VACCINE AGAINST ACINETOBACTER BAUMANNII BASED ON CELLULAR COMPONENTS DEFICIENT IN LIPOPOLYSACCHARIDE

Abstract

The invention refers to a composition comprising inactivated cells deficient in LPS from the genus Acinetobacter and/or outer membrane vesicles form the same and their use for the manufacture of a medicament, preferably a vaccine, for the prevention of diseases produced by organisms of the genus Acinetobacter.

Description

FIELD OF THE INVENTION

[0001] The present invention refers, in general, to the field of pharmacology and immunology, and, in particular, to a vaccine composition suitable for the prophylactic treatment of an infection caused by an Acinetobacter baumannii strain in a mammal.

BACKGROUND OF THE INVENTION

[0002] The increasing clinical importance of infections caused by multidrug resistant A. baumannii warrants the development of novel approaches for the prevention and treatment of infections caused by this pathogen. In this context, immunization of certain patient populations could contribute to reducing the morbidity and mortality caused by this pathogen. Vaccines against Gram-negative bacteria based on inactivated whole bacterial cells are highly immunogenic and have been shown to produce protective immunity against a number of bacterial species. However, the high levels of endotoxin, due to the presence of lipopolysaccharide, in these vaccines complicate their use in humans.

[0003] Acinetobacter baumannii is a Gram-negative coccabacillus with clinical importance in the hospital environment. This organism is highly distributed in soil and environmental water sources (Baumann, P. 1968. J. Bacteriol. 96, 39-42), and can cause different types of infections as a nosocomial pathogen such as pneumonia, bacteremia, meningitis and skin and soft tissue infection, among others (Garcia-Quintanilla et al., 2013. Curr. Pharm. Biotechnol. In press). This pathogen typically infects patients receiving mechanical ventilation and patients sustaining burn injury (Munoz-Price y Weinstein. 2008. N. Engl. J. Med. 358, 1271-1281). However, it has also been isolated in cases of community-acquired pneumonia (Ho et al., 2009. Chest. 136, 1119-1127; Ong et al., 2009. Respirology 14, 1200-1205) and in military personnel sustaining war-related trauma in Vietnam, Iraq, Kuwait and Afghanistan (Jones et al., 2006. Lancet Infect. Dis. 6, 317-318; Tong, 1972. JAMA 219, 1044-1047). The crude mortality rates associated with infection by A. baumannii are between 35% and 70% for nosocomial infections (Vila y Pachon, 2008. Expert Opin. Pharmacother. 9, 587-599). Due to the ability of A. baumannii to acquire resistance to antibiotics, the number of multidrug resistant strains has increased dramatically over the preceding years (Tasbakan et al., 2009. Mikrobiyol Bul. 43, 61-70; Valencia et al., 2009. Infect. Control Hosp. Epidemiol. 30: 257-263). The appearance of these highly resistant strains has complicated the clinical Management of infections caused by A. baumannii. In this context, the development of a vaccine against A. baumannii could reduce the morbidity and mortality caused by this pathogen (Pachon y McConnell, 2014. Vaccine, In press).

[0004] The experimental vaccines that have been described for A. baumannii can be classified into two broad groups, vaccines consisting of a single purified antigen, and multicomponent vaccines. Within the first group, the outer membrane protein OmpA (Luo et al., 2012. PLoS One 7, e29446), the biofilm associated protein Bap (Fattahian et al., 2011. Microb. Pathog. 51, 402-406), the membrane transporter Ata (Bentancor et al., 2012. Infect. Immun. 80, 3381-3388), and the surface polysaccharide poly-N-acetyl-.beta.-(1-6)-glucosamine (Bentancor et al., 2012. Infect Immun 80, 651-656) have been described as good candidates due to their capacity to elicit a specific immune response. However, the experiments testing survival after active immunization have only demonstrated that OmpA provides partial protection, and that the expression of Bap has not been clearly demonstrated in strains that do no form biofilm. The approaches that employ multicomponent vaccines include outer membrane complexes (McConnell et al., 2011. Infect. Immun. 79, 518-526), outer membrane vesicles (outer membrane vesicles; McConnell et al., 2011. Vaccine 29, 5705-5710) and inactivated whole cells (McConnell y Pachon, 2010. Vaccine 29: 1-5). Each of these vaccines induces a strong immune response and is able to elicit high levels of protection against infection in a murine model using the ATCC 19606 strain and clinical isolates. However, in spite of these promising results, the use of these vaccines in humans is complicated in view of the high levels of endotoxin in these vaccines due to the high amounts of lipopolysaccharide (LPS) present in these preparations. LPS is formed by the O antigen, a core polysaccharide and lipid A, which is responsible for the endotoxin activity of LPS. The first studies that employed Escherichia coli demonstrated that the production of LPS was essential for bacterial viability (Raetz, 1990. Annu. Rev Biochem. 59, 129-170). However, subsequent work demonstrated that certain bacterial species, such as Neisseria meningitidis y Moraxella catarrhalis, were viable after mutation of the genes encoding enzymes involved in LPS biosynthesis, resulting in strains completely lacking LPS (Peng et al., 2005. Infect. Immun. 73, 7569-7577; Steeghs et al., 1999. Infect. Immun. 67, 4988-4993). A recent study demonstrated that A. baumannii can acquire resistance to the antibiotic colistin through mutation of the genes involved in LPS biosynthesis IpxA, IpxC and IpxD (Moffatt et al., 2010. Antimicrob. Agents Chemother. 54, 4971-4977), living rise to strains completely deficient in LPS. This results indicate that A. baumannii is also viable in the absence of LPS, raising the possibility of developing vaccines based on these strains.

[0005] Outer membrane vesicles (OMVs) are vesicles derived from the bacterial outer membrane that are secreted from numerous Gram-negative bacteria (Kulp et al., 2010. Annu. Rev. Microbiol. 64, 163-184). OMVs are spherical vesicles of approximately 20-200 nm that are composed of outer membrane proteins, periplasmic proteins and LPS (Kuehn et al., 2005. Genes Dev. 19, 2645-2655; Mashburn et al., 2005. Nature. 437, 422-425). Secreted OMVs have been shown to participate in the detection of quorum sensing, the transport of virulence factors and the transfer of genes, indicating that they play a role in bacterial patogenesis. It has also been demonstrated that OMVs can deliver proteins to the interior of host cells through fusion with lipid rafts, suggesting that OMVs can be used to transport bacterial products over large distances (Kesty et al., 2004. Embo J. 23, 4538-4549). A recent study by Kwon et al demonstrated that a clinical isolate of A. baumannii secreted OMVs during growth in vitro (Kwon et al., 2009. FEMS Microbiol. Lett. 297, 150-156). A proteomic analysis of the OMVs demonstrated that they contain multiple virulence factors and immunomodulating proteins, suggesting that OMVs play an important role in the pathogenesis of A. baumannii.

[0006] Vaccines based on OMVs have been developed for various Gram-negative bacteria including Neisseria meningitidis, Helicobacter pylori, and Vibrio cholerae (Bjune et al., 1991. NIPH Ann. 14, 125-130; Keenan et al., 2003. FEMS Immunol. Med. Microbiol. 36, 199-205; Bishop et al., 2012. J. Infect. Dis. 205, 412-21). Immunization with OMVs has been shown to induce antibodies against multiple bacterial antigens, and the capacity to provide protective immunity in animal models of infection. In addition, the OMVs isolated form N. meningitids serogroup B have been shown to be safe and immunogenic in humans, and have been used to control an outbreak of meningococcus meningitis in New Zealand (Nokleby et al., 2007. Vaccine. 25, 3080-84).

[0007] The infections caused by A. baumannii often occur in outbreaks caused by a single clone. For this reason, a vaccine based on OMVs could be more effective if the OMVs are isolated form the causative clone. The purification of OMVs from bacterial cultures is rapid and simple, requiring only filtering of the culture supernatant and concentration of the OMVs.

BRIEF DESCRIPTION OF THE INVENTION

[0008] Aspect A:

[0009] This aspect of the invention refers to a pharmaceutical composition, preferably a vaccine composition, suitable for the prophylactic treatment (before infection) of an infection caused by an Acinetobacter baumannii strain in a mammal, which comprises:

[0010] a. an Acinetobacter baumannii strain whole cell deficient in lipopolysaccharide (LPS) characterized by the partial or complete inactivation of one or various cellular nucleic acid molecules that encode endogenous LPS; and/or

[0011] b. an outer membrane vesicle (OMV) derived from an Acinetobacter baumannii strain deficient in lipopolysaccharide (LPS) as defined in paragraph a) above.

[0012] In a prefer embodiment of this aspect of the invention, the Acinetobacter baumannii strain deficient in lipopolysaccharide (LPS) is characterized by the partial or complete inactivation of the genes selected from the list consisting of IpxA, IpxB and/or IpxC.

[0013] In another prefer embodiment of this aspect of the invention or of any of its preferred embodiments, the pharmaceutical composition, preferably the vaccine composition, further comprises a, preferably recombinant, polypeptide selected from the list consisting of:

[0014] a. Aminoacid sequence SEQ ID No 27 (putative ferric siderophore receptor (A. baumannii ATCC 17978; accession number YP_001084684)) or a fragment thereof, wherein the term fragment is understood herein as biologically active fragments selected from the list consisting of SEQ ID No 1 to SEQ ID NO 11 or any combination thereof, or an amino acid sequence having at least 85% identity with any of sequences SEQ ID NO 1 to SEQ ID No 11; and/or

[0015] b. Amino acid sequence SEQ ID No 28 (putative ferric hydroximate siderophore receptor (A. baumannii ATCC 17978; accession number YP_001084696)) or a fragment thereof, wherein the term fragment is understood herein as biologically active fragments selected from the list consisting of SEQ ID NO 12 to SEQ ID NO 23 or any combination thereof, or sequences that have at least 85% identity with the amino acids SEQ ID NO 12 to SEC ID NO 23.

[0016] In another prefer embodiment of this aspect of the invention or of any of its preferred embodiments, the pharmaceutical composition, preferably the vaccine composition, further comprises a purified outer membrane protein sequence of A. baumannii selected from the list consisting of: SEQ ID NO: 29, SEQ ID NO: 30, SEQ ID NO: 31, SEQ ID NO: 32, SEQ ID NO: 33, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 36, SEQ ID NO: 37, SEQ ID NO: 38, SEQ ID NO: 39, SEQ ID NO: 40, SEQ ID NO: 41, SEQ ID NO: 42, SEQ ID NO: 43, SEQ ID NO: 44, SEQ ID NO: 45, SEQ ID NO: 46; SEQ ID NO: 47; SEQ ID NO: 48; SEQ ID NO: 49; SEQ ID NO: 50; SEQ ID NO: 51; SEQ ID NO: 52; SEQ ID NO: 53; SEQ ID NO: 54; SEQ ID NO: 55; SEQ ID NO: 56; SEQ ID NO: 57; SEQ ID NO: 58; SEQ ID NO: 59; SEQ ID NO: 60; SEQ ID NO: 61; SEQ ID NO: 62; SEQ ID NO: 63; SEQ ID NO: 64; SEQ ID NO: 65; SEQ ID NO: 66; SEQ ID NO: 67; SEQ ID NO: 68; SEQ ID NO: 69; SEQ ID NO: 70; SEQ ID NO: 71; SEQ ID NO: 72; SEQ ID NO: 73; SEQ ID NO: 74; SEQ ID NO: 75; SEQ ID NO: 76, SEQ ID NO: 77, SEQ ID NO: 78, SEQ ID NO: 79, SEQ ID No: 80, SEQ ID NO: 81, SEQ ID NO: 82, SEQ ID NO: 83, SEQ ID NO: 84, SEQ ID NO: 85, SEQ ID NO: 86, SEQ ID NO: 87, SEQ ID NO: 88, SEQ ID NO: 89, or any combination thereof.

[0017] In yet another prefer embodiment of this aspect of the invention or of any of its preferred embodiments, the pharmaceutical composition, preferably the vaccine composition, further comprises fusion recombinant polypeptides sequences SEQ ID NO 24 and/or 25 and/or the amino acid sequence coded by nucleotide sequence SEQ ID NO 26.

[0018] In yet another prefer embodiment of this aspect of the invention or of any of its preferred embodiments, the Acinetobacter baumannii strain deficient in lipopolysaccharide (LPS) comprises or is transformed, transduced or transfected with a nucleotide sequence capable of coding for any of the amino acid sequences as defined in any of the precedent paragraphs so that such strain is capable of producing the exogenous expression any of these amino acid sequences.

[0019] In yet another prefer embodiment of this aspect of the invention or of any of its preferred embodiments, said pharmaceutical composition, preferably the vaccine composition, further comprises a vector, such as viral vector, a plasmid or an expression cassette comprising a nucleotide sequence capable of coding for any of the amino acid sequences as defined in any of the precedent paragraphs and expressing said amino acid sequences.

[0020] In yet another prefer embodiment of this aspect of the invention or of any of its preferred embodiments, the Acinetobacter baumannii strain deficient in lipopolysaccharide (LPS) is inactivated. Preferably, said strain or cell is derived from ATCC strain 19606.

[0021] Aspect B:

[0022] This aspect of the invention refers to the pharmaceutical composition, preferably the vaccine composition, of the aspect A of the invention or of any of its preferred embodiments, for use in the prophylactic treatment or for the active immunization of an infection caused by A. baumannii in a mammal, preferably in a human.

[0023] Aspect C:

[0024] This aspect of the invention refers to a vaccine composition comprising an antibody (monoclonal or polyclonal) or a fragment thereof, preferably selected from the list consisting of Fab, Fab', Fab'-SH, Fv, scFv, F(ab').sub.2, Vhh, nanobody and diabody, having affinity or binding affinity against the Acinetobacter baumannii strain deficient in lipopolysaccharide (LPS) and/or against an outer membrane vesicle (OMV) derived therefrom. In a preferred embodiment, said antibody or fragment thereof specifically binds the Acinetobacter baumannii strain deficient in lipopolysaccharide (LPS) and/or to the outer membrane vesicle (OMV) derived therefrom.

[0025] "Affinity" or "binding affinity" KD are often determined by measurement of the equilibrium association constant (ka) and equilibrium dissociation constant (kd) and calculating the quotient of kd to ka (KD=kd/ka).

[0026] The term "specifically binding" means that the antibody binds to the LPS deficient strain or to the OMV derived therefrom with an affinity KD of lower than or equal to 10.sup.-6M (monovalent affinity). The antibody may have substantially greater affinity for the target antigen compared to other unrelated molecules. The antibody may also have substantially greater affinity for the target antigen compared to homologs, e.g. at least 1.5-fold, 2-fold, 5-fold 10-fold, 100-fold, 10.sup.-3-fold, 10.sup.-4-fold, 10.sup.-5-fold, 10.sup.-6-fold or greater relative affinity for the target antigen. Such affinities may be readily determined using conventional techniques, such as by equilibrium dialysis; by radioimmunoassay using radiolabeled target antigen; or by another method known to the skilled artisan. The affinity data may be analyzed, for example, by the method described in [Kaufman R J, Sharp P A. (1982) Amplification and expression of sequences cotransfected with a modular dihydrofolate reductase complementary dna gene. J Mol Biol. 159:601-621].

[0027] The term "antibody" is used in the broadest sense and includes fully assembled antibodies, monoclonal antibodies, polyclonal antibodies, multispecific antibodies (e.g., bispecific antibodies), antibody fragments that can bind the antigen (e.g., Fab', F'(ab)2, Fv, single chain antibodies, diabodies), camelbodies and recombinant peptides comprising the forgoing as long as they exhibit the desired biological activity.

[0028] A "functional fragment" or "antigen-binding antibody fragment" of an antibody/immunoglobulin hereby is defined as a fragment of an antibody/immunoglobulin (e.g., a variable region of an IgG) that retains the antigen-binding region. An "antigen-binding region" of an antibody typically is found in one or more hypervariable region(s) of an antibody, i.e., the CDR-1, -2, and/or -3 regions; however, the variable "framework" regions can also play an important role in antigen binding, such as by providing a scaffold for the CDRs.

[0029] The term "hypervariable" region refers to the amino acid residues of the variable domains VH and VL of an antibody or functional fragment which are responsible for antigen-binding.

[0030] Nonlimiting examples of antibody fragments include Fab, Fab', F(ab')2, Fv, domain antibody (dAb), complementarity determining region (CDR) fragments, single-chain antibodies (scFv), single chain antibody fragments, diabodies, triabodies, tetrabodies, minibodies, linear antibodies [Johnson G, Wu T T. (2000) Kabat database and its applications: 30 years after the first variability plot. Nucleic Acids Res. 28:214-218]; chelating recombinant antibodies, tribodies or bibodies, intrabodies, nanobodies, small modular immunopharmaceuticals (SMI Ps), an antigen-binding-domain immunoglobulin fusion protein, a camelized antibody, a VHH containing antibody, or muteins or derivatives thereof, and polypeptides that contain at least a portion of an immunoglobulin that is sufficient to confer specific antigen binding to the polypeptide, such as a CDR sequence, as long as the antibody retains the desired biological activity; and multispecific antibodies formed from antibody fragments [Chothia C, Lesk A M. (1987) Canonical structures for the hypervariable regions of immunoglobulins. J Mol Biol. 196:901-917; Zapata G, Ridgway J B, Mordenti J, Osaka G, Wong W L, Bennett G L, Carter P. (1995) Engineering linear F(ab')2 fragments for efficient production in Escherichia coli and enhanced antiproliferative activity. Protein Eng. 8:1057-1062].

[0031] In a preferred embodiment of aspect C of the invention, the pharmaceutical or vaccine composition is obtained or obtainable after immunizing a mammal with the vaccine composition as defined in the first aspect of the invention.

[0032] Aspect D:

[0033] This aspect of the invention refers to the vaccine composition as defined in aspect C of the invention, for use in the therapeutic treatment (after the infection), or in the passive immunization, of an infection caused by A. baumannii in a mammal, preferably in a human.

[0034] Aspect E:

[0035] This aspect of the invention refers to an Acinetobacter baumannii strain deficient in lipopolysaccharide (LPS), transformed, transduced or transfected with a nucleotide sequence capable of coding for any of the amino acid sequences as defined in aspect A of the invention so that such strain is capable of producing the exogenous expression any of said amino acid sequences. Preferably, said A. baumannii deficient strain is use as a medicament.

[0036] Aspect F:

[0037] This aspect of the invention refers to a method for the production of antibodies or fragments thereof, preferably selected from the list consisting of Fab, Fab', Fab'-SH, Fv, scFv, F(ab').sub.2, Vhh, nanobody and diabody, which comprises:

[0038] a. Selecting an antibody or a fragment thereof, preferably from an antibody library;

[0039] b. Using an Acinetobacter baumannii strain deficient in lipopolysaccharide (LPS) and/or an outer membrane vesicle (OMV) derived therefrom, as an antigenic target;

[0040] c. Selecting those antibodies or fragments thereof having affinity or binding affinity or capable of specifically binding such strain and/or OMV; and

[0041] d. Producing those antibodies or fragments thereof identified in step c) above

[0042] It is noted, that Serotype specific variability in A. baumannii relies on variations in epitopes of the LPS component. By eliminating the LPS component according to the method as detailed in aspect F above, we focus the antibody raising to antibodies against less variable epitopes of the bacterial surface, not related to the LPS component. These epitopes are conserved among A. baumannii strains or individual isolates belonging to all A. baumannii international clones used in A. baumannii classification. This method thus provides the tools for a universal treatment against A. baumannii infections independently of the origin of the strain(s) responsible for the host infection.

[0043] Aspect G:

[0044] This aspect of the invention refers to an antibody or fragment thereof produced, obtained or obtainable by the method of aspect F of the invention.

[0045] Aspect H:

[0046] This aspect of the invention refers to the use of an Acinetobacter baumannii strain deficient in lipopolysaccharide (LPS) and/or an outer membrane vesicle (OMV) derived therefrom, for the production of antibodies or fragments thereof having affinity or binding affinity or capable of specifically binding such strain and/or OMV.

DETAILED DESCRIPTION OF THE INVENTION

[0047] The present invention refers to compositions and vaccines that consist of whole cells deficient in LPS and/or outer membrane vesicles of Acientobacter baumannii (A. baumannii) capable of conferring protection against infection caused by infectious pathogens.

[0048] The authors of the present invention demonstrate that inactivated cells of A. baumannii deficient in LPS and/or outer membrane vesicles from A. baumannii, upon being inoculated produce immunization, which provides protection against posterior infection by said bacteria, which demonstrates the utility of these cells or strains as prophylactic vaccines against infections caused by A. baumannii.

[0049] A first aspect of the present invention refers to an Acinetobacter cell or strain that is deficient in LPS, hereinafter cell or strain of the invention.

[0050] The species of Acinetobacter are strictly aerobic non-fermenting and non-motile bacilli that are oxidase negative and appear in pairs by microscopy. They are distributed widely in nature, and are important in soil and contribute to its mineralization.

[0051] It is understood that "inactivated cell" in the present invention is a cell that does not have the ability to replicate but that conserves its immunogenic capacity. The cells of the present invention are inactivated prior to their inoculation to prevent their replication in the host, and therefore prevent invention produced by their administration. The inactivation of the cells of the invention can be performed using diverse methods known in the state of the art for example, although not limited to, adsorption, heat, ultraviolet light, ionizing radiation, ultrasound, phenol, formol, formaldehyde, crystal violet, glyceraldehyde, ethylene oxide, propiolactone, ethylenamina, bromoethyleneamina or formalin. In a preferred embodiment, the cells of the invention are inactivating with formalin. In another preferred embodiment the cells of the invention are from the species Acinetobacter baumannii and they are inactivated with formalin.

[0052] In a preferred embodiment of this aspect of the invention, the deficiency in LPS can be achieved by partial or compete inactivation of one or various cellular molecules of nucleic acids that encode the endogenous genes for the LPS subunits, particularly IpxA, IpxB and/or IpxC of LPS.

[0053] In another preferred embodiment of the invention, the cell or strain of Acinetobacter deficient in LPS is obtained by deletions and/or insertions of one or various nucleotides in nucleic acid sequences encoding the gene involved in the biosynthesis of LPS and/or the sequences that control their expression. The deletions and/or insertions can be generation by homologous recombination, insertion of transposons, or other adequate methods known in the state of the art.

[0054] In preferred embodiment of the invention, the sequence is inactivated e.g. by construction of a suicide vector that contains the gene IpxA, IpxB, IpxC, IpxD, IpxK, IpxL and/or IpxM or any of their combination, or interrupting with a marker gene for selection, transforming the target cells with the vector and screening for positive cells that are negative for LPS expression.

[0055] In another preferred embodiment of the invention, the cell or strain of the invention is preferably an A. baumannii cell, particularly an attenuated A. baumannii cell or other Acinetobacters; Acinetobacter baylyi, A. beijerinckii, A. bereziniae, A. boissieri, A. bouvetii, A. brisouii, A. calcoaceticus, A. gerneri, A. guillouiae, A. grimontii, A. gyllenbergii, A. haemolyticus, A. indicus, A. johnsonii, A. junii, A. lwoffii, A. nectaris, A. nosocomialis, A. parvus, A. pittii, A. puyangensis, A. radioresistens, A. rudis, A. schindleri, A. soli, A. tandoii, A. tjernbergiae, A. towneri, A. ursingii or A. venetianus.

[0056] In this report, it is understood that Acinetobacter refers to the kingdom Bacteria, phylum Proteobacteria, class Gammaproteobacteria, order Pseudomonadales, family Moraxellaceae.

[0057] It is understood that "cells or strains of the Acinetobacter baumannil" in the present invention are those cells pertaining to the domain Bacteria, phylum Proteobacteria, class Gammaproteobacteria, order Pseudomonadales, family Moraxellaceae, genus Acinetobacer, species Acinetobacter baumannii.

[0058] It is understood that "lipopolysaccharide (LPS) or lipooligosaccharide" is a component that is found on the external membrane of various Gram-negative bacteria. The term LPS is used often and interchangeably with "endotoxin", due to its history of discovery. LPS consists of a polysaccharide chain and the rest is lipid, known as lipid A, which is responsible for the endotoxin activity. The polysaccharide chain is variable between different bacterias and determines the serotype. Endotoxin is of approximately 10 kDa in size, but can form large aggregates of up to 1000 kDa. Humans are able to produce antibodies against LPS, but in general these antibodies can only protect against bacteria of a specific serotype. Endotoxin is responsible for many of the clinical manifestations of infections caused by Gram-negative bacteria such as Neisseria meningitidis and Acinetobacter baumannii.

[0059] Composition of the Invention

[0060] A second aspect of the invention refers to a composition, hereinafter composition of the invention comprising:

[0061] a) a cell or strain of the invention, and

[0062] b) optionally a sequence of nucleotides and/or amino acids or polypeptides.

[0063] In a more preferred embodiment of this aspect of the invention, the nucleic acid and/or the amino acid sequence or polypeptide is recombinant.

[0064] In a still more preferred embodiment, the polypeptide is selected from

[0065] I) the peptide sequence SEQ ID NO: 27 (putative ferric siderophore receptor (A. baumannii ATCC 17978; accession number YP_001084684)) or a fragment thereof, wherein the fragments are biologically active fragments, preferably selected from the list consisting of SEQ ID NO: 1 to SEQ ID NO: 11, or any of its combinations, or sequences having at least 85% sequence identity with the peptide sequences SEQ ID NO: 1 to SEQ ID NO: 11, and/or

[0066] II) the peptide sequence SEQ ID No 28 (putative ferric hydroximate siderophore receptor (A. baumannii ATCC 17978; accesion number YP_001084696)) or a fragment thereof, wherein the fragments are biologically active fragments, preferably selected from the list consisting of SEQ ID NO: 12 to SEQ ID NO: 23, or any of its combinations, or sequences having at least 85% sequence identity with the peptide sequences SEQ ID NO: 12 to SEQ ID NO: 23.

[0067] In a still more preferred embodiment, the composition of the invention comprises the amino acid sequence SEQ ID NO: 28 and the amino acid sequence SEQ ID NO: 27.

[0068] In another preferred embodiment, the composition of the invention comprises a fusion protein that consists of at least 2, preferably 3, more preferably 4, amino acid sequences from the following list consisting of: SEQ ID NO: 1 to SEQ ID NO: 23 or a variant of these sequences having at least 85% identity with the sequences SEQ ID NO: 1 to SEQ ID NO: 23.

[0069] In another preferred embodiment, the fusion protein comprises the amino acid sequence SEQ ID NO: 24 or the amino acid sequence SEQ ID NO: 25.

[0070] In another preferred embodiment, the composition of the invention comprises a nucleotide sequence, hereinafter nucleotide sequence of the invention, capable of transcribing an amino acid sequence described in the invention. More preferably, the nucleotide sequence is SEQ ID NO: 26.

[0071] The fragments described previously differ in amino acid sequence by at least one amino acid. The most preferred variations are those having at least 85%, or more, including 90%, 93% or more, and preferably 95% or more, 96% or more, 97% or more, 98% or more, 99% or more of sequence identity with any of the polypeptides shown in SEQ ID NO:1 to SEQ ID NO:25. More preferably, the invention refers to a sequence variant characterize by at least one (at least two, at least three, at least four) mutation(s) in relation to any of the polypeptides SEQ ID NO:1 to SEC ID NO:25. In agreement with the invention as described in the descriptive section, mutation can refer to any mutation selected by insertion(s), deletion(s), and substitution(s). Preferably substitution(s).

[0072] In another preferred embodiment, the composition of the invention comprises an expression vector (hereinafter expression vector of the invention), comprising a nucleotide sequence of the invention.

[0073] In another preferred embodiment, the composition of the invention also comprises outer membrane vesicles, hereinafter outer membrane vesicles of the invention, deficient in LPS.

[0074] In another preferred embodiment, the composition of the invention also comprises at least one or the proteins purified from the membrane of A. baumanni with amino acid sequence SEQ ID NO: 29, SEQ ID NO: 30, SEQ ID NO: 31, SEQ ID NO: 32, SEQ ID NO: 33, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 36, SEQ ID NO: 37, SEQ ID NO: 38, SEQ ID NO: 39, SEQ ID NO: 40, SEQ ID NO: 41, SEQ ID NO: 42, SEQ ID NO: 43, SEQ ID NO: 44, SEQ ID NO: 45, SEQ ID NO: 46; SEQ ID NO: 47; SEQ ID NO: 48; SEQ ID NO: 49; SEQ ID NO: 50; SEQ ID NO: 51; SEQ ID NO: 52; SEQ ID NO: 53; SEQ ID NO: 54; SEQ ID NO: 55; SEQ ID NO: 56; SEQ ID NO: 57; SEQ ID NO: 58; SEQ ID NO: 59; SEQ ID NO: 60; SEQ ID NO: 61; SEQ ID NO: 62; SEQ ID NO: 63; SEQ ID NO: 64; SEQ ID NO: 65; SEQ ID NO: 66; SEQ ID NO: 67; SEQ ID NO: 68; SEQ ID NO: 69; SEQ ID NO: 70; SEQ ID NO: 71; SEQ ID NO: 72; SEQ ID NO: 73; SEQ ID NO: 74; SEQ ID NO: 75; SEQ ID NO: 76, SEQ ID NO: 77, SEQ ID NO: 78, SEQ ID NO: 79, SEQ ID NO: 80, SEQ ID NO: 81, SEQ ID NO: 82, SEQ ID NO: 83, SEQ ID NO: 84, SEQ ID NO: 85, SEQ ID NO: 86, SEQ ID NO: 87, SEQ ID NO: 88, y SEQ ID NO: 89, or any of their combinations.

[0075] More preferably, at least one of the proteins of the outer membrane of A. baumannii is obtained by a process comprising:

[0076] a. Inoculating one liter of Mueller-Hinton broth with a colony of A. baumannii ATCC 19606;

[0077] b. incubating the culture until an optical density of 0.6 at 600 nm;

[0078] c. Washing bacterial cells with 30 ml of 10 mM phosphate buffer pH, 7.2;

[0079] d. Centrifuge at 6000.times.g for 10 min;

[0080] e. Resuspend the bacterial pellet sin 10 ml of 10 mM phosphate buffer pH 7.2 and lysing by sonication 5 times for 1 minute;

[0081] f. Eliminate unlysed cells by centrifugation at 6000.times.g for 5 minutes;

[0082] g. Centrifuge the supernatant at 4.degree. C. at 20000.times.g for one hour;

[0083] h. Eliminate proteins of the external membrane by solubilising with 5 ml of 2% N-lauraylsarcosinante in 10 mM phosphate buffer pH 7.2 for 30 minutes at 37.degree. C.;

[0084] i. Precipitate the insolube fraction (that contains the outer membrane proteins) by centrifuging at 4.degree. C. at 20000.times.g for one hour;

[0085] j. Wash the pellet once with 2 ml 62.5 mM Tric-HCl ph, 6.8 and centrifuge at 4.degree. C. for one hour;

[0086] k. Resuspend the pellet in a solution of 5% SDS and precipitate with methanol/chloroform; and

[0087] l. Resuspend the pellet in sterile PBS.

[0088] In another preferred embodiment of the invention, the composition of the invention is a pharmaceutical composition, more preferably also comprises an acceptable pharmaceutical vehicle, and still more preferably, also comprises another active ingredient.

[0089] In another preferred embodiment, the composition of the invention also comprises an adjuvant. In another preferred embodiment, the composition of the invention is a vaccine.

[0090] In the context of the present invention, the term "vaccine" refers to an antigenic preparation employed for inducing an immune response to a disease. They are prepared from antigens that, once inside the host, provoke an immune response through the production of antibodies, and generate immunologic memory producing transient or permanent immunity. It is noted that as used herein the term "vaccine" can also be understood as a preparation from antibodies or fragments thereof suitable for the therapeutic treatment or for passive immunization of an infection caused by an Acinetobacter strains, in particular from an A. baumannii strain.

[0091] Nucleotide Sequence and Expression Vector

[0092] A third aspect of the invention refers to a nucleotide sequence, hereinafter second nucleotide sequence of the invention, which encodes any of SEQ ID NO 1 to 25, 27 or 28 or any combination thereof. Said second nucleotide sequence of the invention also includes nucleic acid sequence SEQ ID NO: 26.

[0093] A fourth aspect of the invention refers to an expression vector, hereinafter expression vector of the invention, comprising the second nucleotide sequence of the invention.

[0094] In a preferred embodiment of this aspect, the cell of the invention comprises the expression vector of the invention.

[0095] The nucleic acid can be localized in a recombinant vector. Preferably, the recombinant vector is a prokaryotic vector, that is a vector that contains elements for replication and/or integration into the genome of prokaryotic cells. Preferably, the recombinant vector contains the nucleic acid molecule of the present invention operatively linked to an expression control sequence. The control sequence is preferably a sequence controlling the active expression in Acinetobacter, particularly in A. baumannii. The vector can be an extrachromosomic vector adequate for integration in the chromosome. Examples of such as vectors are known by experts in the field, for example in Sambrook et al. supra.

[0096] Outer Membrane Vesicles of the Invention A fifth aspect of the invention refers to an outer membrane vesicle that is deficient in LPS. In a preferred embodiment of this aspect, the outer membrane vesicle is obtained from the cell or strain of the invention.

[0097] Use of the Cells, Vesicles and the Compositions of the Invention

[0098] A sixth aspect refers to the composition of the invention for use as a medicament, or alternatively, to the use of the composition of the invention for the manufacture of a medicament.

[0099] The term "medicament" or "pharmaceutical composition" as used in this report, makes reference to any substance used for the prevention, alleviation, treatment or cure of a disease in man or animals. The context of the present invention refers to a composition comprising the composition of the invention. This composition of the invention comprises inactivated cells of the genus Acinetobacter and/or outer membrane vesicles of the same in a quantity therapeutically effective, that is able to inducer an immune response in the organism in which they are administered against an organism of the genus Acinetobacter. The term "medicament" or "pharmaceutical composition" therefore is known as a vaccine.

[0100] The dosing for obtaining the effective therapeutic quantity depends on a variety of factors such as for example, age, weight, sex, tolerante, . . . of the mammal. As used in this description, the "effective therapeutic quantity" refers to the quantity of inactive cells of the genus Acinetobacter and/or outer membrane vesicles that produce the desired effect, and in general are determined by the therapeutic effect that is desired.

[0101] A seventh aspect of the invention refers to the composition of the invention for the prevention, the improvement or the treatment of an infection caused by A. baumannii, en a mammal, or alternatively, to the use of the composition of the invention for the elaboration of a medicament for the prevention, improvement or treatment of an infection caused by A. baumannii in a mammal.

[0102] It is understood by "disease produced by organisms of the genus Acientobacter" those diseases in which the causal agent of the pathology is from the genus Acinetobacter, or any of its metabolic products. The genus Acinetobacter produces diverse pathologies for example but not limited to, bacteremia, meningitis, urinary tract infections, skin and soft tissue infections, surgical site infections and pneumonia. For these reasons, one of the more preferred forms, diseases produced by organisms of the genus Acinetobacter are selected from a list that consists of bacteremia, meningitis, urinary tract infections, skin and soft tissue infections, surgical site infections and pneumonia.

[0103] The medicaments and compositions of the invention can be used alone or in combination with other medicaments or compositions for the treatment of diseases produced by organisms from the genus Acinetobacter.

[0104] Both the medicaments and the compositions of the invention can also include pharmaceutically acceptable vehicles or excipients

[0105] The medicaments and compositions of the invention may be used either alone or in combination with other medicaments or compositions for the treatment or prevention of diseases caused by organisms of the genus Acinetobacter.

[0106] The term "excipient" makes reference to a substance that helps in the absorption of the elements of the composition of the medicaments of the invention, stabilizing said elements, activating or helping the preparation of the medicament such that it provides consistency or flavours that make it more palatable. The excipients can maintain the ingredients together, like for example is the case with starches, sugars, cellulose, sweetners, coloring agents, the function of protecting the medicament, for example isolating it form air and/or humidity, the function of filling the pill, capsule or any other form of presentation, for example, the case of dibasic calcium phosphate, the function for facilitating dissolution of the components and their absorption in the intestine, without excluding other types of excipients described in this paragraph.

[0107] The vehicle, in the same way as the excipient, is a substance that is used in the medicament to dilute any of the components of the present invention to a desired volume or weight. The pharmaceutically acceptable vehicle is an inert substance or of similar action to any of the elements of the present invention.

[0108] The function of the vehicle is to facilitate the incorporation of other elements, permit better dosing and administration and give consistency and form to the medicament. When the form of presentation is liquid, the pharmaceutically acceptable vehicle is the diluent.

[0109] The adjuvants and pharmaceutically acceptable vehicle that can be used in the composition of the invention are those vehicles known by experts in the field.

[0110] In this report, the term "adjuvant" refers to any agent that does not poses antigenic activity in and of itself, that can be used to stimulate the immune system to increase the response to a vaccine. There are many adjuvants, for example but not limited to, aluminium phosphate, aluminium hydroxide, toll-like receptor agonists, cytokines, squaline, Freunds incomplete and complete adjuvants. In a preferred form of this aspect of the invention, the adjuvant is selected for a list that consists of aluminium phosphate, aluminium hydroxide, toll-like receptor agonists, cytokines, squaline, Freunds incomplete and complete adjuvants. In a still more preferred form of this aspect of the invention, the adjuvant is aluminium phosphate.

[0111] As used here, the term "active ingredient", "active substance" or "pharmaceutically active substance" or "pharmaceutically active ingredient" refers to any component that potentially provides pharmacological activity or other different effect in the diagnosis, cure, alleviation, treatment or prevention of a disease or that affects the structure or function of the human or animal body. The term includes those components that promote a chemical change in the elaboration of the drug and are present in the same and a modified form that provides specific activity or the effect.

[0112] An eighth aspect of the invention refers to the composition of the invention for conferring protection against an infection caused by A. baumannii en a mammal, or alternatively, the use of the composition of the invention in the elaboration of a medicament for conferring protection against an infection caused by A. baumannii in a mammal.

[0113] Another aspect of the invention refers to the fusion protein or peptide of the invention or the composition of the first or second aspect of the invention or the pharmaceutical composition of the invention that can be administered once or various, such as two, three, four, five, six, seven, eight, nine or ten or more times. There are no particular limitations relative to the quantity of the active ingredient per dose.

[0114] An additional aspect of the present invention refers to a composition that consists o fan antibody or fragment thereof that is capable of binding to SEQ ID NO: 27 or SEQ ID NO: 28 or a fusion protein as defined in the second aspect or the fusion protein of the invention, wherein preferably said composition is a pharmaceutical composition, preferably a vaccine, and wherein said pharmaceutical composition is used in the treatment or prevention of an infection caused by A. baumannii.

[0115] A ninth aspect of the invention refers to an antibody or an active fragment thereof obtainable by immunization of a mammal with the composition of the first or second aspect of the invention or with the fusion protein of the invention, preferably said antibody or active fragment consists of a composition in which preferably said composition is a pharmaceutical composition and said pharmaceutical composition is used as a therapy, particularly for the treatment of infections caused by A. baumannii.

[0116] Method for Preparing an Acinetobacter Cell Following the Invention

[0117] A tenth aspect of the invention refers to a method for preparing a cell of A. baumannii as described above.

[0118] Acinetobacter

[0119] In agreement with this aspect, this method consists of the steps to (i) provide a bacterial cell deficient in LPS, particularly a cell of Acinetobacter, (ii) insert a recombinant nucleic acid molecule in said bacterial cell, encoding said nucleic acid molecule a fusion peptide that consists of (a) at least on domain of the polypeptide wherein said domain is capable of producing an immune response in mammal and (b) a domain of escape for the phagolysosome, and (iii) culture the obtained cell in agreement with step (ii) in adequate conditions. Preferably, a cell capable of expressing said nucleic acid is obtained. More preferably, the cell is a cell of A. baumannii.

[0120] In agreement with the additional aspect, this method consists of step of (i) providing a bacterial cell deficient in LPS, particularly an Acinetobacter cell, (ii) inserting a recombinant nucleic acid molecule in said bacteria, encoding said nucleic acid molecule a peptide or polypeptide for escape from the phagolysosome, and (iii) culture the obtained cell in agreement with step (ii) in adequate conditions.

[0121] If desired, the method of the present invention consists of inserting at least one recombinant nucleic acid molecule in the bacterial cell, said molecule encoding a peptide or polypeptide capable of producing an immune response in mammals.

[0122] It is understood that "infection" in the present invention is that pathology generated by the invasion or colonization of any host tissue by any organisms of the genus Acinetobacter, preferably Acinetobacter baumannii.

[0123] It is understood that "soft tissue" in the present invention, is all non-bony tissue of an organism.

[0124] The term "prevention" as understood in the present invention consists of avoiding the appearance of damage whose cause is cells of the genus Acinetobacter, or any derivative or metabolic product of the same.

[0125] The term "antigen" in the report refers to a molecule (generally a protein or polysaccharide) that can induce the formation of antibodies. There many different types of molecules that can act as antigens, such as proteins, peptides, polysaccharides, and more rarely other molecules such as nucleic acids.

[0126] The term "resistance" refers to any mechanism of defense developed by bacteria against a drug. The mechanisms of resistance acquired and transmitted by bacteria are the most important and consist primarily of: the production of enzymes that inactivate antibiotics, appearance of modifications that impede the arrival of the drug to its target and/or alteration of the target itself. One bacterial strain can develop various resistance mechanisms against one or many antibiotics and in the same way an antibiotic can be inactivated by distinct mechanisms from diverse bacterial species.

[0127] The terms "polynucleotide" and "nucleic acid" are used interchangeably, referring to polymeric forms of nucleotides of any length, both of DNA and RNA

[0128] The terms "amino acid sequence", "peptide", "oligopeptide", "polypeptide" and "protein" are used interchangeably, and refer to a polymeric form of amino acids of any length that can be chemically or biochemically modified.

[0129] During the description of the claims, the word "comprising" and its variants does not intend to exclude other technical characteristics, additives, components or steps. For those expert in the state of the art, other objects, advantages and characteristics of the invention are released in the section of the description and practice of the invention. The following examples and drawings are provided as illustrations, and are not intended to limit the present invention.

DESCRIPTION OF THE FIGURES

[0130] FIG. 1. Stability and endotoxin content of IB010. (A) Genomic DNA from three independent cultures of ATCC 19606 and IB010 was extracted and amplified using primers specific for the IpxD gene. The band corresponding to approximately 1000 Kb corresponds to the intact IpxD gene, whereas the faster migrating band corresponds to the IpxD gene with a deletion of 462 nucleotides. (B) Endotoxin levels of ATCC 19606 and IB010 determined by the Limulus Amebocyte Assay. Bars represent the median values of three independent cultures, and error bars represent the standard error of the mean. EU; endotoxin units.

[0131] FIG. 2. Antibody response to immunization with IB010. Serum samples were collected from ATCC 19606 vaccinated, IB010 vaccinated and control mice before vaccination (Day 0) and at day 7 and 21 after the first immunization, and levels of antigen specific total IgG (A) and IgM (B) were measured by ELISA (n=8 mice/group). IgG1 (C) and IgG2c (D) levels were measured in 21-day serum were measured by ELISA in ATCC 19606 vaccinated, IB010 vaccinated and control mice. In all panels box and whisker plots represent the interquartile ranges and ranges, respectively, and horizontal lines represent median values. * p<0.05 compared to levels in control mice at the same time point, # p<0.05 compared to 7-day samples from the same experimental group, .dagger. p<0.05 compared to 21-day samples in ATCC 19606 vaccinated mice.

[0132] FIG. 3. Effect of vaccination on tissue bacterial loads. Immunized and control mice were infected with 2.0.times.10.sup.6 cfu (300.times.LD.sub.50) of the ATCC 19606 strain and spleen bacterial loads were determined 12 hours post-infection (n=8 mice/group). Data points represent bacterial loads from individual mice, and horizontal lines represent median values from groups of mice. * p<0.05 compared to control mice.

[0133] FIG. 4. Effect of vaccination on post-infection pro-inflammatory cytokine levels. Immunized and control mice were infected with 2.0.times.10.sup.6 cfu (300.times.LD.sub.50) of the ATCC 19606 strain and serum levels of IL-1.beta., TNF-.alpha., and IL-6 were determined (n=8 mice/group). Data points represent cytokine levels from individual mice, and horizontal lines represent median values from groups of mice. * p<0.05 compared to control mice, # p<0.05 compared to ATCC 19606 vaccinated mice.

[0134] FIG. 5. Effect of vaccination on survival in a mouse model of disseminated A. baumannii infection. Vaccinated and control mice were infected with 2.25.times.10.sup.6 cfu (340.9.times.LD.sub.50) of the ATCC 19606 strain (A) or 1.05.times.10.sup.6 cfu (2.18.times.LD.sub.50) of the A. baumannii clinical isolate Ab-154 (B), and survival was monitored over the following 7 days (n=8 mice/group). * p<0.05 compared to control mice.

[0135] FIG. 6. Protein profile of the A. baumannii OMVs without LPS. The strains ATCC 19606 and IB010 for the production of OMVs after culturing 24, 48 and 72 hours. After the purification of OMVs the amount of protein was quantified using Bradford method and 10 mcg of the protein was visualized in a 10% polyacrylamide gel with Coomassie stain.

[0136] FIG. 7. Effect of 2,2 Bipyridyl, iron chelator, in the protein profile of OMVs. The strains ATCC 19606 and IB010 were used to analyze the effect of 2,2 bypiridyl (BIP) on the protein profile of the OMVs after culturing for 24 hours. In the case of the ATCC 19606 strain a concentration of 200 mcM was used while in the case of IB010 100 and 150 mcM was used. After the purification of OMVs the amount of protein was quantified using Bradford method and 10 mcg of the protein was visualized in a 10% polyacrylamide gel with Coomassie stain.

[0137] FIG. 8. Effect of 2,2 Bipyridyl, iron chelator, on the production of OMVs. The strains ATCC 19606 and IB010 were used to analyze the effect of 2,2 bypiridyl (BIP) on the production of the OMVs after culturing for 24 hours. In the figure the total protein content of the OMVs is shown after treatment with Bip and measuring the concentration with Bradford.

[0138] FIG. 9. Visualization of OMVs. OMVs purified form ATCC 19606 were fixed using glutaraldehyde at 1.6% and stained with osmium tetroxide and lead and uranium and visualized by electron microscopy.

[0139] FIG. 10. Visualization of purified OMVs. OMVs purified form IB010 were fixed using glutaraldehyde at 1.6% and stained with osmium tetroxide and lead and uranium and visualized by electron microscopy.

[0140] FIG. 11. Protein profile of OMVs without LPS. The strains IB010 and 167R were used to produce OMVs and the amount of protein was quantified from each sample. Ten mcg of the protein was visualized in a 10% polyacrylamide gel with Coomassie stain.

EXAMPLES OF THE INVENTION

Example 1

Ethics Statement

[0141] All experiments involving the use of animals were approved by the University Hospital Virgen del Rock) Committee on Ethics and Experimentation (Evaluation code: 2013PI/296). In all experiments, efforts were made to minimize suffering, and any animals appearing moribund during the course of experimentation were immediately euthanized using thiopental.

[0142] Bacterial Strains.

[0143] A. baumannii ATCC 19606 is an antibiotic susceptible reference strain. An LPS-deficient derivative of ATCC 19606 was obtained by plating an overnight culture of ATCC 19606 on Mueller Hinton agar containing 10 mg/I of colistin, as described previously (Clinical Laboratory Standards Institute 2013) Strains with mutations in the genes involved in LPS biosynthesis were identified by sequencing the IpxA, IpxC and IpxD genes of the colistin resistant mutants that were present after overnight growth at 37.degree. C. A strain with a large deletion in the IpxD gene was identified and designated IB010. Resistance to colistin was confirmed by broth microdilution according to Clinical Laboratory Standard Institute guidelines [23]. Absence of LPS was confirmed by measuring the endotoxin levels of three independent cultures of each strain using the QCL-1000 Limulus Amebocyte Assay (Lonza) according to the manufacturer's instructions. The Ab-154 strain is a previously characterized A. baumannii clinical isolate (Gautom, 1997. J. Clin. Microbiol. 35, 2977-2980).

