgagtca
atgtatgagg cagggggatg actgtaagtg attttctgaa 65580gcagggggct cactgtgagt
gattttctga ggcatgggga tcatgtgagt gaatgtatga 65640ggcacggggc tgactgtaag
tgaatttctg aggcaggggg ctgactgtga gtgaatttct 65700gaggcagggg gatgactgtg
agtgaatttc tgaggcaggg ggatgaatgt gagtgtgttt 65760ctgaggcagg ggaatgttgt
gagtgagtgt gtaagtcagg gggatgactg tgagtgattt 65820tctgggccac ggggatgact
gtgtttgagt ctctgaggca gggggctgac tgtaagtgat 65880tttctgaagc aggggaagag
tgtgtttgat tttctgaggc agggggatgg tagtgagttt 65940ccgtgtgaag cagggggatg
actgtgagtg attttctgaa gcagggggat gactgtgagt 66000gattttctga ggcaggggga
tcactgtgag tgattttctg aggcaggggg atgactgtga 66060ttcattttat gagacaggga
gatgactccc tgtgactgtt gaggcagggg cattactgtg 66120aatgaatttc taaggcagag
ggatgactgt gtgtgatttt ctgaggcagt gggatgactg 66180tgagtgattt tctgaatcat
ggggatgaca gtgagtgatt cttttaagca gggggatgac 66240tgtgagtgat tttctgaagc
agggggatga ctgtgagtga ttttctgagg cagggggatg 66300actgtgattc attttatgag
acagggagat gactccctgt gactgttgag gcaggggcat 66360tactgtgaat gaatttctaa
ggcagaggga tgactgtgtg tgattttctg aggcagtggg 66420atgactgtga gtgattttct
gaatcatgga gatgacagtg agtgattttc tgaggcaggg 66480ggatgactgt gagtgatttt
ctgaggcagg gggatgaagc agagtaactg tgaggcatgg 66540ggatgtggct gtgtgactgt
ggtatgcagg ggaatgactg tgtgtgattt tctgaggcag 66600agggatgact gtgagtgatt
ttctggggcg gggggatcac tgtgagtgaa tgtatgaggc 66660agggggctga ctgtaagtga
ttttctgagg caggggtttg tctgtgagtg attttctgag 66720gcagggggat gactgtgagt
gaatgtatga ggcaggggct gactgtaagt gattttctga 66780ggcaggggga tgactgtgtg
tgattttctg aggcagaggg atgacagtga gtgattttct 66840gacacagggg gatgactgtg
agtgattttc tgaggcaggg ggatgactgt gagtgatttt 66900ctgaggcaga gggatgacag
tgagtgattt tctgaggcag ggggctgact gtaagtgatt 66960ttctgaagca gggggctcac
tgtgagtgat tttctgaggc aatggggatc actgtgagtg 67020aatgtatgag gcaggggctg
actgtaagtg attttctgag gcagggggat gactgtgtgt 67080gattttctga ggcagaggga
tgacagtgag tgattttctg acacaggggg atgactgtgt 67140gtgattttct gaggcagagg
gatgacagtg agtgattttc tgacacaggg ggatgactgt 67200gagtgatttt ctgaggcagg
gggctgactg tgagtgaatt tctgaggcag ggggatgact 67260gtgagtgaat ttctgaggca
gggggatgac tgcgagtgat tttctgaggc agggggatga 67320ctgtgggtga atatatgagg
ctgggggttg actgcgagtg agtttctgag gctcccctcc 67380ccccaggccg ctggccgcct
ccatgacccc ctggcgggag cggctctgtg tctcctccct 67440gtcgccatgg cgacgcaggc
ggccaggcag cccccgggct ggggaagggc ttggttcccg 67500ccctgccagc acaggccggc
ctgccatctc agtcatcccc ctgcctcagc tctgcccctg 67560ggattacagg cctgggcggg
tccctgcctg gggccctgag gctcatgaac cccagagctg 67620aatccctgca tccaaacaaa
gccaaacacc ccccaaactc gtaactgtgt gaggcggggg 67680gatgaccatg agtgagtgtg
tgtgaataaa ataataaaat aaataaaatg caaacacagc 67740gccagggcag gcggcccagt
gtgtgtgtca cagctgtgtg actgtgtgag gcagggggat 67800gtctgtgagt gattttctga
ggcaggggca tgactgtgag tgattttatg tgagtgactg 67860ttagtgtttg acgtaggggt
ttgatgctga gtgactgtgt gacacaggag attgaccctg 67920agaggctgtg tgaggcaggg
ggatgttagt gagtttctct gtgaggcagg gggatgactg 67980tgagtgattt tctgaggcag
ggggatgaca gtgagtgatt ttctgacaca gggggatgaa 68040gcagagtaac tgtggggcag
ggggatgtgg ctgtgtgact gtgggatgca ggggaatgac 68100tgtgtgtgat tttctgaggc
agaggactga cagtgagtga ttttctgagg gagggggctg 68160actgtaagtg attttctgag
gcagggggat gtctgtgagt gattttctga ggcaggggga 68220tgactgtgag tgaatgtatg
aggcaggggc tgactgtaag tgattttctg aggcaggggg 68280atgactgtgt gtgattttct
gaggcagtgg gatgacagtg agtgattttc tgacacaggg 68340ggatgactgt gagtgatttt
ctgaggcagg gggatgactg tgagtgattt tctgaggcag 68400agggatgaca gtgagtgatt
ttctgaggca gggggctgac tgtaagtgat tttctgaagc 68460agggggctca ctgtgagtga
ttttctgagg catggggatc atgtgagtga atgtatgagg 68520cacggggctg actgtaagtt
aatttctgag gcagggggct gactgtgagt gaatttctga 68580ggcaggggga tgactgtgag
tgaatttctg aggcaggggg atgactgcga gtgattttct 68640gaggcagggg gatgactgtg
ggtgaatata tgaggctggg ggttgactgc gagtgagttt 68700ctgaggctcc cctcccccca
ggccgctggc cgcctccatg accccctggg ggagcggctc 68760tgtgtctcct ccctgtcgcc
atggcgacgc aggcggccag gcagcccccg ggctggggaa 68820gggcttggtt cccgccctgc
cagcacaggc cggcctgcca tctcagtcat ccccctgcct 68880cagctctgcc cctgggatta
caggcctggg cgggtccctg cctggggccc tgaggctcat 68940gaaccccaga gctgaatccc
tgcatccaaa caaagccaaa cacccccaaa ctcgtaactg 69000tgtgaggctg ggggatgacc
atgagtgagt gtgtgtgaat aaaataataa aataaataaa 69060atgcaaacac agcgccaggg
caggcggccc agtgtgtgtg tcacaactgt gtgactgtgt 69120gaggcagggg gatcactgtg
agtgattttc tgaggcaggg ggatgattgt gattcatttt 69180atgagacagg gagatgattc
cctgtgactg ttgaggcagg ggcattactg tgaataaatt 69240tctaaggcag aggcataact
gtgagtgatt ttctgaggca gtgggatgac tgtgagtgat 69300tttctgaggc agggggatga
ctgttagtgt gtttttgacg taggggtttg atgctgagtg 69360actgtgtgac acaggagatt
gaccctgaga ggctgtgtga ggcaggggga tgttagtgag 69420tttctctgtg aggcaggggg
atgatgctga gtgagtgtgt aagtcagggg gatgactgtg 69480agtgattttc tcggccacag
ggatgactgt gtttgagtct ctgagacagg gggctgactg 69540taagtgattt tctgaggcag
gggaagagtg tgtttgattt tctgaggcag ggggatggta 69600gtgagtttcc gtgtgaggca
gggggatgac tgtgagtgat tttctgaggc agggggatga 69660ctgtgagtga ttttctgagg
cagggggatc actgtgagtg attttctgag gcagggggat 69720gactgtgatt cattttatga
gacagggaga tgactccctg tgactgttga ggcaggggca 69780ttactgtgaa tgaatttcta
aggcagaggg atgactgtga gtgattttct gagccagggg 69840gatgttagtg agtttctgtg
tgaggcaggg ggatgactgt gagtgatttt ctgaggccgg 69900ggcatgactg tgagtgattt
tctgaggccg ggcatgactg tgagtgattt tctgaatcat 69960ggagatgaca gtgagtgatt
ttctgaggca gggggatgac tgtgagtgat tttctgaggc 70020agggggatgt ctgtgtgtga
ttttctgagg cagagggatg acagtgagtg attttctgag 70080gcagagggct gactgtgagt
gaatttctga agcagggggc tcactgtgag tgattttctg 70140gggcgggggg atgactgtga
gtgaatgtat gaggcagggg ctgactgtaa gtgattttct 70200gaggatgggg gatgactgtg
agtgattttc tgaggcaggg ggatgacagt gagtgatttt 70260ctgacacagg gggatgaagc
agagtaactg tggggcaggg ggatgtggct gtgtgactgt 70320ggtatgcagg gggatgactg
tgagtgattt tctgaggatg ggggatgaca gtgagtgatt 70380ttctgaggca gagggatgac
agtgagtgat tttctgacac agggggatga ctgtgagtga 70440ttttctgagg cagggggatg
actgtgagtg attttctgag gcagagggat gacagtgagt 70500gattttctga ggcaggaggc
tgactgtaag tgattttctg aagcaggggg ctcactgtga 70560gtgattttct gaggcggggg
ggatcactgt gagtgaatgt atgaggcagg gggatgactg 70620taagtgattt tctgaagcag
ggggctgact gtgagtgaat ttctgaagcg gggggatcac 70680tgtgggtgaa tgtatgaggc
tgggggatga ctgctagtga atgtctgagg ctcccctccc 70740cccaggccgc tggacgcctc
catgaccccc tggcgggagc ggctctgtgt ctcctccctg 70800tcgccacggc agggatatga
ccgcgattaa ctgtgaggca ggggaatgaa gcgaagtgac 70860tgaggcaggg ggatgactgt
gattgaattt ctgaggcagg gggatgactg tgagtcagtt 70920tctgaggcag ggggatgact
ctgagtgagt gtgtgaggca gttggatggc actgattgtg 70980ggtgtgaggc agggtgatga
gtgtcagtga atttctgagg cagggggatg actgttagtg 71040agtttctgag gcaggggtga
cctggtttga atgtgtgagg cagggggtga tgctgagtga 71100ctgtgtgaca caggagattg
accctgagag gctgtgtgag gcagggggat gactgtgagt 71160gaatttctga gacaggggga
tgacagtgag tgattttctg aggcaggggg atgactgtga 71220gtgactgtgt gaggcaggtg
gatggcactg attgtgtgtg tgaggcaagg gtatgactat 71280gattgaattt ttgaggcagg
gggatgactt tgagtgactg tgtgaggcag ggggatgact 71340gtgagtgatt ttctgaggca
gggggatgat tgtgggtgat tttctgaggc agggggctga 71400ctgtgagtga atttctgagg
cggggggatc actgtgggtg aatgtatgag gctgggggtt 71460gactgcgagt gaatatctgg
ggcaggggga tgacctggat tgaatgtgtg aggcaggggt 71520aggaagctga gtgactgtgt
gatgtagggc tatgacgctg agtgactgtg aggcaggggg 71580atgaccctga gtgagtgtgt
gaggcaggtg gatggcactg attgtgggtg tgaggcaggg 71640ggatgactgt gagtgaattt
ctgaggcagg gggatgactg tgagtgaatt tctgaggcag 71700ggggatgact gtgagtgaat
ttctgaggca ggggaatgac gctaagtgac tgtctgaggc 71760agggggatga ctgtgagtgg
ctgctgtggg ggagggtcag gtccgcacac ccgccgcagc 71820agagcctgct gggagctcag
cctctgcaca cacggacgga cggacagaca gacagacaca 71880caggcagcca ggccttccag
gtctgcttgc cagggctcag agcccagtgt caatcacact 71940cggggccccg cccacccgga
atcccccagg cagctgggcc aactgccacc ctgtgggagt 72000gggggagagg tcaggcaggg
agctgggccg tcgccatgga gacgacggcc tgggagcccc 72060gccccgcctg cctgtcagtc
accgaggctc cctggctccg cccacccgga atccccaggc 72120agctgggcca actgccaccc
tgtgggagtg ggggagaggt caggcaggga gctgggccgt 72180cgccatggag acgaaggcct
gggagccccg ccccgcctgc ctgtcagtca ccgaggctcc 72240ctggctccgc ccacccggaa
tcccccaggc cgctgggcca actgccaccc tgtgggagtg 72300ggggagaggt caggcaggga
gctgggccgt cgccatggag acgagggcct gggagccccg 72360ccccgcctgc ctgtcagtca
ccgaggctcc gggccccgcc ccctgtcagc tcagggattc 72420cgcaggccag gcctgtgccc
gcgtggccgg ctgtggatcc gtggtgctcc tgtgtgggcc 72480gtgggctcca cgtcctggcc
ccggtgggcg tgggggacac acggggtctc tgtgtctgtg 72540cggccaggcc cggccgtgcc
gggaactcac tgcgctacct agggctggcc gggaactcca 72600atcatccccc tgtctcagct
ctgaacgtga acgtgaacgc ctgtctgagg cagggggatg 72660gcgccgagtg agcagtagag
gcgaggcgcg gcctcgtgcg ggtttaggtc agcgcgcggg 72720ggacagagtg aaggagccca
cggcgcctcg tagccggagg tcgaggcggg cggcgaagcg 72780gccgaggaca gggcggctgc
agcgggcggc ggagccaagt agccgggcag tgaacgtgtg 72840aggcaggggg atgaccgcga
gtgactgtat gaggcagggg gatgaccgcg agtgactctg 72900tgaggcaggg gcatgaccgt
gagtgatgct aagtgactgt ctgaggcagg gggatgactg 72960tgagtggctg ctgtgggcga
gggtcaggtc cgcacacccg ccgcagcaga gcctgctggg 73020agctcagcct ccgcacacag
ggacggacag acagacagac acacacagac ccgccacagc 73080ctgggcacgc agccgcggga
tttcccgcct gagacgaatc aatgaaatga agagcgcggg 73140cggccccgat ctgatgacgt
cacgcgtttc ctggtcgttc acgctgtgtg cggcagaggg 73200cggaggcagg gggatgactc
ccgcgagggg gaggctgaac cccgagtctc tcggcgcctg 73260ggctgccgcg gctcacgccg
ccgccggggt ctgacagggc tcgcgagagg cgggtcctgt 73320tcagagcgag ctccgcgcgg
cggctcgtct cggggtctgt gggcgggacc cgctgtcacc 73380ccagccgacg gcctcggcct
cggggtcgct atgagtgact gctgtgggtg aggcaggggg 73440atgaccccga gtgactaact
gtgaggcagg gggatgacgc tgagtgactg tctgaggcag 73500ggggatgaca tgagtgactg
ctgcgggtga ggcaggggga tgaccccgag tgactgtgag 73560gcagggggat gacgctgagt
gactgtctga ggcaggggga tgacatgagt gactgctgcg 73620ggtgaggcag ggggatgacc
ccgagtaact gtgaggcagg gggatgacgc tgagtgactg 73680tctgaggcag ggggatgaca
tgagtgactg ctgcgggtga ggcaggggga tgagcccgag 73740taactgtgag gcagggggat
gacgctgagt gactgtttga ggcaggggga tgacatgagt 73800gactgctgcg ggtgaggcag
ggggatgacc ccgagtaact gtgaggcagg gggatgacgc 73860tgagtgactg tctgaggcag
ggggatgaca tgagtgactg tctgaggcag ggggatgaca 73920tgagtgactg tctgaggcag
ggggatgaca tgagtgactg ctgcgggtga ggcaggggga 73980tgaccccgag tgactgtgag
gcagggggat gacgctgagt gactgaggca gggggatgac 74040atgagtgact gctgcgggtg
aggcaggggg atgaccccga gtaactgtga ggcaggggga 74100tgacgctgag tgactgtctg
aggcaggggg atgaccccga gtaactgtga ggcaggggga 74160tgacgctgag tgagtgtctg
aggcaggggg atgacatgag tgactgctgc gggtgaggca 74220cggataggac cgcgactaac
tgtgaggcag gggaatgatg ctgagtgact gtctgaggca 74280gggggatgac atgagtgact
gctgtgggtg aggcacgggt agcacagcga gtaactgtga 74340ggcaggggga tgacgctgag
tgactgtctg aggcaggtgg atgactgtga gtgattttct 74400gatgcagggg atgactgtga
gtgattttct gaggcagggg gatcgctgtg agtgatttgt 74460gctgattgaa tgtgtgaggc
aggggcatga aaatgaggca ggagatgaag ctgagtgaat 74520gtatgaagca gggatttaac
tgtgagtgag tttctgaggc agggggatga ctgtgagtgt 74580gtttctgaca tagggggatg
atcctgagtg actgtgtgac acaggagatg gaccctgaga 74640ggctgtatga ggcaggggga
taacagtgag tgattttctg aagcaggggt ttaactgtga 74700gtgtgtttct aaggcaggag
gataactgtg agtgattttc tgaggcagag gaatgactgt 74760gagtcatttt ctaaggcagg
ggatgactgt aagtgatttt ctgaggcagg gggatggttg 74820tgagtgattt tctgaggcag
tgagatggct gtgagtgatt ttctgaggca gggggatggt 74880agagagtttc tgtgtgaagc
agggggatga ctgtgagtga ttttctaagg caggggatga 74940ctgtaagtga tttgtgctga
ttgaatgtgt gaggcagggg catgaaaatg aggcaggaga 75000tgaagctgag tgaatgtatg
aagcagggat ttaactgtga gtgagtttct gaggcagggg 75060gatgactgtt agtgtgtttc
tgaggtaggg ctttgatcct gattgactgt gtgacacagg 75120agatggaccc tgagaggctg
tatgaggcag ggggataaca gtgagtgatt ttctgaagca 75180ggggtttaac tgtgagtgag
tttctaaggc aggaggatga ctgtgagtga ttttctgagg 75240cagaggaatg actgtgagtc
attttctaag gcagggggat ggctgtgagt gactgtgtga 75300gtcgggggga tgatgctgag
tgagtgtgtg aggcggggga atgatgctga gtgattttct 75360gaggcagggg ggtgactgta
agtgattttt tgaagcaggg agatgactgt gagtgatttt 75420ctgaggcagg ggcatgactg
tgagggattt tctgaggcag ggggatgaca gagagtgatt 75480ttctgaggca gggggatgac
tgtgagtgat tttctgaggc agggggatga cagtgagtga 75540ttgtctgagg cagagggatg
acagtgagtg attttctgac acagggggat gactgtgagt 75600gattttctga ggcaggggga
tgactgtgag tgattttctg aggcagaggg atgacagtga 75660gtgattttct gaggcagggg
gctgactgta agtgattttc tgaagcaggg ggctcactgt 75720gagtgatttt ctgaggcaat
ggggatcact gtgagtgaat gtatgaggca ggggctgact 75780gtaagtgatt ttctgaggca
gggggatgac tgtgtgtgat tttctgaggc agagggatga 75840cagtgagtga ttttctgaca
cagggggatg actgtgtgtg attttctgag gcagagggat 75900gacagtgagt gattttctga
cacaggggga tgactgtgag tgattttctg aggcaggggg 75960ctgactgtga gtgaatttct
gaggcagggg gatgactgtg agtgaatttc tgaggcaggg 76020ggatgactgc gagtgatttt
ctgaggcagg gggatgactg tgggtgaata tatgaggctg 76080ggggttgact gcgagtgagt
ttctgaggct cccctccccc caggccgctg gccgcctcca 76140tgaccccctg gcgggagcgg
ctctgtgtct cctccctgtc gccatggcga cgcaggcggc 76200caggcagccc ccgggctggg
gaagggcttg gttcccgccc tgccagcaca ggccggcctg 76260ccatctcagt catccccctg
cctcagctct gcccctggga ttacaggcct gggcgggtcc 76320ctgcctgggg ccctgaggct
catgaacccc agagctgaat ccctgcatcc aaacaaagcc 76380aaacaccccc caaactcgta
actgtgtgag gcggggggat gaccatgagt gagtgtgtgt 76440gaataaaata ataaaataaa
taaaatgcaa acacagcgcc agggcaggcg gcccagtgtg 76500tgtgtcacag ctgtgtgact
gtgtgaggca gggggatgtc tgtgagtgat tttctgaggc 76560aggggcatga ctgtgagtga
ttttatgtga gtgactgtta gtgtttgacg taggggtttg 76620atgctgagtg actgtgtgac
acaggagatt gaccctgaga ggctgtgtga ggcaggggga 76680tgttagtgag tttctctgtg
aggcaggggg atgactgtga gtgattttct gaggcagggg 76740gatgacagtg agtgattttc
tgaggcaggg ggatgactgt gagtgactgt gtgaggcagg 76800gggatgacac tgattgtgtg
tgtgaggcaa ggggatgact gtcagtgatt ttctgaggca 76860gggggatgac tttgagtgac
tgtgtgaggc agggggatga ctgtgagtga ttttctgagg 76920caggggaatg acaaggagtg
attttctgag gcagggtgat cgctgtgagt gattttctga 76980ggcagggggt tgactgtgag
tgagtttctg aggcagggca gggcatcgtg gtgcccggac 77040atcattaatc cctgcactct
ggagtcagag gcagggggat gactgtgagt gtgtttctga 77100ggttgagtga gggtgtgagg
caggggcatg acgctgtgtg aggcaggggg ttgcctgtaa 77160gtttctgagg cagggcaggg
catcttggta cccggacgtc attaatccca gcactcggga 77220gtcagaggca gggggatggc
tgagttggag gccagcctgg tctacagcct gagctccagg 77280acagccaggg ctacacagag
aaaccctgtc tcgaaaaacc aaaaaacttt ctgaggcagg 77340gggatgactg tgagtgtgtt
tctgaggcag ggggatgact gtgagtgatt ttctgacaca 77400ggggaatggc agtgagtgat
tttctgacac agggggatga ctgtgagtgt gtttctgagg 77460caggggcatg actgtgagtg
attttctgag gcagggtgat gactgtgagt gattttatga 77520tgctggggga tgagtatgag
tgattttctg aggcaggggg ctgactgtga gtgattttct 77580gaggcggggg gatcactgtg
agtgaatttc tgaggcgggg ggatcactgt gagtgaattt 77640ctgaggcggg gggatcactg
tgggtgaatg tctgaggctc ccctcccccc aggccgctgg 77700atgcctgtgg gtgtcacagc
tgtgtgactg tgtgaggcag ggggatgact gtgagtgatt 77760ttctgaggca gggggatgcc
tgtgtgtgat tttctgaggc aggggcatgg tagagagttt 77820ctgtgtgaag cagggggatg
actgtgagtg attttctaag tcagggggat gactgtgagt 77880gattttctga cgcaggggaa
tgactgtgag tgattttctg acacagggag atgaagctga 77940gtaactgtgg ggcaggggga
tgttgatgtg tgactgtgag gcagggggat gactgtgagt 78000gattttctga ggcaggggga
tgaatgtgag tgattttctg aggcagtgga atgactgtga 78060gtgagtttct gaggcggggg
gatcactgtg ggtgaatgta taaggctggg gcatgactgc 78120gagtgaacgt ctgaggctcc
cctcccccca ggccgctgga cgcctccatg accccctggc 78180gggagcggct ctgtgtctcc
tccctgtcgc catggcaggg atatgaccgc gattaactgt 78240gaggcagggg aatgaagtga
agtgactgag gcagggggat gactgtgatt gaatttctga 78300ggcaggggga tgacagtgag
tgattttctg aggcaggggg atgactgtga gtgactgtgt 78360gaggcaggtg gatggcactg
attgtgtgtg tgaggccagg ctatgactat gattgaattt 78420ttgaggcagg gggatgactt
tgagtgactg tgtgaggcag ggggatgact gtgagtgatt 78480ttctgaggca ggggggtgac
tgtgggtgat tttctgaggc agggggctga ctgtgagtga 78540atttctgagg cggggggatc
actgtgggtg aatgtatgag gctgggggtt gactgcgagt 78600gaatatctgg ggcaggggga
tgacctggat tgaatgtgtg aggcaggggt aggacgctga 78660gtgactgtgt gatgtagggc
tatgacgctg agtgactgtg aggcaggggg atgattctaa 78720ttaatagtat taggcagggg
gtgatgctga gtgactgtgt gaggcagggg gatgaccgcg 78780attaactgtg aggcagggga
atgacgctaa gtgactgtct gaggcagggg gatgactgtg 78840agtggctgct gtgggggagg
gtcaggtccg cacacccgcc gcagcagagc ctgctgggag 78900ctcagcctcc gcacacacgg
acggacggac agacagacag acacacaggc agccaggcct 78960tccaggtctg cgtgccaggg
ctcagagccc agtgtcaatc acactcgggg ccccgcccac 79020ccggaatccc ccaggcagct
gggccaactg ccaccctgtg ggagtggggg agaggtcagg 79080cagggagctg ggccgtcgcc
atggagacga gggcctggga gccccgcccc gcctgcctgt 79140cagtcaccga ggctccctgg
ctccgcccac ccggaatccc ccaggcagcc gggccaactg 79200ccaccctgtg ggagtggggg
agaggtcagg ggatgacgct gagtgactgt gggaggcagc 79260gcatgactgt gagtgatttt
ctgaggcagg gagatgactg tgtctgagtc tctgaggcag 79320ggggatgatg ctgattgaat
gtgtgaggca ggggcctgaa aatgaggcag gggattaagc 79380tgagtgaatg taggatgcag
gggtttaagt gtgagtgcgt ttctgaggca gggggatgac 79440tgtgagtgac tgtgggaggc
agcgcatgac tgtgattgat tttctgaggc agggagatga 79500ctgtgtctga gtctctgagg
cagggggatg atgctgattg aatgtgtgag gcaggggcct 79560gaaaatgagg caggggatga
agctgagtga atgtcggaat gacagcataa gaaaaatata 79620aaaatatttc cacgtcgctg
cttctccttt attctccccc cccacccccc ccccccgcgc 79680acaccaccga catcggaccc
ggatgacaaa acgaatcccc accctcccga ccccgacccc 79740taaccccagc ccaacgatgt
gataaaaaca gaaacgatgg ctgacatggg atgtttggcc 79800cggggttcac ccacacgcaa
acagcaggcg agtgacataa aaaaataatc atgttgggga 79860aaaacccatg tgtttgtttt
cccttgtggt ggtgacatcc aacctgggcg ggtgaccccc 79920aagcaccggc ccgacccagg
ggggtcaggc cacagaagaa caagtgcaac gtgtgaaaaa 79980actgtgccta cggttcacac
atacgcaaac agcgacgagc agtcaatgac agtctaagaa 80040aactataaaa aagaatttcc
gtgtcgccgg tcacgaccgc cgcattctcc tctgtcacca 80100ccgggtggcg acagagagca
cgccgggaaa aacctccgct ccgggagtcc tcccaggggt 80160cggagtctgc gaggggaaag
cgacgaggag gggacagacg cccgagatcg actccagatg 80220aggccagatg tcttccgggg
tggcagaatc gagaacgtga cgagaagcgc tgttttccaa 80280acgtttctct tgctggcgtc
gtcgtcgtcg agacgttctc acaaattttc agaggaaaat 80340gaaacatttt ccaccgaggt
gtccgtgttt aagatgtgaa gtcgttttaa gtcgctatca 80400aaatattcat ctgggtatca
atgatacagt cacagctgaa atgtctccac tcacatcgga 80460gtgaggaagc ccgcgggctt
ccttattagg ctcaagacgg cttctgcttt agccgtctat 80520ccggttcttc taagcggtcg
tgcccagcct ggcctcagta tggaatagaa ttttctgaag 80580cagggggatg accctgagtg
accgtgtgag acagggggat gactgtgagt gattttctga 80640ggcaggggga tgaccctgag
tgaccgtgtg aggcaggggg atgactgtga gtgattttct 80700gaggcagggg gatgactgtg
agtgattttc tgaggcgggg ggatgactgt gaatgatttt 80760ctgaggcagg gggatgaccc
tgagtgaccg tgtgaggcag ggggatgacc ctgagtgacc 80820gtgtgagaca gggggatgac
tgtgagtgat tttctgaggc agggggtgac tgtgagtgat 80880tttatgatgc tgggggatga
gtatgagtga ttttctgagg cagtgggatg actgtgagtg 80940attttctgag gcagaaggat
gactgtgagt gattttctga agcgggggtg atcactgtga 81000atgattttct gaggcagggg
gatgattgtg agtgattttc tgaggcaggg ggatgaccct 81060gagtgaccgt gtgaggcagg
gggatgactg tgagtgattt tctggacaga ttggggaaga 81120tgtcacgacg ctctggaagc
ctgagtttct cgaccccata aacagcggcc tccacctgtg 81180tccctccccg gggccgctgt
ggggccgggt ccctcaaggt cgctgctccg tacagtccag 81240atggtccggg atgggcagac
ccgtgacgat ggtcagacac ttgttccaca cggtgaaggt 81300ggggcacacg ggctgcgcga
gcgccgcgtg gaaggtgtgg aggtggacgg agctcagagc 81360gtcgtagaag gcgatggagc
cgttgtcgta gtccagcagg acgccgacgc gcctgaggtg 81420aggggccggc gcgatggggg
tctccttgcc gtcgtgtcgc accgcccagt ggttgtggca 81480gcggcagagg gcccaggacg
ccgcgttctt cccgatccac tcgtgtttcg gcgccgatct 81540gtacgccagg ccgatggcgt
acctgccgag aaaaaaaaga aaatcacatc gcctgtcggt 81600gagatttgct cgtggtccac
aggtgttttc tttttaaagt gatcctttat tggcgatcac 81660actcccttta agtctttacg
tctaaatatg tctgtctgtc cttcctaaac acattagagg 81720tggacggcgg ccggtgtgtc
gaccgacctt ctggtctgca gcttaagtgt caccagagaa 81780tctcgatttt ccattccttc
actgccccgt ttctctcctg tgcatgcccg tgcagacggg 81840tggacagaca gacagacaga
gggacggaca gatagacaaa agatggacag acagatggac 81900agaagagcag acagactgat
ggacagaaac agacagagag aagggcagac aggtagacgg 81960atgggcagac agacagacag
agggacggac agatagacaa aagatggaca gacagatgga 82020cagaagagca gacagactga
tggccagaaa cagacagaga gaagggcaga caggtagacg 82080gatggacaga cagacagaca
gagggacgga cagatagaca aaagatggac agacagatgg 82140acagaagagc agacagaccg
atggacagaa acagacagag agaagggcag acaggtagac 82200ggatggacag acagacagac
agagggacgg acagatagac aaaagatgga cagacagatg 82260gacagaagag cagacagact
gatggacaga aacagacaga gagaagggca gacaggtaga 82320cggatggaca gacagaggac
aggtggacag atggacagaa gacagatgga cacacaggga 82380cagacaggtg gatccagacg
gagacggcct accatgtgct tccgctggtg accacttccc 82440agtagtgacg gccgctgtcg
atgaacacgt tgccagccac tccgtagctc ccctgaccag 82500cgaagcgctc cggcgcgtga
ctcttcttag aggacgactc gtcgcgctcg acagtcaggt 82560tgtcgtggga caccttcagc
ttgcgatgag ccgatttggg atccagtcta aacggctgac 82620ctgaaggcga gttcaccaga
gagagagaca ccaagagcac ggttgactgg aaagatgaca 82680ggtagcgtga cctcatttac
atttaagagt ctgaaacaag ggctcaaggg agagagctgc 82740ctaaatgcca acagcaacgc
ctaggttttc tatatttgga tttattaata cacataataa 82800gcagagttga catattctgg
gttcacacat atgcaaagag tggtgagcca tcaacgataa 82860taaaagaaaa acgaacgtgc
acgtagatgc tttgaaaaag aatcaacgct cacggaaacc 82920aaaaacaagt gtcctttgaa
aaaaagaaaa tcggacggtc acgaccaccg cattctcctc 82980tgtcaccacc gggtggcgac
agagagcacg cagggaaaaa acttcctcca aggggtcgga 83040tctgcctgct tcatcccggc
cagggtgagg ggaagccggc caggctggcg gatccgaccc 83100ggcgaggcgg tcgcgttttc
catcggtcgg tccccgggag gttgtactct gtgagataca 83160ggaagtgcct ccattttgga
caggaagtcg ggcccaggcg ctcatgggag ctgtagtgcg 83220tctaggctag ggcccagcgc
cgatctccgg ggccacccgg tggcgagaaa cgcgcaagtg 83280cacccccggt tctctgcctc
gcggggacgg atctgggacc cgaaggcccc aattgagaac 83340ctcgatgcgg ctgctgggaa
cctcagtgtt tcacatcggt ccttgattca cttgtgtgag 83400gctgtcagtg aggcccagga
cggaaaacgt aaaagaaagg tggggagcag cctcagcccc 83460aaaggcaagc agccgtgaga
tggcagctca gccgagttca cagcactcac tgttggtctt 83520cagctttccg ggctcactgc
tactgaagca gggggatgac cctgagtgac cgtgtgaggc 83580agggggatga ctatgagtga
ttttctgagg cagggggatg accctgagtg accatgtgag 83640gcagggggat gactgtgagt
gattttctga ggcaggggga tgaccctgag tgaccatgtg 83700agacatgggg atgactgtga
gtgattttct gaagcagggg gatgaccctg agtgaccatg 83760tgagacaggg ggatgactgt
gagtgatttt ctgaagcagg gggatgaccc tgagtgacca 83820tgtgagacag ggggatgagt
gtaagtgatt ttctgaggca gggggatgac tgtgagtgat 83880tttctgaggc agggggatga
ccctgagtga ccatgtgaga cagggggatg actgtgagtg 83940attttctgag gcagggggat
gaccctgagt gaccatgtga gacaggggga tgactgtgag 84000tgattttctg aggcaggggg
atgactgtga gtgattttct gaggcagtgt aagctggcag 84060ctcagccgag tccacagcac
tcactgttgg tcttcagctt tccgggctca ctgctacggc 84120tgcccgcctg gttgatggcc
ttcaccgtga agatatactt ggtgccactt tgcaggccgt 84180gcacggtgta gtggttctgc
ttgatgttgg gcacgatcat ccagctgtcc gccgagttac 84240acagacctgc ggagccgagg
agacaggtgc cgtcacaggc cacgtctgca gaatggcaga 84300ttatttggac attgaacatt
ggaaaacgga gagctttctg gctctttatg tggcttgatc 84360aataaaacac tgctcagcgt
gctacctcta tggagagttc acttcgtacc atatacgttc 84420tctttgcgcg ttccgctttt
ctgccacact tttctctatt ccgtacaaac aatcctaatt 84480aatatctaca attttaacct
ctgataatac attttacgta agagtggttg agtttggata 84540tctatgttat gaggtgatca
atggattcac agtgtgtatg tggttaccgg cttctttttt 84600aaaactacat ccgggctggt
gagatggctc agtgggtaag agcacccgac tgctcttccg 84660aaggtccaga gttcaaatcc
cagcaaccac atggtggctc acaaccatcc gtaacaagat 84720ctgactccct cttctggagt
gtctgaagac agctacagtg tacttacata taataaataa 84780ataaatcttt aaaaaaaaaa
actacatcca tgtggttttc cggaggttgt taatttcatg 84840ggtatttagt cagctgttct
catgactgcg atacaagtga gcattatcca ttccttgaac 84900aggaaagaga agccgataaa
tattgtcatc atgttcagtc ctcatcatct cctttctgtg 84960ttgagatccc ttcacccagc
tcatctgaaa acagtcgtcg aacgcggaag ggaatcagcc 85020gagagatact cactgacaac
attggcttgt ccggtgaata tggtgtactg gagctcgtag 85080gagaccacgc tgaactcgtc
ctctgaggtc cagtggacgg tgatggtgtc ataggaagcg 85140gtgcagagct cttctctaat
cgtgggagcg ttgggagctg tggacatcac acgcatgtca 85200gcggagcagc agataccatt
aggacgacaa tttggaggta ttcgactgtt gaagcaggtc 85260ttcctcctaa acaggtctag
cacatttact aacaggaggt tttggttcca gagcgctcag 85320ccgtctactt aaagaatgtt
tcagggttta tctgttgttg atttttctaa gcggtgtgac 85380taaagccagc cagccggccg
ctaagacgtc acctcgattt atcatgagaa tatatttatg 85440agagtaagag aacaatagct
tcttgtgtat gaagaaagat agatcagaga aaaagtaacc 85500atggcagact ttcataatgt
cattctcatt tggtaggggg tggggggtgg aaatcttact 85560aatcaaggac tataggatcg
acattttagg tattgtagga cagacttctg ctctcgcacc 85620tacttaaccc tgccattaga
gcggatgtag atgatttgta cgtaaagagt acgaccagac 85680tctcataaaa tcttatttac
aaaacagcca cagggcctga tttggcttga aacccactat 85740gccaatctct cgtccacacg
ccaccagcta ttttaaaaaa tatcacggtg atctgctaag 85800aaatcaacaa gtcatttaaa
ttcttccttt atctttattt tcttgtccct gtttctactt 85860ggtctgtgtt atttaggtta
gaatacagcg cggacattca tctttatagg actatcagat 85920agcatttcag agactgaagc
acgtgtatgg gttttagaag ataatcgact caatggtaaa 85980gtgaatagac actgtactag
agagaacata gaagagagta agacgatacc tgttaggtaa 86040tccagacact ctagcagttt
cttctcccgg gaaaaatcca aggcaaaagt gtcaaacgtg 86100tcattgaggt tgatttcggg
aattaggacc tgggaggatg cagttgccat ggagactctg 86160tcatttaaac aagacactgt
tttaagaaat gtcaaggtgg cttttatcac cactgtgaag 86220gagtgagaac aaaaccaaag
gaaaagaaat atcagggttt taaaaagcac cccctctgaa 86280aaggcgtcac gtgcgaacgc
aaacaacctc acagagaaag cagaggaatt gggagaggta 86340acccggtgcc accccccccc
cttctttaaa atatccgaaa aagtccccac ggaagcagaa 86400gaatcttcat atttcgtgct
gctgtgtatt tgacagcccg gcccggtcac atcgaacccc 86460ggccagaagc gcacagcttc
aggcatctct tcacacatct gtctgggaaa ctgtctgttc 86520ctttcagact cgcccctgcc
ccacttccaa ggggagtctc cagaatttca aactgcatca 86580aaggcagagt gaagattaaa
aaagaatgtc tccagatctt ggattagttt aatcaattac 86640tagcccctct ctaaaataaa
catgaaaagg gggggagggg ttgtctggct ctttctcgtt 86700ctcccgctat tcgccttttt
tcccctaccg tcttcccaac agatgccacg ggaaatattc 86760ctgagctttc tcagaaattc
cccagtcggc acacaatctc gtccctacgc tcagattttc 86820tggtgagtgc tcccttgtat
aaagcgtaaa gcaaggtatg tgtgtctgtc tcctgtgtgc 86880tcttgagttc atttggaaag
tgactgacag cagaacaatc tagcgggtgc taaaatgcaa 86940gtaattatgt ttacacaaag
aaaaccatgt cttgaataat gctactactg agcatagaga 87000atgatctaga cttattttga
tgtgttttat ggttttgttg agttcaagct gaaggctgtc 87060acggaaaggg ttttatcatg
tcgaaggaaa gcgttcttag ctggagcaaa ccagccgaag 87120cttccattct ctctggcact
cgacctctaa cagaaaacaa gtcagtcgga gagcaaggcc 87180gaccggtcag tcccacgcag
atatgagcca ccatcagcct gacagcttcc cagctgtccc 87240tgcacccacc tctcagtgat
attctttgct gtctgtagaa aacgggcgtg gtcattttcc 87300ttcagcgagt gctccgcttg
cgagatgagc gatgcagacc tctcaaggca ctgtttacag 87360tttgcaatct gctgagctaa
cttgcggagc ctgatcacct ggaacgagag aagcacggcg 87420ggcgaggtca cacgttaagg
atcgatcgct tgggaggtgg ctcagggctg aacccttcag 87480aggcgtgagg tctgttctgt
ctaagcagag agaggttgaa atccggaagg caaatttttg 87540gaacttgaac tttcagtctt
tggagaagcc ttagtcacct gtttgatgag gagacactaa 87600ttcgtgtcag tgtgacacta
actcacacta gcatcgctca ttacttctct gttgaagggg 87660ggaaaggtgt ccgctggcaa
gtgacaaacg gtcaccgaat ctcttccttc tgccatccta 87720cctaatgact tcaggacctt
agagaaccct ggaactctct ccatctcagg ttttcaatat 87780gcctttaaga aaataaaaca
tgtctgtagg tgtgaattcg aggcttaagt taaaaacagt 87840gaaaaaaaac cctacaaagt
tctttgtaat ccacgtaata aagttgtgac atgaaagcat 87900taggtattcc tattttccat
actgcctaaa acctgtgtat gaaattaaca gagagggagc 87960attttcccat tgattgatat
ttttcttatt ggactgatga gagaaagcca aaaaaagcac 88020agctgggcca tttcctctca
ctgtaaacgt catttccagt cactttgtgc agcatggtaa 88080aaacacatcg ttcattgtaa
aggtaggtct tgtccctatc aggagaagtg tgtacccgag 88140tcgaacaaaa taacaccatt
tcacaccaga tagaacagag cctctggcaa cattatctag 88200agagtcgagg cagccctcta
gcctaactca gggtgttaga acacatctat taggaactgt 88260cagaggaagg gagaattcca
gaaggataag ttaatagtct caaccataaa ccagatgagt 88320ggaatattta attatataac
ataaagaaga tttaaatggt acggccaagt tgaaggcaga 88380tgataaaatt ctcaccaaac
gagatgaggt cagactactc ttctggcttc atttcatgtc 88440actctcttag cctttgaata
ggcacagcag agaccacacg tctcaaaaat gacggctctt 88500caatgtcata tttttcaggt
ttttcctctg aggctatgtg gagattaacg gtgatgttta 88560aggacaagaa gaataaccga
aacaggagat attgatgtaa aagaaattga gagcatactg 88620tgaaactgcc acgatcttct
cgagtggact tccatgtaga gcgtactttt cattacaggt 88680cagttgacag ttgcctcgga
gattcacaaa cactgtgtgc gatagaatca gctggggatc 88740tttcccagga aaactctaga
tgtctgggca catcctctgg cattctagtt aaggagctgc 88800cattggcaga gccacagtaa
tttgcatttg aacgagcaac gcatgttttt aagtctccgg 88860gtgatgaatg actagtatgg
tcgggaccag catttcaaat atcaatctcg ctttaatctt 88920tgagtccatg gacatctgtc
atgcttgaat gtcactcaga cccttttgtc ccttcttacc 88980tcgatggaac tccccaggca
gaggccaaaa ctcagtcccc acggaagcag aagaatattc 89040atatttcgtg ttgctgtgta
tttaacagcc tggcccggtc acatcgaacc ccagcaagaa 89100gcgcatcaat gataataaaa
gataataaaa aagaaaaacg aacgtgcacg cagatgcttt 89160ccaaaagaat caacgctcac
ggaaaccaaa aacaagtgtc ctttgaaaaa aaggaaaatc 89220gaacggtcac gaccaccgca
ttctcctctg tcaccaccgg gtggcgacag agagcacgcc 89280gggaaaaaaa aacttcctcc
gaggggtcgg attgcccaat ttcttctgta gctgttttct 89340gtcacataat tgtctacgag
tttacctcca aaacttattg attgcattcc cgtctgtgtg 89400tttcttcttt gagtcctttt
ttgtctgtga tttctttatc tctaaactgt ttcttttcag 89460gtctgcgtcc tcttctgcaa
aacgaatctt accggaaatt agataatgct gctgattttg 89520ctggctgtgc ttttagaaac
tcaagatttc ttggcttgct tcggaaatga gctcagcacc 89580tcagttttaa agaaaagaat
ctgaaaatag cttcttgttc tccttggtgt gctctaatgg 89640ttttactttt ctgctttccc
ctaaccaggc tcctgggctc agcgctctgc aatccaatct 89700cactgtggac tcctgtctca
tctctgtgtc tctgaggcac ctgtctggtg tgataataga 89760atgagtggag tacgggtcct
cttaacgact gacttgttcc agaacctcag aactgaagtc 89820tgccaaaagc tatgatgcca
ggcagacatc ggcaatactc tcttcccgtc cctcgtaatg 89880aataagaagc cttctgcagt
ctgtggcgct gaggcacagg cctggtttct gccttccatc 89940cgatccaaag caattccaga
ttcttccagg atgtttttta ggcacaggca tcggaactgc 90000aggcatgccc gtatctcttc
aaccatgcct gtgcttccag ccacagttgt ggcattgcac 90060tttcatgcca ttcctgcttc
accgaaatgc tgctctcatt tcactcttca ccgttggagt 90120ccatgtctat taatggtgta
tgtctgcagc ggagtgagtg ctacaaaaga tggactctac 90180ctataatcat ggcccaaact
ggaatacctt ttattactat cctctagctc ctgaaaggaa 90240accccaggcc gtgaaattca
agctgcagct gagtaagggt aagtaagtac ggttgctgca 90300gaggtatgaa aaagtgccac
tgcaatctga agatggactc ttagcgaagt ccacatcggc 90360accttgggaa tctttcagta
tgctaccttc cataccaaag gaactttgta gatgtctagg 90420ttaagaatct taaggggttg
gggtggtcca ggatcgtctg ggtaatctct acataattcc 90480taaggtcttt atgacagaga
gacaggacgg ttcatgtcag tgaagtagat agcaggatga 90540agacagaagg cagagtgcta
atgacttagt tgtgagccaa ggaccatgga tgacctccag 90600aaacttgaca agacaagcat
agcttactaa cattgccttt aacctatgta gcctttagta 90660cagtgagact gctctcagac
atcagaacag taagataatc aataagaagg ttctaagcta 90720cacagttttg gtaatgtgta
atagtacgat agaaaccatc ataagaagaa tacagaacca 90780attaaacagg agaacagagg
ctttttaaaa aaattttttg agctacattg catagattaa 90840caaatatacc aaatgtaaat
ttcttacact tccagattac tagaccgtta aattcgagaa 90900tttatcacca caaaaataag
tgtttgaggt gatgaatatg ttacttagct tgatttaatt 90960attatacatt ctattcatga
accacagaat catgtcgtat ccaccaacat gtacacgtgt 91020aacttgtcaa tttaacatta
aaacgataaa ttttctaaag aaatttatgt gggcatgtag 91080agtattgatc ctggcatgca
accacttgac aatagcagat tatcttcttg gaacataata 91140gcaactaacc atggcagaaa
aacaggcatc tgagaaacta ggagacgaaa ggaatgagag 91200atgagtccac atgatgaaag
aagatgcact atgcggaagt atattctcag tagattctag 91260gtggacactt actgccagag
gcattgagca aacatggtgc catgctattg ggaattttaa 91320gaaatatgaa taattctctt
tcggttcttc actactcttt gtcgagtatt ttactacagc 91380aacacaaaat ggaccaaggc
aggtagttaa gaagggatta tgacgaatgc agagagtacg 91440atttgttttt aactttcaaa
gctgtagatg ttggagagaa agtatatatt cttcaggtga 91500gaaatacaga acctttttat
caaggaaacc ataccttgcc ttctttaatc tttgttccaa 91560taatttgtct tcgttgctga
atgatttcaa tgagaagatc acattcttct gtcagtttgg 91620cttcttgacg ggatgcattg
acctacagga tgaataaaat ggcattcatc ggaatttgat 91680cttagccatt ctgagtggct
gtgaggtgga atctcagggt tgttttgatt tgcatttccc 91740tgatgattaa ggatgctgaa
cctttttttt ttcaggtgct tctcagccat tcggtattcc 91800tcaggtgata gcccaaaaaa
cttagaatac ccaagataca agatacaatt tgcaaaacac 91860atgaaactca agaagaacga
agaccaaagt gtggacactt tgccccttct cagaactggg 91920aacaaaacac ccatggaagg
agttacagag acaaagtttg gagctgagac gaaaggtgga 91980ccatctagag actgccttat
ccagggatcc accccataat cagcttccaa acgctgacac 92040cattgcacac accagcaaga
ttttatcgaa aggacccaga tatagctgac gaaatccagg 92100cccatccatg ttcctgaaaa
tgtgaagact ccattctttt tatggcagaa tacaattccc 92160atatgtgtat ataccatatt
cttaaaatcc actcttctgt caagggaact ttaggttgat 92220tctatatctt agctattgta
aatagtatag caataaatat ggctgagcaa gtatctctat 92280gttaggatat ggagtccttt
gggtacatga ccaggatttg tataactagt tgtgtgtgtg 92340tgtgtgtgtg tgtgtgtgtg
tgtgtgtgtg tgtgtgtgtg tgtatttgta taactagttg 92400tgtgtgtgtg tgtgtgtgtg
tacccttcaa actgagcttc attgtgaata cactactttg 92460cattgccacc agcagtgtat
aaaggttcct ttcacttctg tattcacacc agcatctgtt 92520gttgtatcta ataggacttt
agaaacattc tttttttttt ttttttcctc attggaccat 92580gtctggctga agtgagttag
ccacctacag gctttcaaag cagaacttcc cgattcatcc 92640tgccaaaagg atatactcat
tcgagagatg gcttcctgtt ggtacacaga aggaacactg 92700aagtaagcct gggacaggat
aaagccaatg tgtcagagac aggaaatctt acttctgagt 92760attcagggag aaaggagcat
tgctcaatgc actaggaatt ctacaaaaat ggttaccccc 92820cccctgagat tacacagcct
aggaaccatg ctggccctca atcagtgcaa ttttgaaact 92880gcaccgctgc accactaaac
aattacactt tccttttaag gctgttaacc tttctgtctg 92940gtagttttaa acacagttat
ctacactgta tatttgccta aaagcagtct ttatggcacc 93000atcacaagct gggtcattcc
atactcattt aaattaaggg aacccagaga aaggaggcga 93060cattcacata tgatgtcctg
taagtgtggt tatttggact ccagagcact tgtctctgta 93120tatctgtaac tttgattctg
catctgatta taaagtggat agttttattt aaaaagcatg 93180gtccggctct cccatttaac
tcgaaaaaga gacacactaa aggagttaat tccaaagtgg 93240ataaattgat attttggcca
gtaagatgag ggcatgaggg gaaagctgca ctcacgtcag 93300ctctgtgccc cactgtgctc
tgccgaccag gtgcaaagag aaatatgagg atctgagggt 93360gctttggttt ttattgccaa
aggcagccgt gatgaacatt ccagaccctg gggcagaagt 93420tagacagagc tgccagaagg
aacaatgaaa gggatcctaa tagtttagtt tgtacataaa 93480accgagccaa ggagaactga
gtaagcacag acggtattac tgtaatacat ctgatatgtt 93540tacatcgacg ttttactctg
caactctctc atagtgtggc agttcttttg cacctgtgtt 93600ctgggaattc tacaacttga
actggagaaa acaatttcac tatagttttg gccatagaag 93660ggtttatgaa tgctgacaat
gatccaatta cgttgttaac ctttttgggc tttatgcatg 93720aatgggagtt tgctggtata
gtttaatacg acccagagtc caactccaaa taataccgca 93780cagcaacctg acaaggtgtc
aaatggagtg ggaatctatc acttctcttg aagtagcaat 93840gaactaaaaa tctcaataca
actttagata ctacagttgc tcactacagg atctagctca 93900tccagattat acacgtccaa
atgatgtaaa cagcacgcat gtgtgtgtgt gtgtatgctt 93960atgtgtatgt ttctctgtgt
gcatttgtgg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg 94020tgtgtgtatt tgaatgctgg
cctctatcca atgctctggt ctggatgatg caattgccat 94080tgtctccaaa aaaaaataga
atgttttccc atttggaaat ggcacaatta attgaagcag 94140aaatgctcat ctttacttgc
agtttggcat tatttcaaag tttataaata atgattttta 94200ggcttgatca atgatttaaa
gtcttctgca cacctatcca ttcattttaa caaagaattc 94260tctgcagtgt tttacatcat
tcaagataat ttatccccat caatcctcta gtaaaaaaac 94320tatgattaat tcattcacaa
aatatctagt gctccatatg caaatgatgg gaggtcacag 94380aaggccagaa aaggaagaaa
ctttcaaaac agaccaaaaa gggggtgggg ggaccaaaaa 94440gagagccaca gagaattgga
aaatccagtg aaggtggatt acaggacaga aagatggctt 94500gtcaggtaag ggagcttgct
tctaggcctg aggacttgaa ttcagtcctt ggaatataca 94560cagtggagga gagggccaat
tgccaaaatt gttttctgat cttcacataa gggatatagt 94620taacatgtac attctcacac
acatgtataa acacacagac acacacagac acacacacgg 94680ttaaattttt gaggcgatta
caaacaatga ggctagcaca ctgacaatct gctggatttg 94740accttgggta aggatgatta
gtcagatggg cctctatctt ccagaaacca cagttgcaat 94800tatttacaag tttttacttg
ttccccatta ctatctcaat gtggattgat actcaaatca 94860ccaacaattc cccaattggt
cttttatgtt atatttgcta taaaaacaag agtaatggct 94920cttggtattt tcttaagtaa
taaaatcggc tttctgattt ttctaagaaa attgggaaga 94980cagtgtgata atgagagctg
tattccatat ttgacttaca cagagtaaat tctgagacta 95040attctgttta aaatttaaat
agaatatttt tccatttatt ggtagtcagc agctcactat 95100gttacccagg ctctccctga
agaatccatc ctctgccaga aaatccccag tgctgattgt 95160gtgtgtgtgt gtgtgtgtgt
gtgtgtgtgt gtgatcacat ccatatcctg accacaaacc 95220tcaatcactt ctcataagct
tgttttatgc tccagataac agtaacttca aacttgacct 95280gagggagctt ttactgtaat
actctcctgg aggaaacaaa gcagaacaga ttaaaaacct 95340attgtttcta aaaccccaga
cagcaactta acacaaacag tttgttggga ggctctctga 95400agttgctctt tcaatgcctc
tcattcccaa gccccaaact gccttggact ttacactgtt 95460tcttttctag ttttaaaaaa
ccagcactta cacaatcaca aggccatttc atttgcttgc 95520cctctttggt taaataagtt
attaaaacaa tcagggagcg gaccttcaag agtttccatt 95580tttaaaagaa agcggaagtg
aacccctggg aggaggggtg aacttatgag gatgtaacat 95640ttcctactaa ggcctgagaa
agaattcatt gattgaattt acaacaatga ggagttacct 95700ctgtgctgtg agttttctta
gctcccgcta gcctgggaat gttattttcc tcacgaattc 95760tcagactcgg aagacatgga
caacttcggg aagaggaaaa ggaagaacta gagtctagga 95820acctatgatg tgaagcagga
aattcttttc aactgtactg actgaaaaga atagcttgct 95880ggtgcccaac atattccagc
acctctttgg aagtccctta atagtgtggc attttcccat 95940ggatgggtga ttattttgca
ggaagataaa ataaaaaagg taaaggacag gaaagaacat 96000ggcgccaaat gaagtaaaaa
gaaataaaag aaagagatga ctgctcctgg gtatggtaga 96060ggagaaaggt ttttatagat
acgtggggga gcatagccag aggcaagaac cttagagaga 96120gagtctggag tggacatgaa
cacactgcca tgtgtcatgt gaggagaaag gtgaaggagg 96180gcaagagaga ggtgagagag
aagaaccacg ttcaggagtc aggaggctca aagttacaaa 96240gagaaaggat aaccaaagtg
gttggattat ttagggagga gcggcctgtg ccagagagtt 96300cagagtaagg gttgaggaat
gccacccagg tgggtcctat aacagggagg gactggtgga 96360tacagggaac ttgggggcca
ggtctgttgt gatatgttag ataggtatct cagccatttg 96420tcccaggttt caaacatagc
acagattatt tttcaaatag ctacaaatat caatttctga 96480aatgagttag gttttaagtg
cgaagccaac aaaatctatg tgcttcttga aatgttgttg 96540taccttcaag aaccaatttc
caactcaggt accaaatgaa acgcttctca accctcatct 96600ctccagagct gctccttagc
tatctttcct tcatgcatgc ctttcatttt tccagaagac 96660acacacacac acacacacac
acacacactc tctctctctc tctctctctc tctctctttc 96720tttctttctt cttttttttt
tggttgtttt tttcggaaca gggtttctct gtatagccct 96780ggatgtcctt tgtagatcag
gctggcctcg aactcagaaa tccacctgcc tctgcctccc 96840aagtgctggg attaaaggcg
tgcgccccca ccgcccggca tcctttttct ttaatgcttc 96900ctgctccctt ttttatatac
cagggcatga tatcctcttt ggttcaaata gcttttatga 96960ctctgatggc tccttcctca
gtcaattatc acaaaataac ttggaattcc tttttaaaaa 97020gtattctttg agaatattaa
taattaggat aaatgtaata gtagatactg ttcctgccat 97080ttttctactc ataaataatt
acctagtact tacttagaat acacttactt ccactccaaa 97140ggatttacaa agcagcaggt
aaatagatac tcttaaattt tgttaagaat tacttctaat 97200ggtatgtacg actgttttta
aaatggccac aattaattga gtaatttttt ttttaatgag 97260tatcttaact agaacaatat
ctgatccctg gaaataaata atctggtggt aagtttcttg 97320aatttatttc ccatctgaaa
attactatac atgataggat ataattttac atcacattac 97380aatgaataat attttgtaaa
ttccagtcat actaaaattg cattaggaac atggcattag 97440ttctgaaaac attaccagcc
ataatgcaaa ccagacacta atgctttgag aagtaacttg 97500ctgaaatggg atgaaataat
cacgcgatac ataaaccatt tataggattt accttaaagc 97560acaggtgatt tgtttttact
gaagagaaat aattctttct tattattcca aacatcaagc 97620gccatcgcat cataaaaata
aaatatggca catgaacatt ctatttttca tccttttatt 97680catattcgct ttgctatgaa
ataacgaaaa catcatgcat cttcactatt atttcccata 97740ttgtctaatc aacaaggtac
aaacaaatgc agtttcagta gatgagaaag gtcaaggttc 97800tgcaacttgc agtcgccttc
acgttgcatg ctgcgcctga gcagcataaa agacagaagt 97860atcatttagt gccaaaagga
aagggtctga ggcatgaacc cgagagccaa tcctttcaac 97920ttccattctc taacttttct
ttctccatat accatattca tcagcactta agtgaccaac 97980agttaaaacg gatggtttag
gcaaggaaaa acacctctct tgttagtcct aaatactgca 98040gaaatttaga gcttgaaaaa
ttggccaaca gacttacttc tcagtaacca gttttaaatt 98100tccaatcatg aagagggtaa
aatcacaacc tttatgaaca caaaatattt taaaccttac 98160acggaatctc caatatttac
ataaaagaga agcttttaag ctgagtgtat ttgaaagctt 98220agctttattg tgctggggaa
tgtaccatca tcaacaccat tgaatgacat aaaataagct 98280gatatcccca aatccttttt
tattagatat tttcttcatt tacatttcaa atgctatccc 98340gaaagtcccc tctaccttcc
cccacccccc cccgccctgc tccccgaccc tcccaaatac 98400tggaattttt aaagacagta
cttctgaaat ctataggaca agttcaagtc ctggctactc 98460attaaattcc ataagctttc
aggcaaatcg tacccccttt cctctctgtg tgtcttcatt 98520tctgtggact ggttgagatg
tgtgcatgtg gaagcctaag gacaaccttg ttgtcatctc 98580tcagacacca tcccaccatc
tacctttttt tctttggtgg tcagggtttc tcattggcct 98640ggaacttatc aagtatgcta
gcctaaacgg tcagtgaggg cctacctgct ctccttggcg 98700cagagattac aagcatgaac
caccctgact tgtgatttgt tttagaaact taggttctag 98760ggatcaaact tgggtcctca
tgcttgtaag tcaaaccctt taatgcctgg acaatttcat 98820tggtccccac ttctttcttc
ctttcttact ttcacttgca cttgtcactc tggtaagtgg 98880cattctttcc tgtttgtacc
ctgactcctc gatggtaatg tgatggagaa atactgagtt 98940gacttctact caggctattg
tgttacttaa gtgtggttgc tctctgctcc tatgtgaagc 99000tctttagaat tagaaccagc
ccatgctctt ccagtgagtg aaagactaga tcacattgct 99060taaaatcctt gaacttagat
gtgcacctga ataaaggtaa gcatagttct gtctttatga 99120aagatccata agtgatatcg
atataacgtc ttgtttggtt gttgtcgttc cagaattggg 99180gcagaagtgc agattgatta
ctgaatatct ttgctatcta aggtttgata tctatagtta 99240tgcaaataca accaattaga
ggatgggctg taaaaactgt acatgtgaac tacggccaca 99300gtcagggaaa ggactcgtgc
tattattcca tctttgattc tatctatgac atatggctga 99360gcaagtatct ctatgttagg
atatggagtc ctttgggtac atgaccagga tttgtctaac 99420tagttgtgtg tgtatgtgtg
tgtgtgtgtg tgcgtctatt tctttttatt ggggaattga 99480gtcgattgat attaagagat
attaagttaa agtaattgtt gcttccaatt agtataaata 99540tacaaagata aatcataaca
aaatattaag aatgacaaga atagaaaacg tcctatttta 99600ttttactaca cacacacaca
cacacacaca cacacaaaca cacacacact ttcacatgtt 99660taatgtatat ataggttgac
atattctggg ttcacacata tgcaaagagt ggtgagccat 99720caacgagaat aaaagaaaaa
cgaacgtgca cgtagatgct ttcaaaaata atcaacgctc 99780acggaaacca aaaacaagtg
tcctttgaaa aaaagaaaat cgaaaggtca cgaccaccgc 99840attctcctct gtcaccaccg
ggtggcgaca gagagcacgc cgggaaaaaa aaaaaaaaaa 99900cttcctccaa ggggtcggat
ctgcctgctt catcccggcc agggtgaggg gaagccggcc 99960aggctggcgg atccgacccg
gcgaggcggt cgcgttttcc atcggtcggt ccccgggagg 100020ttgtactctg tgagatacag
gaagtgcctc cattttggac aggaagtcgg gcccaggcgc 100080tcatgggagc tgtagtgcgt
ctaggctagg gcccagcgcc gatctccggg gccacccggt 100140ggcgaaaaac acgcaagtgc
acccccggtt ctctgcctcg tggggacgga tctgggaccc 100200gaaggccagc cctggttcca
gacgagcggt gtggccgtgt cggcggcgtc cccgggcaga 100260cgggggttca ggtccgcgcc
cgccgctcca ggttgtacct gtagaagttc agggacagag 100320cctctctctg tctctctctc
tctgtgtcta agtctctctc tctgtccctc tgtctgactc 100380taagtctctc tcctcctcct
cctcctcctc ctcctccctt ccacccgggg ctgcctggcg 100440tcggcgtccg ccatcgaggg
acccatcccg gcttccacga gtcccgcagc ccccggctct 100500cccttctcct cccttctcct
cccttctcct tccttctcct gcttccttct tccatcccgg 100560cctgcctggc ctctgccgtg
gcccgcgcag ctcggctctc tgcgtctgtc tgtccccctg 100620tcctggttct cccttctcca
tcttccttct tccatcccgg cctgactggc ctctgccgtg 100680gcccgcgcag ctcaggtctc
tgcgtctgtc tgtccgtccc cctgtcctgg ttctcccttc 100740tccttccttc tcccttcttc
tccccgggga ccaagcccga gtccgtgtcc cgcgcagtct 100800gggtctctct gtccccctat
ccccctgtcc ccctgtcctg gttctccctg cttccttctg 100860ctccccgggg accaagcccg
agtctgcatc cgaccgagac gcaccatccc ggcttccgtg 100920tgtctctctg tccccgggtc
tctgtctgtc aacctccctt ctccttcctt cttccaccca 100980gggaccaagc ccgagtccgt
gtcccgtgta gttcgggtct ctctgtcccc ctgtccccct 101040gtcctggttc tcccttcttc
ttccatcccg gcctgcctgg tctctgccgt ggcccgcgca 101100gctcgggtct ctgcgtctgt
ctgtccccct gtcccggttc tccctgctcc tgcttccttc 101160ttctccccgg ggaccaagcc
cgagtctgca tccgaccgag acgcaccatc ccggcttccg 101220tgtgtctctc tgtccccggg
tctctttgtc tccatccttc ctccactttc ttccacccag 101280ggaccaagcc cgagtccgtg
tcccgcgcag tctgggtctc tctgccccac tgtccccctg 101340tcctggttct cccttctccc
ttcttccatc ccggcctgcc tggcctctgc catggcccgc 101400gcagctcggg tctctgcgtc
tgtctgtccc cctgtcctgg ttcttccttc tcccttcttc 101460catcttcctt cttccatccc
ggcctgcctg gtctctgccg tggcccgcgc agctcgggtc 101520tctctgtccc cctgtccccc
tgtcctggtt ctccctgctt cctgcttcct tctccccggg 101580gaccaagccc gagtctgcat
ccgaccgaga cgcaccatcc cggcttccgt gtgtctctct 101640gtccccgggt ctctgtctgt
caatctccct tctccttcct tcttccaccc agggaccaag 101700cccgagtccg tgtcccgcgc
agtctgggtg tctctgtccc actgtccccc tgtcccggtt 101760ctcccttatc ctgcttcctt
cttccatccc ggcctgcctg gtctctgccg tggcctgcgc 101820agctcgggtc tctgcgtctg
tctgtccccc tgtcccggtt ctcccttctc cttccttctc 101880attccttctc cttccttctc
cccggggacc aagcccgagt ctgcatccga ccgagacgca 101940ccatcccggc ttccgtgcgt
ctctctgtcc ccgggtctct ctgtctccat ccttcctcca 102000ctttctccca cccagggacc
aagcccgagt ccgtgtcccg cgcagtctgg gtctctctgt 102060ccccctgtcc ccctgtcccc
ctgtcctggt tctccctgct cctgcttcct tcttctcccc 102120ggggaccaag cccgagtctg
catccgaccg agacgcacca tcccggcttc cgtgcgtctt 102180gctgtccccg ggtctctgtc
tgtcaacctc ccttctcctt ccttcttcca cccggggacc 102240aagcccgagt ccgagtcccg
tgtagttcgg gtctgtctgt ccccctgtcc ccctgtcctg 102300gttctccctt ctccttcctt
ctccctgctt ccttcttctc cccggggacc aagcccgagt 102360ctgcatccga ccgagacgca
ccatcccggc ttccgtgcgt ctcgccgtcc ccgggtctct 102420gtctgtctcc atccttcctc
cactttcttc cacccgggga ccaagcccga gtccgtgtcc 102480cccgcagctc aggtctctgt
catctctctg tcccccccgt ctccctacct tctctgtctc 102540gtggggtcga atctgggacc
cgaaccccag cccgggttcc cgacgagagg tgtggctctg 102600tcattggggt ccccgggcag
gcggcgtctc aggtctgcgt cctccgctcc cgttgtacct 102660gtagaagtgt aggagacgag
cctctctctg tctctctgtc tctgtgtctc tctgtctaag 102720tctctctcct cctcccttcc
acccggggct gcctggcgtc ggcgtccgcc atcgagggac 102780ccatcccggc ttccgcgagt
cccgcagccc ccggctctcc cttctccttc cttccttcag 102840acccggcctg cctggtgctt
ggccaccacc tgtgcagccc cgggtctgtc tctctgtctg 102900tccatcctcg cttcaggccg
gggcccagcc cgagagacat cggcccggcc cgtgcatcct 102960ccctgcctcc cccccccccc
cgctgtctct gtctcccccc cctctgtccc atctccctcc 103020ctcctcaccc ggcctgcctg
gcgctgccca tggcctgtgc agcctgggtc tgtgtgtctg 103080tcctggtcct cgctttcttc
cttcagaccc ggcctgcctg gtgcttggcc aacacctgtg 103140cagtttgggg tctgtccatc
tgtctctgtc ccagtctctg cctgtctgtc cctgtctgtc 103200cctcctccct tcagacagac
ccggcctgcc tggtgcttgg ccaacagctg tgcagctcag 103260gtctgtccat ctgtctctgt
cccagtctct ctgcctgtct gtcccggtct ctccttctta 103320aatcttaaag gaaaaatctt
aaaggaaaaa gagtccagcc cgctcctccc ctcgcctgtg 103380ctcccgctct tcccgactcc
cgaaccccga accgaccgcc tgtctgtccc ggactcagtc 103440agctccggac cgagtccgtc
tctctgtcct tctggcagga cgcagacaca cacgcctcac 103500cccacccaga ccgcagccag
ccccggccgg ctcggtccgt ccccgctcgt cccggagccc 103560gtgcacccgc gcaccgtccg
cgcgtaagac agcccgagtc tgagtccgtg cggatgtgcc 103620gggtggggga tggggtggtg
tgcgtgtgag gtagaccaga agtccagaga gaggaaagga 103680cggacgggcg ggggtgaggt
gagggggtgg gggggaagag cgggagcacg ggcgagggga 103740ggagcgggct ggactctttt
tcctttaaga tttttccttt aagatttttc ctttaagatt 103800tttcctttaa gatttttcct
ttaagatttt tcctttaaga tttttccttt aagatttttc 103860ctttaagatt tttcctttaa
gatttttcct ttaagatttt tcctttaaga tttttccttt 103920aagatttttc ctttaagatt
tttcctttaa gatttttcct ttaagatttt tcctttaaga 103980tttttccttt aagatttttc
cttgttaaga tttttccttg ttaagatttt tccttgttaa 104040gatttttcct ttttaaggtc
ttttaagaga cctttggtgt cttttttttt tttacttttt 104100ttttccgctt tcttttttgc
ctttccattc tgaccttctc tgtctctcgc gttagaccgg 104160aaggggcgtg ttctgacact
ttaggggcgg gtctaaggga agaggggtgt ggtctgacac 104220ttttttttta attctttttt
tctccgcttt cttgggtggc ttttccattc tgacctcctc 104280tgtctctccc tctcaggggg
gtgtgtctta gcccagaagg ggcgtgtctc agagcaggag 104340gggtgtggtc tgacactttt
taaaaaactt atttttcctt tttttccctt ttttcctgct 104400ttctggggtg gcttttccat
tgtgaccttc tctgtcgctc tcgttagggc gtgtcctgac 104460acttaagggg cgggtctaag
ggaagagggg tgtggtctga cacttttttt taaattccgc 104520tttcttgggt ggctccctcc
ctctcagtag gatgtgtctt agcccagaag gggcgtggtc 104580tagtactttg ggggcgtgtc
ttagacagga aggggtctcc tctcacactt tggggagtgg 104640tctcagagca ggaggggtgt
ggtctgacac ttttttaaaa actttttttt cctttttttc 104700gctttcttgg gtggattttc
cattctgact ttctctgtct ctgtccattt agggtttttt 104760tgtcctacta ttctcatcac
actctctgtc tgtggaccga aaaggggtgt gatctcacac 104820tttaggggcg tgtctaaggg
aagaggggtg tggtctgaca cttttttttt aaattccttt 104880tttctcccgc tttcttgggt
ggcttttgca ttctgacttt ctctgtccct ctctcttagc 104940ccagaagggg cgtggtctta
gacaggaagg ggtctcatct cgcactttgg gggcctttgg 105000gggcgtgtct cagagcagga
ggggtgtggt ctgacgcttt aggggcgtgt cttaaaccgg 105060gaggggtgtg gtctgacact
tttttaaaaa cttttttttc cctttttttc gctttcctgg 105120ggggattttc cattctgact
ttctctgtct ctgtccattt agggtttttt gtctcactat 105180tctcacactc tgtctgtgga
tgggaggaag gggcgtggtc tcacgcttta gaggcgggtc 105240ttacactggg aggggtctga
agatggcctt ctttttaaac tctcatctct gccacagaag 105300gctgtgcttc cttcctgtac
tttttggagg caggaaggga cctggtctca cactttaggg 105360gcggttttta cattttcttt
atcgtccctg tcttttctgt tccgtctgtc gcagaaggaa 105420gacacacaca catttgcata
tccatttcaa ctgcaatttt attgaggggg acatgtctgt 105480acgcagtcag gccctgttgg
cgtgctcctt cctccgtgag aatcgctccg tcctggcggc 105540ctcggcgaca cgcgcacctg
gaaaagacgg gaagagaggg aggggggtca gcgtctgtgg 105600acgggaccgt ggcgactcgc
tgtttaaggg tgtgagtgtt tggacacccc gcctaattgg 105660agtgtgaggc ggcctcattg
tgctaatcat cagttgcgtg tctgctgcct ccgtgtgcag 105720acctgaggtt cctctgcatc
tcattatgct gctctgagtc taatctgaac atctgggcct 105780ccgtgtgcag acctgaggtt
cctctgcatc tcatgccatt cactgtcctg gtttgtcaag 105840gtctctgtct ctctctctcc
gtgtctctac ctgaacccaa agctcaccct ctccctctgt 105900ctctatatct ctctgtctct
ctctgtctgt ctgtctgtcc ctaactctgt ctctaactgt 105960atctctgtct gtctttctgt
atctgtgtct ctgtttctgt ctctctgtct ccctttctct 106020ctgtcagtct ggctctgtct
ctctctgtct gtttctctgt ctctccatca ctgtctccct 106080ctctatctgt ttctctgtcc
ctccatctct gtatctgtgt ctgtatctct ctgtctcgca 106140gtctctgtgt ctctgtttct
gtctctatct ggctgtctct ctgtctccct ttctttctgt 106200tggtctggct ctgtctgtct
ctctgtctct ctgtctctgt ctaacactgt ctctctctgt 106260gtctctgttt ctgtctgtct
cactttctct atctctctct gtctttctgt ctgtcttact 106320gtctctgtct ttctgcctct
gtctcccttt ctctctgtca gtctggctct gtatctctgt 106380ctgtctgtct ctgtcgctgt
ctgtttctct gtctctccat cactgtctcc ctctctatct 106440gtctctctct atgtctctgt
gtctgtctat ttatctctgt ctctttctct ctctgtttct 106500aactctgtct ctgtctctcc
gtgtctctct accttaaccc taacctcacc ctaaccctaa 106560acctctctgt ctgtttgtct
ctgtctctcc atctctgtct ctatctctct gtgtctctct 106620gtctctgtct ctccgtgtct
ctctacctta accctaacct caccctaacc ctaaacctct 106680ctgtctctcc atctctgtct
ctgtgtctct ttccctaact ctgtctctaa ctgtatctct 106740ctgtctctcc gtctctgtct
ttctctccgt gtctatcttt ctttgtctct ctgtccttaa 106800ctctgtctgt ctccaactct
gttctgcctc agtctctctg tctctatctc tgtgtctgtc 106860tccctctcta tctgtctcta
tatatctctg tctcactctg tctctgtctc tctaccttaa 106920cactaatcat aacctcaccc
taaacttaac cctctctgtg tctgtctctg tctctatctc 106980tctgtctctg tgtttctctc
tctatgtctc tcgatctctg tctttctgtt tctccatctc 107040tgtctctatc tctctgtgtt
tgcctgtctc catcgtctgt ctcactttat ctatatctgt 107100ctttctgtct ctgtgtctgt
ttctgtctct ctgtcagtct ggctctgtag ctctgtctgt 107160ctatttctct gtctctccat
cactgtctcc ctctctatct ttctctctct gtgtctctgt 107220tctgtctgtc tatctatctc
actgtctctg tctctctgtg tctctatgcc tgtctctgac 107280tctgtgtctc taaatctgtc
tctctgtctc tgtctgtttc actttttcta tctctctctg 107340tctttctgtc tctctgtctc
cctttctctc tgtcagtctg gctctgtagc tctgtctgtc 107400tgtttctctg tctctccatc
actgtctccc tctctatctg tctctctctg tttctgtctg 107460tctttcggtc tcattgtctc
tgtctcagtg tctgtctgtc tcagtgtctg tatctctctg 107520tctcgcagtc tctgtgtctc
tgtttctgtc tctatctcgc tgtctctctg tctgtctctc 107580tgtctctgtc tctctctaac
tctgtctaac actgtctctg tgtctctgtt tctgttttaa 107640ccctaaccct aacctcaccc
taaccctaaa cctctctgtc tctccatctc tgtctctgtg 107700tctctctgtg tctgtctctc
cgtgtctctc taccttaacc ctaacctcac cctaacccta 107760aacctctgtg tctctccatc
tctgtctctc tgtctctctg tgtctctctg tctctgtctc 107820tccgtgtctc tctaccttaa
ccctaacctc accctaaccc taaacctctc tgtctctcca 107880tctctgtctc tctctctctg
tgtctctctg tctctgtctc tccgtgtctc tctaccataa 107940cactaacctc accctaaccc
taaacctgtc tgtctctcca tctctgtctc tatctccctg 108000tgtctctctg tctctgtctc
tccgtgtctc cgtctctcta tctgactctc tctctgactc 108060gctgtctgtg tctctctgtc
tctgtatgtc tgtctctata gatatctgtc tctctgtgtc 108120tctgtgtgtc tctgactctg
tctcaatctg tgtctctgta tctgtctgtc tatctatctc 108180actgtctctg tctctctgtc
tctctctctg tctgtctgac tctctgtctg tctctctgtc 108240tctgtctgtc tcgctgtccc
tttgtctgtc tctctgtctc tgtctctctg tctctgtatc 108300tgtctgtctc taactctgtc
tgtgtctgtc tgtctgactc tctgtctgtc tatgtctttt 108360tccctgtctc tctatctctg
tctctctctc ggactgtctc tgtctctttg actctgtccg 108420tatgtgtcta tctctctgtc
tctgtctgtc tctaactctg tctctctgtg tctgtctgtc 108480tgtctctctc tgtctatgtc
tttctccctg tctctctgac tgtgtttgtc tctctgtctc 108540tgtctctctc tcggactgtc
tctctgactc tgtctctctg actctgtccc tatgtctgtc 108600tctctgtctc tgtctgtctc
actgtccctt tgtctgtctc tctgtctctg tctctctgtc 108660tctgtttgtc tctaactctg
tctgtgtctg tctgtctgtc tgtatctgtc tgtctctaac 108720tctgtctctc tgtgtctgtc
tgactgtctg tctctctcta tgtctttctc cctgtctctc 108780tatctgtttg tctctctgtc
tctgtctctc tatctctgtc tctctgactg tctctctgtc 108840tctgtctctc tctttctgtc
actatgtctg tctctgtctg tctgtctcgc tgtgcctttg 108900tctgtctctg tctctctgtc
tctctttgtc tctaactctg tctgtatgtg tctgtctgtc 108960tgactctctg tatctgtctg
tctctaactc tgtcggtctg tgtctgtctg tctgactctc 109020tgtctgtcta tgtctttctc
cctgtctctc tgtctgtttg tctctctgtc tctgtctctc 109080tatctctctc tcggactgtc
tctctgtctc tgtctctcta tctctctctc ggactgtctc 109140tctgtctctc tctctctgtc
tctatctgtc tctaactgtc tctctgtgtc tgtctgactc 109200cctgtctctg tctgtctgtt
tgtctctctg tctctgtctc tctctcggac tgtctctctg 109260actctctctc tctgtctctg
tctctaactc tgtctgtgtc tgtctgtctt tctctctgtc 109320tctgtctgtc tggctgtccc
tttgtgtgtc tctctgtctc tgtctctctg tctctgtctg 109380tctctaactc tgtctgtctg
actctctgtc tctctgtctg tctatgtctt tctccctgtc 109440tctctgtctg tctgtttgtc
tctctgtctc tgtctctctg tctgtctgtc tctaactctg 109500tctgtctgtc tctgtctctc
tgtctctgtc tgtctctaac tctgtctgtc tgactctctg 109560tctctctgtc tgtctatgtc
tttctccctg tctctctgtc tgtctgtttg tctctctgtc 109620tctgtctctc tatctctgtc
tgtctctaac tctgtctgtc tgtctctgtc tgtctctctg 109680tctctgtctg tctcgctgtc
cctttgtgtg tctctctgtc tctgtctctg tctgtctcta 109740actctgtctg tctgtctctg
tctgtgtctg tctgtctgac tctctgtcta tgtctttctc 109800cctgtctgtc tgtctgtctg
tctctctgtc tctgtctctc tctcggactg tctctctgtc 109860tgtctctctg actctgtctc
tctgtctctg tctgtctcta actgtctgtc tgtgtctgtc 109920tgactccgta tctgtctgtc
tctaactctg tgtctatgtc tctgtctctc tatctctgtc 109980tctctctcag actgtctctc
tgtctgtttg tctccctatc tctgtctctc tctcagactg 110040tctctctgtc tgtctctctg
tgaagtaaag ataattagaa gtgaaggtaa ttagagaaaa 110100gaaaaatacc tcgtcttgaa
taaaaccaac aacaataaac aacaacaaca ataaacaatc 110160gcaaggttgc actgacgtcc
tggggccact gggtggcgcc agagcatctg agtgcctcag 110220tgtgcaaatc tgagcgtcgc
attttaatgt ttatgtgaat ttgcatctct gtgtgcctca 110280taatgcaaat ctgtgcgagt
tcactgggtc ctagttaaag tctctgtgag ttacctgagc 110340gcctcattta aatggtggag
caccagagca accctctcag tgtgaagccc agacacaaaa 110400cagaaatcaa ttcaaagaat
tgaattctaa aaattcaaaa aagaatttca caaaaattcc 110460cctgcatcct aacgagtttc
caaggtgctg atttaaacct acacaagttc cctggtaaaa 110520acccgggcgt ggtggctgag
agaaaccaag tctgtcccaa agccaccagg cctctaatcc 110580ctacctaccc tccagagaca
gagccaggtg gatctctgag tcccaggcca gcctgctcta 110640cagagcgagc ttagagaaac
cctttctcca aaaacctgaa aagaaactaa aaataaaaat 110700ccaaaaagag agaaacaggc
agataaataa tcgtttaacc tccaaaaaat taaatctgaa 110760aagtcatcag aaaagaaaaa
aaatatgcca aatcttcgaa aaaaaatctc aaatttcaca 110820gtgacgttct atctccacga
gtttcacggg ttctaattta aacctgcact agttttggaa 110880tctgattcct aatttaaacc
tgcactagtt ttggaaagat caggaattca aggcccatac 110940ctaacatgat aaaagcaatc
tacagcaaac caggagccaa catcaaagta aatggagaga 111000agctggaagc aatcccacta
aaatcaggga ctagacaagg ctgcccactc tctccctacc 111060tcttcaacat agtacttgaa
gtattagcca gagcaattag acaacaacag gagatcaagg 111120ggatacaaat tggaaaagag
gaagtcaaaa tatcactttt tgcagatgat atgataatat 111180gtatacgtga cccaaaaatt
ccaccagaga actcctaaac ctgataaaca gcttcggtga 111240agtagctgga tataaaatta
actcaaacaa gtcaatggcc tttctctaca caaagaataa 111300acaggctgag aaagaagtta
gggaaacaac acccttctca atagtcacaa ataatataaa 111360atatcttggc gtaacgttaa
ctaaggaagt gaaagatctg tatgattaaa aagttcaaat 111420ctctgaagaa agaaattaaa
gaagatctca gaagatggaa agatctccca tgctcatgga 111480ttggcaggat caacattgta
aaaatggcta tcttgccaaa agcaatctac agattcaatg 111540caatccccat caaaattcca