[0144] Vaccine Preparation and Mouse Immunization.

[0145] The IWC vaccines (both LPS-containing and LPS-deficient) were prepared as described based on a previously described method (Moffatt et al., 2010. Antimicrob. Agents Chemother. 54, 4971-4977). Briefly, the ATCC 19606 and IB010 strains were grown in Mueller-Hinton broth to OD.sub.600 of 0.8. In the case of IB010, 10 .mu.g/ml of colistin were added to the culture. In order to confirm that no reversion to wild type occurred during growth of IB010, three independent cultures of ATCC 19606 and IB010 were grown, and genomic DNA was isolated from each culture using the QIAmp DNA Mini Kit (Qiagen). The IpxD specific primers 5' GCTAATTGGTGAAGGTAGTC 3' and 5' GACGAATCGTTTGAATCTGC 3' were used to amplify genomic DNA from the cultures in order to confirm that the deletion in IpxD of IB010 was present after growth.

[0146] For vaccine preparation, bacteria were washed extensively in phosphate buffer saline before inactivation in 0.5 M formalin for 18 h with shaking at room temperature. Complete inactivation of the bacteria was confirmed by plating on blood agar. The concentration of inactivated cells was adjusted to 1.times.10.sup.10 cells/ml and combined 1:1 (v/v) with the aluminium-based adjuvant, Alhydrogel 2% (w/v) (InvivoGen). Vaccination was carried out in 6 to 8-week-old, female C57BL/6 mice by intramuscular injection of 100 .mu.l of the vaccine into each quadriceps muscle on days 0 and 14. Control mice were injected similarly with a mixture of phosphate buffer saline and adjuvant.

[0147] Mouse Model of A. baumannii Infection.

[0148] A mouse model of sepsis previously developed by our group and used for the evaluation of vaccines against A. baumannii was used to characterize the efficacy of the (Batson et al., 1950. J. Exp. Med. 91, 219-229; Rodriguez-Hernandez et al., 2000. J. Antimicrob. Chemother. 45, 493-501). This model produces a disseminated infection after intraperitoneal instillation of the inoculum, typically resulting in death within 24 to 48 hours. For preparation of the inocula, A. baumannii strains were grown for 18 h at 37.degree. C. in Mueller-Hinton broth cultures and adjusted to the appropriated concentration in physiological saline as described previously (Moffatt et al., 2010. Antimicrob. Agents Chemother. 54, 4971-4977; Martin et al., 1998. J. Immunol. Methods 212, 187-192). Bacterial concentrations of the inocula were determined by plating on blood agar. Mice were infected on day 21 (one week after the second immunization) by intraperitoneal injection with 0.5 ml of the bacterial suspension and survival was monitored for 7 days.

[0149] Spleen Bacterial Loads and Serum Cytokine Levels.

[0150] Post-infection bacterial loads were determined in vaccinated and control mice 12 h after infection. Mice were euthanized with an overdose of thiopental and after collection of blood samples from the retro-orbital sinus, spleens were aseptically removed, weighed and homogenized in 2 ml of physiological saline. Serial log dilutions were plated on blood agar plates for bacterial quantification. Serum levels of interleukin-1.beta.(IL-1.beta.), tumor necrosis factor alpha (TNF-.alpha.), and interleukin-6 (IL-6) were determined in mice at 12 h post-infection using BD OptEIA mouse kits (BD Biosciences).

[0151] Enzyme-Linked Immunosorbent Assays (ELISAs).

[0152] For indirect enzyme-linked immunosorbent assays (ELISAs), 96-well plates were coated with 5.times.10.sup.7 bacterial cells/well in phosphate buffer saline by incubating at 4.degree. C. overnight. ELISAs were performed using sera collected on days 0, 7 and 21 as described previously [28]. Antibody titers were measured against the strain which was used to immunize the mouse, and were defined as the dilution in which spectrophotometric readings were at least 0.1 units above background wells (wells containing no serum).

[0153] Statistical Analysis.

[0154] Antibody titers, bacterial loads, and cytokine levels were compared using the Kruskal-Wallis H test and the Mann-Whitney U test for independent samples, and the Friedmann and Wilcoxon tests for dependent samples. The Bonferroni correction was applied when appropriate. Survival data were compared using the log-rank test. All statistics were performed using SPSS version 15.0 software (SPSS Inc.), and a p value of 0.05 was considered significant.

[0155] Results

[0156] Selection of an LPS-Deficient Strain for Vaccine Development.

[0157] Growth of ATCC 19606 in the presence of 10 .mu.g/ml colistin resulted in numerous colistin-resistant derivatives with mutations in the IpxA, IpxC and IpxD genes (data not shown). One of these strains, IB010, contained a large deletion of 462 nucleotides in the IpxD (nucleotides 104-565) gene and was chosen for further use in vaccine studies. We reasoned that on the basis that the strain contained a large deletion, this strain would be less likely to revert to wild type during growth than strains containing single nucleotide changes or small deletions in the LPS biosynthesis genes. Broth microdilution experiments demonstrated that the minimum inhibitory concentration of the ATCC 19606 strain was 0.25 .mu.g/ml and >128 .mu.g/ml for IB010, demonstrating that, similar to results described previously, mutations in IpxD can result in resistance to colistin (Moffatt et al., 2010. Antimicrob. Agents Chemother. 54, 4971-4977). In order to ensure that the IB010 was genetically stable during growth, genomic DNA from three independent cultures of ATCC 19606 and IB010 were amplified with IpxD-specific primers to confirm that the deletion was present. As shown in FIG. 1A, a band corresponding to the mutated IpxD gene of IB010 containing a deletion of 462 nucleotides was present after amplification from all IB010 cultures indicating that no reversion had occurred. Phenotypic loss of LPS and reduction in endotoxin levels were characterized by the Limulus Amebocyte Assay for ATCC 19606 and IB010, and demonstrated that mutation in the IpxD gene resulted in a dramatic reduction in endotoxin levels to >1 EU per 10.sup.6 cells (FIG. 1B).

[0158] Antibody Response to the LPS-Deficient IWC Vaccine.

[0159] Formalin treatment of ATCC 19606 and IB010 resulted in no viable bacteria, indicating complete bacterial inactivation. In order to quantify the antibody response produced by immunization with inactivated IB010, indirect ELISAs were performed using sera collected from negative control mice (immunized with PBS and adjuvant) and mice vaccinated with 1.times.10.sup.9 inactivated IB010 cells. As a positive control, one group of mice was immunized with 1.times.10.sup.9 inactivated ATCC 19606 cells on the basis that we have previously shown that immunization with these cells induces a robust immune response and produces protective immunity against experimental infection (McConnell y Pachon, 2010. Vaccine 29, 1-5). As shown in FIG. 2A, immunization with inactivated IB010 elicited detectable levels of antigen-specific total IgG in all mice seven days after a single intramuscular administration, and these antibody levels were significantly increased upon boosting with a second administration of the vaccine (p=0.03 Wilcoxon test). Total IgG titers in mice receiving two administrations of inactivated IB010 vaccine were similar to titers in mice receiving the vaccine containing inactivated wild type cells (p=0.726 Mann Whitney U test). Control mice had no detectable antigen-specific IgG at any point. In contrast, IgM levels were similar between mice immunized with the inactivated IB010 vaccine and mice receiving inactivated wild type cells seven days after a single administration (p=0.186 Mann Whitney U test), however seven days after a second immunization there was no detectable antigen-specific IgM in 16010-vaccinated mice whereas all mice immunized with inactivated wild type cells had detectable levels of IgM (FIG. 2B).

[0160] Levels of the IgG subtypes IgG1 and IgG2c, the IgG2a homolog in C57BL/6 (Martin et al., 1998. J. Immunol. Methods 212: 187-192), were determined in 21-day serum (FIGS. 2C and D). Both groups of mice receiving the inactivated vaccines had significant levels of IgG1 and IgG2c compared to control mice (p<0.001; Mann-Whitney U test). Interestingly, IgG1 titers were significantly higher in IB010-vaccinated mice compared to ATCC 19606-vaccinated mice (p=0.003; Mann-Whitney U test), whereas IgG2c titers were similar between these groups. These results indicate that both Th1 and Th2 responses are elicited by the inactivated IB010 vaccine similar to what was previously shown for the inactivated ATCC 19606 vaccine (McConnell y Pachon, 2010. Vaccine 29, 1-5).

[0161] Effect of Vaccination on Post-Infection Bacterial Loads.

[0162] In order to characterize the effect of vaccination on post-infection tissue bacterial loads, we employed a mouse model previously developed by our group for the characterization of vaccine for preventing infection by A. baumannii (McConnell et al., 2011. Infect. Immun. 79, 518-526; McConnell et al., 2011. Vaccine 29: 5705-5710; McConnell y Pachon, 2010. Vaccine 29, 1-5). This model rapidly produces a disseminated infection in which bacteria are detected in distal organs as soon as one hour post-infection [16]. Vaccinated and control mice were infected with 2.0.times.10.sup.6 cfu (300.times.LD.sub.50) of the ATCC 19606 strain, and 12 hours after infection spleen bacterial loads were determined (FIG. 3). IB010 vaccination reduced the number of bacteria in spleens approximately 1000-fold compared to control mice (p<0.05; Mann-Whitney U test). Spleen bacterial loads in IB010 vaccinated mice were not significantly different than in mice immunized with inactivated ATCC 19606 cells.

[0163] Effect of Vaccination on Post-Infection Serum Cytokine Levels and Survival.

[0164] In order to characterize the effect of immunization with the inactivated LPS deficient vaccine on cytokine levels, sera were collected from vaccinated and control mice 12 h post-infection and the levels of IL-1.beta., IL-6 and TNF-.alpha. were determined (FIG. 4). Levels of all three cytokines were significantly lower in both groups of vaccinated mice than in control mice (p=0.003 for IL-1.beta., IL-6 and TNF-.alpha.; Mann-Whitney U test), suggesting that vaccinated mice did not experience the pro-inflammatory cytokine release associated with the development of septic shock.

[0165] Vaccine efficacy was tested by infecting immunized and control mice with 2.25.times.10.sup.6 cfu (340.9.times.LD.sub.50) of the ATCC 19606 strain seven days after the second immunization, and survival was monitored over seven days (FIG. 5). All mice vaccinated with the IB010 vaccine were protected from challenge, whereas all control mice died within 48 hours (P<0.001; log-rank test). As expected, all mice immunized with the ATCC 19606 strain survived challenge, similar to results that were previously reported (McConnell et al., 2011. Infect. Immun. 79, 518-526; McConnell et al., 2011. Vaccine 29: 5705-5710; McConnell y Pachon, 2010. Vaccine 29, 1-5). In order to determine if vaccination with IB010 could protect against heterologous challenge with an unrelated strain, immunized and control mice were infected with 1.05.times.10.sup.6 cfu (2.18.times.LD.sub.50) of the previously characterized A. baumannii clinical isolate Ab-154 [29]. Once again, all immunized mice survived challenge whereas control mice succumbed to infection within 48 hours (p<0.001; log-rank test), indicating that immunization with IB010 can provide cross protection against challenge with a heterologous strain.

[0166] In conclusion, these results provide important information regarding the development of a vaccine for the prevention of infections caused by A. baumannii based on whole bacterial cells lacking LPS. These results may also provide insights into the possibility of developing vaccines for other bacterial species based on strains lacking LPS.

Example 2

[0167] This example relates to the development of a vaccine against A. baumannii based on OMVS purified from said cultures of mutants without LPS.

[0168] To carry out this objective, the strains ATCC 19606T and its mutant without LPS IB010, which was generated in our laboratory from the ATCC 19606T strain and contains a deletion of 462 nucleotides between positions 103 and 565 of the gene IpxD.

[0169] Upon realizing the purification of the OMVs of said strains the following protocol was used:

[0170] Strains are refreshed on blood agar or MHBII plates with colistin at 10 mcg/ml and grown overnight at 37.degree. C.

[0171] A liquid culture is used to growth ATCC 19606 or IB010. They are cultured with aeration at 180 rpm at 37.degree. C. overnight.

[0172] The next day cultures of 50 or 100 ml or 1 L in MHB are made and incubated overnight at 37.degree. C. with aeration (180 rpm)

[0173] After incubation, the cells are centrifuged at 4000 rpm during 30 min at 4.degree. C.

[0174] Next, the supernatant is filtered with a 0.22 micron filter.

[0175] Afterwards, the OMVs are precipitated by ultracentrifugation for 90 minutes at 30000 rpm at 4.degree. C.

[0176] Finally, the pellet is resuspended in PBS and the absence of viable bacteria is confirmed by plating. The OMVs are stored at -80.degree. C.

[0177] (Protocol adapted from McConnell M J et al. 2011 Aug. 5; 29(34):5705-10)

[0178] Using the previous protocol different purifications of OMVs have been performed.

[0179] Purifications of OMVs of the strains ATCC 19606 and IB010 for the production of OMVs after culturing 24, 48 and 72 hours. After the purification of OMVs the amount of protein was quantified using Bradford method and 10 mcg of the protein was visualized in a 10% polyacrylamide gel with Coomassie stain.

[0180] In addition, purification have been performed with OMVs from the strain ATCC 19606 and IB010 in the presence and absence of Bip, which is an iron chelator, with the objective of verifying if the presence of the chelator resulted in the increased expression of proteins related with iron metabolism, for example, siderophore receptors. In this case, OMVs were purified for the quantification of proteins and for Coomassie staining of acrylamide gels and for the visualization of OMVs by electron microscopy.

[0181] Finally, OMVs were purified form the LPS mutant of a clinical isolate of A. baumannii Ab-167 which contains an ISAba1 insertion in the IpxC gene. Proteins were quantified and visualized on acrylamide gels by Coomassie staining. And proteins were quantified by Bradford and 2D Quant kit.

Example 3

Purification of Outer Membrane Proteins

[0182] A. baumannii ATCC 19606 was grown in 1 liter of Mueller-Hinton broth to an optical density at 600 nm (OD600) of 0.6, and pelleted bacteria were resuspended in 10 ml of 10 mM phosphate buffer, pH 7.2, and lysed by sonication. Unlysed cells were removed by centrifugation at 4,000.times.g for 5 min, and the supernatant was centrifuged at 20,000_g for 1 h to pellet cell envelopes. Inner membranes were selectively solubilized with 5 ml of 2% N-laurylsarcosinateby incubation at 37.degree. C. for 30 min. The insoluble fraction was pelleted by centrifugation at 20,000_g for 1 h and then washed with 2 ml of 62.5 mM Tris-Cl, pH 6.8.

[0183] Endotoxin was extracted from the preparation by use of a cold detergent wash step in which proteins were resuspended in 5% SDS and incubated at 4.degree. C. for 10 min. SDS and endotoxin were subsequently removed by precipitating in methanol chloroform and resuspended in PBS.

[0184] Addition of the Adjuvant

[0185] The purified proteins at a concentration of 500 mcg/ml were mixed with aluminum phosphate adjuvant at a 1:1 ration.

[0186] Clauses

[0187] 1. An Acinetobacter cell deficient in LPS.

[0188] 2. The Acinetobacter cell according to the preceding claim, obtained through partial or complete inactivation of one or various of the nucleic acids encoding the endogenous LPS biosynthesis genes.

[0189] 3. The Acinetobacter cell according to the preceding claim, wherein the genes are selected from IpxA, IpxB and/or IpxC, or any combination thereof.

[0190] 4. The Acinetobacter cell according to any one of the preceding claims, wherein the cell is obtained by deletions, and/or insertions of one or various nucleotides in the coding sequences of the genes.

[0191] 5. The Acinetobacter cell according to any one of the preceding claims, wherein the cell is an attenuated Acinetobacter cell.

[0192] 6. A composition comprising:

[0193] a) a cell according to any one of claims 1-2, and

[0194] b) a nucleic acid molecule, and/or a polypeptide.

[0195] 7. The composition according to the preceding claim, wherein the nucleic acid molecule is recombinant and the polypeptide is recombinant.

[0196] 8. The composition according to any one of claims 6-7, wherein the polypeptide is selected from:

[0197] a) the peptide sequence SEQ ID NO: 27 (putative ferric siderophore receptor (A. baumannii ATCC 17978; accession number YP_001084684)) or a fragment thereof, wherein the fragments are biologically active fragments, and preferably selected from the list consisting of SEQ ID NO: 1 to SEQ ID NO: 11, or any of its combinations, or sequences having at least 85% sequence identity with peptide sequences SEQ ID NO: 1 to SEQ ID NO: 11, and/or

[0198] b) the peptide sequence SEQ ID NO: 28 (putative ferric hydroximate siderophore receptor (A. baumannii ATCC 17978; accesion number YP_001084696)) or a fragment thereof, where the fragments are biologically active fragments, and preferably selected from the list consisting of SEQ ID NO: 12 to SEQ ID NO: 23, or any of its combinations, or sequences having at least 85% sequence identity with peptide sequences SEQ ID NO: 12 to SEC ID NO: 23.

[0199] 9. The composition according to any one of claims 6-8, further comprising the amino acid sequence SEQ ID NO: 28 and the amino acid sequence SEQ ID NO: 27.

[0200] 10. The composition according to any one of claims 6-9 further comprising a fusion protein comprising at least 2, preferably 3, more preferably 4 amino acid sequences form the list SEQ ID NO: 1 to SEQ ID NO: 23 or a variant of these sequences having at least 85% sequence identity with SEQ ID NO. 1 to SEQ ID NO: 23.

[0201] 11. The composition according to claim 10, wherein the fusion protein further comprises the amino acid sequence SEQ ID NO: 24 or the amino acid sequence SEQ ID NO: 25.

[0202] 12. The composition according to any one of claims 6-11, wherein the composition comprises a nucleotide sequence capable of transcribing an amino acid sequence as described in any one of claims 8-11.

[0203] 13. The composition according to claim 12, wherein the nucleotide sequence is the SEQ ID NO: 26.

[0204] 14. The composition according to any one of claims 6-13, further comprising an expression vector comprising the nucleotide sequence according to any one of claims 12-13

[0205] 15. The composition according to any one of claims 6-14, further comprising outer membrane vesicles deficient in LPS, or cells according to any one of claims 1 to 5.

[0206] 16. The composition according to any one of claims 6-14, further comprising at least one of the purified outer membrane proteins of A. baumannii with amino acid sequence SEQ ID NO: 29, SEQ ID NO: 30, SEQ ID NO: 31, SEQ ID NO: 32, SEQ ID NO: 33, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 36, SEQ ID NO: 37, SEQ ID NO: 38, SEQ ID NO: 39, SEQ ID NO: 40, SEQ ID NO: 41, SEQ ID NO: 42, SEQ ID NO: 43, SEQ ID NO: 44, SEQ ID NO: 45, SEQ ID NO: 46; SEQ ID NO: 47; SEQ ID NO: 48; SEQ ID NO: 49; SEQ ID NO: 50; SEQ ID NO: 51; SEQ ID NO: 52; SEQ ID NO: 53; SEQ ID NO: 54; SEQ ID NO: 55; SEQ ID NO: 56; SEQ ID NO: 57; SEQ ID NO: 58; SEQ ID NO: 59; SEQ ID NO: 60; SEQ ID NO: 61; SEQ ID NO: 62; SEQ ID NO: 63; SEQ ID NO: 64; SEQ ID NO: 65; SEQ ID NO: 66; SEQ ID NO: 67; SEQ ID NO: 68; SEQ ID NO: 69; SEQ ID NO: 70; SEQ ID NO: 71; SEQ ID NO: 72; SEQ ID NO: 73; SEQ ID NO: 74; SEQ ID NO: 75; SEQ ID NO: 76, SEQ ID NO: 77, SEQ ID NO: 78, SEQ ID NO: 79, SEQ ID NO: 80, SEQ ID NO: 81, SEQ ID NO: 82, SEQ ID NO: 83, SEQ ID NO: 84, SEQ ID NO: 85, SEQ ID NO: 86, SEQ ID NO: 87, SEQ ID NO: 88, SEQ ID NO: 89, or combinations thereof.

[0207] 17. An outer membrane vesicle that is deficient in LPS.

[0208] 18. The outer membrane vesicle according to claim 17, obtained from a cell according to any one of claims 1-5.

[0209] 19. The composition according to any one of claims 6-15, wherein the cells or the outer membrane vesicles are designed to produce the amino acid sequences according to any one of claim 8-11 or 16 and/or comprising the nucleotides or nucleic acids according to any one of claims 12-13.

[0210] 20. A nucleotide sequence capable of transcribing any fusion protein according to any one of claims 10-11.

[0211] 21. An expression vector comprising a nucleotide or a nucleic acid according to any one of claims 12-13.

[0212] 22. The composition according to any one of claims 7 to 16 and 19 that is a pharmaceutical composition.

[0213] 23. The composition according to claim 22, further comprising a pharmaceutically acceptable vehicle.

[0214] 24. The composition according to any one of claim 22 or 23, further comprising another active ingredient.

[0215] 25. The composition according to any one of claims 22-24, further comprising an adjuvant.

[0216] 26. The composition according to any one of claims 7 to 16, 19 to 22 and 25, wherein the composition is a vaccine.

[0217] 27. The composition according to any one of claims 7 to 16, 19 to 22, and 25 for use as a medicament.

[0218] 28. The composition according to any one of claims 7 to 16, 19 to 22, and 25 for the prevention, improvement or the treatment of an infection caused by A. baumannii in un mammal.

[0219] 29. The composition according to any one of claims 7 to 16, 19 to 22, and 25 for conferring protection against infection caused by A. baumannii in a mammal.

[0220] 30. An antibody or active fragment thereof obtained by immunization of a mammal with the composition according to any one of claims 7 to 16, 19 to 22 and 25.

[0221] 31. The antibody or fragment thereof of the previous claim, wherein the composition is a pharmaceutical composition and wherein said composition is used in therapy, particularly for the treatment and prevention of infection caused by A. baumannii.

[0222] Additional Clauses

[0223] 1.--An Acinetobacter cell deficient in LPS obtained by partial or complete inactivation of one or various cellular nucleic acid molecules that encode endogenous LPS biosynthesis genes.

[0224] 2.--The Acinetobacter cell according to the preceding claim, wherein the genes are selected from IpxA, IpxB and/or IpxC, or any of their combinations.

[0225] 3.--A composition comprising:

[0226] a) a cell according to any one of claims 1-2, and

[0227] b) a recombinant nucleic acid molecule, and/or a recombinant polypeptide.

[0228] 4.--The composition according to claim 3, wherein the polypeptide is selected from:

[0229] c) the peptide sequence SEQ ID NO: 27 (putative ferric siderophore receptor (A. baumannii ATCC 17978; accession number YP_001084684)) or a fragment thereof, wherein the fragments are biologically active fragments, and preferably selected from the list consisting of SEQ ID NO: 1 to SEQ ID NO: 11, or any of its combinations, or sequences having at least 85% sequence identity with peptide sequences SEQ ID NO: 1 to SEQ ID NO: 11, and/or

[0230] d) the peptide sequence SEQ ID NO: 28 (putative ferric hydroximate siderophore receptor (A. baumannii ATCC 17978; accesion number YP_001084696)) or a fragment thereof, where the fragments are biologically active fragments, and preferably selected from the list consisting of SEQ ID NO: 12 to SEQ ID NO: 23, or any of its combinations, or sequences having at least 85% sequence identity with peptide sequences SEQ ID NO: 12 to SEC ID NO: 23.

[0231] 5.--The composition according to any one of claims 3-4, wherein the composition comprises a nucleotide sequence capable of transcribing an amino acid sequence described in claim 4, preferably SEQ ID NO: 26.

[0232] 6.--The composition according to any one of claims 3-5, further comprising an outer membrane vesicle deficient in LPS, or cells according to any one of claims 1 and 2.

[0233] 7.--The composition according to any one of claims 3-6, further comprising at least one of the proteins purified from the outer membrane of A. baumannii SEQ ID NO: 29, SEQ ID NO: 30, SEQ ID NO: 31, SEQ ID NO: 32, SEQ ID NO: 33, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 36, SEQ ID NO: 37, SEQ ID NO: 38, SEQ ID NO: 39, SEQ ID NO: 40, SEQ ID NO: 41, SEQ ID NO: 42, SEQ ID NO: 43, SEQ ID NO: 44, SEQ ID NO: 45, SEQ ID NO: 46; SEQ ID NO: 47; SEQ ID NO: 48; SEQ ID NO: 49; SEQ ID NO: 50; SEQ ID NO: 51; SEQ ID NO: 52; SEQ ID NO: 53; SEQ ID NO: 54; SEQ ID NO: 55; SEQ ID NO: 56; SEQ ID NO: 57; SEQ ID NO: 58; SEQ ID NO: 59; SEQ ID NO: 60; SEQ ID NO: 61; SEQ ID NO: 62; SEQ ID NO: 63; SEQ ID NO: 64; SEQ ID NO: 65; SEQ ID NO: 66; SEQ ID NO: 67; SEQ ID NO: 68; SEQ ID NO: 69; SEQ ID NO: 70; SEQ ID NO: 71; SEQ ID NO: 72; SEQ ID NO: 73; SEQ ID NO: 74; SEQ ID NO: 75; SEQ ID NO: 76, SEQ ID NO: 77, SEQ ID NO: 78, SEQ ID NO: 79, SEQ ID NO: 80, SEQ ID NO: 81, SEQ ID NO: 82, SEQ ID NO: 83, SEQ ID NO: 84, SEQ ID NO: 85, SEQ ID NO: 86, SEQ ID NO: 87, SEQ ID NO: 88, SEQ ID NO: 89, or any combination thereof.

[0234] 8. An outer membrane vesicle deficient in LPS.

[0235] 9. The outer membrane vesicle according to claim 8, obtained from a cell as described in any one of claims 1-2.

[0236] 10. The composition according to any one of claims 3-7, wherein the cells or the outer membrane vesicles are designed to produce the polypeptide sequences according to any one of claims 4 and 7, and/or comprising the nucleic acid sequences of claim 5.

[0237] 11. The composition according to any one of claims 3-7 and 10, wherein the composition is a pharmaceutical composition.

[0238] 12. The composition according to any one of claims 3-7, 10 and 11 for use as a medicament.

[0239] 13. The composition according to any one of claims 3-7, 10 and 11 for use in the prevention, improvement or treatment of an infection caused by A. baumannii in a mammal.

[0240] 14. An antibody or active fragment thereof obtained by immunization of a mammal with the composition according to any one of claims 3 to 7, 10 and 11.

[0241] 15. The antibody or the active fragment thereof according to the preceding claim, wherein the composition is a pharmaceutical composition, and where said composition is used in therapy, particularly for the treatment or prevention of an infection caused by A. baumannii.