actcaattct tcaacggatt agaaggagca atttgcaaat 111600ttatctggaa taacaaaaaa
cctaggatag caaaaagtct tctcaagggt ttgaaaaaaa 111660atctcaaatg tcgcagggac
cttctatcta cacgagtttc gcgggttcta atttaaccct 111720gcacagattc cctgattcct
aatttaaacc tgcacgagtt tccaaggtgc tgatttaaac 111780ctgtacaagt tccctggtaa
aaacccgggc gtggtggctg agagaaacca agtctgtccc 111840aaagccacca ggcctctaat
ccctacctac cctccagaga cagagccagg tggatctctg 111900agtcccaggc cagcctgcta
tacagagcca gcttagagaa accctttctc caaaaacctg 111960aaaagaaact aaaaataaaa
actcaactaa aataagaata attggggaaa aaaccaagtc 112020tcgcgagcac gggtgtctcc
ggggttaaaa attacaaaat taaaatgttc aacagtgaaa 112080aaaatacaaa aataaaaatt
aaaattaaaa ctgaagaaaa atgacaaatc ttcaaataaa 112140actcaaatat cgtagtgact
ttctatctcc acgagttttg cgggttctaa tttaaacctg 112200cacaaattac tgggttctaa
attaaaccat taatttcaca ctcaaaaata gaaggtgaag 112260ataattagag aaaagaaaaa
tacctagtct tgaataaaaa caacaataaa aaattgcaag 112320cctgcactga cgtcctgtcg
ccactgggtg gcgccagaga cagagtctca cggtgaagca 112380cagagaacac agatcttgca
taaaaaccaa aaaacagatt ccctgcatcc taatttaaac 112440ctgcacagat tccctgattc
ctaatttaat cccacacgag ttcgcctgca tcctgattta 112500aacctgcaca cattcccagg
ttctaaatta aaccttgaat ttcacactca aaaataaaag 112560gtgaagataa gtcgcgaaaa
gaaaaatacc tagtcttgaa tgaaaacaac aataaaaata 112620cggcaatagc ggcttgacaa
cacatctaaa agctctagaa ctaaaggaag caaactcacc 112680caagaggagt agacagatgg
caggaaataa tcaaactcag gggtgaaatc aaccaagtgg 112740aaacaagaag aactattcaa
ggaattaacc aaaccaggag ctggttcttt gagaaaatca 112800acaagataga taaaccctta
gctagactca ctagagggca cagggacaaa atcctaatta 112860acaaaatcag aactgaaaag
ggagacatga caacagatcc ggaagaaatc caaaacacca 112920tcagaaatca aaacacctgt
gcctaaaaac caaataataa aattttttaa agatttgtaa 112980agataaaatt aaaaaaaaat
aattagaaaa aatataaagc attgacaaaa tcccccaaaa 113040ttggaatgtt tatttaaaaa
ttacaaaata aaaatattca acagtcaaaa attcaaaaca 113100aaaaaccctg tctcgaaaaa
aattttttgt ctctgtatgt ctgtgtctct gtctccctgt 113160ctctctgtct ccctgtcttt
gtctgtctgt ctctctgtta agtaaagata attagaagtg 113220aagataatta gagaaaagaa
aaatacctcg tcttgaataa aaccaaccat aaacaatggc 113280aaggttgcac tgacgtcctg
tggccactgg gtggcgccag agcatctgag cgcctcagtg 113340tgcaaatcta agcctcgcat
ttcaaagttt ctgcaaattt gcatctctgt gagcctcatt 113400atgcaaatct gtgcgagctc
cctgggtcct ggttaaagtc tctgtgagtt acctgagggc 113460ctcatttaaa tggtggagga
ccagacacaa aacaaaaatc aattcaaaga gtcagagaga 113520ggctcatctc cctacacttc
tacaggcgca aagggagcag gggatgcgga cctgagatgc 113580cgcctgcccg gggacgccac
tgaggaagcc acacccctcg tcgggagccc gggctgggat 113640tcgggtccca gattcgtccc
catgaggcag agaaggtagg gaggcggggg ggacagagag 113700aggacagaga ccagagctgc
tcgggccacg gacaggaatc aggaattcaa ggcccacagc 113760taaacatgat aaaagcaatc
tacagcaaac caggagccag catcagagta aatggagaga 113820agctggaagc aatcccacta
aaatcaggga ctagacaagg ctgcccactc tctccctacc 113880tcttcaacat agtacttgaa
gtattagcca gagcaattcc acaacaacag gagatcaagg 113940ggatacaaat tggaaaagag
gaagtcaaaa tatcactttt tgcagatgat atgatagtgt 114000atataagtga ccctaaaaat
tccaccagag aactcctaag cctgataaac agcttcgccg 114060aagtagctgg atataaaatt
aactcaaaca agtcaatggc ctttctctac acaaagaata 114120aacaggctga gaaagaaatt
agggaaacaa cacccttctc aatagttaca aatagtataa 114180aatatcttgg cataatgcta
actaaggagg tgaaagatct gtatgataaa aacttcaagt 114240ctctgaagaa agaaattaaa
gaagatccca gaagagcgag cttagagaaa ccctttctct 114300aaaaacctaa aaagaaacta
aaaataaaaa tccaaaaaga aagaaacagg cagataaata 114360atcgtttaac ctccaaaaaa
ttaaatctga aaagtcatca gaaaagaaaa aaaaatgcca 114420aatcttcgaa aaaaatctca
aatatctcag tgacgttcta tctccacgag ttttgcgggt 114480tctaatttaa tcccacacga
gttcgcctgc atcctgactt aaacccgcac aaattcccag 114540gttctaaatt aaaccttgaa
tttcacactc aaaaataaaa ggtgaagata agtcgcgaaa 114600agaaaaatgc ctagtcttga
atgaaaacaa caataaaaaa acggcaatag cggcttgaca 114660acacatctaa aagctctaga
aaaaaaggaa gcaaactcac ccaagaggag tagacagatg 114720gcaggaaata atcaaactca
ggggtgaaat caaccaagtg gaaacaagaa gaactattca 114780aggaattaac caaacgagga
gttggttctt tgagaaaatc aacaagatag ataaaccctt 114840agctagactc actagagggc
acagggacaa aatcctaatt aacaaaatca gaactgaaaa 114900gggagacatg acaacagatc
ctgaagaaat ccaaaacacc atcagaaatc aaaacacctg 114960tgtctaaaaa ccaaataata
aaaatctttt aaagatttgt aaagataaaa tttttaaaga 115020ataattagaa aaaaatataa
agcattgaca aaacccccca aaattggaat gtttatttaa 115080aaattacaaa ataaaaatat
tcaacagtca aaaattcaaa acaaaaaacc ctgtctcgaa 115140aaaaattttt tgtctctgta
tgtctgtgtc tctgtctccc tgtctctctg tctgtctctc 115200tctattaagt aaagataatt
agaattgaag ataattagag taaagaaaaa tacctcctct 115260tgaagaaaac caacaataaa
aaatcgcaag gttgcactga cgtcctgtgg ccactgggtg 115320gcgccagagc atctgagctc
ctcattgtgc aaatctgagc ctcgcatttt aaagtttctg 115380caaatttgca tctctgtgag
cctcattatg caaatctgtg cgagctccct gggtcctggt 115440taaaatctct gtgagttacc
tgagggcctc atttaaatgg tggagcacca gagacaaaac 115500aaaaatcaat tcaaagagtc
agagagaggc tcatctccct acacttctac aggcgcaaag 115560ggagcagggg acgcggacct
gagatgccgc ctgcccgggg acgtcactga ggaagtcaca 115620cccctcgtcg ggagcccggg
ctgggattcg ggtcccagat tcgtccccat gaggcagaga 115680aggtagggag gcgggggaca
gagagaggac agagacacga gctgcggggg ccacggactc 115740aggcttggtc cccgggtgga
agaaagtgga agaaggaagg agaagggcgg ggacagagag 115800acagacagaa acctgcacga
gtttccaagg tgctgattta aaccgacaag ttcccctggt 115860aaaaatccgg gcgtggtggc
ccaggccttc catcccagcc ctggggacac agacgcaggc 115920agatctctga atccgaggtc
agcctggtct ccagagcaca ttgcgggaca gccagggcta 115980cacagagaaa ccctgtgtct
aaaaaccaaa taataaaaaa cttttaaaga tttgtaaaga 116040taaaataaaa aaaataatta
gaaaaaatat aaagcattga aaaaaaccat ccaaaattgg 116100aatgtgtatt aaaaaattac
aaaattaaaa tgttcaacag tcaaaaatac aaaaattaac 116160attgaaactg aaaagaaaaa
taaatgacaa atcttaaaat aaaactcaaa tatctcagtg 116220acattctatc tccacgagtt
ttgcgggttc taatttaatc ccagaggagt tcgcctacat 116280cctgacttaa acccacaaaa
attcccatgt tctaaattaa accttgaatt tcacactcaa 116340aaataaaagg tgaagataag
tagcgaaaag aaaaatacct agtcttgaat gaaaacaaca 116400ataaaaatac ggcaatagcg
gcttgacaac acatctaaaa gctctagaac taaaggaagc 116460aaactcaccc aagaggagta
gacagatggc aggaaataat caaactcagg ggtgaaatca 116520accaagtgga aacaagaaga
actattcaag gaattaacca aacgaggagc tggttctttg 116580agaaaatcaa caagatagat
aaacccttag ctagactcac tagagggcac agggacaaaa 116640tcctaatgaa caaaatcaga
actgaaaagg gagacataac aacagatcct gaagaaatcc 116700aaaacaccaa cagatccttc
tacaaaaggc tatactcaac aaaagtggaa aacctggacg 116760aaatggacaa atttctgcac
agataccagg taccaaagtg taatcagggt caagttgacc 116820atctaaacag tcccatatca
cctaaagaaa tagaagcagt tataaatagt ctcccaacca 116880aaaaaagccc aggaccagac
gggtttagtg cagagttcta cagattccct gattcctaat 116940ttaaccctgc acgagtttcc
aaggtgctga tttaaaccta caagttcccc tggtaaaaat 117000ccgggcgtgg tggcccaggc
cttccatccc agtcctgggg acacagacgc aggcagatcg 117060ctgaatccca ggtcagcctg
gtctccagag cacattgcgg gacagccagg gctacacaga 117120gaaaccctgt gtctaaaaac
caaataataa aaatttttta aagatttatg aagataaaat 117180taaaaaaata attagaaaaa
tataaagcat tgaaaaaaac catccaaaaa tggaatgtat 117240attaaaaaat tacaaaatta
aaatgttcaa cagtcaaaaa tacaaaaatt aaaattaaaa 117300ttgaaactga aaagaaaaat
aaatgacaaa tcttcaaaaa atctcaaata tcgcagtgac 117360attctatctc cacgagcttt
gcgggttcta atttaaacct tcacgagttt ctctgcaccc 117420taatttaaac ctgtctctct
gtctctgttt ttttgtttct gtctgtctgt ctctctgtct 117480gtatccctga gcgcaggaaa
taatcaaact caggggtgaa atcaaccaag tggaaacaag 117540aagaactatt caaggaatta
accaaacgag cagctggttc tttgagaaaa tcaacaagat 117600agataaaccc ttagctagac
tcactagagg gcacagggac aaaatcttaa tcaacaaaat 117660cagaaaatta gtgcagagtt
ctatcagacc ttcaaagaag atctaattcc agttctgcac 117720aaactattcc acaaaataga
agtagaaggt cctctaccca actcacttta tgaagccact 117780attactctga tacctaaacc
acagaaagac ccaacaaaga aagagaactt cagaccaatt 117840tcccttatga atatcgatgc
aaaaatcctc aataaaattc tcgctaacca aatccaagaa 117900cacattaaag caatcatcca
tcctgaccaa gtaggtttca tcccagggat gcagggatgg 117960tttaatatac ggaaatccat
caatataatc cattatgtaa acaaactcaa agacaaaaac 118020cacatgatca tctcgttaga
tgcagaaaaa gcatttgaca agatcaacac ccattcatta 118080taaaagttct ggaaagatca
ggaattcaag gcccacagct aaacatgata aaagcaatct 118140acagcaaacc aggagccagc
atcagagtaa atggagagac gctggaagca atcccactaa 118200aatccaaaaa ttaaaatcca
aaaagaaaga aacaggcagg tgaatcaatg tttaacctcc 118260acaaaattaa agataattag
aagtgaagat aattagagaa aacaaaaata cctcctcttg 118320aagaaaacca acaataaaaa
atcgcaaggt tgcactgacg tcctgtggcc actgggtggc 118380gccagagcat ctgagctcct
ccttgtgcaa atctgagcgt cgcattttaa agtttctgca 118440aatttgcatc tctgtgagcc
tcattatgca aatctgtgcg agctccctgg gtcctagtta 118500aaatctctgt gagttacctg
agcgcctcat ttaaatggag gagcaccaga cacaaaacag 118560aaatcaattc aaagagtcag
agagaggctc atctccctac acttctacag gcacaaaggg 118620agcaggggac ggggacctga
gaagccgact gcccggggac cccactgagg aagccacacc 118680cctcgtcggg agcccgcgct
gggattgggg tcccagattc gtccccatga ggcagagaag 118740gtagggaggc ggggggacag
agagatgaca gagaccggag ctgcgggggc cacggactca 118800ggcttggtcc ccgggtggga
gaaagtggaa gaaggatgga gaagggcggg gacagagaga 118860cagacagaaa cctgcacgag
tttccaaggt gctgatttaa acctacaagt tcccctggta 118920aaaatccggt aaaaaaagca
tttggcctca gtgtgaagcc cagaggcaaa acagaaatca 118980atttttgtat aggtttaatt
cttgtataga tttaaacctt gtataggttt aaatcaggcc 119040tctggtccct gccctgagag
agggacagag ccaggtggat ctctgagtcc caggccagcc 119100tgctctacag agcgagttta
gagaaaccct ttctctaaaa acctaaaaag aaactaaact 119160aaaataagaa taattgggaa
aaaaaaccaa gactcgcgag cacgggtgtc tcggggttaa 119220gtcccgagaa agcaagtctg
caaagatcca aaaattaaaa tacaaaaaga aagaaacagg 119280caggtgaatc aatgtttaac
ctccaaaaaa ttaaaactga aaagtcatca gaaaaggaaa 119340aaatatgcca aatcttcgaa
aaaaaatctc aaatgtggca gtgacgttct atctccacga 119400gtttcgcggg ttctaattta
aacctgcaca gattccctga ttcctaattt aaacctcaca 119460gattccctga ttcctaattt
aaacctgcac agattccctg tttcctaatt taaacctgca 119520cagattccct gattcctaat
ttaaacctgc acagattccc tgattcctaa tttaaacctg 119580cagagattcc ctgattccta
atttaaacct gcacagattc cctgattcct catttaaacc 119640tgcacagatt ccctgcatcc
taatttaaac ctgcacagat tccctgcatc ctaatttaaa 119700cctgcacaga ttccctgatt
cctaatttaa acctgcacag attccctgat tcctaattta 119760aacctgcaca gattccctga
ttcctaattt aaacctgcac gagtttccaa ggtgctgatt 119820taaaccgaca agttcccctg
gtaaaaatcc gggcgtggtg gcccaggcct tccatcccag 119880ccctggggac acagagtccg
gcagatctct gaatccgagg tcagcctggt ctccagagca 119940cattgcggga cagccagggc
tacacagaga aaccctgtgg ctaaaaacta aataatgaaa 120000aatttttaaa gatttgtaaa
gataaaataa aaaaaataat tagaaaaaat ataaagcatt 120060gacaaaaccc cccaaaattg
gaatattaaa aaattacaaa ataaaaatat tcaacagtca 120120aaaattcaaa tttaagatga
aaattaaaat taacattcta tctccatgag ttttgcgggt 120180tctaatttaa acctgcacga
gtttctctgc accctaattt aaacctgtct ctctgtcttt 120240ctctctgtta agtaaagata
tttagaagtg aagataatta gagaaaagaa aaatacctca 120300tcttgaagaa aaccaacaag
aaacaatggc aaggttgcac tgacgtcctg tggccactgg 120360gtggcgccag agcatctgag
cgcctcagtg tgcaaatctg agcatcacat tttaaagttt 120420ctgcaaattt gcatctctgt
gtgcctcatt atgcaaatct ctgtgagtta cctgagggcc 120480tcattgaaat ggtggagcac
cagagcaacc ctctcagtgt gaagcccaga cacaaaacag 120540aaatcaattc aaagagtcag
agagaggctc atctccctac acttctacag gcgcaaaggg 120600agcaggggac gcggaccatt
atataaacaa actcaaagac aaaaaccaca tgatcatctc 120660atcagatgca gaaaaagcat
ttgacaagat ccgacaccca ttcatgataa aagtcttgga 120720aagatcagga attcaaggcc
cacacgtaaa catgataaaa gcaatctaca gcaaaccagg 120780agccagcatc agagtaaatg
gagagaagct ggaagcaatc ccactaaaat cagggacgag 120840acaaggctgc ccactctctc
cctacctctt caacatagta cttgaagtat tagccagagc 120900aattccacaa caacaggaga
tcaaagtcac caggcctctg gtccctgccc tgagagaggg 120960acagagccag gtggatctct
gagtcccagg ccagcctgct ctacagagcg agcttagaga 121020aaccctttct ccaaaaacct
aaaaagaaac taaaaataaa aatccaaaaa gaaacaggca 121080gataaataaa cgtttaacct
ccaaaaaatt acatctgaaa agtaatcaga aaagaaaaaa 121140atatgccaac tcttcgaaaa
aaatctcaaa tgtcgcagtg acgttctatc tccacgagtt 121200tcgcaggttc taatttaaac
ctgcacagat tccctgattc ctaatttaaa cctgcacaga 121260ttccctgatt cctaatttaa
acctgcagag attccctgat tcctaattta aacctgcaca 121320gattccctga ttcctaattt
aaacctgcac agattccctg catcctaatt taaacctgca 121380cagattccct gattcctaat
ttaaacctgc agattccctg attcctaatt taaacctgca 121440cagattccct gattcctaat
ttaaacctgc acagattccc tgattcctaa tttaaacctg 121500cacagattcc ctgattccta
atttaaacct gcagattccc tgattcctaa tttaaacctg 121560cacagattcc ctgattccta
atttaaacct gcacagattc cctgattcct aatttaaacc 121620tgcacagatt ccctgattcc
taatttaaac ctgcagattc cctgattcct aatttaaacc 121680tgcacagatt ccctgattcc
taatttaaac ctgcacagat tccctgattc ctaatttaaa 121740cctgcacaga ttccctgatt
cctaatttaa acctgcagat tccctgattc ctaatttaaa 121800cctgcacaga ttccctgatt
cctaatttaa acctgcacag attccctgat tcctcattta 121860aacctgcaca gattccctga
ttcctcattt aaacctgcac agattccctg attcctcatt 121920taaccctgca cagattccct
gattcctcat ttaaacctgc acagattccc tgattcctca 121980tttaaacctg cacagattcc
ctgattccta atttaaacct gcacagattc cctgattcct 122040aatttaaacc tgcacagatt
ccctgcatcc taatttaaac ctgcagattc cctgattcct 122100aatttaaacc tgcacagatt
ccctgattcc taatttaaac ctgcacagat tccctgattc 122160ctcatttaaa cctgcacaga
ttccctgatt cctaatttaa acctgcacag attccctgat 122220tcctaattta aacctgcaga
ttccctgatt cctaatttaa acctgcacag attccctgat 122280tcctcattta accctgcaca
gattccctgc atcctaattt aaacctgcac atattccctg 122340attcctcatt taaacctgca
cagattccct gattcctaat ttaaacctgc acagattccc 122400tgattcctca tttaaacctg
cacagattcc ctgattcctc atttaaacct gcacagattc 122460cctgattcct aatttaaacc
tgcacagatt ccctgattcc tcatttaaac ctgcacagat 122520tccctgattc ctaatttaaa
cctgcacaga ttccctgatt cctaatttaa acctgcacag 122580attccctgat tcctaattta
aacctgcaca gattccctga ttcctaattt aaacctgcac 122640agattccctg attcctaatt
taaacctgca cagattccct gattcctaat ttaaacctgc 122700acagattccc tgcatcctaa
tttaaacctg cccagattcc ctgattccta atttaaacct 122760gcacagattc cctgattcct
aatttaaccc tgcacagatt ccctgattcc taatttaaac 122820ctgcagagat tccctgattc
ctaatttaaa cctcacagat tccctgattc ctaatttaaa 122880cctcacagat tccctgattc
ctaatttaaa cctgcacaga ttccctgatt cctaatttaa 122940acctgcacga gtttccaagg
tgctgattta aacctacaag tttccctggt aaaaatccgg 123000gcgtggtggc ccaggccttc
catcccagcc ctggggacac agacgcaggc agatctctga 123060atcccaggtc agcctggtct
ccagagcaca ttgcgggaca gccagggcta cacagagaaa 123120ccctgtgtct aaaaaccaaa
taataaaaat tttttaaaga ttggtaaaga taaaataaaa 123180aaaaataatt agaaaaaata
taaagcattg acaaaaaccc ccaaaattgg aatgttaaaa 123240aattacaaaa tataaataat
caacagtcaa aaattcaaat ttaagattaa aattaaaatt 123300aaaactgaaa agaaaaataa
atgccaaatc ctctaaaaaa tctcaaatat ctcagtgaca 123360ttctatctcc acgagttttg
cgggttctaa tttaatccca cacgagttcg cctgcatcct 123420gacttaaacc cacacaaatt
cccatgttct aaattaaacc ttgaatttca cactcaaaaa 123480taaaaggtga agataagtcg
cgaaaagaaa aatgcctagt cttgaatgaa aacaacaata 123540aaaatacggc aatagcggct
tgacaacaca tctaaaagct ctagaactaa aggaagcaaa 123600ctcacccaag aggagtagac
agatggcagg aaataatcaa actcaggggt gaaatcaacc 123660aagtggaaac aagaagaact
attcaaggaa ttaaccaaag gaggagctgg ttctttgaga 123720aaatcaacaa gatagataaa
cccttagcta gactcactag agggcacagg gacaaaatcc 123780taatgaataa aatcagaact
gaaaagggac acatagcaaa gtctgcgaag atccaaaaat 123840taaaatccaa aaagaaagaa
acaggcagat aaataaacgt ttaacctcca caaaattaaa 123900gataattaga agtgaagata
attagagaaa acaaaaatac ctcttcttga agaaaaccaa 123960caagaaacaa tggcaaggtt
gcagtgacgt cctgtggcca ctgggtggcg ccagagcatc 124020tgagctcctc attgtgcaaa
tctgagtgtt gcattttaaa gtttctgcga atttgcatct 124080ctgtgagcct cattatgcaa
atctgtgtga gttccctggg tcctggtaaa agtctctgtg 124140agttacctga gagcctcatt
taaatggtgg agcaccagag caaccctctc agtgtgaagc 124200ccagacacaa aacagaaatc
aattcaaaga tgtttccttt caaaaaagtc aagaaacaat 124260ttcaaaaaat ttcctccgca
tcctaaaaag tttccaaggt gctgatttaa acctgtacaa 124320gttccctggt aaaaacccgg
gcgtggtggc tgagagaaac caagtctgtc ccaaagccac 124380caggcctcta atccctaccc
accctccaga gacagagcca ggtggatctc tgagtcccag 124440gccagcctgc tctacagagc
gagtttagag aaaccctttc tccaaaaacc taaaaagaaa 124500ctaaaaataa aaactcaact
aaaataagaa taattgggga aaaaaccaag actcgcgagc 124560acgggtgtct cggggttaag
cccccagaaa gcaagtctgc aaagatccaa aaattaaaat 124620ccaaaaagaa agaaacaggc
aggtgaatca atgtttaacc tccaataaat taaaactgaa 124680aagtaatcag aaaaggaaaa
aatatgctga aatttcgaaa aaaaatctca aatgtggcag 124740tgacgttcta tctccacgag
tttcgcgggt tctaatttaa acctgcacag attccctgca 124800tcctaattta aacctcacag
attccctgat tcctaattta aacctgcaca gattccctga 124860ttcctaattt aaacctcaca
gattccctga ttcctaattt aaacctgcac agattccctg 124920aaacctaatt taaacctcac
agattccctg catcctaatt taaacctgca cagattccct 124980gattcctaat ttaaacctgc
acagagtttc caaggtgctg atttaaccct acaagtttcc 125040ctggtaaaaa tccgggcgtg
gtggcccagg ccttccatcc cagccctggg gacacagacg 125100caggcagatc tctgaatccc
aggtcagcct ggtctccaga gcacattgcg ggacagccag 125160ggctacacag agaaaccctg
tgtctaaaaa ccaaataata aatttttttt aaagattggt 125220aaagataaaa taaaaaaata
attaggaaaa atataaagca ttgacaaaac cccccaaaat 125280tggaatgttt atttaaaaat
tacaaaataa aaatattcaa cagtcaaaaa ttcaaattta 125340agattaaaat taaaactgaa
aagaaaaata aatgccaaat cctctaaaaa atctcaaata 125400tctcagtgac attctaacaa
catgagcttt gcgggttcta atttaaacct gcacgagttt 125460ctctgcaccc taatttaaac
ctgtctctct gtctttctct ctgttaagta aagatattta 125520gaagtgaaga taattagaga
aaagaaaaat acctcttctt gaagaaaacc aacaagaaac 125580aatggcaagg ttgcactgac
gtcctgtggc cactgggtgg cgccagagca tctgagctcc 125640tcagtgtgca aatcttagag
tcacatttta aagtttctgc aaatttgcat ctctgtgagc 125700ctcattatgc aaatctgtgc
gagctccctg ggtcctggtt aaaatctctg tgagttacct 125760gagcgcctca tttaaatggt
ggagcaccag agacaaaaca aaaatcaatt caaagagtca 125820gagagaggct catctcccta
cacttctaca ggcgcaaagg gagcagggga cgcggacctg 125880agacaccgcc tgcccgggga
cgccactgag gaagtcacac cccttgtcgg gagcctgggc 125940tgggattggg gtcccagatt
cgtccgcatg aggcagagaa ggtagggagg cggggggaca 126000gagagatgac agagacccga
gctgcggggg ccacggactc gggcttggtc cccgggtgga 126060agaaagtgga agaaggaagg
agaagggcgg ggacagagag acagacagaa acctgcacga 126120gtttccaagg tgctgattta
aacctacaag ttcccctggt aaaaatccgg taaaacaagc 126180atttgacctc agtgtgaagc
ccagaggcaa aacagaaatc aatttttgta taggtttaat 126240tcttgtatag atttaaacct
tgtataggtt taaatcaggc ctctggtccc tgccctgaga 126300gagggacaga gccaggtgga
tctctgagtc ccaggccagc ctgctctaca gagcgagctt 126360agagaaaccc tttctccaaa
aacctaaaaa gaaactgaaa gtaaaaactc aactaaaata 126420agaataattg gggaaaaaac
caagtctcgc gagaacgggt gtctcggggt taagccccca 126480gaaagcaagt ctgcgaagat
ccaaaaatta aaatccaaaa agaaagaaac aggcaggtga 126540atcaatgttt aaccttcaat
aaattaaaac tgaaaagtaa tcagaaaagg aaaaatatat 126600gctgaaattt caaaaaaaaa
aaactcaacg tcacagtgac tttctatctc cacgagtttt 126660gcgggttcta atttaaacct
gcacagattc cctgattcct catttaaacc tgcacagatt 126720ccctgattcc tcatttaaac
ctgcacagat tccctgattc ctaatttaaa cctgcacaga 126780ttccctgatt cctaatttaa
acctgcacag attcgctgat tcctaattta aacctgcaca 126840gattccctga ttcctaattt
aaacctgcac agattccctg attcctaatt taaacctgca 126900cgagtttcca aggtgctgat
ttaaacctac aagtttccct ggtaaaaatc cgggcgtggt 126960ggcccaggcc ttccatccca
gccctgggga cacagacgca ggcagatctc agaatccgag 127020gtcagcctgg tctccagagc
acattgcggg acagccaggg ctacacagag aaaccctgtg 127080tctaaaaacc aaataataaa
atttttaaag atttgtaaag ataaaataaa aaaaaataat 127140tagaaaaaat ataaagcatt
gacaaaaccc cccaaaattg gaatgtttat ttaaaaatta 127200caaaataaaa atattcaaca
gtcctagttt aggagttctg tggtggaatg tttaggttca 127260cttatatata ctatcatatc
atctgcaaaa aagtgatatt ttgaattctt cttttccaat 127320ttgtatccac ttggtctcct
ttcgttgtca aattgctctg tctaggactt caagaacaat 127380gttgaatagg tagggagaaa
gtgggcagcc ttgtctagcc actgatttta gtgggattgc 127440ttccagcttc ataccattac
atttgatgtt gggtactgat ttactgtaaa ttgcttttat 127500cctgttatgc cttgaattcc
tgatccttcc aagactttta tcatgaatgg gttttggatt 127560tacttaaatg atttctttgc
atctaatgag aagatcatgt ggttttgtct ttgaggttgt 127620ttatataatg gattatgttg
atggattgcc atatattaaa ccatccctgt acacctggta 127680taaaacctac ttggtaaggt
tgaatgaaat ttttaatgtg ttcttggata tgattaggga 127740taattttact gagtattttt
gtttcaatat tcataagggc gattgttcta aagttcttta 127800tctttgttgg atctttctgt
ggtttaggta tcagagtaat atggcttcat agaatgagtt 127860gggtagagta ccttctactg
ctattttgtg gaatttttgt gcagaactgg atttagatat 127920tctttgaagg tctgacagaa
ctctgcacat taaacccatc tgttcctggg cctttttttt 127980ttttttttgg ttgggagact
attaatccct ccttctattt ctttagggta tatgggactg 128040tttagatcgt taacttgatc
ctgttttaac tttgttacct ggtatctgtc tagaaatttg 128100tccattttgt ccatgttatc
ctgttctgtt gagtatagcc tgtggtagaa ggatctgatg 128160gtgttttgga tttcttcagg
atctgttttt atttctctct tttcaattct gattttgtta 128220attaggatgc tgtctctgtg
ccttaaggga tgctagctaa gggtttatct atcttgttga 128280ttttctaaaa gaaccagctc
ctctttggtt gattctttaa gtagttcttg tttccacttg 128340gttaatttca cccctgagtt
tgattatttc cttccatcta ctcctcttga gtgaatttgt 128400ttcctttatt ctggagattt
tttatgtgtt ttcaagctgc ttgtatgtgc tctctctggt 128460ttcttttttg aggcactcaa
atgtatgagt ttccctctta gtaatgattt cattgagtct 128520cataagttag ggaatgttat
ggctttattt tcattaaact ctaaaatgtc tttaatttcc 128580ttctatatcc cttccttgac
caaggtatca ctgaaaagac tgttgttcat tttcaaagta 128640aacgttggct ttccattatt
tatgttgtta ttgaagatca atcatcctta gtccttggtg 128700gtctgatagg atgttttgga
caattgcaat attttttatc agttgaggcc tgttttatga 128760ccaattatat ggtcaatttt
ggaaaaggta cgatgatgtg ctgagaaaaa gttacatcct 128820tttgtttcag gataaatgtt
ctgtagatat ctattaagtc catttgttta ataacttccg 128880ttagtttcac tgtgtccctg
tttagtttct gtttccaaaa tatgtccatt gataaaagtg 128940gttttttaag cctcccacta
ttattgtgtg agctgcaatg tgtgctttga gctttcttta 129000atgaatgaga atgcccttgc
atttggagca tagatattca gatttgagag ttcctcttgg 129060aagattttaa ctttgctgag
tatgaagtgt ccttctttgt cttttttgat aactttaggt 129120tggaaatcaa ttttaatcga
tatttgaatg gttactccag ctgatttctt cagaccattt 129180gcttggaaaa ttattttcta
gcctttcact ctgagatagt gtctgtcttt ttccctgaga 129240tgggtttcct gtaagcagca
gactattggg tcctgttttt atagccagtc tatgtctttt 129300tattggggac ctgaatccat
tgatattaag agttattaag gaaaagtaat tgttgcttgg 129360tatcattttt gttgttagag
tttgcattct gttcttgtgg ctgtcttctt tttggtttgt 129420tgagggatta ctttcttgct
ttttctaggg cgtggtttct gtccttgtat tgttattttt 129480ttctgttatt attctttgaa
gggctggatt tatggaaaat taatgtgtga atttgttttt 129540tatcgtgaaa tactttggtt
tctccatcta tggtaattga gagtttggct gggtttaata 129600gcctgggctg gcatttgtgt
tctcttagta tctgtataat atctgtccag gatcttctgt 129660ctttcatagt ctctggtgaa
aagtctggtg taattctgat aggcctgcct ttatatgtta 129720cctgaccgtt ttcccttact
acttttaaca ctatatctct atttagtgta tttcttcttc 129780tgattattat gtgtcaggag
gaatttcttt tctggtccag tctatatgga attctgtagg 129840cttcttttat attcatgggc
atgtgtttct ttaggtttga caagttttct tctataattt 129900ttttgaagat atgtgctggc
cctttaagtt gaaaatcttc attctcatct actcctatta 129960ccagtaggtt tagacttcat
attgtgttct ggatttcctg gatgtttgag ataagatctt 130020ttgcattttg tattttattt
gattgttgtg ccgatgttct ctatggaatc ttctgcatct 130080gtcattctct cttccatgtc
ttgtattctg gtgctgatac tcgcatctat ggttccagat 130140ttcttgccta ggtattctat
ctccagcgtt gcctcacttt gggttttctt tattgtgtct 130200acttcacttt ttaggtcttg
gatggtttta ttcaattcca tcacctgttt ggtcgtgttt 130260tccttcaatt ctttaagttt
tttttttttt ttgcttcctc ttaaggttct acctatttag 130320cagtattctc ctgtatttct
ttaagtgagt tattaaagtc cttcttgatg tcctctacca 130380tcaacctgag atatgctttt
aaatctggga ctaccttttc gggtgttttg gcgtttccag 130440gactgggtga ggtgggagtg
ctgtaattct gatgatggtg agtggtcttg gtttctgtta 130500gtaagattat tatgtttgcc
tttcatcatc tggtaatctc tggagttagt tgttataatt 130560gtgtctggtt atatcttgtt
cctcagtgat tatgttatcc tctatcagca gacctgggag 130620acttgttttc tcctgagttt
cagtgttcag agtactctat gcaggcaaga tctccacttg 130680cagagaaggg gcccagatat
ctggtgtttg aaccttcctc ctggcacatg ttgtgatcca 130740ctcactagag atactaacat
cccatggaga gtcctgtggg gacctttggg gtgtccacag 130800actctgccgc caaggtgccc
agtgctgtcg tggactggaa gggacttgtg accctggtca 130860gaccggtttc tctgatcacc
taattaatgc agtcacaggt cctgcttgat aggattggag 130920cagaagttgt tttccactca
ccaaaggtct taagatctgg tggatgtttc tgtgaggacc 130980ttggggttgt cctcagtctc
tgcccaaaat gttgcccagg tgctggcaca gaccagaggg 131040acttgtgacc attgtcaggc
cagtttttct gcttccctaa ttaatgcagt ctcagatcct 131100gtgagattgg attggagcag
aggttgtttt ccattcacga gaggtcttat gatcctaaaa 131160agggtcttgt ggggacctta
ggagtgtctg cagactccga tcccaatgtg ccctgttgct 131220ggcttgtcag tctctctctt
atggtacacc ttctctgcct ccttaaagag atgttgtaaa 131280gataatgttt tcagactctc
tagatgctgt aaccttttcc taatttcaga agaggactgc 131340cgtatagaag ccatgacacc
tgttacttgc tggcacgctg aagtagggtc aaagatagtg 131400taacacttct atacctttaa
gaggtagtct aaaatcactg ctgggggctc ctttttctct 131460tgtaggatct ctattacctt
ggccaaattg gtggggcacc tgccagctcc tttcagtcct 131520attatcagag cccagcagaa
aattgtcaat tgctccatat ggtcagtttt gtcaggacat 131580gtcagaggga aggctgcatc
tatttcattc agaagtttta ttggtagtca attggcccac 131640agcatgctct ttctttcctc
tcagaatccg atccttctcc tctgtggtga aagaacctgt 131700aaaagctgct gacagtcatc
acaagtaggc tgaagagaga atatgagaga ttccattaga 131760ttagcaaggc tagatgggtt
ttcaaagaag gggagtgtga tttaccttct agttatagag 131820ataagaggag taaaaaggcc
attactgaag gggctgcagt tgtctggggt ccgctggatg 131880agggtcataa gtacacaaag
gcagtgcgat ggttgagtcg ggtcctctgg gctttgagct 131940ccctggtctt gggctttagc
aactggtccc tccccaaaat ctagtggcac cctgttgaga 132000gttcttgtgg gggaccagtt
gggaatatgc gggtggggtg ctgtgccatt ttggaggttc 132060ttctaattct ggatagatct
tgggagaaac cgagggctgc agttcaactg ctgccagatt 132120taactttttt tttcccctct
ggatggcaga ggtccaggac tggggagcct ggattattct 132180tttgaaacaa aggctttaaa
caggatggga gaggggggat cctctgctaa ttttttctag 132240atgagaacgt agggcactca
atctagctga gaccctggtc ccctctgtaa aacaacttta 132300agagctgaaa acagatccaa
accaagggtg ccctctagtg gccaactaac atcaaagctg 132360gccattccat agagcagaaa
gttctctaaa atctatttca gccatccacc gagacaatgt 132420gagtcttagt cttaatttca
gtcctgtgca caagggtcag tccaaggggc atgctaattg 132480tcggtcccat catcaaagtt
acatagaggg gaaaaaccaa tatatacaca caaaaagatt 132540acaataacca agaccaggcc
ccaataagat ggccgagaga gcacacactc acttggcacc 132600cagtaacaga aacagacagc
cgagtgagca cacactcact tggcaccctg ataggaaatc 132660tccaggtatc cttggaactc
cctcagaact ggggagtgag ttttttctga atttttatct 132720ccttgtcctt ggcaaaggaa
ggcaggcatc tctggttgta aagtatagaa acaaaatgct 132780tttttgctgc ctatagagag
caaagagctt cttcctagct gtattttcag agatcaggga 132840aaacaagctt ggggaatgtc
taggggcttt atcttactgg gagatatact ttaagttaga 132900aactcacagt aggatatttt
ttctacaaca cacaaaactt tacacagaag attattacaa 132960ttatttataa taaatatata
atatttgatt tgaaccaaat gtcatatcca tataaaatac 133020atggtagtat tacaaaaaaa
ttgtaatatt tactttaaac aatttataca tttacacccc 133080acagcacttc ttcataactg
tactaccctt tctgagatcc ttcttcttcc caaatagtcc 133140ctctcttatt tttataatgg
ttctcctttt cttttgtgta tatatggaaa catctcatgc 133200aggtggttgt attgtactcg
ttgctatgtt tttgtgatca caaagtctaa aggaccacaa 133260tctgttcatg aactacatat
ataagagcat ctgaccctga gttgctcttt ttcctgaatc 133320tacttctcca gtcaagggat
cacaaacacc acttttgaag tactctattg aaatgggata 133380aaattgaata tattgtacca
tatcttcatc tgtttctacc tgaggtgata tattctcatc 133440tttgtcaaat gctgggctct
gtactatatg gacaacagaa aatggaaaca taatatgcta 133500tattagtaaa agggaataaa
gttttaatga tttgaatttc tcaggaaata ctgcccatgt 133560gaatttttga aatagctttg
agaaatgaca taattgaata catgatatcc ggtatagtta 133620tagattagaa gtaaggtttc
caaattatag ggccattgaa tatctttacc aatattataa 133680aaaaaaaaaa cttccctaac
ttaaagaaag ataatctcat gaatatacaa gaagcctaca 133740gaacgccaaa ttatttggac
cagaaaaaaa aaatcctgcc atcatataat agtcaaaaca 133800ccaaatgcac aaaacaaaga
aagaatatta aaaggagtaa gggtaaatgg tcaagtaata 133860tataaagcaa gatctatcag
gattacacat aacttctccc ctgagactat gaaagccaga 133920aaatctaggg cagatgtcat
acagaatgta agagagcaga aatgccagcc aagactacta 133980tatgaagcaa aactttttaa
catagcttga gactacaagg tattctgtga caaaaccata 134040tttacatagt atcttccaat
gcatccagca cttcaaacga taataaagag acaattccaa 134100tataacgagg gaaattacac
tcaagaaaaa gcaagaaatt aaacttgaag gaaacctaaa 134160agaagataga tacatgaaca
aaattccaac tctaataaca aaaataacag gaagcaacaa 134220gaacttttcc ttagtatctc
ttaatatcag tggattcagt tcaccagtaa aaaggcatag 134280aataacaaaa tggatgtgta
agcaatattc agcacaccag aaacaaacac caaggacaaa 134340gtcagacatt acctcagact
aaaagcctgg aaaaatcttt ccaagcaaat aatcccaaga 134400aataagctgg agcagccata
ctaatatcaa ataaaattca ctttcaaccc aaagttatta 134460aaaaaggcaa ggagggaaac
ttcatattca ttaaagttaa tatttaccaa gatggactcc 134520caaatctaaa catttatact
ccaaatgcaa tgacatccac atagataaaa gaaactttag 134580taagctcaaa acacacgttg
taccacacac aataatattg gaagacttca acacccctcc 134640ctcattaatg gacagatcct
gtaaactaaa actaaaaaga tacacggtga aactcacaga 134700atttatgtaa caaatacatt
tagttcatat ctatagaaca ttttatccaa aaagaaacga 134760atgtcccttc ttctcatcac
ctcacgatgc cttctccaaa attgaccaaa cactcagtca 134820caaaacatgc ctcaacagat
ataaaattat tgaaataatg tcatgcttcc tatcagatca 134880ccacagacta aggctgatct
tcaacaataa catgaataat tgaaaaccta catacacgtg 134940gaatgtgtac aacaatctag
tcagtgacaa aacagtcaag gaagaaatct agaactaaat 135000taaagacttt ttagagttta
atgaaaatgt agctacaaca tactgcatgt tatgggacac 135060aataaaaata gccctaagat
ggactctcat agctctctct gaatgcctct aaaaaaaacc 135120ggagagagga tataggagta
ggttgacaac ccaccttaac actatagaac aaaaggaagc 135180aaattcaccc aaaaggagtt
gaagtcaaga aataatcaag ctcagtgcta aaatcaacca 135240agtggaaaca aaggaacaat
acaaaaataa tcaaacaaac tgggagcttg ttctttgaga 135300aaatcaacaa gatagataaa
ccattagaca gacaaaatac agaacacaag aacagtatcc 135360aatttagcaa aaccagaaat
gaaaagggag aaataacaac agaaatttag taaatttgaa 135420atatcaaaag atccaaatac
aaggctgtac tcaacaaaac tgaaaaatct ggataaaatg 135480gacacttatc tagacagata
ccaggtacca aattcaaatc aggatcagat aaaccctgta 135540attacttcta ccactgtgaa
aagccgccct catggtcgcc attacgagat ggtgctgaca 135600acaccattgt caccattgct
catggtgagt gcacgcaggc gtcaggatat ctttccatta 135660cctgagccct gactctccca
tggcatcatc aggctgattg tgggcatcca atcccggtgg 135720tgcacgtccc caaccatact
tctaaccata cttcacagcc tatataaggg aggggttttc 135780tgctctctgg gtctcctgtc
ttgaagctgt tcatctatct ctggagatgt attaaagctt 135840tactacagaa agatctgagt
gtcctggatg cattcttgct ggcaagatgg tagcgtgggt 135900catctggtgc cagaaaccca
ggatcaacat cgctggcatt gaggagaacc cctgaagaag 135960ggatggattc agaactgcag
gaaaaaggta agttcgcaga ggtatatctg atcgtgaacc 136020tcttatccct tttgatttca
gtcttaatct agatgcaact taggaacggg cagtagaagc 136080tctagttttg gttgccctgg
cgctcattct gtttcttatt ctgtccatcg aggctggtgc 136140tgaaatttga ggtccatcgc
ggctggtgct gaaaaatgag gtgttgtcag tccaacatag 136200ataagtggca gcactgaggt
atcttctaag ccttccatag ataagggagc agagcgctgt 136260gtttactttc actttgctta
aggaatacta taagtcgggt gtagatcagc cgcaggcact 136320cattctatca tgggcttctc
acagtcagtg atcaccacat tacaggcagt gctaaagcaa 136380cgtgatctgc aggttgcctc
ccatatgctg cagaattttg ttaaggaggt ggatcgcatt 136440tctccctggt atgcctattt
ggggtcacta actgtagcct tatagaataa gctaggaagg 136500gaccttgacc ataagcatga
agagggagac ttacgcctgg gcaccaaggc aatttggaag 136560ctgataaaaa actgtctaga
ggatgaaacc tgccaaccag ccaatgtgga gggacaggga 136620atactagaag aggttcagga
cagtatgtga gaaaactaac agaatgagag aaagggagct 136680cgaaaaaaga aagacacgtc
taagaaaaag ggccctccca gggattcaga aggaagggga 136740gagagaaaag agggcagtaa
aactgatcct ctactaagaa aaagccacac atgtaattca 136800acattgcctt gaagcttgga
gtgcttgggg acaacccaaa tttcttagaa cagataatgg 136860actggcctac acctctcaat
aatttcaaca gttctggcta cagaggaatg taatttattt 136920aactggtttg ccatacaggg
acaaggcatt gtggaacatg cccaccacac tcttataacc 136980taccttatca aactaaaagg
ctgagtcgat gaggccccgc ccttaacact gagagtggcc 137040gtctccatgg tactctttac
tcttaatttt ttgaatattg atgaacaagg ccacactgca 137100cctgatcatc actgttcaga
acgaaacagt tctagagaaa tgatcaaatg gaaagatatc 137160ttaaccggaa aatggagatg
cccggatcct attttaataa gatccagggg agttatttgt 137220gtctttccac aggaagaaga
caatcctctt tgggttccag aatgcctcat ctaaaggatc 137280tccccttcag aagatgtgga
caaaagaggg aatactgaaa caaagatgga tactgaccct 137340tctactggag atcctggttc
ctagtatatc gggggaattg tgttggggta ttatgtccac 137400ctttcccctg cccatgcctg
tcatgcacag tgcacaagtg tttccacatt tctttactac 137460tgatagggag cttcaacttg
cctttttatc attagatggg caaattcaga ctctgatgga 137520aaacagaacg tttccctcaa
aagttgcata tgtagcagag gatggactag taagtcatca 137580atgggaggag agacacttgt
tcttgtaaag ttcctatgac caagttttgg gaatgcctgg 137640gtcaggaatt gggagtgggt
gtgcttgttg gagagcaggg tgagagggga gaggactggg 137700atttttggag gggaaaatag
aaaagagaat aacatttgaa atgtaaaaaa aaataataat 137760aataaaaaaa gaatgaatta
aattatttgt agtattcttg aaataaattc aagttttaca 137820aatatattat tggaacaatg
ttcaggtatt ttcctttggc agaataataa caagttattt 137880tttatcaata tattgtgact
acaatgccaa gaatagttat atgtgttgct aaaactcggg 137940tataggaata tatagatata
ggtaaaattt caaatgaatt atacaaaatc tcttagaaaa 138000gacttcttac aattcaggtg
actaggaaaa agtctagtga actgcaggac acgcaattaa 138060tacccaaacc agaatatgca
ataaccttca gaaagagact cctctgaaat atttatgtca 138120tcttcttcat catcaaagtc
caaaagtaat aagtaatctc ctttggaatc accatcattt 138180tcttaacagc cattcttctc
ttaaaaacta taatgtcttc ttagttaaaa aaaaatggaa 138240aaaaaggaaa aaaaatctta
gtaatctgaa tccaaaggta tcatttaagt agttaaaaat 138300atcaaaaatg aaataattat
atgcacttcc tctttccagt tcctccatgt atcccattta 138360tcatgtccct ctccctcaaa
acattgtttt aaaatcttat taacttactt ctttaagaaa 138420ctcctttaga accagagcta
acaatatgtc agatcccagt ttaaataagg ggaaaaaggc 138480cagccttgaa tatgtgagac
ttcttaacta cccaaagacg atgagcaaaa tgtatttgca 138540tttaatttct gagtcatctg
attcttgttc ctatttccca cagattcttt ttaaacaaaa 138600cattagcaat tttgtttatc
agtgtgtctc tgtctttaaa taaactcaca ctgctatcaa 138660gatagataat gaatatggta
actgtatatt catttgagaa gacccaaagc tccctcaaca 138720atcaacaccc aacagcacca
gcacccacac agaaagacct tctattggag aaagcaggga 138780tttggggaag acttggtttt
caaatatctg gagattgtaa gtccaaggcc agcccaaacc 138840aagacagcct gagctaaaac
gaagaaccca tcctacagaa gggaaacgga gagaaaaggc 138900tgatctccat ggtgcaagtc
tttaatagaa atacttgggg aatgagaggg aggatctgtg 138960gtaagaatcc atcttagaag
acttatgaat cttctgcatt gtctgctctc attcttttca 139020tttattcttc ctatgccact
cccctttctg tagtatccat acagtctcta ccaaagaaat 139080acacactaga gaagacagtg
agggtagagg aatcctcagt gtgtctctaa tagattttgg 139140actacacaca ggaaaagtgc
caatttcaac cctaaggcct cttacagcaa ataggacaat 139200cgccaagact cctcaccaat
ggcaccctga tcccctgacc cccagtcctg cagccggctc 139260tctgatcctc tccctaggct
tcaagcttgt gtcctacaag ggctttcaat cctctaagcc 139320cctgtcctgt tcaatcctgt
gcaatgaata tgatcctcct ccttcattta accctcagaa 139380gccataggaa atgccgatca
ggaggctttt cctcacagag tggcctcctg ggactgagat 139440ttcccaccac tcacacatct
gttaatagtc caattatcct gatcagagct ggttatcagt 139500tccaggtctt tcaaaagtga
actccttcac aaccgaaccc ttccttgctt ggctctcaat 139560gaaaaaaaca aaacaaaaaa
aaaacaaaaa aaaaaaacaa agcaaaacaa aacaaacaaa 139620caaaaaaaac taagcaaaaa
aacaaaacaa aaacaaaaac acaaagaaaa aacaaaacaa 139680aaccaaaaaa caaataaaaa
actaaacaaa taaaaaacaa aacaaaaaca aaaacaaaaa 139740caataacaaa acaaaaagaa
aaagaaaaac aaacaaaaga aaaagtaaca aacaatcaaa 139800caaacaaaca aacaaaacgt
tatcaggaga gacctagatg gtgtactctg aggacccttt 139860atgatgccag atggagaaaa
caggtctcat ccagggattt cactgtttgg ctgaatatac 139920cctgtgtatg ctgtcatgga
gtaccaggca ccattgattg gaagggagtt ctcaggaggt 139980ggaaaagagc taccatcttt
aagacaaatg atttccaatt actaggttga aaagcatttg 140040cagacttgaa aaacatgaac
aaatgtgtaa catatgaaag cactggaaat ggcactacta 140100atttcaactg taatattttt
ttttgttatt tatttatgtg cataaaatta aaatgtgtgc 140160actttttctg tatgtacata
cctacaacag aagagtccat gctgtcctaa tagatctgaa 140220aataacatcc agattcccta
caatccctga taaactccca cctccacctt cctagtactg 140280agcttgatta caagagtgtg
ctaggatgtg caggcccttt ctccctcact tatgtgctag 140340gctgcccagc ccctttttat
cccttatgtg ctagagtgct cataccctct ctctcattta 140400tgcctctatg gcctacagag
gctgaaagag agcagtgatt ctctaaaact gtggctgtgc 140460ataaattgta agccactatg
tgtgtgcatt gtgcccggtc ctcttcacag aacaggtgct 140520gtttgtttgt ttgtttgttt
gtttgtttgt tttattattt tttgagagag ggttactctg 140580tgtagacctg gctgtcctgg
aactcactct gtataccaag ctggtctcag actcacaaat 140640tattggcctc tgccacccaa
gtgatgggat taaaggcata aaccaccact gcccaaacaa 140700cagttgcttt tatcagctaa
tttttccatt tttcaactaa tctagtgtgt acttcatgta 140760tctttagggc atttctccca
tttactttca aggtggaggg tgtttccacc ggaacaggga 140820tccaaagtgg gatccgtgcc
accatggcac gggtgttctt tgttacatcc caacattgag 140880aaatccaaca agaatcattg
gaacagactt caaaagaatc acttgaaaga atataaacaa 140940gaaagggggg taaacacaga
ctgggggaga tgtataatta atctggttta ccaaagtttt 141000attgaatcca gtgatctcta
cacagatatt agtatgtcca taagagtcct gggaggcatc 141060atgtattccc caatgctgag
caaatcttga gatgccaata aaagaagcct ttacaactgc 141120tcctccctgg ataaaattca
aaggatttag ttctctacaa ctgccattga ctccacaaag 141180cacccacttg tgaaaaggat
gcattctaaa gtcctgtatg aaaaatctct ttttcataac 141240aaattccttc tctgggtcat
ctgtcatgtt gaaagaaaag gaaaaagttt tactctgatc 141300tgcccaacaa atgatggagg
atcgataatc agaccaaagc aggatcagcc cttcatcttc 141360caagatacaa tgaggggcta
tttttgtttg gtggggatgt cctttttctg aaaagttagg 141420tggtagaaat gtaccattaa
cctaaattgc ctcttgccaa aaggtccgat ttataaaggt 141480tatatctaca ttggaagtat
cttgggttgt gctcacccaa cctcctcggt gctcattaaa 141540cttccctaaa gctcgggctg
ggaggttgat acaatttctg gtccattaat ttgaaaacat 141600aaagacccct gttctagtaa
ggagtgattt tctcctaatg gtgctcgagt gggatcatag 141660gttaaatatg gcaaatccac
tgttttatta gtagtaaaga attttggaaa aactatagca 141720tcatggcgaa ctgacattgg
tttagggaaa gtcgagagaa tagcccttct ctgttcaccc 141780attatactag aaacctgaga
caagttcagc attgtcagga tcaggaacag tcctggggag 141840gtcagcatct tctgcaccat
ccttgatgaa tatcctgcgg gtgagtcgtt ccggcagcca 141900atatgggttg tcctcactct
gtggaaaaac acaaacagct ccccaggata tgattaagat 141960aggatccagg cctttccaca
gaccagttaa aacatccttc cctttgacca tttcttttgg 142020tctatcaggg tctgagttat
gtcactcagc tacagaacgt ccctgctcgt tgagattcaa 142080aaaattaagt gtgaagagtg
acatagatac tgctactctt ggcactgaga gcagagtctc 142140atcaactccc cctttttgtt
ttataagata agacttgagt gtgtggtggg cacattccac 142200aatgccttgt ccttgaggat
tataaggaag gccagtcaag tgactgacat ccatttgatg 142260acaaaattat tcaaatttag
tagaagtata tgctgcccat tatccgtttt aagaattgtg 142320ggcttgccca aagcactcca
ctcttctagg cagtgctgta taacatgaga ggctttttcc 142380cctgttaaag atgtggcaaa
cattacacca ttgcaggtat caatggaaat atgtaaatac 142440tgatttataa tggctattgc
aggtggcacg cacggctctt cttaaggatt gcttgtggca 142500cgcacgcgat tgctcgggac
atggcactac acagccgtct atataaaaat gaaaatgtaa 142560ttaaggataa aagtgataca
ggagaaatgg ggaacaattc aaggaggaga agatagggat 142620aaatttgcta aaactcattt
atgtgtatgc agaaagttct tacccaacaa atttaaaaca 142680aagtaagtaa gtaagtaagt
aagtaaataa atagaaaaat atatgtgtat gcacatgcat 142740acacgatagg catttgtgta
tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg 142800tgtgtgcata tatgggtgta
ggtatgtagc acctgttact agaggaatgc aatcatgcag 142860tatctttctt tatgttgtat
gatgcagtgt gttgattaga atatcttttg cccaagggat 142920gtggcactat tacgatcttt
aagtggcact attattatct ttaagtgctc cttagccatt 142980ttagactgtt ctgaattgac
atatctattt agatatatac cccatatttg attggtttat 143040ttcgtttctt gagttcttta
tatatttagg atattagccc tttattggat gtgaggttag 143100ttaagatttt ttctccagtc
tgtagcttga tgattagtct catcgcctat atgttttgct 143160tacagaagct ttccagtttc
atgaggtcac atttatgaac tgttgatctt agagcatgaa 143220tcacgggaga tgtttttagg
acatttccct ctctgtgtca atgagtttat cttctattag 143280attcagtgca tcttatttta
tgttgataat cgtgttcaac ttgaaactga gctttgtgca 143340aggtgatcag tatggatttt
tttgttcatt tttcaacata cagactgcaa attagaacag 143400cacaatttat tgaaaatcct
ttcttttttc catcgtatat atatccatat atattttgct 143460tctttgtcaa atatcaagtg
accataaatg tgtggttttc tttctggatc ttcagttcta 143520gtccactgat ccatctgtca
gtctctgtat caataccata tagttttgat ttgttttgtt 143580ttgttttgtt ttcttttaat
cacttttgct ctatagtaga gtttgaagtc caggattgct 143640ctgagccagg atagcagtgg
agtcacagag taggaccctg gcaatggctt taaaatcgaa 143700gtgtcccagg gctttctagc
tttcaaattg tacttaaatg ctgatgataa cttctaaaaa 143760gtaataggtc tttctgaggg
taggctggct taggtgatta acacctgtag cctaacagag 143820gaggattaac aatgcagcct
tttttctagc tcagcaggaa ttgctgggct ctaattttga 143880gcctactagc cagatgtcac
tggaagagaa ggaatttata gaagtgatta tagaagttat 143940tacttggtta taaaaatatt
ttttatgaaa gttatataag gggaaaagca gaaagatcct 144000aagtgctgaa agggaaaaat
tcttctaagt ggggaaaagg aaaaaaaaaa gtctaagtgg 144060agaaaggcaa aaaaaaaaaa
atcttctctc ttgatttttc tcgtctcttt gtcctcagca 144120cttatacata tttcagaata
catgaccaca tgttacaaag ttcatcaact gtctcagatc 144180aataggtaca ctgaaggtat
caaaccataa ctaagatatt agtgaagttt tgtataggta 144240aaaccaatcc atattttacc
ttttacccta gaacatataa taaatcgtta gttcccttct 144300gatgaccttt ggttaattgt
tatacaacct cttgtaatgt gctctgagta ggagaaagcc 144360tagttactat ctaagagcaa
ttagccagtg acacttggaa aactggcagt tctcattgca 144420gttttgacta tcagaaaaag
gacctaatag cccttttagt ttggggagaa ttttattgag 144480tatttttgca ttgatataca
aaagagaagt tggtctgaag ttgctttaat ctggaatcaa 144540ttcaccaata aaaacaaata
gactaacaga ctggatatat aaacaataca caacattttg 144600ctgcataaaa gaaacccacc
tcagggacaa aaccagatac tacctcatag taaaaggctg 144660gaaaacaatt ttccaagcaa
atggtctgaa gaaataagct ggagtagaaa ttctaatata 144720gaataaaatc aatttccaac
ccaaagttat caaaaaagac aagaagggac agttaatgct 144780catgaaatgt aaaatcttcc
aagatgaacc ctcaattctg aatatctatg ctccaaatgc 144840aatggcatcc acattcatta
aagaaacttt agtaaaactc aaatcactca ttgcactgca 144900caccataata gtgggagact
tcaacaaccc gctcttatca atagaaagat cctggaaata 144960gaaactaaac agagacacat
tgaagataac agaatttatg aaacaaatgg atttaataga 145020tatctacaga acattttacc
ctaaaacaaa aggttataac ttcctcttag cacttcatgg 145080taccttctcc acaatagacc
acaatcagtc ataaaacagg actcaacaaa aatattgaaa 145140gtatcccata caccctatca
catcaccatg gaggaaggct gatcttcaat aacaacataa 145200atagtagaaa gccaacattc
agttgaaagc tgaacaacac tctactcaat gataacttcg 145260tcaaggaaga aataaagaag
aaataaaaca ctttttagag tttaatgaaa atgaagggac 145320aatataccca aacttatggg
acacaatgaa tgtagtccca caaagaaaac caaaagctct 145380gagtgccacc aaaaagaaac
cagagagagc acacactaag agcttgacag cacacctaaa 145440agctctagaa caaaaggagg
caaatttaca agggggagta gatagcagaa aataatcaaa 145500ctcagagctg gaatcaacca
agtgggcaca aaaagaacta ttcaaagtat caatcaatac 145560aggagcctgt tctttgagaa
tagtatcaag atagatacac ccttagcaag acgaactaga 145620gggcacaggg atagtatcct
aattaacaaa atcataaatg aaaagggaga cataagacca 145680gaacctgagg aaatcctagg
catcatcaca tcctactaca aaaggctata ctaaacaaaa 145740ctggaaaact tggacaaaat
ggacaatttt ctagacagaa atcaagtacc agagttaaat 145800acagatcaga ataaagatct
aaacagcccc atatccccta aagaaataga agcagtcact 145860aatactctcc caaccaaata
atgcccagga ccacccttat gggtttagtg cagagttcga 145920tcagaccttc aaaaaagaac
taattccaac tgttctcaaa ctatttcaca aaatagaaac 145980agaacgtact ctattcaatt
cattctatag aagccaaaat ttctctgata actaaaccat 146040ataaagtccc aacaaaatag
aggacttcag atcaatttcc cttatgaata ttgatgcaaa 146100aatattcaat aaagtccatg
caaactgaat ctaagaacat atcacaaaga tc 146152398755DNAHomo sapiens
3ccgaacccga acccgaaccc gaacccgaac ccgaacccga acccgaaccc taaccctaac
60cctaacccta accctaaccc taaccctaac cctaacccta accctaaccc taccctaacc
120ctaaccctaa ccctaaccct aaccctaacc ctaaccctaa ccctaaccct aaccctaacc
180accctaaccc taaccctaac cctaacccta accctaaccc taacccttaa ccctaaccct
240aaccctaacc ctaaccctaa ccctaaccct aaccctaacc ctaaccctaa cccaacccca
300accccaaccc caaccccaac cccaacccta acccaaccct aaccctaacc ctaaccctaa
360ccctaaccct aaccctaacc ctaaccctaa ccctaacccc aaccccaacc ctaaccctaa
420aaccctaacc ctaaccctaa ccctgaccct aacccctaac ccctaaccct gaccctgacc
480ctgaccctga ccctgaccct gaccctaacc ctaacccaac cctaacccta accctaaccc
540taaccctaac cctaccctac ccctgaccct gaccctgacc ctgaccctga ccctaacccc
600taaccctaac cctcaccctc accctcaccc tcaccctcac cctcacccta accctaaccc
660taaccccaac cctcattatt ctcggctgca aagaggaagg atctttaccg tggatgtggc
720ccccagttgt cccaaaatga agcagtgccc ccaacgtctg tggagaggca tgcgctgctc
780caccttcgcg atgtcccccg cgtctgtgct gagcagaatg cagctccgtc atcgcgttcc
840ccccgaagtc tctgcagagg aaaacggagc tcctccttcg cgatgctctc caggtctgcg
900ctgaggggaa cgcagctccg ccctcgcaaa ggcatagagc catcgcaggc gcagaaaaaa
960acgtcggtgc agcgcaggcg cagagaaaaa cgacggcgcg tccctggggg gcgcggcgca
1020ggccgagaga ggcatgccac cgtggcgccg gggcgtgggg cgcggcgcag acgcagagac
1080gcacgccggc gcggcgccgg gatgggagcg cggcccaggc gcagacacgg acggcagcgt
1140ggcgcctggc ccgaggcgcg acgcaggccc agagacacac ggcggcgcgg cgccatgatg
1200gggccccgcg caggcgcaga gacggatggt ggcgcggcgc aggcgcagag aaaaacgcca
1260gcgcggggcg gggggcgtgg cgcaggcaca ggcgcagaga cggaggcggg cgcggcgcag
1320gcgcagagac ggaggcgggc gcggcgcagg cgcagagacg gacgccgccg cggcgcaggc
1380gcagagacgg acgccgccgc ggcgcaggcg cagagacgga cgccgccgcg gcgcaggcgc
1440agagacggac gccgccgcgg cgcaggcgca gagacggacg ccgccgccgc gcaggcgcag
1500agacggacgc cgccgcggcg caggcgcaga gacggacgcc gccgcggcgc cgtggcgggg
1560gcaagagtca cgcggagaga tgcacggctg cgtggcgcag gcgcagagaa aaacgccggc
1620gcgtccccga tgggcgcggc ggaggcccag agacgcacgc cggcgcggcg ccggggcggg
1680ggtcggggcg caggcgcaga gaaaaacgcc ggcgcggcgc cggagcgggg gcgcggcgca
1740ggcgcagaga cccacgccgg ggcgggggcg cggcgcaggc gcagagacgc acgccggggc
1800gggggcgcgg cgcaggccca gagacgcacg ccggcgcggc accggggcgg gagctccgcg
1860caggggcaga aaaggacgct ggcgcggcgc agacgcagaa aaaaaatggc ggcgcagcgc
1920aggcgccgag aaaagcgcca gcgccggggg tcgcggcgca ggcgcagaga aaaacgccag
1980cgcggcgccg gcgcaaagac gggcgcaggc gcagagtcgg gcgctggcgc gtcgccgagg
2040tgggggcgcg atgcacgcgc agagacgcac ggctgcgtgg cgcagacgca gagaagaacg
2100cgagcgcggc gccgaggaca aggcgcaggc gcggagacgc acgccagcgc gggggcgagg
2160cgcaggcgcg gagatgcact ccgccaggcg cggggagggg ggcgcggcgc aggcgcagtg
2220acgcacgccg cctggggcgc agcgcagaga taggcggaac ctcagtaatc tgaaaagcca
2280ggttgccccc tccttgcggc cgggcactaa agggcccact tgctgaaggc gctgtgccag
2340cgtgccccct gctggtgact ggggcaactg cagggttctc ttgcttccat tagtggccag
2400cggcccctgc tggctgcggg gcaccgcagg gtcctcttgc acacagtata gtggcggcat
2460gccgcctgct ggcagctggc gacattgcag ggccctcttg ctcatagtat agtgacagga
2520cgcccgcctg ctggcagctg gggacactgc cggccactct tgctccaagt gtagtggctg
2580ttggctcccc tgctggcagc tggggacact gccgggccct cttgcttgca gtttactggg
2640ggcacgcccc cttctggccg cttggggcac tacaggatgc tcttgctcac agtgtagtgg
2700cagctcgccg cctgctggca accagggtac tgcagggttc tcttgctcat ggtgtggtgc
2760ccgtccacca cctgctggca gctaaggaca ctgcagggcc ctcttgctca gagtgtagtc
2820gtcgtacacc ccctgctggc agctggggat gctgccggga cttttgctgg cactgtcgtg
2880gcagcacact acctgcaggc cgatggggac tatgcaggga cctcttgttc agggtgtgag
2940ggctggcacg ccctactggc cgcctcctgc accacttaaa gtcggagcgc cagttgttaa
3000gcaccatcag ttctggaaat tgaaactgaa atggagctat tactgaggag agttgatgtc
3060ccagttcttg tctaacttgg aagaaagatt tttcaccaag aggcagtaaa aacatggcag
3120ataacttcat tgaaaacaaa tacagtgtaa agagcttatt gtagaataat agggaggagt
3180gggctgattg tgcaggaaaa cagcctgaga gtcctgtgca gggaatttta ttttggactt
3240cttcacattt ctgcctctgt ctcaagtctc cacctgtttt ctttgtctgg ttttcctgct
3300actgccttag gtccctgagt tgccccactt aggcttatgg gacctcctca ctgttggttg
3360aggcacatgt gtggtgatca atccgaatcc actctggtac caggctcctt ccccccatcc
3420caggcaggct gacagcggtc atgtttctgc ctacagcgcc tgcctatctc ttttgaatgt
3480ccttctctac cctactctgt acttatggtg ccaggtttct cttaagaatg tcccctttgt
3540ccttcttatc agcatgtagc cagcaatatt gtgacatttt tactgcagag tgaatgatga
3600ctggggcatc ttaaatggag ttctggggtg tttctttctg cataggtacc tctgcagtag
3660tagtttccaa aatacttttg gtaattttta accttaaagt taaccttaaa gttaagctaa
3720gtaaaagatt tgcattaaat atctagacca tttataaata agatacaata ctaaaacatt
3780actgaagata aataattcaa gtttacatac ttttggctac ttatttttac agagaaacta
3840aagatatttt agcccattaa taaacatgtt tttgtctacc acactgagaa attgtactat
3900gaggaaacac atccctctag atgttgggag atggtatact catacatttt ctaacctact
3960atagaatgct aacatatgac agtttataac tgtctacttc ctagttttct ctggaaaata
4020aaagattact aagtattaaa attataatca atatgtgtaa ataaaactac tggaaataat
4080agaataacta gaaacaactc tatgcaaagc atgcaagaaa agtagtgcat gttttgcaag
4140taaagtagga cgtatttttt ataaggaaaa ccatacaaaa gatacaaata aaaagagata
4200cctagccttc cctgtgttat atttgtatgg gtaaaatgtc atgttttcag aaattatata
4260aaattcctgg aaatttgtca atgttctcct tatccatgct atgtgccagt atagagttat
4320gagtcataat tccaattatt attttaaatg ttgtgctggg tgcagtggct cacgtctgta
4380atcccagcac tttgggaggc ctaggcaggt ggatcacaag gtcaggagat cgagaacatc
4440ctggctgaca tggtgaaacc ccatctctac taaaaataca aaaaattagc caggcgtggt
4500ggtgggcacc tgtactccca gctactcagg aggctgaggc agaagaatgg catgaaccag
4560ggaggcagag cttgcagtga gccaagatag cgccactgca ctccagcatg ggcaacagag
4620cgagactctg tctctaaata aataaataaa taaataaatg ttgtatccca cagaaaaaat
4680cgaatatcct tgtcagttgt ggtataatga actctcatca gatctttcat cacagccatt
4740tcatattctt tatcatttag atattatttc cccctgatgc tttcctgaaa gctcctgcaa
4800tcagctacag gtcagaatgt tcatctccat cacgggattc cctctgagac acacagaaaa
4860gagtatgcaa gatagtctgg ttataggctt ctgatgatat tgtttaaata actttaagac
4920catacacttc gctcagtgaa gatctccaga agtctgcttc agaaattgat gggttcatga
4980cactgctaac ccaagatgca acaagactgg aattgattac atggtactga atgaactgat
5040gaaaattgat tataatttta tagctttttg gagcattgct ggttctttaa tgttctagtt
5100tctggactta agaaatctct ttctcttaac ctaactgtaa catacaattt agtagattat
5160acttttgaaa acagaagtga agcatttatc ttttttcccc tgcctgattt ttccagaatt
5220ttgaaatcct tactgaacac tcttattttc acgatgatat agttgttagc aaaagtccaa
5280taagaatctg ttcaccttga acagagacct cagaaataat gccgcatatc tacaaccatc
5340tgatctttga caaacctgac aaaaacaagc aatggggaaa ggattcccta tttaataaat
5400ggtgctggga aaactggcta gccatatgta gaaagctgaa actggatccc ttccttacac
5460attatacaaa aattaattca agatggatta aagacttaca tgttagacct aaaaccataa
5520aagccctaga agaaaaccta ggcaatacca ttcaggacat aggcatgggc agggacttca
5580tgtttaaaac accaaaaaca atggcaacaa aagccaaaat gcacaaatgg gatctaatta
5640aactaaagag cttctgcaca gcaaaaaaaa acctactgtc agagtgaaca ggcaacctac
5700aaaatgggag aaaattttca caacctactc atctgacaaa gggctaatat ccagaatcta
5760caatgaacac aaagaaattt acaagaaaaa aacaaacaac cccatcaaaa agtgggcgaa
5820ggatgtgaac agacacttct caaaagaaga catttatgca gccaaaagac atgtgaaaga
5880atgctcatca tcactggcca tcagagaaat gcaaatcaaa atcacaatga gacaccatct
5940cacaccagtg agaatggcga tcattaaaaa gtcaggaaac aacaggtgct ggagaggatg
6000tggagaaata ggaacacttt tacactgttg gtgggactgt aaactagttc aaccattgta
6060gaagatggtg tggcgattcc tcagggatct agaactagaa ataccatttg acccagccat
6120cccattactt ggtatatacc caaaggagta taaatcatgc tgctataaag acacatgcac
6180acgtatgttt attgcggcac tattcacaat agcaaagact tggaaccaac ccaaatgtcc
6240aacaatgata gactggatta agaaaatgtg gcacatatac accatggaat actatgcagc
6300cataaaaaat gaagagttca tgtcctttgt agggacatgg atgaagctgg aaaccatcat
6360tctcagcaaa ctatcacaag gacaaaaaaa ccaaacactg catgttctca ctcataggtg
6420ggaattgaac aatgagaata catggacatg ggaaggggaa catcacactc cagggactgt
6480tgtggggtgg ggggggaggg gggagggata gcattaggag atatacctaa tgctaaatga
6540cgagttaatg ggtacagcac accaacatgg cacatgtgca catgtataca tatgtaacaa
6600acctgcacat tgtgcacatg taccctaaaa cttaaactat aataataata aaataaaata
6660aatttaccaa aataataata ccaataccaa tgtgctctag ttttgtcaga tcatgaatgc
6720atcatgcatc ccaataaaag attattgaac ataaaaaaaa tctgtttacc ttataacagg
6780acataattgg aaatttttgt tatattatca aggtttttac tggaatatca tatttaggaa
6840atgtacctaa gatcacttat gaccagcaat tttaaggaag taaggttgac ttttatgcag
6900acagtgctta caaagcactc tgagaaatga gaaaattctt cttcaaaaat tataaaaagt
6960cacaatttct tactatgaga ttgctatcca ctatttatat gtgtgtgtgt gtgtgtgtgt
7020gtgtgtgtgt gtgtcttcca agtcagttgt cctagcttgc tccagcatgc ctggacagaa
7080ctagacaagc cccagcccat agtgcatgcc attccttatt tggagatgct tccttaacta
7140tccctgggca acttcctgtt ctttctttgt tctattcccc ttacctaatt aataaagttt
7200taaactaata gccaactggg taaagtgtaa aatgtgaggt cttattccag ccaatggaaa
7260ctgcacacag cagtagggta gacacataag gttataagta actctgtctc ctttgttcgg
7320tgtgttcttc tggctggaca gctattgagt agcacccttt ctgcagaaag taaagctcac
7380cttgctaaga gatcatttgt tcccatgtta attctttttt ttttttcctt ttttggaaca
7440tcaaaaactt cattcccaac agcactctga gaaaagccag cctgatacct agattacagg
7500gttcacagcc ttacaggtta gtaaggaagg tcatttcctg gtaggcccag gaatttaggg
7560atattttggg ggcctcaaga agagaggaat tcacacaaag ctataaggac tgcagctgaa
7620atttgatagt atgttcttag cttggctttt agcctgaata aggcctttaa aagtcaaatc
7680tgagattcta tatgaaaact tccagcaaag aaacttgaaa gcacctatgt ggtcatcgcc
7740tgttcttgct gcaattacat aaataatcaa gcaaaatcta ataaaacaag acttattttt
7800aaaacaagaa tagtcttact ttgattatga taaaaaatga tggttactac caagagaaat
7860tttatatttc aaaggaaaac tataacatgg ccgggcatgg tggcacatgc ctataattcc
7920agcactttgg gaggccagga gttcaagacc agcctgggca acatggtaaa accctgtttc
7980taccaaaaat acaaaaatta gttgggtatg atggcatgtg cctgtagtcc cagctaatca
8040ggaagctgag gagggaagat cgtttgcacc caggaggtag aggttgcagt gagctgagat
8100tgcacctttg cactccagcc tgggtgacag agccagaccc tgtctcaaaa aaaatgtttt
8160taaaggaaaa ctacagcctt tgtgggttat cagattctag tcttgtttct tgtttctggg
8220ctgtttttac ctctttgtaa actagatcct gccatctgat gaattctgtc ccacaatgat
8280acttggggag caagaagcca attattgtct ctcctactaa tgtatctatt gtcagttaat
8340ttgatggtca ccaaccctgg aacaaagtta gaagaggaag gttttgctcc ccaaaatgca
8400taaccaaatt gtggtacatt catgcaatgg aatgctactt agccatagaa aggaacaagc
8460tatcaactca cacaaagaca tgagcgactc ttgcatgcac attgctaagt ggaagaagac
8520agtgtgagga gcatacacac agtgtgacct catttaatga gacactggag aaggcaaact
8580acacagatgg gaagccattg gctccatggg gtgggggtta gaagcattcc atattatact
8640tattagtggg atacctgcca caatgcattt gtcaaaatat gcagaatttt acagccaaat
8700ggttaaagaa aactctattc aaattaaata aaattactca ggatgtggag tatctcagga
8760cagaatacat catgtgaaaa agaatttaac tatgctacaa attactatct tttggatgtg
8820gcttgtcccc gcaaaaactc atattgaaat ttgaccccca ctgtgtcagt gtggggcgat
8880ggggcctagg ggaagatgtt tgggtcatgg tgatggatct ctcatgaata gattaatgta
8940ctccgatggg ggtgaatgag ttctgctctc acaggaatgg attaattcct gcaggagtag
9000gtagttaaaa agagtctggc ttccttggct tccctcttgc tttcactttt gctatgtgat
9060ctctggtgca ccccttgctc cccttccact ttccaccatg aggtgaaaaa gactgaagcc
9120ccccagatgc aagtgcccaa tctcagacat tccagccaca aatattgtgg gccaaatgaa
9180ccttttttac ttataaatta cccagcctca ggtattctgt tacagaagca cgaaatggac
9240taagacacaa atggaggtaa aaactcactg aaggtgtagg gaaaatgatg ttgacctaag
9300tcactttgaa aatgaataga atctgtaggc cgaaggcaaa tgaactatac ttcatcattg
9360gattccattt tataaagttc tttccagcag aagcaattgt taacagttgt aaaaccacag
9420tatctgtatc tggaataaaa caatgactta cataagttgc agatggtagg aaccagatct
9480ctcactggtg aagtgggagg ttacaaatta gcaaggtgag aaggctagaa tgattcatgt
9540gatagtagat cagaggtgga gacatcaacg ttataggaaa agaaagagag atcagactgt
9600tactgtgtcc atgtagaaag ggaagacata agaaattcca ttttgatctg taccttgaaa
9660aatttctttg ctgagatgct gttaatttgt aactttgccc cagccacttt gccccaactt
9720tgagctcaca aaaacatgtg ttatatggaa tcaaggttta agggatctag ggctgtgcag
9780gatgtgcctt gttaacaaaa tatttacaag cagtatgctt ggtaaaactc attgccattc
9840tctagtctca ataaaccagg ggcacaatgc actgcaaaaa gccacaggga cctctgccct
9900ggaaagccgg gtattgtcca aggtttgtcc ccatgtgata gtctgaaatg tggcctcatg
9960ggataagaaa gacttgacca tcccccagcc tgacacccat aaagggtctg tgctgaggtg
10020gattagtaaa agaggaaagc ctcttgcagt tgagatagag gaaggccacc atttcctgcc
10080tgcccctggg aacttgatgt ctcggtataa aacccgattg tacacctgtt caattctgag
10140ataggaggaa aaccacccta tggtgggagg tgagacatgt tggcagcaat gctgtctagt
10200tattctttac tccactgaaa tgtttgggtg gacagtaaca taaatctggc ctacatgcac
10260atccaggcat agtacctacc cttgaactta attatgacat agattctttt gctcacatgt
10320ttttttgctg acctcctcct tattatcacc ctgctctcct acagcattcc tcttgctgag
10380ataatgaaaa taataatcaa taaaaactga gggaactcag agaccggtgc tggtgcatgt
10440ccttggtatg ctgagagcca gtcccctggc cccacttttc tttctctata ctttgtctct
10500gagtcttatt ttttttctca gtctctcatc ccatctgacg agatataccc acaggtgtgg
10560aggagcaggc caccccttca tctgccaccc aatgtgggtg cctttctcta ggatgaaggt
10620atgctaagaa tgtgagcatt gaggacagtc gagagattcc tgagtacatc caccatcagc
10680cttgcggtaa gcttgtgcgc tcagagaaac ccagggtaac aatggggcaa actgaaagta
10740aatatgcctc ttatctcagc ttcatcaaaa ttctcttaag aagaggggga gttaaagctt
10800ctacagaaaa tctaattaca ctatttcaaa caatagaacg attctgccca tggtttccag
10860aacagggaac tttagattta aaagactggg aaaaattggc aaagaattaa gcaagtaggg
10920aaggtaaaac catcccactt acagtatgga atgattgggc cattattttt tatttattta
10980tttatttatt tatttattta tttatttatt tattttgaga cagagtctcg ctctgtcgcc
11040caggctggag tgtagtggcg cgatctcagc tcactgcaag ctctgcctcc tgggctcacg
11100ccattctcct gcctcagcct cccgagtagc tgggactaca ggcgcccgct gcgatgctgg
11160gccattgtta aagcaacttt agaatggttt caagtagaag aagacagcat ttcagtttct