Sequence CWU 1 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 101 <210> SEQ ID NO 1 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(12) <223> OTHER INFORMATION: anti-A. baumannii immunogen <400> SEQUENCE: 1 Thr Ser Ser Asp Thr Phe Arg Ser Asp Gly Leu Ala 1 5 10 <210> SEQ ID NO 2 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(28) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 2 Thr Ser Arg Gly Ser Gln Phe Asp Gly Asn Gly Asp Arg Ile Ser Leu 1 5 10 15 Ser Pro Trp Gln Gly Ser Thr Met Asp Thr Asp Thr 20 25 <210> SEQ ID NO 3 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(41) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 3 Tyr Lys Lys Gln Asp Thr Asp Tyr Gly Pro Asp Tyr Ser Tyr Leu Pro 1 5 10 15 Thr Thr Ser Lys Ser Asn Asp Ala Thr Thr Pro Thr Tyr Lys Ala Ile 20 25 30 Lys Gly Leu Lys Leu Ser Asn Pro Leu 35 40 <210> SEQ ID NO 4 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(29) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 4 Arg Asn Glu Lys Ser Arg Phe Phe Pro Tyr Gly Leu Ser Asn Lys Ser 1 5 10 15 Val Thr Ser Val Asn Gln Ser Gln Ser Glu Ile Glu Val 20 25 <210> SEQ ID NO 5 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(36) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 5 Glu Lys Asp Lys Gln Phe Val Asp Ile Leu Ala Thr Gln Tyr Pro Tyr 1 5 10 15 Leu Val Tyr Thr Pro Thr Gly Gln Arg Lys Gly Tyr Gly Pro Asn Thr 20 25 30 Glu Ile Gln Asn 35 <210> SEQ ID NO 6 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(28) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 6 Ile Gln Ala Asp Thr Asp Ala Tyr Ile Pro Ser Arg Glu Thr Thr Met 1 5 10 15 Val Pro Ala Gly Ser Thr His Asp Asp Lys Pro Leu 20 25 <210> SEQ ID NO 7 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 7 Pro Asp Val Gln Arg Met Leu Arg Asp Val Ser Thr Tyr Thr Val Ser 1 5 10 15 Thr Ala Asn Leu Gln Pro Ile Thr Val Asn Ser 20 25 <210> SEQ ID NO 8 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(23) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 8 Asn Thr Ser Asp Lys Thr Val Gln Phe Asn Asn Arg Ala Ala Lys Val 1 5 10 15 Val Asp Thr Asp Gln Arg Val 20 <210> SEQ ID NO 9 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(22) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 9 Thr Arg Gly Gln Tyr Lys Asp Val Ala Asn Lys Trp His Glu Leu Asn 1 5 10 15 Ser Phe Thr Val Ala Pro 20 <210> SEQ ID NO 10 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(36) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 10 Ile Lys Gly Thr Asn Lys Ala Tyr Lys Asp Asp Arg Glu Leu Ala Ala 1 5 10 15 Phe Ala Thr Thr Gln Asp Glu Ala Phe Gln Asn Ala Val Lys Asn Asp 20 25 30 Ala Asn Ser Ala 35 <210> SEQ ID NO 11 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(33) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 11 Tyr Asn Val Trp Asn Arg Gln Tyr Arg Thr Val Phe Ala Gln Gln Ala 1 5 10 15 Ala Val Ser Asn Ala Asn Pro Leu Leu Ala Ile Pro Ala Glu Gly Arg 20 25 30 Thr <210> SEQ ID NO 12 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(28) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 12 Val Lys Gly Ala Asp Ser Leu Thr Asn Ala Phe Gly Asp Pro Ser Ala 1 5 10 15 Thr Ile Asn Asn Ile Arg Lys Arg Pro Thr Gln Glu 20 25 <210> SEQ ID NO 13 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(28) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 13 Ser Gly Lys Val Arg Gly Arg Ile Met Gly Tyr Glu Gln Thr Gly Asp 1 5 10 15 Ser Tyr Leu Asp Arg Tyr Ser Ala Glu Lys Asn Gly 20 25 <210> SEQ ID NO 14 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(11) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 14 Ser Gln Glu Gln Asn Lys Pro Asn Ala Asn Asn 1 5 10 <210> SEQ ID NO 15 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(15) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 15 Asn Pro Asn Pro Asp Trp Ala His Trp Asp Asn Glu Thr Gln Asn 1 5 10 15 <210> SEQ ID NO 16 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(36) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 16 Leu Asp Thr Lys His Asn Ser Arg Leu Leu Tyr Tyr Tyr Gly Tyr Pro 1 5 10 15 Lys Ala Asp Gly Ser Gly Val Ser Leu Thr Pro Trp Gly Gly Gln Glu 20 25 30 His Gln Glu Lys 35 <210> SEQ ID NO 17 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(50) <223> OTHER INFORMATION: Anti-A. Baumanii immunogen <400> SEQUENCE: 17 Val Arg Asn His Gln Gln Asp Lys Gln Ser Thr Gly Thr Ile Asn Asp 1 5 10 15 Ser Asn Val Ile Lys Ser Thr Thr Thr Asp Trp Ala Ser Trp Thr Pro 20 25 30 Gln Ser Ile Thr Trp Ser Asp Phe Thr Glu Ala Ala Asn Tyr Lys Gln 35 40 45 Asn Ile 50 <210> SEQ ID NO 18 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(20) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 18 Val Gln Ala Glu Ser Lys Gly Glu Ser Tyr Ser Ser Pro Met Ser Tyr 1 5 10 15 Ser Glu Ser Lys 20 <210> SEQ ID NO 19 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(21) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 19 Arg Pro Gln Thr Gly Ile Asp Lys Asp Thr Asn Gln Ala Leu Lys Pro 1 5 10 15 Ile Glu Gly Lys Ser 20 <210> SEQ ID NO 20 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(29) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 20 Thr Glu Gln Asn Asn Tyr Pro Leu Arg Asn Ser Asp Gly Asn Pro Leu 1 5 10 15 Asn Arg Lys Val Pro Thr Ser Asp Leu Glu Ser Gln Gly 20 25 <210> SEQ ID NO 21 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(20) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 21 Ala Gln Phe Ser Ile Lys Asp Thr Lys Asn Gly Gly Glu Ala Arg Thr 1 5 10 15 Tyr Asn Pro Asn 20 <210> SEQ ID NO 22 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(20) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 22 Gln Asp Gly Ile Lys Leu Tyr Asp Ser Asn Val Asn Gly Thr Ile Lys 1 5 10 15 Gln Asp Ala Tyr 20 <210> SEQ ID NO 23 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(20) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 23 Asp Lys Lys Tyr Leu Asn Ser Phe Pro Asp Gly Gln Ala Phe Tyr Gly 1 5 10 15 Ala Pro Ala Asn 20 <210> SEQ ID NO 24 <211> LENGTH: 586 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Fusion protein <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(586) <223> OTHER INFORMATION: Fusion protein <400> SEQUENCE: 24 Val Lys Gly Ala Asp Ser Leu Thr Asn Ala Phe Gly Asp Pro Ser Ala 1 5 10 15 Thr Ile Asn Asn Ile Arg Lys Arg Pro Thr Gln Glu Ser Gln Glu Gln 20 25 30 Asn Lys Pro Asn Ala Asn Asn Asn Pro Asn Pro Asp Trp Ala His Trp 35 40 45 Asp Asn Glu Thr Gln Asn Leu Asp Thr Lys His Asn Ser Arg Leu Leu 50 55 60 Tyr Tyr Tyr Gly Tyr Pro Lys Ala Asp Gly Ser Gly Val Ser Leu Thr 65 70 75 80 Pro Trp Gly Gly Gln Glu His Gln Glu Lys Val Arg Asn His Gln Gln 85 90 95 Asp Lys Gln Ser Thr Gly Thr Ile Asn Asp Ser Asn Val Ile Lys Ser 100 105 110 Thr Thr Thr Asp Trp Ala Ser Trp Thr Pro Gln Ser Ile Thr Trp Ser 115 120 125 Asp Phe Thr Glu Ala Ala Asn Tyr Lys Gln Asn Ile Val Gln Ala Glu 130 135 140 Ser Lys Gly Glu Ser Tyr Ser Ser Pro Met Ser Tyr Ser Glu Ser Lys 145 150 155 160 Arg Pro Gln Thr Gly Ile Asp Lys Asp Thr Asn Gln Ala Leu Lys Pro 165 170 175 Ile Glu Gly Lys Ser Thr Glu Gln Asn Asn Tyr Pro Leu Arg Asn Ser 180 185 190 Asp Gly Asn Pro Leu Asn Arg Lys Val Pro Thr Ser Asp Leu Glu Ser 195 200 205 Gln Gly Ala Gln Phe Ser Ile Lys Asp Thr Lys Asn Gly Gly Glu Ala 210 215 220 Arg Thr Tyr Asn Pro Asn Gln Asp Gly Ile Lys Leu Tyr Asp Ser Asn 225 230 235 240 Val Asn Gly Thr Ile Lys Gln Asp Ala Tyr Asp Lys Lys Tyr Leu Asn 245 250 255 Ser Phe Pro Asp Gly Gln Ala Phe Tyr Gly Ala Pro Ala Asn Thr Ser 260 265 270 Ser Asp Thr Phe Arg Ser Asp Gly Leu Ala Thr Ser Arg Gly Ser Gln 275 280 285 Phe Asp Gly Asn Gly Asp Arg Ile Ser Leu Ser Pro Trp Gln Gly Ser 290 295 300 Thr Met Asp Thr Asp Thr Tyr Lys Asp Lys Gln Asp Thr Asp Tyr Gly 305 310 315 320 Pro Asp Tyr Ser Tyr Leu Pro Thr Thr Ser Lys Ser Asn Asp Ala Thr 325 330 335 Thr Pro Thr Tyr Lys Ala Ile Lys Gly Leu Lys Leu Ser Asn Pro Leu 340 345 350 Arg Asn Glu Lys Ser Arg Phe Phe Pro Tyr Gly Leu Ser Asn Lys Ser 355 360 365 Val Thr Ser Val Asn Gln Ser Gln Ser Glu Ile Glu Val Glu Lys Asp 370 375 380 Lys Gln Phe Val Asp Ile Leu Ala Thr Gln Tyr Pro Tyr Leu Val Tyr 385 390 395 400 Thr Pro Thr Gly Gln Arg Lys Gly Tyr Gly Pro Asn Thr Glu Ile Gln 405 410 415 Asn Ile Gln Ala Asp Thr Asp Ala Tyr Ile Pro Ser Arg Glu Thr Thr 420 425 430 Met Val Pro Ala Gly Ser Thr His Asp Asp Lys Pro Leu Pro Asp Val 435 440 445 Gln Arg Met Leu Arg Asp Val Ser Thr Tyr Thr Val Ser Thr Ala Asn 450 455 460 Leu Gln Pro Ile Thr Val Asn Ser Asn Thr Ser Asp Lys Thr Val Gln 465 470 475 480 Phe Asn Asn Arg Ala Ala Lys Val Val Asp Thr Asp Gln Arg Val Thr 485 490 495 Arg Gly Gln Tyr Lys Asp Val Ala Asn Lys Trp His Glu Leu Asn Ser 500 505 510 Phe Thr Val Ala Pro Ile Lys Gly Thr Asn Lys Ala Tyr Lys Asp Asp 515 520 525 Arg Glu Leu Ala Ala Phe Ala Thr Thr Gln Asp Glu Ala Phe Gln Asn 530 535 540 Ala Val Lys Asn Asp Ala Asn Ser Ala Tyr Asn Val Trp Asn Arg Gln 545 550 555 560 Tyr Arg Thr Val Phe Ala Gln Gln Ala Ala Val Ser Asn Ala Asn Pro 565 570 575 Leu Leu Ala Ile Pro Ala Glu Gly Arg Thr 580 585 <210> SEQ ID NO 25 <211> LENGTH: 615 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Fusion protein <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(615) <223> OTHER INFORMATION: Fusion protein <400> SEQUENCE: 25 Met Ser Gly Lys Val Arg Gly Arg Ile Met Gly Tyr Glu Gln Thr Gly 1 5 10 15 Asp Ser Tyr Leu Asp Arg Tyr Ser Ala Glu Lys Asn Gly Val Lys Gly 20 25 30 Ala Asp Ser Leu Thr Asn Ala Phe Gly Asp Pro Ser Ala Thr Ile Asn 35 40 45 Asn Ile Arg Lys Arg Pro Thr Gln Glu Ser Gln Glu Gln Asn Lys Pro 50 55 60 Asn Ala Asn Asn Asn Pro Asn Pro Asp Trp Ala His Trp Asp Asn Glu 65 70 75 80 Thr Gln Asn Leu Asp Thr Lys His Asn Ser Arg Leu Leu Tyr Tyr Tyr 85 90 95 Gly Tyr Pro Lys Ala Asp Gly Ser Gly Val Ser Leu Thr Pro Trp Gly 100 105 110 Gly Gln Glu His Gln Glu Lys Val Arg Asn His Gln Gln Asp Lys Gln 115 120 125 Ser Thr Gly Thr Ile Asn Asp Ser Asn Val Ile Lys Ser Thr Thr Thr 130 135 140 Asp Trp Ala Ser Trp Thr Pro Gln Ser Ile Thr Trp Ser Asp Phe Thr 145 150 155 160 Glu Ala Ala Asn Tyr Lys Gln Asn Ile Val Gln Ala Glu Ser Lys Gly 165 170 175 Glu Ser Tyr Ser Ser Pro Met Ser Tyr Ser Glu Ser Lys Arg Pro Gln 180 185 190 Thr Gly Ile Asp Lys Asp Thr Asn Gln Ala Leu Lys Pro Ile Glu Gly 195 200 205 Lys Ser Thr Glu Gln Asn Asn Tyr Pro Leu Arg Asn Ser Asp Gly Asn 210 215 220 Pro Leu Asn Arg Lys Val Pro Thr Ser Asp Leu Glu Ser Gln Gly Ala 225 230 235 240 Gln Phe Ser Ile Lys Asp Thr Lys Asn Gly Gly Glu Ala Arg Thr Tyr 245 250 255 Asn Pro Asn Gln Asp Gly Ile Lys Leu Tyr Asp Ser Asn Val Asn Gly 260 265 270 Thr Ile Lys Gln Asp Ala Tyr Asp Lys Lys Tyr Leu Asn Ser Phe Pro 275 280 285 Asp Gly Gln Ala Phe Tyr Gly Ala Pro Ala Asn Thr Ser Ser Asp Thr 290 295 300 Phe Arg Ser Asp Gly Leu Ala Thr Ser Arg Gly Ser Gln Phe Asp Gly 305 310 315 320 Asn Gly Asp Arg Ile Ser Leu Ser Pro Trp Gln Gly Ser Thr Met Asp 325 330 335 Thr Asp Thr Tyr Lys Asp Lys Gln Asp Thr Asp Tyr Gly Pro Asp Tyr 340 345 350 Ser Tyr Leu Pro Thr Thr Ser Lys Ser Asn Asp Ala Thr Thr Pro Thr 355 360 365 Tyr Lys Ala Ile Lys Gly Leu Lys Leu Ser Asn Pro Leu Arg Asn Glu 370 375 380 Lys Ser Arg Phe Phe Pro Tyr Gly Leu Ser Asn Lys Ser Val Thr Ser 385 390 395 400 Val Asn Gln Ser Gln Ser Glu Ile Glu Val Glu Lys Asp Lys Gln Phe 405 410 415 Val Asp Ile Leu Ala Thr Gln Tyr Pro Tyr Leu Val Tyr Thr Pro Thr 420 425 430 Gly Gln Arg Lys Gly Tyr Gly Pro Asn Thr Glu Ile Gln Asn Ile Gln 435 440 445 Ala Asp Thr Asp Ala Tyr Ile Pro Ser Arg Glu Thr Thr Met Val Pro 450 455 460 Ala Gly Ser Thr His Asp Asp Lys Pro Leu Pro Asp Val Gln Arg Met 465 470 475 480 Leu Arg Asp Val Ser Thr Tyr Thr Val Ser Thr Ala Asn Leu Gln Pro 485 490 495 Ile Thr Val Asn Ser Asn Thr Ser Asp Lys Thr Val Gln Phe Asn Asn 500 505 510 Arg Ala Ala Lys Val Val Asp Thr Asp Gln Arg Val Thr Arg Gly Gln 515 520 525 Tyr Lys Asp Val Ala Asn Lys Trp His Glu Leu Asn Ser Phe Thr Val 530 535 540 Ala Pro Ile Lys Gly Thr Asn Lys Ala Tyr Lys Asp Asp Arg Glu Leu 545 550 555 560 Ala Ala Phe Ala Thr Thr Gln Asp Glu Ala Phe Gln Asn Ala Val Lys 565 570 575 Asn Asp Ala Asn Ser Ala Tyr Asn Val Trp Asn Arg Gln Tyr Arg Thr 580 585 590 Val Phe Ala Gln Gln Ala Ala Val Ser Asn Ala Asn Pro Leu Leu Ala 595 600 605 Ile Pro Ala Glu Gly Arg Thr 610 615 <210> SEQ ID NO 26 <211> LENGTH: 1650 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Polynucleotide coding for the fusion protein <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (1)..(1650) <223> OTHER INFORMATION: Polynucleotide coding for fusion protein <400> SEQUENCE: 26 atgtctggta aagttcgtgg tcgtatcatg ggttacgaac agaccggtga ctcttacctg 60 gaccgttact ctgctgaaaa aaacggtgtt aaaggtgctg actctctgac caacgctttc 120 ggtgacccgt ctgctaccat caacaacatc cgtaaacgtc cgacccagga atctcaggaa 180 cagaacaaac cgaacgctaa caacaacccg aacccggact gggctcactg ggacaacgaa 240 acccagaacc tggacaccaa acacaactct cgtctgctgt actactacgg ttacccgaaa 300 gctgacggtt ctggtgtttc tctgaccccg tggggtggtc aggaacacca ggaaaaagtt 360 cgtaaccacc agcaggacaa acagtctacc ggtaccatca acgactctaa cgttatcaaa 420 tctaccacca ccgactgggc ttcttggacc ccgcagtcta tcacctggtc tgacttcacc 480 gaagctgcta actacaaaca gaacatcgtt caggctgaat ctaaaggtga atcttactct 540 tctccgatgt cttactctga atctaaacgt ccgcagaccg gtatcgacaa agacaccaac 600 caggctctga aaccgatcga aggtaaatct accgaacaga acaactaccc gctgcgtaac 660 tctgacggta acccgctgaa ccgtaaagtt ccgacctctg acctggaatc tcagggtgct 720 cagttctcta tcaaagacac caaaaacggt ggtgaagctc gtacctacaa cccgaaccag 780 gacggtatca aactgtacga ctctaacgtt aacggtacca tcaaacagga cgcttacgac 840 aaaaaatacc tgaactcttt cccggacggt caggctttct acggtgctcc ggctaacacc 900 tcttctgaca ccttccgttc tgacggtctg gctacctctc gtggttctca gttcgacggt 960 aacggtgacc gtatctctct gtctccgtgg cagggttcta ccatggacac cgacacctac 1020 aaagacaaac aggacaccga ctacggtccg gactactctt acctgccgac cacctctaaa 1080 tctaacgacg ctaccacccc gacctacaaa gctatcaaag gtctgaaact gtctaacccg 1140 ctgcgtaacg aaaaatctcg tttcttcccg tacggtctgt ctaacaaatc tgttacctct 1200 gttaaccagt ctcagtctga aatcgaagtt gaaaaagaca aacagttcgt tgacatcctg 1260 gctacccagt acccgtacct ggtttacacc ccgaccggtc agcgtaaagg ttacggtccg 1320 aacaccgaaa tccagaacat ccaggctgac accgacgctt acatcccgtc tcgtgaaacc 1380 accatggttc cggctggttc tacccacgac gacaaaccgc tgccggacgt tcagcgtatg 1440 ctgcgtgacg tttctaccta caccgtttct accgctaacc tgcagccgat caccgttaac 1500 tctaacacct ctgacaaaac cgttcagttc aacaaccgtg ctgctaaagt tgttgacacc 1560 gaccagcgtg ttacccgtgg tcagtacaaa gacgttgcta acaaatggca cgaactgaac 1620 tctttcaccg ttgctccgat caaaggtacc 1650 <210> SEQ ID NO 27 <211> LENGTH: 746 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(746) <223> OTHER INFORMATION: Amino acid sequence of putative ferric siderophore receptor protein <400> SEQUENCE: 27 Met Thr Pro Cys Cys Leu Ala Ile Ser Ala Ile Phe Ala Gln Gln Ala 1 5 10 15 Tyr Ala Glu Thr Val Thr Gln Thr Ala Glu Val Ser Glu Asn Ala Thr 20 25 30 Gln Lys Pro Val Ala Gln Leu Gln Lys Ile Val Val Thr Ala Thr Arg 35 40 45 Thr Pro Lys Asn Ile Ala Glu Ile Ala Gly Thr Val Gln Ser Ile Asp 50 55 60 Gln Lys Gln Ile Ile Gln Gln Ala Thr Ala Gly Arg Lys Val Ala Asp 65 70 75 80 Ile Leu Ala Gln Leu Val Pro Ser Leu Ala Ser Ser Ser Gly Thr Thr 85 90 95 Ser Asn Tyr Gly Gln Thr Met Arg Gly Arg Asn Val Leu Val Met Ile 100 105 110 Asp Gly Val Ser Gln Thr Gly Ser Arg Asp Val Ser Arg Gln Leu Asn 115 120 125 Ser Ile Ser Pro Gly Met Ile Glu Arg Ile Glu Val Ile Ser Gly Ala 130 135 140 Thr Ser Ile Tyr Gly Ser Gly Ala Thr Gly Gly Ile Ile Asn Ile Ile 145 150 155 160 Thr Lys Arg Ala Asp Thr Ser Lys Pro Leu Ser Phe Glu Thr Lys Val 165 170 175 Gly Ile Thr Ser Ser Asp Thr Phe Arg Ser Asp Gly Leu Ala Tyr Glu 180 185 190 Val Gly Gln Ser Val Ser Phe Asn Lys Gly Asn Ile Asp Gly Phe Leu 195 200 205 Gly Ala Asn Phe Thr Ser Arg Gly Ser Gln Phe Asp Gly Asn Gly Asp 210 215 220 Arg Ile Ser Leu Ser Pro Trp Gln Gly Ser Thr Met Asp Thr Asp Thr 225 230 235 240 Ile Asp Val Asn Gly Arg Leu Asn Phe Asn Leu Asn Asp Thr Gln Thr 245 250 255 Leu Ser Phe Gly Ala Gln Tyr Tyr Lys Asp Lys Gln Asp Thr Asp Tyr 260 265 270 Gly Pro Asp Tyr Ser Tyr Leu Pro Thr Thr Ser Lys Ser Asn Asp Ala 275 280 285 Thr Thr Pro Thr Tyr Lys Ala Ile Lys Gly Leu Lys Leu Ser Asn Pro 290 295 300 Leu Phe Thr Glu Arg Tyr Ala Val Asn Ser Gln Tyr Gln Asn Gln Asp 305 310 315 320 Phe Leu Gly Gln Ile Leu Asn Val Glu Ala Tyr Tyr Arg Asn Glu Lys 325 330 335 Ser Arg Phe Phe Pro Tyr Gly Leu Ser Asn Lys Ser Val Thr Ser Val 340 345 350 Asn Gln Ser Gln Ser Glu Ile Glu Val Ala Gly Leu Arg Ser Thr Met 355 360 365 Gln Thr Asp Leu Asn Ile Ala Asn Arg Asp Met Lys Ile Thr Tyr Gly 370 375 380 Leu Asp Tyr Asp Trp Glu Lys Asp Lys Gln Phe Val Asp Ile Leu Ala 385 390 395 400 Thr Gln Tyr Pro Tyr Leu Val Tyr Thr Pro Thr Gly Gln Arg Lys Gly 405 410 415 Tyr Gly Pro Asn Thr Glu Ile Gln Asn Ile Gly Ala Phe Val Gln Ser 420 425 430 Asp Tyr Ala Val Thr Asp Lys Leu Asn Leu Gln Ala Gly Ile Arg Tyr 435 440 445 Gln Tyr Ile Gln Ala Asp Thr Asp Ala Tyr Ile Pro Ser Arg Glu Thr 450 455 460 Thr Met Val Pro Ala Gly Ser Thr His Asp Asp Lys Pro Leu Phe Asn 465 470 475 480 Leu Gly Ala Val Tyr Lys Leu Thr Asp Ala Gln Gln Val Tyr Ala Asn 485 490 495 Phe Ser Gln Gly Phe Ser Phe Pro Asp Val Gln Arg Met Leu Arg Asp 500 505 510 Val Ser Thr Tyr Thr Val Ser Thr Ala Asn Leu Gln Pro Ile Thr Val 515 520 525 Asn Ser Tyr Glu Leu Gly Trp Arg Leu Asn Gln Asp Asp Gly Leu Asn 530 535 540 Leu Gly Leu Thr Gly Phe Tyr Asn Thr Ser Asp Lys Thr Val Gln Phe 545 550 555 560 Asn Asn Arg Ala Ala Lys Val Val Asp Thr Asp Gln Arg Val Tyr Gly 565 570 575 Ala Glu Ala Thr Ile Ser Tyr Pro Phe Met Glu Asn Tyr Lys Val Gly 580 585 590 Gly Thr Leu Gly Tyr Thr Arg Gly Gln Tyr Lys Asp Val Ala Asn Lys 595 600 605 Trp His Glu Leu Asn Ser Phe Thr Val Ala Pro Val Lys Gly Thr Leu 610 615 620 Phe Ala Glu Trp Asp Asn Asn Glu Gly Tyr Gly Val Arg Val Gln Met 625 630 635 640 Gln Ala Ile Lys Gly Thr Asn Lys Ala Tyr Lys Asp Asp Arg Glu Leu 645 650 655 Ala Ala Phe Ala Thr Thr Gln Asp Glu Ala Phe Gln Asn Ala Val Lys 660 665 670 Asn Asp Ala Asn Ser Ala Ala Gln Ile Lys Gly Tyr Thr Thr Met Asp 675 680 685 Val Leu Ala His Phe Pro Ala Trp Lys Gly Arg Val Asp Phe Gly Val 690 695 700 Tyr Asn Val Trp Asn Arg Gln Tyr Arg Thr Val Phe Ala Gln Gln Ala 705 710 715 720 Ala Val Ser Asn Ala Asn Pro Leu Leu Ala Ile Pro Ala Glu Gly Arg 725 730 735 Thr Tyr Gly Leu Ser Tyr Thr Phe Asn Tyr 740 745 <210> SEQ ID NO 28 <211> LENGTH: 679 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(679) <223> OTHER INFORMATION: Amino acid sequence of putative ferric hydroxamate siderophore receptor <400> SEQUENCE: 28 Met Gln Thr Ile Gln Val Lys Ala Ser Asp Ala Glu Gln Ser Ser Glu 1 5 10 15 Gln Thr Lys Ala Tyr Asn Val Lys Asn Ser Ser Ser Ala Thr Lys Leu 20 25 30 Asn Ile Glu Ala Lys Glu Thr Pro Gln Thr Ile Asn Val Val Thr Arg 35 40 45 Gln Gln Ile Glu Asp Phe Gly Leu Thr Ser Thr Arg Asp Val Leu Arg 50 55 60 Asn Thr Pro Gly Val Thr Val Ser Asn Gln Glu Thr Glu Arg Thr Thr 65 70 75 80 Tyr Met Ala Arg Gly Phe Glu Ile Ser Asn Ile Leu Thr Asp Gly Val 85 90 95 Gly Phe Pro Leu Ser Gly Tyr Asn Tyr Asn Asn Thr Asn Pro Asp Thr 100 105 110 Tyr Phe Tyr Asp Arg Val Glu Val Val Lys Gly Ala Asp Ser Leu Thr 115 120 125 Asn Ala Phe Gly Asp Pro Ser Ala Thr Ile Asn Asn Ile Arg Lys Arg 130 135 140 Pro Thr Gln Glu Phe Gln Ala Ser Asp Gly Val Ser Tyr Gly Ser Trp 145 150 155 160 Asp Thr Gln Arg Tyr Glu Ala Asp Val Ser Gly Ser Ile Leu Pro Ser 165 170 175 Gly Lys Val Arg Gly Arg Ile Met Gly Tyr Glu Gln Thr Gly Asp Ser 180 185 190 Tyr Leu Asp Arg Tyr Ser Ala Glu Lys Asn Gly Phe Ala Gly Ile Val 195 200 205 Glu Ala Asp Leu Thr Asp Ser Thr Leu Leu Thr Ala Gly Tyr Ser Gln 210 215 220 Glu Gln Asn Lys Pro Asn Ala Asn Asn Trp Gly Ala Leu Pro Leu Leu 225 230 235 240 Asp Ala Asn Gly Lys Gln Ile Ser Tyr Asp Arg Ser Tyr Asn Pro Asn 245 250 255 Pro Asp Trp Ala His Trp Asp Asn Glu Thr Gln Asn Ala Phe Val Glu 260 265 270 Leu Lys Gln Lys Leu Asn Asp Gln Trp Asn Ala Lys Leu Thr Tyr Asn 275 280 285 Tyr Leu Asp Thr Lys His Asn Ser Arg Leu Leu Tyr Tyr Tyr Gly Tyr 290 295 300 Pro Lys Ala Asp Gly Ser Gly Val Ser Leu Thr Pro Trp Gly Gly Gln 305 310 315 320 Glu His Gln Glu Lys His Ala Val Asp Phe Asn Leu Glu Gly Thr Tyr 325 330 335 Lys Leu Phe Asn Arg Glu His Glu Ala Thr Leu Gly Tyr Ser Tyr Val 340 345 350 Arg Asn His Gln Gln Asp Lys Gln Ser Thr Gly Thr Ile Asn Asp Ser 355 360 365 Asn Val Ile Lys Ser Thr Thr Thr Asp Trp Ala Ser Trp Thr Pro Gln 370 375 380 Ser Ile Thr Trp Ser Ala Phe Thr Glu Ala Ala Asn Tyr Lys Gln Asn 385 390 395 400 Ile Asn Ser Ile Tyr Ala Ala Thr Arg Leu His Leu Asn Glu Asp Leu 405 410 415 Lys Leu Leu Leu Gly Val Asn Tyr Val Gln Ala Glu Ser Lys Gly Glu 420 425 430 Ser Tyr Ser Ser Pro Met Ser Tyr Ser Glu Ser Lys Val Ser Pro Tyr 435 440 445 Val Gly Leu Thr Tyr Asn Phe Thr Pro Glu Tyr Thr Gly Tyr Met Ser 450 455 460 Tyr Thr Ser Ile Phe Arg Pro Gln Thr Gly Ile Asp Lys Asp Thr Asn 465 470 475 480 Gln Ala Leu Lys Pro Ile Glu Gly Lys Ser Tyr Glu Met Gly Val Lys 485 490 495 Ser Ser Trp Leu Asp Asp Arg Leu Thr Gly Thr Leu Ser Val Phe Lys 500 505 510 Thr Glu Gln Asn Asn Tyr Pro Leu Arg Asn Ser Asp Gly Asn Pro Leu 515 520 525 Asn Arg Lys Val Pro Thr Ser Asp Leu Glu Ser Gln Gly Val Glu Val 530 535 540 Gly Leu Ser Gly Gln Ile Thr Asp Asn Val Asn Leu Ser Leu Gly Tyr 545 550 555 560 Ala Gln Phe Ser Ile Lys Asp Thr Lys Asn Gly Gly Glu Ala Arg Ile 565 570 575 Tyr Asn Pro Asn Gln Thr Leu Asn Leu Leu Thr Thr Tyr Thr Pro Pro 580 585 590 Val Leu Pro Lys Leu Lys Val Gly Ala Gly Leu Gln Trp Gln Asp Gly 595 600 605 Ile Lys Leu Tyr Asp Ser Asn Val Asn Gly Thr Ile Lys Gln Asp Ala 610 615 620 Tyr Ala Leu Val Asn Leu Met Ala Ser Tyr Glu Val Asn Asp His Ile 625 630 635 640 Thr Leu Gln Ala Asn Gly Asn Asn Ile Phe Asp Lys Lys Tyr Leu Asn 645 650 655 Ser Phe Pro Asp Gly Gln Ala Phe Tyr Gly Ala Pro Ala Asn Tyr Thr 660 665 670 Val Ala Val Lys Phe Lys Tyr 675 <210> SEQ ID NO 29 <211> LENGTH: 829 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 29 Met Pro Leu Ala Leu Val Ser Ala Met Ala Ala Val Gln Gln Ala Tyr 1 5 10 15 Ala Ala Asp Asp Phe Val Val Arg Asp Ile Arg Val Asn Gly Leu Val 20 25 30 Arg Leu Thr Pro Ala Asn Val Tyr Thr Met Leu Pro Ile Asn Ser Gly 35 40 45 Asp Arg Val Asn Glu Pro Met Ile Ala Glu Ala Ile Arg Thr Leu Tyr 50 55 60 Ala Thr Gly Leu Phe Asp Asp Ile Lys Ala Ser Lys Glu Asn Asp Thr 65 70 75 80 Leu Val Phe Asn Val Ile Glu Arg Pro Ile Ile Ser Lys Leu Glu Phe 85 90 95 Lys Gly Asn Lys Leu Ile Pro Lys Glu Ala Leu Glu Gln Gly Leu Lys 100 105 110 Lys Met Gly Ile Ala Glu Gly Glu Val Phe Lys Lys Ser Ala Leu Gln 115 120 125 Thr Ile Glu Thr Glu Leu Glu Gln Gln Tyr Thr Gln Gln Gly Arg Tyr 130 135 140 Asp Ala Asp Val Thr Val Asp Thr Val Ala Arg Pro Asn Asn Arg Val 145 150 155 160 Glu Leu Lys Ile Asn Phe Asn Glu Gly Thr Pro Ala Lys Val Phe Asp 165 170 175 Ile Asn Val Ile Gly Asn Thr Val Phe Lys Asp Ser Glu Ile Lys Gln 180 185 190 Ala Phe Ala Val Lys Glu Ser Gly Trp Ala Ser Val Val Thr Arg Asn 195 200 205 Asp Arg Tyr Ala Arg Glu Lys Met Ala Ala Ser Leu Glu Ala Leu Arg 210 215 220 Ala Met Tyr Leu Asn Lys Gly Tyr Ile Asn Phe Asn Ile Asn Asn Ser 225 230 235 240 Gln Leu Asn Ile Ser Glu Asp Lys Lys His Ile Phe Ile Glu Val Ala 245 250 255 Val Asp Glu Gly Ser Gln Phe Lys Phe Gly Gln Thr Lys Phe Leu Gly 260 265 270 Asp Ala Leu Tyr Lys Pro Glu Glu Leu Gln Ala Leu Lys Ile Tyr Lys 275 280 285 Asp Gly Asp Thr Tyr Ser Gln Glu Lys Val Asn Ala Val Lys Gln Leu 290 295 300 Leu Leu Arg Lys Tyr Gly Asn Ala Gly Tyr Tyr Phe Ala Asp Val Asn 305 310 315 320 Ile Val Pro Gln Ile Asn Asn Glu Thr Gly Val Val Asp Leu Asn Tyr 325 330 335 Tyr Val Asn Pro Gly Gln Gln Val Thr Val Arg Arg Ile Asn Phe Thr 340 345 350 Gly Asn Ser Lys Thr Ser Asp Glu Val Leu Arg Arg Glu Met Arg Gln 355 360 365 Met Glu Gly Ala Leu Ala Ser Asn Glu Lys Ile Asp Leu Ser Lys Val 370 375 380 Arg Leu Glu Arg Thr Gly Phe Phe Lys Thr Val Asp Ile Lys Pro Ala 385 390 395 400 Arg Ile Pro Asn Ser Pro Asp Gln Val Asp Leu Asn Val Asn Val Glu 405 410 415 Glu Gln His Ser Gly Thr Thr Thr Leu Ala Val Gly Tyr Ser Gln Ser 420 425 430 Gly Gly Ile Thr Phe Gln Ala Gly Leu Ser Gln Thr Asn Phe Met Gly 435 440 445 Thr Gly Asn Arg Val Ala Ile Asp Leu Ser Arg Ser Glu Thr Gln Asp 450 455 460 Tyr Tyr Asn Leu Ser Val Thr Asp Pro Tyr Phe Thr Ile Asp Gly Val 465 470 475 480 Ser Arg Gly Tyr Asn Val Tyr Tyr Arg Lys Thr Lys Leu Asn Asp Asp 485 490 495 Tyr Asn Val Asn Asn Tyr Val Thr Asp Ser Phe Gly Gly Ser Leu Ser 500 505 510 Phe Gly Tyr Pro Ile Asp Glu Asn Gln Ser Leu Ser Ala Ser Val Gly 515 520 525 Val Asp Asn Thr Lys Val Thr Thr Gly Ala Phe Val Ser Thr Tyr Val 530 535 540 Arg Asp Tyr Leu Leu Ala Asn Gly Gly Lys Thr Thr Ser Thr Asn Thr 545 550 555 560 Tyr Cys Leu Val Asp Leu Val Gln Asp Pro Gln Thr Gly Leu Tyr Lys 565 570 575 Cys Pro Glu Gly Gln Thr Ser Gln Pro Tyr Gly Asn Ala Phe Glu Gly 580 585 590 Glu Phe Phe Thr Tyr Asn Leu Asn Leu Gly Trp Ser Tyr Asn Thr Leu 595 600 605 Asn Arg Pro Ile Phe Pro Thr Ser Gly Met Ser His Arg Val Gly Leu 610 615 620 Glu Ile Gly Leu Pro Gly Ser Asp Val Asp Tyr Gln Lys Val Thr Tyr 625 630 635 640 Asp Thr Gln Ala Phe Phe Pro Ile Gly Ser Thr Gly Phe Val Leu Arg 645 650 655 Gly Tyr Gly Lys Leu Gly Tyr Gly Asn Asp Leu Pro Phe Tyr Lys Asn 660 665 670 Phe Tyr Ala Gly Gly Tyr Gly Ser Val Arg Gly Tyr Asp Asn Ser Thr 675 680 685 Leu Gly Pro Lys Tyr Ala Ser Val Asn Leu Gln Glu Glu Lys Lys Asn 690 695 700 Asp Ser Ser Pro Glu Glu Val Gly Gly Asn Ala Leu Val Gln Phe Gly 705 710 715 720 Thr Glu Leu Val Leu Pro Met Pro Phe Lys Gly Asp Trp Thr Arg Gln 725 730 735 Val Arg Pro Val Leu Phe Ala Glu Gly Gly Gln Val Phe Asp Thr Lys 740 745 750 Cys Asp Val Arg Ser Tyr Ser Met Ile Met Asn Gly Gln Gln Ile Ser 755 760 765 Asp Ala Lys Lys Tyr Cys Glu Asp Asn Tyr Gly Phe Asp Leu Gly Asn 770 775 780 Leu Arg Tyr Ser Val Gly Val Gly Val Thr Trp Ile Thr Met Ile Gly 785 790 795 800 Pro Leu Ser Leu Ser Tyr Ala Phe Pro Leu Asn Asp Lys Pro Gly Asp 805 810 815 Glu Thr Lys Glu Ile Gln Phe Glu Ile Gly Arg Thr Phe 820 825 <210> SEQ ID NO 30 <211> LENGTH: 458 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 30 Met Arg Gly Pro Glu Pro Val Val Lys Thr Asp Ile Pro Gln Ser Tyr 1 5 10 15 Ala Tyr Asn Ser Ala Ser Gly Thr Ser Ile Ala Glu Gln Gly Tyr Lys 20 25 30 Gln Phe Phe Ala Asp Pro Arg Leu Leu Glu Val Ile Asp Leu Ala Leu 35 40 45 Ala Asn Asn Arg Asp Leu Arg Thr Ala Thr Leu Asn Ile Glu Arg Ala 50 55 60 Gln Gln Gln Tyr Gln Ile Thr Gln Asn Asn Gln Leu Pro Thr Ile Gly 65 70 75 80 Ala Ser Gly Ser Ala Ile Arg Gln Val Ser Gln Ser Arg Asp Pro Asn 85 90 95 Asn Pro Tyr Ser Thr Tyr Gln Val Gly Leu Gly Val Thr Ala Tyr Glu 100 105 110 Leu Asp Phe Trp Gly Arg Val Arg Ser Leu Lys Asp Ala Ala Leu Asp 115 120 125 Ser Tyr Leu Ala Thr Gln Ser Ala Arg Asp Ser Thr Gln Ile Ser Leu 130 135 140 Ile Ser Gln Val Ala Gln Ala Trp Leu Asn Tyr Ser Phe Ala Thr Ala 145 150 155 160 Asn Leu Arg Leu Ala Glu Gln Thr Leu Lys Ala Gln Leu Asp Ser Tyr 165 170 175 Asn Leu Asn Lys Lys Arg Phe Asp Val Gly Ile Asp Ser Glu Val Pro 180 185 190 Leu Arg Gln Ala Gln Ile Ser Val Glu Thr Ala Arg Asn Asp Val Ala 195 200 205 Asn Tyr Lys Thr Gln Ile Ala Gln Ala Gln Asn Leu Leu Asn Leu Leu 210 215 220 Val Gly Gln Pro Val Pro Gln Asn Leu Leu Pro Thr Gln Pro Val Lys 225 230 235 240 Arg Ile Ala Gln Gln Asn Val Phe Thr Ala Gly Leu Pro Ser Asp Leu 245 250 255 Leu Asn Asn Arg Pro Asp Val Lys Ala Ala Glu Tyr Asn Leu Ser Ala 260 265 270 Ala Gly Ala Asn Ile Gly Ala Ala Lys Ala Arg Leu Phe Pro Thr Ile 275 280 285 Ser Leu Thr Gly Ser Ala Gly Tyr Ala Ser Thr Asp Leu Ser Asp Leu 290 295 300 Phe Lys Ser Gly Gly Phe Val Trp Ser Val Gly Pro Ser Leu Asp Leu 305 310 315 320 Pro Ile Phe Asp Trp Gly Thr Arg Arg Ala Asn Val Lys Ile Ser Glu 325 330 335 Thr Asp Gln Lys Ile Ala Leu Ser Asp Tyr Glu Lys Ser Val Gln Ser 340 345 350 Ala Phe Arg Glu Val Asn Asp Ala Leu Ala Thr Arg Ala Asn Ile Gly 355 360 365 Glu Arg Leu Thr Ala Gln Gln Arg Leu Val Glu Ala Thr Asn Arg Asn 370 375 380 Tyr Thr Leu Ser Asn Ala Arg Phe Arg Ala Gly Ile Asp Ser Tyr Leu 385 390 395 400 Thr Val Leu Asp Ala Gln Arg Ser Ser Tyr Ala Ala Glu Gln Gly Leu 405 410 415 Leu Leu Leu Gln Gln Ala Asn Leu Asn Asn Gln Ile Glu Leu Tyr Lys 420 425 430 Thr Leu Gly Gly Gly Leu Lys Ala Asn Thr Ser Asp Thr Val Val His 435 440 445 Gln Pro Ser Ser Ala Glu Leu Lys Lys Gln 450 455 <210> SEQ ID NO 31 <211> LENGTH: 412 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 31 Met Met Ser Gly Ala Asn Ala Ala Thr Ser Asp Lys Glu Glu Ile Arg 1 5 10 15 Lys Leu Arg Gln Glu Val Glu Ala Leu Lys Ala Leu Val Gln Glu Gln 20 25 30 Arg Gln Val Gln Gln Gln Gln Gln Gln Val Gln Gln Gln Gln Gln Val 35 40 45 Gln Leu Ala Glu Val Lys Ala Gln Pro Gln Pro Val Ala Ala Pro Val 50 55 60 Ser Pro Leu Ala Gly Phe Lys Ser Lys Ala Gly Ala Asp Val Asn Leu 65 70 75 80 Tyr Gly Phe Val Arg Gly Asp Ala Asn Tyr Ile Ile Glu Gly Ala Asp 85 90 95 Asn Asp Phe Gly Asp Val Ser Lys Ser Asp Gly Lys Thr His Asp Lys 100 105 110 Leu Arg Ala Thr Ala Lys Thr Thr Arg Leu Gly Leu Asp Phe Asn Thr 115 120 125 Pro Val Gly Asp Asp Lys Val Gly Gly Lys Ile Glu Val Asp Phe Ala 130 135 140 Gly Ser Thr Thr Asp Ser Asn Gly Ser Leu Arg Ile Arg His Ala Tyr 145 150 155 160 Leu Thr Tyr Asn Asn Trp Leu Phe Gly Gln Thr Thr Ser Asn Phe Leu 165 170 175 Ser Asn His Ala Pro Glu Met Ile Asp Phe Ser Thr Asn Ile Gly Gly 180 185 190 Gly Thr Lys Arg Val Pro Gln Val Arg Tyr Asn Tyr Lys Leu Gly Pro 195 200 205 Thr Thr Gln Leu Phe Val Ser Ala Glu Lys Gly Asp Ser Thr Thr Ser 210 215 220 Val Thr Gly Asp Ser Ile Lys Tyr Ser Leu Pro Ala Leu Thr Ala Lys 225 230 235 240 Ile Thr Gln Gly Tyr Ala Glu Gly Arg Gly Ser Ala Ser Ala Arg Val 245 250 255 Leu Val Glu Asn Tyr Lys Ser Gln Leu Ala Asp Asp Asp Lys Thr Gly 260 265 270 Trp Gly Val Ala Val Gly Thr Asp Phe Lys Val Ser Asp Pro Leu Lys 275 280 285 Leu Phe Ala Asp Ala Ser Tyr Val Val Gly Asp Asn Ser Tyr Leu Tyr 290 295 300 Gly Ser Asn Ser Pro Tyr Ala Val Asp Gly Asn Ser Ile Glu Gln Asn 305 310 315 320 Glu Phe Val Ala Val Gln Val Gly Gly Thr Tyr Lys Ile Leu Pro Asn 325 330 335 Leu Arg Ser Thr Leu Ala Tyr Gly Ala Gln Phe Ser Asp Asp Gly Thr 340 345 350 Asp Tyr Ala Arg Leu Asn Ala Ser Ala Asn Glu Lys Val Gln Gln Ala 355 360 365 Trp Ile Asn Phe Ile Tyr Thr Pro Val Lys Pro Ile Asp Leu Gly Val 370 375 380 Glu Tyr Val Asn Gly Lys Arg Asp Thr Phe Asp Gly Lys Ser Tyr Lys 385 390 395 400 Asp Asn Arg Val Gly Leu Met Ala Lys Tyr Ser Phe 405 410 <210> SEQ ID NO 32 <211> LENGTH: 233 <212> TYPE: PRT <213> ORGANISM: putative outer membrane protein <400> SEQUENCE: 32 Tyr Gln Ala Glu Val Gly Gly Ser Tyr Asn Tyr Leu Asp Pro Asp Asn 1 5 10 15 Gly Ser Ser Val Ser Lys Phe Gly Val Asp Gly Thr Tyr Tyr Phe Asn 20 25 30 Pro Val Gln Thr Arg Asn Ala Pro Leu Ala Glu Ala Ala Phe Leu Asn 35 40 45 Arg Ala Ser Asn Val Asn Ala His Val Asn Tyr Gly Asp Asn Ser Gly 50 55 60 Thr Lys Asp Thr Gln Tyr Gly Val Gly Val Glu Tyr Phe Val Pro Asn 65 70 75 80 Ser Asp Phe Tyr Leu Ser Gly Asp Val Gly Arg Asn Glu Arg Glu Ile 85 90 95 Asp Asn Thr Asn Ile Asp Ser Lys Val Thr Thr Tyr Ala Ala Glu Val 100 105 110 Gly Tyr Leu Pro Ala Pro Gly Leu Leu Leu Ala Leu Gly Val Lys Gly 115 120 125 Tyr Asp Glu Lys Asp Gly Lys Asp Gly Ala Asp Pro Thr Val Arg Ala 130 135 140 Lys Tyr Val Thr Gln Val Gly Gln His Asp Val Asn Leu Glu Ala Tyr 145 150 155 160 Gly Ala Phe Gly Asp Leu Asp Glu Tyr Lys Val Arg Gly Asp Tyr Tyr 165 170 175 Ile Asp Lys Thr Leu Ser Leu Gly Val Asp Tyr Tyr Asn Asn Asp Leu 180 185 190 Thr Asp Lys Asp Glu Phe Gly Ile Asn Ala Lys Lys Phe Leu Asn Gln 195 200 205 Gln Val Ser Val Glu Gly Arg Val Gly Phe Gly Asp Asn Asp Asn Thr 210 215 220 Tyr Gly Val Arg Ala Ala Tyr Arg Phe 225 230 <210> SEQ ID NO 33 <211> LENGTH: 364 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 33 Met Gly Cys Ser Ser Asn Pro Ser Lys Lys Glu Val Val Asp Thr Gly 1 5 10 15 Pro Gln Ser Ser Glu Gln Ala Tyr Phe Asp Lys Ala Gln Lys Ala Leu 20 25 30 Asp Arg Gly Gln Tyr Leu Asp Ala Thr Lys Ser Leu Glu Ala Ile Asp 35 40 45 Thr Tyr Tyr Pro Thr Gly Gln Tyr Ala Gln Gln Ala Gln Leu Glu Leu 50 55 60 Leu Tyr Ser Lys Phe Lys Gln Lys Asp Tyr Glu Gly Ala Ile Ala Leu 65 70 75 80 Ala Glu Arg Phe Ile Arg Leu Asn Pro Gln His Pro Asn Val Asp Tyr 85 90 95 Ala Tyr Tyr Val Arg Gly Val Ser Asn Met Glu Met Asn Tyr Asp Ser 100 105 110 Leu Leu Arg Tyr Thr Ser Leu Gln Gln Ser His Arg Asp Val Ser Tyr 115 120 125 Leu Lys Val Ala Tyr Gln Asn Phe Val Asp Leu Ile Arg Arg Phe Pro 130 135 140 Ser Ser Gln Tyr Ser Val Asp Ala Ala Gln Arg Met Lys Phe Ile Gly 145 150 155 160 Gln Glu Leu Ala Glu Ser Glu Met Asn Ala Ala Arg Phe Asn Val Lys 165 170 175 Arg Lys Ala Trp Ile Ala Ala Ala Glu Arg Ser Gln Trp Val Ile Glu 180 185 190 His Tyr Pro Gln Thr Pro Gln Val Pro Glu Ala Leu Ala Thr Leu Ala 195 200 205 Tyr Ser Tyr Asp Gln Leu Gly Asp Lys Ala Thr Ser Gln Gln Tyr Ile 210 215 220 Glu Val Leu Lys Leu Asn Tyr Pro Ser Leu Val Asn Lys Asn Gly Thr 225 230 235 240 Val Asn Met Arg Ala Ala Arg Lys Glu Gly Asn Trp Ile Asn Arg Ala 245 250 255 Thr Leu Gly Ile Leu Gly Arg Glu Ser Lys Ser Val Thr Pro Asp Thr 260 265 270 Thr Thr Ser Ser Glu Ala Glu Pro Lys Arg Ser Leu Leu Asn Arg Val 275 280 285 Ser Phe Gly Leu Ile Gly Asn Ser Gly Lys Glu Glu Thr Glu Glu Thr 290 295 300 Thr Asn Thr Pro Val Glu Ala Pro Lys Ser Glu Arg Ser Trp Thr Asn 305 310 315 320 Arg Leu Ser Phe Gly Leu Leu Asp Lys Pro Lys Pro Lys Ala Ala Glu 325 330 335 Gly Ala Thr Ile Ala Pro Ala Thr Ser Ser Ser Glu Ala Pro Ser Ala 340 345 350 Ser Pro Ala Asp Asn Glu Ala Asp Asp Ala Ala Gln 355 360 <210> SEQ ID NO 34 <211> LENGTH: 356 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 34 Met Lys Leu Ser Arg Ile Ala Leu Ala Thr Met Leu Val Ala Ala Pro 1 5 10 15 Leu Ala Ala Ala Asn Ala Gly Val Thr Val Thr Pro Leu Leu Leu Gly 20 25 30 Tyr Thr Phe Gln Asp Ser Gln His Asn Asn Gly Gly Lys Asp Gly Asn 35 40 45 Leu Thr Asn Gly Pro Glu Leu Gln Asp Asp Leu Phe Val Gly Ala Ala 50 55 60 Leu Gly Ile Glu Leu Thr Pro Trp Leu Gly Phe Glu Ala Glu Tyr Asn 65 70 75 80 Gln Val Lys Gly Asp Val Asp Gly Ala Ser Ala Gly Ala Glu Tyr Lys 85 90 95 Gln Lys Gln Ile Asn Gly Asn Phe Tyr Val Thr Ser Asp Leu Ile Thr 100 105 110 Lys Asn Tyr Asp Ser Lys Ile Lys Pro Tyr Val Leu Leu Gly Ala Gly 115 120 125 His Tyr Lys Tyr Asp Phe Asp Gly Val Asn Arg Gly Thr Arg Gly Thr 130 135 140 Ser Glu Glu Gly Thr Leu Gly Asn Ala Gly Val Gly Ala Phe Trp Arg 145 150 155 160 Leu Asn Asp Ala Leu Ser Leu Arg Thr Glu Ala Arg Ala Thr Tyr Asn 165 170 175 Ala Asp Glu Glu Phe Trp Asn Tyr Thr Ala Leu Ala Gly Leu Asn Val 180 185 190 Val Leu Gly Gly His Leu Lys Pro Ala Ala Pro Val Val Glu Val Ala 195 200 205 Pro Val Glu Pro Thr Pro Val Ala Pro Gln Pro Gln Glu Leu Thr Glu 210 215 220 Asp Leu Asn Met Glu Leu Arg Val Phe Phe Asp Thr Asn Lys Ser Asn 225 230 235 240 Ile Lys Asp Gln Tyr Lys Pro Glu Ile Ala Lys Val Ala Glu Lys Leu 245 250 255 Ser Glu Tyr Pro Asn Ala Thr Ala Arg Ile Glu Gly His Thr Asp Asn 260 265 270 Thr Gly Pro Arg Lys Leu Asn Glu Arg Leu Ser Leu Ala Arg Ala Asn 275 280 285 Ser Val Lys Ser Ala Leu Val Asn Glu Tyr Asn Val Asp Ala Ser Arg 290 295 300 Leu Ser Thr Gln Gly Phe Ala Trp Asp Gln Pro Ile Ala Asp Asn Lys 305 310 315 320 Thr Lys Glu Gly Arg Ala Met Asn Arg Arg Val Phe Ala Thr Ile Thr 325 330 335 Gly Ser Arg Thr Val Val Val Gln Pro Gly Gln Glu Ala Ala Ala Pro 340 345 350 Ala Ala Ala Gln 355 <210> SEQ ID NO 35 <211> LENGTH: 581 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 35 Met Asn Gln Glu Thr Gly Arg Gly Val Thr Arg Gly Thr Lys Leu Tyr 1 5 10 15 Val Lys Asp Val Pro Val Leu Ala Val Pro Tyr Phe Asn Phe Pro Ile 20 25 30 Asp Asp Arg Arg Thr Thr Gly Ile Leu Asn Pro Gln Phe Gly Phe Ser 35 40 45 Asn Asp Gly Gly Ile Glu Leu Ser Val Pro Val Tyr Leu Asn Leu Ala 50 55 60 Pro Asn Tyr Asp Ala Thr Ile Thr Pro Arg Tyr Leu Ala Asp Arg Gly 65 70 75 80 Ala Met Leu Gln Gly Glu Phe Arg Tyr Leu Thr Asp Gly Phe Gly Ala 85 90 95 Gly Gln Ile Trp Gly Gly Ile Leu Pro Ser Asp Lys Glu Tyr Asp Asp 100 105 110 Lys Asp Arg Lys Asp Phe His Phe Leu His Asn Trp Asp Ile Asn Asp 115 120 125 Gln Trp Ser Thr Asn Leu Glu Tyr Asn Tyr Ala Ser Asp Lys Asp Tyr 130 135 140 Phe Ser Asp Leu Asp Ser Ser Pro Ile Ser Lys Thr Asp Leu Asn Leu 145 150 155 160 Arg Arg Ala Trp Glu Leu Asn Tyr Gln His Gly Ile Pro Gly Leu Lys 165 170 175 Ala Gln Leu Lys Val Glu Asp Phe Gln Thr Leu Asp Pro Gln Val Lys 180 185 190 Asp Ala Asp Lys Pro Tyr Ala Arg Leu Pro Gln Phe Leu Leu Asn Tyr 195 200 205 Val Thr Gly Asn Pro Leu Gly Leu Gln Tyr Glu Phe Asn Asn Asp Thr 210 215 220 Ala Tyr Phe Lys Lys Ser Ile Asn Asp Asn Ser Ala Gln Glu Ser Ser 225 230 235 240 Gly Thr Arg Ile Tyr Asn Gln Phe Ala Thr Arg Tyr Asn Tyr Arg Thr 245 250 255 Pro Ala Ala Phe Val Ile Pro Glu Val Ser Val Arg Ser Ile Gln Thr 260 265 270 Phe Tyr Asp Lys Asp Thr Gln Leu Asn Asn Pro Gly Gly Ser Glu Asn 275 280 285 Lys Ser Val Val Val Pro Gln Phe Thr Leu Asp Thr Gly Leu Asn Phe 290 295 300 Glu Arg Glu Gly Lys Tyr Leu Gln Thr Leu Thr Pro Arg Ala Phe Tyr 305 310 315 320 Ala Tyr Ala Pro Tyr Lys Asn Gln Asp Gly Tyr Pro Asn Phe Asp Ser 325 330 335 Thr Thr Ala Ser Ile Ser Tyr Asp Gln Leu Phe Asn Pro Tyr Arg Phe 340 345 350 Tyr Gly His Asp Arg Leu Glu Asp Asn Asn Phe Leu Ser Leu Gly Val 355 360 365 Ser Tyr Ser Leu Phe Asp Thr Val Gly Leu Glu Arg Leu Arg Ala Ser 370 375 380 Val Gly Gln Ser Tyr Tyr Phe Glu Asp Arg Arg Val Thr Leu Lys Gln 385 390 395 400 Gly Gln Asp Glu Phe Asp Thr Glu Arg Lys Thr Gly Pro Val Ile Ser 405 410 415 Leu Ser Ser Gln Leu Asn Gln Asn Phe Thr Ile Ala Ala Asn Ser Ala 420 425 430 Trp Met Ser Asn Gly Asp Asn Ala Gln Arg Asp Phe Gln Val Tyr Tyr 435 440 445 Thr Gly Asp Lys Gly Asn Leu Tyr Asn Leu Gly Tyr Phe Tyr Arg Lys 450 455 460 Asp Ile Pro Gly Arg Gln Asp Thr Tyr Asp Gln Val Val Ala Ser Phe 465 470 475 480 Ile Gln Pro Ile Lys Asp Asn Trp Arg Ile Met Gly His Val Gln Tyr 485 490 495 Asp Met Asp Asn Asp Val Ala Arg Glu Leu Leu Leu Gly Val Asn Tyr 500 505 510 Glu Ser Cys Cys Trp Gly Ile Ser Val Tyr Gly Arg Ser Tyr Tyr Asn 515 520 525 Asp Leu Asp Asp Pro Lys Thr Ser Asp Val Ser Glu Lys Arg Ala Ile 530 535 540 Met Ala Glu Ile Thr Leu Lys Gly Leu Gly Gly Leu Asn Asn Lys Leu 545 550 555 560 Ala Ser Leu Leu Glu Asn Arg Phe Leu Gly Phe Asn Lys Ile Asn Gln 565 570 575 Ser Trp Thr Gln Arg 580 <210> SEQ ID NO 36 <211> LENGTH: 747 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 36 Met Ser Ser Glu Lys Arg Asp Leu Thr Asn Phe Ser Arg Phe Leu Val 1 5 10 15 Asn Ile Asn Tyr Val Asp Phe Pro Glu Tyr Ala Lys Leu Pro Leu Ile 20 25 30 Gln Asn Phe Arg Asp Phe Lys His Phe Lys Thr Ala Ile Asp Trp Ser 35 40 45 Asn Lys Phe Asn Ile Gln Lys Ser Val Asp Gly Arg Ile Leu Leu Ser 50 55 60 Val Leu Tyr Ala Glu Ala Gln Asp Val Ala Asn Ala Lys Asp Gln Leu 65 70 75 80 Ser Lys Ile Asp Ile Lys Gly Leu Thr Ala Asp Gln Leu Val Arg Val 85 90 95 Ala Tyr Ala Tyr Arg Leu Ile Asn Leu Pro Val Asp Ala Leu Ala Thr 100 105 110 Val Glu His Ala Tyr Gln Gln Gln Pro Lys Ser Leu Ser Val Leu Gln 115 120 125 Glu Tyr Val Tyr Asp Leu Ile Ala Ile Gly Ser Tyr Lys Lys Ala Gln 130 135 140 Gln Leu Leu Gln Ala Ser Glu Lys Thr Glu Gln Thr Val Gln Met Leu 145 150 155 160 Lys Thr Leu Gln Val Ser Glu Phe Ser Gln His Ile Asn Asn Ala Ile 165 170 175 Ala Arg Tyr Lys Tyr Leu Asn Arg Glu Gly Leu Ser Asp Ala Glu Ser 180 185 190 Phe Ala Glu Leu Asp Lys Val Leu Glu Gln Gly Gln Lys Met His Gln 195 200 205 Gln Met Asn Pro Ser Asp Pro Asn Tyr Leu Arg Phe Tyr Tyr Asp Tyr 210 215 220 Leu Tyr Gly Leu Asp Phe Arg Gly Arg Ser Lys Ala Val Ile Glu Ser 225 230 235 240 Phe Thr Gln Leu Asn Ile Pro Leu Glu Lys Leu Pro Ala Tyr Val Arg 245 250 255 His Ala Ile Ala Asp Ser Tyr Leu Ala Glu Gln Lys Pro Lys Gln Ala 260 265 270 Glu Phe Ala Tyr Lys Thr Leu Leu Thr Glu Lys Asn Tyr Pro Asp Met 275 280 285 Thr Val Tyr Thr Gly Leu Tyr Tyr Ser Tyr Ile Glu Gln Glu Lys Tyr 290 295 300 Lys Glu Ala Glu Gln Leu Leu Ala Glu Val Asp Arg Leu Ile Pro Thr 305 310 315 320 Tyr Lys Tyr Ser Gln Ala Lys Gly Val Asp Lys Ile Ser His Pro Asp 325 330 335 Arg Asp Asp Tyr Ile Ala Leu Gln Gly Met His Leu Ala Tyr Ala Asn 340 345 350 His Leu Asp Gln Ala Glu Lys His Phe Gln Lys Lys Val Glu Gln Ala 355 360 365 Pro Ala Asn Glu Ser Leu Ile Asn Asn Leu Ala Arg Val Glu Arg Trp 370 375 380 Arg Glu Lys Pro Leu Glu Ala Lys Lys Thr Ile Ser Arg Leu Asn Gly 385 390 395 400 Ile Asp Pro Ile Ala Lys Asp Thr Arg Ile Asn Glu Met Gln Asn Ala 405 410 415 Gln Ala Leu Gly Asp Ile Pro Thr Trp Arg Lys Thr Thr Gln Asn Leu 420 425 430 Val Gln Tyr Tyr Pro Asp Asp Ser Gly Val Ile Lys Ser Arg Lys Glu 435 440 445 Leu Glu Asp Arg Asn Arg Ala Thr Ile Ser His Ser Thr Thr Trp Gly 450 455 460 Gln Ser Lys Ala Asp Gly Arg Asp Thr Val Ser Gly Gln Asn Gly Leu 465 470 475 480 Lys Asp Arg Glu Met Glu Thr Arg Leu Asn Ser Pro Trp Ile Asn Asp 485 490 495 Asn Tyr Arg Leu Phe Ala Trp His Gln Asp Arg Tyr Gly Glu Tyr Arg 500 505 510 Phe Gly Asp Val His Asp Gln Arg Tyr Gly Val Gly Ala Glu Trp Gln 515 520 525 Ala Asn Arg Lys Ala Leu Ser Ala Ile Val Ser Gln Ser Thr Asp Gly 530 535 540 Gly Gln Ala Gly Val Arg Leu Asp Trp Ser Gln Trp Leu Asn Asp His 545 550 555 560 Trp Gln Tyr Gln Leu Gln Tyr Asn Ser Gln Ala Asp Ile Pro Leu Gln 565 570 575 Ala Leu Asp Ala Gly Glu Asp Gly Gln Ser Tyr Arg Ala Ala Val Thr 580 585 590 Trp Gln Lys Asp Glu Ser Arg Gln Ile Gly Ala Ser Tyr Gly Leu Thr 595 600 605 Asp Ile Ser Asp Gly Asn Lys Gln Gln Glu Phe Ser Thr Phe Trp Arg 610 615 620 Glu Arg Leu Phe Asp Ala Pro His His Ile Thr Tyr Gly Thr Val Arg 625 630 635 640 Gly Phe Tyr Gly Thr Asn Ser Gln Asp Gln Thr Ala Tyr Phe Ser Pro 645 650 655 Ser Ser His Tyr Ser Ala Glu Leu Asn Leu Ser His Asp Trp Val Thr 660 665 670 Trp Arg Glu Tyr Glu Arg Ser Phe Lys Gln His Phe Glu Ala Gly Val 675 680 685 Gly Leu Tyr Lys Gln Ala Asp Tyr Ser Ala Lys Pro Thr Tyr Ser Leu 690 695 700 Gln Tyr Gln His Gln Trp Gln Leu Ser Arg Thr Trp Gln Leu Asn Tyr 705 710 715 720 Gly Ile Gly Trp Gln Tyr His Pro Tyr Asp Gly His Asp Glu Gln His 725 730 735 Thr Tyr Gly Ile Phe Gly Phe Glu Gly Arg Phe 740 745 <210> SEQ ID NO 37 <211> LENGTH: 381 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 37 Met Leu Gly Asp Trp Asn Gly Gln Arg Thr Ala Leu Gln Ala Gln Gly 1 5 10 15 Tyr Asp Phe Ser Phe Gly Tyr Thr Gly Glu Tyr Ala Gly Ile Leu Asp 20 25 30 Ser Lys Gln Thr Ser Thr His Gly Ser Ala Tyr Thr Gly Gln Leu Ala 35 40 45 Leu Gly Ser His Leu Asp Leu Gly Lys Ile Leu Gly Trp Gln Asp Thr 50 55 60 Glu Ala Gln Ile Thr Leu Thr Tyr Arg Asp Gly Gln Ser Leu Ser Glu 65 70 75 80 His Ser Pro Ala Leu Ala Gly His Gln Ser Ser Val Gln Glu Val Trp 85 90 95 Gly Arg Glu Gln Thr Trp Arg Leu Thr Asp Leu Trp Ile Lys Lys Lys 100 105 110 Phe Leu Asp Gln Lys Leu Asp Val Lys Val Gly Arg Phe Gly Glu Gly 115 120 125 Glu Asp Phe Asn Ser Phe Asp Cys Asp Phe Gln Asn Leu Ala Leu Cys 130 135 140 Gly Ser Gln Val Gly Asn Trp Val Gly Asp Gln Trp Tyr Asn Trp Pro 145 150 155 160 Val Ser Gln Trp Ala Met Arg Val Lys Tyr Asn Leu Gln Pro Asp Leu 165 170 175 Tyr Thr Gln Val Gly Val Tyr Glu Tyr Asn Pro Glu Asn Leu Glu Arg 180 185 190 Gly Lys Gly Phe Asn Leu Ser Thr Asp Gly Ser His Gly Ala Ile Ile 195 200 205 Pro Ala Glu Val Val Trp Ser Pro Lys Leu Gly Val Gln Ser Met Pro 210 215 220 Gly Glu Tyr Arg Leu Gly Tyr Tyr Tyr Ser Thr Ala Asp Ala Lys Glu 225 230 235 240 Ile Ala Asp Ser Thr Lys Thr Ser His Lys Gln Gly Val Trp Val Thr 245 250 255 Ala Lys Gln Lys Leu Phe Gln Pro Ala Asp Gln Thr Asp Arg Gly Leu 260 265 270 Thr Gly Phe Val Asn Leu Thr Phe His Asp Ser Asp Thr Asn Lys Val 275 280 285 Asp Asn Met Gln Asn Ile Gly Leu Val Tyr Lys Gly Leu Leu Asn Gln 290 295 300 Arg Pro Gln Asp Glu Leu Ala Leu Gly Val Ala Arg Ile His Ile Asn 305 310 315 320 Asp Asp Trp Ser Asp Val Gln Ala Lys Glu Tyr Asp Thr Glu Tyr Asn 325 330 335 Thr Glu Leu Tyr Tyr Gly Ile His Ala Thr Asn Trp Leu Thr Ile Arg 340 345 350 Pro Asn Val Gln Tyr Val Arg His Val Gly Ala Leu Lys Asn Gly Asp 355 360 365 Asn Thr Trp Val Gly Gly Ile Lys Phe Ser Thr Ala Phe 370 375 380 <210> SEQ ID NO 38 <211> LENGTH: 183 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 38 Met Leu Phe Arg Thr Gly Leu Ala Asp Gly Leu Glu Leu Gln Leu Gly 1 5 10 15 Trp Gln Gly Pro Ala Trp Thr Gln Thr Lys Arg Ala Gly Lys Lys Thr 20 25 30 Asp Asn Ser Gly Phe Gly Asp Val Ser Ile Gly Leu Lys Lys Ala Ile 35 40 45 Asp Leu Asn Asp Glu Asn Leu Thr Met Ala Val Leu Ala Glu Ala Val 50 55 60 Ile Ala Thr Gly Asn Asp Glu Phe Thr Ala His Asp Asp Ile Tyr Ser 65 70 75 80 Leu Ser Ser Ala Val Ala Tyr Lys Tyr Asn Asp Leu Leu Asp Thr Ser 85 90 95 Ile Thr Met Arg Tyr Glu Val Gln Asn Ser Asn Trp Ala Val Thr Ala 100 105 110 Ile Pro Thr Ile Asn Tyr Lys Ile Ala Gly Lys Leu Ser Gly Tyr Ser 115 120 125 Glu Phe Val Tyr Arg Lys Ala Glu Ser Gln Asp Tyr Gln Tyr Gly Leu 130 135 140 Gly Thr Gly Leu Val Tyr Ala Val Asn Asn Arg Thr Gln Leu Asp Ala 145 150 155 160 Asn Ile Gly Val Asp Leu Glu Gly Gln Asp Lys Ser Tyr Lys Gly Gly 165 170 175 Leu Gly Met Ala Phe Leu Phe 180 <210> SEQ ID NO 39 <211> LENGTH: 217 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 39 Met Arg Ala Leu Val Ile Ser Thr Val Val Gly Ala Ala Val Val Leu 1 5 10 15 Ser Gly Cys Gln Thr Thr Gly Asn Asn Leu Gly Gly Val Glu Tyr Asp 20 25 30 Lys Ala Ala Leu Gly Thr Leu Ile Gly Ala Ala Ala Gly Tyr Gly Ile 35 40 45 Ser Lys Ser Asn Ala Asn Ser Ser Arg Gln Asn Asn Arg Ala Ala Ala 50 55 60 Ile Gly Ala Val Leu Gly Ala Ala Gly Gly Leu Tyr Leu Asp Gln Lys 65 70 75 80 Glu Lys Lys Leu Arg Glu Gln Met Ala Gly Thr Gly Val Glu Val Gly 85 90 95 Arg Asn Pro Asp Gly Ser Val Gln Leu Ile Met Pro Gly Ser Ile Thr 100 105 110 Phe Asp Thr Asn Lys Ser Asn Ile Lys Pro Asn Phe Tyr Ala Thr Leu 115 120 125 Asp Lys Val Ala Gln Thr Leu Ala Glu Asp Asn Lys Ser Ala Ile Leu 130 135 140 Val Thr Gly Tyr Thr Asp Asn Thr Gly Asn Asp Ser Ile Asn Ile Pro 145 150 155 160 Leu Ser Gln Ala Arg Ala Gln Ser Val Lys Asn Tyr Leu Ala Gly Lys 165 170 175 Gly Val Pro Ser Ser Arg Ile Asp Ala Gln Gly Tyr Gly Ser Ser Asn 180 185 190 Pro Ile Ala Asp Asn Ser Thr Ala Ser Gly Arg Glu Gln Asn Arg Arg 195 200 205 Val Glu Ile Ser Ile Tyr Ala Lys Gln 210 215 <210> SEQ ID NO 40 <211> LENGTH: 299 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 40 Met Lys Lys Leu Gly Leu Ala Thr Ala Val Leu Leu Ala Met Thr Gly 1 5 10 15 Ala His Ala Tyr Gln Phe Glu Val Gln Gly Gln Ser Glu Tyr Val Asp 20 25 30 Thr Thr Ala Asn Asp Lys Asn Phe Thr Gly Asp Val Ala Gly Thr Phe 35 40 45 Tyr Leu Lys Asn Val Asp Thr Ala Lys Gly Pro Leu Ala Glu Ala Ala 50 55 60 Phe Leu Asn Gln Ala Ser Ser Val Ser Leu Gly Tyr Ser Tyr Gln Gln 65 70 75 80 Tyr Asp Gln Asn Asn Val Asn Tyr His Ile Gly Thr Tyr Gly Val Lys 85 90 95 Gly Glu Ala Tyr Val Pro Thr Pro Tyr Leu Pro Val Tyr Ala Ser Ala 100 105 110 Thr Tyr Asn His Thr Asp Val Asp Gly Lys Asn Asn Phe Ser Lys Asp 115 120 125 Asp Asn Gly Asp Arg Tyr Ala Leu Glu Val Gly Ala Met Leu Leu Pro 130 135 140 Asn Phe Leu Met Thr Val Gly Tyr Thr Ser Val Ala Asn Gln Phe Ala 145 150 155 160 Leu Asp Asn Phe Gly Ile Ile Gly Asn Gly Ile Tyr Ser Ala Val Asn 165 170 175 Gln Thr Ala Ala Ile Gln Asn Asp Gln Asp Ala Val Thr Ala Arg Ala 180 185 190 Lys Tyr Val Gly Pro Ile Asp Gly Thr Asn Met Ala Ile Gly Phe Glu 195 200 205 Ala Ala Gly Ala Phe Gly Gln Glu Asn Gln Tyr Gly Leu Lys Thr Asp 210 215 220 Leu Tyr Leu Thr Pro Lys Leu Ser Val Gly Ala Thr Phe Val Gly Asn 225 230 235 240 Asp Gly Glu Ala Asp Ile Lys Gly Asn Asp Leu Gly Glu Phe Arg Gln 245 250 255 Ala Trp Gly Gly Asn Val Asn Tyr Phe Ile Thr Pro Ala Leu Ala Val 260 265 270 Gly Ala Ser Tyr Met Lys Ala Asp Val Lys Lys Ser Ser Tyr Asp Thr 275 280 285 Gln Thr Ile Gly Leu Asn Ala Lys Phe Arg Phe 290 295 <210> SEQ ID NO 41 <211> LENGTH: 228 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 41 Asp Glu Ala Val Val His Asp Ser Tyr Ala Phe Asp Lys Asn Gln Leu 1 5 10 15 Ile Pro Val Gly Ala Arg Ala Glu Val Gly Thr Thr Gly Tyr Gly Gly 20 25 30 Ala Leu Leu Trp Gln Ala Asn Pro Tyr Val Gly Leu Ala Leu Gly Tyr 35 40 45 Asn Gly Gly Asp Ile Ser Trp Thr Asp Asp Val Ser Val Asn Gly Thr 50 55 60 Lys Tyr Asp Leu Asp Met Asp Asn Asn Asn Val Tyr Leu Asn Ala Glu 65 70 75 80 Ile Arg Pro Trp Gly Ala Ser Thr Asn Pro Trp Ala Gln Gly Leu Tyr 85 90 95 Ile Ala Ala Gly Ala Ala Tyr Leu Asp Asn Asp Tyr Asp Leu Ala Lys 100 105 110 Arg Ile Gly Asn Gly Asp Thr Leu Ser Ile Asp Gly Lys Asn Tyr Gln 115 120 125 Gln Ala Val Pro Gly Gln Glu Gly Gly Val Arg Gly Lys Met Ser Tyr 130 135 140 Lys Asn Asp Ile Ala Pro Tyr Leu Gly Phe Gly Phe Ala Pro Lys Ile 145 150 155 160 Ser Lys Asn Trp Gly Val Phe Gly Glu Val Gly Ala Tyr Tyr Thr Gly 165 170 175 Asn Pro Lys Val Glu Leu Thr Gln Tyr Asn Leu Ala Pro Val Thr Gly 180 185 190 Asn Pro Thr Ser Ala Gln Asp Ala Val Asp Lys Glu Ala Asn Glu Ile 195 200 205 Arg Asn Asp Asn Lys Tyr Glu Trp Met Pro Val Gly Lys Val Gly Val 210 215 220 Asn Phe Phe Trp 225 <210> SEQ ID NO 42 <211> LENGTH: 609 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 42 Met Gly Phe Asn Ser Ile Gln Ser Gly Gly Thr Asn Gly Asp Val Thr 1 5 10 15 Phe Arg Gly Met Phe Gly Ser Arg Ile Lys Ile Leu Thr Asp Gly Thr 20 25 30 Glu Asn Leu Gly Ala Cys Pro Asn Arg Met Asp Ala Pro Thr Ser Tyr 35 40 45 Ile Ser Pro Glu Ser Tyr Asp Arg Ile Ser Val Ile Lys Gly Pro Gln 50 55 60 Thr Val Gln Tyr Ala Asn Thr Gly Ser Ala Ala Thr Val Leu Phe Glu 65 70 75 80 Arg Gln Pro Glu Lys Leu Thr Ser Glu Lys Pro Tyr Arg Gly Gln Ala 85 90 95 Ser Val Leu Leu Gly Ser Tyr Gly Arg Ile Asp His Asn Ile Glu Ala 100 105 110 Ala Val Gly Asp Glu Lys Lys Tyr Ile Arg Leu Asn Ala Asn Arg Ser 115 120 125 Glu Ser Asn Ser Tyr Gln Asp Gly Asp Gly Asn Thr Val Pro Ser Ala 130 135 140 Trp Lys Lys Trp Asn Ala Asp Val Ala Leu Gly Phe Thr Pro Asp Glu 145 150 155 160 Asn Thr Trp Val Glu Ile Thr Gly Gly Lys Ser Asp Gly Glu Ser Leu 165 170 175 Tyr Ala Gly Arg Ser Met Asp Gly Ser Gln Phe Ala Arg Glu Ser Leu 180 185 190 Gly Leu Arg Phe Glu Lys Lys Asn Ile Thr Asp Val Ile Lys Lys Ile 195 200 205 Glu Gly Gln Val Asn Tyr Ser Tyr Asn Asp His Val Met Asp Asn Phe 210 215 220 Arg Leu Arg Ile Pro Pro Met Thr His Asp Met Met Thr His Gln Met 225 230 235 240 Val Val Asn Pro Ser Glu Met Gln Val Thr Arg Arg Thr Leu Asn Thr 245 250 255 Arg Phe Ala Met Thr Ser Glu Trp Gly Lys Leu Asn Val Ile Thr Gly 260 265 270 Ile Asp Ser Gln Gln Asn His His Ala Glu Ser Met Lys Ser Leu Met 275 280 285 Met Asp Met Pro Leu Thr Thr Asn Met Lys Phe Gln Ser Tyr Gly Ala 290 295 300 Phe Gly Glu Leu Gly Tyr Gln Leu Ser Glu Asn Ser Lys Leu Val Thr 305 310 315 320 Gly Ala Arg Leu Asp Gln Val Lys Ile Asp Ala Leu Lys Leu Asn Asp 325 330 335 Asp Arg Ser Glu Thr Leu Pro Ser Gly Phe Ile Arg Leu Glu Thr Gln 340 345 350 Leu Pro Glu His Asn Ala Lys Ser Tyr Ile Gly Leu Gly Tyr Val Glu 355 360 365 Arg Val Pro Asp Tyr Trp Glu Leu Phe Ser Thr Ala His Gly Asn Ser 370 375 380 Gly Met Pro Lys Pro Thr Phe Asn Asp Leu Asp Thr Glu Lys Thr Leu 385 390 395 400 Gln Leu Asp Met Gly Tyr Gln His Gln His Gly Ala Phe Asn Ser Trp 405 410 415 Ala Ser Ala Tyr Val Gly Leu Ile Asn Asp Tyr Ile Leu Met Ser Tyr 420 425 430 His Asn His Pro Thr Ser Gly Gly His Gly His Gly Ser Ser Phe Ser 435 440 445 Ala Gly Ala Lys Asn Val Asp Ala Thr Ile Ala Gly Ala Glu Ala Gly 450 455 460 Ile Gly Tyr Gln Phe Thr Asp Arg Ile Gln Ala Asp Leu Ser Ala Met 465 470 475 480 Tyr Ala Trp Gly Lys Asn Thr Thr Asp Asp Lys Pro Leu Pro Gln Ile 485 490 495 Ser Pro Leu Glu Gly Arg Leu Asn Ile Arg Tyr Val Ala Asp Lys Tyr 500 505 510 Asn Leu Gly Leu Leu Trp Arg Ala Val Ala Glu Gln Asn Arg Val Ser 515 520 525 Leu His Gln Gly Asn Ile Val Gly Tyr Asp Leu Lys Pro Ser Lys Gly 530 535 540 Phe Ser Thr Leu Ser Leu Asn Gly Ser Tyr Asn Leu Arg Lys Asp Ile 545 550 555 560 Asp Val Ser Val Gly Ile Asp Asn Val Leu Asp Lys Thr Tyr Thr Glu 565 570 575 His Leu Asn Lys Ala Gly Ser Ala Gly Phe Gly Phe Ala Ser Glu Glu 580 585 590 Gln Phe Asn Asn Ile Gly Arg Asn Tyr Trp Val Arg Met Ser Met Lys 595 600 605 Phe <210> SEQ ID NO 43 <211> LENGTH: 170 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 43 Met Thr Gly Cys Ala Ser Arg Lys Pro Ala Thr Thr Ala Thr Thr Gly 1 5 10 15 Thr Thr Asn Pro Ser Thr Val Asn Thr Thr Gly Leu Ser Glu Asp Ala 20 25 30 Ala Leu Asn Ala Gln Asn Leu Ala Gly Ala Ser Ser Lys Gly Val Thr 35 40 45 Glu Ala Asn Lys Ala Ala Leu Ala Lys Arg Val Val His Phe Asp Tyr 50 55 60 Asp Ser Ser Asp Leu Ser Thr Glu Asp Tyr Gln Thr Leu Gln Ala His 65 70 75 80 Ala Gln Phe Leu Met Ala Asn Ala Asn Ser Lys Val Ala Leu Thr Gly 85 90 95 His Thr Asp Glu Arg Gly Thr Arg Glu Tyr Asn Met Ala Leu Gly Glu 100 105 110 Arg Arg Ala Lys Ala Val Gln Asn Tyr Leu Ile Thr Ser Gly Val Asn 115 120 125 Pro Gln Gln Leu Glu Ala Val Ser Tyr Gly Lys Glu Ala Pro Val Asn 130 135 140 Pro Gly His Asp Glu Ser Ala Trp Lys Glu Asn Arg Arg Val Glu Ile 145 150 155 160 Asn Tyr Glu Ala Val Pro Pro Leu Leu Lys 165 170 <210> SEQ ID NO 44 <211> LENGTH: 480 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 44 Met Phe Leu Arg Lys Thr Leu Ser Ile Ala Leu Leu Ala Thr Ala Ser 1 5 10 15 Ser Ala Val Phe Ala Gln Gly Leu Val Leu Asn Asn Asp Asp Leu Arg 20 25 30 Thr Asp Leu Asn Trp Leu Asn Gln Gln Gly Val Ile Asn Ile Ser Thr 35 40 45 Ser Thr Trp Pro Leu Ser Gly Asp Glu Ile Gln Arg Ala Leu Ser Gln 50 55 60 Ala Lys Val Thr His Pro Ala Gln Gln Lys Val Ile Asn Ser Val Leu 65 70 75 80 Asn Ala Leu Lys Ala Asp Asn Asn Thr Val Lys Val Gly Ala Phe Ala 85 90 95 Glu Ser Asp Ile Lys Asn Ile Pro Gln Ala Phe Gly Asp Asn Gln Lys 100 105 110 Ser Gln Tyr Gln Gly Ser Leu Glu Phe Asn Ala Gly Gly Glu Asn Trp 115 120 125 Asp Ala Lys Ile Arg Val Asn Ala Glu Lys Asp Pro Gln Ile Asp Ser 130 135 140 Gly His Asp Val Asn Val Glu Gly Ser Tyr Val Ala Gly Lys Leu Trp 145 150 155 160 Asn Gln Trp Ile Val Ala Gly Gln Ile Pro Thr Trp Trp Gly Pro Gly 165 170 175 His Asp Gly Ser Leu Ile Arg Gly Asp Ala Ser Arg Pro Val Tyr Gly 180 185 190 Val Thr Ala Gln Arg Ala Val Gln Asn Ala Phe Glu Thr Lys Trp Leu 195 200 205 Ser Trp Ile Gly Pro Trp Gln Tyr Gln Ala Phe Ala Gly Gln Leu Asp 210 215 220 Asp Tyr Lys Ala Val Pro Asp Ala Lys Leu Ile Gly Leu Arg Leu Thr 225 230 235 240 Ala Gln Pro Leu Pro Tyr Leu Glu Leu Gly Ala Ser Arg Thr Ile Gln 245 250 255 Trp Gly Gly Asp Gly Arg Ser Glu Ser Phe Ser Ser Leu Trp Asp Ala 260 265 270 Ile Lys Gly Asn Asp Asn Val Tyr Gly Asp Thr Glu Asn Pro Ser Asn 275 280 285 Gln Leu Ala Gly Phe Asp Gly Arg Leu Leu Leu Gln Pro Leu Leu Asn 290 295 300 Ile Pro Val Ser Leu Tyr Gly Gln Tyr Val Gly Glu Asp Glu Ala Gly 305 310 315 320 Tyr Leu Pro Ser Lys Lys Met Tyr Leu Ala Gly Val Asp Tyr Ser Ser 325 330 335 Ser Tyr Asn Asp Met Pro Tyr Gln Leu Tyr Ala Glu Trp Ala Asp Thr 340 345 350 Arg Thr Asn Gly Asp Val Lys Ser Ile Ser Tyr Thr His Ser Val Tyr 355 360 365 Lys Asp Gly Tyr Tyr Gln His Gly Phe Pro Leu Gly His Ala Met Gly 370 375 380 Gly Asp Gly Gln Met Tyr Ser Val Gly Gly Asp Ile Arg Phe Asp Val 385 390 395 400 Met Asn Arg Leu Ser Gly Arg Ala Met Val Val Lys Val Asn Gln Ser 405 410 415 Asn Leu Ala Ile Asn Lys Ala Phe Pro Lys Asp Asp Glu Ile Lys Ala 420 425 430 Leu Asp Leu Thr Trp Thr His Tyr Ile Lys Pro Asp Leu Pro Leu Lys 435 440 445 Ile Asn Gly Trp Val Ser Asp Ser Asp Leu Glu Gly Asn Asp Ala Gly 450 455 460 Ala Ser Ile Gly Val Glu Ile Pro Leu Glu Arg Lys Met Phe Gly Phe 465 470 475 480 <210> SEQ ID NO 45 <211> LENGTH: 114 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 45 Met Asn Lys Leu Leu Val Ala Leu Gly Leu Ala Ala Thr Val Ala Leu 1 5 10 15 Val Gly Cys Asn Lys Asp Lys Ala Pro Glu Thr Gly Ala Thr Thr Gly 20 25 30 Glu His Leu Glu Asn Ala Ala Gln Gln Ala Thr Ala Asp Ile Lys Ser 35 40 45 Ala Gly Asp Gln Ala Ala Ser Asp Ile Ala Thr Ala Thr Asp Asn Ala 50 55 60 Ser Ala Lys Ile Asp Ala Ala Ala Asp His Ala Ala Asp Ala Thr Ala 65 70 75 80 Lys Ala Ala Ala Glu Thr Glu Ala Thr Ala Arg Lys Ala Thr Ala Asp 85 90 95 Thr Ala Gln Ala Val Glu Asn Ala Ala Ala Asp Val Lys Lys Asp Ala 100 105 110 Gln His <210> SEQ ID NO 46 <211> LENGTH: 725 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 46 Met Tyr Glu Tyr Pro Ser Tyr Asp Tyr Arg Gly Asn Phe Lys Ile Thr 1 5 10 15 Val Asp Pro Ser Gln Ile Lys Gln Asn Val Lys Ala Glu Asn Thr Ala 20 25 30 Lys Leu Asp Ala Glu Leu Gln Lys Lys Val Asp Gln Tyr Leu Arg Glu 35 40 45 Gln Lys Val Ala Leu Ser Lys Ala Gln Lys Gln Thr Leu Tyr Ala Ala 50 55 60 Ile Ala Asn Glu Gln Gly Asp Trp Gly Leu Thr Ser Ser Ala Arg Ser 65 70 75 80 Glu Lys Ile Asn Asn Ile Leu Ile Asn Leu Leu Asn Asp Leu Gln Phe 85 90 95 Ser Tyr Asp Gly Ser Ile His Tyr Arg Gln Lys Met Gly Ser Phe Asn 100 105 110 Leu Thr Ala Arg Tyr Glu Lys Pro Thr Leu Leu Val Gln Ala Lys Leu 115 120 125 Pro Met Val Leu Asp Leu Glu Asn Tyr Lys Phe Tyr Ile Asn Tyr Phe 130 135 140 Gly Leu Met Pro Tyr Leu Val Asn Lys Asp Asn Gln Asn Asn Leu Ala 145 150 155 160 Tyr Val Asp Phe Ser Lys Tyr Lys Ala Phe Phe Lys Asn Val Asp Lys 165 170 175 Lys Lys Phe Ile Glu Tyr Leu Lys Ala Ser Ser Ala Val Ser Tyr Arg 180 185 190 Leu Ala Glu Pro Gln Asn Leu Gln Arg Val Ser Leu Thr Glu Ala Asp 195 200 205 Arg Lys Ala Gly Ala Val Glu Arg Ile Arg Leu Lys Thr Thr Val Glu 210 215 220 Gln Leu Leu Leu Glu Val Asp Leu Phe Gly Gln Val Asn Glu Lys Tyr 225 230 235 240 Leu Gln Lys Ser Val Leu Gly Leu Asp Glu Glu Lys Leu Ala Glu Thr 245 250 255 Leu Ala Ala Glu Ile Ala Ala Ser Asp Ala Lys Lys Gly Thr Ala Gly 260 265 270 Lys Glu Glu Gln Lys Val Ser Ser Asp Asp Ala Ala Ala Val Ser Gln 275 280 285 Gln Leu Tyr Ser Leu Val Asn Ala His Leu Gly Asn Thr Ser Thr Ser 290 295 300 Glu Asp Glu Glu Val Glu Ser Ala Ser Ser Glu Glu Ala Ser Asp Val 305 310 315 320 Ala Val Ala Glu Ala Glu Gln Thr Ser Glu Asn Glu Glu Val Val Val 325 330 335 Leu Thr Glu Asp Gln Cys Ile Glu Leu Lys Ser Leu Lys Asn Pro Val 340 345 350 Ala Leu Gly Asp Ile Asn Tyr Cys Gln Ile Tyr Gly Ile Asp Val Leu 355 360 365 Asp Gln Ser Asp Thr Ser Ile Gln Lys Ala Gln Ile Lys Ser Arg Gln 370 375 380 Asp Ala Leu Lys Gln Thr Phe Glu Val Tyr Asn Gln Asn Gln Phe Ile 385 390 395 400 Asn Asp Glu Ala Phe Lys Val Leu Trp Leu Lys His Lys Asp Glu Ile 405 410 415 Glu Gln Ala Leu Pro Lys Gln Arg Asn Pro Ile Thr Ile Asp Val Ala 420 425 430 Leu Asp Asp Lys Gly Arg Ala Val Asn Met Asp Tyr Asp Val Asp Tyr 435 440 445 Thr Pro Ala Glu Phe Lys His Arg Phe Asn Ile Lys Ala Asp Met Gln 450 455 460 Ile Leu Asn Tyr Gly Lys Ala Thr Ser Ile Asp Gln Gln Gln Leu Lys 465 470 475 480 Gln Ala Lys Ser Val Ala Glu Ala Ser Lys Gly Ser Met Leu Glu Asn 485 490 495 Ile Ile Lys Gly Phe Ser Glu Lys Leu Gly Gln Ser Asp Val Ser Glu 500 505 510 His Pro Val Gly Thr His Ser Asp Val Gln Asp Leu Asp Ala Asn Leu 515 520 525 Ala Ile Leu Ala Asp Lys Thr Tyr Asp Ala Thr His Ala Tyr Asp Lys 530 535 540 Thr Tyr Lys Ala Val Phe Ile Ala Lys Leu Thr Ala Glu Lys Pro Ser 545 550 555 560 Tyr Ile Lys Tyr Tyr Ser Val Gln Gln Leu Gln Glu Ile Ala Glu Val 565 570 575 Tyr Ala Tyr Trp Phe Ser Asp Glu Asp Thr Tyr Asn Pro Gln Gly Lys 580 585 590 Ala Leu Glu Arg Ile Thr Ala Leu Gln Lys Lys His His Leu Glu Gln 595 600 605 Asp Asp Gln Phe Asp His Glu Leu Gly Arg Ala Val Asp His Ile Val 610 615 620 Leu Thr Thr Ile Gln Gly Lys Thr Gly Arg Glu Ala Trp Gln Arg Leu 625 630 635 640 Gln Lys Gln Tyr Lys Gln Pro Ala Gln Leu Phe Ser Lys Gln Tyr Gln 645 650 655 Leu Glu Phe Glu Lys Gln Asn Gly Val Ser Ala Glu Glu Lys His Leu 660 665 670 Leu Ser Glu Thr Ala Asp Ile Leu Gly Asn Val Tyr Val Ala Ala His 675 680 685 Lys Lys Gln Leu Ser Glu Lys Thr Ile Gln Asn Leu Lys Pro Glu His 690 695 700 Asn Glu Phe Ile Asp Tyr Glu Ile Phe Arg Glu Val Tyr Lys Gln Met 705 710 715 720 Val Ala Ala Arg Lys 725 <210> SEQ ID NO 47 <211> LENGTH: 746 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 47 Met Thr Pro Cys Cys Leu Ala Ile Ser Ala Ile Phe Ala Gln Gln Ala 1 5 10 15 Tyr Ala Glu Thr Val Thr Gln Thr Ala Glu Val Ser Glu Asn Ala Thr 20 25 30 Gln Lys Pro Val Ala Gln Leu Gln Lys Ile Val Val Thr Ala Thr Arg 35 40 45 Thr Pro Lys Asn Ile Ala Glu Ile Ala Gly Thr Val Gln Ser Ile Asp 50 55 60 Gln Lys Gln Ile Ile Gln Gln Ala Thr Ala Gly Arg Lys Val Ala Asp 65 70 75 80 Ile Leu Ala Gln Leu Val Pro Ser Leu Ala Ser Ser Ser Gly Thr Thr 85 90 95 Ser Asn Tyr Gly Gln Thr Met Arg Gly Arg Asn Val Leu Val Met Ile 100 105 110 Asp Gly Val Ser Gln Thr Gly Ser Arg Asp Val Ser Arg Gln Leu Asn 115 120 125 Ser Ile Ser Pro Gly Met Ile Glu Arg Ile Glu Val Ile Ser Gly Ala 130 135 140 Thr Ser Ile Tyr Gly Ser Gly Ala Thr Gly Gly Ile Ile Asn Ile Ile 145 150 155 160 Thr Lys Arg Ala Asp Thr Ser Lys Pro Leu Ser Phe Glu Thr Lys Val 165 170 175 Gly Ile Thr Ser Ser Asp Thr Phe Arg Ser Asp Gly Leu Ala Tyr Glu 180 185 190 Val Gly Gln Ser Val Ser Phe Asn Lys Gly Asn Ile Asp Gly Phe Leu 195 200 205 Gly Ala Asn Phe Thr Ser Arg Gly Ser Gln Phe Asp Gly Asn Gly Asp 210 215 220 Arg Ile Ser Leu Ser Pro Trp Gln Gly Ser Thr Met Asp Thr Asp Thr 225 230 235 240 Ile Asp Val Asn Gly Arg Leu Asn Phe Asn Leu Asn Asp Thr Gln Thr 245 250 255 Leu Ser Phe Gly Ala Gln Tyr Tyr Lys Asp Lys Gln Asp Thr Asp Tyr 260 265 270 Gly Pro Asp Tyr Ser Tyr Leu Pro Thr Thr Ser Lys Ser Asn Asp Ala 275 280 285 Thr Thr Pro Thr Tyr Lys Ala Ile Lys Gly Leu Lys Leu Ser Asn Pro 290 295 300 Leu Phe Thr Glu Arg Tyr Ala Val Asn Ser Gln Tyr Gln Asn Gln Asp 305 310 315 320 Phe Leu Gly Gln Ile Leu Asn Val Glu Ala Tyr Tyr Arg Asn Glu Lys 325 330 335 Ser Arg Phe Phe Pro Tyr Gly Leu Ser Asn Lys Ser Val Thr Ser Val 340 345 350 Asn Gln Ser Gln Ser Glu Ile Glu Val Ala Gly Leu Arg Ser Thr Met 355 360 365 Gln Thr Asp Leu Asn Ile Ala Asn Arg Asp Met Lys Ile Thr Tyr Gly 370 375 380 Leu Asp Tyr Asp Trp Glu Lys Asp Lys Gln Phe Val Asp Ile Leu Ala 385 390 395 400 Thr Gln Tyr Pro Tyr Leu Val Tyr Thr Pro Thr Gly Gln Arg Lys Gly 405 410 415 Tyr Gly Pro Asn Thr Glu Ile Gln Asn Ile Gly Ala Phe Val Gln Ser 420 425 430 Asp Tyr Ala Val Thr Asp Lys Leu Asn Leu Gln Ala Gly Ile Arg Tyr 435 440 445 Gln Tyr Ile Gln Ala Asp Thr Asp Ala Tyr Ile Pro Ser Arg Glu Thr 450 455 460 Thr Met Val Pro Ala Gly Ser Thr His Asp Asp Lys Pro Leu Phe Asn 465 470 475 480 Leu Gly Ala Val Tyr Lys Leu Thr Asp Ala Gln Gln Val Tyr Ala Asn 485 490 495 Phe Ser Gln Gly Phe Ser Phe Pro Asp Val Gln Arg Met Leu Arg Asp 500 505 510 Val Ser Thr Tyr Thr Val Ser Thr Ala Asn Leu Gln Pro Ile Thr Val 515 520 525 Asn Ser Tyr Glu Leu Gly Trp Arg Leu Asn Gln Asp Asp Gly Leu Asn 530 535 540 Leu Gly Leu Thr Gly Phe Tyr Asn Thr Ser Asp Lys Thr Val Gln Phe 545 550 555 560 Asn Asn Arg Ala Ala Lys Val Val Asp Thr Asp Gln Arg Val Tyr Gly 565 570 575 Ala Glu Ala Thr Ile Ser Tyr Pro Phe Met Glu Asn Tyr Lys Val Gly 580 585 590 Gly Thr Leu Gly Tyr Thr Arg Gly Gln Tyr Lys Asp Val Ala Asn Lys 595 600 605 Trp His Glu Leu Asn Ser Phe Thr Val Ala Pro Val Lys Gly Thr Leu 610 615 620 Phe Ala Glu Trp Asp Asn Asn Glu Gly Tyr Gly Val Arg Val Gln Met 625 630 635 640 Gln Ala Ile Lys Gly Thr Asn Lys Ala Tyr Lys Asp Asp Arg Glu Leu 645 650 655 Ala Ala Phe Ala Thr Thr Gln Asp Glu Ala Phe Gln Asn Ala Val Lys 660 665 670 Asn Asp Ala Asn Ser Ala Ala Gln Ile Lys Gly Tyr Thr Thr Met Asp 675 680 685 Val Leu Ala His Phe Pro Ala Trp Lys Gly Arg Val Asp Phe Gly Val 690 695 700 Tyr Asn Val Trp Asn Arg Gln Tyr Arg Thr Val Phe Ala Gln Gln Ala 705 710 715 720 Ala Val Ser Asn Ala Asn Pro Leu Leu Ala Ile Pro Ala Glu Gly Arg 725 730 735 Thr Tyr Gly Leu Ser Tyr Thr Phe Asn Tyr 740 745 <210> SEQ ID NO 48 <211> LENGTH: 476 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 48 Met Gly Ala Gln Leu Val Arg Glu Val Ser Ser Lys Thr Asn Asp Ile 1 5 10 15 Ala Gly Asp Gly Thr Thr Thr Ala Thr Val Leu Ala Gln Ala Ile Leu 20 25 30 Asn Glu Gly Ile Lys Ser Val Thr Ala Gly Met Asn Pro Met Asp Leu 35 40 45 Lys Arg Gly Ile Asp Ile Ala Val Lys Thr Val Val Glu Asn Ile Arg 50 55 60 Ser Ile Ala Lys Pro Ala Asp Asp Phe Lys Ala Ile Glu Gln Val Gly 65 70 75 80 Ser Ile Ser Ala Asn Ser Asp Thr Thr Val Gly Lys Leu Ile Ala Gln 85 90 95 Ala Met Glu Lys Val Gly Lys Glu Gly Val Ile Thr Val Glu Glu Gly 100 105 110 Ser Gly Phe Glu Asp Ala Leu Asp Val Val Glu Gly Met Gln Phe Asp 115 120 125 Arg Gly Tyr Ile Ser Pro Tyr Phe Ala Asn Lys Gln Asp Thr Leu Thr 130 135 140 Ala Glu Leu Glu Asn Pro Phe Ile Leu Leu Val Asp Lys Lys Ile Ser 145 150 155 160 Asn Ile Arg Glu Leu Ile Ser Val Leu Glu Ala Val Ala Lys Thr Gly 165 170 175 Lys Pro Leu Leu Ile Ile Ala Glu Asp Val Glu Gly Glu Ala Leu Ala 180 185 190 Thr Leu Val Val Asn Asn Met Arg Gly Ile Ile Lys Val Cys Ala Val 195 200 205 Lys Ala Pro Gly Phe Gly Asp Arg Arg Lys Ala Met Leu Gln Asp Ile 210 215 220 Ala Ile Leu Thr Gly Ala Thr Val Ile Ser Glu Glu Val Gly Met Ser 225 230 235 240 Leu Glu Gln Ala Thr Leu Gln Asp Leu Gly Thr Ala His Lys Ile Thr 245 250 255 Val Ser Lys Glu Asn Thr Val Ile Val Asp Gly Ala Gly Asp Ala Ala 260 265 270 Ala Ile Ala Glu Arg Val Gln Gln Ile Arg Ala Gln Ile Glu Glu Ser 275 280 285 Thr Ser Glu Tyr Asp Arg Glu Lys Leu Gln Glu Arg Val Ala Lys Leu 290 295 300 Ala Gly Gly Val Ala Val Ile Lys Ile Gly Ala Ala Thr Glu Val Glu 305 310 315 320 Met Lys Glu Lys Lys Asp Arg Val Asp Asp Ala Leu His Ala Thr Arg 325 330 335 Ala Ala Val Glu Glu Gly Val Val Ala Gly Gly Gly Val Ala Leu Val 340 345 350 Arg Ala Val Asn Ala Leu Glu Gly Leu Lys Gly Ala Asn Glu Asp Gln 355 360 365 Thr Ala Gly Ile Asn Ile Leu Arg Arg Ala Ile Glu Ala Pro Leu Arg 370 375 380 Gln Ile Val Ala Asn Ala Gly Asp Glu Pro Ser Val Val Ile Asn Ala 385 390 395 400 Val Lys Asn Gly Glu Gly Asn Phe Gly Tyr Asn Ala Ala Thr Gly Glu 405 410 415 Tyr Gly Asp Met Leu Glu Met Gly Ile Leu Asp Pro Ala Lys Val Thr 420 425 430 Arg Ser Ala Leu Glu His Ala Ala Ser Val Ala Gly Leu Met Leu Thr 435 440 445 Thr Glu Cys Met Ile Thr Asp Ile Pro Glu Asp Lys Pro Ala Ala Pro 450 455 460 Asp Met Gly Gly Met Gly Gly Met Gly Gly Met Met 465 470 475 <210> SEQ ID NO 49 <211> LENGTH: 472 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 49 Met Ser Ala Phe Phe Gln Pro Gly Asn Tyr Phe Glu Ala Gly Ile Ser 1 5 10 15 Val Leu Asp Pro Asp Val Ala Gly Lys Glu Ala Gly Ser Ser Ala Thr 20 25 30 Arg Arg Asp Ile Gly Asp Met Ala Asn Asp Tyr Tyr Phe Pro Ser Ala 35 40 45 Ala Leu Lys Leu Gln Ile Asn Asp Gln Phe Ser Phe Gly Leu Leu Tyr 50 55 60 Asp Gln Pro Phe Gly Ala Asp Ala Glu Tyr Ser Gly Asn Asn Val Phe 65 70 75 80 Val Ser Asn Pro Gly Ser Asp Thr Ile Leu Ser Gln Lys Ala Leu Gly 85 90 95 Asp Leu Ala Thr Ser Ser Ile Gln Lys Leu Val Gln Ala Ser Gly Ser 100 105 110 Ala Phe Thr Pro Ala Leu Ile Glu Val Thr Lys Val Thr Gly Gly Asp 115 120 125 Pro Thr Lys Pro Thr Gln Thr Glu Ile Leu Gly Ala Leu Gln Gln Val 130 135 140 Ala Ala Gly Gly Asn Thr Thr Val Gly Ala Gly Leu Thr Ala Leu Gln 145 150 155 160 Lys Thr Gln Ala Ala Ile Asn Ala Ala Asn Asn Tyr Leu Gly Thr Gly 165 170 175 Gly Thr Lys Val Lys Val Asp Thr Gln Asn Leu Ser Phe Val Phe Gly 180 185 190 Tyr Gln Pro Thr Lys Asn Phe Asn Phe Tyr Ala Gly Pro Val Leu Gln 195 200 205 Thr Val Lys Gly Asn Val Ser Leu Arg Gly Gln Ala Tyr Ser Leu Tyr 210 215 220 Asn Gly Tyr Asp Ala Asn Ile Lys Glu Thr Thr Gly Ala Gly Trp Leu 225 230 235 240 Ala Gly Ala Ala Tyr Gln Ile Pro Glu Ile Ala Leu Arg Ala Ser Val 245 250 255 Thr Tyr Arg Ser Glu Ile Asp His Lys Val Asn Ile Asp Glu Asn Leu 260 265 270 Ser Ile Leu Asn Phe Pro Gly Leu Thr Ser Val Leu Ala Gly Leu Asp 275 280 285 Val Pro Ala Ser Lys Leu Gln Ala Ile Asn Ser Ser Gly Lys Thr Thr 290 295 300 Ile Thr Thr Pro Gln Ser Val Asn Leu Asp Phe Gln Thr Gly Ile Met 305 310 315 320 Ala Asp Thr Val Ala Phe Ala Asn Val Arg Trp Val Asn Trp Lys Asp 325 330 335 Phe Ser Ile Gln Pro Tyr Lys Phe Gly Lys Val Ser Glu Ala Val Gly 340 345 350 Gly Leu Ile Gly Arg Pro Asn Gly Phe Asn Leu Val Glu Tyr Ser Asp 355 360 365 Asp Gln Trp Ser Val Asn Ala Gly Val Gly Arg Lys Leu Asn Asp Lys 370 375 380 Trp Ala Gly Asn Val Ser Val Gly Trp Asp Ser Gly Ala Gly Asn Pro 385 390 395 400 Val Thr Thr Leu Gly Pro Thr Glu Gly Tyr Trp Asn Val Gly Leu Gly 405 410 415 Val Gln Tyr Ser Pro Thr Pro Gln Thr Phe Ile Ala Gly Gly Val Lys 420 425 430 Tyr Phe Trp Leu Gly Asp Ala Lys Ala Gln Thr Gly Ala Gln Ala Gly 435 440 445 Ser Asp Glu Tyr Val Ala Asp Phe Ser Asp Asn Asn Ala Ile Ala Tyr 450 455 460 Gly Leu Lys Leu Gly Tyr Lys Phe 465 470 <210> SEQ ID NO 50 <211> LENGTH: 216 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 50 Met Val Phe Ala Gln Asp Asp Asn Ala Leu His Tyr Asn Ile Val Asn 1 5 10 15 Val Gln Ala Glu Ala Ser Arg Gln Val Ser Asn Asp Glu Met His Ala 20 25 30 Thr Leu Tyr Ile Glu Lys Ser Asn Lys Gln Pro Ala Glu Leu Ser Asn 35 40 45 Gln Ile Asn Gln Leu Met Asn Gln Ala Leu Ala Thr Ser Arg Lys Tyr 50 55 60 Pro Gln Val Lys Val Glu Thr Gly Ala Gln Ser Thr Tyr Pro Ile Tyr 65 70 75 80 Asp Asn Asp Ser Asn Lys Leu Lys Glu Trp Arg Gly Arg Ala Glu Ile 85 90 95 Arg Leu Glu Ser Lys Asp Phe Lys Ala Ala Ser Gln Leu Ile Asn Glu 100 105 110 Leu Gln Gln Ser Phe Gln Thr Gln Ser Ile Asn Phe Ser Val Ser Asp 115 120 125 Glu Gln Arg Lys Lys Val Glu Asn Glu Leu Met Val Glu Ala Ser Lys 130 135 140 Asn Phe Gln Gln Arg Ala Gln Met Leu Thr Gln Ala Trp Asn Lys Ser 145 150 155 160 Gln Tyr Ser Leu Val Thr Leu Asn Leu Asn Thr Asn Asn Tyr Phe Pro 165 170 175 Gln Pro Val Met Arg Ala Ser Leu Ala Lys Phe Ala Ala Ala Glu Ala 180 185 190 Ala Pro Ala Gln Asp Met Ala Ala Gly Glu Ser Lys Ile Thr Val Asn 195 200 205 Ala Asn Gly Ser Ile Gln Phe Lys 210 215 <210> SEQ ID NO 51 <211> LENGTH: 366 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 51 Met Lys Tyr Cys Gln Phe Phe Ser Val Leu Ala Leu Ser Leu Ser Ala 1 5 10 15 Ala Ser Cys Ala Val Thr Ser Gly Leu Gln Thr Tyr Asp Ile Pro Ser 20 25 30 Glu Gly Val Tyr Lys Thr Asp Leu Gly Thr Thr Val Asn Val Val Lys 35 40 45 Ile Ser Gln Glu Thr Leu Pro Ala Ile Gln Pro Ala Gln Ile Asp Tyr 50 55 60 Gln Arg Asp Tyr Ala Ser Leu Phe Lys Asn Gln Gln Ser Ile Tyr Arg 65 70 75 80 Leu Ser Pro Gly Asp Val Leu Ser Ile Gln Leu Trp Ala Tyr Pro Glu 85 90 95 Ile Thr Pro Pro Val Asn Asn Ile Ser Asn Glu Gln Ser Ile Gln Ala 100 105 110 Asn Gly Tyr Pro Ile Asp Gln Ser Gly Tyr Ile Gln Phe Pro Leu Val 115 120 125 Gly Arg Tyr Lys Ala Ala Gly Lys Thr Leu Ala Gln Val Asn Arg Glu 130 135 140 Leu His Ser Gln Leu Ala Arg Phe Leu Lys Asn Pro Asp Val Val Val 145 150 155 160 Arg Val Val Ser Tyr Glu Gly Gln Arg Phe Ser Val Gln Gly Ser Val 165 170 175 Thr Lys Gly Gly Gln Phe Tyr Leu Ser Asp Gln Pro Val Ser Ile Tyr 180 185 190 Thr Ala Leu Gly Met Ala Gly Gly Val Thr Thr Thr Gly Asp Asn Thr 195 200 205 Tyr Ile Gln Leu Ile Arg Asn Gly Arg Thr Tyr Asn Leu Asn Thr Ile 210 215 220 Asp Leu Glu Lys Ala Gly Tyr Ser Leu His Lys Leu Leu Val Gln Pro 225 230 235 240 Asn Asp Thr Ile Tyr Val Ser Thr Arg Glu Asn Gln Lys Ile Tyr Val 245 250 255 Met Gly Glu Ser Gly Lys Asn Gln Ala Leu Pro Met Arg Asp Gln Gly 260 265 270 Met Thr Leu Ser Asp Ala Leu Gly Glu Ser Leu Gly Ile Asn Pro Asn 275 280 285 Ser Ala Ser Ala Ser Arg Ile Tyr Val Val Arg Thr Asn Pro Asn Asp 290 295 300 Arg Thr Thr Glu Ile Tyr His Leu Asn Leu Met Ser Leu Gly Asp Phe 305 310 315 320 Gly Leu Ala Asn Gln Phe Arg Leu Arg Ser Asn Asp Ile Val Tyr Ile 325 330 335 Asp Ala Thr Gly Leu Thr Arg Trp Gln Arg Val Val Asn Gln Ile Ile 340 345 350 Pro Phe Ser Asn Ala Leu Tyr Asn Ile Asp Arg Leu Gly Gln 355 360 365 <210> SEQ ID NO 52 <211> LENGTH: 208 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 52 Met Leu Asp Arg His Val Leu Arg Pro Val Ala Val Glu Tyr Arg Glu 1 5 10 15 Lys Thr Pro Glu Asp Val Arg Gly Ser Tyr Arg Gln Phe Arg Lys Asn 20 25 30 Leu Gly Glu Pro Trp Asn Ala Val Asn Gln Leu Ile Gln Gly Arg Pro 35 40 45 Gly Arg Ala Ala Lys Thr Leu Gly Arg Phe Thr Ile Asn Thr Leu Thr 50 55 60 Thr Leu Gly Leu Ala Asp Pro Ala Ser Arg Leu Gly Leu Pro Pro Glu 65 70 75 80 Glu Glu Ser Phe Gly Val Thr Leu Gly Tyr Tyr Gly Val Pro Ser Gly 85 90 95 Pro Phe Leu Met Leu Pro Phe Phe Gly Pro Ser Thr Leu Arg Asp Gly 100 105 110 Val Gly Leu Ala Val Asp Ala Gln Ala Arg Pro Gln Lys Tyr Ile Met 115 120 125 Asp Asp Gln Asp Gly Leu Tyr Trp Ser Thr Asn Leu Leu Gln Ala Val 130 135 140 Asp Thr Arg Ala Gln Tyr Leu Asp Leu Asp Gln Thr Ile Gln Gly Asp 145 150 155 160 Gln Tyr Ala Met Ile Arg Asp Leu Tyr Leu Gln Arg Lys Ala Phe Gln 165 170 175 Ile Ala Glu Lys Lys Gly Asp Ser Ala Asp Val Ser Phe Ile Asp Asp 180 185 190 Asp Glu Ser Glu Asp Val Pro Glu Asp Asn Thr Asp Lys Thr Glu Lys 195 200 205 <210> SEQ ID NO 53 <211> LENGTH: 326 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 53 Met Val Leu Leu Asn Ser Lys Gly Pro Val Gly Gln Gly Gln Ser Asp 1 5 10 15 Leu Met Met Thr Ala Ile Tyr Leu Met Leu Leu Val Val Ile Pro Ser 20 25 30 Ile Ile Met Ala Leu Trp Phe Gly Trp Lys Tyr Arg Ala Ser Asn Lys 35 40 45 Asp Ala Asp Tyr Lys Pro Thr Trp Ala His Ser Thr Ala Ile Glu Val 50 55 60 Val Val Trp Gly Ile Pro Val Ile Ile Ile Gly Ile Leu Ala Trp Leu 65 70 75 80 Thr Trp Trp Gly Ser His Lys Tyr Asp Pro Tyr Arg Pro Leu Glu Ser 85 90 95 Asp Lys Ala Pro Leu Thr Ile Gln Val Ile Ala Glu Gln Phe Lys Trp 100 105 110 Ile Phe Ile Tyr Pro Glu Gln Asn Ile Ala Thr Val Asn Glu Val Arg 115 120 125 Phe Pro Glu Lys Thr Pro Leu Ser Phe Lys Ile Thr Ser Asn Phe Thr 130 135 140 Met Asn Ser Phe Phe Ile Pro Gln Leu Gly Gly Gln Ile Tyr Ala Met 145 150 155 160 Ala Gly Met Gln Thr His Leu His Leu Leu Ala Asn Glu Thr Gly Val 165 170 175 Tyr Arg Gly Phe Ser Ser Asn Tyr Ser Gly Tyr Gly Phe Ser Gln Met 180 185 190 Arg Phe Lys Ala His Ser Val Thr Glu Gln Gln Phe Asn Glu Trp Val 195 200 205 Ala Ala Val Lys Ala Gly Asn Gly Thr Thr Ile Asn Pro Glu Ala Val 210 215 220 Gln Lys Thr Thr Leu Asp Gln Ala Glu Leu Ala Thr Leu Arg Asp Gly 225 230 235 240 Asp Arg Ser Lys His Gln Ile Glu His Leu Val Asn Arg Ala Lys Ala 245 250 255 Ala Gly Asp Gln Glu Ala Leu Ala Lys Ala Glu Ala Met Lys Pro Phe 260 265 270 Pro Thr Lys Pro His Pro Val Thr Tyr Tyr Ser Ser Val Glu Pro Lys 275 280 285 Leu Phe Glu Thr Ile Ile Asn His Tyr Met Ser Asn Tyr His Gly Ala 290 295 300 Asp His Ser Ala Ala His Thr Ala Ala Glu Thr His Val Ala Ala Glu 305 310 315 320 His Ala Ala Gln Gly Glu 325 <210> SEQ ID NO 54 <211> LENGTH: 207 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 54 Met Ala Arg Tyr Ile Gly Pro Lys Cys Lys Leu Ser Arg Arg Glu Gly 1 5 10 15 Thr Asp Leu Gln Leu Lys Ser Gly Val Lys Pro Phe Asp Val Lys Thr 20 25 30 Lys Lys His Ala Lys Ala Pro Gly Gln His Gly Gln Ala Arg Gly Lys 35 40 45 Gln Ser Glu Tyr Ser Leu Gln Leu Arg Glu Lys Gln Lys Val Arg Arg 50 55 60 Met Tyr Gly Val Leu Glu Arg Gln Phe Ser Asn Tyr Tyr Lys Glu Ala 65 70 75 80 Ala Arg Val Lys Gly Ala Thr Gly Glu Asn Leu Leu Lys Leu Leu Glu 85 90 95 Ser Arg Leu Asp Asn Val Val Tyr Arg Met Gly Phe Gly Ser Thr Arg 100 105 110 Ala Glu Ala Arg Gln Leu Val Ser His Arg Ser Ile Thr Leu Asn Gly 115 120 125 Arg Arg Val Asn Ile Ala Ser Ile Gln Val Lys Ala Gly Asp Val Ile 130 135 140 Ala Val His Glu Gly Ala Lys Gln Gln Leu Arg Ile Lys Asn Ala Ile 145 150 155 160 Glu Leu Ala Ala Gln Arg Gly Ile Pro Ala Trp Met Asp Val Asp His 165 170 175 Ser Lys Leu Glu Gly Thr Phe Lys Ala Ala Pro Asp Arg Ser Asp Leu 180 185 190 Pro Ala Glu Ile Asn Glu Ser Leu Ile Val Glu Leu Tyr Ser Lys 195 200 205 <210> SEQ ID NO 55 <211> LENGTH: 355 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 55 Met Ala His Ala Glu Val Asn Ser Ser Ser Thr Gln Gln Val Asn Gly 1 5 10 15 Leu Ser Ser Gly Ala Gln Ala Glu Glu Asn Lys Asp Glu Asn Leu Leu 20 25 30 Asp Gln Ile Pro Arg Trp Ile Asp Ala Thr Pro Thr Ile Phe Pro Glu 35 40 45 Gln Ser Asn Glu Pro Ile Val Pro Pro Thr Glu Gln Thr Glu Asp Gln 50 55 60 Thr Trp Phe Asp Arg Lys Gln Lys Lys Ile Arg Asn Trp Ala Asp Arg 65 70 75 80 Thr Ser Gly Lys Ile Asp Asn Trp Phe Gly Glu Val Asp Pro Gln Lys 85 90 95 Pro Ala Ser Ala Thr Ile Arg Val Met Ile Asp Asn Tyr Trp Asn Glu 100 105 110 Tyr Asp Asn Tyr Glu Ile Lys Pro Arg Ile Arg Gly Lys Ile Lys Leu 115 120 125 Pro Thr Leu Glu Lys Arg Leu Ser Val Val Phe Gly Asp Asp Ser Leu 130 135 140 Asp Asp Glu Phe Asn Asn Ser Pro Ala Asn Ile Asn Gln Asn Pro Asn 145 150 155 160 Gln Asp Pro Asn Lys Lys Leu Asp Gly Lys Arg Thr Arg Asp Asp Asn 165 170 175 Ser Ser Ile Ala Leu Arg Trp Ser Asn Phe Ser Lys Lys Leu Pro Phe 180 185 190 Glu Thr Asp Ala Asp Leu Gly Ile Arg Ser Gly Asp Asp Ile Tyr Val 195 200 205 Arg Leu Lys Ala Ser Arg Asp Trp Gln Leu Arg Asn Asp Phe Lys Phe 210 215 220 Tyr Ala Glu Gln Ile Tyr Arg Tyr Gly Ile Asp Ser Glu Asn Tyr Leu 225 230 235 240 Arg Thr Asn Leu Glu Leu Thr His Ala Arg Pro Asn Gln Pro Ile Leu 245 250 255 Ser Asn Gln Phe Ser Leu Thr Tyr Ala Asp Asp Gln Asp Asp Asp Leu 260 265 270 Thr Trp Glu Asn Arg Leu Phe Arg Glu His Ser Phe Phe Ala Asn Asn 275 280 285 Arg Phe Asn Tyr Gly Ile Tyr Thr Gly Gly Tyr Tyr Asn Asp Asn Asp 290 295 300 Leu Arg Leu Asn Ser Trp Gly Pro Phe Val Ser Trp Arg Gln Pro Val 305 310 315 320 Leu Arg Glu Trp Phe Phe Val Gln Gly Asp Leu Asn Tyr Phe Asn Asp 325 330 335 His Arg Glu Asp Arg Asn His Tyr Val Ser Thr Phe Leu Arg Leu Glu 340 345 350 Ala Leu Phe 355 <210> SEQ ID NO 56 <211> LENGTH: 108 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 56 Met Ser Thr Leu Leu Val Ala Cys Asn Lys His Glu Asn Lys Thr Glu 1 5 10 15 Thr Thr Ser Asp Ala Ser Thr Pro Val Gln Thr Ala Gln Ser Asn Asn 20 25 30 Asn Glu Ala Val Asp Thr Ala His Thr Ala Glu Asn Ser Leu Asp Trp 35 40 45 Asp Gly Lys Tyr Lys Gly Thr Leu Pro Cys Ala Asp Cys Glu Gly Ile 50 55 60 Lys Thr Glu Leu Glu Leu Lys Asp Asp Lys Thr Tyr Glu Leu Thr Glu 65 70 75 80 Thr Tyr Leu Gly Lys Gly Asp Ala Asn Pro Phe Glu Pro Met Val Ser 85 90 95 Leu Leu Ser Ile Lys Thr Ile Leu Leu Leu Leu Pro 100 105 <210> SEQ ID NO 57 <211> LENGTH: 635 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 57 Met Arg Gly Phe Gly Ala Arg Ser Thr Phe Gly Val Arg Gly Ile Arg 1 5 10 15 Leu Tyr Val Asp Gly Ile Pro Ala Thr Met Pro Asp Gly Gln Gly Gln 20 25 30 Thr Ser Asn Ile Asp Leu Ser Ser Leu Asp His Val Glu Val Leu Thr 35 40 45 Gly Pro Phe Ser Ser Leu Tyr Gly Asn Ser Ser Gly Gly Thr Ile Leu 50 55 60 Thr Ser Thr Lys Glu Gly Gln Gly Lys Asp Ser Ile Glu Leu Ser Tyr 65 70 75 80 Ser Gly Gly Ser His Asp Lys Ser Arg Ala Gly Leu Val Leu Gln Gly 85 90 95 Gly Ala Lys Gly Ala Asn Glu Pro Ser Tyr Ile Ile Ser Ser Ser Tyr 100 105 110 Phe Asp Thr Asp Gly Tyr Arg Glu His Ser Gly Ala Glu Lys Val Leu 115 120 125 Asn Asn Ala Lys Leu Ser Trp Asn Leu Asp Asp Gly Ser Lys Ile Asn 130 135 140 Trp Val Thr Asn Tyr Val Lys Ile His Ala Asp Asp Pro Met Gly Leu 145 150 155 160 Glu Arg Lys Asp Trp Gln Ala Asn Pro Lys Gln Ile Ala Pro Tyr Val 165 170 175 Lys Lys Trp Gly Phe Asn Ala Arg Lys Asp Ile Glu Gln Thr Gln Thr 180 185 190 Gly Ile Thr Trp Phe Lys Pro Ile Asn Asp Gln His Glu Leu Tyr Ala 195 200 205 Met Ala Tyr Leu Gly Asn Arg Gln Val Thr Gln Tyr Gln Ser Ile Pro 210 215 220 Gln Gly Gln Val Val Val Glu Asn Gly Lys Pro Val Tyr Thr Gly Gln 225 230 235 240 Lys Ser Pro Lys His Ala Gly Gly Val Ile Asp Phe Glu Arg Asn Tyr 245 250 255 Tyr Gly Ala Asp Phe Arg Trp Thr Gly Lys Glu Leu Leu Pro Asn Thr 260 265 270 Thr Val Ser Ile Gly Val Ala Phe Asp Ala Met Asp Glu Glu Arg Lys 275 280 285 Gly Phe Glu Asn Phe Asn Ala Asp Gly Ile Tyr Gly Val Lys Gly Asn 290 295 300 Leu Arg Arg Asp Glu Asp Asn Thr Leu Trp Asn Ile Asp Pro Tyr Leu 305 310 315 320 Gln Ala Ser Trp Gln Phe Leu Pro Thr Trp Arg Leu Asp Thr Gly Val 325 330 335 Arg Tyr Ser Asn Val His Tyr Lys Ser Lys Asp His Phe Thr Ser Gly 340 345 350 Pro Asp Glu Tyr Gly Thr Val Asn Gly Asp Asp Ser Gly Lys Thr Asp 355 360 365 Tyr Glu Lys Val Leu Pro Ser Ala Ala Leu Ser Trp Gln Ile Leu Pro 370 375 380 Glu Leu Met Ala Tyr Val Ser Tyr Ala Lys Gly Phe Glu Thr Pro Thr 385 390 395 400 Phe Thr Glu Met Ala Tyr His Thr Asp Ile Ser Lys Ser Gly Phe Asn 405 410 415 Phe Gly Leu Lys Pro Ser Thr Ser Asp Thr Tyr Glu Thr Gly Leu Lys 420 425 430 Ser Gln Asn Leu Leu Gly Asp Phe Thr Leu Ala Val Phe Gln Thr Lys 435 440 445 Thr Lys Asn Asp Ile Val Ser Ala Gly Asn Leu Gly Gly Arg Ser Thr 450 455 460 Phe Arg Asn Ala Asp Lys Thr Leu Arg Glu Gly Val Glu Phe Ala Trp 465 470 475 480 Asn Lys Lys Leu Trp Arg Asp Leu Thr Ala Thr Ala Ser Tyr Thr Tyr 485 490 495 Leu Asp Ala Thr Phe Asp Ala Asn Val Pro Glu Lys Leu Asp Gln Asp 500 505 510 Asn Lys Val Leu Ala Ser Ala Ile Pro Thr Gly Asn Ala Ile Pro Gly 515 520 525 Ile Ala Lys Asn Gln Ala Tyr Ala Ser Leu Ala Trp Gln Pro Ser His 530 535 540 Gly Leu Tyr Gly Gly Val Asp Val Gln Tyr Met Asp Lys Val Tyr Val 545 550 555 560 Asn Asp Thr Asn Ser Asp Ala Ala Pro Ser Tyr Ser Val Thr Ser Ala 565 570 575 Asn Val Gly Tyr Ala Trp Val Met Gly Asp Trp Lys Val Asn Ser Phe 580 585 590 Ala Arg Val Asp Asn Leu Phe Asp Lys Lys Tyr Ala Gly Ser Val Ile 595 600 605 Val Asn Asp Gly Asn Ser Arg Tyr Phe Glu Pro Ala Asp Gly Arg Asn 610 615 620 Trp Ser Ala Gly Leu Arg Val Ile Lys Gln Phe 625 630 635 <210> SEQ ID NO 58 <211> LENGTH: 381 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 58 Met Thr Gly Ile Ser Ser Val Tyr Ala Gln Glu Gln Val Asp Pro Ala 1 5 10 15 Tyr Lys Pro Gly Asn Pro Ile Tyr Asp Lys Trp Asp Arg Phe Tyr Lys 20 25 30 Ile Glu Gln Ser Gln Pro Gln Glu Ala Glu Lys Ile Leu Val Glu Leu 35 40 45 Ser Lys Leu Thr Pro Thr Asp Ile Lys Val Trp Lys Ser Leu Thr Tyr 50 55 60 Leu Gln Ile Arg Leu Glu Lys Arg Glu Glu Ala Leu Gln Ser Leu Arg 65 70 75 80 Gln Ala Arg Asn Leu Ala Pro Gln Asp Asp Thr Leu Lys Leu Gln Glu 85 90 95 Ala Tyr Leu Leu Asn Gln Gln Lys Lys Asp Arg Glu Ala Leu Val Leu 100 105 110 Phe Lys Glu Leu Ser Ser Ser Ser Asp Pro Glu Ile Ala Ala Lys Ala 115 120 125 Thr Gln Ala Val Lys Asn Leu Ser Gly Gly Glu Val Lys Pro Tyr Phe 130 135 140 Lys Asp Ile Tyr Phe Ala Pro Ser Tyr Glu Ser Arg Tyr Asp Asp Val 145 150 155 160 Ile Phe Pro Leu Lys Met Arg Tyr Gly Lys Asn Ile Asp Asn Gly Arg 165 170 175 Ala Gln Val Tyr Ala Phe Leu Asn Leu Asn Arg Asp Thr Gln Ser Gln 180 185 190 Gly Gly Val Arg Pro Glu Ile Ile Asp Glu Asn Ala Ala Thr Leu Gly 195 200 205 Leu Gly Ala Asn Tyr Gln Pro Trp Thr Ser Ile Pro Val Arg Ala Tyr 210 215 220 Val Glu Val Gly Gly Ser Tyr Asp Leu Ile Asp Arg Asn Arg Lys Arg 225 230 235 240 Phe Arg Glu Ser Val Val Gly Gly Val Thr Gly Tyr Gln Glu Trp Tyr 245 250 255 Ser Gln Ser Asn Cys Asp His Ser Leu Cys Leu Asp Asn Tyr Phe Thr 260 265 270 Asp Leu Tyr Gly Asn Val Ala Thr Tyr Ser Arg Glu Asp Tyr Asn Val 275 280 285 Ile Gly Asp Leu Arg Leu Arg Thr Gly Leu Asn Leu Tyr Lys Gly Glu 290 295 300 Ser Gly Thr Val Gln Ala Tyr Val Lys Leu His Gly Leu Ala Asp Ser 305 310 315 320 Glu Asp Glu Tyr Tyr Asn Asn Leu Phe Glu Tyr Gly Pro Gly Ile Ser 325 330 335 Trp Gln Pro Phe Asn Tyr Gln Pro Ile Lys Leu Arg Val Glu Arg Leu 340 345 350 Tyr Gly Asn Tyr Phe Lys Asp Val Pro Val Asn Thr Lys Asp His Tyr 355 360 365 Asn Asn Thr Arg Val Glu Leu Val Phe Tyr Lys Asp Phe 370 375 380 <210> SEQ ID NO 59 <211> LENGTH: 212 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 59 Met Ala Ile Gly Leu Val Gly Arg Lys Cys Gly Met Thr Arg Ile Phe 1 5 10 15 Thr Asp Ala Gly Val Ser Val Pro Val Thr Val Ile Glu Val Asp Pro 20 25 30 Asn Arg Ile Thr Gln Ile Lys Thr Leu Glu Thr Asp Gly Tyr Gln Ala 35 40 45 Val Gln Val Thr Thr Gly Glu Arg Arg Glu Ser Arg Val Thr Asn Ala 50 55 60 Gln Lys Gly His Phe Ala Lys Ala Gly Val Ala Ala Gly Arg Leu Val 65 70 75 80 Lys Glu Phe Arg Val Thr Glu Ala Glu Leu Glu Gly Arg Glu Ile Gly 85 90 95 Gly Thr Ile Gly Val Asp Leu Phe Thr Val Gly Gln Val Val Asp Val 100 105 110 Thr Gly Gln Ser Lys Gly Lys Gly Phe Gln Gly Gly Val Lys Arg Trp 115 120 125 Asn Phe Arg Thr Gln Asp Ala Thr His Gly Asn Ser Val Ser His Arg 130 135 140 Val Leu Gly Ser Thr Gly Gln Asn Gln Thr Pro Gly Arg Val Phe Lys 145 150 155 160 Gly Lys Lys Met Ala Gly His Leu Gly Asp Glu Arg Val Thr Val Gln 165 170 175 Gly Leu Glu Ile Val Ser Ile Asp Ala Glu Arg Ser Val Leu Val Val 180 185 190 Lys Gly Ala Ile Pro Gly Ala Thr Gly Gly Asp Val Ile Val Arg Pro 195 200 205 Thr Ile Lys Ala 210 <210> SEQ ID NO 60 <211> LENGTH: 424 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 60 Met Leu Lys Ala Gln Lys Leu Thr Leu Ala Val Leu Ile Ser Ala Ala 1 5 10 15 Ile Ile Ser Ser Ala Gln Ala Ser Glu Gln Ser Glu Ala Lys Gly Phe 20 25 30 Val Glu Asp Ala Asn Gly Ser Ile Leu Phe Arg Thr Gly Tyr Ile Ser 35 40 45 Arg Asp Lys Lys Asp Gly Arg Ala Asp Asn Ser Ser Phe Ala Gln Thr 50 55 60 Ala Ile Val Asn Ile Asp Ser Gly Phe Thr Pro Gly Ile Val Gly Phe 65 70 75 80 Gly Val Gly Val Val Gly Asp Gly Ser Phe Lys Ile Gly Glu Asn Lys 85 90 95 Asn Ala Gly Asn Asn Met Ile Pro Gln His Asn Asp Gly Ser Ala Tyr 100 105 110 Asp His Trp Ala Arg Gly Gly Ala Asn Val Lys Ala Arg Phe Ser Asn 115 120 125 Thr Thr Val Arg Tyr Gly Thr Gln Val Leu Asp Leu Pro Val Leu Ala 130 135 140 Ser Asn Thr Ala Arg Leu Val Pro Glu Tyr Phe Thr Gly Thr Leu Leu 145 150 155 160 Thr Ser His Glu Ile Lys Asp Leu Glu Val Val Ala Gly Lys Phe Thr 165 170 175 Lys Asn Gln Tyr Ser Asp Gln Ile Ala Thr Asp Gln Asn Gly Leu Asp 180 185 190 Arg Ala Val Val Trp Gly Ala Lys Tyr Lys Phe Asp Asp Gln Ile Ser 195 200 205 Gly Ser Tyr Tyr Gly Val Asp Val Lys Asp Lys Leu Asp Arg His Tyr 210 215 220 Val Asn Val Asn Tyr Lys Gln Pro Leu Ala Asn Asp Ser Ser Leu Thr 225 230 235 240 Tyr Asp Phe Ser Gly Tyr His Thr Lys Phe Asp Lys Gly Ala Asn Leu 245 250 255 Ser Tyr Ala Thr Gly Pro Ala Asp Glu Asp Lys Thr Asn Asn Ile Trp 260 265 270 Ala Ile Ser Gly Thr Tyr Ala Thr Gly Pro His Ser Val Met Leu Ala 275 280 285 Tyr Gln Gln Asn Ser Gly Asn Ile Gly Tyr Asn Tyr Gly Val Asn Gln 290 295 300 Asp Gly Gly Gln Ser Val Tyr Leu Pro Asn Ser Tyr Leu Ser Asp Phe 305 310 315 320 Ile Gly Asn Asp Glu Lys Ser Ala Gln Ile Gln Tyr Ser Leu Asp Phe 325 330 335 Gly Lys Leu Gly Val Leu Pro Gly Leu Asn Trp Thr Thr Ala Tyr Val 340 345 350 Tyr Gly Trp Asp Ile Lys Thr Ser Asn Gly Ala Asp Asp Ser Asn Glu 355 360 365 Ser Glu Phe Phe Asn Gln Val Lys Tyr Thr Val Gln Ser Gly Phe Ala 370 375 380 Lys Gly Ser Ser Leu Arg Leu Arg Asn Ser Ile Tyr Arg Ala Asp Asn 385 390 395 400 Ala Tyr Thr Thr Asp Tyr Met Pro Asp Thr Asn Glu Trp Arg Ile Phe 405 410 415 Leu Asp Ile Pro Val Thr Leu Phe 420 <210> SEQ ID NO 61 <211> LENGTH: 641 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 61 Met Gln Leu Lys Asp Val Pro Gln Ile Val Asn Val Val Pro Lys Gln 1 5 10 15 Val Leu Arg Glu Gln Thr Val Thr Ser Met Gln Gly Ala Leu Gln Asn 20 25 30 Val Ala Gly Leu Ser Phe Ser Val Gly Asp Gly Gln Arg Asp Gln Val 35 40 45 Met Ile Arg Gly Phe Ser Ala Ile Thr Asp Asn Tyr Val Asp Gly Ile 50 55 60 Arg Asp Asp Ala Leu Tyr Phe Arg Asp Met Ser Asn Val Glu Arg Ile 65 70 75 80 Glu Val Leu Lys Gly Pro Ala Ser Val Leu Tyr Gly Arg Gly Ser Ala 85 90 95 Gly Gly Leu Val Asn Lys Ile Asn Lys Lys Pro Met Asp Gln Ser Leu 100 105 110 Arg Glu Val Ser Leu Ile Gly Ser Thr Thr Gly Gln Arg Arg Ala Glu 115 120 125 Val Asp Val Asn Glu Lys Val Ala Glu Asn Val Lys Val Arg Leu Thr 130 135 140 Gly Ala Val Glu Asp Ser Asp Gly Tyr Arg Asp Gln Ala Phe Leu Lys 145 150 155 160 Arg Gln Ala Val Ala Pro Ser Val Gln Trp Asp Ile Thr Asp Lys Thr 165 170 175 Lys Leu Leu Leu Gln Ala Asp Tyr Leu His Asp Asn Arg Leu Ala Asp 180 185 190 Gln Gly Phe Pro Thr Asp Pro Ile Thr Gly Lys Pro Val Lys Thr Asn 195 200 205 Pro Lys Thr Phe Tyr Gly Ala Leu Asn Gly Lys Glu Val Gly Asp Val 210 215 220 Asp Thr Glu Ile Ser Ser Gln Thr Ile Ser Leu Asp His Glu Phe Asn 225 230 235 240 Asp Asn Phe Lys Tyr His Gly Ala Val Arg His Tyr Asn Tyr Ser Leu 245 250 255 Asp Arg Gln Tyr Ser Val Asp Ser His Gln Lys Leu Pro Ala Asp Gln 260 265 270 Ile Gln Leu Thr Gln Asn Lys Arg Leu Arg Asn Glu Asp Gly Val Tyr 275 280 285 Val Gln Gln Glu Leu Ser Ala Val Phe Asn Thr Gly Phe Leu Lys His 290 295 300 Ser Thr Leu Ile Gly Ala Glu Tyr Ser Lys Gln His Lys Asp Glu Leu 305 310 315 320 Val Trp Ser Lys Ala Arg Gln Ile Thr Asn Ile Phe Asn Pro Gln Leu 325 330 335 Glu Asn Trp Ala Pro Leu Asp Thr Asn Val Asp Ala Asp Thr Asn Asn 340 345 350 Thr Asn Thr Phe Glu Asn Tyr Gly Val Tyr Leu Gln Asp Leu Met Thr 355 360 365 Val Thr Asp Gln Leu Lys Val Leu Val Gly Leu Arg Tyr Asp Asn Leu 370 375 380 Ser Gln Asp Arg Asp Asp Lys Thr Ser Lys Asn Val Asp Leu Asn Arg 385 390 395 400 Thr Asp Asn Thr Tyr Ser Pro Arg Ile Gly Val Val Tyr Gln Pro Val 405 410 415 Asn Asn Leu Ser Leu Tyr Thr Ser Tyr Asn Arg Ser Phe Gln Pro Leu 420 425 430 Ala Asp Ser Phe Val Phe Tyr Lys Asn Ser Asp Asp Leu Arg Pro Thr 435 440 445 Lys Thr Glu Asn Tyr Glu Ile Gly Ala Lys Trp Asp Val Asn Asp Gln 450 455 460 Leu Asn Val Thr Leu Ala Leu Phe Glu Met Ser Gln Thr Asn Ile Gln 465 470 475 480 Asn Lys Asp Pro Asn Asp Pro Lys Gly Leu Thr Ala Ile Leu Ala Gly 485 490 495 Glu Gln Lys Thr Lys Gly Val Glu Ile Ser Leu Ala Gly Gln Leu Thr 500 505 510 Asp Gln Leu Ser Val Leu Ala Gly Tyr Ser Tyr Met Asp Gly Lys Ile 515 520 525 Glu Lys Ser Ala Ile Gly Phe Thr Gly Asn His Ser Ala Leu Thr Pro 530 535 540 Asn Asn Thr Ala Asn Leu Trp Leu Lys Tyr Gln Ile Asn Asp His Trp 545 550 555 560 Tyr Ala Ala Val Gly Gly Arg Gly Glu Ser Ser Arg Phe Ser Ala Pro 565 570 575 Asp Asn Lys Asn Val Leu Pro Gly Tyr Ala Val Val Asn Ala Ala Leu 580 585 590 Gly Tyr Gln Ser Glu Arg Tyr Asp Val Asn Leu Asn Leu Asn Asn Leu 595 600 605 Phe Asp Arg Asp Tyr Phe Val Ser Gly His Ser Gly Ala Asn Asp Ser 610 615 620 Asn Met Met Gly Asp Pro Leu Asn Ala Gln Val Ala Leu Arg Tyr Arg 625 630 635 640 Phe <210> SEQ ID NO 62 <211> LENGTH: 209 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 62 Met Glu Glu Ala Val Gln Val Leu Asn Ser Leu Pro Ala Ala Lys Phe 1 5 10 15 Lys Glu Ser Leu Asp Ile Ser Val Asn Leu Gly Val Asp Pro Arg Lys 20 25 30 Ser Asp Gln Val Val Arg Gly Ala Thr Thr Leu Pro Ala Gly Thr Gly 35 40 45 Lys Thr Val Arg Val Ala Val Phe Ala Gln Gly Ala Gln Ala Glu Ala 50 55 60 Ala Lys Glu Ala Gly Ala Asp Val Val Gly Phe Asp Asp Leu Ala Glu 65 70 75 80 Ser Ile Gln Gly Gly Asn Leu Asp Phe Asp Val Val Ile Ala Ala Pro 85 90 95 Asp Ala Met Arg Val Val Gly Lys Leu Gly Thr Ile Leu Gly Pro Arg 100 105 110 Gly Leu Met Pro Asn Pro Lys Val Gly Thr Val Thr Pro Asp Val Ala 115 120 125 Gly Ala Val Lys Asn Ala Lys Ser Gly Gln Ala Arg Tyr Arg Val Asp 130 135 140 Lys Ala Gly Ile Ile His Ala Ala Ile Gly Gln Val Gly Phe Asp Ala 145 150 155 160 Ala Ala Ile Arg Gln Asn Val Glu Thr Leu Val Ala Asp Leu Lys Lys 165 170 175 Leu Lys Pro Ala Thr Ser Lys Gly Val Tyr Ile Lys Lys Ile Thr Leu 180 185 190 Ser Ser Thr Met Gly Pro Gly Leu Thr Val Asp Val Asn Asn Val Ser 195 200 205 Asn <210> SEQ ID NO 63 <211> LENGTH: 147 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 63 Met Tyr Pro Ala Pro Thr Val Asp Gln Leu Ala Ile Asp His Ala Pro 1 5 10 15 Lys Phe Glu Asn Lys Arg Gly Asn Arg Phe Ala Leu Pro Arg Pro Glu 20 25 30 Pro Leu Gln Thr Asp Thr Thr Ala Asp Ala Ser Ala Gln Thr Gly Ser 35 40 45 Ala Leu Gly Arg Pro Gln Leu Val Thr Asp Gly Asn Lys Asn Pro Leu 50 55 60 Leu Lys Ile Asp Gly Ser Thr Ala Glu Ile Trp Gln Tyr Thr Lys Ala 65 70 75 80 Thr Leu Ser Thr Leu Asn Tyr Asn Val Ile Ala Gln Gly Asn Asn Gln 85 90 95 Ala Thr Ile Lys Val Asn Asp Asn Thr Tyr Val Leu Lys Leu Thr Gly 100 105 110 Val Gly Ser Ser His Ser Leu Ala Leu Phe Asn Pro Asp Asn Thr Phe 115 120 125 Ala Ser Pro Asp Val Ala Ala Glu Val Leu Asn Gln Ile Tyr Gln Asn 130 135 140 Trp Pro Ala 145 <210> SEQ ID NO 64 <211> LENGTH: 201 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 64 Met Lys Val Ser Gly Leu Val Gly Thr Asn Leu Ser Asp Gly Tyr Thr 1 5 10 15 Met Lys Ala Gln Phe Asp Asn Val Asn Gly Leu Lys Pro Arg Ala Lys 20 25 30 Val Thr Met Ser Gly Val Thr Ile Gly Arg Val Asp Ser Ile Thr Leu 35 40 45 Asp Pro Val Thr Arg Leu Ala Thr Val Thr Phe Asp Leu Asp Gly Lys 50 55 60 Leu Thr Ser Phe Asn Ala Glu Gln Leu Lys Glu Val Gln Lys Asn Ala 65 70 75 80 Leu Asp Glu Leu Arg Tyr Ser Ser Asp Tyr Thr Gln Ala Thr Pro Ala 85 90 95 Gln Gln Lys Thr Met Glu Gln Gln Leu Ile Ser Asn Met Asn Ser Ile 100 105 110 Thr Ser Ile Asp Glu Asp Ala Tyr Ile Met Val Ala Thr Asn Gly Leu 115 120 125 Leu Gly Glu Lys Tyr Leu Lys Ile Val Pro Gly Gly Gly Leu Asn Tyr 130 135 140 Leu Lys Arg Gly Asp Thr Ile Ser Asn Thr Gln Gly Thr Met Asp Leu 145 150 155 160 Glu Asp Leu Ile Ser Lys Phe Ile Thr Gly Gly Gly Ala Gly Lys Val 165 170 175 Ala Ala Gly Ser Ser Ser Ala Glu Glu Lys Ala Pro Ala Ser Thr Asp 180 185 190 Ser Ser Ala Gln Pro Ser Phe Val Glu 195 200 <210> SEQ ID NO 65 <211> LENGTH: 183 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 65 Met Gly Val Ser Ser Phe Thr Phe Ala Gly Asn Trp Gln Val Lys Phe 1 5 10 15 Gly Gly Ser Val Ile Ala Pro Ser Glu Asp Thr Thr Thr Ala Leu Gly 20 25 30 Val Val Lys Ala Asp His Glu Tyr Ala Phe Thr Pro Ser Val Glu Tyr 35 40 45 Phe Phe Gly Gln Ser Pro Phe Ser Ala Glu Leu Leu Leu Ala Thr Pro 50 55 60 Val Asn His Asp Val Leu Leu Asp Gly Gln Lys Val Ala Arg Ile Lys 65 70 75 80 Gln Leu Pro Pro Thr Ile Thr Ala Lys Tyr His Phe Lys Asn Ser Thr 85 90 95 Arg Phe Thr Pro Tyr Ile Gly Ile Gly Ala Thr Ala Phe Ile Pro Trp 100 105 110 Asp Glu Gln Gly Val Ala Asp Lys Val Lys Glu Asp Phe Gly Val Ala 115 120 125 Gly Gln Ile Gly Phe Asn Phe Gln Pro Ala Asp Ala Lys Asn Trp Gly 130 135 140 Val Phe Val Asp Val Arg Tyr Ala Asp Ile Ser Pro Glu Val Thr Leu 145 150 155 160 Thr Asn Gly Ala Lys Phe Asp Leu Asp Ile Asn Pro Phe Val Tyr Thr 165 170 175 Leu Gly Tyr Ser Tyr Lys Phe 180 <210> SEQ ID NO 66 <211> LENGTH: 231 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 66 Met Met Lys Ile Leu Lys Leu Ser Phe Leu Ala Leu Gly Met Gly Leu 1 5 10 15 Ser Gly Phe Ala Gln Ala Asp Phe Ile Gly Val Lys Gly Asp Val Gly 20 25 30 Tyr Trp Phe Tyr Asp Gly Lys Ala Asn Met Ser Ser Gln Ser Pro Glu 35 40 45 Asp Gln Asp Leu Asp Arg Lys Gly Ser Ala Gln Leu Ser Leu Ala Phe 50 55 60 Glu His Pro Ile Pro Phe Ile Pro Asn Ala Lys Ile Arg Tyr Val Asn 65 70 75 80 Leu Asp Thr Gln Thr Lys Ser Glu Thr Leu Gly Gln Ala Asn Tyr Asn 85 90 95 Val Asp Leu Asp His Ser Asp Phe Ile Leu Tyr Tyr Glu Leu Leu Asp 100 105 110 Asn Ile Val Ser Val Asp Ala Gly Leu Gly Ala Thr Val Leu Asn Gly 115 120 125 Asp Ile Thr Ala Tyr Thr Gly Lys Arg Val Asp Ile Asp Lys Thr Tyr 130 135 140 Pro Ile Ala Tyr Leu Ser Gly Glu Val Lys Leu Pro Phe Thr Gly Leu 145 150 155 160 Ser Ala Lys Gly Glu Ala Thr Tyr Thr Asn Phe Asp Asp Ala Lys Ile 165 170 175 Thr Asp Ala Leu Val Glu Ala Lys Tyr Lys Phe Ala Asp Asn Leu Leu 180 185 190 Ile Asp Leu Gly Leu Thr Ala Gly Tyr Arg Ile Leu Asn Ile Asp Leu 195 200 205 Asp Asp Tyr Asp Asn Asn Asp Leu Lys Phe Glu Phe Lys Gly Pro Tyr 210 215 220 Val Gly Leu Glu Ala His Phe 225 230 <210> SEQ ID NO 67 <211> LENGTH: 142 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 67 Met Asp Asp Leu Lys Glu Asn Val Lys Glu Lys Gln Thr Ala Gly Lys 1 5 10 15 Glu Ala Val Ala Asp Lys Val Asp Glu Leu Lys Thr Lys Ala Ala Asp 20 25 30 Ala Lys Val Gln Gly Glu Lys Ala Leu Glu Asp Leu Lys Glu Asn Val 35 40 45 Lys Glu Lys Gln Ala Ala Ala Lys Glu Ala Val Glu Asp Lys Ala Ser 50 55 60 Asp Leu Lys Gly Lys Leu Asp Asp Ala Gln His Ser Leu Gln Asp Lys 65 70 75 80 Phe Asp His Leu Arg Thr Glu Ala Ala His Lys Leu Asp Asp Ala Lys 85 90 95 Ala Lys Ala Ala Glu Leu Lys Glu Glu Ala Ala Thr Lys Phe Asp Glu 100 105 110 Leu Lys Thr Gln Ala Thr Ala Lys Phe Asp Glu Leu Lys Lys Thr Ala 115 120 125 Thr Glu Lys Leu Asn Lys Leu Lys Asn His Asp Ser Ala Glu 130 135 140 <210> SEQ ID NO 68 <211> LENGTH: 344 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 68 Met Lys Ala Gln Val His Ala Gly Gly Arg Gly Lys Ala Gly Gly Val 1 5 10 15 Lys Val Ala Lys Ser Lys Glu Asp Val Ile Glu Phe Ala Asn Asn Ile 20 25 30 Ile Gly Thr Arg Leu Val Thr Tyr Gln Thr Asp Ala Asn Gly Gln Pro 35 40 45 Val Asn Ser Ile Ile Val Ala Glu Asp Val Tyr Pro Val Glu Arg Glu 50 55 60 Leu Tyr Leu Gly Ala Val Val Asp Arg Ser Ser Arg Arg Ile Thr Phe 65 70 75 80 Met Ala Ser Thr Glu Gly Gly Val Glu Ile Glu Lys Val Ala Glu Glu 85 90 95 Thr Pro Glu Lys Ile Ile Lys Val Glu Val Asp Pro Leu Val Gly Leu 100 105 110 Gln Pro Phe Gln Ala Arg Glu Val Ala Phe Ala Leu Gly Leu Lys Asp 115 120 125 Lys Gln Ile Gly Gln Phe Val Lys Ile Met Thr Ala Ala Tyr Gln Ala 130 135 140 Phe Val Glu Asn Asp Phe Ala Leu Phe Glu Ile Asn Pro Leu Ser Val 145 150 155 160 Arg Glu Asn Gly Glu Ile Leu Cys Val Asp Ala Lys Val Gly Ile Asp 165 170 175 Ser Asn Ala Leu Tyr Arg Leu Pro Lys Val Ala Ala Leu Arg Asp Lys 180 185 190 Ser Gln Glu Asn Glu Arg Glu Leu Lys Ala Ser Glu Phe Asp Leu Asn 195 200 205 Tyr Val Ala Leu Glu Gly Asn Ile Gly Cys Met Val Asn Gly Ala Gly 210 215 220 Leu Ala Met Ala Thr Met Asp Ile Ile Lys Leu Tyr Gly Gly Gln Pro 225 230 235 240 Ala Asn Phe Leu Asp Val Gly Gly Gly Ala Thr Lys Glu Arg Val Ile 245 250 255 Glu Ala Phe Lys Ile Ile Leu Ala Asp Thr Ser Val Gln Gly Val Leu 260 265 270 Ile Asn Ile Phe Gly Gly Ile Val Arg Cys Asp Met Ile Ala Glu Ala 275 280 285 Ile Ile Ala Ala Val Gln Glu Val Asn Val Thr Val Pro Val Val Val 290 295 300 Arg Leu Glu Gly Asn Asn Ala Glu Leu Gly Ala Lys Leu Leu Asp Glu 305 310 315 320 Ser Gly Leu Lys Leu Ile Ser Ala Asn Gly Leu Ser Asp Ala Ala Glu 325 330 335 Lys Val Val Ala Ala Val Lys Ala 340 <210> SEQ ID NO 69 <211> LENGTH: 415 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 69 Met Met Ser Ala Lys Leu Trp Ala Pro Ala Leu Thr Ala Cys Ala Leu 1 5 10 15 Ala Thr Ser Ile Ala Leu Val Gly Cys Ser Lys Gly Ser Asp Glu Lys 20 25 30 Gln Gln Ala Ala Ala Ala Gln Lys Met Pro Pro Ala Glu Val Gly Val 35 40 45 Ile Val Ala Gln Pro His Ser Val Glu Gln Ser Val Glu Leu Ser Gly 50 55 60 Arg Thr Ser Ala Tyr Gln Ile Ser Glu Val Arg Pro Gln Thr Ser Gly 65 70 75 80 Val Ile Leu Lys Arg Leu Phe Ala Glu Gly Ser Tyr Val Arg Glu Gly 85 90 95 Gln Ala Leu Tyr Glu Leu Asp Ser Arg Thr Asn Arg Ala Thr Leu Glu 100 105 110 Asn Ala Lys Ala Thr Leu Leu Gln Gln Gln Ala Asn Leu Ala Ser Leu 115 120 125 Arg Thr Lys Leu Asn Arg Tyr Lys Gln Leu Val Ser Ser Asn Ala Val 130 135 140 Ser Lys Gln Glu Tyr Asp Asp Leu Leu Gly Gln Val Asn Val Ala Glu 145 150 155 160 Ala Gln Val Ser Ala Ala Lys Ala Gln Val Thr Asn Ala Asn Val Asp 165 170 175 Leu Gly Tyr Ser Thr Ile Arg Ser Pro Ile Ser Gly Gln Ser Gly Arg 180 185 190 Ser Ser Val Thr Ala Gly Ala Leu Val Thr Ala Asn Gln Thr Asp Pro 195 200 205 Leu Val Thr Ile Gln Gln Leu Asp Pro Ile Tyr Val Asp Ile Asn Gln 210 215 220 Ser Ser Ala Glu Leu Leu Arg Leu Arg Gln Gln Leu Ser Lys Gly Ser 225 230 235 240 Leu Asn Asn Ser Asn Asn Thr Lys Val Lys Leu Lys Leu Glu Asp Gly 245 250 255 Ser Thr Tyr Pro Ile Glu Gly Gln Leu Ala Phe Ser Asp Ala Ser Ala 260 265 270 Asn Gln Asp Thr Gly Thr Ile Thr Leu Arg Ala Val Phe Ser Asn Pro 275 280 285 Asn His Leu Leu Leu Pro Gly Met Tyr Thr Thr Ala Gln Ile Val Gln 290 295 300 Gly Val Val Pro Asn Ala Tyr Leu Ile Pro Gln Ala Ala Ile Thr Arg 305 310 315 320 Leu Pro Thr Gly Gln Ala Val Ala Met Leu Val Asn Ala Lys Gly Ala 325 330 335 Val Glu Ser Arg Pro Val Glu Thr Ser Gly Val Gln Gly Gln Asn Trp 340 345 350 Ile Val Thr Asn Gly Leu Lys Ala Gly Asp Lys Val Ile Val Asp Gly 355 360 365 Val Ala Lys Val Lys Glu Gly Gln Glu Val Ser Ala Lys Pro Tyr Gln 370 375 380 Ala Gln Pro Ala Asn Pro Gln Gly Ala Ala Pro Asn Ala Thr Lys Pro 385 390 395 400 Ala Gln Ser Gly Lys Pro Gln Ala Glu Gln Lys Ala Ser Asn Ala 405 410 415 <210> SEQ ID NO 70 <211> LENGTH: 656 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 70 Met Asp Ser Ser Ser Ser Ala Thr Arg Ser Glu Ile Ala Leu Gln Asp 1 5 10 15 Thr Pro Gln Ser Val Ser Val Val Thr Gln Lys Val Ile Glu Asp Ile 20 25 30 Gly Ala Thr Arg Leu Val Glu Ala Leu Asp Leu Ala Gly Gly Val Thr 35 40 45 Arg Ala Asn Asn Phe Gly Gly Gln Gly Leu Thr Gly Phe Asn Val Arg 50 55 60 Gly Phe Thr Ser Gly Glu Phe Tyr Arg Asn Gly Phe Pro Ile Asn Arg 65 70 75 80 Gly Tyr Pro Asn Ala Pro Asp Ser Asn Thr Ile Glu Arg Val Asp Val 85 90 95 Leu Arg Gly Pro Ser Ser Ser Leu Tyr Gly Arg Gly Asp Pro Gly Gly 100 105 110 Thr Phe Asn Leu Ile Ser Lys Thr Pro Asn Ser Glu Gln Gln Thr Thr 115 120 125 Leu Gly Ala Gln Leu Asn Ser Glu Gly Leu Tyr Arg Thr Thr Val Asp 130 135 140 Thr Thr Gly Thr Ile Pro Asn Ala Glu Asn Ile Gly Tyr Arg Leu Asn 145 150 155 160 Val Ile Ala Glu Gly Gly Asp Ser Tyr Arg Asp His Val Glu Ser Lys 165 170 175 Arg Tyr Gly Ile Ala Pro Val Ile Gln Trp Gln Ala Thr Asp Ala Thr 180 185 190 Lys Val Thr Phe Glu Ala Asp Ile Leu Arg Asn Gln His Pro Leu Asp 195 200 205 Arg Gly His Thr Arg Tyr Pro Thr Gln Lys Ser Phe Asn Ser Ser Pro 210 215 220 Glu Thr Tyr Leu Trp Glu Thr Gly Lys Tyr Tyr Asn Arg Leu Tyr Asn 225 230 235 240 Asp Asn Asn Met Thr Gln Leu Arg Val Glu His Asp Leu Gly Asn Asp 245 250 255 Trp Lys Leu Asn Ala Gly Val Gln Tyr Leu Asn Gly Lys Leu His Gly 260 265 270 Tyr Ala Val Glu Ala Asn Gly Ile Gln Asn Asp Gly Glu Thr Leu Gly 275 280 285 Arg Asn Tyr Asn Tyr Arg Glu Leu Lys Trp Gln Asp Thr Asp Ala Gln 290 295 300 Ile Asn Leu Thr Gly Asn Phe Gln Leu Leu Gly Leu Ala His Thr Leu 305 310 315 320 Val Thr Gly Leu Glu Tyr Glu Asn Tyr Asp Tyr Lys Ser Tyr Ile Ile 325 330 335 Arg Ser Ser Glu Asp Ile Gly Ser Tyr Ser Ile Asn Ile Tyr Asn Pro 340 345 350 Val Leu Gly Gln Pro Leu Pro Glu Leu Asn Thr Val Thr Thr His Asp 355 360 365 Arg Glu Asn Leu Lys Thr Thr Ala Leu Phe Val Gln Asp Gln Leu Glu 370 375 380 Leu Asn Glu Arg Leu Ser Ala Leu Leu Gly Leu Arg Phe Glu His Tyr 385 390 395 400 Glu His Asp Tyr Gln Asp Leu Arg Pro Gly Lys Pro Asn Trp Asn Thr 405 410 415 Ser His Asp Ala Phe Ile Pro Arg Leu Gly Leu Val Tyr Lys Ala Ser 420 425 430 Asp Asp Leu Ser Leu Tyr Gly Asn Ala Ala Lys Ser Phe Lys Pro Asn 435 440 445 Thr Gly Ala Ser His Ser Gly Glu Gly Phe Asp Pro Glu Glu Gly Met 450 455 460 Ala Tyr Glu Leu Gly Phe Lys Trp Leu Ala Leu Asn Asn Met Leu Ser 465 470 475 480 Val Asp Ser Ala Ile Phe Tyr Ala Asn Lys Glu Asn Val Leu Thr Asn 485 490 495 Asp Pro Leu Phe Pro Asn Tyr Lys Val Ala Ala Gly Glu Val Arg Ser 500 505 510 Arg Gly Ile Glu Leu Asn Ile Ala Gly Gln Ile Thr Pro Ala Trp Lys 515 520 525 Ile Ile Gly Gly Tyr Ala Tyr Thr Asp Ala Glu Val Thr Lys Asp Asn 530 535 540 Thr Leu Gln Lys Gly Thr Ala Leu Ala Asn Ile Pro Lys Asn Ser Phe 545 550 555 560 Asn Leu Leu Asn Ile Tyr Glu Phe Gln Asp Gly Pro Leu Gln Gly Leu 565 570 575 Gly Leu Gly Ile Asn Gln Lys Tyr Ile Asp Lys Arg Ala Gly Gln Thr 580 585 590 Ala Asn Ser Thr Tyr Ile Met Lys Gly Tyr Ala Val Thr Asp Leu Val 595 600 605 Ser Tyr Tyr Gln Ala Thr Pro Lys Leu Arg Leu Asn Leu Asp Val Lys 610 615 620 Asn Ile Phe Asp Lys Val Tyr Asp Glu Ser Ala Phe Asn Leu Tyr Ala 625 630 635 640 Tyr Pro Gly Glu Ser Arg Thr Val Gln Leu Gly Met Ser Tyr Thr Phe 645 650 655 <210> SEQ ID NO 71 <211> LENGTH: 177 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 71 Met Asp Arg Met Arg Gly Glu Asp Asp Tyr Lys Ser Thr Tyr Phe Glu 1 5 10 15 Leu Ser Pro Arg Leu Ser Leu Gly Glu Val Ser Gly Lys Lys Leu Thr 20 25 30 Tyr Gly Pro Ile Lys Asp Val Leu Ile Ser Thr Thr Trp Glu Ser Asn 35 40 45 Thr Gln Asn Gly Asn Asn Phe Asp Asn Phe Leu Tyr Gly Phe Ala Val 50 55 60 Asp Leu Asp Ile Pro Tyr Phe Gln Tyr Ala Asn Leu Asn Phe Tyr Arg 65 70 75 80 Ala Asn Asn Glu Lys Thr Asp Asp Asp Tyr Gln Met Thr Phe Val Tyr 85 90 95 Gly Ile Pro Phe Lys Ile Ala Ser Glu Asp Phe Leu Val Asp Gly Phe 100 105 110 Leu Asp Trp Ser Thr Ala Glu Asp Asp His Ala Ser Glu Leu Asn Trp 115 120 125 Thr Thr Gln Trp Lys Trp Asn Val Gly Lys His Ile Ser Pro Asp Thr 130 135 140 Arg Leu Tyr Leu Gly Ile Glu His Ser Val Trp Asn Asn Lys Phe Gly 145 150 155 160 Ile Lys Gly Ala Asp Glu Asn Asn Val Ser Ala Leu Val Lys Tyr His 165 170 175 Phe <210> SEQ ID NO 72 <211> LENGTH: 581 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 72 Met Tyr Ala Asn Lys Asn Gln Lys Ser Glu Val Thr Tyr Ala Gly Tyr 1 5 10 15 Phe Leu Ser Glu Asn Gly Asn Asn Asn Leu Lys Glu Glu Leu Lys Ala 20 25 30 Asp Ile Ser Ala Leu Phe Ile Pro Thr Gln Asp Asn Gln Ser Ile Arg 35 40 45 Cys Lys Phe Pro Ala Arg Ser Gln Trp Leu Ile Gln Gln Leu Gly Ile 50 55 60 Gln Glu Asn Glu Leu Pro Gln Val Lys Cys Ser Glu Phe Glu Asn Trp 65 70 75 80 Ile Gly Gln Ile Lys Pro Tyr Lys Ala Thr Leu Ile Tyr Ala Thr Asp 85 90 95 Phe Met Gly Asn Pro Ser Ser Met Phe Gly His Thr Leu Leu Arg Leu 100 105 110 Asp Pro Lys Asp Gln Gln Gln Leu Asn Leu Val Ser Tyr Ala Val Asn 115 120 125 Tyr Ala Ala Thr Val Ala Gly Asn Asp Asn Trp Ser Tyr Ala Trp Lys 130 135 140 Gly Leu Thr Gly Gln Tyr Pro Gly Glu Tyr Ser Leu Met Pro Tyr Tyr 145 150 155 160 Arg Lys Val Lys Glu Tyr Gly Asp Phe Glu Ser Arg Asp Leu Trp Glu 165 170 175 Tyr Glu Leu Asn Leu Ser Pro Glu Glu Thr Arg Phe Leu Val Ser His 180 185 190 Ile Trp Glu Met Gln His Val Ser Phe Pro Tyr Tyr Phe Val Ser Asp 195 200 205 Asn Cys Ala Tyr Arg Leu Leu Gly Leu Val Asp Leu Val Lys Pro Glu 210 215 220 Ser His Leu Gln Glu Lys Phe Asn Tyr Ala Ser Ile Pro Met Glu Thr 225 230 235 240 Ile Lys Ala Met Gln Gln Gln Gly Leu Thr Lys Ala Pro Val Tyr Arg 245 250 255 Pro Ala Leu Glu Thr Gln Leu Leu Ala Gln Ala His Gln His Gly Ala 260 265 270 Ser Leu Ala Lys Val Ala His Gln Leu Ala Met Lys Pro Ile Lys Glu 275 280 285 Ser Ser Glu Thr Leu Lys Ser Phe Ser Pro Ser Asp Gln Ala Lys Ile 290 295 300 Leu Glu Met Ala Tyr Asp Asp Leu Tyr Leu Gln Phe Ile Gly Arg Lys 305 310 315 320 Val Glu Glu Ser Phe Ala Gln Pro Gln Leu Arg Gln Leu Leu Ala Leu 325 330 335 Arg Ser Gln Ile Asp Leu Asp Lys Gln Arg Gln Glu Pro Lys Arg Pro 340 345 350 Ser Thr Glu Pro Thr Gln Gly His Asn Ala Arg Asn Val Ser Leu Lys 355 360 365 Leu Gly Glu Val Gln Gly Asp Lys Phe Ile Glu Ile Gly His Arg Gln 370 375 380 Ala Tyr His Asp Leu Ile Asp Pro Gln Gly Gly Tyr Arg Ala Gly Thr 385 390 395 400 Gln Leu Leu Phe Leu Asn Gly Asn Ala Gln Trp Arg Asp Asp His Leu 405 410 415 Lys Leu Glu Arg Leu Asp Leu Leu Glu Val Asn Ser Tyr Asn Pro Ile 420 425 430 Gln Pro Phe Lys Thr Pro Leu Thr Trp Gly Phe Asn Leu Gly Trp Arg 435 440 445 Gln Glu Ala Val His Asp Gly Val Tyr Ser Asp Glu Lys Gln His Gly 450 455 460 Val Ala Ser Phe Asn Ala Gln Val Gly Tyr Ser Leu Ala Asp Tyr Glu 465 470 475 480 Arg Lys His Ile Cys Tyr Gly Gln Val Gln Thr Tyr Val Gln Ala Gly 485 490 495 Ser Asn Leu Asp Lys Gly Trp Arg Val Gly Val Gly Pro Thr Leu Gly 500 505 510 Cys Met Asn Gln Trp Leu Glu Lys Phe Asn Thr Val Val Gln Val Glu 515 520 525 Leu Pro Tyr Trp Glu Asp Gln Asn Gln Trp Asn Leu Arg Leu Asn Thr 530 535 540 Gln Trp Gln Tyr Ala Ile Asn Ser Asn Asn Ala Ile Arg Phe Asn Trp 545 550 555 560 Asp Tyr Glu Lys Gln Asn His Leu Asp Trp Met Lys Ser Ser Leu Gly 565 570 575 Tyr Val Trp Phe Phe 580 <210> SEQ ID NO 73 <211> LENGTH: 205 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 73 Met Arg Gly Asn Asn Val Asn Leu Lys Thr Val Ser Gly Ser Ala Val 1 5 10 15 Glu Leu Ser Glu Val Ala Phe Gly Arg Glu Phe Asn Glu Ala Leu Val 20 25 30 His Gln Val Val Thr Ala Tyr Leu Ala Gly Gly Arg Gln Gly Thr Arg 35 40 45 Ala Gln Lys Ser Arg Ala Glu Val Ser Gly Gly Gly Lys Lys Pro Phe 50 55 60 Arg Gln Lys Gly Thr Gly Arg Ala Arg Ala Gly Ser Ile Arg Ser Pro 65 70 75 80 Ile Trp Val Gly Gly Gly Lys Thr Phe Ala Ala Arg Pro Gln Asp Trp 85 90 95 Ser Gln Lys Val Asn Arg Lys Met Tyr Arg Gly Ala Met Gln Cys Ile 100 105 110 Leu Ala Glu Leu Val Arg Gln Asp Arg Leu Val Leu Val Glu Glu Phe 115 120 125 Ala Val Ala Ala Pro Lys Thr Lys Glu Leu Leu Ala Lys Leu Asn Asp 130 135 140 Leu Asn Ala Ala Arg Ala Leu Ile Val Thr Asp Ala Val Asp Glu Asn 145 150 155 160 Leu Tyr Leu Ala Ala Arg Asn Leu Pro His Val Asp Val Val Asp Ala 165 170 175 Thr Ala Ile Asp Pro Val Ser Leu Ile Ala Phe Asp Lys Val Val Met 180 185 190 Ser Val Ala Ala Ala Lys Lys Ile Glu Val Glu Leu Gly 195 200 205 <210> SEQ ID NO 74 <211> LENGTH: 152 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 74 Met Lys Gly Ser Lys Gly Thr Leu Ser Phe Asn Leu His Ala Leu Val 1 5 10 15 Glu Leu Lys Gln Glu Glu Gly Lys Leu Gln Leu Ala Pro Ala Lys Glu 20 25 30 Ser Lys Asp Ala Trp Met Gln Ala Gly Thr Ala Arg Ala Val Leu Asn 35 40 45 Asn Leu Val Lys Gly Val Ser Glu Gly Phe Glu Arg Lys Leu Gln Leu 50 55 60 Val Gly Val Gly Tyr Lys Ala Ala Val Lys Gly Thr Val Val Asn Leu 65 70 75 80 Asn Leu Gly Tyr Ser His Pro Ile Asp Tyr Ala Leu Pro Glu Gly Val 85 90 95 Thr Ala Glu Thr Pro Thr Ala Thr Glu Ile Ile Leu Lys Ser Ala Asn 100 105 110 Lys Gln Leu Leu Gly Gln Val Ala Ala Glu Ile Arg Ala Tyr Arg Ser 115 120 125 Pro Glu Pro Tyr Lys Gly Lys Gly Val Arg Tyr Ser Asp Glu Val Ile 130 135 140 Leu Arg Lys Glu Ala Lys Lys Lys 145 150 <210> SEQ ID NO 75 <211> LENGTH: 221 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 75 Met Thr Asn Leu Thr Asp Tyr Val Val Leu Asn Thr Ser Val Ala Ser 1 5 10 15 Gly Glu Gln Asp Val Asn Ala Phe Gln Ser Phe Asn Tyr Leu Ala Ala 20 25 30 Tyr Asn Ala Ser Asn Lys Ala Lys Val Ala Ala Val Ala Thr Thr Tyr 35 40 45 Leu Glu Pro Met Gly Ile Tyr Ala Asn Lys Val Lys Thr Val Asp Glu 50 55 60 Phe Pro Gln Gly Ala Thr Ile Ala Ile Pro Asn Asp Thr Ala Asn Glu 65 70 75 80 Ala Arg Ala Leu Thr Leu Leu Gln Ser Ala Lys Leu Ile Lys Leu Lys 85 90 95 Pro Asp Phe Asp Pro Val Lys Gly Thr Thr Asn Asp Val Val Glu Asn 100 105 110 Pro Lys Asn Leu Gln Leu Lys Pro Ile Gln Met Thr Thr Ala Val Arg 115 120 125 Val Lys Asn Asp Val Asp Ala Ile Val Leu Gly Asn Thr Leu Ala Leu 130 135 140 Glu Gly Gly Leu Asn Val Met Lys Asp Ala Ile Phe Arg Glu Pro Ile 145 150 155 160 Asp Gln Ser Thr Lys Leu Tyr Val Asn Leu Leu Gly Val Ala Glu Ala 165 170 175 Asn Lys Asn Asp Pro Ile Tyr Thr Lys Leu Gly Glu Leu Tyr His Leu 180 185 190 Pro Lys Val Gln Lys Phe Val Asn Glu Lys Phe Gly Gly Thr Lys Val 195 200 205 Glu Val Asn Lys Pro Val Ser Glu Phe Ala Asp Ile Lys 210 215 220 <210> SEQ ID NO 76 <211> LENGTH: 99 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 76 Met Ala Thr Ala Val Arg Val Lys Asp Glu Val Asp Ala Ile Val Leu 1 5 10 15 Gly Asn Thr Leu Ala Met Glu Gly Gly Leu Asn Val Leu Lys Asp Ser 20 25 30 Ile Tyr Tyr Glu Pro Val Asp Gln Ser Thr Lys Leu Asn Val Asn Ile 35 40 45 Leu Ala Thr Ala Glu Ser Arg Lys Asp Asp Pro Val Leu Gln Lys Val 50 55 60 Gly Gln Leu Tyr His Thr Glu Ala Val Lys Lys Tyr Val Glu Gln His 65 70 75 80 Phe Gly Gly Thr Lys Val Asp Val Asn Gln Pro Ile Ser Tyr Leu Thr 85 90 95 Gln Ala Lys <210> SEQ ID NO 77 <211> LENGTH: 169 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 77 Met Val Asn Glu Thr Met Lys His Gln Phe Lys Phe Asn Pro Leu Ala 1 5 10 15 Thr Ala Ile Phe Thr Leu Leu Cys Ser Gly Ser Ile Gln Ser Ser Tyr 20 25 30 Ala Glu Ser Ala Gly Val Val Ser Asn Ile Asp Asn Asn Gln Leu Lys 35 40 45 Ala Ser Ile Lys Glu Ala Tyr Pro Gly Gln Glu Phe Phe Gln Gln Tyr 50 55 60 Tyr Val Asp Lys Ser Ala Pro Glu Ala Gln Leu Arg Asn Asn Lys Tyr 65 70 75 80 Leu Ser Ser Ala Phe Cys Gln Gly Thr Trp Ile Thr Pro Ile Asn Pro 85 90 95 Glu Thr Lys Ala Leu Asp Ala Asp Lys Ala Thr Ser Val Val Thr Ala 100 105 110 Asp Tyr Gly His Tyr Asn Pro Ala Gly Asp Ser Val Leu Glu Gly Asn 115 120 125 Val Val Ile Asp Gln Glu Gly Arg Thr Val Arg Ala Asp Lys Val Thr 130 135 140 Ile Asp Lys Thr Gln Thr Phe Ala His Ala Gln Gly Arg Val Gln Leu 145 150 155 160 Ala Gln Gly Gly Leu Leu Ser Thr Lys 165 <210> SEQ ID NO 78 <211> LENGTH: 236 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 78 Met Ser Arg Gly Thr Arg Thr Phe Glu Ile Tyr Arg Tyr Asp Pro Asp 1 5 10 15 Lys Asp Lys Ala Pro Tyr Met Gln Thr Phe Lys Leu Glu Leu Thr Asp 20 25 30 Lys His Arg Met Leu Leu Asp Ala Leu Leu Ala Leu Lys Val Gln Asp 35 40 45 Glu Thr Leu Thr Phe Arg Arg Ser Cys Arg Glu Gly Ile Cys Gly Ser 50 55 60 Asp Gly Val Asn Ile Asn Gly Lys Asn Gly Leu Ala Cys Leu Trp Asn 65 70 75 80 Leu Asn Asp Leu Pro Glu Lys Ile Val Ile Arg Pro Leu Pro Gly Leu 85 90 95 Pro Val Ile Lys Asp Leu Val Val Asp Met Asn Gln Phe Tyr Asp Gln 100 105 110 Tyr Asp Lys Ile Gln Pro Phe Leu Ile Asn Asn Gln Pro Ala Pro Pro 115 120 125 Lys Glu Arg Leu Gln Ser Pro Glu Glu Arg Glu His Leu Asn Gly Leu 130 135 140 Tyr Glu Cys Ile Leu Cys Ala Cys Cys Ser Thr Ser Cys Pro Ser Phe 145 150 155 160 Trp Trp Asn Pro Asp Lys Phe Leu Gly Pro Ser Ala Leu Leu Asn Ala 165 170 175 Tyr Arg Phe Ile Ile Asp Ser Arg Asp Thr Ala Thr Gln Asp Arg Leu 180 185 190 Ser Arg Leu Asp Asp Pro Phe Ser Leu Phe Arg Cys Lys Gly Ile Met 195 200 205 Asn Cys Val Ser Val Cys Pro Lys Gly Leu Asn Pro Thr Lys Ala Ile 210 215 220 Gly His Ile Arg Asn Met Leu Phe Asp Gln Ala Gly 225 230 235 <210> SEQ ID NO 79 <211> LENGTH: 300 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 79 Met Leu Gly Lys Asp Gln Pro Val Ile Leu Gln Leu Leu Glu Val Pro 1 5 10 15 Val Glu Lys Ala Gln Gln Ala Leu Lys Gly Val Met Met Glu Leu Asp 20 25 30 Asp Cys Ala Phe Pro Leu Leu Ala Gly Met Ile Gly Thr Asp Asp Pro 35 40 45 Lys Val Ala Phe Lys Asp Ala Asp Tyr Ala Leu Leu Val Gly Ser Arg 50 55 60 Pro Arg Gly Pro Gly Met Glu Arg Ala Asp Leu Leu Lys Val Asn Gly 65 70 75 80 Glu Ile Phe Ile Gly Gln Gly Gln Ala Leu Asn Glu Val Ala Ser Arg 85 90 95 Asp Val Lys Val Leu Val Val Gly Asn Pro Ala Asn Thr Asn Ala Tyr 100 105 110 Ile Ala Met Lys Ser Ala Pro Asp Leu Pro Ala Lys Asn Phe Thr Ala 115 120 125 Met Leu Arg Leu Asp His Asn Arg Ala Leu Thr Gln Val Ala Gln Lys 130 135 140 Ala Gly Val Ala Val Ala Asp Ile Glu Lys Leu Thr Val Trp Gly Asn 145 150 155 160 His Ser Pro Thr Met Tyr Ala Asp Tyr Arg Phe Ala Thr Ala Asn Gly 165 170 175 Glu Ser Leu Lys Asp Lys Ile Asn Asp Pro Ala Trp Asn Lys Asp Val 180 185 190 Phe Leu Pro Thr Val Gly Lys Arg Gly Ala Ala Ile Ile Glu Ala Arg 195 200 205 Gly Leu Ser Ser Ala Ala Ser Ala Ala Asn Ala Ala Ile Asp His Met 210 215 220 Arg Asp Trp Ala Leu Gly Thr Asn Gly Lys Trp Val Thr Met Gly Val 225 230 235 240 Pro Ser Asp Gly Ser Tyr Gly Ile Pro Glu Gly Val Met Phe Gly Phe 245 250 255 Pro Val Thr Thr Glu Asn Gly Glu Tyr Lys Ile Val Gln Gly Leu Glu 260 265 270 Ile Asp Glu Phe Ser Arg Glu Arg Ile Asn Phe Thr Leu Asn Glu Leu 275 280 285 Glu Glu Glu Arg Ala Ala Ile Ala Asp Met Val Lys 290 295 300 <210> SEQ ID NO 80 <211> LENGTH: 373 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 80 Met Gly Glu Pro Val Ser Arg Asp Glu Val Ile Cys Asp Ile Glu Thr 1 5 10 15 Asp Lys Val Val Leu Glu Val Val Ala Pro Ala Asp Gly Ser Leu Val 20 25 30 Ala Ile Ile Lys Gly Glu Gly Asp Thr Val Leu Ser Asp Glu Val Ile 35 40 45 Ala Gln Phe Glu Ala Gly Ala Gly Ala Ala Ala Ala Ala Pro Ala Ala 50 55 60 Val Glu Gln Ala Val Ala Gln Thr Gln Ala Gly Ala Ala Pro Val Val 65 70 75 80 Glu Arg Asn Glu Thr Val Ser Asp Gln Ala Pro Ala Val Arg Lys Ala 85 90 95 Leu Thr Glu Ser Gly Ile Ala Ala Ser Asp Val Gln Gly Thr Gly Arg 100 105 110 Gly Gly Arg Ile Thr Lys Glu Asp Val Ala Asn His Gln Ala Lys Pro 115 120 125 Ala Ala Asn Val Thr Pro Leu Ser Val Ala Val Gly Glu Arg Ile Glu 130 135 140 Lys Arg Val Pro Met Thr Arg Leu Arg Lys Arg Val Ala Glu Arg Leu 145 150 155 160 Leu Ala Ala Thr Gln Glu Thr Ala Met Leu Thr Thr Phe Asn Glu Val 165 170 175 Asn Met Lys Pro Ile Met Glu Leu Arg Lys Gln Tyr Lys Asp Ala Phe 180 185 190 Glu Lys Arg His Gly Ala Arg Leu Gly Phe Met Ser Phe Phe Val Lys 195 200 205 Ala Ala Thr Glu Ala Leu Lys Arg Tyr Pro Ala Val Asn Ala Ser Ile 210 215 220 Asp Gly Asp Asp Ile Val Tyr His Gly Tyr Tyr Asp Ile Gly Val Ala 225 230 235 240 Val Ser Ser Asp Arg Gly Leu Val Val Pro Val Leu Arg Asp Thr Asp 245 250 255 Arg Met Ser Tyr Ala Glu Val Glu Ala Gly Ile Ala Ala Tyr Ala Ala 260 265 270 Lys Ala Arg Asp Gly Lys Leu Ser Ile Glu Glu Met Thr Gly Gly Thr 275 280 285 Phe Thr Ile Thr Asn Gly Gly Thr Phe Gly Ser Leu Leu Ser Thr Pro 290 295 300 Ile Leu Asn Gln Pro Gln Thr Gly Ile Leu Gly Met His Lys Ile Gln 305 310 315 320 Glu Arg Pro Met Ala Val Asn Gly Gln Val Glu Ile Leu Pro Met Met 325 330 335 Tyr Leu Ala Leu Ser Tyr Asp His Arg Met Ile Asp Gly Lys Glu Ala 340 345 350 Val Gly Phe Leu Val Ala Ile Lys Glu Leu Leu Glu Glu Pro Ala Lys 355 360 365 Leu Ile Leu Asp Leu 370 <210> SEQ ID NO 81 <211> LENGTH: 468 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 81 Met Ser Phe Ser Met Thr Lys Leu Ser Ala Ala Leu Leu Leu Thr Ser 1 5 10 15 Ser Leu Val Gly Cys Ala Ala Val Val Lys Thr Pro Tyr Gln Ala Pro 20 25 30 Ala Val Gln Val Pro Gly Ser Phe Gln Tyr Asp Lys Ala Lys Ala Lys 35 40 45 Thr Ala Ser Val Glu Gln Tyr Ser Asp Arg Trp Trp Thr Leu Phe Gly 50 55 60 Asp Thr Gln Leu Asn Gln Leu Val Thr Asn Val Leu Glu Arg Asn Ser 65 70 75 80 Asp Leu Ala Val Ala Gly Ile Thr Leu Gln Gln Ala Arg Leu Gln Ala 85 90 95 Asp Leu Thr Ala Asn Lys Gln Gly Leu Arg Thr Ser Ser Ser Val Ser 100 105 110 Thr Gly His Ser Phe Asp Leu Asn Ser Gly Asp Asp Ser Ala Lys Gly 115 120 125 Leu Ser Met Ser Ala Gly Val Ser Tyr Glu Leu Asp Leu Phe Gly Lys 130 135 140 Leu Ala Arg Gln Thr Glu Ala Ser Lys Trp Glu Ala Leu Ala Thr Glu 145 150 155 160 Gln Asp Leu Gln Ala Thr Gly Gln Ser Leu Ile Ala Thr Thr Ala Lys 165 170 175 Leu Tyr Trp Gln Leu Gly Tyr Leu Asn Glu Arg Tyr Ala Thr Ala Gln 180 185 190 Gln Ser Leu Ala Thr Ser Gln Lys Leu Tyr Gln Leu Val Gln Thr Gln 195 200 205 Tyr Lys Ala Gly Ala Val Ser Gly Leu Asp Leu Thr Gln Ala Glu Gln 210 215 220 Ser Val Gln Ser Gln Lys Ala Ser Leu Ser Gln Ile Glu Gln Gln Leu 225 230 235 240 Val Glu Thr Arg Thr Ala Ile Ala Val Leu Leu His Glu Pro Leu Gln 245 250 255 Gln Leu Asn Ile Gln Glu Pro Gln Arg Leu Pro Arg Thr Ala Leu Pro 260 265 270 Ala Ile Gly Ala Gly Leu Pro Ala Asp Ile Leu Ser Arg Arg Pro Asp 275 280 285 Leu Gln Ala Ala Glu Leu Arg Leu Arg Lys Ala Leu Ala Thr Lys Asp 290 295 300 Ala Thr Lys Ala Ser Tyr Tyr Pro Ser Ile Ser Leu Thr Ser Ser Leu 305 310 315 320 Gly Ser Ser Ser Thr Ser Leu Thr Glu Leu Leu Arg Asn Pro Ala Leu 325 330 335 Thr Leu Gly Ala Ser Leu Ser Leu Pro Phe Leu Gln Tyr Asn Asp Met 340 345 350 Lys Lys Asp Ile Ala Ile Ser Asn Leu Asp Tyr Glu Lys Ala Ile Ile 355 360 365 Gln Tyr Arg Gln Thr Leu Tyr Gln Ala Phe Ala Asp Val Glu Asn Ala 370 375 380 Leu Ser Ser Arg Thr Glu Leu Asp Lys Gln Val Ala Leu Gln Glu Arg 385 390 395 400 Asn Val Glu Leu Ala Glu Lys Thr Glu Arg Leu Thr Glu Val Arg Tyr 405 410 415 Arg Tyr Gly Ala Val Ala Leu Lys Thr Leu Leu Asp Ala Gln Gln Thr 420 425 430 Thr Arg Thr Ala Arg Leu Ser Leu Val Glu Thr Lys Gln Ser Gln Tyr 435 440 445 Asn Ala Tyr Val Thr Leu Met Gln Ala Leu Gly Gly Ser Pro Val Lys 450 455 460 Glu Leu Pro Gln 465 <210> SEQ ID NO 82 <211> LENGTH: 358 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 82 Met Ala Tyr Ala Asp Thr Leu Ala Pro Val Lys Pro Ala Ser Val Asp 1 5 10 15 Ala Cys Val Ala Leu Ala Ser Asn Ala Asp Arg Leu Ala Cys Tyr Asp 20 25 30 Ala Val Phe Lys Pro Ser Ala Leu Pro Val Val Gln Ala Ala Val Val 35 40 45 Pro Glu Pro Val Lys Lys Ile Asp Lys Pro Val Val Gln Pro Glu Thr 50 55 60 Phe Lys Glu Lys Val Val Asp Lys Val Ser Asn Ile Lys Val Ile Gly 65 70 75 80 Lys Ala Pro Thr Leu Glu Pro Thr Thr Ser Leu Leu Asp Gln Arg Trp 85 90 95 Glu Leu Ser Glu Lys Ser Lys Leu Gly Val Trp Asn Ile Arg Ala Tyr 100 105 110 Gln Pro Val Tyr Leu Leu Pro Val Phe Trp Thr Ser Asp Lys Asn Glu 115 120 125 Phe Pro Ser Ser Pro Asn Pro Asn Asn Thr Val Thr Glu Ala Gln Asn 130 135 140 Leu Lys Ser Thr Glu Ser Lys Phe Gln Ile Ser Leu Lys Thr Lys Ala 145 150 155 160 Trp Glu Asn Ile Phe Gly Asn Asn Gly Asp Leu Trp Val Gly Tyr Thr 165 170 175 Gln Ser Ser Arg Trp Gln Thr Phe Asn Ala Glu Glu Ser Arg Pro Phe 180 185 190 Arg Glu Thr Asn Tyr Glu Pro Glu Ala Ser Leu Met Phe Arg Thr Asn 195 200 205 Tyr Glu Leu Leu Gly Leu Asp Gly Arg Leu Leu Gly Val Thr Leu Asn 210 215 220 His Gln Ser Asn Gly Arg Ser Asp Pro Leu Ser Arg Ser Trp Asn Arg 225 230 235 240 Val Ile Phe Asn Val Gly Leu Glu Arg Gly Asn Phe Ala Leu Met Leu 245 250 255 Arg Pro Trp Ile Arg Leu Glu Glu Asp Ser Lys Asp Asp Asn Asn Pro 260 265 270 Asp Met Glu Asp Tyr Ile Gly Arg Gly Asp Leu Thr Ala Phe Tyr Lys 275 280 285 Trp Lys Gln Asn Asp Phe Ser Leu Met Leu Arg His Ser Leu Lys Gly 290 295 300 Gly Asp Asp Ser His Gly Ala Val Gln Phe Asp Trp Ala Phe Pro Ile 305 310 315 320 Ser Gly Lys Leu Arg Gly His Phe Gln Leu Phe Asn Gly Tyr Gly Glu 325 330 335 Ser Leu Ile Asp Tyr Asn His Arg Ala Thr Tyr Ala Gly Leu Gly Val 340 345 350 Ser Leu Met Asn Trp Tyr 355 <210> SEQ ID NO 83 <211> LENGTH: 108 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 83 Met Glu Gly Leu Ser Val Thr Tyr Asn Gly Ser Thr Asp Thr Ala Ile 1 5 10 15 Ile Lys Gly Gln Val Gln Ser Gln Ala Asp Lys Glu Lys Ile Ile Leu 20 25 30 Ile Val Gly Asn Val Asp His Val Ala Gln Val Asp Asp Gln Met Thr 35 40 45 Val Ala Thr Pro Glu Pro Glu Ser Lys Phe Tyr Thr Val Lys Ser Gly 50 55 60 Asp Asn Leu Ser Lys Ile Ala Lys Glu Phe Tyr Gly Asp Ala Asn Gln 65 70 75 80 Tyr Gln Lys Ile Phe Glu Ala Asn Lys Pro Met Leu Lys Asp Pro Asp 85 90 95 Glu Ile Phe Pro Gly Gln Val Leu Arg Ile Pro Gln 100 105 <210> SEQ ID NO 84 <211> LENGTH: 291 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 84 Met Thr Ala Ile Thr Ala Ser Met Val Lys Glu Leu Arg Asp Arg Thr 1 5 10 15 Gly Leu Ala Met Met Glu Cys Lys Lys Ala Leu Thr Glu Ala Asn Gly 20 25 30 Asp Ile Glu Leu Ala Ile Asp Asn Leu Arg Lys Ser Gly Gln Ala Lys 35 40 45 Ala Ala Lys Lys Ala Gly Asn Ile Ala Ala Asp Gly Ala Ile Thr Ile 50 55 60 Val Gln Asp Gly Asn Lys Ala Ile Leu Val Glu Val Asn Cys Gln Thr 65 70 75 80 Asp Phe Val Ala Lys Asp Glu Asn Phe Ser Asn Phe Ala His Thr Val 85 90 95 Ala Ala Ala Ala Leu Ala Ala Gly Glu Thr Asp Ala Ala Lys Ile Ala 100 105 110 Glu Leu Lys Leu Ala Asp Gly Gln Ser Val Glu Glu Ala Arg Ile Ala 115 120 125 Leu Val Gln Lys Ile Gly Glu Asn Ile Gln Val Arg Arg Ala Lys Ile 130 135 140 Val Glu Gly Glu Gln Leu Ala Ile Tyr Lys His Gly Leu Lys Ile Gly 145 150 155 160 Val Val Val Ser Tyr Thr Gly Asp Ala Asp Thr Gly Lys Gly Ile Ala 165 170 175 Met His Val Ala Ala Phe Asn Pro Val Ala Val Asn Ala Glu Ala Val 180 185 190 Pro Ala Asp Leu Ile Ala Lys Glu Lys Glu Ile Ala Glu Ala Lys Ala 195 200 205 Leu Glu Ser Gly Lys Pro Ala Asn Ile Val Glu Lys Met Val Thr Gly 210 215 220 Ser Val Glu Lys Tyr Leu Asn Glu Val Ala Leu Asp Arg Gln Met Tyr 225 230 235 240 Val Ile Asp Asn Glu Lys Lys Val Ala Asp Val Leu Lys Ala Thr Gly 245 250 255 Thr Asn Val Ala Asn Phe Val Arg Phe Glu Val Gly Glu Gly Ile Glu 260 265 270 Lys Lys Ala Glu Leu Ser Phe Ala Glu Glu Val Ala Ala Ala Gln Ala 275 280 285 Ala Ala Lys 290 <210> SEQ ID NO 85 <211> LENGTH: 170 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 85 Met Thr Gly Cys Ala Ser Arg Lys Pro Ala Thr Thr Ala Thr Thr Gly 1 5 10 15 Thr Thr Asn Pro Ser Thr Val Asn Thr Thr Gly Leu Ser Glu Asp Ala 20 25 30 Ala Leu Asn Ala Gln Asn Leu Ala Gly Ala Ser Ser Lys Gly Val Thr 35 40 45 Glu Ala Asn Lys Ala Ala Leu Ala Lys Arg Val Val His Phe Asp Tyr 50 55 60 Asp Ser Ser Asp Leu Ser Thr Glu Asp Tyr Gln Thr Leu Gln Ala His 65 70 75 80 Ala Gln Phe Leu Met Ala Asn Ala Asn Ser Lys Val Ala Leu Thr Gly 85 90 95 His Thr Asp Glu Arg Gly Thr Arg Glu Tyr Asn Met Ala Leu Gly Glu 100 105 110 Arg Arg Ala Lys Ala Val Gln Asn Tyr Leu Ile Thr Ser Gly Val Asn 115 120 125 Pro Gln Gln Leu Glu Ala Val Ser Tyr Gly Lys Glu Ala Pro Val Asn 130 135 140 Pro Gly His Asp Glu Ser Ala Trp Lys Glu Asn Arg Arg Val Glu Ile 145 150 155 160 Asn Tyr Glu Ala Val Pro Pro Leu Leu Lys 165 170 <210> SEQ ID NO 86 <211> LENGTH: 144 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 86 Met Lys Lys Ile Ile Phe Leu Gly Leu Ala Leu Val Ser Leu Thr Ala 1 5 10 15 Cys Ser Ser Val Gln His Lys Asp Ser Thr Pro Pro Lys Ile Gly Ser 20 25 30 Pro Asn Pro Ala Ser Gln Tyr Cys Val Glu Gln Gly Gly Lys Leu Glu 35 40 45 Ile Arg Asn Glu Ala Asn Gly Gln Val Gly Tyr Cys His Leu Pro Asn 50 55 60 Gly Gln Val Val Glu Glu Trp Lys Leu Phe Arg Asp Asn Gln Ala Asn 65 70 75 80 Cys Val Ser Glu Glu Ala Gln Lys Leu Val Gly Leu Ser Gly Leu Thr 85 90 95 Asp Asp Gln Ile Lys Gln Lys Thr Lys Ser Glu Ile Val Arg Lys Val 100 105 110 Ala Pro Gly Gln Pro Met Thr Met Asp Tyr Arg Ser Asn Arg Val Thr 115 120 125 Val Thr Ile Asp Pro Thr Ser Lys Lys Ile Thr Gln Ala Thr Cys Gly 130 135 140 <210> SEQ ID NO 87 <211> LENGTH: 249 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 87 Met Lys Val Leu Arg Val Leu Val Thr Thr Thr Ala Leu Leu Ala Ala 1 5 10 15 Gly Ala Ala Met Ala Asp Glu Ala Val Val His Asp Ser Tyr Ala Phe 20 25 30 Asp Lys Asn Gln Leu Ile Pro Val Gly Ala Arg Ala Glu Val Gly Thr 35 40 45 Thr Gly Tyr Gly Gly Ala Leu Leu Trp Gln Ala Asn Pro Tyr Val Gly 50 55 60 Leu Ala Leu Gly Tyr Asn Gly Gly Asp Ile Ser Trp Thr Asp Asp Val 65 70 75 80 Ser Val Asn Gly Thr Lys Tyr Asp Leu Asp Met Asp Asn Asn Asn Val 85 90 95 Tyr Leu Asn Ala Glu Ile Arg Pro Trp Gly Ala Ser Thr Asn Pro Trp 100 105 110 Ala Gln Gly Leu Tyr Ile Ala Ala Gly Ala Ala Tyr Leu Asp Asn Asp 115 120 125 Tyr Asp Leu Ala Lys Arg Ile Gly Asn Gly Asp Thr Leu Ser Ile Asp 130 135 140 Gly Lys Asn Tyr Gln Gln Ala Val Pro Gly Gln Glu Gly Gly Val Arg 145 150 155 160 Gly Lys Met Ser Tyr Lys Asn Asp Ile Ala Pro Tyr Leu Gly Phe Gly 165 170 175 Phe Ala Pro Lys Ile Ser Lys Asn Trp Gly Val Phe Gly Glu Val Gly 180 185 190 Ala Tyr Tyr Thr Gly Asn Pro Lys Val Glu Leu Thr Gln Tyr Asn Leu 195 200 205 Ala Pro Val Thr Gly Asn Pro Thr Ser Ala Gln Asp Ala Val Asp Lys 210 215 220 Glu Ala Asn Glu Ile Arg Asn Asp Asn Lys Tyr Glu Trp Met Pro Val 225 230 235 240 Gly Lys Val Gly Val Asn Phe Tyr Trp 245 <210> SEQ ID NO 88 <211> LENGTH: 999 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 88 Met Arg Ala Val Glu Gly Asp Arg Leu Leu Ile Leu Lys His Gly Asp 1 5 10 15 Val Trp Lys Arg Met Ala Val Gly Phe Lys Met Asp Leu Asn His Trp 20 25 30 Asp Pro Arg Ile Glu Ala Gln Arg Ser Trp Phe Ile Ser Arg Gln Pro 35 40 45 Tyr Leu Asp Arg Leu Ser Ala Arg Ala Ser Arg Tyr Leu Tyr His Thr 50 55 60 Val Lys Glu Ala Glu Arg Arg Gly Leu Pro Thr Glu Leu Ala Leu Leu 65 70 75 80 Pro Val Ile Glu Ser Ser Tyr Asp Pro Ala Ala Thr Ser Ser Ala Ala 85 90 95 Ala Ala Gly Leu Trp Gln Phe Ile Pro Ser Thr Gly Arg Ile Tyr Gly 100 105 110 Leu Gln Gln Thr Gly Met Tyr Asp Gly Arg Arg Asp Val Val Glu Ser 115 120 125 Thr Arg Ala Ala Tyr Glu Phe Leu Gly Ser Leu Tyr Asn Gln Phe Gly 130 135 140 Ser Trp Glu Leu Ala Leu Ala Ala Tyr Asn Ala Gly Pro Gly Arg Ile 145 150 155 160 Gln Gln Ala Ile Asn Arg Asn Gln Ala Ala Gly Leu Pro Thr Asp Tyr 165 170 175 Trp Ser Leu Lys Leu Pro Gln Glu Thr Met Asn Tyr Val Pro Arg Phe 180 185 190 Leu Ala Val Ala Gln Ile Ile Lys Asn Pro Arg Ala Tyr Gly Val Ser 195 200 205 Leu Pro Pro Ile Ala Asn Arg Pro His Phe Arg Glu Val Thr Leu Ser 210 215 220 Ala Pro Leu Ser Leu Asn Glu Ile Ala Ser Val Thr Gly Leu Ser Arg 225 230 235 240 Ala Glu Leu Tyr Ala Leu Asn Pro Gly Tyr Arg Gly Glu Thr Val Asp 245 250 255 Pro Ala Ser Pro Met Arg Ile Leu Ile Pro Ala Asp Ile Ser Pro Ser 260 265 270 Val Asp Asn Lys Leu Lys Gly Met Lys Ala Gly Gly Ser Ser Gly Trp 275 280 285 Trp Ala Ser Val Thr Ser Pro Ser Lys Pro Thr Thr Thr Thr Ser Thr 290 295 300 Ser Val Thr Val Arg Thr Thr Pro Ser Thr Pro Ala Gln Pro Val Arg 305 310 315 320 Pro Ser Thr Pro Ala Lys Thr Ser Ser Ser Ser Val Thr Val Lys Thr 325 330 335 Ala Thr Pro Arg Gly Ser Asp Ala Leu Ala Ala Phe Ala Ala Ser Ala 340 345 350 Asp Val Pro Ser Ala Pro Arg Ile Pro Val Ala Val Thr Pro Ala Ala 355 360 365 Asn Ile Lys Pro Val Arg Thr Glu Pro Pro Ile Ser Ala Thr Glu Arg 370 375 380 Glu Lys Ile Leu Ala Ala Val Arg Ala Glu Gly Glu Lys Glu Thr Val 385 390 395 400 Asp Gln Ala Leu Glu Pro Gln Ala Thr Gln Ala Glu Lys Asp Gln Val 405 410 415 Val Ala Glu Leu Lys Ala Leu Ala Pro Gln Gly Thr Glu Ile Val Asp 420 425 430 Pro Tyr Asp Gly Lys Ile Lys Leu Thr Ala Ile Gln Thr Ser Gln Ser 435 440 445 Val Ala Glu Gln Gln Gly Lys Glu Val Ser Lys Gly Phe Ala Tyr Pro 450 455 460 Lys Thr Leu Ala Glu Asp Ala Thr Leu Ala Asn Ser Glu Asp Ala Gln 465 470 475 480 Arg Asn Lys Asp Lys Pro Tyr Ile Lys Thr Asp Thr Asp Val Val Val 485 490 495 Val Gln Pro Lys Gly Lys Arg Ser Thr Tyr Thr Val Gln Pro Gly Asp 500 505 510 Thr Leu Ala Val Ile Ala Met Lys Asn Gly Val Asn Trp Arg Asp Val 515 520 525 Ala Lys Trp Asn Gln Ile Asp Pro Glu Lys Thr Leu Phe Val Gly Thr 530 535 540 Ser Leu Tyr Leu Tyr Asp Ala Lys Pro Gln Glu Ala Glu Thr Thr Ala 545 550 555 560 Lys Ser Ala Ala Lys Pro Asp Val Tyr Val Val Gln Ala Asn Asp Ser 565 570 575 Leu Thr Gly Val Ala Asn Gln Phe Asn Leu Ser Val Lys Gln Leu Ala 580 585 590 Glu Tyr Asn Asp Leu Ser Val Thr Asp Gly Leu Phe Val Gly Gln Lys 595 600 605 Leu Gln Leu Lys Glu Pro Lys Gly Asn Arg Ala Ala Lys Val Glu Pro 610 615 620 Lys Ala Ile Gln Ala Ser Thr Arg Arg Ile Ala Thr Lys Ser Tyr Thr 625 630 635 640 Val Lys Arg Gly Glu Tyr Leu Lys Leu Ile Ala Asp Arg Tyr Ala Leu 645 650 655 Ser Asn Gln Glu Leu Ala Asp Leu Thr Pro Gly Leu Thr Ala Gly Ser 660 665 670 Asn Leu Ile Val Gly Gln Lys Ile Asn Val Pro Ala Lys Glu Ile Thr 675 680 685 Val Asp Glu Val Asp Asp Ser Lys Ala Ser Gly Lys Tyr Glu Lys Leu 690 695 700 Ala Ala Gly Pro Ser Tyr Lys Thr Glu Ser Tyr Lys Val Gln Arg Gly 705 710 715 720 Asp Thr Leu Ser Ser Ile Ala Thr Lys Ser Lys Ile Ser Leu Ala Glu 725 730 735 Leu Ala Glu Leu Asn Asn Leu Lys Ala Asn Ser His Val Gln Leu Gly 740 745 750 Gln Thr Leu Lys Val Pro Ala Gly Ala Ser Val Pro Asp Gln Tyr Val 755 760 765 Val Gln Ser Gly Asp Ser Leu Asn Ala Ile Ala Ala Lys Tyr Asn Leu 770 775 780 Gln Thr Ser Tyr Leu Ala Asp Leu Asn Gly Leu Ser Arg Thr Ala Gly 785 790 795 800 Leu Arg Ala Gly Gln Arg Leu Lys Leu Thr Gly Glu Val Glu Thr Thr 805 810 815 Ser Lys Val Ser Ala Lys Asn Thr Lys Glu Glu Thr Pro Glu Thr Tyr 820 825 830 Thr Val Lys Ser Gly Asp Ser Leu Gly Asn Ile Ala Asn Arg Tyr His 835 840 845 Leu Gln Leu Asp Tyr Leu Ala Ala Leu Asn Gly Leu Ser Arg Asn Ser 850 855 860 Asn Val Arg Val Gly Gln Arg Leu Lys Leu Thr Gly Asp Leu Pro Thr 865 870 875 880 Val Glu Thr Ala Lys Thr Asp Thr Ala Lys Ser Ser Pro Lys Ala Val 885 890 895 Val Ala Gly Lys Asn Thr Glu Lys Tyr Thr Val Lys Ala Gly Glu Ser 900 905 910 Leu Asn Ala Ile Ala Ser Arg Ala Gly Ile Ser Val Arg Glu Leu Ala 915 920 925 Glu Met Asn Ala Leu Lys Ala Asn Ala Asn Leu Gln Arg Gly Gln Asn 930 935 940 Ile Val Ile Pro Lys Thr Val Val Glu Tyr Lys Val Lys Arg Gly Asp 945 950 955 960 Thr Leu Ile Gly Leu Ala Ser Lys Tyr Gly Leu Glu Thr Thr Leu Leu 965 970 975 Ala Glu Leu Asn Asn Leu Thr Pro Ser Thr Gln Leu Arg Ile Gly Asp 980 985 990 Ile Ile Lys Val Pro Asn Leu 995 <210> SEQ ID NO 89 <211> LENGTH: 519 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 89 Met Arg Asn Ser Ala Met Gln Gln Leu Asn Pro Ser Glu Ile Ser Ala 1 5 10 15 Leu Ile Lys Gln Arg Ile Gly Asp Leu Asp Thr Ser Ala Thr Ala Lys 20 25 30 Asn Glu Gly Thr Ile Val Met Val Ser Asp Gly Ile Val Arg Ile His 35 40 45 Gly Leu Ala Asp Ala Met Tyr Gly Glu Met Ile Glu Phe Asp Gly Gly 50 55 60 Leu Phe Gly Met Ala Leu Asn Leu Glu Gln Asp Ser Val Gly Ala Val 65 70 75 80 Val Leu Gly Asn Tyr Leu Ser Leu Gln Glu Gly Gln Lys Ala Arg Cys 85 90 95 Thr Gly Arg Val Leu Glu Val Pro Val Gly Pro Glu Leu Leu Gly Arg 100 105 110 Val Val Asp Ala Leu Gly Asn Pro Ile Asp Gly Lys Gly Pro Ile Asp 115 120 125 Ala Lys Leu Thr Asp Ala Val Glu Lys Val Ala Pro Gly Val Ile Trp 130 135 140 Arg Gln Ser Val Asp Glu Pro Val Gln Thr Gly Tyr Lys Ser Val Asp 145 150 155 160 Thr Met Ile Pro Val Gly Arg Gly Gln Arg Glu Leu Ile Ile Gly Asp 165 170 175 Arg Gln Thr Gly Lys Thr Ala Met Ala Ile Asp Ala Ile Ile Ala Gln 180 185 190 Lys His Ser Gly Ile Lys Cys Val Tyr Val Ala Ile Gly Gln Lys Gln 195 200 205 Ser Thr Ile Ala Asn Val Val Arg Lys Leu Glu Glu Thr Gly Ala Met 210 215 220 Ala Tyr Thr Thr Val Val Ala Ala Ala Ala Ala Asp Pro Ala Ala Met 225 230 235 240 Gln Tyr Leu Ala Pro Tyr Ser Gly Cys Thr Met Gly Glu Tyr Phe Arg 245 250 255 Asp Arg Gly Glu Asp Ala Leu Ile Ile Tyr Asp Asp Leu Ser Lys Gln 260 265 270 Ala Val Ala Tyr Arg Gln Ile Ser Leu Leu Leu Arg Arg Pro Pro Gly 275 280 285 Arg Glu Ala Tyr Pro Gly Asp Val Phe Tyr Leu His Ser Arg Leu Leu 290 295 300 Glu Arg Ala Ser Arg Val Ser Ala Asp Tyr Val Glu Lys Phe Thr Asn 305 310 315 320 Gly Ala Val Thr Gly Gln Thr Gly Ser Leu Thr Ala Leu Pro Ile Ile 325 330 335 Glu Thr Gln Ala Gly Asp Val Ser Ala Phe Val Pro Thr Asn Val Ile 340 345 350 Ser Ile Thr Asp Gly Gln Ile Phe Leu Glu Thr Ser Leu Phe Asn Ala 355 360 365 Gly Ile Arg Pro Ala Val Asn Ala Gly Ile Ser Val Ser Arg Val Gly 370 375 380 Gly Ser Ala Gln Thr Lys Ile Ile Lys Lys Leu Ser Gly Gly Ile Arg 385 390 395 400 Thr Ala Leu Ala Gln Tyr Arg Glu Leu Ala Ala Phe Ala Gln Phe Ala 405 410 415 Ser Asp Leu Asp Glu Ala Thr Arg Lys Gln Leu Glu His Gly Gln Arg 420 425 430 Val Thr Glu Leu Met Lys Gln Lys Gln Tyr Ala Pro Tyr Ser Ile Ala 435 440 445 Asp Gln Ala Val Ser Val Tyr Ala Ser Asn Glu Gly Tyr Met Ala Asp 450 455 460 Val Glu Val Lys Lys Ile Val Asp Phe Asp Ala Ala Leu Ile Ser Tyr 465 470 475 480 Phe Arg Ser Glu Tyr Ala Pro Leu Met Lys Gln Ile Asp Glu Thr Gly 485 490 495 Asp Tyr Asn Lys Asp Ile Glu Ala Ala Ile Lys Ser Gly Ile Glu Ser 500 505 510 Phe Lys Ala Thr Gln Thr Tyr 515 <210> SEQ ID NO 90 <400> SEQUENCE: 90 000 <210> SEQ ID NO 91 <400> SEQUENCE: 91 000 <210> SEQ ID NO 92 <400> SEQUENCE: 92 000 <210> SEQ ID NO 93 <400> SEQUENCE: 93 000 <210> SEQ ID NO 94 <400> SEQUENCE: 94 000 <210> SEQ ID NO 95 <400> SEQUENCE: 95 000 <210> SEQ ID NO 96 <400> SEQUENCE: 96 000 <210> SEQ ID NO 97 <400> SEQUENCE: 97 000 <210> SEQ ID NO 98 <400> SEQUENCE: 98 000 <210> SEQ ID NO 99 <400> SEQUENCE: 99 000 <210> SEQ ID NO 100 <211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: primer forward <400> SEQUENCE: 100 gctaattggt gaaggtagtc 20 <210> SEQ ID NO 101 <211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: primer reverse <400> SEQUENCE: 101 gacgaatcgt ttgaatctgc 20