11220gctgcctctg aaagctgtgt aatagattgt gaagaggcgg ggacaaaatc taggaaatga
11280atggaaagtt catattgtaa atatgtagca gagccggtaa tggctcggtc aatgcaaaat
11340gttgactaca atcaattaca ggaggtaata tatcctgaaa cattaaaatt aaaaggaaaa
11400agtccagaac catcggggcc attggggcta aaagcatgat ggccacctcc tcctcagccc
11460agtgacttct gggggaggga gcctgaaact aggcttgctg cgacttggct cgaggcactc
11520attattgtcc aacctacagt tcactgtggt gaaggagcaa ttcagactca ccctgcagct
11580tcctgtatag gtcaaacagt ggccgctccc taaggaaaag ttgggggtgc tacataaaat
11640agttaaaaag ctattttata aaggacatgt ttcacccact ttctgtcttt agaattctcc
11700tgtttttgta attcagaaaa aatcaggcag atggcgcatg ctaactgact taagagccat
11760taatgcagta attcaaccta tgaggcctct ccaacccgtg ttgccctctc cagccacgat
11820ctcctttaat tataattgat ctgaaggatt gcttttttac catttctctg gcaaaacagg
11880attttgaaaa atttgctttt actataccag ccataaataa taaagaacca gccaccagat
11940ttcagtggaa agtgttgcct cagggaatgc ttaatagtcc aattatttgt cagacttttg
12000tagctcaagt tcttcaacca gttagagaca agttttcaga ctgttatgtc attcattatg
12060ttgatatttt gtgtgctgca gaaacaagag gcaaattaat tgactgttac acatttctgc
12120agaggttgca aacgcagatt cagacctcta ctccttttca ttatttggga atgcaagtag
12180aggaaagaaa aattaaacca caacaaatag aaataagaaa agacacatta agaacattaa
12240atgactttca aaaattgcta ggagatatta attggattcg gccaactcta ggcatcccta
12300cttatgccat gtcgaatttg ttctctatct tgagagggta tccagacttg aatagtaaaa
12360gaacattaac tccagaggca gctaaggaaa ttgaattagt tgaagaaaaa attccgtcag
12420cacaagtaaa tagaatagat cacttagccc cactccaact tttgattttt gctactgtac
12480attctccaac aggcattatt gttcaaaata cagatcttgt ggagtggtca ttctttcctc
12540acagtacaat taagactttt acattgtact tagatcaaat ggctacatta attggtcagg
12600gaagactacg aatagtaaaa ttgtgtggaa gtgacccaga taaaatcatt gttcctttaa
12660acaaggaaca ggttagacaa gcctttatca attctgctgc atggcagatt ggtcttgctg
12720cttttgtggg aattgttgat catcattacc caagaacaaa aatcttccag ttttcaaaat
12780tgactacttg gattttacct aaaattacca gacataaacc tttagaaaat gctctgatgg
12840tgtttactga tggttccagc aatggaaaaa tggcttaccc caggccaaaa gaatgaatca
12900ttgaaactca atatcactca gctcaaagag cagaattggt tgctgttatt tcagtgttac
12960aagattttaa tcagcctatt aacattgttt cagattctgc atatgtagta caggctacaa
13020aggatgttga gacagcccta atcaaatgta gtatggatga tcagttgaat cagctgttta
13080attttttaca ataaactgta agaaaaagaa atttcccatt ttatattact catattcaag
13140cacatactaa tttaccaggg ccttaactaa gggaaatgaa caagctgact tgctagtatc
13200atctgccttc atggaagcac aagaacgtca tgctctgact catgtaaatg caacaggatt
13260aaaaaataaa tttgatatca catggaaaca ggcaaaaaat attgtacaac attgtactga
13320gtgtcaagtc ctacacctgc ccactcagga ggcaggactt aatcccagag gtttatgtcc
13380taatgcatta tggcaaatgg atgtcacaca tgtaccttca tttggaaaat tgtcatttgt
13440ccatgtgatg gttgatactt gttcacattt catatgggca acctgctaga cagaaaatgt
13500acttcccatg ttaaaagaca tttattatct tgttttgctg tcatgggagt tccagaaaaa
13560attaaaacag ataatggacc aggctactat agtaaagcat tccaaaaatt cttaaatcag
13620tggaaaatta cacatacaac aggaatccct tataattccc aaggacaggc cataattgaa
13680agaaataata ggacactcaa agctcaattt gttaaacaaa aaaggaaaaa gagagtaagg
13740agtataacac tccccagatg caacttaatc tagcactcta tactttaatt tttttaaaca
13800tttatagaaa taagaccact acttctgcag aacaacattt tactggtaaa aagaacagcc
13860cacatgaggg aaaactgatt tggtggaaag atcaaaaata agacatgaga aataggtaag
13920gtgataacat gtgggagagg ttttgcttgt gtttcaccag gagaaaatca gcttcctgtt
13980tggataccca ctagacattt gaaattctac aatgaaccca tcagagatgc aaagaaaagt
14040gcctccgtgg agatggaaaa cccgcaatgg agcaccatcg actcgccagg tgaacaaaat
14100ggtgatatca gaagaacaga tgaagttgcc atccaccaag aaagtggagc tgctgacctg
14160ggcccagcta aagaagctga cacagttagc tgaaaaaaag cctgaagaat acaaggttaa
14220cacaaactcc agagaatatg ctgcttgcag ctttaatgat tgtaccaacg gtggtaagtc
14280tccctatgtc tgcaggagca gctgcagcta attatactta cttggcctat gtgcctttcc
14340cacccttaat tcggacagtc acttggatag ataatcctat tgaagtatat gttaataata
14400gtgcatgggt accaggcccc acagatgacc gtggccctgc ccaacctgaa gaagaaggaa
14460tgatgataaa catttccatt gggtatcatt atcctcctat ttgcctgggg aaagcaccag
14520gatgcttaat acctacaacc caaaattggt tggtagaagt acctactgtc agtgccatca
14580gcagatttac ttatcacatg gtaagtggaa tgtcactcag gccacagata aataatttac
14640aggatttttc ttatcaaaga tcattacaat ctaggcctaa ggggaagcct tgccccaagg
14700aaattcccaa agaatcaaaa agcccagaag tcctagtttg ggaagaatgt gtggctgata
14760ctgcagtggt actacaaaac aatgaatttg gaactattat aaactgggct ccttgaggcc
14820aattatatca tagttgtgca ggccagactc aaccatgttg acaggtccca tccatctggc
14880ccattaatct ggcctatgaa aggctggacc aggtttatag taggttagaa tcactctatc
14940catggaaatg gggtgtgtaa aaccccctta tatgctagtt gtaggaaaca gagttattaa
15000accagattcc caaactataa cctgtgaaaa ttgtagattg tttacttgca ttgattcaac
15060tttggattgg caacactgta ttctgctagt gagggcaaga gagggcgtgg ggatccctgt
15120gtccatggac caacagtggg agggttcccc atccatccat attttaacag aagtattaaa
15180aggagttcta actagatcca aaagattcat ttttactttg attgcagtga ttatgggtct
15240tatcacagct actgctgcgg ctgctggaat tgctttacac tcctctgttc aaactgcaga
15300atatgtgaat aattggcaaa agaattcctc aaaattgtgg aattctcata cccaaataga
15360tcaaaaattg gcaaaccaaa ttaatgatct tagacaaact gtaatttgga ttggagatag
15420gctcatgagc ttggaatacc tttttcagtt acagtgtgac tggaatacat cagatttttg
15480tattacacct cgagcttata atgaatctga acatcactag gacatggtga gatgccatct
15540acaaggaaga gaagataatc ttaccttaga gatttcaaaa ttaaaagaac aaatttttga
15600ggcatcaaaa gcccagttaa atctggtacc agaaactgag gcaatcatga aagctgttga
15660tagcctcaca aatcttaacc ctgccacttg ggttgaaaac attggaagtt ccaccattga
15720aatttttgta ttaatccttg tatgtccgtt ctctctgttg ttagtctaca ggtgtatcca
15780gcagctctgg agagacagtg accagtgaga atggaccatg atgaccatgg cagttttgtc
15840aaaaagaaaa gggggatatg tagggaaaag agagatcaga ctgttactgt gtctatgtag
15900aaagggaaga cataagaaat tccattttga tctgtacctt gaaaaattgt tttgctgaga
15960tgctgttaat ttgtaacttt gccccagcca ctttgcccca actttgagct cacaaaaaca
16020tgtgttatat ggaatcaagg tttaagagat ctagggctgg gcaggatgtg ccttgctaac
16080aaaatattta caagcagtat gcttggtaaa actcattgcc attctctagt ctcaataaac
16140caggggcaca atgcactgca aaaagccaca gggacctctg ccctggaaag ccgggtattg
16200tccaaggttt gtccccatgt gatagtctga aatgtggcca catgggatga gaaagaccgg
16260actgtccccc agcctgacac ctgtaaaggg tctgtgctga ggtggattag taaaagagga
16320aagccacttg cagttgagat agaggaaggc cactgtttcc tgcctgcccc tgggaactta
16380atgtctcggt ataaaacccg attgtacata tgttcaattc tgagatagga ggaaaactgc
16440cctatggtgg gaggcgagac atgttggcag caatgctgcc tcgttattct ttactccact
16500gagatgtttg ggtgggaaga aacataaatc tggcccacgt gtacatccag gcatagtacc
16560tccccttgaa cttaattatg atatagattc ttttgctcac gtgttttttt gctgaccttc
16620tccttattat caccctgctc tcctactgca ttcctcttgc tgagataatg aaaataataa
16680tcaataaaaa ctgagggaac tcagagaccg gtgctggtgc aggtccttgg tatgctgagt
16740gcaggtcccc tgggcccact attctttctc tatagtttgt cttgtatctt atttcttttc
16800tcagtctctc atcccacctg atgagatata cccacagatg tggagggcca ggccacccct
16860tcaaacataa acttatgttt agtttaatat agatacacac agttctacat agaaaacttt
16920ataatcaggt gtgtataggt aggttagaca cacacatata cttcctagca ttgctaatga
16980gggacaagat acaatgtgct aattcaacag ccagatgtaa gttttcctac cattctgaaa
17040ggaatcaggc tctttgaaga aatgtctgat actagaactg ggacagtaaa tataggagcc
17100aggataatct tgaagtatca gaaagtaagt actaaaaaaa attaaaatat atcaaagaaa
17160aataagagcc aataataaca gctaccgaag gccaacacag gaatgaattg tgcaacacaa
17220tgctgcagtg ttgaataata actgaagctt aaagtaatta tctaggtgtc tgtatttgta
17280tacataggtg aataagctaa tggagttgca tagaaatctc ctttgcaaaa gaattccaaa
17340taattgatgt agacactcag ccatcaggaa ggtggagcca actcctcact ccatgagtgt
17400gggctctgca tagtgacttg ctccaaaaga acacatgcag tatggacaag gaggaaaaat
17460aacttcacag tggagaaacc tgacaaacag tagctctgcc aaatgatcca agtgaacatc
17520aaaaatgaca gtttaccttg agaacatgaa gtgaaaatgg gggacattct acaaaattcc
17580tgaccaatcc tcctcagtac tgtcaaggtc atcatgagat ggaaagcctg acacactgtc
17640acagccagga agagcctatg tgatgactac atgtcgtgcg ggatcctgga tgggatcctg
17700ggtcagagta agacagacct aagggagtcc aaatgaaatg tgaactttag ttaataatag
17760tctatcagta ttggttcatt aactgtgaca aattatgtaa gatattaata agccatgtga
17820gacacactga tagaagatgt taatgagagg aaactaggtt gtggctacat gggaaatctc
17880tgcttttttt tttttttttt ggtaatttct gtgtaagtaa aaaaaaaaga tgtaaaataa
17940aactttattt aaaacctttt tatatttttt aatgcttcct tgcttaatta tttataccgt
18000gaattactag taattgacac tgttaactag tcctgttttt ttaaataaga gcatttatga
18060cacaaaaaat taaacagtgc agactgatat ataaatcaaa acaaacgctc tgtatatgtt
18120ttctgttaca gtagtaacac atatgtgtaa acttaattat cgtatttttg tcttgtgcta
18180tggttgtgtc ctggttcatt ctctaaaatg ctgatcacct tagaccagga aaaaaaataa
18240acttacagga tctgtttcaa ttcatggcta aatattttca aaagagtgac tgtaaaaata
18300tgttccaatg gcaaattgat tcattgtgat gggatcactt attctaaaga cttcttgtct
18360ttactttgtt cccatgccta ccttttagcc ataatacaac agaatcaaat attggccatt
18420gggaaaaaat attcaaagaa agaaagaatg tgaacagaac ttacaaccat gatgattcaa
18480tgttttacca caatgctttc taaaaataag agtgtaaaag gatattcaaa gtcaatttcc
18540tcagcgaggc tttgcagaaa atgaggaaac taaagaaaca aaaatggcag gacgttctac
18600gggtgatttt agatgttgct atgttttatg ggaaaaaaat actttacctt ttaaagaatc
18660actaagaatt attggaaacc caaactctgg aatgtttgca aatttagttg agcttctgtg
18720taattatgtc tatgtagcta ggcatgaagt tgatgatttt ttaaaaatct ttgccttatt
18780tgtgtaataa aatacacaat aaataattaa tgctcatagg aaaacatgtt agaccttgtg
18840aagggaaaat aaatcttggg gacccaaaat cgctaagcta aagggaaaag tcaagctggg
18900aactgcttag ggcaaatctg cctcccattc tatccaaagt cacccatctg ctcaccgaga
18960caaatgcata tctgattgcc tcatttggag agggtaatca gcaaagcaaa agaatgaaac
19020catttgtctc ttacctactt atgacctgga agccccctgt ctggccttct cacctttctg
19080gactgaacca atgtacatct tgcacatatt gattgatgtc tcatgtctcc ctaaagtgta
19140taaaaccaag ctgtgcctcg accaccttgg gcccatgttg tcaggacttc ctgaggaggc
19200atcatggggg cgcatcctca aacttggcaa gtaaactttc taaaaaatcc gagagctgtt
19260tcagattttc agggttcata catgtaatat agtatgtcaa tgtttataaa acagacatta
19320ttctgtctac tattacaact atgctgccaa ttaaccttag actttctcaa caaaataaaa
19380aatgatgagg taccaacaat atatttaaac ttaaataatg ttgcaagttt taatatgcct
19440acttttcaat ttttcaatac tatttttact actttaacac tgtaagaaaa atgagcaact
19500aaaacatgaa taaaagtgtt tacagggggt gcacatgttt cctccagcct ctgcccatcc
19560ccagctttca tcccaactct tctgatggtg gctctaagca tttcccctgt ctctatacca
19620agatctctcc ccagaaacaa gcccaaatct taccatatgt tatggcacgc tatggtgatg
19680agaagcgatg agcagccgaa gcctcaagga aaggatgctt ttgtaaaaca agacttgtag
19740aataaaacat gtgaaagtaa agcccatggc agagctccct cctcagcaca tggggagcag
19800acaggaagct tttgcctcac cttcctcaat ggccagcagc cacgtctgcc caggtcagtc
19860ttaaggacaa tgaaactctg gtcttcactg tagacatgct acactaccag gtgctccaaa
19920gccatggtga cccaccctcg ggtgggtcct gaggagaaca aagctctggt tctaatccta
19980accctaaccc tgtcccaaga ctttgaccct gaacctaaac actgatccct accctgggcc
20040ccaattctca cccttacttt gaccctgatt ttgatcttga ccctgacctt gaccccacct
20100ctaaccatat ttctggccct gactctgacc cagatcctaa tcctaaccct aaccctaacc
20160ctattattat ctttacgatc tatctctaat cttaccctct agtgctaaat agctgtatcc
20220aacagcactt ttaaactgtt taacttcttt tccttgaatt ctctaaggat atcctaaagg
20280agatgtcatt atgtattttg cattccctct gagtggtatg gcttcagata tgcagttcta
20340atactttgca agacataaaa agtttggagg gaaatagcac cgggttgtta gggatgcatg
20400tttgcattca tgatagtcat tggtgctgtt ctccaaatat tttcagttca tttgtttgtg
20460aatgcattct gactgttcca tcccacctac ttaaattttc ccatggccac atgacttttt
20520tgtttgtttg tttgtttttt gccaacggag gtgagaagaa ataacatgtg actttttcag
20580aagaaatctc caagaaacag agttctattc cgcatgcttt tttctttttt ctatagcaat
20640ggggatctta ttgatggtcc ctccttccgt ctggattcct gtgttaggat gacacagcac
20700agagctacct cacatctgac ccatgatgag atgtaaataa atgaggaaaa agatttttga
20760accactgaaa tttggaggtt gtttgtcacc acagtttaac ctagccccca ttgactgatg
20820cagggctgaa gaatgagtct gaactggatc tggacaagac atgtgaagag cactgcaggc
20880tgagtaaaac tcaagtgttg tctcaaagat aacagtgagc acaatatgtt attagggtga
20940gtgtgggata aataaggtat atcaggtgag aataatgaga aactcaactt caaaagatgg
21000tgctgatttg gactgtggag agattcaaat gccctgctta gcatttgaga ttgtgatggt
21060tgaacaaact aattaagagc ccaaaatgaa ggcttgggat aaatatctga gggtgtctaa
21120tatcccaatt tttcatccta gagtgggcag agtccttgat cccattctag ggagacttcc
21180aaaagaaaaa agacctgcat ttcttcaaca acccacattg agagactttc ctgcactttt
21240gacctatggt taacactcct cacctttcat tctgtcatca gtgttttggg gaaacacctt
21300taactctcta tgatttacag gttatgaagt ggcccttata attccttcca ggggtggaaa
21360agactaatga tgatggtgtc tgagctcaca gccacaagcg ggcatgtgtg ttcagcagcc
21420atgtggctca tgtgctagga gcttactaaa tacaatgttc tacatcattg cttaacacaa
21480ggggagatgc tcctgactca gagggtttaa ttgctcacct gcttcttttt ctgccctctt
21540gggctcctaa aatgaaaaga atcctggggt gataaagtga gtcaaagggg tgccagccac
21600atcacagcaa aatagattcc taaaaaaatc cctggcctaa gatgacagcc ttggctggat
21660aagtttgaat gtgctgatag tggacatggt agaatgaagg tggttgaaat gttcatatta
21720aagaacttct acccagattg caagaaaaga gagaggaatg gagatggcag catgattccc
21780tataataaaa gcagatgatt taagatcagt tatctttgtt ctgaaaaaaa taaagacaga
21840aacaaaagtt tagcctgagg ctacaattaa ttgggcaata agtgagaggc acatatggca
21900tagacagatt taaacatttc tcccttatat taatacaaat actaaaatta caaataaatt
21960gattccaaat aaaacaaata tttaaaaaac ttaatgaata aacaccggag tctacagtag
22020tgttcgaagg agatctcaca aacaagtttg gtttttgaag gttagaactg atggtctaga
22080gaattcatat cattccagag agagaaagag aggaattttt taaaaagaac acttgcagtg
22140tttgaagtga caaaggctgc tgtgacaaaa aggaagggaa agggaatttt ttttaaaaaa
22200gcaagcaaca acaacaaaac cccacaaaaa agcagacaac aaacaaacaa aaaacagagg
22260aagaagtcaa aacatgctgg gctgtgacta cttccaggaa ggggctacaa gaggcagctg
22320gaaattctat ttgctttgca actgtgagtt ttccggcctg cttcctttct aaagtatatt
22380actttgtttt tggttcatga agttatccat ttctgttttc tggaacagct atgtattttc
22440tttatctatc atctatctac ctgcctatca tctatctatc tatttactat ctatcttttc
22500tacctttcac tatcaagagc ttgggtcaag caggatagaa ttccagtgta tgttcactct
22560accatttaaa acaagagctc ttgtaggcat tctccaacac atcataaacc tgagctttct
22620aaaacagggt gtggcaaact accattcatg ggccatgtct gacatagtct gcgtttgtaa
22680gaaaagttgt aatgggacac agccacatac atgtgttaca taatgtctct ggctactttc
22740atggtataac ggaagagctg agtcattgag agagggacca catggcttgg aaaacttaaa
22800atatttaaca tttagccctt cgcagaaaat atttgctgac tcttgttttt aaagatctct
22860gtttagaatg ctaactattg ccttctggat agaatcacaa ctctttacca caatcaacac
22920agcttcaacc ctgcttctat atccagcctc atctattatt tccgctcctc ctccttattt
22980tccttctggc catgctgatg gattgccagc ttcccagatg tgcaagaatc tctcctccct
23040tcccgacatt ctcatgctct ccctctgcct ctcaagaact tcctgtccca tctctcatga
23100cgaatctctt cttcattctt taagatgcag ctcctttgct ccttccttaa agatgtctgt
23160ctggctctat tttgggtgac atgctccttc tgcatctccc agagccagcc tgtgtgtgtc
23220agctacagca tttatttgca tctctgtgtc atatatcacc aaatctgcct aagcttgcgt
23280gagtcactgc atgacaactt cagcctccac cagcattgtc cccactaacc atgaggctta
23340gatatttgtc cagtatgctc ggggttgtgg agtggtagca gtaaccaact ggtgagcatc
23400atttcttaca tcagaatcaa atctgtagat ctctgcaatt cataagtatt tggagtttaa
23460aattagcata aagattttct ttaaaataag aacaaatggc ttgagtaggc ttttggaatg
23520tataatactt ctgctggctc ctttcagtgt tcagtattcc cacatgaatc taaacacaac
23580tctgctctta gtagctgtgt gaccctggga aagtcactca atctccctca gctaaatttt
23640gttgtgtgag taatgagaag agagttgtga tttgtattta gtgagtaata acaaacaaaa
23700ggcatttagc tttctggaac ctggtatgta gtagatcctc atgaaatact aactctgttg
23760ataaaactag actgaaagaa gctttcaaag tcaacagcag tatcatgcag ggaaggatgt
23820agatgagaag ctgctgctgc tgctgctgca gcctacagct cctggaggcc cgttttgtcc
23880atgatttagc aggaatgcac tacctttcca tgaggagaca ctgcccacag aaaccaaggc
23940cattctttga agacaaacat gttttaatag cctttacatt atgtaatagt gtaatataaa
24000taataattta tttacattat tctgttataa cttttgtaca gagctttaca cctagatatt
24060ctgaagttgg tggtctgtga gtggcatcaa gtggtgagtg acacactctg accttgggta
24120gaacaacaca agcattctta tacaccaata acagacaaac agagagccaa atcatgagtg
24180aactcccatt cacaattgct tcaaagagaa taaaatacct aggaatcaaa cttacaaggg
24240atgtgaagga cttcttcaag gagaactaca aaccactgct cgatgaaata aaagaggaca
24300caaacaaatg gaacaacatt ccatgctcat ggataggaag aatcaatatc atgaaaatgg
24360ccatactgcc caaggtaatt tatagattca atgccatttg catcaagcta ccaatgaatt
24420tctttgcaga attggaaaaa actactttaa agttcatatg gaaccaaaaa agagtctgca
24480ttgccaagac aatcctaagc caaaagaaca aacctggagg catcacacta cctgaattcg
24540aactatacta caaggctaca gtaacaaaaa cagattggca ttggtaccaa aacagagata
24600tacaccaatg gaacagagca gagccatcag aaataatacc acacatctac aaccatctga
24660tctttgagaa acctgacaaa aacaagcaat ggggaaagga ttccctattt aataaatggt
24720gcttggaaaa ctggctagcc atacatagaa agctgaaact ggatcccttc cttacacttt
24780atacaaaaat taattcaaga tggattaaag acttacatgt tagacctaaa accataaaaa
24840ccctagaaga aaacctaggc aataccattc aggacatagg catgggcaag gacttcatgc
24900ctaaaacacc gaaagcaatg gcaacaaaag ccaaaatgca caaatgggat ctaattaaac
24960taaagagctt ctgcacagaa aaagaaacta ccatcagagt gaacaggcaa cctacagaat
25020gggagaaaat ttttgcaatc tacccatctg acaaaggact aatatccaga atctacaaag
25080aactcaaatt tataagaaat aaaacaaaca acctcatcaa gaagtgggca aaggatatga
25140acagacactt ctcaaaagaa ggcattttgt gcagccaaca gacacgtgaa aaaatgctca
25200tcactggcca tcagagaaat gcaaatcaaa accacaatga gataccatct cacaccagtt
25260agaatggcga tcattaaaaa gtcaggaaac aacaagtgct ggagaggatg tggagaaata
25320ggaacacttt tacactgttg gtgggactgt aaactagttc aaccattgta gaagatggta
25380tggtgattcc tcaaggatct agaactagaa ataccatttg atccagccat cccattactt
25440ggtatatacc caaaggatta taaatcatgc tgctataaag acacatgcac acgtatgttt
25500atcgcagtgc tattcacaac agcaaagact tggaaccaac ccaaatgtcc atcaatgata
25560gactggatta agaaaatgtg gtacatatac accatggaat actgtgcagc cataaaaaag
25620gatgagttca tttcctttgt aggggcatgg atgaagctgg aaaccatcat tctcagcaaa
25680ctatcacaag cacaagaaac caaacactgc atgttctcac tcataggtgg gaattgaaca
25740atgagaacac ttggacacag gaaggggaac atcacacacc ggggcctgtt gtggggtgga
25800ggaagggggg agggaaagca ttaggagata tacctaatgt aaatgacgag gtaatgggtg
25860tagcacacca acatggcaca tgtatacata tgtaacaaac ctgcacgttg tgcacatgta
25920ccctagaact taaagtataa taataaaaaa aagagtgaaa aaaataaaga agcccatgag
25980aaagatctcc atcaagttca cgcggaatga actccagcaa gacctggaaa atgctcagtt
26040ccacaaaata tctgcgtcca aatactttga gtgcacagct ctggcatcag gttactgtga
26100ggacagaccc tgagatggat ttctggatgg aggctgctgc tggaggagac aatgtcactg
26160cagatggctc atgctgctcc catgctgcag gggccagtga tttggggctc ccacctgctg
26220tcccgttggg gaactgcgga gattcacccc agctgggtgg actctgctgt gtctcctgtc
26280aagaatctcc tcagcttacc ttggtttttc ctttttaaat actctctggt gttttcctct
26340ccagtggggg ctgcatctca ccttagaaga aaagattttc caactagggg ctgtcttggt
26400agctggtcca gaagaaggtc tcctctctct ggagtgaggt ccagccaagt aactccagcc
26460agaactctca ctgagtgcgg ctggatctgc cctgctctcc tcccatcctc ctgtggactg
26520tggaaaccca tccatgccct atgcaaagtc ctgcatctca gactgtaaaa tggcagaagc
26580tgaatttaaa ataaatgatt atattgactc tatgagggaa acagagttct gaggtaggca
26640attggtaagc aagcaattat gtgtaacttg ttagaacact agggtgtttt ttgtcttact
26700gattattttc tggttaacag gctggctagg agccagaggg agagaaagct ggctgggaat
26760tgagaggcat gaagtcacct cagtcccaac atttccatgt aaatgatgat gcgagatggg
26820ctggtggcag gagtccctgg aaatcctcac aatctcagct tttaacttct gtaaaatatt
26880atgtcattta tgatctcttt aacaaataac tttttttcta attataaaag tgtatattct
26940ctttggagga tctttggtga atataaaatg agttataaga aaaagaaaaa ttcataattt
27000tatcactcaa attttgataa ttatattcct gcacttttaa tgaaatgtag aaattttaga
27060ttatactgta cataaaatgt ttctgttttt tcatccaata ttggatcata aacgtcttac
27120atggcataaa ctatatatgt aaatcaacta tttccacacc tggatgcttg atttaaccct
27180ccttatactg ttagccattt aaatgatttc tactttatcc tatgaataac acttccacca
27240gttattattc ttatatataa ctcattcaat catttcataa tcttgttgag catttattta
27300taatttggtt gcctattacc tgagtggatt gtggttatat gtttatatgc ttattccaaa
27360tatagtgcta agattagcat tagagacaac aaaatattta caggttttga aactagaagg
27420agccaaacaa atccatgatc cagctctgca tactctcacc cagccttagt tctctcacac
27480agaaagtgaa gacagtgcta tttgccttgt ggcattgctg tgaacttaaa gaaggcaccg
27540attgtacaca cagcagtgcg cagaccgtgg aaggctgggc tccgaccaac tctaaggaca
27600atcaccatcg gatgccccac gatcctactc tcaggatgcc catatgccat atgccatgtg
27660agtgtcactc agtgaacaca tatttgttga ttataaatta ctcccatgct gttttctttg
27720ttttacatgt tcacaaatct gtaaaaacaa agttacaatt atgaaattaa aagttaacta
27780aaggaggaga ttttcattat ctctgaaatg taacccccca aatccagatt ataaagcaag
27840gaaatgtctt atggcccaac acttgccatc aatacttttt ttatgttagt gggcagggga
27900gggtagtgaa aatgaaggaa tcagagctcc gatgggtgca cattgtcttc cctacaaatc
27960cattgcttgt ccagccttcc ttcctcattg gggctgctct atccttttcc acacatttga
28020actgctcccc tgtaggcctt tctcatttgc tttacttcct agtctgaatt ccatgggacc
28080cacatttaag gagaggggaa caactctggg actggaggaa gatcacctta tgagttatac
28140ctgcctcctt cctctacagt gaacggtctc tggtgtccct gggtgttcag tttctttcca
28200ctcatgtgtt actgactgtt caggtggcaa atggcccatg acctttatgg gattaaaaag
28260aaaaaaaata aaaagctgtg tttctttttt tttaactttt attttaggtt agggggtaca
28320cgggagggtt tgttatacag ttaaatacgt gtcacagggg tttgttgtac ctgttatttc
28380atcatccagg tattaggccc agtatccaat agttatcttt tctgctcctc tccctcctcc
28440caccctcccc ccatcaagta gaccccagtg tcttttgttt ccttctttgt gttcacaagt
28500tcttatcatt tagctcccac ttataagtta gaacatgctg tatttggttt tctgttcctg
28560cgttagtttg ctaaggataa tacccttcag cttcatccat actaatgcaa aagacataat
28620ctcattcttt tttatggctg catattattc catggtgtat atgtagcaca ttttctttat
28680ccaatccgtg actgatgagt atttgggttg attctatgtc tttgctattg tgaatagtgc
28740tgcaatgaac atttgcatgc atgtaacttc atggtagaat gatttatatt catctgggta
28800tataaccagt aatgggattg ctaggtcaaa tgttgtagtt ctgcttttag ctctttgagg
28860aatcaccata ctgctttcca ccacagttga attaacttac actcccacca atggtgtata
28920catgttcact tttccctgca atcttgccaa cttctgttag ttttttagtt tttagtaata
28980gccattctga ctggtgtgag atggtgcctc actgtggttt tgatgagcat ttctctagtg
29040atcagtgatc tagagctttt ttccatatgt ttgtttgcca cgtttgcctt tttttttttt
29100ttttttctta gcccgagtct cgctctgtca cccaggccag agtgcagtgg tgcgatctca
29160gctaactgca agctctgcct ccttggttca cgccattctc ctgcctcagc ctcccaagta
29220gctgggacta caggtgcctg ccaccacacc cggctaattt tttgtatttt tagtagagac
29280ggggtttcac catgttagtc aggatggtct caatctcctg acgttgtgat ccaccctcct
29340tggcctccca aaatgcagga attacaggcg tgagccacca cgcccggcac acatgtttgt
29400ctcctttgga gaagtgtctc tttatgtcct tggcccactt tttaatgggg ttgtttttct
29460cttgtaaatt tgtttaagtt ccttatagat gctggatatt agacctttgt cagatgcata
29520gtttgtaaat actttctccc aatctgcaag ttgcctgttt actttgttga tagtttcttt
29580tgctgtgtag aagctcttta gtttaactag atcccacgtc aatttttgct ttcattgcta
29640ttgcttttgt tgtctttgtc atgaaatctt tgcctgtcct tatgtccagg atggtattgc
29700ctaggttgtc ttccagggtt tttatatttt tgggttttac acttaagtct ttaatccatc
29760ctgagttcat ttttgtgtat ggtgtaagaa aggggcccag ttcaatcttc agcatgtggc
29820tagccagtta tcccagcacc atttattgaa cggagtctcg agtcccggtc ttttgtcccg
29880gaggaaaccg cccactccct gggccccgga accggggcga atgggtggtg ccccgccggc
29940cggcgcggcg gctgtgggcc cagccctcag cccgcgccgg acgctgaccg ttttcccgga
30000gggcgggggt cccgctactc ccggaggccg aggaccgctt ttcctccctg ccttcctccc
30060cccgtccgtc cccggctccc tcccgcccgc ccccagtccc tgcgtcgctc tgtctctccc
30120tccgttcctc cctgcctccc tgcctccctg cctccctcct aacgtccctc cgcccgtcct
30180tccgcccctc taggtctccc gttcctctct ccatctctgc ccgccttccc tcccgcctgg
30240aacgctcagc gtccccggtg tgcgccgggc ctggggtctg cgttccgccg ccaggcgctc
30300cgtgctggca gctgggcggc tgcaggggcc cgggcgggcg ggcgacggtg gcgcgggggc
30360gcagaggagg cgagccgccg gagcggtgtc aggcccggac gctgcgcggg gcccggtgtt
30420tcgcgggacg ggggtctcca cccagcccag gggacgacgc gttttccggg ggtggggggt
30480gggggtgggg agggggcggt caggcggcgg ggtgggctgg tggagaggca ggagagctct
30540gcccgggctg ctcccacagc ccaggcggct gcccgcaaac ccgcgcgtgc gcagtaggcg
30600gcccacctgc tggtacctgg gccggctctg ggatccccgg gatgcccagg aaagaatggc
30660agttctccgc ggtgtggagt ctctcaccgg gcctggacct agaaggcagg aatcccaggc
30720cggtcagccc ggtggagggg gcggggcgga gacacgcccc tccgtagcca gccaggtgtt
30780ccccgcgaaa gagaggccac cgccctgccc cgaaccaccc gaccccgtcc caaccccgcg
30840tcctaaagct cctccagcag agcccggtat tcttcctcgc tgaggggtgc ttccagcgag
30900gcggcctctt ccgaggcctc cagctccccc ggggcctccg tttctaggag aggttgcgcc
30960tgctgcagaa actccgggct cgccaggagc tcatccagca gcaggccgca ggggagtgca
31020gaccagggcg ccggctcctg gagcgcctgg gagggcgccg ggatgccttg catctgcccc
31080tgccgcgcgg aggcggaggc gtccgggggc gcgggctggg gaggtggagc tgccccggct
31140tggggttccc acgccgcccc ggcgacctgg ggaccccggc cccagcccca ccacggactc
31200ccctgggacg tgggtggcgc aagcacccct tggccctgcg gccccgcttg agcgggccca
31260ggctgtgcca ccgcgcaggg gcccggcagg ccgtcgcgct gcgggtcccg gtcctcccgg
31320cttttgcccg ggtgcggagg ccaccgagga gcctgagggt gggagagcgc cccgtccgga
31380ggagccgggg cggcgtaggc gaaatccccg cgcgccgggg caggttggga gaccccctct
31440gccggcgcgg cctggctggg ctgcagcgcg ggggcggccc tcgctgcctg gctcacgaaa
31500gccccctgtg ggagagcccc aggcgcgcag ggcacgtggg gtgcgggaag ccccgttccc
31560cacgcgccgg tgtgggcgaa ggcgacccac gagggagcag ggtgaccccc gccgggggcc
31620gcgctgcaca ggccgcctgc ctgcgcgggc gccctgccac cctgtcccgg gtgcctggcc
31680cttcgattct gaaaccagat ctgaatcctg gactccggga ggcccgtctc tctggccagc
31740tcctcccggg cggcgatgcc tggaaagcga tccttctcaa aggctcggag gagcagggcg
31800gtctgggatc cggtgacggc ggtccgcttt cgccggcctt ctggcgggcc gcgtctcccg
31860ggccagggcc gagattcccg ccggtgctgc ctcagctggc gtgacctctc attctgaaac
31920caaatctgga ccctgggctc cggaatgccg atggcctggg ccagccgttc tctggtggcg
31980atgcccgggt acgggttccg ctcaaagcag gctcgcaggg cctcgctttg gctcggggtc
32040caaacgagtc tccgtcgccg tcctcgtccc cgggcttccg cggggagggt gctgtccgag
32100ggtgtcggga gggccatcgc ggtgagcccc ggccggaatt tcacggacgg acgcgggcag
32160agagaggccg gcgggctccc gtgcacctca gccggactgt gcactgcggc aggtgcagcc
32220aggaggcctg cccggacagc cagccagcca gccagccgcc cttgtaaagg cccacaggca
32280ggcaggctcc accccttcat gaatggcggt gagcccccct gggacagccc gccccacccc
32340ggaagggacc cagggcgtcg aggcctgggg ccggccggcg gggtggtggt ggtggtggtg
32400gtgggggggg ggggtggtgg gggagggcgt ggtggcggtg gtggtggtgg ggccggagag
32460acgaagagga agggggagag gggggagggg ggaggggggc gcgtttcggg ggccggctct
32520ccggacctct ccagggatcc cgcgggaacg ggaagccgct ctctgggctc ccacgcgtcg
32580gcagcaggga gaaaccagcc tgggagggtg gaggggagtg tggaactgaa cctccgtggg
32640agtcttgagt gtgccaggcc ctctctccgt gaaggaggca atgcctgtgg gcgtcgccgt
32700tgccgggacg gtctcgcaca cgcaggcgtg tggctctcgt tcatttccac gtagaagacc
32760agagcgagac cccagagagg agatgcctcc ccggcgtgat ggcctgacga tggattcccg
32820cgtgcggcaa cgtggggagt ctgcagtgtg gccggtttgg aacctggcaa ggagagcgaa
32880ggcaccatgc cgggcttgca cccttccctg catgtttccg ggtgcccgca gagctccggg
32940agcaaacagt cggcatggcc agcctttcgg gggccggaga gacgtgagca acaggccgcc
33000ttgcggaggg caaagccacg cggaaaccaa aatcacgcct ccgtcgtcct gcgtgtggct
33060cctccgtggc cggggctgtc ggcctcgcgc cgcgttgcag ggctcagcct ggggatgtgc
33120ggtctgtgaa ccgcgcgggt gaagacccga cggcaacccg agtcccggtc ttttgtcccg
33180gaggaaaccg cccactccct gggccccgga accggggcga atgggtggtg ccccgccggc
33240cggcgcggcg gctgtgggcc cagccctcag cccgcgccgg acgctgaccg ttttcccgga
33300gggcgggggt cccgctactc ccggaggccg aggaccgctt ttcctccctg ccttcctccc
33360cccgtccgtc cccggctccc tcccgcccgc ccccagtccc tgcgtcgctc tgtctctccc
33420tccgttcctc cctgcctccc tgcctccctg cctccctcct aacgtccctc cgcccgtcct
33480tccgcccctc taggtctccc gttcctctct ccatctctgc ccgccttccc tcccgcctgg
33540aacgctcagc gtccccggtg tgcgccgggc ctggggtctg cgttccgccg ccaggcgctc
33600cgtgctggca gctgggcggc tgcaggggcc cgggcgggcg ggcgacggtg gcgcgggggc
33660gcagaggagg cgagccgccg gagcggtgtc aggcccggac gctgcgcggg gcccggtgtt
33720tcgcgggacg ggggtctcca cccagcccag gggacgacgc gttttccggg ggtggggggt
33780gggggtgggg agggggcggt caggcggcgg ggtgggctgg tggagaggca ggagagctct
33840gcccgggctg ctcccacagc ccaggcggct gcccgcaaac ccgcgcgtgc gcagtaggcg
33900gcccacctgc tggtacctgg gccggctctg ggatccccgg gatgcccagg aaagaatggc
33960agttctccgc ggtgtggagt ctctcaccgg gcctggacct agaaggcagg aatcccaggc
34020cggtcagccc ggtggagggg gcggggcgga gacacgcccc tccgtagcca gccaggtgtt
34080ccccgcgaaa gagaggccac cgccctgccc cgaaccaccc gaccccgtcc caaccccgcg
34140tcctaaagct cctccagcag agcccggtat tcttcctcgc tgaggggtgc ttccagcgag
34200gcggcctctt ccgaggcctc cagctccccc ggggcctccg tttctaggag aggttgcgcc
34260tgctgcagaa actccgggct cgccaggagc tcatccagca gcaggccgca ggggagtgca