1 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 101 <210> SEQ ID NO 1 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(12) <223> OTHER INFORMATION: anti-A. baumannii immunogen <400> SEQUENCE: 1 Thr Ser Ser Asp Thr Phe Arg Ser Asp Gly Leu Ala 1 5 10 <210> SEQ ID NO 2 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(28) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 2 Thr Ser Arg Gly Ser Gln Phe Asp Gly Asn Gly Asp Arg Ile Ser Leu 1 5 10 15 Ser Pro Trp Gln Gly Ser Thr Met Asp Thr Asp Thr 20 25 <210> SEQ ID NO 3 <211> LENGTH: 41 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(41) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 3 Tyr Lys Lys Gln Asp Thr Asp Tyr Gly Pro Asp Tyr Ser Tyr Leu Pro 1 5 10 15 Thr Thr Ser Lys Ser Asn Asp Ala Thr Thr Pro Thr Tyr Lys Ala Ile 20 25 30 Lys Gly Leu Lys Leu Ser Asn Pro Leu 35 40 <210> SEQ ID NO 4 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(29) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 4 Arg Asn Glu Lys Ser Arg Phe Phe Pro Tyr Gly Leu Ser Asn Lys Ser 1 5 10 15 Val Thr Ser Val Asn Gln Ser Gln Ser Glu Ile Glu Val 20 25 <210> SEQ ID NO 5 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(36) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 5 Glu Lys Asp Lys Gln Phe Val Asp Ile Leu Ala Thr Gln Tyr Pro Tyr 1 5 10 15 Leu Val Tyr Thr Pro Thr Gly Gln Arg Lys Gly Tyr Gly Pro Asn Thr 20 25 30 Glu Ile Gln Asn 35 <210> SEQ ID NO 6 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(28) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 6 Ile Gln Ala Asp Thr Asp Ala Tyr Ile Pro Ser Arg Glu Thr Thr Met 1 5 10 15 Val Pro Ala Gly Ser Thr His Asp Asp Lys Pro Leu 20 25 <210> SEQ ID NO 7 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 7 Pro Asp Val Gln Arg Met Leu Arg Asp Val Ser Thr Tyr Thr Val Ser 1 5 10 15 Thr Ala Asn Leu Gln Pro Ile Thr Val Asn Ser 20 25 <210> SEQ ID NO 8 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(23) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 8 Asn Thr Ser Asp Lys Thr Val Gln Phe Asn Asn Arg Ala Ala Lys Val 1 5 10 15 Val Asp Thr Asp Gln Arg Val 20 <210> SEQ ID NO 9 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(22) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 9 Thr Arg Gly Gln Tyr Lys Asp Val Ala Asn Lys Trp His Glu Leu Asn 1 5 10 15 Ser Phe Thr Val Ala Pro 20 <210> SEQ ID NO 10 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(36) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 10 Ile Lys Gly Thr Asn Lys Ala Tyr Lys Asp Asp Arg Glu Leu Ala Ala 1 5 10 15 Phe Ala Thr Thr Gln Asp Glu Ala Phe Gln Asn Ala Val Lys Asn Asp 20 25 30 Ala Asn Ser Ala 35 <210> SEQ ID NO 11 <211> LENGTH: 33 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(33) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 11 Tyr Asn Val Trp Asn Arg Gln Tyr Arg Thr Val Phe Ala Gln Gln Ala 1 5 10 15 Ala Val Ser Asn Ala Asn Pro Leu Leu Ala Ile Pro Ala Glu Gly Arg 20 25 30 Thr <210> SEQ ID NO 12 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(28) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 12 Val Lys Gly Ala Asp Ser Leu Thr Asn Ala Phe Gly Asp Pro Ser Ala 1 5 10 15 Thr Ile Asn Asn Ile Arg Lys Arg Pro Thr Gln Glu 20 25 <210> SEQ ID NO 13 <211> LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(28) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 13 Ser Gly Lys Val Arg Gly Arg Ile Met Gly Tyr Glu Gln Thr Gly Asp 1 5 10 15 Ser Tyr Leu Asp Arg Tyr Ser Ala Glu Lys Asn Gly 20 25 <210> SEQ ID NO 14 <211> LENGTH: 11

<212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(11) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 14 Ser Gln Glu Gln Asn Lys Pro Asn Ala Asn Asn 1 5 10 <210> SEQ ID NO 15 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(15) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 15 Asn Pro Asn Pro Asp Trp Ala His Trp Asp Asn Glu Thr Gln Asn 1 5 10 15 <210> SEQ ID NO 16 <211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(36) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 16 Leu Asp Thr Lys His Asn Ser Arg Leu Leu Tyr Tyr Tyr Gly Tyr Pro 1 5 10 15 Lys Ala Asp Gly Ser Gly Val Ser Leu Thr Pro Trp Gly Gly Gln Glu 20 25 30 His Gln Glu Lys 35 <210> SEQ ID NO 17 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(50) <223> OTHER INFORMATION: Anti-A. Baumanii immunogen <400> SEQUENCE: 17 Val Arg Asn His Gln Gln Asp Lys Gln Ser Thr Gly Thr Ile Asn Asp 1 5 10 15 Ser Asn Val Ile Lys Ser Thr Thr Thr Asp Trp Ala Ser Trp Thr Pro 20 25 30 Gln Ser Ile Thr Trp Ser Asp Phe Thr Glu Ala Ala Asn Tyr Lys Gln 35 40 45 Asn Ile 50 <210> SEQ ID NO 18 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(20) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 18 Val Gln Ala Glu Ser Lys Gly Glu Ser Tyr Ser Ser Pro Met Ser Tyr 1 5 10 15 Ser Glu Ser Lys 20 <210> SEQ ID NO 19 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(21) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 19 Arg Pro Gln Thr Gly Ile Asp Lys Asp Thr Asn Gln Ala Leu Lys Pro 1 5 10 15 Ile Glu Gly Lys Ser 20 <210> SEQ ID NO 20 <211> LENGTH: 29 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(29) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 20 Thr Glu Gln Asn Asn Tyr Pro Leu Arg Asn Ser Asp Gly Asn Pro Leu 1 5 10 15 Asn Arg Lys Val Pro Thr Ser Asp Leu Glu Ser Gln Gly 20 25 <210> SEQ ID NO 21 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(20) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 21 Ala Gln Phe Ser Ile Lys Asp Thr Lys Asn Gly Gly Glu Ala Arg Thr 1 5 10 15 Tyr Asn Pro Asn 20 <210> SEQ ID NO 22 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(20) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 22 Gln Asp Gly Ile Lys Leu Tyr Asp Ser Asn Val Asn Gly Thr Ile Lys 1 5 10 15 Gln Asp Ala Tyr 20 <210> SEQ ID NO 23 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(20) <223> OTHER INFORMATION: Anti-A. Baumannii immunogen <400> SEQUENCE: 23 Asp Lys Lys Tyr Leu Asn Ser Phe Pro Asp Gly Gln Ala Phe Tyr Gly 1 5 10 15 Ala Pro Ala Asn 20 <210> SEQ ID NO 24 <211> LENGTH: 586 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Fusion protein <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(586) <223> OTHER INFORMATION: Fusion protein <400> SEQUENCE: 24 Val Lys Gly Ala Asp Ser Leu Thr Asn Ala Phe Gly Asp Pro Ser Ala 1 5 10 15 Thr Ile Asn Asn Ile Arg Lys Arg Pro Thr Gln Glu Ser Gln Glu Gln 20 25 30 Asn Lys Pro Asn Ala Asn Asn Asn Pro Asn Pro Asp Trp Ala His Trp 35 40 45 Asp Asn Glu Thr Gln Asn Leu Asp Thr Lys His Asn Ser Arg Leu Leu 50 55 60 Tyr Tyr Tyr Gly Tyr Pro Lys Ala Asp Gly Ser Gly Val Ser Leu Thr 65 70 75 80 Pro Trp Gly Gly Gln Glu His Gln Glu Lys Val Arg Asn His Gln Gln 85 90 95 Asp Lys Gln Ser Thr Gly Thr Ile Asn Asp Ser Asn Val Ile Lys Ser 100 105 110 Thr Thr Thr Asp Trp Ala Ser Trp Thr Pro Gln Ser Ile Thr Trp Ser 115 120 125 Asp Phe Thr Glu Ala Ala Asn Tyr Lys Gln Asn Ile Val Gln Ala Glu 130 135 140 Ser Lys Gly Glu Ser Tyr Ser Ser Pro Met Ser Tyr Ser Glu Ser Lys 145 150 155 160 Arg Pro Gln Thr Gly Ile Asp Lys Asp Thr Asn Gln Ala Leu Lys Pro 165 170 175 Ile Glu Gly Lys Ser Thr Glu Gln Asn Asn Tyr Pro Leu Arg Asn Ser 180 185 190 Asp Gly Asn Pro Leu Asn Arg Lys Val Pro Thr Ser Asp Leu Glu Ser 195 200 205 Gln Gly Ala Gln Phe Ser Ile Lys Asp Thr Lys Asn Gly Gly Glu Ala 210 215 220 Arg Thr Tyr Asn Pro Asn Gln Asp Gly Ile Lys Leu Tyr Asp Ser Asn 225 230 235 240 Val Asn Gly Thr Ile Lys Gln Asp Ala Tyr Asp Lys Lys Tyr Leu Asn 245 250 255 Ser Phe Pro Asp Gly Gln Ala Phe Tyr Gly Ala Pro Ala Asn Thr Ser 260 265 270 Ser Asp Thr Phe Arg Ser Asp Gly Leu Ala Thr Ser Arg Gly Ser Gln 275 280 285 Phe Asp Gly Asn Gly Asp Arg Ile Ser Leu Ser Pro Trp Gln Gly Ser 290 295 300