34320gaccagggcg ccggctcctg gagcgcctgg gagggcgccg ggatgccttg catctgcccc
34380tgccgcgcgg aggcggaggc gtccgggggc gcgggctggg gaggtggagc tgccccggct
34440tggggttccc acgccgcccc ggcgacctgg ggaccccggc cccagcccca ccacggactc
34500ccctgggacg tgggtggcgc aagcacccct tggccctgcg gccccgcttg agcgggccca
34560ggctgtgcca ccgcgcaggg gcccggcagg ccgtcgcgct gcgggtcccg gtcctcccgg
34620cttttgcccg ggtgcggagg ccaccgagga gcctgagggt gggagagcgc cccgtccgga
34680ggagccgggg cggcgtaggc gaaatccccg cgcgccgggg caggttggga gaccccctct
34740gccggcgcgg cctggctggg ctgcagcgcg ggggcggccc tcgctgcctg gctcacgaaa
34800gccccctgtg ggagagcccc aggcgcgcag ggcacgtggg gtgcgggaag ccccgttccc
34860cacgcgccgg tgtgggcgaa ggcgacccac gagggagcag ggtgaccccc gccgggggcc
34920gcgctgcaca ggccgcctgc ctgcgcgggc gccctgccac cctgtcccgg gtgcctggcc
34980cttcgattct gaaaccagat ctgaatcctg gactccggga ggcccgtctc tctggccagc
35040tcctcccggg cggcgatgcc tggaaagcga tccttctcaa aggctcggag gagcagggcg
35100gtctgggatc cggtgacggc ggtccgcttt cgccggcctt ctggcgggcc gcgtctcccg
35160ggccagggcc gagattcccg ccggtgctgc ctcagctggc gtgacctctc attctgaaac
35220caaatctgga ccctgggctc cggaatgccg atggcctggg ccagccgttc tctggtggcg
35280atgcccgggt acgggttccg ctcaaagcag gctcgcaggg cctcgctttg gctcggggtc
35340caaacgagtc tccgtcgccg tcctcgtccc cgggcttccg cggggagggt gctgtccgag
35400ggtgtcggga gggccatcgc ggtgagcccc ggccggaatt tcacggacgg acgcgggcag
35460agagaggccg gcgggctccc gtgcacctca gccggactgt gcactgcggc aggtgcagcc
35520aggaggcctg cccggacagc cagccagcca gccagccgcc cttgtaaagg cccacaggca
35580ggcaggctcc accccttcat gaatggcggt gagcccccct gggacagccc gccccacccc
35640ggaagggacc cagggcgtcg aggcctgggg ccggccggcg gggtggtggt ggtggtggtg
35700gggggggggg gtggtggggg agggcgtggt ggcggtggtg gtggtggggc cggagagacg
35760aagaggaagg gggagagggg ggagggggga ggggggcgcg tttcgggggc cggctctccg
35820gacctctcca gggatcccgc gggaacggga agccgctctc tgggctccca cgcgtcggca
35880gcagggagaa accagcctgg gagggtggag gggagtgtgg aactgaacct ccgtgggagt
35940cttgagtgtg ccaggccctc tctccgtgaa ggaggcaatg cctgtgggcg tcgccgttgc
36000cgggacggtc tcgcacacgc aggcgtgtgg ctctcgttca tttccacgta gaagaccaga
36060gcgagacccc agagaggaga tgcctccccg gcgtgatggc ctgacgatgg attcccgcgt
36120gcggcaacgt ggggagtctg cagtgtggcc ggtttggaac ctggcaagga gagcgaaggc
36180accatgccgg gcttgcaccc ttccctgcat gtttccgggt gcccgcagag ctccgggagc
36240aaacagtcgg catggccagc ctttcggggg ccggagagac gtgagcaaca ggccgccttg
36300cggagggcaa agccacgcgg aaaccaaaat cacgcctccg tcgtcctgcg tgtggctcct
36360ccgtggccgg ggctgtcggc ctcgcgccgc gttgcagggc tcagcctggg gatgtgcggt
36420ctgtgaaccg cgcgggtgaa gacccgacgg caacccgagt cccggtcttt tgtcccggag
36480gaaaccgccc actccctggg ccccggaacc ggggcgaatg ggtggtgccc cgccggccgg
36540cgcggcggct gtgggcccag ccctcagccc gcgccggacg ctgaccgttt tcccggaggg
36600cgggggtccc gctactcccg gaggccgagg accgcttttc ctccctgcct tcctcccccc
36660gtccccggct ccctcccgcc cgcccccagt ccctgcgtcg ctctgtctct ccctccgttc
36720ctccctgcct ccctgcctcc ctgcctccct cctaacgtcc ctccgcccat ccttccgccc
36780ctctaggtct cccgttcctc tctccatctc tgcccgcctt ccctcccgcc tggaacgctc
36840agcgtccccg gtgtgcgccg ggcctggggt ctgcgttccg ccgccaggcg ctccgtgctg
36900gcagctgggc ggctgcaggg gcccgggcgg gcgggcgacg gtggcgcggg ggcgcagagg
36960aggcgagccg ccggagcggt gtcaggcccg gacgctgcgc ggggcccggt gtttcgcggg
37020acgggggtct ccacccagcc caggggacga cgcgttttcc gggggtgggg ggtgggggtg
37080gggagggggc ggtcaggcgg cggggtgggc tggtggagag gcaggagagc tctgcccggg
37140ctgctcccac agcccaggcg gctgcccgca aacccgcgcg tgcgcagtag gcggcccacc
37200tgctggtacc tgggccggct ctgggatccc cgggatgccc aggaaagaat ggcagttctc
37260cgcggtgtgg agtctctcac cgggcctgga cctagaaggc aggaatccca ggccggtcag
37320cccggtggag ggggcggggc ggagacacgc ccctccgtag ccagccaggt gttccccgcg
37380aaagagaggc caccgccctg ccccgaacca cccgaccccg tcccaacccc gcgtcctaaa
37440gctcctccag cagagcccgg tattcttcct cgctgagggg tgcttccagc gaggcggcct
37500cttccgaggc ctccagctcc cccggggcct ccgtttctag gagaggttgc gcctgctgca
37560gaaactccgg gctcgccagg agctcatcca gcagcaggcc gcaggggagt gcagaccagg
37620gcgccggctc ctggagcgcc tgggagggcg ccgggatgcc ttgcatctgc ccctgccgcg
37680cggaggcgga ggcgtccggg ggcgcgggct ggggaggtgg agctgccccg gcttggggtt
37740cccacgccgc cccggcgacc tggggacccc ggccccagcc ccaccacgga ctcccctggg
37800acgtgggtgg cgcaagcacc ccttggccct gcggccccgc ttgagcgggc ccaggctgtg
37860ccaccgcgca ggggcccggc aggccgtcgc gctgcgggtc ccggtcctcc cggcttttgc
37920ccgggtgcgg aggccaccga ggagcctgag ggtgggagag cgccccgtcc ggaggagccg
37980gggcggcgta ggcgaaatcc ccgcgcgccg gggcaggttg ggagaccccc tctgccggcg
38040cggcctggct gggctgcagc gcgggggcgg ccctcgctgc ctggctcacg aaagccccct
38100gtgggagagc cccaggcgcg cagggcacgt ggggtgcggg aagccccgtt ccccacgcgc
38160cggtgtgggc gaaggcgacc cacgagggag cagggtgacc cccgccgggg gccgcgctgc
38220acaggccgcc tgcctgcgcg ggcgccctgc caccctgtcc cgggtgcctg gcccttcgat
38280tctgaaacca gatctgaatc ctggactccg ggaggcccgt ctctctggcc agctcctccc
38340gggcggcgat gcctggaaag cgatccttct caaaggctcg gaggagcagg gcggtctggg
38400atccggtgac ggcggtccgc tttcgccggc cttctggcgg gccgcgtctc ccgggccagg
38460gccgagattc ccgccggtgc tgcctcagct ggcgtgacct ctcattctga aaccaaatct
38520ggaccctggg ctccggaatg ccgatggcct gggccagccg ttctctggtg gcgatgcccg
38580ggtacgggtt ccgctcaaag caggctcgca gggcctcgct ttggctcggg gtccaaacga
38640gtctccgtcg ccgtcctcgt ccccgggctt ccgcggggag ggtgctgtcc gagggtgtcg
38700ggagggccat cgcggtgagc cccggccgga atttcacgga cggacgcggg cagagagagg
38760ccggcgggct cccgtgcacc tcagccggac tgtgcactgc ggcaggtgca gccaggaggc
38820ctgcccggac agccagccag ccagccagcc gcccttgtaa aggcccacag gcaggcaggc
38880tccacccctt catgaatggc ggtgagcccc cctgggacag cccgccccac cccggaaggg
38940acccagggcg tcgaggcctg gggccggccg gcggggtggt ggtggtggtg gtggtggggg
39000gggggggtgg tgggggaggg cgtggtggcg gtggtggtgg tggggccgga gagacgaaga
39060ggaaggggga gaggggggag gggggagggg ggcgcgtttc gggggccggc tctccggacc
39120tctccaggga tcccgcggga acgggaagcc gctctctggg ctcccacgcg tcggcagcag
39180ggagaaacca gcctgggagg gtggagggga gtgtggaact gaacctccgt gggagtcttg
39240agtgtgccag gccctctctc cgtgaaggag gcaatgcctg tgggcgtcgc cgttgccggg
39300acggtctcgc acacgcaggc gtgtggctct cgttcatttc cacgtagaag accagagcga
39360gaccccagag aggagatgcc tccccggcgt gatggcctga cgatggattc ccgcgtgcgg
39420caacgtgggg agtctgcagt gtggccggtt tggaacctgg caaggagagc gaaggcacca
39480tgccgggctt gcacccttcc ctgcatgttt ccgggtgccc gcagagctcc gggagcaaac
39540agtcggcatg gccagccttt cgggggccgg agagacgtga gcaacaggcc gccttgcgga
39600gggcaaagcc acgcggaaac caaaatcacg cctccgtcgt cctgcgtgtg gctcctccgt
39660ggccgggtct gtcggcctcg cgccgcgttg cagggctcag cctggggatg tgcggtctgt
39720gaaccgcgcg ggtgaagacc cgacggcaac ccgagtcccg gtcttttgtc ccggaggaaa
39780ccgcccactc cctgggcccc ggaaccgggg cgaatgggtg gtgccccgcc ggccggcgcg
39840gcggctgtgg gcccagccct cagcccgcgc cggacgctga ccgttttccc ggagggcggg
39900ggtcccgcta ctcccggagg ccgaggaccg cttttcctcc ctgccttcct ccccccgtcc
39960gtccccggct ccctcccgcc cgcccccagt ccctgcgtcg ctctgtctct ccctccgttc
40020ctccctgcct ccctgcctcc ctgcctccct cctaacgtcc ctccgcccgt ccttccgccc
40080ctctaggtct cccgttcctc tctccatctc tgcccgcctt ccctcccgcc tggaacgctc
40140agcgtccccg gtgtgcgccg ggcctggggt ctgcgttccg ccgccaggcg ctccgtgctg
40200gcagctgggc ggctgcaggg gcccgggcgg gcgggcgacg gtggcgcggg ggcgcagagg
40260aggcgagccg ccggagcggt gtcaggcccg gacgctgcgc ggggcccggt gtttcgcggg
40320acgggggtct ccacccagcc caggggacga cgcgttttcc gggggtgggg ggtgggggtg
40380gggagggggc ggtcaggcgg cggggtgggc tggtggagag gcaggagagc tctgcccggg
40440ctgctcccac agcccaggcg gctgcccgca aacccgcgcg tgcgcagtag gcggcccacc
40500tgctggtacc tgggccggct ctgggatccc cgggatgccc aggaaagaat ggcagttctc
40560cgcggtgtgg agtctctcac cgggcctaga cctagaaggc aggaatccca ggccggtcag
40620cccggtggag ggggcggggc ggagacacgc ccctccgtag ccagccaggt gttccccgcg
40680aaagagaggc caccgccctg ccccgaacca cccgaccccg tcccaacccc gcgtcctaaa
40740gctcctccag cagagcccgg tattcttcct cgctgagggg tgcttccagc gaggcggcct
40800cttccgaggc ctccagctcc cccggggcct ccgtttctag gagaggttgc gcctgctgca
40860gaaactccgg gctcgccagg agctcatcca gcagcaggcc gcaggggagt gcagaccagg
40920gcgccggctc ctggagcgcc tgggagggcg ccgggatgcc ttgcatctgc ccctgccgcg
40980cggaggcgtc cgggggcgcg ggctggggag gtggagcttc cccggcttgg ggttcccacg
41040ccgccccagc gacctgggga ccccggcccc agccccacca cggactcccc tgggacgtgg
41100gtggcgcaag caccccttgg ccctgcggcc ccgcttgagc gggcccaggc tgtgccaccg
41160cgcaggggcc cggcaggccg tcgcgctgcg ggtcccggtc ctcccggctt ttgcccgggt
41220gcggaggcca ccgaggagcc tgagggtggg agagcgcccc gtccggagga gccggggcgg
41280cgtaggcgaa atccccgcgc gccggggcag gttgggagac cccctctgcc ggcgcggcct
41340ggctgggctg cagcgcgggg gcggccctcg ctgcctggct cacgaaagcc ccctgtggga
41400gagccccagg cgcgcagggc acgtggggtg cgggaagccc cgttccccac gcgccggtgt
41460gggcgaaggc gacccacgag ggagcagggt gacccccgcc gggggccgcg ctgcacaggc
41520cgcctgcctg cgcgggcgcc ctgccaccct gtcccgggtg cctggccctt cgattctgaa
41580accagatctg aatcctggac tccgggaggc ccgtctctct ggccagctcc tcccgggcgg
41640cgatgcctgg aaagcgatcc ttctcaaagg ctcggaggag cagggcggtc tgggatccgg
41700tgacggcggt ccgctttcgc cggccttctg gcgggccgcg tctcccgggc cagggccgag
41760attcccgccg gtgctgcctc agctggcgtg acctctcatt ctgaaaccaa atctggaccc
41820tgggctccgg aatgccgatg gcctgggcca gccgttctct ggtggcgatg cccgggtacg
41880ggttccgctc aaagcaggct cgcagggcct cgctttggct cggggtccaa acgagtctcc
41940gtcgccgtcc tcgtccccgg gcttccgcgg ggagggtgct gtccgaaggt gtcgggaggg
42000ccatcgcggt gagccccggc cggaatttca cggacggacg cgggcagaga gaggccggcg
42060ggctcccgtg cacctcagcc ggactgtgca ctgcggcagg tgcagccagg aggcctgccc
42120ggacagccag ccagccagcc agccgccctt gtaaaggccc acaggcaggc aggctccacc
42180ccttcatgaa tggcggtgag cccccctggg acagcccgcc ccaccccgga agggacccag
42240ggcgtcgagg cctggggccg gccggcgggg tggtggtggt ggtggtggtg gggggggggg
42300gtgggggggg agggcgtggt ggcggtggtg gtggtggggc cggagagacg aagaggaagg
42360gggagagggg ggagggggga ggggggcgcg tttcgggggc cggctcttct gacctctcca
42420gggatcccgc gggaacggga agccgctctc tgggctccca cgcgtcggca gcagggagaa
42480accagcctgg gagggtggag gggagtgtgg aactgaacct ccgtgggagt cttgagtgtg
42540ccaggccctc tctccgtgaa ggaggcaatg cctgtgggcg tcgccgttgc cgggacggtc
42600tcgcacacgc aggcgtgtgg ctctcgttca tttccacgta gaagaccaga gcgagacccc
42660agagaggaga tgcctccccg gcgtgatggc ctgacgatgg attcccgcgt gcggcaacgt
42720ggggagtctg cagtgtggcc ggtttggaac ctggcaagga gagcgaaggc accatgccgg
42780gcttgcaccc ttccctgcat gtttccgggt gcccgcagag ctccgggagc aaacagtcgg
42840catggccagc ctttcggggg ccggagagac gtgagcaaca ggccgccttg cggagggcaa
42900agccacgcgg aaaccaaaat cacgcctccg tcgtcctgcg tgtggctcct ccgtggccgg
42960gtctgtcggc ctcgcgccgc gttgcagggc tcagcctggg gatgtgcggt ctgtgaaccg
43020cgcgggtgaa gacccgacgg caacccgagt cccggtcttt tgtcccggag gaaaccgccc
43080actccctggg ccccggaacc ggggcgaatg ggtggtgccc cgccggccgg cgcggcggct
43140gtgggcccag ccctcagccc gcgccggacg ctgaccgttt tcccggaggg cgggggtccc
43200gctactcccg gaggccgagg accgcttttc ctccctgcct tcctcccccc gtccgtcccc
43260ggctccctcc cgcccgcccc cagtccctgc gtcgctctgt ctctccctcc gttcctccct
43320gcctccctgc ctccctccct ccctcctaac gtccctccgc ccatccttcc gcccctctag
43380gtctcccgtt cctctctcca tctctgcccg ccttccctcc cgcctggaac gctcagcgtc
43440cccggtgtgc gccgggcctg gggtctgcgt tccgccgcca ggcgctccgt gctggcagct
43500gggcggctgc aggggcccgg gcgggcgggc gacggtggcg cgggggcgca gaggaggcga
43560gccgccggag cggtgtcagg cccggacgct gcgcggggcc cggtgtttcg cgggacgggg
43620gtctccaccc agcccagggg acgacgcgtt ttccgggggt ggggggtggg ggtggggagg
43680gggcggtcag gcggcggggt gggctggtgg agaggcagga gagctctgcc cgggctgctc
43740ccacagccca ggcggctgcc cgcaaacccg cgcgtgcgca gtaggcggcc cacctgctgg
43800tacctgggcc ggctctggga tccccgggat gcccaggaaa gaatggcagt tctccgcggt
43860gtggagtctc tcaccgggcc tggacctaga aggcaggaat cccaggccgg tcagcccggt
43920ggagggggcg gggcggagac acgcccctcc gtagccagcc aggtgttccc cgcgaaagag
43980aggccaccgc cctgccccga accacccgac cccgtcccaa ccccgcgtcc taaagctcct
44040ccagcagagc ccggtattct tcctcgctga ggggtgcttc cagcgaggcg gcctcttccg
44100aggcctccag ctcccccggg gcctccgttt ctaggagagg ttgcgcctgc tgcagaaact
44160ccgggctcgc caggagctca tccagcagca ggccgcaggg gagtgcagac cagggcgccg
44220gctcctggag cgcctgggag ggcgccggga tgccttgcat ctgcccctgc cgcgcggagg
44280cggaggcgtc cgggggcgcg ggctggggag gtggagctgc cccggcttgg ggttcccacg
44340ccgccccggc gacctgggga ccccggcccc agccccacca cggactcccc tgggacgtgg
44400gtggcgcaag caccccttgg ccctgcggcc ccgcttgagc gggcccaggc tgtgccaccg
44460cgcaggggcc cggcaggccg tcgcgctgcg ggtcccggtc ctcccggctt ttgcccgggt
44520gcggaggcca ccgaggagcc tgagggtggg agagcgcccc gtccggagga gccggggcgg
44580cgtaggcgaa atccccgcgc gccggggcag gttgggagac cccctctgcc ggcgcggcct
44640ggctgggctg cagcgcgggg gcggccctcg ctgcctggct cacgaaagcc ccctgtggga
44700gagccccagg cgcgcagggc acgtggggtg cgggaagccc cgttccccac gcgccggtgt
44760gggcgaaggc gacccacgag ggagcagggt gacccccgcc gggggccgcg ctgcacaggc
44820cgcctgcctg cgcgggcgcc ctgccaccct gtcccgggtg cctggccctt cgattctgaa
44880accagatctg aatcctggac tccgggaggc ccgtctctct ggccagctcc tcccgggcgg
44940cgatgcctgg aaagcgatcc ttctcaaagg ctcggaggag cagggcggtc tgggatccgg
45000tgacggcggt ccgctttcgc cggccttctg gcgggccgcg tctcccgggc cagggccgag
45060attcccgccg gtgctgcctc agctggcgtg acctctcatt ctgaaaccaa atctggaccc
45120tgggctccgg aatgccgatg gcctgggcca gccgttctct ggtggcgatg cccgggtacg
45180ggttccgctc aaagcaggct cgcagggcct cgctttggct cggggtccaa acgagtctcc
45240gtcgccgtcc tcgtccccgg gcttccgcgg ggagggtgct gtccgagggt gtcgggaggg
45300ccatcgcggt gagccccggc cggaatttca cggacggacg cgggcagaga gaggccggcg
45360ggctcccgtg cacctcagcc ggactgtgca ctgcggcagg tgcagccagg aggcctgccc
45420ggacagccag ccagccagcc agccgccctt gtaaaggccc acaggcaggc aggctccacc
45480ccttcatgaa tggcggtgag cccccctggg acagcccgcc ccaccccgga agggacccag
45540ggcgtcgagg cctggggccg gccggcgggg tggtggtggt ggtggtgggg ggggggggtg
45600gtgggggagg gcgtggtggc ggtggtggtg gtggggccgg agagacgaag aggaaggggg
45660agagggggga ggggggaggg gggcgcgttt cgggggccgg ctctccggac ctctccaggg
45720atcccgcggg aacgggaagc cgctctctgg gctcccacgc gtcggcagca gggagaaacc
45780agcctgggag ggtggagggg agtgtggaac tgaacctccg tgggagtctt gagtgtgcca
45840ggccctctct ccgtgaagga ggcaatgcct gtgggcgtcg ccgttgccgg gacggtctcg
45900cacacgcagg cgtgtggctc tcgttcattt ccacgtagaa gaccagagcg agaccccaga
45960gaggagatgc ctccccggcg tgatggcctg acgatggatt cccgcgtgcg gcaacgtggg
46020gagtctgcag tgtggccggt ttggaacctg gcaaggagag cgaaggcacc atgccgggct
46080tgcacccttc cctgcatgtt tccgggtgcc cgcagagctc cgggagcaaa cagtcggcat
46140ggccagcctt tcgggggccg gagagacgtg agcaacaggc cgccttgcgg agggcaaagc
46200cacgcggaaa ccaaaatcac gcctccgtcg tcctgcgtgt ggctcctccg tggccgggtc
46260tgtcggcctc gcgccgcgtt gcagggctca gcctggggat gtggggtctg tgaaccgcgc
46320gggtgaagac ccgacggcaa cccgagtccc ggtcttttgt cccggaggaa accgcccact
46380ccctgggccc cggaaccggg gcgaatgggt ggtgccccgc cggccggcgc ggcggctgtg
46440ggcccagccc tcagcccgcg ccggacgctg accgttttcc cggagggcgg gggtcccgct
46500actcccggag gccgaggacc gcttttcctc cctgccttcc tccccccgtc cccggctccc
46560tcccgcccgc ccccagtccc tgcgtcgctc tgtctctccc tccgttcctc cctgcctccc
46620tgcctccctg cctccctcct aacgtccctc cgcccatcct tccgcccctc taggtctccc
46680gttcctctct ccatctctgc ccgccttccc tcccgcctgg aacgctcagc gtccccggtg
46740tgcgccgggc ctggggtctg cgttccgccg ccaggcgctc cgtgctggca gctgggcggc
46800tgcaggggcc cgggcgggcg ggcgacggtg gcgcgggggc gcagaggagg cgagccgccg
46860gagcggtgtc aggcccggac gctgcgcggg gcccggtgtt tcgcgggacg ggggtctcca
46920cccagcccag gggacgacgc gttttccggg ggtggggggt gggggtgggg agggggcggt
46980caggcggcgg ggtgggctgg tggagaggca ggagagctct gcccgggctg ctcccacagc
47040ccaggcggct gcccgcaaac ccgcgcgtgc gcagtaggcg gcccacctgc tggtacctgg
47100gccggctctg ggatccccgg gatgcccagg aaagaatggc agttctccgc ggtgtggagt
47160ctctcaccgg gcctggacct agaaggcagg aatcccaggc cggtcagccc ggtggagggg
47220gcggggcgga gacacgcccc tccgtagcca gccaggtgtt ccccgcgaaa gagaggccac
47280cgccctgccc cgaaccaccc gaccccgtcc caaccccgcg tcctaaagct cctccagcag
47340agcccggtat tcttcctcgc tgaggggtgc ttccagcgag gcggcctctt ccgaggcctc
47400cagctccccc ggggcctccg tttctaggag aggttgcgcc tgctgcagaa actccgggct
47460cgccaggagc tcatccagca gcaggccgca ggggagtgca gaccagggcg ccggctcctg
47520gagcgcctgg gagggcgccg ggatgccttg catctgcccc tgccgcgcgg aggcggaggc
47580gtccgggggc gcgggctggg gaggtggagc tgccccggct tggggttccc acgccgcccc
47640ggcgacctgg ggaccccggc cccagcccca ccacggactc ccctgggacg tgggtggcgc
47700aagcacccct tggccctgcg gccccgcttg agcgggccca ggctgtgcca ccgcgcaggg
47760gcccggcagg ccgtcgcgct gcgggtcccg gtcctcccgg cttttgcccg ggtgcggagg
47820ccaccgagga gcctgagggt gggagagcgc cccgtccgga ggagccgggg cggcgtaggc
47880gaaatccccg cgcgccgggg caggttggga gaccccctct gccggcgcgg cctggctggg
47940ctgcagcgcg ggggcggccc tcgctgcctg gctcacgaaa gccccctgtg ggagagcccc
48000aggcgcgcag ggcacgtggg gtgcgggaag ccccgttccc cacgcgccgg tgtgggcgaa
48060ggcgacccac gagggagcag ggtgaccccc gccgggggcc gcgctgcaca ggccgcctgc
48120ctgcgcgggc gccctgccac cctgtcccgg gtgcctggcc cttcgattct gaaaccagat
48180ctgaatcctg gactccggga ggcccgtctc tctggccagc tcctcccggg cggcgatgcc
48240tggaaagcga tccttctcaa aggctcggag gagcagggcg gtctgggatc cggtgacggc
48300ggtccgcttt cgccggcctt ctggcgggcc gcgtctcccg ggccagggcc gagattcccg
48360ccggtgctgc ctcagctggc gtgacctctc attctgaaac caaatctgga ccctgggctc
48420cggaatgccg atggcctggg ccagccgttc tctggtggcg atgcccgggt acgggttccg
48480ctcaaagcag gctcgcaggg cctcgctttg gctcggggtc caaacgagtc tccgtcgccg
48540tcctcgtccc cgggcttccg cggggagggt gctgtccgag ggtgtcggga gggccatcgc
48600ggtgagcccc ggccggaatt tcacggacgg acgcgggcag agagaggccg gcgggctccc
48660gtgcacctca gccggactgt gcactgcggc aggtgcagcc aggaggcctg cccggacagc
48720cagccagcca gccagccgcc cttgtaaagg cccacaggca ggcaggctcc accccttcat
48780gaatggcggt gagcccccct gggacagccc gccccacccc ggaagggacc cagggcgtcg
48840aggcctgggg ccggccggcg gggtggtggt ggtggtggtg gggggggggg gtggtggggg
48900agggcgtggt ggcggtggtg gtggtggggc cggagagacg aagaggaagg gggagagggg
48960ggagggggga ggggggcgcg tttcgggggc cggctctccg gacctctcca gggatcccgc
49020gggaacggga agccgctctc tgggctccca cgcgtcggca gcagggagaa accagcctgg
49080gagggtggag gggagtgtgg aactgaacct ccgtgggagt cttgagtgtg ccaggccctc
49140tctccgtgaa ggaggcaatg cctgtgggcg tcgccgttgc cgggacggtc tcgcacacgc
49200aggcgtgtgg ctctcgttca tttccacgta gaagaccaga gcgagacccc agagaggaga
49260tgcctccccg gcgtgatggc ctgacgatgg attcccgcgt gcggcaacgt ggggagtctg
49320cagtgtggcc ggtttggaac ctggcaagga gagcgaaggc accatgccgg gcttgcaccc
49380ttccctgcat gtttccgggt gcccgcagag ctccgggagc aaacagtcgg catggccagc
49440ctttcggggg ccggagagac gtgagcaaca ggccgccttg cggagggcaa agccacgcgg
49500aaaccaaaat cacgcctccg tcgtcctgcg tgtggctcct ccgtggccgg ggctgtcggc
49560ctcgcgccgc gttgcagggc tcagcctggg gatgtggggt ctgtgaaccg cgcgggtgaa
49620gacccgacgg caacccgagt cccggtcttt tgtcccggag gaaaccgccc actccctggg
49680ccccggaacc ggggcgaatg ggtggtgccc cgccggccgg cgcggcggct gtgggcccag
49740ccctcagccc gcgccggacg ctgaccgttt tcccggaggg cgggggtccc gctactcccg
49800gaggccgagg accgcttttc ctccctgcct tcctcccccc gtccccggct ccctcccgcc
49860cgcccccagt ccctgcgtcg ctctgtctct ccctccgttc ctccctgcct ccctgcctcc
49920ctccctccct cctaacgtcc ctccgcccat ccttccgccc ctctaggtct cccgttcctc
49980tctccatctc tgcccgcctt ccctcccgcc tggaacgctc agcgtccccg gtgtgcgccg
50040ggcctggggt ctgcgttccg ccgccaggcg ctccgtgctg gcagctgggc ggctgcaggg
50100gcccgggcgg gcgggcgacg gtggcgcggg ggcgcagagg aggcgagccg ccggagcggt
50160gtcaggcccg gacgctgcgc ggggcccggt gtttcgcggg acgggggtct ccacccagcc
50220caggggacga cgcgttttcc gggggtgggg ggtgggggtg gggagggggc ggtcaggcgg
50280cggggtgggc tggtggagag gcaggagagc tctgcccggg ctgctcccac agcccaggcg
50340gctgcccgca aacccgcgcg tgcgcagtag gcggcccacc tgctggtacc tgggccggct
50400ctgggatccc cgggatgccc aggaaagaat ggcagttctc cgcggtgtgg agtctctcac
50460cgggcctgga cctagaaggc aggaatccca ggccggtcag cccggtggag ggggcggggc
50520ggagacacgc ccctccgtag ccagccaggt gttccccgcg aaagagaggc caccgccctg
50580ccccgaacca cccgaccccg tcccaacccc gcgtcctaaa gctcctccag cagagcccgg
50640tattcttcct cgctgagggg tgcttccagc gaggcggcct cttccgaggc ctccagctcc
50700cccggggcct ccgtttctag gagaggttgc gcctgctgca gaaactccgg gctcgccagg
50760agctcatcca gcagcaggcc gcaggggagt gcagaccagg gcgccggctc ctggagcgcc
50820tgggagggcg ccgggatgcc ttgcatctgc ccctgccgcg cggaggcgga ggcgtccggg
50880ggcgcgggct ggggaggtgg agctgccccg gcttggggtt cccacgccgc cccggcgacc
50940tggggacccc ggccccagcc ccaccacgga ctcccctggg acgtgggtgg cgcaagcacc
51000ccttggccct gcggccccgc ttgagcgggc ccaggctgtg ccaccgcgca ggggcccggc
51060aggccgtcgc gctgcgggtc ccggtcctcc cggcttttgc ccgggtgcgg aggccaccga
51120ggagcctgag ggtgggagag cgccccgtcc ggaggagccg gggcggcgta ggcgaaatcc
51180ccgcgcgccg gggcaggttg ggagaccccc tctgccggcg cggcctggct gggctgcagc
51240gcgggggcgg ccctcgctgc ctggctcacg aaagccccct gtgggagagc cccaggcgcg
51300cagggcacgt ggggtgcggg aagccccgtt ccccacgcgc cggtgtgggc gaaggcgacc
51360cacgagggag cagggtgacc cccgccgggg gccgcgctgc acaggccgcc tgcctgcgcg
51420ggcgccctgc caccctgtcc cgggtgcctg gcccttcgat tctgaaacca gatctgaatc
51480ctggactccg ggaggcccgt ctctctggcc agctcctccc gggcggcgat gcctggaaag
51540cgatccttct caaaggctcg gaggagcagg gcggtctggg atccggtgac ggcggtccgc
51600tttcgccggc cttctggcgg gccgcgtctc ccgggccagg gccgagattc ccgccggtgc
51660tgcctcagct ggcgtgacct ctcattctga aaccaaatct ggaccctggg ctccggaatg
51720ccgatggcct gggccagccg ttctctggtg gcgatgcccg ggtacgggtt ccgctcaaag
51780caggctcgca gggcctcgct ttggctcggg gtccaaacga gtctccgtcg ccgtcctcgt
51840ccccgggctt ccgcggggag ggtgctgtcc gaaggtgtcg ggagggccat cgcggtgagc
51900cccggccgga atttcacgga cggacgcggg cagagagagg ccggcgggct cccgtgcacc
51960tcagccggac tgtgcactgc ggcaggtgca gccaggaggc ctgcccggac agccagccag
52020ccagccagcc gcccttgtaa aggcccacag gcaggcaggc tccacccctt catgaatggc
52080ggtgagcccc cctgggacag cccgccccac cccggaaggg acccagggcg tcgaggcctg
52140gggccggccg gcggggtggt ggtggtggtg gtgggggggg ggggtggtgg gggagggcgt
52200ggtggcggtg gtggtggtgg ggccggagag acgaagagga agggggagag gggggagggg
52260ggaggggggc gcgtttcggg ggccggctct tctgacctct ccagggatcc cgcgggaacg
52320ggaagccgct ctctgggctc ccacgcgtcg gcagcaggga gaaaccagcc tgggagggtg
52380gaggggagtg tggaactgaa cctccgtggg agtcttgagt gtgccaggcc ctctctccgt
52440gaaggaggca atgcctgtgg gcgtcgccgt tgccgggacg gtctcgcaca cgcaggcgtg
52500tggctctcgt tcatttccac gtagaagacc agagcgagac cccagagagg agatgcctcc
52560ccggcgtgat ggcctgacga tggattcccg cgtgcggcaa cgtggggagt ctgcagtgtg
52620gccggtttgg aacctggcaa ggagagcgaa ggcaccatgc cgggcttgca cccttccctg
52680catgtttccg ggtgcccgca gagctccggg agcaaacagt cggcatggcc agcctttcgg
52740gggccggaga gacgtgagca acaggccgcc ttgcggaggg caaagccacg cggaaaccaa
52800aatcacgcct ccgtcgtcct gcgtgtggct cctccgtggc cgggtctgtc ggcctcgcgc
52860cgcgttgcag ggctcagcct ggggatgtgg ggtctgtgaa ccgcgcgggt gaagacccga
52920cggcaacccg agtcccggtc ttttgtcccg gaggaaaccg cccactccct gggccccgga
52980accggggcga atgggtggtg ccccgccggc cggcgcggcg gctgtgggcc cagccctcag
53040cccgcgccgg acgctgaccg ttttcccgga gggcgggggt cccgctactc ccggaggccg
53100aggaccgctt ttcctccctg ccttcctccc cccgtccgtc cccggctccc tcccgcccgc
53160ccccagtccc tgcgtcgctc tgtctctccc tccgttcctc cctgcctccc tgcctccctg
53220cctccctcct aacgtccctc cgcccatcct tccgcccctc taggtctccc gttcctctct
53280ccatctctgc ccgccttccc tcccgcctgg aacgctcagc gtccccggtg tgcgccgggc
53340ctggggtctg cgttccgccg ccaggcgctc cgtgctggca cctgggcggc tgcaggggcc
53400cgggcgggcg ggcgacggtg gcgcgggggc gcagaggagg cgagccgccg gagcggtgtc
53460aggcccggac gctgcgcggg gcccggtgtt tcgcgggacg ggggtctcca cccagcccag
53520gggacgacgc gttttccggg ggtggggggt gggggtgggg atggggcggt caggcggcgg
53580ggtgggctgg tggagaggca ggagagctct gcccgggctg ctcccacagc ccaggcggct
53640gcccgcaaac ccgcgcgtgc gcagtaggcg gcccacctgc tggtacctgg gccggctctg
53700ggatccccgg gatgcccagg aaagaatggc agttctccgc ggtgtggagt ctctcaccgg
53760gcctagacct agaaggcagg aatcccaggc cggtcagccc ggtggagggg gcggggcgga
53820gacacgcccc tccgtagcca gccaggtgtt ccccgcgaaa gagaggccac cgccctgccc
53880cgaaccaccc gaccccgtcc caaccccgcg tcctaaagct cctccagcag agcccggtat
53940tcttcctcgc tgaggggtgc ttccagcgag gcggcctctt ccgaggcctc cagctccccc
54000ggggcctccg tttctaggag aggttgcgcc tgctgcagaa actccgggct cgccaggagc
54060tcatccagca gcaggccgca ggggagtgca gaccagggcg ccggctcctg gagcgcctgg
54120gagggcgccg ggatgccttg catctgcccc tgccgcgcgg aggcggaggc gtccgggggc
54180gcgggctggg gaggtggagc tgccccggct tggggttccc acgccgcccc ggcgacctgg
54240ggaccccggc cccagcccca ccacggactc ccctgggacg tgggtggcgc aagcacccct
54300tggccctgcg gccccgcttg agcgggccca ggctgtgcca ccgcgcaggg gcccggcagg
54360ccgtcgcgct gcgggtcccg gtcctcccgg cttttgcccg ggtgcggagg ccaccgagga
54420gcctgagggt gggagagcgc cccgtccgga ggagccgggg cggcgtaggc gaaatccccg
54480cgcgccgggg caggttggga gaccccctct gccgtcgcgg cctggctggg ctgcagcgcg
54540ggggcggccc tcgctgcctg gctcacgaaa gccccctgtg ggagagcccc aggcgcgcag
54600ggcacgtggg gtgcgggaag ccccgttccc cactcgccgg tgtgggcgaa ggcgacccac
54660gagggagcag ggtgaccccc gccgggggcc gcgctgcaca ggccgcctgc ctgcgcgggc
54720gccctgccac cctgtcccgg gtgcctggcc cttcgattct gaaaccagat ctgaatcctg
54780gactccggga ggcccgtctc tctggccagc tcctcccggg cggcgatgcc tggaaagcga
54840tccttctcaa aggctcggag gagcagggcg gtctgggatc cggtgacggc ggtccgcttt
54900cgccggcctt ctggcgggcc gcgtctcccg ggccagggcc gagattcccg ccggtgctgc
54960ctcagctggc gtgacctctc attctgaaac caaatctgga ccctgggctc cggaatgccg
55020atggcctggg ccagccgttc tctggtggcg atgcccgggt acgggttccg ctcaaagcag
55080gctcgcaggg cctcgctttg gctcggggtc caaacgagtc tccgtcgccg tcctcgtccc
55140cgggcttccg cggggagggt gctgtccgag ggtgtcggga gggccatcgc ggtgagcccc
55200ggccggaatt tcacggacgg acgcgggcag agagaggccg gcgggctccc gtgcacctca
55260gccggactgt gcactgcggc aggtgcagcc aggaggcctg cccggacagc cagccagcca
55320gccagccgcc cttgtaaagg cccacaggca ggcaggctcc accccttcat gaatggcggt
55380gagcccccct gggacagccc gccccacccc ggaagggacc cagggcgtcg aggcctgggg
55440ccggccggcg gggtggtggt ggtggggggg gggggggggg ggggagggcg tggtggcggt
55500ggtggtggtg gggccggaga gacgaagagg aagggggaga ggggggaggg gggagggggg
55560cgcgtttcgg gggccggctc tccggacctc tccagggatc ccgcgggaac gggaagccgc
55620tctctgggct cccacgcgtc ggcagcaggg agaaaccagc ctgggagggt ggaggggagt
55680gtggaactga acctccgtgg gagtcttgag tgtgccaggc cctctctccg tgaaggaggc
55740aatgcctgtg ggcgtcgccg ttgccgggac ggtctcgcac acgcaggcgt gtggctctcg
55800ttcatttcca cgtagaagac cagagcgaga ccccagagag gagatgcctc cccggcgtga
55860tggcctgacg atggattccc gcgtgcggca acgtggggga gtctgcagtg tggccggttt
55920ggaacctggc aaggagagcg aaggcaccat gccgggcttg cacccttccc tgcatgtttc
55980cgggtgcccg cagagctccg ggagcaaaca gtcggcatgg ccagcctttc gggggccgga
56040gagacgtgag caacaggccg ccttgcggag ggcaaagcca cgcggaaacc aaaatcacgc
56100ctccgtcgtc ctgcgtgtgg ctcctccgtg gccgggtctg tcggcctcgc gccgcgttgc
56160agggctcagc ctggggatgt gcggtctgtg aaccgcgcgg gtgaaaaccc gacggcaacc
56220cgagtcccgg tcttttgtcc cggaggaaac cgcccactcc ctgggccccg gaaccggggc
56280gaatgggtgg tgccccgccg gccggcgcgg cggctgtggg cccagccctc agcccgcgcc
56340ggacgctgac cgttttcccg gagggcgggg gtcccgctac tcccggaggc cgaggaccgc
56400ttttcctccc tgccttcctc cccccgtccg tccccggctc cctcccgccc gcccccagtc
56460cctgcgtcgc tctgtctctc cctccgttcc tccctgcctc cctgcctccc tgcctccctc
56520ctaacgtccc tccgcccatc cttccgcccc tctaggtctc ccgttcctct ctccatctct
56580gcccgccttc cctcccgcct ggaacgctca gcgtcccggt gtgcgccggg cctggggtct
56640gcgttccgcc gccaggcgct ccgtgctggc agctgggcgg ctgcaggggc ccgggcggcg
56700ggcgacggtg gcccgggggc gacagggagg aggcgagccg ccggagcggt gtcaggcccg
56760gacgctgcgc ggggcccggt gtttcgcggg acgggggtct ccacccagcc caggggacga
56820cgcgttttcc gggggtgggg ggtggggggt ggggatgggg cggtcaggcg gcggggtggg
56880ctggtggaga ggcaggagag ctctgcccgg gctgctccca cagcccaggc ggctgcccgc
56940aaacccgcgc gtgcgcagta ggcggcccac ctgctggtac ctgggccggc tctgggatcc
57000ccgggatgcc caggaaagaa tggcagttct ccgcggtgtg gagtctctca ccggcctgga
57060cctagaaggc aggaatccca ggccggtcag cccggtggag ggggcggggc ggagacacgc
57120ccctccgtag ccagccaggt gttccccgcg aaagagaggc caccgccctg ccccgaacca
57180cccgaccccg tcccaacccc gcgtcctaaa gctcctccag cagagcccgg tattcttcct
57240cgctgagggg tgcttccagc gaggcgcctc ttccgaggcc tccagctccc ccggggcctc
57300cgtttctagg agaggttgcg cctgctgcag aaactccggg ctcgccagga gctcatccag
57360cagcaggccg caggggagtg cagaccaggg cgccggctcc tggagcgcct gggagggcgc