Thr Met Asp Thr Asp Thr Tyr Lys Asp Lys Gln Asp Thr Asp Tyr Gly 305 310 315 320 Pro Asp Tyr Ser Tyr Leu Pro Thr Thr Ser Lys Ser Asn Asp Ala Thr 325 330 335 Thr Pro Thr Tyr Lys Ala Ile Lys Gly Leu Lys Leu Ser Asn Pro Leu 340 345 350 Arg Asn Glu Lys Ser Arg Phe Phe Pro Tyr Gly Leu Ser Asn Lys Ser 355 360 365 Val Thr Ser Val Asn Gln Ser Gln Ser Glu Ile Glu Val Glu Lys Asp 370 375 380 Lys Gln Phe Val Asp Ile Leu Ala Thr Gln Tyr Pro Tyr Leu Val Tyr 385 390 395 400 Thr Pro Thr Gly Gln Arg Lys Gly Tyr Gly Pro Asn Thr Glu Ile Gln 405 410 415 Asn Ile Gln Ala Asp Thr Asp Ala Tyr Ile Pro Ser Arg Glu Thr Thr 420 425 430 Met Val Pro Ala Gly Ser Thr His Asp Asp Lys Pro Leu Pro Asp Val 435 440 445 Gln Arg Met Leu Arg Asp Val Ser Thr Tyr Thr Val Ser Thr Ala Asn 450 455 460 Leu Gln Pro Ile Thr Val Asn Ser Asn Thr Ser Asp Lys Thr Val Gln 465 470 475 480 Phe Asn Asn Arg Ala Ala Lys Val Val Asp Thr Asp Gln Arg Val Thr 485 490 495 Arg Gly Gln Tyr Lys Asp Val Ala Asn Lys Trp His Glu Leu Asn Ser 500 505 510 Phe Thr Val Ala Pro Ile Lys Gly Thr Asn Lys Ala Tyr Lys Asp Asp 515 520 525 Arg Glu Leu Ala Ala Phe Ala Thr Thr Gln Asp Glu Ala Phe Gln Asn 530 535 540 Ala Val Lys Asn Asp Ala Asn Ser Ala Tyr Asn Val Trp Asn Arg Gln 545 550 555 560 Tyr Arg Thr Val Phe Ala Gln Gln Ala Ala Val Ser Asn Ala Asn Pro 565 570 575 Leu Leu Ala Ile Pro Ala Glu Gly Arg Thr 580 585 <210> SEQ ID NO 25 <211> LENGTH: 615 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Fusion protein <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(615) <223> OTHER INFORMATION: Fusion protein <400> SEQUENCE: 25 Met Ser Gly Lys Val Arg Gly Arg Ile Met Gly Tyr Glu Gln Thr Gly 1 5 10 15 Asp Ser Tyr Leu Asp Arg Tyr Ser Ala Glu Lys Asn Gly Val Lys Gly 20 25 30 Ala Asp Ser Leu Thr Asn Ala Phe Gly Asp Pro Ser Ala Thr Ile Asn 35 40 45 Asn Ile Arg Lys Arg Pro Thr Gln Glu Ser Gln Glu Gln Asn Lys Pro 50 55 60 Asn Ala Asn Asn Asn Pro Asn Pro Asp Trp Ala His Trp Asp Asn Glu 65 70 75 80 Thr Gln Asn Leu Asp Thr Lys His Asn Ser Arg Leu Leu Tyr Tyr Tyr 85 90 95 Gly Tyr Pro Lys Ala Asp Gly Ser Gly Val Ser Leu Thr Pro Trp Gly 100 105 110 Gly Gln Glu His Gln Glu Lys Val Arg Asn His Gln Gln Asp Lys Gln 115 120 125 Ser Thr Gly Thr Ile Asn Asp Ser Asn Val Ile Lys Ser Thr Thr Thr 130 135 140 Asp Trp Ala Ser Trp Thr Pro Gln Ser Ile Thr Trp Ser Asp Phe Thr 145 150 155 160 Glu Ala Ala Asn Tyr Lys Gln Asn Ile Val Gln Ala Glu Ser Lys Gly 165 170 175 Glu Ser Tyr Ser Ser Pro Met Ser Tyr Ser Glu Ser Lys Arg Pro Gln 180 185 190 Thr Gly Ile Asp Lys Asp Thr Asn Gln Ala Leu Lys Pro Ile Glu Gly 195 200 205 Lys Ser Thr Glu Gln Asn Asn Tyr Pro Leu Arg Asn Ser Asp Gly Asn 210 215 220 Pro Leu Asn Arg Lys Val Pro Thr Ser Asp Leu Glu Ser Gln Gly Ala 225 230 235 240 Gln Phe Ser Ile Lys Asp Thr Lys Asn Gly Gly Glu Ala Arg Thr Tyr 245 250 255 Asn Pro Asn Gln Asp Gly Ile Lys Leu Tyr Asp Ser Asn Val Asn Gly 260 265 270 Thr Ile Lys Gln Asp Ala Tyr Asp Lys Lys Tyr Leu Asn Ser Phe Pro 275 280 285 Asp Gly Gln Ala Phe Tyr Gly Ala Pro Ala Asn Thr Ser Ser Asp Thr 290 295 300 Phe Arg Ser Asp Gly Leu Ala Thr Ser Arg Gly Ser Gln Phe Asp Gly 305 310 315 320 Asn Gly Asp Arg Ile Ser Leu Ser Pro Trp Gln Gly Ser Thr Met Asp 325 330 335 Thr Asp Thr Tyr Lys Asp Lys Gln Asp Thr Asp Tyr Gly Pro Asp Tyr 340 345 350 Ser Tyr Leu Pro Thr Thr Ser Lys Ser Asn Asp Ala Thr Thr Pro Thr 355 360 365 Tyr Lys Ala Ile Lys Gly Leu Lys Leu Ser Asn Pro Leu Arg Asn Glu 370 375 380 Lys Ser Arg Phe Phe Pro Tyr Gly Leu Ser Asn Lys Ser Val Thr Ser 385 390 395 400 Val Asn Gln Ser Gln Ser Glu Ile Glu Val Glu Lys Asp Lys Gln Phe 405 410 415 Val Asp Ile Leu Ala Thr Gln Tyr Pro Tyr Leu Val Tyr Thr Pro Thr 420 425 430 Gly Gln Arg Lys Gly Tyr Gly Pro Asn Thr Glu Ile Gln Asn Ile Gln 435 440 445 Ala Asp Thr Asp Ala Tyr Ile Pro Ser Arg Glu Thr Thr Met Val Pro 450 455 460 Ala Gly Ser Thr His Asp Asp Lys Pro Leu Pro Asp Val Gln Arg Met 465 470 475 480 Leu Arg Asp Val Ser Thr Tyr Thr Val Ser Thr Ala Asn Leu Gln Pro 485 490 495 Ile Thr Val Asn Ser Asn Thr Ser Asp Lys Thr Val Gln Phe Asn Asn 500 505 510 Arg Ala Ala Lys Val Val Asp Thr Asp Gln Arg Val Thr Arg Gly Gln 515 520 525 Tyr Lys Asp Val Ala Asn Lys Trp His Glu Leu Asn Ser Phe Thr Val 530 535 540 Ala Pro Ile Lys Gly Thr Asn Lys Ala Tyr Lys Asp Asp Arg Glu Leu 545 550 555 560 Ala Ala Phe Ala Thr Thr Gln Asp Glu Ala Phe Gln Asn Ala Val Lys 565 570 575 Asn Asp Ala Asn Ser Ala Tyr Asn Val Trp Asn Arg Gln Tyr Arg Thr 580 585 590 Val Phe Ala Gln Gln Ala Ala Val Ser Asn Ala Asn Pro Leu Leu Ala 595 600 605 Ile Pro Ala Glu Gly Arg Thr 610 615 <210> SEQ ID NO 26 <211> LENGTH: 1650 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Polynucleotide coding for the fusion protein <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (1)..(1650) <223> OTHER INFORMATION: Polynucleotide coding for fusion protein <400> SEQUENCE: 26 atgtctggta aagttcgtgg tcgtatcatg ggttacgaac agaccggtga ctcttacctg 60 gaccgttact ctgctgaaaa aaacggtgtt aaaggtgctg actctctgac caacgctttc 120 ggtgacccgt ctgctaccat caacaacatc cgtaaacgtc cgacccagga atctcaggaa 180 cagaacaaac cgaacgctaa caacaacccg aacccggact gggctcactg ggacaacgaa 240 acccagaacc tggacaccaa acacaactct cgtctgctgt actactacgg ttacccgaaa 300 gctgacggtt ctggtgtttc tctgaccccg tggggtggtc aggaacacca ggaaaaagtt 360 cgtaaccacc agcaggacaa acagtctacc ggtaccatca acgactctaa cgttatcaaa 420 tctaccacca ccgactgggc ttcttggacc ccgcagtcta tcacctggtc tgacttcacc 480 gaagctgcta actacaaaca gaacatcgtt caggctgaat ctaaaggtga atcttactct 540 tctccgatgt cttactctga atctaaacgt ccgcagaccg gtatcgacaa agacaccaac 600 caggctctga aaccgatcga aggtaaatct accgaacaga acaactaccc gctgcgtaac 660 tctgacggta acccgctgaa ccgtaaagtt ccgacctctg acctggaatc tcagggtgct 720 cagttctcta tcaaagacac caaaaacggt ggtgaagctc gtacctacaa cccgaaccag 780 gacggtatca aactgtacga ctctaacgtt aacggtacca tcaaacagga cgcttacgac 840 aaaaaatacc tgaactcttt cccggacggt caggctttct acggtgctcc ggctaacacc 900 tcttctgaca ccttccgttc tgacggtctg gctacctctc gtggttctca gttcgacggt 960 aacggtgacc gtatctctct gtctccgtgg cagggttcta ccatggacac cgacacctac 1020 aaagacaaac aggacaccga ctacggtccg gactactctt acctgccgac cacctctaaa 1080 tctaacgacg ctaccacccc gacctacaaa gctatcaaag gtctgaaact gtctaacccg 1140 ctgcgtaacg aaaaatctcg tttcttcccg tacggtctgt ctaacaaatc tgttacctct 1200 gttaaccagt ctcagtctga aatcgaagtt gaaaaagaca aacagttcgt tgacatcctg 1260 gctacccagt acccgtacct ggtttacacc ccgaccggtc agcgtaaagg ttacggtccg 1320 aacaccgaaa tccagaacat ccaggctgac accgacgctt acatcccgtc tcgtgaaacc 1380 accatggttc cggctggttc tacccacgac gacaaaccgc tgccggacgt tcagcgtatg 1440 ctgcgtgacg tttctaccta caccgtttct accgctaacc tgcagccgat caccgttaac 1500 tctaacacct ctgacaaaac cgttcagttc aacaaccgtg ctgctaaagt tgttgacacc 1560