57420cgggatgcct tgcatctgcc cctgccgcgc ggaggcggag gcgtccgggg ggcgcgggct
57480ggggaggtgg agctgccccg gcttggggtt cccacgccgc cccggcgacc tggggacccc
57540ggccccagcc ccaccacgga ctcccctggg acgtgggtgg cgcaagcacc ccttggccct
57600gcggccccgc ttgagcgggc ccaggctgtg ccaccgcgca ggggcccggc aggccgtcgc
57660gctgcgggtc ccggtcctcc cggcttttgc ccgggtgcgg aggccaccga ggagcctgag
57720ggtgggagag cgccccggct ccggaggagc cggggcggcg taggcgaaat ccccgcgcgc
57780cggggcaggt tgggagatcc cctctgccgg cgcggcctgg ctgggctgca gcgcgggggc
57840ggccctcgct gcctggctca cgaaagcccc ctgtgggaga gccccaggcg cgcgcatccc
57900aatgtctccc catctcccct cacacacttc tgacttgagg cacaatagat ttataaataa
57960tggcatgaca agggtctcca gaagtgtgca cagattttcc cagatcccca aaagcaatgc
58020caaactagtc agatcattta tgttctcaca agattctggg aggattttgc ctgtgagttc
58080gaatgcactt taagattctg ggagggagag aaaaagcctt aggggattgc agagtagaat
58140aagcataaga caggaaatgt tcctctgtta cagcaaggaa aatagaagta ggctttctga
58200aaacagtttg cactggagca gagatgacca cagtatattc aaactctggc cttgtccgtg
58260acgtttaata gggttttttg tttttctctt gtaaattttt ttttcattgg tgcagaaatt
58320tgatgaagtc tggcttacag cctgtccact gcagtttatt ttttcaccca gaacagtaac
58380tgggctaatg agaaaatgcc caactcccag tatctccttc aggagagaat taaaacagta
58440gaatatgtgt tgaaatgttt ggctttttga taaattgtct aatgactaga ttctttctct
58500cctgatgtgg agtgctgaag gacatgatgg agtcatatag atgacagttt gtgtctgctg
58560agaagaaaga tgagtgtttg ctacagcact agtgaaactg caataccaca gacagccaac
58620tggggaagaa aatagacaat agaatctaaa atacattgag aaaaaattct ctttaacttg
58680gaaacacagc gaagtccaga gaaaatatat ttgggaatgt gtttgtgaag cacctagaat
58740ctatagcctg gactattgct gtcggtatcc ccctttactg agccagtctt taaatgctag
58800atttgatgag tgctgtatag atccccagat ctctttaaaa aaaaaaaatc acaaggcaca
58860cagagaaggc agaaaatatt ccccattgga agaaaaacat aaatattcag aaactgaatt
58920ttaacaaata aagatttttt gcatatctga tggagaactt aaaataatca tcttatgcat
58980tctcagtgag caaaactata acagaaagag acaactgagt gaaatttaaa aataacgaat
59040gagcaaaata tcaacaaaga gataaaaact atttttaaaa acccaacaga aatcatagag
59100ttgaagaata taataactga gttttataaa ttcactacag agacacaaca gcgaacaatg
59160gagcagaaaa aagaaaattg aacatatatt attcacaaat attgagtcct ggaaactaat
59220attttaaaga atgggaaaat tacgggtgaa atataagact tactggacac catcaagtag
59280accaatacat tcagagatag agtcttttaa aaagaataga gggagaaaat ggcataaaca
59340ttatttcaga gaaaaagcgg ggatgctaag aactttccag atttcaaagc gatgaaagaa
59400aaaatactag caaccaataa taattgatct gggaaatact gtatttcaaa attagaaaaa
59460aataaagact ttcaaagatt aaaataaaaa agctgaggtt gttaactact agaataaccc
59520taggaaaaaa aatgctaaag agagttaatt atgttgaaaa attaaatgat gctggacagc
59580atcataaaac cacatgaaaa tataaagctc tctgttcaat gtaaatatat acacagatat
59640acaattttct actataatgg tgcattaaat tcttaaatct ctgtgaaaat acaaatcata
59700tataaagata caatttgtaa tgttaagaaa gtgacggaag taaaaatgaa tatattttgt
59760atgttgttaa ggtgaagttg aaggcaaaag ccatttgccc tggggacctt agcaatgggc
59820aagggaggag gcaaggctgc cattttctct ccctcatttc ttccatctcc ccttactctg
59880catagggatt tttcttggtc tgcaggaata gtcaatgggc caggctctgt cctgcgtgca
59940caaacacaca cacacacaca ggtgcaggtg ggcatggcat gtatacgcgg aacctgggat
60000tttaatttta aaatttttaa aaagtgggaa accaaggatt tttggcatga ttctcaggac
60060tttgggctgg ggaaagggta agtctttgct ttctgccatg tggcatgcca tcagttgttg
60120gggctttctc cctcaaggtg tcccccaagg agattgtgca ggagatttac ccggtgctca
60180tggtccgtga agacatgtgt caccgcacct gcttctcact gcccctggac agcaacatgc
60240tggaccactt ctcagagatg tgcaacattg aggagcggca ggagggctca gggctgtgtg
60300tgagggaagg ctgttttgga agttcggtgg actgccttgg ggacggcccc cagaagcagg
60360gccaggaagc acttccccac ttctctgagg gctctgcgtc agatgagagc atgaaggtgg
60420gattggagct gcgctctgct tgtcaggctg tcacaccagc accttctaac ttcacaaccc
60480gtgagttaaa gaacagcgtt ctgattccaa aaaaaatgag gcagtaccaa gccaggcttg
60540atatcagccc aacaaaattc tataaagaaa aataatgttt aaaaaaaaag aaagaaaagc
60600ttcacagcct ttgagtaggg aagtctgccc cgtgcagcac tgccaactgc tgaggtgaga
60660ttggcatggt tgtaaagcaa aagttctcat gcactcaagt tacctgcggg gaagctactc
60720atgttctcag ggtctacctg cttgttaaga gcaattgtga aaaagatctg tagctcaatg
60780tgtcccataa ttgatcacag aacctttcct ttttcccaaa agaaccacca ttaaaatatc
60840gtgaaacaca cattggaaga cagtgctgaa cttgtgcatc ctgaaaagtt cttaggacac
60900ccctgcatga gggctgcccc tggacagcag ggcaaggttg tggaggcccc agagctctga
60960aagctatgcc tacccaagac actagtgcac aaagaggaag tggccttgtg gctccccaag
61020acctgcctgt gcttcagagg catttggcag aaggtttctt gttaacaagg atccttgcag
61080gaaggagaga gagagagaca gaaagagaca tacagagaga gagactgtgt gtgtgtgtgt
61140gtgtgtgttt gtgtgtgtgt gtgtgtgtgc tgaaaccaga actccacctt atgtgtttat
61200tgtggaattt gaaaatgaaa gcctaaagtt gaaaactaaa atcacacatg accgcaccct
61260gccaactatt tactgtctga gaagggtcgt tccagggtgt aggacccggg taacaccctt
61320ttcccttcct tcctgaaaga gctacacaca ctgctcaaag cctgtatcca catgttccat
61380gtccaagacg agctcaagag cctggaccca tctgccactt tcagcagggt taactgcagc
61440tgcttgttct tcctgagcat cttctccaat ggtgacctga gagttgaggg aggcattggc
61500gccaggattg aacagaggaa aagggagcac ggacactcag gtggtgagga ccaggccatc
61560tcacctggag ggttctggcc ctgagacatc cagacaagca tcacatttag gtgcagacag
61620ctggccttgg gtggctctgt gcttgtcacc ggcctcgggt ccctcaaaca gtggaaatgg
61680aagaatggct tgggaaatgg ccccatcaac tgtgtgtcac ctgagcacat tctcccaggg
61740gtccaggagg ggccatcgtg tctccagaac cagaactgga aggtccaact tccaggggaa
61800gcaaggaaga gtgttcttag tgaagtggag ggcctcacag caagatgcct ggcttaatca
61860agcttggaca tgcctgaagc atgttcagtg actaaaagtg cctaccatga gcagctggaa
61920cccactccct gagagcttca agatgcatgg gtacctcatg tacctgtttg taattacagc
61980caaggaccag caggcagcat tactgcatcc acatggggct tttactggaa ccagtaagtc
62040tctgccagcc cctcacaggc tcctgggatg ccactcattc tgcgtctatg gacagacaac
62100caggacactt gctcagtgcc cacccactcc ttgtggccca cagcccatca ctcaacccca
62160gccccaccat cccctgcttc ctaagccatt cctcatgcca gaagaaaagg caataccttt
62220gtcccacagc ctctgccttg tgtcatgtca tgtgggcgta tggaatgaac tggccagcct
62280aaactccagt gcttatgcct gaggaatctg tccccactgt ctgagtcccc ctctagggag
62340ctgtcagtgg gggagagagc agccctggaa gagaggccca cgtgcttctg tttgacttca
62400gggcagcctc tcagggcaag aacccagaga agatggtggc ctcacagaag cctgtggcag
62460ggctctgggc ttggtggctg aacatctccc tctttgctgc cagccatggg gcccagaacc
62520acccattcat gagggtcacc accacattgc aggtgtgcag ctggacggct ccccaggcag
62580agcctgccat ggactccatg cacacagagg atgcacacct tgaggctgga ctatgaggag
62640aacattcctg aagaggtgca tgaagcctgg tcctgccctc actgggaacc cccttccctc
62700tgggtaccag atagaattct atgcactttc ctggaggctc catgctggtc tgttcatttg
62760gaagtttgag gctgtccatg aggaagtaac aaaaagagat atctcagagc aggttgtgag
62820gcacaggctg agcccttgcc tagtccctcc ctagtccctt tgcagagccg gggctggaac
62880aaggacctgt ggataatgag ggaactgctc tgcaataacc ggcctgagca gctgcttcaa
62940gaaacagcca caatcgaggc acctatagcc tctggtgagt gactggcagc ctcaggccca
63000cctgccatct gtgagcaggt tttcttgcta acagaatgaa agcaaagaaa gctggaataa
63060gcccagccct ctcaggcacc ttgaagtctg ttggggttcc ttgcaaagcc ttctagcctt
63120ctgcttcttg gcagcccaca caagcacctt tttccagcct ctaatgcttt gatgctctgg
63180aaggagaggg ccctagtttt cactaggcta tggggccagg cctatccagc tccctacttc
63240cactaacaac cacagggctc tcacctgggc acacactgcc cagccatagc ccttctaagg
63300cagaagatca tttgtcttgc agtttcagct tgctagggct taaaagttat cagtgctgtt
63360attaagatag agaagtgaga tcatcagcac aggtgacagc acagcccggg ctgctgggga
63420ggctgaggga gagtgtccag cctattctgc cagctgggcc ttgccagggg tgtctcgtga
63480cccagtccct tagagaaaca tgcagacatc tcagcaagga gctggaaggt gcagatcagg
63540gcagcccagc accactgatg gtggagtggg gctacctccc atcaagctgt gtctccacag
63600ctgacccgtg gagccaggag gtgatttaca acatctgcaa ggcagtcagc cccatcagct
63660ctatgccctt caacattcac ttcaactcaa acatcccacc agaaagcagt ggggactggc
63720caatgcagca gccctgcaaa gtggaacaga tcatcctggg gtggggaatc tggggcctgc
63780ctgctcatct gagcactgct ccctgggtgt gtgctctgca ggacccctga aggagggctg
63840tgagctcatc agggagaccc tgagcctgtg gaacatgcct gaggccatgt ccatggggat
63900ttgtgcctac ttgcacctcc ttgctcatct cactacgcta ttggtgactg tgctgaggtg
63960ggcctcgagc atcccctggg ctgtgtcagc acagggctct gggcctggcc tggcattgag
64020ggacggcaaa taaggggcct gggtttgcat tgtcgcctcc tgtggttcca gaaaatgagg
64080aggtccagac ctgcagtact ggaaccctat caaaggggtt aggaggccgc tcactttccc
64140tcagggcccc atgtggagga gctgagggag gttaaggaga ccctggggac tcacttgttc
64200tgtctgggct tcccccagct ccaccctttg ataaccattt tctgggaaga gctcaggaac
64260ctctcgtgct gtagtgaggt ggggccttcc ctcacagggt attggtgagg aggcattctg
64320agactctgtg agtgagaagc taacacagtg cctgagaata ctcatgggag ctgtcatcct
64380ctgtgaccat cacgtgacct tgtagtgttc agactgcctg gcctggcctt gggcttggta
64440aggctgtttt ggggttagct gctttagact cccacttttt ttgcattcaa acagtgactg
64500ttttagtgtt tgtctatggg tttaaaaaat cctaatattt catttatagt agtttcagct
64560tgtatgtatg tatttgtata aattttatta gaagaaagag ggcttaaggc aacagcattt
64620taagaaggtc ttaatggggc atagactttt atgtcacaac agctaatact gacctctttt
64680tctacctttg cataaagtat acgtaggaag tgtagccaga ggtggtgagg ctaagtgtct
64740agagctgagc tgctgggctt gcttgctggc ctgcagtcag gtggactctg gctgtgaggc
64800agtgcccacc ctggatctac atcccccacc ccctctcctt agtccctgag taaccaacac
64860aaggcagtgc taataagcag gggagtgatg ggcattggga accccaatac tatccgggaa
64920gatctgaagg ccatctgggc tggggctgtt gggggtaggg gctgtggctg ccttggcttg
64980tcagggtgcc acccacagat gtgcctgccc tgtgctgctt ctccagcagc cggctgccta
65040tggccctgag cctgtcacac catgcttgct acctcatgct acttgtgttt gaaaaaccat
65100cccaagatgg tgctgctgga tgtgagtgct gaaaaggggg cagcaccttt gtcctggggg
65160attaggagct gaccagattc ctcctgactc cctcccgaaa caagtggggc tggtgctgca
65220atcaatgatg ccccccagaa gatgtgtttg cactggctga acaaatacat gatgcagagg
65280cctaaatgaa gacacatgaa tggggtgtgt agacatcagc tagcagctgg gaaacaggtg
65340tctctcaggc ctctcattct tcagcaagtg tggaatgtgc ccatgccctt gagtgtatac
65400atctggagtg tatacatctg gctgttgctt ttgctgccac tatccccagg cccaatctgg
65460cttaaagtcc aggttttaag taaaaaagat aagaggattt tctgtgttct gggataggaa
65520gccagggatc tgtgtagggc tgcagttggg tgcacattag ttttgtgaca ggatgagagc
65580tgcagtggtt ttattaatcg tgatagcctg ggctggttgt agcttcaggt gaggggaggg
65640agtcagcagt ggtggtcccg gagacatcca tgtgcccagc cctggccttc ctgccctcag
65700gcacagcaaa aggcaccgcc acaggccccg acttccttct ctactctctg cagcccagat
65760gggaaaactt ggaggctaca atctgaatat atttttctcc cattttaacc cgagctgcct
65820aacacacagt gggggcaggg tgggtgaagg gcctggggga aagcagggct ggatcatgga
65880tcccggggga aatttagaga tacagaagtg gctgtcacct ctctgtggaa cccagctcca
65940tacctggtcc ttgccacacc gccctttcta cagagaatag ttccggggcg tttggggatc
66000cctatggccc cgggtggctt cctgtccccc gctgcctgtg ctgcttccct tggctgctgg
66060cagagcccaa catggaggag gaggttgcag ccctgggagc ctgagggagc tcttcccttg
66120cctgctggca gagcccaaca tggaggagga ggttgcagcc ctgggagcct gagggagctc
66180ttcccttggc ctgctggcag agcccaacat ggaggaggag gttgcagccc tgggagcctg
66240agggagctct tcccttgacc tgctggcaga gcccaacatg gaggaggagg ttgccgccct
66300gggagcctga gggagctgcg tctgactggg gcttctgcct gggggtttgc aaagagctac
66360ttatgaatat agtctctcca gattccttgt ttcaaaggaa gtgagcatga gctagcaagt
66420gtagcaaccc cacagctgat aaacaacttt gtcttggttt taaaccatca catcttcatt
66480tcacattgga ataaagtaag tgaaacctgc tactccagcc ttgcccatgt gttctgtaac
66540ccagtctcct ttggttgtga gggctattgt cagaaatgtt ataagaaaag attatgccat
66600aaattaaatc aaatgtaaaa ttatgcttat aatgtcactt gagtgaaagg taagagggta
66660gagtcacagg cactcagctg gggtttaccc acccatcact taccacactc ataagagtgt
66720gacacaggtg aatgtcactt gacattggtg acagaagaga aaaggctggc atgaaggcca
66780ggtaggggag aggtgccagg ctgtggggcc aggccctggg cgatgctgga cctgtgaggt
66840cactgaacat ctaactgccc aggcactggc ccttttcaca tcagttgagg taagaggatg
66900ggggagcact ctctggaagt cacactgcac tgggagaatg gaggagagtc tacaactcac
66960catcctagtg taggttttag agtgagatgg actgtcttgg agagctaatg aaatgggagg
67020aaagcagtcc cccaggtgca tctgagggcc acagcctatg aagtaagcag tgtgtgtggg
67080agtggcctgt ccctgtgaga ggagaagttt aaagttatta cagctggtgg ctgctgctca
67140gccatccctc tgcagagcag gcaggtcctc agctgcatgt atatctgaat gtcttttgga
67200gtgtttagag agtcctctat gtcttagaaa ttttgaaaag aaaaacaaat ttcaattcta
67260atgtttatta gtttccctga gccaactgga aaaaaaatgt ccttcacctt gaagttttaa
67320gtgacaccca agggtagcca ccagtgtctc agccactgaa gccttgtgca tgctcccact
67380accagtttga tttgcagcct catggttgtg ttgtactaaa tgttctttct tctggccttg
67440tccagtgaaa acggttcaca tggctaacac cacttcttga gatacgggca ccatgtaaag
67500ctgagaatgg attgggttag ttactattgt gcctcctcct cacccgagag gcccatttct
67560cctggttgat tcattaagtg tattagtgct gtcagtcgcc tttggacaac tcaaatgaca
67620agtggctgtt gtttcataaa gaaaatgaag gctttagatg tgaaacactc cttttctctt
67680ctgcttctct taggtgaaag attttatttt tttaaaaagg gtacatagtc gtatcccagc
67740aggtgtagtg tgataactgg catgtgctag gctatggttt cagtgtgtat gggcaattct
67800tcaagatgga aaaccaagtt tcactgagtt gctggagccg cactcacctt ccctccacat
67860ccccaccatg ggcttccact ttcctcccgg gcttgaattt ttttcacatc catattgttt
67920atacacacac acacacacac acacacacac acacacacac acacacatct gtctgtcagt
67980gcagtggctg aatcatgggt cagtgcagcc tcaaactctt aggctcgagt gatcctttca
68040catcagcttc tcaaatagcg aggactacac tacaggcatg caatgctaca cccagccaat
68100taaaaaaaat tttttgtaga aactgagcct acttatgttg cccaaactgg tcttgaactc
68160ataggatcca gcgatcatcc caccttggcc tcccaaattg tttacattac aggtgtgagc
68220taccaaactc agccaaaaat attttttaaa gaacagttac aaccaaatta tgagttatga
68280ttgtgccact gccctccagc ctgggcacca gagcaagacc ttgtatccaa aaataaagca
68340aaacaaaaca agaacaaaaa accttataac caaattaaac ttcgaagatt gtgtcatctg
68400tgtccctctc tgccctccag ttatcaccgt taaatataat ggttattgag aaaacggtta
68460gatattatta agaaatttct atatctactc cagctgagaa taggtattct gatgtggcca
68520aaacattttc tcactgctac cttcagggtc taaactagca gacaaaatca ggacacctgc
68580agaggacagt tggccatttt caaatagaaa cagaaatacc cccattaatg agagtaatcc
68640agtgattttc agaaagacaa gtcagactga catgcagcac agtcagggca caattaccct
68700ggaataatca cttcacacag aatggttgtg gagcctttct aagatgagca aatatgggca
68760acatcattct tgcttattta ttcccagccc ccgctgcccg ccttattctg gcctgattct
68820ggcccgcctg ataatggcca ccccacaatg tggtcagcag tgaggtgcag cgtggtgaga
68880gaggggcttc agggatggga tgagggtctt tcctgcatta tgaaaatgcc taataagttg
68940ttgaaaagat gtccaaatgt tctacttcct acccttaaat agctgctaag atgcatgact
69000caacagatcc tggtaaggga aagagcatgc gcatttcaag tctcagctca cttcttaatt
69060agctgtgata ctctgcgcat gtgaccccaa ctattcgagc ctgtttgcct gtccacccaa
69120gacaatccta agcaaaaaca actggtagct ggaggcatca tgctaccaga cttcaaacta
69180tacttcaagg ctacagtaac caaaacacca cggtactggt accaaacaga tatatagacc
69240aatggaacag aacaaagacc tcagaaataa caccacacat ctacaaccat ctgatcttcg
69300acaagcctga caaaaacaag caatggggaa agattttcta tttaacaaat ggtgctgaaa
69360aaactggcta gccatatgca gaaaacagaa actgcacccc ttccttacac cttaaacatt
69420atctcaagat ggattaaagt cttaaatgta aaaccccaaa ccataaaaac cctagaagaa
69480aacctaggca ataccattca ggacataggt atgagcaaag acttcatgac taaaatacca
69540aaagcaattg caacaaaagc caaaattgac aaatgagatc taattaaaga gcttctgcac
69600agcaaaagaa gctatcatca gagtgaaagg caacctacag aatgagaaaa tttttgcaat
69660ctatccatct gacaaaggtc taacatctgg aatctacaag gaactcaaat gaattcacaa
69720gaaaaaaaaa accatcaaaa agtgggcaga ggatatgaac agactcttct caaaagaaga
69780tatttgactg agtgtggtgg ctcacacctg taatcccagc actttggaac gtggaggcag
69840gtggatcatg aggtcaggag tttgagacca gcctggccaa catgctgaaa tcttgtctct
69900actgaaaaca caaaaaatta gccagacata ttggcaggtg cctgtaatcc cagcttctcg
69960ggaggctgaa gcaggagaat cacttgaacc cgggaaacag atgttgcagt gagccaagat
70020cctgccactg cattccagcc tgggtgacag agcaagactt cgtctcaaag aagaagaaga
70080agaaggagaa gaaggagaag aagaagacat ttatgtggcc aaaaaatatt ttaaaaaatc
70140tcatcatcac tggttattag agaaaggcaa atcaaaacca caatgagata ccatctcaca
70200ccagttggaa tggcaattat taaaaagtca ggaaacaaca gatgctggtg aggctgtgga
70260gaaacagaaa cgtttttaca ctgctggagg gagggtaaat tagttcaacc attgtggaag
70320acagtgtggt gattcctcaa ggatctacaa gcagaaatac catttgaccc agcaatccca
70380ttactgggta tatatccaaa ggaatataaa tcattctact ataaagacac atgcacattt
70440acgtttattg cagcactgtt tacaatagca aagacttgga accaacccaa atgcccatca
70500atgatagact ggaaaaagaa aatgtggcac atatacacca tggaatacta tgcagccata
70560aaaaagaata agttcatgtc ctttgcaggg acgtgagtga agctggaaac cattatcctc
70620agcaaactaa cacagggaac aggaaaccaa acaccatatg ttctcactca tatgtgggag
70680ttgaacaatg agaacagatg tacaccggaa ggaaacatca cacgctgggg cctgttaggg
70740ggttggggtc aaggggaggg agagcattag gacaaatatc taatgcacgt ggggcttaaa
70800acctaaatgg caaggttgac ggtgcagaaa accaccatgg cacatgtaaa cctctgtaac
70860aaacctgcac gttctgcaca tgtatcccaa aacttaaagt aaaacaaaga aacaaacaaa
70920aatgcactaa cgctcagggt gagtggggca ggggccgggg tggggtgcgg atgggtgggt
70980cctggcgttt tattcaatca gtggcgctgg tgtgggaacc acccaatcgg gcgcacagtt
71040tgagaagaga ggagggcgtg gcttccggcg tttggcgggg cctttgtctc tcgctggtgc
71100tggtgcagga gcttgggatc catctcctct ttcgcctcct ccaccttggg aaatccagac
71160aactccctca cagcccctgt tgccctgtga atctgtaggt ccttggggac acacagttaa
71220ggtgctgtta ccatggggtg gtctttgctc ccagagcgcc caagatggtg gcgggccact
71280tccataattt tggcaggcca cttccaagat ggtggcaagc ctcctgttct ctgacctggg
71340gctcttggcc tcacggattc caaggaatgg aatcttgagc catgcggtga gtgttatagc
71400tctattagaa gctgtgggtc acggaagaga accgtggaac ccagtgacta gtgttcagct
71460tgattaggat gaacccaggc gcttagctgt gcaggaacaa tggcaagcct tcagcccgat
71520cgggagtggc aatggatgcc tcgctggatc aggagcagag cggacacctt gctagccagg
71580atggtcttga tctcctgacc ttgtgatccg cccgcctcgg cctcccaaag tgctgggatt
71640acaggtgtga gccatcgtgc ccagccaaga actgtcttca caacaactgg tgctggggaa
71700attaggtacc cacatgtaaa agaatgaacc tgtgcccttc acttatactg taagaaaaaa
71760ttaactaact ggatcaaata cctaaatgta agagctaaaa ctacaaaatt cttagaataa
71820aatatagggg aaacacgtca taacactgga tttggcagtt tttttttttt aaacaggaca
71880cccacaacac aagaaacaaa agaaaaatag acgaatagga atctatccag aatatgcaaa
71940gaacaattca gcaacaataa aacaaactac ttgtttaaaa tattggcaaa aacttaagca
72000gacatttctc taaaaattat gtaaagtagc taataagcac atgaaaagac actcaacaaa
72060actcatcatt agtgaaatgc aaatctaacc ccaaatgaca tatcacttaa tacccatcag
72120catagctact accaaaagaa aaaaaaaaac agaaaatccg aagtgttggt gaggacgtgg
72180agcaattaga atccttgtac actgttggtg gaaatgtaaa atgctgcagc tgctataaaa
72240taacaacaca gtaactaaaa aatttacaca taaaatcacc atacgatcca gcaatttcac
72300atctgggtat gcagcaaaag atatgaaagc aaagacacaa aataatatac atacacctag
72360gttcatagca gcattactca catcaccaaa aaggtgtttg aattactcaa gtgttgtttg
72420aattaccatc aatgattaat agataaaatg tgatttatac atagagtgga atgttattca
72480gttatgtaaa ataaggaaat tctgacacat ggtacgtcat gcatgaacct taaggacatt
72540gtgcaaagtg acatgagcca gtcataaaag gacaaatact gaatcattcc acttatgaga
72600tacttagagt agttaaattc tagaaaccca aatagaagag tagttcttag gagctagagg
72660gggagtaaca aggagcttat ttaatgggta tagagttttg tttctgcaag ttgaaagaag
72720gtccctatga gtggtaatga cagttgcaaa acaatgtgaa agtagttaat ttttctgagc
72780tgcacactta aaatagctaa aatggttaat tttatgtata ctttaccaca atgtaaaaaa
72840taattttaaa ataaactata gctatctgca atatcatgaa ttaatatcat aaatataatg
72900ttgcatagaa gaaagtagat gtaaaagtat acatattaca caatctcact gttataaaat
72960ccaaaaagtg aacacaactg agcttctggc ttccagtaat aatgaagtaa agtagtttgt
73020tgaacacttc acagataact ataacaaagc tctttggtca cagggctgca gcactgcaat
73080cccagcatgc accaggctca gggagagtgc gctaatcact ggaggaaggg acgaggctcc
73140gcgcctctcg ctggtcttgc tgggagatgc agtctcataa acactcccag ccctttggtc
73200acagggctgc gagcactgca atcccagcat gcaccaggct cagggagagt gcgctaatca
73260ctggaggaag ggacgaggct ccgcgcctct cgctggtctt gctgggagat gcagtctcat
73320aaacactccc agccctttgg tcacagggct gcagcactac aatcctagca tgcaccgggc
73380tccgggaaag tgcgcgtcac cggaggaaga ggcagggctg tgcgcgcctc cctaggattg
73440ttggaagatg cattctcata aacactccca accctttggt caaagggcta caggactaca
73500atcccagcat gcaccaggct ccagggcgag gcgcagccct ggaagaaggg gcagagtggt
73560acccgcccca cctaatatgc tgggagctgt agtccgttac ctactctcag cctgtttgtc
73620ggtaagcttc agagctataa tcccagcatg taccgggatc cggggtccat agccctggag
73680ggaggggcag agcggtgtgg acttcccggt gtccaaagca ctgctgagtt ctgatgctat
73740gccgactctt tgcaaggaga gtgagtacag aggtgcacct ggagggcagg tctgggctga
73800gcattgagga gggtattacc ctacaaagat accttacctt ttcccaaatc gggcgggttg
73860tcctcacccg cttggcccta tccttctcag gttcctcttt cagttgcacc cagggttctt
73920tccagaggag tacgtcttct gcagcccagg gtgctgcctt ctttcctaaa ctgcgtgaga
73980actttcctga tgtccaagac actgtcattg tgccgcagcc ctcttttttc tctagccaga
74040gcacgcactc aaccgttttt gagagaaatc ttccacctgg cctgcttgtg agcagcttca
74100gagctctgca ggggtgacaa gggctgtggc ttcttggaaa ggtcactttc aatggcgcct
74160ttttcacgaa tgtgaaagtc taggcatcag aaaggttaat tattgggttg cataaaatct
74220gctaagagca aaggaaaaaa ccccatttct gaggcgtgag tcttgtgagc cattttcatc
74280aacccactta agtggacaag ctccaaaatg caacctgaag ctactgagta tttaggcatt
74340ttacacttga aatcattggt ctcatctcaa gtcaggcctg gcttgccagt ggctcagagc
74400cacaaatggg acctgatacc tcaggaacag atagtgttcc agctttaccg gaggaacttt
74460taagacgtgg agcacttggg gtcatttgaa acccgctatc ttcagtaggg acttttaatt
74520ctacagagca tgtgcatttt gattttatgt gtcctcaagc tgaccctttg ttcattttaa
74580tagtaaaaaa cacattcctg ggtggagatt taagatgcta gtgaggcatg caatgtatgc
74640acaaatatgt acagctactg cacatgtata accagaagac cagtcagaac atgcttaccg
74700taacacttct ttccaccttc ttatgaaata atcatgcaaa actcccataa agagggtttc
74760tccagcaata attaatgctg tctcactttt atgagcaggc tgccctggaa tctctttctc
74820agactgtacc ggctattctg cacttaattt tcaaaatatt cttttttggg caataaatta
74880tgctgtactt cttttgctgt gtgtctcttg tttaaattat tttaaactaa gaagataaga
74940accaaggtat tacatcagcc atcaacattt ctggtgccat gacctgcgga gacgtttgtc
75000tgcttcatta atttcagttt ccctttactt gcagtgaata ctatggcagt ttcagactac
75060ctggttaact atcgctgctg gttccagcgc tgttccagta aagttctggg ggaaacgttt
75120ttaagtcacc cgcattcttt agagagagaa tatatgtccg ctctcctttt ctctgcggct
75180tctgtagtat cgataaatac gctaaccaca tgggttgccc tcaacatttc atatttgggc
75240tatttgccgc tcattttcac atctttctgg ccacagttta gactcagctt gtcgtttgct
75300gtccgttcag caatactcga tcgccaccta gtggctattg taatttattt tctggtcagg
75360ttttctgttt acaaaatttt tgttttgttt tgagcagcac attaagagaa ccctgtccct
75420tcaggcttta tgcatttccc agctccttga aattgttctt caaccggctt tctttgctga
75480acaaaagatg cacagtcaag cagatgccaa gtcgtaggga ttgcatctga gcattccagg
75540tgttgtaact gggcatcaca aatggcaaac cagtgaatta gagcaaggct tgtcagccag
75600acatctgccc cccagcccgc agtgggggtc atctccgtag ggctggagat gtccaccgct
75660gggggagcta ggacggtgta tggcaaatgc ctatgacctc ctagagcttc agttaatggg
75720gtttcgaggg gatgcgctgg accccttggt gttttcactt ggctcatgag gacgcccaca
75780gcctcctgga cttcagtaaa tgttctgtca ttgcaggatt ctctcggcac catgggagct
75840gcttcctcta ctgtcactga aacacccctg ggatgtatat ctaaaaatta gaacagcttt
75900tggctaaatg aacttagaaa aaagaaaacc ttatcttctt ttgtaatact atttagcctg
75960cctacagatt agctgacaaa acatggctgg agaatgagac tgtgagcttt aactccatcc
76020tacagctaga tcttttctgt agcaatcagg gaaaatggtc tgaagtaccc tatgtgcaag
76080ccgttctggc ctgacaacaa aatccagctc tacgcagcac ctgtgggcta aagcctagta
76140agccagaaag cccctcagaa caattggaag atcatctctt attaagggga agggacccca
76200gaccccacag cccaacacca gctccagaca ggggcactca ggggtccaca cctcctttag
76260aatccccagc atccccacac tatcagagtc ttctgtagaa tctaagcttg tttcacctcc
76320tccttatgct cctttctatc ggcctttgcc aggtacaata gagaccagcc cagctgcagt
76380tactcacagt gggacttcac accatccagg gccagagaaa tttctcccct tacagaaagt
76440cccaaatgga gagaggacca tcagagtgct tgttctactc tcaataaata atctaatcca
76500atataagcaa caactctgat ggccctcaga caacttcagc gcatttactg aaggcttcca
76560ggctctaact ttgaccacca ttcaactgta ccgtccataa atggaccgaa tgactgctgc
76620caacttagct gcacaaaatt ttgcttatta gcaaaaaata gaaaatactt aaaacgtttg
76680ttgctttcac cattttaatg caaaatactt ttgcagcata aatgtcacca taaggtggag
76740ccttgggaat ccagtataaa ctatctcaga aaacctcaat gggtctgcaa caagcagcag
76800agggcctcaa tagacttcaa caatgtctgg actccatggc cactgtagtc cgacaaaagc
76860aaaaagcctg ggatcttctc ccagccgggc aaggaggaac atgtttatat ctaaaagagg
76920aatgctgttt ttgagatcaa tcagcccggc ttagtccaag aaaatattaa aaatatcatc
76980acccaggcag acaaaattga atctctatga acttccatgg gaccatgaaa gcaacgtcta
77040ttacctgcct tactctcttt aatagtaaca gccattacta tactttcagc ttttactttt
77100gttccaattt tgtttaaaat gttaactgat ttcttgctct cttgcttacg gcaactccat
77160gtttgcatga tggttttgca aggctttcaa catttggctg ccaacatctt gcccactggt
77220tccacgaatt acatggttta cacccagtta gatcacacag gaagaaactt tagggcccag
77280actaggtaga aataacaccc actcagcagg aaacagctcc agaaaaagtg acctagcccc
77340tcaacctcca atatgattat gaccctaaga tctcttaggg ggaaactgag gcagaataga
77400tcagaatagt caagaaaatg accatgatct cgggatacag aaatgtgggg aaattataaa
77460tagaactacc atatgatgca gcaatctcat tgctgggttt atatcaaaag gaaacaaaat
77520aagcatgtca aaaaagataa ctgcactctc atgtttatta agcagtattc aaaataaccc
77580aaaccactat ttcttctaag tatttctaaa tttacctttt tttcatatat tacaccctaa
77640acttttaaag gtttcatgtc tggtttccaa tttctgaaac ttacaagtca ctgattcttt
77700gttgccttcc tatttagagt ctggtaaaac aattaaatgc tttttatttc ttctcaatct
77760aatcttcata tataaatata tttatatttt ctattaattt gccttctata acatatatga
77820ctacattaat tgtgatcagc atttcacttt actagccctc tttttggctc agcctatttt
77880aatatgtaat ttgtatgttg tacattaaat tgttttacaa ccctttcaat actttacttt
77940tcatttgcct cttttccaaa gatagcttga caagctcgta gtttctttcc acattatttt
78000ggtttcttgt ttttccatta tattgactta aacatttaaa tataaattca atatctgaga
78060tttatgtgcc atataatttc ttctgatgct tcaccccagt agctcatctc cttgtgtgtg
78120acataattta taatttaatc ctcacatatg ggagacaccg cattccaatg cctgcaggca
78180gtttctcttt gtttattcca tttgccttgt cagaagggaa caacccacac ggacctgaca
78240ttcttgtaat caggcacatc tgagtggagc cctggtctct taggttgatt acttctctgg
78300atcattacct ttatttactt ccagtcctgg gaggttttct taatttcctt tcaactatat
78360taggcattct gtgaattctt gtaacttctt ggtgatttta attgtctgca ttaagtgttt
78420aaagtatatt atttttctga aaagcagaaa tatcaataat tgcatatatg agtgaaatat
78480tttacataga ttttctatgg catctatcac catgagaaat tccaagtttt tttcatttga
78540aacacccctc tcatcaatag accatattgt aataatttgt agagtgtgat tacttttata
78600ccattagaaa attaattata tattatgtac atatttttga aatactccac tgcaataaat
78660agtatatggt cagaagtatt gttttctcta acctaaaact aatatgagta aaattatcta
78720cctgaattca gaccttttgg cttcaatggc cattctgtct cattagcact tccctgatcc
78780ataaaagaca tcattcgtac tttctgctta attcataatt tattgaaatg agtaatttaa
78840tgttataatg ttttatggca atttaggaca ttttcaataa atatattgag ctcaaggccc
78900tggctaagta ttccttttgt gctcaaaatc agatttttct ggcacaactt cattgcctgc
78960aatggtattt ataaaaagta tgaatgccag cacatggact atttcaatac tgtactcatt
79020ttttcatgta taaacatttc attagctatg aaacaaacca aatacaaatg ctgaatgtac
79080agtatatatc aacaaatgca gattcttcac ctaagaaaac aataaaagac gaattttctg
79140tgacatgtca cctgttcatt agttctttaa tatgatttag gctattccaa atataagaaa
79200atgtatgcat cactatttat gttgtctcaa cacatttttt atctaggtcc tgaaggacag
79260aaaaaagaat gtatattgtc agatttattt ttatagattt tagatgtttc ttttgctgta
79320ttttctgtgc atactactat gaatatatgg agacaaggac aaatgagcat ttaagtggtt
79380atatgaattt tgcttatatg gctaattgct tatatggatg ttgtaaatga caagataaaa
79440tagtaaagtt tggtaaactt atctgtgccc tgtgaacttt agttcactta ctgtataact
79500taattcagtc actaataatt aatttaaaaa gtgtttttta aaaactgcaa accacatttt
79560attacacatt tctgaatcag gaaggggtaa actgtgacac agctttctca tgccactgac
79620ttttttgggg agaaacattc tgcaataaaa taagagtttc caaactctat ttataaaaaa
79680gcttgagttt tcttctgtga ttaaccttca ctcctcagtc ccttttaccc aaggaatggt
79740tcctaggtca tcttttggaa gtttagtttc tggaaagttt tcggcaaacc tctcctgagc
79800tttgtcccag ttgttgttgt tcttgttttg gagaaggtga gtctctttaa ttgaggatgg
79860tttgtctgtc tccaatcctg catgtgtttg ccaaggctga agctgtactg gagtttttat
79920tctcccacca tccttcccca ggccttctcc tgttttcaac acatcttttt caacatcttc
79980tgacctttgt tgctatcagt aatttcagaa tgaacagatg caggagcatc atctctttgg
80040aaatttcctt cacttccaat ctgctcccta tgttttccag ctctatcttt atatttttga
80100ttctccagta tcttatcatc tttgtagtct gtattctgta aaccatattt tactcgtata
80160tttttaaaat ccttttcttc tttccaactc gtttccttct tagttaatga tggaccaaca
80220aatgattcat ctttcttgtc aaggaaaagg tgagctctaa cctgccctgg ttcacatcca
80280acacagctat tactgccagt gtgaatgtaa taagataaca cagtgtctcc aactttcact
80340ttatctccat gctcaggttc ataaggctca catttagttt tcagctgaac aatccatttt
80400acattaacaa ttgttccatt ttgactgtct gatccaaaag gacataactt tgtaagtcaa
80460ggtcaaaata gatttctgca tgaaacttac accaacttca gggatttgga aagtatgctc