gaccagcgtg ttacccgtgg tcagtacaaa gacgttgcta acaaatggca cgaactgaac 1620 tctttcaccg ttgctccgat caaaggtacc 1650 <210> SEQ ID NO 27 <211> LENGTH: 746 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(746) <223> OTHER INFORMATION: Amino acid sequence of putative ferric siderophore receptor protein <400> SEQUENCE: 27 Met Thr Pro Cys Cys Leu Ala Ile Ser Ala Ile Phe Ala Gln Gln Ala 1 5 10 15 Tyr Ala Glu Thr Val Thr Gln Thr Ala Glu Val Ser Glu Asn Ala Thr 20 25 30 Gln Lys Pro Val Ala Gln Leu Gln Lys Ile Val Val Thr Ala Thr Arg 35 40 45 Thr Pro Lys Asn Ile Ala Glu Ile Ala Gly Thr Val Gln Ser Ile Asp 50 55 60 Gln Lys Gln Ile Ile Gln Gln Ala Thr Ala Gly Arg Lys Val Ala Asp 65 70 75 80 Ile Leu Ala Gln Leu Val Pro Ser Leu Ala Ser Ser Ser Gly Thr Thr 85 90 95 Ser Asn Tyr Gly Gln Thr Met Arg Gly Arg Asn Val Leu Val Met Ile 100 105 110 Asp Gly Val Ser Gln Thr Gly Ser Arg Asp Val Ser Arg Gln Leu Asn 115 120 125 Ser Ile Ser Pro Gly Met Ile Glu Arg Ile Glu Val Ile Ser Gly Ala 130 135 140 Thr Ser Ile Tyr Gly Ser Gly Ala Thr Gly Gly Ile Ile Asn Ile Ile 145 150 155 160 Thr Lys Arg Ala Asp Thr Ser Lys Pro Leu Ser Phe Glu Thr Lys Val 165 170 175 Gly Ile Thr Ser Ser Asp Thr Phe Arg Ser Asp Gly Leu Ala Tyr Glu 180 185 190 Val Gly Gln Ser Val Ser Phe Asn Lys Gly Asn Ile Asp Gly Phe Leu 195 200 205 Gly Ala Asn Phe Thr Ser Arg Gly Ser Gln Phe Asp Gly Asn Gly Asp 210 215 220 Arg Ile Ser Leu Ser Pro Trp Gln Gly Ser Thr Met Asp Thr Asp Thr 225 230 235 240 Ile Asp Val Asn Gly Arg Leu Asn Phe Asn Leu Asn Asp Thr Gln Thr 245 250 255 Leu Ser Phe Gly Ala Gln Tyr Tyr Lys Asp Lys Gln Asp Thr Asp Tyr 260 265 270 Gly Pro Asp Tyr Ser Tyr Leu Pro Thr Thr Ser Lys Ser Asn Asp Ala 275 280 285 Thr Thr Pro Thr Tyr Lys Ala Ile Lys Gly Leu Lys Leu Ser Asn Pro 290 295 300 Leu Phe Thr Glu Arg Tyr Ala Val Asn Ser Gln Tyr Gln Asn Gln Asp 305 310 315 320 Phe Leu Gly Gln Ile Leu Asn Val Glu Ala Tyr Tyr Arg Asn Glu Lys 325 330 335 Ser Arg Phe Phe Pro Tyr Gly Leu Ser Asn Lys Ser Val Thr Ser Val 340 345 350 Asn Gln Ser Gln Ser Glu Ile Glu Val Ala Gly Leu Arg Ser Thr Met 355 360 365 Gln Thr Asp Leu Asn Ile Ala Asn Arg Asp Met Lys Ile Thr Tyr Gly 370 375 380 Leu Asp Tyr Asp Trp Glu Lys Asp Lys Gln Phe Val Asp Ile Leu Ala 385 390 395 400 Thr Gln Tyr Pro Tyr Leu Val Tyr Thr Pro Thr Gly Gln Arg Lys Gly 405 410 415 Tyr Gly Pro Asn Thr Glu Ile Gln Asn Ile Gly Ala Phe Val Gln Ser 420 425 430 Asp Tyr Ala Val Thr Asp Lys Leu Asn Leu Gln Ala Gly Ile Arg Tyr 435 440 445 Gln Tyr Ile Gln Ala Asp Thr Asp Ala Tyr Ile Pro Ser Arg Glu Thr 450 455 460 Thr Met Val Pro Ala Gly Ser Thr His Asp Asp Lys Pro Leu Phe Asn 465 470 475 480 Leu Gly Ala Val Tyr Lys Leu Thr Asp Ala Gln Gln Val Tyr Ala Asn 485 490 495 Phe Ser Gln Gly Phe Ser Phe Pro Asp Val Gln Arg Met Leu Arg Asp 500 505 510 Val Ser Thr Tyr Thr Val Ser Thr Ala Asn Leu Gln Pro Ile Thr Val 515 520 525 Asn Ser Tyr Glu Leu Gly Trp Arg Leu Asn Gln Asp Asp Gly Leu Asn 530 535 540 Leu Gly Leu Thr Gly Phe Tyr Asn Thr Ser Asp Lys Thr Val Gln Phe 545 550 555 560 Asn Asn Arg Ala Ala Lys Val Val Asp Thr Asp Gln Arg Val Tyr Gly 565 570 575 Ala Glu Ala Thr Ile Ser Tyr Pro Phe Met Glu Asn Tyr Lys Val Gly 580 585 590 Gly Thr Leu Gly Tyr Thr Arg Gly Gln Tyr Lys Asp Val Ala Asn Lys 595 600 605 Trp His Glu Leu Asn Ser Phe Thr Val Ala Pro Val Lys Gly Thr Leu 610 615 620 Phe Ala Glu Trp Asp Asn Asn Glu Gly Tyr Gly Val Arg Val Gln Met 625 630 635 640 Gln Ala Ile Lys Gly Thr Asn Lys Ala Tyr Lys Asp Asp Arg Glu Leu 645 650 655 Ala Ala Phe Ala Thr Thr Gln Asp Glu Ala Phe Gln Asn Ala Val Lys 660 665 670 Asn Asp Ala Asn Ser Ala Ala Gln Ile Lys Gly Tyr Thr Thr Met Asp 675 680 685 Val Leu Ala His Phe Pro Ala Trp Lys Gly Arg Val Asp Phe Gly Val 690 695 700 Tyr Asn Val Trp Asn Arg Gln Tyr Arg Thr Val Phe Ala Gln Gln Ala 705 710 715 720 Ala Val Ser Asn Ala Asn Pro Leu Leu Ala Ile Pro Ala Glu Gly Arg 725 730 735 Thr Tyr Gly Leu Ser Tyr Thr Phe Asn Tyr 740 745 <210> SEQ ID NO 28 <211> LENGTH: 679 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(679) <223> OTHER INFORMATION: Amino acid sequence of putative ferric hydroxamate siderophore receptor <400> SEQUENCE: 28 Met Gln Thr Ile Gln Val Lys Ala Ser Asp Ala Glu Gln Ser Ser Glu 1 5 10 15 Gln Thr Lys Ala Tyr Asn Val Lys Asn Ser Ser Ser Ala Thr Lys Leu 20 25 30 Asn Ile Glu Ala Lys Glu Thr Pro Gln Thr Ile Asn Val Val Thr Arg 35 40 45 Gln Gln Ile Glu Asp Phe Gly Leu Thr Ser Thr Arg Asp Val Leu Arg 50 55 60 Asn Thr Pro Gly Val Thr Val Ser Asn Gln Glu Thr Glu Arg Thr Thr 65 70 75 80 Tyr Met Ala Arg Gly Phe Glu Ile Ser Asn Ile Leu Thr Asp Gly Val 85 90 95 Gly Phe Pro Leu Ser Gly Tyr Asn Tyr Asn Asn Thr Asn Pro Asp Thr 100 105 110 Tyr Phe Tyr Asp Arg Val Glu Val Val Lys Gly Ala Asp Ser Leu Thr 115 120 125 Asn Ala Phe Gly Asp Pro Ser Ala Thr Ile Asn Asn Ile Arg Lys Arg 130 135 140 Pro Thr Gln Glu Phe Gln Ala Ser Asp Gly Val Ser Tyr Gly Ser Trp 145 150 155 160 Asp Thr Gln Arg Tyr Glu Ala Asp Val Ser Gly Ser Ile Leu Pro Ser 165 170 175 Gly Lys Val Arg Gly Arg Ile Met Gly Tyr Glu Gln Thr Gly Asp Ser 180 185 190 Tyr Leu Asp Arg Tyr Ser Ala Glu Lys Asn Gly Phe Ala Gly Ile Val 195 200 205 Glu Ala Asp Leu Thr Asp Ser Thr Leu Leu Thr Ala Gly Tyr Ser Gln 210 215 220 Glu Gln Asn Lys Pro Asn Ala Asn Asn Trp Gly Ala Leu Pro Leu Leu 225 230 235 240 Asp Ala Asn Gly Lys Gln Ile Ser Tyr Asp Arg Ser Tyr Asn Pro Asn 245 250 255 Pro Asp Trp Ala His Trp Asp Asn Glu Thr Gln Asn Ala Phe Val Glu 260 265 270 Leu Lys Gln Lys Leu Asn Asp Gln Trp Asn Ala Lys Leu Thr Tyr Asn 275 280 285 Tyr Leu Asp Thr Lys His Asn Ser Arg Leu Leu Tyr Tyr Tyr Gly Tyr 290 295 300 Pro Lys Ala Asp Gly Ser Gly Val Ser Leu Thr Pro Trp Gly Gly Gln 305 310 315 320 Glu His Gln Glu Lys His Ala Val Asp Phe Asn Leu Glu Gly Thr Tyr 325 330 335 Lys Leu Phe Asn Arg Glu His Glu Ala Thr Leu Gly Tyr Ser Tyr Val 340 345 350 Arg Asn His Gln Gln Asp Lys Gln Ser Thr Gly Thr Ile Asn Asp Ser 355 360 365 Asn Val Ile Lys Ser Thr Thr Thr Asp Trp Ala Ser Trp Thr Pro Gln 370 375 380 Ser Ile Thr Trp Ser Ala Phe Thr Glu Ala Ala Asn Tyr Lys Gln Asn 385 390 395 400 Ile Asn Ser Ile Tyr Ala Ala Thr Arg Leu His Leu Asn Glu Asp Leu 405 410 415 Lys Leu Leu Leu Gly Val Asn Tyr Val Gln Ala Glu Ser Lys Gly Glu

420 425 430 Ser Tyr Ser Ser Pro Met Ser Tyr Ser Glu Ser Lys Val Ser Pro Tyr 435 440 445 Val Gly Leu Thr Tyr Asn Phe Thr Pro Glu Tyr Thr Gly Tyr Met Ser 450 455 460 Tyr Thr Ser Ile Phe Arg Pro Gln Thr Gly Ile Asp Lys Asp Thr Asn 465 470 475 480 Gln Ala Leu Lys Pro Ile Glu Gly Lys Ser Tyr Glu Met Gly Val Lys 485 490 495 Ser Ser Trp Leu Asp Asp Arg Leu Thr Gly Thr Leu Ser Val Phe Lys 500 505 510 Thr Glu Gln Asn Asn Tyr Pro Leu Arg Asn Ser Asp Gly Asn Pro Leu 515 520 525 Asn Arg Lys Val Pro Thr Ser Asp Leu Glu Ser Gln Gly Val Glu Val 530 535 540 Gly Leu Ser Gly Gln Ile Thr Asp Asn Val Asn Leu Ser Leu Gly Tyr 545 550 555 560 Ala Gln Phe Ser Ile Lys Asp Thr Lys Asn Gly Gly Glu Ala Arg Ile 565 570 575 Tyr Asn Pro Asn Gln Thr Leu Asn Leu Leu Thr Thr Tyr Thr Pro Pro 580 585 590 Val Leu Pro Lys Leu Lys Val Gly Ala Gly Leu Gln Trp Gln Asp Gly 595 600 605 Ile Lys Leu Tyr Asp Ser Asn Val Asn Gly Thr Ile Lys Gln Asp Ala 610 615 620 Tyr Ala Leu Val Asn Leu Met Ala Ser Tyr Glu Val Asn Asp His Ile 625 630 635 640 Thr Leu Gln Ala Asn Gly Asn Asn Ile Phe Asp Lys Lys Tyr Leu Asn 645 650 655 Ser Phe Pro Asp Gly Gln Ala Phe Tyr Gly Ala Pro Ala Asn Tyr Thr 660 665 670 Val Ala Val Lys Phe Lys Tyr 675 <210> SEQ ID NO 29 <211> LENGTH: 829 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 29 Met Pro Leu Ala Leu Val Ser Ala Met Ala Ala Val Gln Gln Ala Tyr 1 5 10 15 Ala Ala Asp Asp Phe Val Val Arg Asp Ile Arg Val Asn Gly Leu Val 20 25 30 Arg Leu Thr Pro Ala Asn Val Tyr Thr Met Leu Pro Ile Asn Ser Gly 35 40 45 Asp Arg Val Asn Glu Pro Met Ile Ala Glu Ala Ile Arg Thr Leu Tyr 50 55 60 Ala Thr Gly Leu Phe Asp Asp Ile Lys Ala Ser Lys Glu Asn Asp Thr 65 70 75 80 Leu Val Phe Asn Val Ile Glu Arg Pro Ile Ile Ser Lys Leu Glu Phe 85 90 95 Lys Gly Asn Lys Leu Ile Pro Lys Glu Ala Leu Glu Gln Gly Leu Lys 100 105 110 Lys Met Gly Ile Ala Glu Gly Glu Val Phe Lys Lys Ser Ala Leu Gln 115 120 125 Thr Ile Glu Thr Glu Leu Glu Gln Gln Tyr Thr Gln Gln Gly Arg Tyr 130 135 140 Asp Ala Asp Val Thr Val Asp Thr Val Ala Arg Pro Asn Asn Arg Val 145 150 155 160 Glu Leu Lys Ile Asn Phe Asn Glu Gly Thr Pro Ala Lys Val Phe Asp 165 170 175 Ile Asn Val Ile Gly Asn Thr Val Phe Lys Asp Ser Glu Ile Lys Gln 180 185 190 Ala Phe Ala Val Lys Glu Ser Gly Trp Ala Ser Val Val Thr Arg Asn 195 200 205 Asp Arg Tyr Ala Arg Glu Lys Met Ala Ala Ser Leu Glu Ala Leu Arg 210 215 220 Ala Met Tyr Leu Asn Lys Gly Tyr Ile Asn Phe Asn Ile Asn Asn Ser 225 230 235 240 Gln Leu Asn Ile Ser Glu Asp Lys Lys His Ile Phe Ile Glu Val Ala 245 250 255 Val Asp Glu Gly Ser Gln Phe Lys Phe Gly Gln Thr Lys Phe Leu Gly 260 265 270 Asp Ala Leu Tyr Lys Pro Glu Glu Leu Gln Ala Leu Lys Ile Tyr Lys 275 280 285 Asp Gly Asp Thr Tyr Ser Gln Glu Lys Val Asn Ala Val Lys Gln Leu 290 295 300 Leu Leu Arg Lys Tyr Gly Asn Ala Gly Tyr Tyr Phe Ala Asp Val Asn 305 310 315 320 Ile Val Pro Gln Ile Asn Asn Glu Thr Gly Val Val Asp Leu Asn Tyr 325 330 335 Tyr Val Asn Pro Gly Gln Gln Val Thr Val Arg Arg Ile Asn Phe Thr 340 345 350 Gly Asn Ser Lys Thr Ser Asp Glu Val Leu Arg Arg Glu Met Arg Gln 355 360 365 Met Glu Gly Ala Leu Ala Ser Asn Glu Lys Ile Asp Leu Ser Lys Val 370 375 380 Arg Leu Glu Arg Thr Gly Phe Phe Lys Thr Val Asp Ile Lys Pro Ala 385 390 395 400 Arg Ile Pro Asn Ser Pro Asp Gln Val Asp Leu Asn Val Asn Val Glu 405 410 415 Glu Gln His Ser Gly Thr Thr Thr Leu Ala Val Gly Tyr Ser Gln Ser 420 425 430 Gly Gly Ile Thr Phe Gln Ala Gly Leu Ser Gln Thr Asn Phe Met Gly 435 440 445 Thr Gly Asn Arg Val Ala Ile Asp Leu Ser Arg Ser Glu Thr Gln Asp 450 455 460 Tyr Tyr Asn Leu Ser Val Thr Asp Pro Tyr Phe Thr Ile Asp Gly Val 465 470 475 480 Ser Arg Gly Tyr Asn Val Tyr Tyr Arg Lys Thr Lys Leu Asn Asp Asp 485 490 495 Tyr Asn Val Asn Asn Tyr Val Thr Asp Ser Phe Gly Gly Ser Leu Ser 500 505 510 Phe Gly Tyr Pro Ile Asp Glu Asn Gln Ser Leu Ser Ala Ser Val Gly 515 520 525 Val Asp Asn Thr Lys Val Thr Thr Gly Ala Phe Val Ser Thr Tyr Val 530 535 540 Arg Asp Tyr Leu Leu Ala Asn Gly Gly Lys Thr Thr Ser Thr Asn Thr 545 550 555 560 Tyr Cys Leu Val Asp Leu Val Gln Asp Pro Gln Thr Gly Leu Tyr Lys 565 570 575 Cys Pro Glu Gly Gln Thr Ser Gln Pro Tyr Gly Asn Ala Phe Glu Gly 580 585 590 Glu Phe Phe Thr Tyr Asn Leu Asn Leu Gly Trp Ser Tyr Asn Thr Leu 595 600 605 Asn Arg Pro Ile Phe Pro Thr Ser Gly Met Ser His Arg Val Gly Leu 610 615 620 Glu Ile Gly Leu Pro Gly Ser Asp Val Asp Tyr Gln Lys Val Thr Tyr 625 630 635 640 Asp Thr Gln Ala Phe Phe Pro Ile Gly Ser Thr Gly Phe Val Leu Arg 645 650 655 Gly Tyr Gly Lys Leu Gly Tyr Gly Asn Asp Leu Pro Phe Tyr Lys Asn 660 665 670 Phe Tyr Ala Gly Gly Tyr Gly Ser Val Arg Gly Tyr Asp Asn Ser Thr 675 680 685 Leu Gly Pro Lys Tyr Ala Ser Val Asn Leu Gln Glu Glu Lys Lys Asn 690 695 700 Asp Ser Ser Pro Glu Glu Val Gly Gly Asn Ala Leu Val Gln Phe Gly 705 710 715 720 Thr Glu Leu Val Leu Pro Met Pro Phe Lys Gly Asp Trp Thr Arg Gln 725 730 735 Val Arg Pro Val Leu Phe Ala Glu Gly Gly Gln Val Phe Asp Thr Lys 740 745 750 Cys Asp Val Arg Ser Tyr Ser Met Ile Met Asn Gly Gln Gln Ile Ser 755 760 765 Asp Ala Lys Lys Tyr Cys Glu Asp Asn Tyr Gly Phe Asp Leu Gly Asn 770 775 780 Leu Arg Tyr Ser Val Gly Val Gly Val Thr Trp Ile Thr Met Ile Gly 785 790 795 800 Pro Leu Ser Leu Ser Tyr Ala Phe Pro Leu Asn Asp Lys Pro Gly Asp 805 810 815 Glu Thr Lys Glu Ile Gln Phe Glu Ile Gly Arg Thr Phe 820 825 <210> SEQ ID NO 30 <211> LENGTH: 458 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 30 Met Arg Gly Pro Glu Pro Val Val Lys Thr Asp Ile Pro Gln Ser Tyr 1 5 10 15 Ala Tyr Asn Ser Ala Ser Gly Thr Ser Ile Ala Glu Gln Gly Tyr Lys 20 25 30 Gln Phe Phe Ala Asp Pro Arg Leu Leu Glu Val Ile Asp Leu Ala Leu 35 40 45 Ala Asn Asn Arg Asp Leu Arg Thr Ala Thr Leu Asn Ile Glu Arg Ala 50 55 60 Gln Gln Gln Tyr Gln Ile Thr Gln Asn Asn Gln Leu Pro Thr Ile Gly 65 70 75 80 Ala Ser Gly Ser Ala Ile Arg Gln Val Ser Gln Ser Arg Asp Pro Asn 85 90 95 Asn Pro Tyr Ser Thr Tyr Gln Val Gly Leu Gly Val Thr Ala Tyr Glu 100 105 110 Leu Asp Phe Trp Gly Arg Val Arg Ser Leu Lys Asp Ala Ala Leu Asp 115 120 125 Ser Tyr Leu Ala Thr Gln Ser Ala Arg Asp Ser Thr Gln Ile Ser Leu 130 135 140 Ile Ser Gln Val Ala Gln Ala Trp Leu Asn Tyr Ser Phe Ala Thr Ala 145 150 155 160