80520catatcattt tctcttccaa ttgtagcagg ttttgcagca gtaatgatga agaatgatcc
80580tgtctgtagc acaggtgatc taatgacaat cactctcata tatgaggcca cactttttcc
80640tcatcttcct cctcagtatc ttttgcagtt gcattgcctt tactggtaat gccttcatca
80700taactaccct cggtctgaga gtctgtaatt tcaccttctt ctggttcact atcagtctct
80760gtgattttct catccttaaa gatgaattga gatgttttca ttaaaaggag attccatagg
80820atttccacta aatggaacag tgaattttgg ggattatttt tgtgatgaat gcctattttg
80880gctttttttt tttcacattt gtgaaattgt ctttcccgtt gcagcttgta tgttcaacac
80940tgaaggcttc ttgatcctct gaattcaaat ccttttcctc atcgtttttt tgtagaagaa
81000tcctttcttt tctcaatttt tcgtttttgt ttcgtgctat aagtctgata aggttgcaaa
81060tctactcgag aatgaaatcg atagcgacaa ctttccacat cacagtggta ataaattaaa
81120tcataatata tttgattctc agaatcttaa tagaaaccag tgctgtggtc aaaatacagt
81180ccagtatttt catcatcact aaatccagtc tgtgacaaag ccgcttccgc tgcagctctc
81240aaacttccag ctaatgacga accttctaag gacgtatctt gtgctgctaa tgcagatgct
81300ggctcctgtg aattggaggc agatgaccct cttgtctaca cttaacattt gctgtcctat
81360cagtaccagg gtgagtgtca ttttctactt ataactggtc gttagaattc aaagcaggac
81420tttcaatatc ctgatcttgc tgatttgaca gttcagtcac tcactttatt tggaagacta
81480acgtcattag ggtaggtctg ataataataa tctgagattg accaaggagc atggttctct
81540gcgagtactt ctacatcaga cttttattac ctccatgtct cccacagcgg agtacgttac
81600tgagttcttc cagctgcgtg cggagctcct ggcggttgct cgtgtcgctc tgagcagccg
81660tcctgggcga ggccatagct tctcccgttc ccgcacctgc cgcctgcagc tccgcgttcg
81720ggttccagct tctccgccct ccttctccgc tgggccagct cgggctcggg gagggggagg
81780agcggccaca gcgaaggcgc tggcggcggc tacgggcaga ggccgcgagt tcgggaccag
81840acggctgcgt tctcggaggg gctgcgcggg gccggagcgg gggccggcgg agccacagcc
81900ccgggggcgc gcgggcagcc acaggcagcc tccccggcca ggaggccccg aaacgcggag
81960cctgacgggg ctgcggcaag agcaggggga cggcgatggc cctgccggat ctgcgtgcct
82020ggaatccggg gaacgactgc gccttcccca gccccggggg cgcgggagga gcgtcgaagt
82080ccaggggcca gaagcgctcc ggccgttccc gagttgagct gcgaacagcg gccaagcgtg
82140ttttaaatcg agcttccgtg tggcgagcta tgacctgctg gttactctta ttttttttct
82200ccattcgttg agctatgatt gacaaattga aaagtgtgta tttttagggt gtacaataga
82260gtgttttgag atgtcagtgg tctttaaatc acctcagtta agctagttag cctgtctatc
82320ccctcacata gtgaatacgc ctctgtgtgt ggtgagagca cctgagatct actcttgcag
82380caaatttcaa gtacacagta ttgttaacta tagtcactat tctgtacgtt aggtccccag
82440cagttactca ccttgtaact gaaggtgcgc cccttccatg gaaatcttcc cactttcccc
82500acttcctagc ccatgggaac cagcgttcta ctgtttccat ggctttttta aatttttatt
82560tactttttta gattttacat acaaacgaga tcatgcagta gttgtctttc tgtattcagc
82620ttatttcact tagcataatg tcttcaagat ttatcaatat tgttgtggat gaaagagttt
82680catttttatt aaagctgaaa ttatgtctct cagtttatct gtatcagagg aatgcagata
82740cccttgatga tcctgatttt atgtcctttg gctatatact cctaattggg attaatggta
82800gttctagttt aacaatttta aggaacctcc atactgtttt tcataatagc tgcaccaatt
82860gacatcctca gcaacagtgc acaagtgttc tctttttcca caccctaaca ctttttatct
82920tttgactttt tgataatagg tatccaaaca ccacgataag gtgatacctc attgtgattt
82980taattactgt gataattagt gatgttgagc attttttata tacctgctgg ccatttgtat
83040atctttggaa aaattgctat ttatatattt tgcccaatta ttaatcaaga aattgctttt
83100aattctgctg tgggtttttt gtattgatta ctatgacata tattttggat agtaacatat
83160tatcctacat atggtttaca aatattttct cccattccat ataatgcctt tatattttgc
83220tgattgtttc ctttattgtg cagaaaattt ttactttgac atagttccac ttgtttattt
83280ttgcttttgt tgactgcgct cctggtgtca aatccgaaac atcattgcca tgaccagtgt
83340caaggaggct tttccccatt ttttttttta gaggattcat gatttcagtt cttatgttta
83400agtctttatt tcatttcaaa ttcattttgt gatgacatga gagaaaggtt tactttttgt
83460ctgtgcatat cgagtttttc ctacaccact ccttgatgtg tttatccttt ctccattctg
83520tgggattggt cgaatgtata tttgtgagtt tatttctggg tcctctattc tgttctattg
83580gtttttatgt aggtactata ctgtattaat gactacagct ttgtaatata gtttgaaatc
83640aggaagtgtg aggctttcag cctttttgtt cttctcagta tttggctatt tgaggtcttt
83700tgtggttcca tactaatttt aaaattgtcg ttctacattt taataaaatg gcattaaaat
83760tttgataaaa atttaactct gtagatcact ttgtgtagta tggatatttt aacaatatta
83820atttttagaa tccatgaaca catatttccc attttgtatt cttcattttc tttcctcaac
83880attttatagt tttcagtatg cagatctttc atattctttg ttaactcatt cctaagtatt
83940tcattctatt tgataatatt gtaaatggaa ctatctttat tcctgtttca gatattttgt
84000tgttactgta aaaaaaatgc aactgatgtt catatgttaa tattgtatcc tgagaattta
84060ctgacttagt tggttagtta taacaggttt ttttttttct ggtaaaatgg tggttattct
84120gaattctggt taaactttaa attgataatt gctattatca tttcaaaatt atttaaaata
84180tgaccagatg gattcctgct ttcatgaatt caatggaatt caaatcttcc catttaaaat
84240aattttgtct ggttgaccta gaccccgggg atcgggggca ccccgtggga gcccggagat
84300tcgcctgggg gtgggaggga gaagccgtca gagagggggc tgagctgggg aagcagagag
84360gggctcgggg acagccggga ggagagaggg tcgtgtcgga gacccagtgg ggagagagaa
84420tgggccggaa aaggaggaag ggtgagagtg ggcaacagga cggcttcccg gcgcggcagg
84480gaactttgct gaaactgcgg gccccaggga ccagcgcggg cagggtggga gggagtggag
84540aggacccagc agacccgaag gtcagtgtgg agaaagggac gtttcccggt tccttcgtct
84600ctgcccagcg ttctgcgggc gtggccccct ccaggggcag gggaggaggt ggctcccggc
84660gggctcggag aactaagggg cgcacacccg cttcgcaggg ccggggtgac aggggaagcc
84720tgagacggct gcggatctcg ctggccccgt gggtgggcgc gggggacgcg ggaggggccg
84780agctcacggg gccagcgccg gggcctgcag gtggccctgg aggaatctgc aagcacccgc
84840ccgtgcagcg ggccttccgg gagaccagtg tggacagcgc cctggacacg cccttcccag
84900ctggaacatc tgtgaggctg gaatttaagc tccggcagac agggaagcgg ctggaggaag
84960gcctggaaga aacccaagtg caaagcccag cccgagagga ggaagcagaa atgcctgacc
85020tgcgtcaaaa tggactgtga ggataaggtt ctgggcagga tggttcgctg ccctccagag
85080acgcagactc ggcgggagcc tgaggagcac cagggggccg ggtgcagccc ggcggagcgg
85140gcggtgagga ccccacggct gccgcttccc tgcacggttc gcctcctcca aggcccggcc
85200cccagcggag cccagcgctg aatcgcatgg cgccccctgg agccctggcg gggaaaacca
85260gtggaagacc cacctcccag ggagaggacc ccactgtatc cccagataat aaaactgtcc
85320tctcccccaa aaaataaata aataattttg tctggtcttt gaaaatgtgt atcccctgtg
85380tactggtcaa aatgctgccc atttatctat atgcctaatt agccaacttt ttaatgaagt
85440tatttaacat tcttttttat tatgaaacaa aacagtaaat ttgttaatgg ttttaatatc
85500atctaatatg attgaaaata tgtcaatttt tcattgccaa agaatctttg tgttatttat
85560tttactctgt tatgtattct gtccataaag gtctaagtgg cttagaatct tgcctaacat
85620attgtatgtg ctaagtacta actactctaa ttcatcaaat tatctttcta taccattctt
85680aaaatacaat attattttct atttattttt attaaaattt tttgcctaat ctaattattt
85740atgaaaatta tgaggtctat tcagtttgtc ctcttgataa aagccaaagt tttttttttt
85800ctctcttttt tttttttttg agacggagtc tccctctgtt ccccaggctg gagtgcagtg
85860acacaatctc ggctcaccac aacctccgct tcccgggttc aagtgattct cctgcctcag
85920cctcccaagt agctaggact acaggcatgt gccaccacgc ctggctaatt tttgtatttt
85980tagtagagat ggggtttcac tatattggcc aggctggtct tgaactcctg accacgtgat
86040ccgccctcct cagcctccca aagtgctggg attataggct tgagccacct caccaggcct
86100ttttttttat ctctttatta atacgtgaga gagtacaaat gccgctccct tacagaagca
86160tgttgcatag tgatgaagta tgggcttttg gtgtgacaat catctgaatg ttgtttattg
86220tcccaattag ttattttctc attcctaaac cctctccaac ctcccatctt tctgagtctc
86280cagtgtctat ttttccagtc tctatatcca agtgtatgct taattgagtt cccacttaca
86340actgagaaaa tactgaattt gattttctgt ttctgagttt tttcacttac agtaatggcc
86400tccggtttta ttcatgttgt tgcaaaagac atgattttat tcttcatggc tgagtagcat
86460tccatggtat acttgtatag cacattttct ttattcgatt attgattgat aaatttaaat
86520tgatttcata tatcggctat tatgaatagt gctgtgataa acatgtcagc atgggtattt
86580tctttatgta acaaattgtt ttcctttggg tagataccaa gtagtgggag tgctgaatca
86640aatggaagtt ctatttttag tctattttga aatctccata ctgttttcca gaggttgtag
86700aaagttactt tcccacaaac aatgtataag tgttctcttt tccctgtatc cttgccgata
86760gctcattttt ctgcttttta gtaatagcca ttctgcaggg tgtaagttgg tatctcattg
86820tggtttttaa ttggcatttc tctgatcatt gacaaggttg agcatctttt acgtgcttgt
86880tgaccattga ccatcagtgt ctttcttttt tttaatgttc atgttctttg cttgcttttt
86940aatgaggtta cttgttttat ttttgttgag ttgtttgagt tccttgcata ttctggacat
87000tagatctttg tcacatgcaa aactcgtaaa catttatctc attccatagg ttttctgttc
87060actgtgttaa ttaggaagct cattttcagg agctttttag tttaattgag ttgctgttgt
87120ctatttttgt tattgttaca tctgcttttg agatcttagt cataaattct ttgtccaagt
87180caatgtctag aagagtttat cctagagttt cttctagcat ttttatagtt tcaggtctta
87240cattttagtc ttttaatcca tattgagttg atttttgtat atggtgggac ataggggtcc
87300cattccattc ttctgcatac ggaaatataa tttttccagc acaatttgtt gaataggatg
87360tcatttctcc agtgtgtgtt tttgttgact ttgtaaaaga tcagtcattt gtaggtatgt
87420ggctttattt ctaggttctc tattctgtac cattgatcta tgtgtcgatt tatatcagta
87480ccatgctgtt ttggttacta cagccttcta gcataatttt aagtcagata atgtaatatc
87540tccagcttta ttctctttgc ttagatttgc tttgactatt caggctcttt ttgtggttcc
87600ataagaattt tagtgggttt tttttctaat tttataaaaa ataccattgg cattttggta
87660ggaattgcat ttaatatgta gattgttttg ggcagtagag tcattttatt gatcataatt
87720cttccaatcc ataagcatgg gatgtttttc tcatttgtgt catgtacaat ttctttcatc
87780agtgttttgt agttttcctt gaagggatcg ttcatctctt tgaccaattg tatttctaag
87840cattttacct ttttttgtag ctattgtaaa aggaagtgac tttttaattc agttctcagc
87900ttgatcatca ttagtgtata aaaatgctat caacttttgt acgttgattt ttgcatcctg
87960aaacattatt aaatttattt atcaaatctg agttttttgg tggtctttag aatttttgta
88020tatatgatat tatattatca tcaaagaggg acaatttgac tttctaatta caaccacata
88080gatgctccca ccaagatcaa tagacagagt ctctggggag ggcacaagtg atggtatttc
88140tttaagctgg ccatgtgatt atggctggaa gcatgggccg agagccactt agctaagcct
88200tgcctctcaa gtctgtctgt ctttctttct ttcttccttt ctttctttct gtctgtctgt
88260ctttctttct tttctttcga cagagttttc actcattgta caggcaggag tgcagtggca
88320ccatcttggc ccactgcaac ctccacctcc caggttcaag ggattctgca gtctcagcca
88380cccgagtagc taggattaca ggcaccagcc accacacctg gctaattttt gtatgtttta
88440gtagagacat ggtttggcca tgttgcccag gctggtcttg aactcctgac ctcaggttat
88500ctgcccactt ccgcctccca aagtgttggg attacaggca taagtcacca cacccggctg
88560cctctcaagt ttcaatgtgc atatgaatta tttccgattc caggctctct cttagtaatg
88620tgattctgca ggtttggaag cggtccatga attggcttct ttaaaaagtc tcctcttaat
88680gctgatgttt cttccactac atccaatata gtagcactca gctagagaaa gtaggcacag
88740cacagagctc ctgacaccca acactgttac cacaacacaa atacttttgg ctcaaagtgg
88800aagccaccaa tcgccatttt caaacatgtc attttctgct ggctctttgc agtttagaaa
88860gcctagagaa ggcatcaatg tttgagtaag tctgcatttg gaaaacatgt acacatgagt
88920taatacaatg tttattgagc acatactatg tgttcagaag tctgttacag agcactgttc
88980aggaaacatt acatgatgtg agttaatcct catagcaccc tggggagttg ggtgctaagt
89040tttctgtaat tttcaggact taaatgaagg gcctagcatt tctatttttt cttccatttt
89100aaaaattatt tacctggaaa ataaaatgtg cagaataaaa gctatatcga cagatgaagg
89160gatagagaaa aaaggatgaa ctgttcagag agatgtttta tatttatatt taccttcttg
89220tgccttgtgg agcagctact gaatttgcag gaatggaaaa caagttgcta ggtgaggtgt
89280ctctagaagc gctggcttca atgaaaaaga aagtataacc ccccaatata gaattatttg
89340cttccactta tctgcttttc cattttagga aattgtgggc accagctcag gagaggcagc
89400aggagccccc gcccgaatct ctggtctcct ttaatgagtt ctgtgagaga agattctagg
89460gtgaggccag acctggatga ggccttagaa gagggtggat ctgggcaggg ctggaacaga
89520aagtggaccc catgtttctg atgttcatgc tggtggagta tttccagttc tgtctttcct
89580aagccttccc aacagagact tgactcttag agcttgtgta attttaatct gttttagcca
89640cttccctgtc aatttttata acacatgata acaagaaact taagcaaaac tcttagggtt
89700ttttaggaca attatatgag aagctaaaaa cttattttta ccaagataaa agaaatagaa
89760ataatcacaa caacaacaat aattcttctg tccatgaata gtccttcagg tagtgacatc
89820ggaactcaag gaacagcata agggaaatgg agcaaatgca gccaaggccc cctgtgcagc
89880tcccttctcc cttccgacta caggatgctg aattcagcca ttaatccatt tcccttccga
89940ccacaggatg ctgaattcag ccattaatcc atttcccttc cgaccacagg atgctgaatt
90000cagccattaa tccgtttccc ttccgaccac aggatgctga attcagccat taatctgttt
90060gctctagatg aaaagttact ggacagtaga aaccatgaat tcttcatctg tttttctgat
90120ggtcatgtga tatagtttag atgtcccctc caaatctcat attgaatttt aatccccaat
90180gtggcaggtg ggacctgggg aggaggtggt tgaatcactg ggtgagtccc tcatggatct
90240gtgccatcct tgtgatagtg agtactcgtg agatctggtt gtttagaagt gtggcccatc
90300cctcccccat ctttcttgtt tctgcttcta ccatgtgaga tgcctgcttc tctttcacca
90360tgattgtaag cttccccagg ccttcccaga agcagacgct ggtgctatgc ttcctgtaca
90420gcctgcagaa ccatgagcca atcaaactct tttcttataa attacccagt ctcaggtttt
90480ttaaatagca atgcaagaat agcttaatac ctcatatgaa aagaaagcaa ttgatatatt
90540taccagtttg agtacttacc agtttgagtc tccagacctc tgccttgctt caactcaaag
90600aacaggaagg gagcaacctc catctactgc tcctgattat gggagaatct tcagttcatc
90660ttaaaacatt tcagtcaaaa gcaccgtgtt ttatgtagaa gaatgagggt gtctgaaaga
90720atgggtctct ttatttattt ttatttctga gacagggtct ctttccctgt cattctggct
90780ggggtgcagt ggttcactgc agctttgaca ttctgtgctc cagcgattct cccacctcag
90840cctcccaagt agctgggacc acacgtgcac actaccacaa ccagataata tttgtatatt
90900tggcagagat gaggtttttc tatgttgagc atgctggtct tgaactcctg agctcaagtg
90960atcctccagc ctctgccttt caaagtgctg gaattacagg tgtgagccac cacaccgggc
91020agatgggtct taactgattt taatcaggat acatgagcat ggaagacatg cccttaattt
91080ttttcctaat acaatatttg acagttatat aactatgatt tttttattcc tgtgattcat
91140aaggatatga tagtaaaagg ccttgaaagc ctgtaggaaa aaagtgctat attgtgcttg
91200aaaccacctt ttactctgaa agcaagtgcc atccagatac atcttttgag aagatatttt
91260ctcctgctgc attttagtca aacagctgag tgtgtcttga agtagttttt tgatttttaa
91320caggacaagt gtattttcta agaccccaaa ctcaggagtg gccatggggc aaatcaccgc
91380tgcacacatg gaatgcatgc acagcaaatg catttctcat cccgaaccag gggttgttcc
91440ccctgggtgc acacaggaat caccagggag gcttttaaaa ttacctaaac tcaaaaggca
91500atagataagt gaactcagaa tccctgcagt gggacctgag ccatagtgct gtttaaagct
91560ctctgggtga ctatggggta caaccaagcc cccaaactgc tgctttaaat cagcctcttc
91620gggtgaacta gtggcaaatg gtttcctgaa atgaatggtt taaatcagcc ttttctggtg
91680aactagtggc aaatggtttc ctgaaatgaa tggtttaaat cagcctcttc cggtgaacta
91740gtggcaaacg ggttcctgaa ataaatggaa agatttgctg ctgggttgtg ctcttctgat
91800cttacctgca ttacctactt ttccttgccg aactgacctc tgctacgtat tttattcctg
91860attcaatcca gttctactca taccaaatgc atagtatgca ctaggtgccc ttgcattgct
91920gaacctcacc gtggggagag gactttgctg aataataatt gcatcctaaa aaaactcaaa
91980atactggact caaatgatcc tcctgccttg gcctcccaag agctgagact gtaggcatga
92040gccaccgtgc ttggcctata ccctaaaaaa ttaaaactat cttacttact aaattgatgt
92100aaacatggga agacctagaa ggtcaccgaa gtgttacaac ataagtaaat accttggaat
92160attaatatcc atctgatgat gccccgagaa aacatgtccc actttaaaac agtacaaaac
92220agtgctatta ttctgagata tgaagttaaa attttgtgca aataggtaat atttaaattt
92280ttatatatgt ataacattca tgcagaaaga cgtatacaaa gaaatcatgt aaagttcaat
92340gaattattac aaagtgaaca cacgtgtgta acctagaaat agaaccagct tcacagatgt
92400cctggtaacc actttctctc ttttgctccc ccaaagtcac taagatctta agagctaaca
92460gtgtagatca actttgtatt attatacatg ttttattaca gaaaatttaa aacatacaca
92520aaataaaaga aacagtacaa taggcctgtt acccaggctc aacaacaact aataacatgc
92580caattttgtg ttatctatac ttcaactcat ttctcacaca gactttgtta tttattatta
92640ttttttgtgg tataaaatgt gtgctcattg aaggtaaaat cttggctgag cacaatggct
92700taagcctgtg taatcccatc actttggaat gacaaggcag gaggatcatt tgaggtcagg
92760agtttgagag cagcctgggc agcatagtga gaccacatct ttattaaatt ttttttttaa
92820ttaatcaggc gcggtggtgc atgcctgtag ttccagctac ttggtatgtt gacatagcag
92880gatcccttga ttctacgagt ttgaggctac agtgagttgt gattgtgcca ctgcacatca
92940gcctgggtga cagagtgaga ctctgtctca aaaaaaaaat aaataaaggt tcgaccttaa
93000ctagcttttt acacataaac acacccatat aagcaatccc tcttttaaca atagaagtac
93060caaactaaaa atcattagtg tgaacccact tttaactcag actttatctt ttaataagtt
93120tcttttcttt tttttttttt tgaggtaaga tgtgcactca ttgaaaggtc taatcttggc
93180tgggcatggt ggctcacatt cgtaacctca tcactttgga agccagagct caggagtttg
93240agaccagcct aggcaacata acaaggcctc actggggcaa gagagtgaga cctcatctct
93300acaacaattt tttaaaagtt agttgggcat agtggtgcac acttctagtc acagctattt
93360gagaggctga cttgggagga tcactggagt ctgggaggtc aaggctgcag tgagctgtga
93420ttgcaccact gcactccttc cagagggaca gagtgaggct ctgtcaaaaa aaggtacaat
93480tttaactgta catgtttgat acatcaacac atccatataa acaatccctc tcttaaaaat
93540aaaagtaccc aatttaacag ttattaatat tcatatgaat tacctagaag ctttttgttt
93600gttttggttt ggatttttat tgaaagggga cacctagaaa tgtcatttac aatctagatt
93660ttgataaaaa taaggctgag ttttttcttt ttttgagatg gagttttgct ctgtcgccca
93720gctggagtgc agtggattga tctcggctca ccaaaacttc tgcctcccgg gttcaagcaa
93780tcctcctgcc tcccaactag ctgggactac aggcatgagc caccacattc agctaatttt
93840tttttttgta tttttagtgc agatggggct tccttatgtt ggctaggcta gccttgaact
93900cctgacctaa ggtgatccac ccgccttggc ctcgcaaagt gctgggatta caggcataag
93960ccaccatgcc cagccagtcc taagttttgc ctgagaattt ctctttctaa gaaagtacat
94020catatggcag ttacaaggtc tcttttgtct aaaataaata gaatttaata aataaaaatt
94080taaaaaattt acctgagatt aaaggacaaa taaaaacaca tgggtaatat gttctctgta
94140ggaatatatt ttaacaatga cataaattat taataatcac taaatgttgt aataatttat
94200taactaaaat taacaaaatt cctattacga tatctaggaa aatactttct tagagtaaaa
94260tattctcata tcttgagaga gcattggtta aaaacagcaa agatgtgcaa gtcgatgtct
94320tatcaagtac ttactatcac gtaagtagca gacccctctt cacagctttt acagagttat
94380ccaaaacgca gtcatttaca caagagcaga caattttcct agctttctat tgagtttata
94440ggttaatgtt gttacaaaat ttatgaaatt acctgaccaa attttatata ttatttcata
94500atatatcaaa atttatttag atgtcaaatt tcatatcata atattataat atataacgat
94560atcatattat gataagttcc atttactttc agacaatttc actaggcagt gtctgtctac
94620cactaattct tttttcgttc cactatttgc acaggcagca cagctgggaa aacacagact
94680cacccaacac agtctcttcc ctgtgacttt ctcctcctca aggaatcagt tcatcagtca
94740atcaagtcat ttgggactgg aggctgagta ctccttaaca tagaaggtct cgttcctgca
94800tgctttcctc agcagagggg gagacaagaa ggtcctttta ggggacactt gcttggacat
94860agactaggct agttggaggg ctctgaccag cagagacaga ctccgccgca gtaggaaggg
94920atgaggcagc tgttctgaac ctggagctcc accacacctt gtcctgtctc actgaggcag
94980ttttgagagg ctgccctgga atacgtcttg ctggtggatg ttgagaatca atgtgggctt
95040tgacgggatt caggtggtgt ccgcagtgtg aagacaggag ctgatgttca gaatctaggc
95100tgtttgtctt gtgatcagtt gggttacctg tttgagacca agtccatttt cactagggag
95160ggctgaataa agcccacaga acacaatggc gctcccagga tgactgagga agggtgagaa
95220tgggggaaag tttttccacc gagacttttt gctacctcag gaatcggggg ctaattaggt
95280tagcactgac tcaacctaat caattcaatt ttattgcatt tgatctaatt atcttcccca
95340tttttaaggt aggaagggcc atttcatttg gtatttattt tttctctgca tttttatttc
95400atcatatatg tgtggaccta atacaatcaa ccataatttg acatttgttg tttccaagca
95460tttaagaaat tataatatct atgcatacaa tgttaacact atgtataata aattctcttt
95520ctgtgcaaaa tatataacat atgacaatat aggcatgttt aattgtgcat cttgaaaggt
95580gaacaggatc ataaatcctt ccaggtagga actgggacag aaataggaag aaatgcttcc
95640ccgattttcc ggtccctgtg ctcccggttc tttgttttct ggacaccatg acaggatcct
95700gaaaatgtct ccctttaact gtgtctaggt ccccagtaga actacagcaa gaaacttctg
95760attgaggctc taagaagcgg caggaatgag aaaactcttc agccaataag agtaagccac
95820gcccagccga gggacgtata aaaggcaggt ctagcagact aacccacact ctgcctttgg
95880acgtgagaga gagcgcacct ttcacttgag cttcaacatg ggaaagggaa atgaagactc
95940cgatctccac tgctcctcca tccagtgctc cactgaccag ccccctttcc aacagatctc
96000ctttacagaa aagggctcag atgagaagaa accattcaaa gaaaaaggca agaccgcctt
96060ctcccattcc agtgagaagc acatacaaag gcaaggtaag gccttgggct gctcctgtgg
96120agtctggaag gagggttgga atcagggata ctgagctgtg tctttagcag ggttttattt
96180tgagatttgg ggatgggaaa tggcttagtg ccctcagggg acttgagaaa tgtgttcact
96240cgtgacactg gcagaagagc ttcacatgaa agactgatcc gcaaaaatgc atcagagata
96300gactgtggga ctctgcctag ggagaggtga gtcacctaaa ccttctcttg cagcaggatc
96360ggagcccaat ccaaacaagg agaattctga ggaaaccaag ctcaaggccg ggaacagcac
96420tgctggatca ggtaagattt gactctttca aggtgagaag ggacagggaa gcaacacagg
96480ctcccctggc aaggaaactg ggagctcctt ggcagccagg gccgtacaga tcctggacac
96540tggagaacag aagagagctg gggtttggtg gtaacctcag ctcctgtgtg tccaggatgg
96600actaggaatt tcagggtgtt cagttggagg cactttctca aactctcatt gtgttcacag
96660aaccagagtc cagctcatat cgggaaaact gcaggaaaag aaaaatgagt tccaaggaca
96720gctgccaaga cacagcaggt agaatcttgg tgtttgttgt tggtggtggt ggtttttttg
96780tttttggttt gccccaaaag gcaaataatc aggaaacttt tatacgaggc ttgagcggaa
96840agggagttac ttattgacga gtaaattttt gagatcttag cactctgaga atatttgggg
96900actcacaggg ggttcagcct cacttcattc cagtgctgag atggtcagga aggagtggga
96960gagacaagtg gggttcacct gggtgtacag ggggttctgg aaatcagggt ctgtggggac
97020tgctctggtg agtctctcac atgctttctt tgcagggaac tgtccagaaa aggagtgcag
97080cttgtcattg aataaaaaat caagatcctc cactgctgtg cacaacagtg aaatccagga
97140gacctgtgat gcccaccata ggggacattc cagggcttgc actgggcaca gcaagcggca
97200taggtctcgg gccctaggag tccaaacacc gtcaattcga aaaagcttgg tgacttctgt
97260gcgagctatg tcagaggctg tttatcaaga cctagcccag gtgtgggcac agcagatcca
97320ttctccactt acctgtgagc agctgacact gctcactcgg ctccgggggc ctctgtgtgc
97380ccaggtgcag accttgtatt ccatggccac ccaggcagct tatgtcttcc ctgctgagag
97440ctggcttgtc ccagccacac tgccaggtcc tggggaatca gccctggata gagaagccca
97500tcccttccct gggcaggaga taactgagac tgtcagtgga tcagatgagg ctaagctgtg
97560agcaccctga ccctattcag cagagatgca gctctgggaa tgagaacaag gatctgcttc
97620ttctcagatt cttccagatg accagcagtg acaattttag acacactgtg ttaataaatg
97680acagaacctg aagaagtcat aggaaagaaa cttgagcggt atactcagaa tggtgagagc
97740cctgaatttt gcagaccgct aagactatag acaaatttta tatttcatgt tagacatttg
97800atgccttttg gatgtctgat gacagtcatg catttctata taatcagaaa aacattagaa
97860tgtaatcgtg aatttgcata ttttagattg tagaaaagta aatataaaat tatgtgctcc
97920ttttttgttt tttttttttt ttgagacagt cttgctatgt tacccaggct ggagtgcagt
97980ggcacaatct tagctcactg caacctctgc ttcctgggtt caaacaattc tcatgcctca
98040gcctcccaag cagctgggac tacaggcatg tactgctatg cctggctaat tttttttttc
98100ctgtattgtt agtagagaca gagttttgtc actttggcca ggttggcctc gaactcaggt
98160gatctgccag cctccgcctc ccaacgtgct gggattacag gcatgagccg ccttaccaag
98220aaattgcttc tcttttaatc cagaaaaggt tgtaggctct cactcttcca gcctgaaccc
98280atggagtact aatatccaca aaccattaat agcactccct gtgggaaaat gtctatatat
98340ttttagtttg atataattat agtaaaatta ctatgcaagc tgtttacttt taatatttct
98400acataaaatt taagtcaaga tatagtaaat ggtaaatgat tgtacttatt tattgacctg
98460cctcatgttt catttcattt taaacatcct aaatttatat tttattatat tttatacatt
98520tcaattgatt gtactatatt gcaggatatg gagatttcat cacgtactac aatacagtgt
98580attttgttat atttgacgta tattctactt gtattttgta ctgagatcat acactatttc
98640attatctaag tgtattaatt gtttggttgc tttataattt tcattttatg taatgaaata
98700aacaatgttg tttggaattt taaatttctt tcatatggaa tttgtattta ataaa
98755416DNAArtificial Sequencesynthetically generated oligonucleotide
4cacgtctata caccac
16516DNAArtificial Sequencesynthetically generated oligonucleotide
5taaccctaac cctaac
16616DNAArtificial Sequencesynthetically generated oligonucleotide
6tctctgtctc tgtcgc
16740DNAArtificial Sequencesynthetically generated oligonucleotide
7tgcactgacg tcctgtggcc actgggtggc gccagagcat
40840DNAArtificial Sequencesynthetically generated oligonucleotide
8taatctgaat atctgggcct ccgtgtgcag acctgaggtt
40940DNAArtificial Sequencesynthetically generated oligonucleotide
9gtctctgtgt ctgtctctct gtctctgtcg ctaactctat
401022DNAArtificial Sequencesynthetically generated oligonucleotide
10ctcagagccc agtgtcaatc ac
221122DNAArtificial Sequencesynthetically generated oligonucleotide
11cacgaccgct tagaagaacc gg
221222DNAArtificial Sequencesynthetically generated oligonucleotide
12gagacggcct accatgtgct tc
221322DNAArtificial Sequencesynthetically generated oligonucleotide
13gtgagtgctg tgaactcggc tg
221423DNAArtificial Sequencesynthetically generated oligonucleotide
14cagggcctga tttggcttga aac
231523DNAArtificial Sequencesynthetically generated oligonucleotide
15gaagagtagt ctgacctcat ctc
231622DNAArtificial Sequencesynthetically generated oligonucleotide
16cagggcatga tatcctcttt gg
221725DNAArtificial Sequencesynthetically generated oligonucleotide
17cattcaatgg tgttgatgat ggtac
251825DNAArtificial Sequencesynthetically generated oligonucleotide
18ggttagaata cagcgcggac attca
251922DNAArtificial Sequencesynthetically generated oligonucleotide
19gtgaatctcc gaggcaactg tc
222022DNAArtificial Sequencesynthetically generated oligonucleotide
20gagcgcctca gtgtgcaaat ct
222120DNAArtificial Sequencesynthetically generated oligonucleotide
21actgggtggc gccagagcat
202222DNAArtificial Sequencesynthetically generated oligonucleotide
22ctccgtgtgc agacctgagg tt
222320DNAArtificial Sequencesynthetically generated oligonucleotide
23ccctacctac cctccagaga
202420DNAArtificial Sequencesynthetically generated oligonucleotide
24tctctgtctc tgtcgctaac
202520DNAArtificial Sequencesynthetically generated oligonucleotide
25taaccctaac cctaacccta
202620DNAArtificial Sequencesynthetically generated oligonucleotide
26ttagggttag ggttagggtt
202726DNAArtificial Sequencesynthetically generated oligonucleotide
27tggaggttaa acgattattt atctgc
262819DNAArtificial Sequencesynthetically generated oligonucleotide
28acgagtttcc aaggtgctg
192924DNAArtificial Sequencesynthetically generated oligonucleotide
29ctgctacttc aactcctggt gtgc
243023DNAArtificial Sequencesynthetically generated oligonucleotide
30aggcgaattg ggatgtagct cag
233120DNAArtificial Sequencesynthetically generated oligonucleotide
31gcatatgttg tgttttacag
203218DNAArtificial Sequencesynthetically generated oligonucleotide
32gcaacaaatt gataagca
183330DNAArtificial Sequencesynthetically generated oligonucleotide
33taaccctaac cctaacccta accctaaccc
303439DNAArtificial Sequencesynthetically generated oligonucleotide
34gtagacccac gacatactca gcaccggcct caccccatt
393540DNAArtificial Sequencesynthetically generated oligonucleotide
35aaggccagcc gcggttccag acctgcggtg cggccgtgtc
403640DNAArtificial Sequencesynthetically generated oligonucleotide
36taatctgaat atctgggcct ccgtgtgcag acctgaggtt
403740DNAArtificial Sequencesynthetically generated oligonucleotide
37ttgggggcgt gtctcagagc aggaggggtg tggtctggca
403840DNAArtificial Sequencesynthetically generated oligonucleotide
38gtctctgtgt ctgtctctct gtctctgtcg ctaactctat
403940DNAArtificial Sequencesynthetically generated oligonucleotide
39aaagccacca ggcctctaat ccctacctac cctccagaga
404040DNAArtificial Sequencesynthetically generated oligonucleotide
40cctggagaaa tcaagtctgc gaagatccaa aaattaaaat
404140DNAArtificial Sequencesynthetically generated oligonucleotide
41tgcactgacg tcctgtggcc actgggtggc gccagagcat
404240DNAArtificial Sequencesynthetically generated oligonucleotide
42ctgaccacca ggctacagtg tcctgtaacc gccaggcata
404320DNAArtificial Sequencesynthetically generated oligonucleotide
43cgtcccgtag acaaaatggt
204420DNAArtificial Sequencesynthetically generated oligonucleotide
44ttgatggcaa caatctccac
204520DNAArtificial Sequencesynthetically generated oligonucleotide
45cacagtgatg tcacccacga
204620DNAArtificial Sequencesynthetically generated oligonucleotide
46gtgagaatcg ctccgtcctg
204720DNAArtificial Sequencesynthetically generated oligonucleotide
47ggacgagagg ggacaaagga
204821DNAArtificial Sequencesynthetically generated oligonucleotide
48ggtcaaacct ggactctggc a
214920DNAArtificial Sequencesynthetically generated oligonucleotide
49gaagtgggac aggaagtgag
205017DNAArtificial Sequencesynthetically generated oligonucleotide
50cgggaacagg aagtggc
175121DNAArtificial Sequencesynthetically generated oligonucleotide
51ccagtctaat ggtgacctgg g
215220DNAArtificial Sequencesynthetically generated oligonucleotide
52tgagagtcag catgcaccag
205320DNAArtificial Sequencesynthetically generated oligonucleotide
53taccgaggac cacggactaa
205420DNAArtificial Sequencesynthetically generated oligonucleotide
54aatacacggt gcctcttccg
205524DNAArtificial Sequencesynthetically generated oligonucleotide
55caggtatcca tggccccgat gggc
245625DNAArtificial Sequencesynthetically generated oligonucleotide
56ctcggtctct cgaatcggat ccgac
255725DNAArtificial Sequencesynthetically generated oligonucleotide
57gagttatggg cactgcattt tagca
255825DNAArtificial Sequencesynthetically generated oligonucleotide
58ttgttaaacg caggctagat cctga
255925DNAArtificial Sequencesynthetically generated oligonucleotide
59cgccatttta tagacttctg agcag
256025DNAArtificial Sequencesynthetically generated oligonucleotide
60cctaattctt ggcgtaactg gctcg
256125DNAArtificial Sequencesynthetically generated oligonucleotide
61atgcttagga agagggacaa atgca
25
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