Asn Leu Arg Leu Ala Glu Gln Thr Leu Lys Ala Gln Leu Asp Ser Tyr 165 170 175 Asn Leu Asn Lys Lys Arg Phe Asp Val Gly Ile Asp Ser Glu Val Pro 180 185 190 Leu Arg Gln Ala Gln Ile Ser Val Glu Thr Ala Arg Asn Asp Val Ala 195 200 205 Asn Tyr Lys Thr Gln Ile Ala Gln Ala Gln Asn Leu Leu Asn Leu Leu 210 215 220 Val Gly Gln Pro Val Pro Gln Asn Leu Leu Pro Thr Gln Pro Val Lys 225 230 235 240 Arg Ile Ala Gln Gln Asn Val Phe Thr Ala Gly Leu Pro Ser Asp Leu 245 250 255 Leu Asn Asn Arg Pro Asp Val Lys Ala Ala Glu Tyr Asn Leu Ser Ala 260 265 270 Ala Gly Ala Asn Ile Gly Ala Ala Lys Ala Arg Leu Phe Pro Thr Ile 275 280 285 Ser Leu Thr Gly Ser Ala Gly Tyr Ala Ser Thr Asp Leu Ser Asp Leu 290 295 300 Phe Lys Ser Gly Gly Phe Val Trp Ser Val Gly Pro Ser Leu Asp Leu 305 310 315 320 Pro Ile Phe Asp Trp Gly Thr Arg Arg Ala Asn Val Lys Ile Ser Glu 325 330 335 Thr Asp Gln Lys Ile Ala Leu Ser Asp Tyr Glu Lys Ser Val Gln Ser 340 345 350 Ala Phe Arg Glu Val Asn Asp Ala Leu Ala Thr Arg Ala Asn Ile Gly 355 360 365 Glu Arg Leu Thr Ala Gln Gln Arg Leu Val Glu Ala Thr Asn Arg Asn 370 375 380 Tyr Thr Leu Ser Asn Ala Arg Phe Arg Ala Gly Ile Asp Ser Tyr Leu 385 390 395 400 Thr Val Leu Asp Ala Gln Arg Ser Ser Tyr Ala Ala Glu Gln Gly Leu 405 410 415 Leu Leu Leu Gln Gln Ala Asn Leu Asn Asn Gln Ile Glu Leu Tyr Lys 420 425 430 Thr Leu Gly Gly Gly Leu Lys Ala Asn Thr Ser Asp Thr Val Val His 435 440 445 Gln Pro Ser Ser Ala Glu Leu Lys Lys Gln 450 455 <210> SEQ ID NO 31 <211> LENGTH: 412 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 31 Met Met Ser Gly Ala Asn Ala Ala Thr Ser Asp Lys Glu Glu Ile Arg 1 5 10 15 Lys Leu Arg Gln Glu Val Glu Ala Leu Lys Ala Leu Val Gln Glu Gln 20 25 30 Arg Gln Val Gln Gln Gln Gln Gln Gln Val Gln Gln Gln Gln Gln Val 35 40 45 Gln Leu Ala Glu Val Lys Ala Gln Pro Gln Pro Val Ala Ala Pro Val 50 55 60 Ser Pro Leu Ala Gly Phe Lys Ser Lys Ala Gly Ala Asp Val Asn Leu 65 70 75 80 Tyr Gly Phe Val Arg Gly Asp Ala Asn Tyr Ile Ile Glu Gly Ala Asp 85 90 95 Asn Asp Phe Gly Asp Val Ser Lys Ser Asp Gly Lys Thr His Asp Lys 100 105 110 Leu Arg Ala Thr Ala Lys Thr Thr Arg Leu Gly Leu Asp Phe Asn Thr 115 120 125 Pro Val Gly Asp Asp Lys Val Gly Gly Lys Ile Glu Val Asp Phe Ala 130 135 140 Gly Ser Thr Thr Asp Ser Asn Gly Ser Leu Arg Ile Arg His Ala Tyr 145 150 155 160 Leu Thr Tyr Asn Asn Trp Leu Phe Gly Gln Thr Thr Ser Asn Phe Leu 165 170 175 Ser Asn His Ala Pro Glu Met Ile Asp Phe Ser Thr Asn Ile Gly Gly 180 185 190 Gly Thr Lys Arg Val Pro Gln Val Arg Tyr Asn Tyr Lys Leu Gly Pro 195 200 205 Thr Thr Gln Leu Phe Val Ser Ala Glu Lys Gly Asp Ser Thr Thr Ser 210 215 220 Val Thr Gly Asp Ser Ile Lys Tyr Ser Leu Pro Ala Leu Thr Ala Lys 225 230 235 240 Ile Thr Gln Gly Tyr Ala Glu Gly Arg Gly Ser Ala Ser Ala Arg Val 245 250 255 Leu Val Glu Asn Tyr Lys Ser Gln Leu Ala Asp Asp Asp Lys Thr Gly 260 265 270 Trp Gly Val Ala Val Gly Thr Asp Phe Lys Val Ser Asp Pro Leu Lys 275 280 285 Leu Phe Ala Asp Ala Ser Tyr Val Val Gly Asp Asn Ser Tyr Leu Tyr 290 295 300 Gly Ser Asn Ser Pro Tyr Ala Val Asp Gly Asn Ser Ile Glu Gln Asn 305 310 315 320 Glu Phe Val Ala Val Gln Val Gly Gly Thr Tyr Lys Ile Leu Pro Asn 325 330 335 Leu Arg Ser Thr Leu Ala Tyr Gly Ala Gln Phe Ser Asp Asp Gly Thr 340 345 350 Asp Tyr Ala Arg Leu Asn Ala Ser Ala Asn Glu Lys Val Gln Gln Ala 355 360 365 Trp Ile Asn Phe Ile Tyr Thr Pro Val Lys Pro Ile Asp Leu Gly Val 370 375 380 Glu Tyr Val Asn Gly Lys Arg Asp Thr Phe Asp Gly Lys Ser Tyr Lys 385 390 395 400 Asp Asn Arg Val Gly Leu Met Ala Lys Tyr Ser Phe 405 410 <210> SEQ ID NO 32 <211> LENGTH: 233 <212> TYPE: PRT <213> ORGANISM: putative outer membrane protein <400> SEQUENCE: 32 Tyr Gln Ala Glu Val Gly Gly Ser Tyr Asn Tyr Leu Asp Pro Asp Asn 1 5 10 15 Gly Ser Ser Val Ser Lys Phe Gly Val Asp Gly Thr Tyr Tyr Phe Asn 20 25 30 Pro Val Gln Thr Arg Asn Ala Pro Leu Ala Glu Ala Ala Phe Leu Asn 35 40 45 Arg Ala Ser Asn Val Asn Ala His Val Asn Tyr Gly Asp Asn Ser Gly 50 55 60 Thr Lys Asp Thr Gln Tyr Gly Val Gly Val Glu Tyr Phe Val Pro Asn 65 70 75 80 Ser Asp Phe Tyr Leu Ser Gly Asp Val Gly Arg Asn Glu Arg Glu Ile 85 90 95 Asp Asn Thr Asn Ile Asp Ser Lys Val Thr Thr Tyr Ala Ala Glu Val 100 105 110 Gly Tyr Leu Pro Ala Pro Gly Leu Leu Leu Ala Leu Gly Val Lys Gly 115 120 125 Tyr Asp Glu Lys Asp Gly Lys Asp Gly Ala Asp Pro Thr Val Arg Ala 130 135 140 Lys Tyr Val Thr Gln Val Gly Gln His Asp Val Asn Leu Glu Ala Tyr 145 150 155 160 Gly Ala Phe Gly Asp Leu Asp Glu Tyr Lys Val Arg Gly Asp Tyr Tyr 165 170 175 Ile Asp Lys Thr Leu Ser Leu Gly Val Asp Tyr Tyr Asn Asn Asp Leu 180 185 190 Thr Asp Lys Asp Glu Phe Gly Ile Asn Ala Lys Lys Phe Leu Asn Gln 195 200 205 Gln Val Ser Val Glu Gly Arg Val Gly Phe Gly Asp Asn Asp Asn Thr 210 215 220 Tyr Gly Val Arg Ala Ala Tyr Arg Phe 225 230 <210> SEQ ID NO 33 <211> LENGTH: 364 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 33 Met Gly Cys Ser Ser Asn Pro Ser Lys Lys Glu Val Val Asp Thr Gly 1 5 10 15 Pro Gln Ser Ser Glu Gln Ala Tyr Phe Asp Lys Ala Gln Lys Ala Leu 20 25 30 Asp Arg Gly Gln Tyr Leu Asp Ala Thr Lys Ser Leu Glu Ala Ile Asp 35 40 45 Thr Tyr Tyr Pro Thr Gly Gln Tyr Ala Gln Gln Ala Gln Leu Glu Leu 50 55 60 Leu Tyr Ser Lys Phe Lys Gln Lys Asp Tyr Glu Gly Ala Ile Ala Leu 65 70 75 80 Ala Glu Arg Phe Ile Arg Leu Asn Pro Gln His Pro Asn Val Asp Tyr 85 90 95 Ala Tyr Tyr Val Arg Gly Val Ser Asn Met Glu Met Asn Tyr Asp Ser 100 105 110 Leu Leu Arg Tyr Thr Ser Leu Gln Gln Ser His Arg Asp Val Ser Tyr 115 120 125 Leu Lys Val Ala Tyr Gln Asn Phe Val Asp Leu Ile Arg Arg Phe Pro 130 135 140 Ser Ser Gln Tyr Ser Val Asp Ala Ala Gln Arg Met Lys Phe Ile Gly 145 150 155 160 Gln Glu Leu Ala Glu Ser Glu Met Asn Ala Ala Arg Phe Asn Val Lys 165 170 175 Arg Lys Ala Trp Ile Ala Ala Ala Glu Arg Ser Gln Trp Val Ile Glu 180 185 190 His Tyr Pro Gln Thr Pro Gln Val Pro Glu Ala Leu Ala Thr Leu Ala 195 200 205 Tyr Ser Tyr Asp Gln Leu Gly Asp Lys Ala Thr Ser Gln Gln Tyr Ile 210 215 220 Glu Val Leu Lys Leu Asn Tyr Pro Ser Leu Val Asn Lys Asn Gly Thr 225 230 235 240 Val Asn Met Arg Ala Ala Arg Lys Glu Gly Asn Trp Ile Asn Arg Ala 245 250 255

Thr Leu Gly Ile Leu Gly Arg Glu Ser Lys Ser Val Thr Pro Asp Thr 260 265 270 Thr Thr Ser Ser Glu Ala Glu Pro Lys Arg Ser Leu Leu Asn Arg Val 275 280 285 Ser Phe Gly Leu Ile Gly Asn Ser Gly Lys Glu Glu Thr Glu Glu Thr 290 295 300 Thr Asn Thr Pro Val Glu Ala Pro Lys Ser Glu Arg Ser Trp Thr Asn 305 310 315 320 Arg Leu Ser Phe Gly Leu Leu Asp Lys Pro Lys Pro Lys Ala Ala Glu 325 330 335 Gly Ala Thr Ile Ala Pro Ala Thr Ser Ser Ser Glu Ala Pro Ser Ala 340 345 350 Ser Pro Ala Asp Asn Glu Ala Asp Asp Ala Ala Gln 355 360 <210> SEQ ID NO 34 <211> LENGTH: 356 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 34 Met Lys Leu Ser Arg Ile Ala Leu Ala Thr Met Leu Val Ala Ala Pro 1 5 10 15 Leu Ala Ala Ala Asn Ala Gly Val Thr Val Thr Pro Leu Leu Leu Gly 20 25 30 Tyr Thr Phe Gln Asp Ser Gln His Asn Asn Gly Gly Lys Asp Gly Asn 35 40 45 Leu Thr Asn Gly Pro Glu Leu Gln Asp Asp Leu Phe Val Gly Ala Ala 50 55 60 Leu Gly Ile Glu Leu Thr Pro Trp Leu Gly Phe Glu Ala Glu Tyr Asn 65 70 75 80 Gln Val Lys Gly Asp Val Asp Gly Ala Ser Ala Gly Ala Glu Tyr Lys 85 90 95 Gln Lys Gln Ile Asn Gly Asn Phe Tyr Val Thr Ser Asp Leu Ile Thr 100 105 110 Lys Asn Tyr Asp Ser Lys Ile Lys Pro Tyr Val Leu Leu Gly Ala Gly 115 120 125 His Tyr Lys Tyr Asp Phe Asp Gly Val Asn Arg Gly Thr Arg Gly Thr 130 135 140 Ser Glu Glu Gly Thr Leu Gly Asn Ala Gly Val Gly Ala Phe Trp Arg 145 150 155 160 Leu Asn Asp Ala Leu Ser Leu Arg Thr Glu Ala Arg Ala Thr Tyr Asn 165 170 175 Ala Asp Glu Glu Phe Trp Asn Tyr Thr Ala Leu Ala Gly Leu Asn Val 180 185 190 Val Leu Gly Gly His Leu Lys Pro Ala Ala Pro Val Val Glu Val Ala 195 200 205 Pro Val Glu Pro Thr Pro Val Ala Pro Gln Pro Gln Glu Leu Thr Glu 210 215 220 Asp Leu Asn Met Glu Leu Arg Val Phe Phe Asp Thr Asn Lys Ser Asn 225 230 235 240 Ile Lys Asp Gln Tyr Lys Pro Glu Ile Ala Lys Val Ala Glu Lys Leu 245 250 255 Ser Glu Tyr Pro Asn Ala Thr Ala Arg Ile Glu Gly His Thr Asp Asn 260 265 270 Thr Gly Pro Arg Lys Leu Asn Glu Arg Leu Ser Leu Ala Arg Ala Asn 275 280 285 Ser Val Lys Ser Ala Leu Val Asn Glu Tyr Asn Val Asp Ala Ser Arg 290 295 300 Leu Ser Thr Gln Gly Phe Ala Trp Asp Gln Pro Ile Ala Asp Asn Lys 305 310 315 320 Thr Lys Glu Gly Arg Ala Met Asn Arg Arg Val Phe Ala Thr Ile Thr 325 330 335 Gly Ser Arg Thr Val Val Val Gln Pro Gly Gln Glu Ala Ala Ala Pro 340 345 350 Ala Ala Ala Gln 355 <210> SEQ ID NO 35 <211> LENGTH: 581 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 35 Met Asn Gln Glu Thr Gly Arg Gly Val Thr Arg Gly Thr Lys Leu Tyr 1 5 10 15 Val Lys Asp Val Pro Val Leu Ala Val Pro Tyr Phe Asn Phe Pro Ile 20 25 30 Asp Asp Arg Arg Thr Thr Gly Ile Leu Asn Pro Gln Phe Gly Phe Ser 35 40 45 Asn Asp Gly Gly Ile Glu Leu Ser Val Pro Val Tyr Leu Asn Leu Ala 50 55 60 Pro Asn Tyr Asp Ala Thr Ile Thr Pro Arg Tyr Leu Ala Asp Arg Gly 65 70 75 80 Ala Met Leu Gln Gly Glu Phe Arg Tyr Leu Thr Asp Gly Phe Gly Ala 85 90 95 Gly Gln Ile Trp Gly Gly Ile Leu Pro Ser Asp Lys Glu Tyr Asp Asp 100 105 110 Lys Asp Arg Lys Asp Phe His Phe Leu His Asn Trp Asp Ile Asn Asp 115 120 125 Gln Trp Ser Thr Asn Leu Glu Tyr Asn Tyr Ala Ser Asp Lys Asp Tyr 130 135 140 Phe Ser Asp Leu Asp Ser Ser Pro Ile Ser Lys Thr Asp Leu Asn Leu 145 150 155 160 Arg Arg Ala Trp Glu Leu Asn Tyr Gln His Gly Ile Pro Gly Leu Lys 165 170 175 Ala Gln Leu Lys Val Glu Asp Phe Gln Thr Leu Asp Pro Gln Val Lys 180 185 190 Asp Ala Asp Lys Pro Tyr Ala Arg Leu Pro Gln Phe Leu Leu Asn Tyr 195 200 205 Val Thr Gly Asn Pro Leu Gly Leu Gln Tyr Glu Phe Asn Asn Asp Thr 210 215 220 Ala Tyr Phe Lys Lys Ser Ile Asn Asp Asn Ser Ala Gln Glu Ser Ser 225 230 235 240 Gly Thr Arg Ile Tyr Asn Gln Phe Ala Thr Arg Tyr Asn Tyr Arg Thr 245 250 255 Pro Ala Ala Phe Val Ile Pro Glu Val Ser Val Arg Ser Ile Gln Thr 260 265 270 Phe Tyr Asp Lys Asp Thr Gln Leu Asn Asn Pro Gly Gly Ser Glu Asn 275 280 285 Lys Ser Val Val Val Pro Gln Phe Thr Leu Asp Thr Gly Leu Asn Phe 290 295 300 Glu Arg Glu Gly Lys Tyr Leu Gln Thr Leu Thr Pro Arg Ala Phe Tyr 305 310 315 320 Ala Tyr Ala Pro Tyr Lys Asn Gln Asp Gly Tyr Pro Asn Phe Asp Ser 325 330 335 Thr Thr Ala Ser Ile Ser Tyr Asp Gln Leu Phe Asn Pro Tyr Arg Phe 340 345 350 Tyr Gly His Asp Arg Leu Glu Asp Asn Asn Phe Leu Ser Leu Gly Val 355 360 365 Ser Tyr Ser Leu Phe Asp Thr Val Gly Leu Glu Arg Leu Arg Ala Ser 370 375 380 Val Gly Gln Ser Tyr Tyr Phe Glu Asp Arg Arg Val Thr Leu Lys Gln 385 390 395 400 Gly Gln Asp Glu Phe Asp Thr Glu Arg Lys Thr Gly Pro Val Ile Ser 405 410 415 Leu Ser Ser Gln Leu Asn Gln Asn Phe Thr Ile Ala Ala Asn Ser Ala 420 425 430 Trp Met Ser Asn Gly Asp Asn Ala Gln Arg Asp Phe Gln Val Tyr Tyr 435 440 445 Thr Gly Asp Lys Gly Asn Leu Tyr Asn Leu Gly Tyr Phe Tyr Arg Lys 450 455 460 Asp Ile Pro Gly Arg Gln Asp Thr Tyr Asp Gln Val Val Ala Ser Phe 465 470 475 480 Ile Gln Pro Ile Lys Asp Asn Trp Arg Ile Met Gly His Val Gln Tyr 485 490 495 Asp Met Asp Asn Asp Val Ala Arg Glu Leu Leu Leu Gly Val Asn Tyr 500 505 510 Glu Ser Cys Cys Trp Gly Ile Ser Val Tyr Gly Arg Ser Tyr Tyr Asn 515 520 525 Asp Leu Asp Asp Pro Lys Thr Ser Asp Val Ser Glu Lys Arg Ala Ile 530 535 540 Met Ala Glu Ile Thr Leu Lys Gly Leu Gly Gly Leu Asn Asn Lys Leu 545 550 555 560 Ala Ser Leu Leu Glu Asn Arg Phe Leu Gly Phe Asn Lys Ile Asn Gln 565 570 575 Ser Trp Thr Gln Arg 580 <210> SEQ ID NO 36 <211> LENGTH: 747 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 36 Met Ser Ser Glu Lys Arg Asp Leu Thr Asn Phe Ser Arg Phe Leu Val 1 5 10 15 Asn Ile Asn Tyr Val Asp Phe Pro Glu Tyr Ala Lys Leu Pro Leu Ile 20 25 30 Gln Asn Phe Arg Asp Phe Lys His Phe Lys Thr Ala Ile Asp Trp Ser 35 40 45 Asn Lys Phe Asn Ile Gln Lys Ser Val Asp Gly Arg Ile Leu Leu Ser 50 55 60 Val Leu Tyr Ala Glu Ala Gln Asp Val Ala Asn Ala Lys Asp Gln Leu 65 70 75 80 Ser Lys Ile Asp Ile Lys Gly Leu Thr Ala Asp Gln Leu Val Arg Val 85 90 95 Ala Tyr Ala Tyr Arg Leu Ile Asn Leu Pro Val Asp Ala Leu Ala Thr 100 105 110 Val Glu His Ala Tyr Gln Gln Gln Pro Lys Ser Leu Ser Val Leu Gln 115 120 125 Glu Tyr Val Tyr Asp Leu Ile Ala Ile Gly Ser Tyr Lys Lys Ala Gln

130 135 140 Gln Leu Leu Gln Ala Ser Glu Lys Thr Glu Gln Thr Val Gln Met Leu 145 150 155 160 Lys Thr Leu Gln Val Ser Glu Phe Ser Gln His Ile Asn Asn Ala Ile 165 170 175 Ala Arg Tyr Lys Tyr Leu Asn Arg Glu Gly Leu Ser Asp Ala Glu Ser 180 185 190 Phe Ala Glu Leu Asp Lys Val Leu Glu Gln Gly Gln Lys Met His Gln 195 200 205 Gln Met Asn Pro Ser Asp Pro Asn Tyr Leu Arg Phe Tyr Tyr Asp Tyr 210 215 220 Leu Tyr Gly Leu Asp Phe Arg Gly Arg Ser Lys Ala Val Ile Glu Ser 225 230 235 240 Phe Thr Gln Leu Asn Ile Pro Leu Glu Lys Leu Pro Ala Tyr Val Arg 245 250 255 His Ala Ile Ala Asp Ser Tyr Leu Ala Glu Gln Lys Pro Lys Gln Ala 260 265 270 Glu Phe Ala Tyr Lys Thr Leu Leu Thr Glu Lys Asn Tyr Pro Asp Met 275 280 285 Thr Val Tyr Thr Gly Leu Tyr Tyr Ser Tyr Ile Glu Gln Glu Lys Tyr 290 295 300 Lys Glu Ala Glu Gln Leu Leu Ala Glu Val Asp Arg Leu Ile Pro Thr 305 310 315 320 Tyr Lys Tyr Ser Gln Ala Lys Gly Val Asp Lys Ile Ser His Pro Asp 325 330 335 Arg Asp Asp Tyr Ile Ala Leu Gln Gly Met His Leu Ala Tyr Ala Asn 340 345 350 His Leu Asp Gln Ala Glu Lys His Phe Gln Lys Lys Val Glu Gln Ala 355 360 365 Pro Ala Asn Glu Ser Leu Ile Asn Asn Leu Ala Arg Val Glu Arg Trp 370 375 380 Arg Glu Lys Pro Leu Glu Ala Lys Lys Thr Ile Ser Arg Leu Asn Gly 385 390 395 400 Ile Asp Pro Ile Ala Lys Asp Thr Arg Ile Asn Glu Met Gln Asn Ala 405 410 415 Gln Ala Leu Gly Asp Ile Pro Thr Trp Arg Lys Thr Thr Gln Asn Leu 420 425 430 Val Gln Tyr Tyr Pro Asp Asp Ser Gly Val Ile Lys Ser Arg Lys Glu 435 440 445 Leu Glu Asp Arg Asn Arg Ala Thr Ile Ser His Ser Thr Thr Trp Gly 450 455 460 Gln Ser Lys Ala Asp Gly Arg Asp Thr Val Ser Gly Gln Asn Gly Leu 465 470 475 480 Lys Asp Arg Glu Met Glu Thr Arg Leu Asn Ser Pro Trp Ile Asn Asp 485 490 495 Asn Tyr Arg Leu Phe Ala Trp His Gln Asp Arg Tyr Gly Glu Tyr Arg 500 505 510 Phe Gly Asp Val His Asp Gln Arg Tyr Gly Val Gly Ala Glu Trp Gln 515 520 525 Ala Asn Arg Lys Ala Leu Ser Ala Ile Val Ser Gln Ser Thr Asp Gly 530 535 540 Gly Gln Ala Gly Val Arg Leu Asp Trp Ser Gln Trp Leu Asn Asp His 545 550 555 560 Trp Gln Tyr Gln Leu Gln Tyr Asn Ser Gln Ala Asp Ile Pro Leu Gln 565 570 575 Ala Leu Asp Ala Gly Glu Asp Gly Gln Ser Tyr Arg Ala Ala Val Thr 580 585 590 Trp Gln Lys Asp Glu Ser Arg Gln Ile Gly Ala Ser Tyr Gly Leu Thr 595 600 605 Asp Ile Ser Asp Gly Asn Lys Gln Gln Glu Phe Ser Thr Phe Trp Arg 610 615 620 Glu Arg Leu Phe Asp Ala Pro His His Ile Thr Tyr Gly Thr Val Arg 625 630 635 640 Gly Phe Tyr Gly Thr Asn Ser Gln Asp Gln Thr Ala Tyr Phe Ser Pro 645 650 655 Ser Ser His Tyr Ser Ala Glu Leu Asn Leu Ser His Asp Trp Val Thr 660 665 670 Trp Arg Glu Tyr Glu Arg Ser Phe Lys Gln His Phe Glu Ala Gly Val 675 680 685 Gly Leu Tyr Lys Gln Ala Asp Tyr Ser Ala Lys Pro Thr Tyr Ser Leu 690 695 700 Gln Tyr Gln His Gln Trp Gln Leu Ser Arg Thr Trp Gln Leu Asn Tyr 705 710 715 720 Gly Ile Gly Trp Gln Tyr His Pro Tyr Asp Gly His Asp Glu Gln His 725 730 735 Thr Tyr Gly Ile Phe Gly Phe Glu Gly Arg Phe 740 745 <210> SEQ ID NO 37 <211> LENGTH: 381 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 37 Met Leu Gly Asp Trp Asn Gly Gln Arg Thr Ala Leu Gln Ala Gln Gly 1 5 10 15 Tyr Asp Phe Ser Phe Gly Tyr Thr Gly Glu Tyr Ala Gly Ile Leu Asp 20 25 30 Ser Lys Gln Thr Ser Thr His Gly Ser Ala Tyr Thr Gly Gln Leu Ala 35 40 45 Leu Gly Ser His Leu Asp Leu Gly Lys Ile Leu Gly Trp Gln Asp Thr 50 55 60 Glu Ala Gln Ile Thr Leu Thr Tyr Arg Asp Gly Gln Ser Leu Ser Glu 65 70 75 80 His Ser Pro Ala Leu Ala Gly His Gln Ser Ser Val Gln Glu Val Trp 85 90 95 Gly Arg Glu Gln Thr Trp Arg Leu Thr Asp Leu Trp Ile Lys Lys Lys 100 105 110 Phe Leu Asp Gln Lys Leu Asp Val Lys Val Gly Arg Phe Gly Glu Gly 115 120 125 Glu Asp Phe Asn Ser Phe Asp Cys Asp Phe Gln Asn Leu Ala Leu Cys 130 135 140 Gly Ser Gln Val Gly Asn Trp Val Gly Asp Gln Trp Tyr Asn Trp Pro 145 150 155 160 Val Ser Gln Trp Ala Met Arg Val Lys Tyr Asn Leu Gln Pro Asp Leu 165 170 175 Tyr Thr Gln Val Gly Val Tyr Glu Tyr Asn Pro Glu Asn Leu Glu Arg 180 185 190 Gly Lys Gly Phe Asn Leu Ser Thr Asp Gly Ser His Gly Ala Ile Ile 195 200 205 Pro Ala Glu Val Val Trp Ser Pro Lys Leu Gly Val Gln Ser Met Pro 210 215 220 Gly Glu Tyr Arg Leu Gly Tyr Tyr Tyr Ser Thr Ala Asp Ala Lys Glu 225 230 235 240 Ile Ala Asp Ser Thr Lys Thr Ser His Lys Gln Gly Val Trp Val Thr 245 250 255 Ala Lys Gln Lys Leu Phe Gln Pro Ala Asp Gln Thr Asp Arg Gly Leu 260 265 270 Thr Gly Phe Val Asn Leu Thr Phe His Asp Ser Asp Thr Asn Lys Val 275 280 285 Asp Asn Met Gln Asn Ile Gly Leu Val Tyr Lys Gly Leu Leu Asn Gln 290 295 300 Arg Pro Gln Asp Glu Leu Ala Leu Gly Val Ala Arg Ile His Ile Asn 305 310 315 320 Asp Asp Trp Ser Asp Val Gln Ala Lys Glu Tyr Asp Thr Glu Tyr Asn 325 330 335 Thr Glu Leu Tyr Tyr Gly Ile His Ala Thr Asn Trp Leu Thr Ile Arg 340 345 350 Pro Asn Val Gln Tyr Val Arg His Val Gly Ala Leu Lys Asn Gly Asp 355 360 365 Asn Thr Trp Val Gly Gly Ile Lys Phe Ser Thr Ala Phe 370 375 380 <210> SEQ ID NO 38 <211> LENGTH: 183 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 38 Met Leu Phe Arg Thr Gly Leu Ala Asp Gly Leu Glu Leu Gln Leu Gly 1 5 10 15 Trp Gln Gly Pro Ala Trp Thr Gln Thr Lys Arg Ala Gly Lys Lys Thr 20 25 30 Asp Asn Ser Gly Phe Gly Asp Val Ser Ile Gly Leu Lys Lys Ala Ile 35 40 45 Asp Leu Asn Asp Glu Asn Leu Thr Met Ala Val Leu Ala Glu Ala Val 50 55 60 Ile Ala Thr Gly Asn Asp Glu Phe Thr Ala His Asp Asp Ile Tyr Ser 65 70 75 80 Leu Ser Ser Ala Val Ala Tyr Lys Tyr Asn Asp Leu Leu Asp Thr Ser 85 90 95 Ile Thr Met Arg Tyr Glu Val Gln Asn Ser Asn Trp Ala Val Thr Ala 100 105 110 Ile Pro Thr Ile Asn Tyr Lys Ile Ala Gly Lys Leu Ser Gly Tyr Ser 115 120 125 Glu Phe Val Tyr Arg Lys Ala Glu Ser Gln Asp Tyr Gln Tyr Gly Leu 130 135 140 Gly Thr Gly Leu Val Tyr Ala Val Asn Asn Arg Thr Gln Leu Asp Ala 145 150 155 160 Asn Ile Gly Val Asp Leu Glu Gly Gln Asp Lys Ser Tyr Lys Gly Gly 165 170 175 Leu Gly Met Ala Phe Leu Phe 180 <210> SEQ ID NO 39 <211> LENGTH: 217 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 39 Met Arg Ala Leu Val Ile Ser Thr Val Val Gly Ala Ala Val Val Leu 1 5 10 15

Ser Gly Cys Gln Thr Thr Gly Asn Asn Leu Gly Gly Val Glu Tyr Asp 20 25 30 Lys Ala Ala Leu Gly Thr Leu Ile Gly Ala Ala Ala Gly Tyr Gly Ile 35 40 45 Ser Lys Ser Asn Ala Asn Ser Ser Arg Gln Asn Asn Arg Ala Ala Ala 50 55 60 Ile Gly Ala Val Leu Gly Ala Ala Gly Gly Leu Tyr Leu Asp Gln Lys 65 70 75 80 Glu Lys Lys Leu Arg Glu Gln Met Ala Gly Thr Gly Val Glu Val Gly 85 90 95 Arg Asn Pro Asp Gly Ser Val Gln Leu Ile Met Pro Gly Ser Ile Thr 100 105 110 Phe Asp Thr Asn Lys Ser Asn Ile Lys Pro Asn Phe Tyr Ala Thr Leu 115 120 125 Asp Lys Val Ala Gln Thr Leu Ala Glu Asp Asn Lys Ser Ala Ile Leu 130 135 140 Val Thr Gly Tyr Thr Asp Asn Thr Gly Asn Asp Ser Ile Asn Ile Pro 145 150 155 160 Leu Ser Gln Ala Arg Ala Gln Ser Val Lys Asn Tyr Leu Ala Gly Lys 165 170 175 Gly Val Pro Ser Ser Arg Ile Asp Ala Gln Gly Tyr Gly Ser Ser Asn 180 185 190 Pro Ile Ala Asp Asn Ser Thr Ala Ser Gly Arg Glu Gln Asn Arg Arg 195 200 205 Val Glu Ile Ser Ile Tyr Ala Lys Gln 210 215 <210> SEQ ID NO 40 <211> LENGTH: 299 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 40 Met Lys Lys Leu Gly Leu Ala Thr Ala Val Leu Leu Ala Met Thr Gly 1 5 10 15 Ala His Ala Tyr Gln Phe Glu Val Gln Gly Gln Ser Glu Tyr Val Asp 20 25 30 Thr Thr Ala Asn Asp Lys Asn Phe Thr Gly Asp Val Ala Gly Thr Phe 35 40 45 Tyr Leu Lys Asn Val Asp Thr Ala Lys Gly Pro Leu Ala Glu Ala Ala 50 55 60 Phe Leu Asn Gln Ala Ser Ser Val Ser Leu Gly Tyr Ser Tyr Gln Gln 65 70 75 80 Tyr Asp Gln Asn Asn Val Asn Tyr His Ile Gly Thr Tyr Gly Val Lys 85 90 95 Gly Glu Ala Tyr Val Pro Thr Pro Tyr Leu Pro Val Tyr Ala Ser Ala 100 105 110 Thr Tyr Asn His Thr Asp Val Asp Gly Lys Asn Asn Phe Ser Lys Asp 115 120 125 Asp Asn Gly Asp Arg Tyr Ala Leu Glu Val Gly Ala Met Leu Leu Pro 130 135 140 Asn Phe Leu Met Thr Val Gly Tyr Thr Ser Val Ala Asn Gln Phe Ala 145 150 155 160 Leu Asp Asn Phe Gly Ile Ile Gly Asn Gly Ile Tyr Ser Ala Val Asn 165 170 175 Gln Thr Ala Ala Ile Gln Asn Asp Gln Asp Ala Val Thr Ala Arg Ala 180 185 190 Lys Tyr Val Gly Pro Ile Asp Gly Thr Asn Met Ala Ile Gly Phe Glu 195 200 205 Ala Ala Gly Ala Phe Gly Gln Glu Asn Gln Tyr Gly Leu Lys Thr Asp 210 215 220 Leu Tyr Leu Thr Pro Lys Leu Ser Val Gly Ala Thr Phe Val Gly Asn 225 230 235 240 Asp Gly Glu Ala Asp Ile Lys Gly Asn Asp Leu Gly Glu Phe Arg Gln 245 250 255 Ala Trp Gly Gly Asn Val Asn Tyr Phe Ile Thr Pro Ala Leu Ala Val 260 265 270 Gly Ala Ser Tyr Met Lys Ala Asp Val Lys Lys Ser Ser Tyr Asp Thr 275 280 285 Gln Thr Ile Gly Leu Asn Ala Lys Phe Arg Phe 290 295 <210> SEQ ID NO 41 <211> LENGTH: 228 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 41 Asp Glu Ala Val Val His Asp Ser Tyr Ala Phe Asp Lys Asn Gln Leu 1 5 10 15 Ile Pro Val Gly Ala Arg Ala Glu Val Gly Thr Thr Gly Tyr Gly Gly 20 25 30 Ala Leu Leu Trp Gln Ala Asn Pro Tyr Val Gly Leu Ala Leu Gly Tyr 35 40 45 Asn Gly Gly Asp Ile Ser Trp Thr Asp Asp Val Ser Val Asn Gly Thr 50 55 60 Lys Tyr Asp Leu Asp Met Asp Asn Asn Asn Val Tyr Leu Asn Ala Glu 65 70 75 80 Ile Arg Pro Trp Gly Ala Ser Thr Asn Pro Trp Ala Gln Gly Leu Tyr 85 90 95 Ile Ala Ala Gly Ala Ala Tyr Leu Asp Asn Asp Tyr Asp Leu Ala Lys 100 105 110 Arg Ile Gly Asn Gly Asp Thr Leu Ser Ile Asp Gly Lys Asn Tyr Gln 115 120 125 Gln Ala Val Pro Gly Gln Glu Gly Gly Val Arg Gly Lys Met Ser Tyr 130 135 140 Lys Asn Asp Ile Ala Pro Tyr Leu Gly Phe Gly Phe Ala Pro Lys Ile 145 150 155 160 Ser Lys Asn Trp Gly Val Phe Gly Glu Val Gly Ala Tyr Tyr Thr Gly 165 170 175 Asn Pro Lys Val Glu Leu Thr Gln Tyr Asn Leu Ala Pro Val Thr Gly 180 185 190 Asn Pro Thr Ser Ala Gln Asp Ala Val Asp Lys Glu Ala Asn Glu Ile 195 200 205 Arg Asn Asp Asn Lys Tyr Glu Trp Met Pro Val Gly Lys Val Gly Val 210 215 220 Asn Phe Phe Trp 225 <210> SEQ ID NO 42 <211> LENGTH: 609 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 42 Met Gly Phe Asn Ser Ile Gln Ser Gly Gly Thr Asn Gly Asp Val Thr 1 5 10 15 Phe Arg Gly Met Phe Gly Ser Arg Ile Lys Ile Leu Thr Asp Gly Thr 20 25 30 Glu Asn Leu Gly Ala Cys Pro Asn Arg Met Asp Ala Pro Thr Ser Tyr 35 40 45 Ile Ser Pro Glu Ser Tyr Asp Arg Ile Ser Val Ile Lys Gly Pro Gln 50 55 60 Thr Val Gln Tyr Ala Asn Thr Gly Ser Ala Ala Thr Val Leu Phe Glu 65 70 75 80 Arg Gln Pro Glu Lys Leu Thr Ser Glu Lys Pro Tyr Arg Gly Gln Ala 85 90 95 Ser Val Leu Leu Gly Ser Tyr Gly Arg Ile Asp His Asn Ile Glu Ala 100 105 110 Ala Val Gly Asp Glu Lys Lys Tyr Ile Arg Leu Asn Ala Asn Arg Ser 115 120 125 Glu Ser Asn Ser Tyr Gln Asp Gly Asp Gly Asn Thr Val Pro Ser Ala 130 135 140 Trp Lys Lys Trp Asn Ala Asp Val Ala Leu Gly Phe Thr Pro Asp Glu 145 150 155 160 Asn Thr Trp Val Glu Ile Thr Gly Gly Lys Ser Asp Gly Glu Ser Leu 165 170 175 Tyr Ala Gly Arg Ser Met Asp Gly Ser Gln Phe Ala Arg Glu Ser Leu 180 185 190 Gly Leu Arg Phe Glu Lys Lys Asn Ile Thr Asp Val Ile Lys Lys Ile 195 200 205 Glu Gly Gln Val Asn Tyr Ser Tyr Asn Asp His Val Met Asp Asn Phe 210 215 220 Arg Leu Arg Ile Pro Pro Met Thr His Asp Met Met Thr His Gln Met 225 230 235 240 Val Val Asn Pro Ser Glu Met Gln Val Thr Arg Arg Thr Leu Asn Thr 245 250 255 Arg Phe Ala Met Thr Ser Glu Trp Gly Lys Leu Asn Val Ile Thr Gly 260 265 270 Ile Asp Ser Gln Gln Asn His His Ala Glu Ser Met Lys Ser Leu Met 275 280 285 Met Asp Met Pro Leu Thr Thr Asn Met Lys Phe Gln Ser Tyr Gly Ala 290 295 300 Phe Gly Glu Leu Gly Tyr Gln Leu Ser Glu Asn Ser Lys Leu Val Thr 305 310 315 320 Gly Ala Arg Leu Asp Gln Val Lys Ile Asp Ala Leu Lys Leu Asn Asp 325 330 335 Asp Arg Ser Glu Thr Leu Pro Ser Gly Phe Ile Arg Leu Glu Thr Gln 340 345 350 Leu Pro Glu His Asn Ala Lys Ser Tyr Ile Gly Leu Gly Tyr Val Glu 355 360 365 Arg Val Pro Asp Tyr Trp Glu Leu Phe Ser Thr Ala His Gly Asn Ser 370 375 380 Gly Met Pro Lys Pro Thr Phe Asn Asp Leu Asp Thr Glu Lys Thr Leu 385 390 395 400 Gln Leu Asp Met Gly Tyr Gln His Gln His Gly Ala Phe Asn Ser Trp 405 410 415 Ala Ser Ala Tyr Val Gly Leu Ile Asn Asp Tyr Ile Leu Met Ser Tyr 420 425 430 His Asn His Pro Thr Ser Gly Gly His Gly His Gly Ser Ser Phe Ser 435 440 445 Ala Gly Ala Lys Asn Val Asp Ala Thr Ile Ala Gly Ala Glu Ala Gly 450 455 460

Ile Gly Tyr Gln Phe Thr Asp Arg Ile Gln Ala Asp Leu Ser Ala Met 465 470 475 480 Tyr Ala Trp Gly Lys Asn Thr Thr Asp Asp Lys Pro Leu Pro Gln Ile 485 490 495 Ser Pro Leu Glu Gly Arg Leu Asn Ile Arg Tyr Val Ala Asp Lys Tyr 500 505 510 Asn Leu Gly Leu Leu Trp Arg Ala Val Ala Glu Gln Asn Arg Val Ser 515 520 525 Leu His Gln Gly Asn Ile Val Gly Tyr Asp Leu Lys Pro Ser Lys Gly 530 535 540 Phe Ser Thr Leu Ser Leu Asn Gly Ser Tyr Asn Leu Arg Lys Asp Ile 545 550 555 560 Asp Val Ser Val Gly Ile Asp Asn Val Leu Asp Lys Thr Tyr Thr Glu 565 570 575 His Leu Asn Lys Ala Gly Ser Ala Gly Phe Gly Phe Ala Ser Glu Glu 580 585 590 Gln Phe Asn Asn Ile Gly Arg Asn Tyr Trp Val Arg Met Ser Met Lys 595 600 605 Phe <210> SEQ ID NO 43 <211> LENGTH: 170 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 43 Met Thr Gly Cys Ala Ser Arg Lys Pro Ala Thr Thr Ala Thr Thr Gly 1 5 10 15 Thr Thr Asn Pro Ser Thr Val Asn Thr Thr Gly Leu Ser Glu Asp Ala 20 25 30 Ala Leu Asn Ala Gln Asn Leu Ala Gly Ala Ser Ser Lys Gly Val Thr 35 40 45 Glu Ala Asn Lys Ala Ala Leu Ala Lys Arg Val Val His Phe Asp Tyr 50 55 60 Asp Ser Ser Asp Leu Ser Thr Glu Asp Tyr Gln Thr Leu Gln Ala His 65 70 75 80 Ala Gln Phe Leu Met Ala Asn Ala Asn Ser Lys Val Ala Leu Thr Gly 85 90 95 His Thr Asp Glu Arg Gly Thr Arg Glu Tyr Asn Met Ala Leu Gly Glu 100 105 110 Arg Arg Ala Lys Ala Val Gln Asn Tyr Leu Ile Thr Ser Gly Val Asn 115 120 125 Pro Gln Gln Leu Glu Ala Val Ser Tyr Gly Lys Glu Ala Pro Val Asn 130 135 140 Pro Gly His Asp Glu Ser Ala Trp Lys Glu Asn Arg Arg Val Glu Ile 145 150 155 160 Asn Tyr Glu Ala Val Pro Pro Leu Leu Lys 165 170 <210> SEQ ID NO 44 <211> LENGTH: 480 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 44 Met Phe Leu Arg Lys Thr Leu Ser Ile Ala Leu Leu Ala Thr Ala Ser 1 5 10 15 Ser Ala Val Phe Ala Gln Gly Leu Val Leu Asn Asn Asp Asp Leu Arg 20 25 30 Thr Asp Leu Asn Trp Leu Asn Gln Gln Gly Val Ile Asn Ile Ser Thr 35 40 45 Ser Thr Trp Pro Leu Ser Gly Asp Glu Ile Gln Arg Ala Leu Ser Gln 50 55 60 Ala Lys Val Thr His Pro Ala Gln Gln Lys Val Ile Asn Ser Val Leu 65 70 75 80 Asn Ala Leu Lys Ala Asp Asn Asn Thr Val Lys Val Gly Ala Phe Ala 85 90 95 Glu Ser Asp Ile Lys Asn Ile Pro Gln Ala Phe Gly Asp Asn Gln Lys 100 105 110 Ser Gln Tyr Gln Gly Ser Leu Glu Phe Asn Ala Gly Gly Glu Asn Trp 115 120 125 Asp Ala Lys Ile Arg Val Asn Ala Glu Lys Asp Pro Gln Ile Asp Ser 130 135 140 Gly His Asp Val Asn Val Glu Gly Ser Tyr Val Ala Gly Lys Leu Trp 145 150 155 160 Asn Gln Trp Ile Val Ala Gly Gln Ile Pro Thr Trp Trp Gly Pro Gly 165 170 175 His Asp Gly Ser Leu Ile Arg Gly Asp Ala Ser Arg Pro Val Tyr Gly 180 185 190 Val Thr Ala Gln Arg Ala Val Gln Asn Ala Phe Glu Thr Lys Trp Leu 195 200 205 Ser Trp Ile Gly Pro Trp Gln Tyr Gln Ala Phe Ala Gly Gln Leu Asp 210 215 220 Asp Tyr Lys Ala Val Pro Asp Ala Lys Leu Ile Gly Leu Arg Leu Thr 225 230 235 240 Ala Gln Pro Leu Pro Tyr Leu Glu Leu Gly Ala Ser Arg Thr Ile Gln 245 250 255 Trp Gly Gly Asp Gly Arg Ser Glu Ser Phe Ser Ser Leu Trp Asp Ala 260 265 270 Ile Lys Gly Asn Asp Asn Val Tyr Gly Asp Thr Glu Asn Pro Ser Asn 275 280 285 Gln Leu Ala Gly Phe Asp Gly Arg Leu Leu Leu Gln Pro Leu Leu Asn 290 295 300 Ile Pro Val Ser Leu Tyr Gly Gln Tyr Val Gly Glu Asp Glu Ala Gly 305 310 315 320 Tyr Leu Pro Ser Lys Lys Met Tyr Leu Ala Gly Val Asp Tyr Ser Ser 325 330 335 Ser Tyr Asn Asp Met Pro Tyr Gln Leu Tyr Ala Glu Trp Ala Asp Thr 340 345 350 Arg Thr Asn Gly Asp Val Lys Ser Ile Ser Tyr Thr His Ser Val Tyr 355 360 365 Lys Asp Gly Tyr Tyr Gln His Gly Phe Pro Leu Gly His Ala Met Gly 370 375 380 Gly Asp Gly Gln Met Tyr Ser Val Gly Gly Asp Ile Arg Phe Asp Val 385 390 395 400 Met Asn Arg Leu Ser Gly Arg Ala Met Val Val Lys Val Asn Gln Ser 405 410 415 Asn Leu Ala Ile Asn Lys Ala Phe Pro Lys Asp Asp Glu Ile Lys Ala 420 425 430 Leu Asp Leu Thr Trp Thr His Tyr Ile Lys Pro Asp Leu Pro Leu Lys 435 440 445 Ile Asn Gly Trp Val Ser Asp Ser Asp Leu Glu Gly Asn Asp Ala Gly 450 455 460 Ala Ser Ile Gly Val Glu Ile Pro Leu Glu Arg Lys Met Phe Gly Phe 465 470 475 480 <210> SEQ ID NO 45 <211> LENGTH: 114 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 45 Met Asn Lys Leu Leu Val Ala Leu Gly Leu Ala Ala Thr Val Ala Leu 1 5 10 15 Val Gly Cys Asn Lys Asp Lys Ala Pro Glu Thr Gly Ala Thr Thr Gly 20 25 30 Glu His Leu Glu Asn Ala Ala Gln Gln Ala Thr Ala Asp Ile Lys Ser 35 40 45 Ala Gly Asp Gln Ala Ala Ser Asp Ile Ala Thr Ala Thr Asp Asn Ala 50 55 60 Ser Ala Lys Ile Asp Ala Ala Ala Asp His Ala Ala Asp Ala Thr Ala 65 70 75 80 Lys Ala Ala Ala Glu Thr Glu Ala Thr Ala Arg Lys Ala Thr Ala Asp 85 90 95 Thr Ala Gln Ala Val Glu Asn Ala Ala Ala Asp Val Lys Lys Asp Ala 100 105 110 Gln His <210> SEQ ID NO 46 <211> LENGTH: 725 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 46 Met Tyr Glu Tyr Pro Ser Tyr Asp Tyr Arg Gly Asn Phe Lys Ile Thr 1 5 10 15 Val Asp Pro Ser Gln Ile Lys Gln Asn Val Lys Ala Glu Asn Thr Ala 20 25 30 Lys Leu Asp Ala Glu Leu Gln Lys Lys Val Asp Gln Tyr Leu Arg Glu 35 40 45 Gln Lys Val Ala Leu Ser Lys Ala Gln Lys Gln Thr Leu Tyr Ala Ala 50 55 60 Ile Ala Asn Glu Gln Gly Asp Trp Gly Leu Thr Ser Ser Ala Arg Ser 65 70 75 80 Glu Lys Ile Asn Asn Ile Leu Ile Asn Leu Leu Asn Asp Leu Gln Phe 85 90 95 Ser Tyr Asp Gly Ser Ile His Tyr Arg Gln Lys Met Gly Ser Phe Asn 100 105 110 Leu Thr Ala Arg Tyr Glu Lys Pro Thr Leu Leu Val Gln Ala Lys Leu 115 120 125 Pro Met Val Leu Asp Leu Glu Asn Tyr Lys Phe Tyr Ile Asn Tyr Phe 130 135 140 Gly Leu Met Pro Tyr Leu Val Asn Lys Asp Asn Gln Asn Asn Leu Ala 145 150 155 160 Tyr Val Asp Phe Ser Lys Tyr Lys Ala Phe Phe Lys Asn Val Asp Lys 165 170 175 Lys Lys Phe Ile Glu Tyr Leu Lys Ala Ser Ser Ala Val Ser Tyr Arg 180 185 190 Leu Ala Glu Pro Gln Asn Leu Gln Arg Val Ser Leu Thr Glu Ala Asp 195 200 205 Arg Lys Ala Gly Ala Val Glu Arg Ile Arg Leu Lys Thr Thr Val Glu 210 215 220 Gln Leu Leu Leu Glu Val Asp Leu Phe Gly Gln Val Asn Glu Lys Tyr 225 230 235 240 Leu Gln Lys Ser Val Leu Gly Leu Asp Glu Glu Lys Leu Ala Glu Thr

245 250 255 Leu Ala Ala Glu Ile Ala Ala Ser Asp Ala Lys Lys Gly Thr Ala Gly 260 265 270 Lys Glu Glu Gln Lys Val Ser Ser Asp Asp Ala Ala Ala Val Ser Gln 275 280 285 Gln Leu Tyr Ser Leu Val Asn Ala His Leu Gly Asn Thr Ser Thr Ser 290 295 300 Glu Asp Glu Glu Val Glu Ser Ala Ser Ser Glu Glu Ala Ser Asp Val 305 310 315 320 Ala Val Ala Glu Ala Glu Gln Thr Ser Glu Asn Glu Glu Val Val Val 325 330 335 Leu Thr Glu Asp Gln Cys Ile Glu Leu Lys Ser Leu Lys Asn Pro Val 340 345 350 Ala Leu Gly Asp Ile Asn Tyr Cys Gln Ile Tyr Gly Ile Asp Val Leu 355 360 365 Asp Gln Ser Asp Thr Ser Ile Gln Lys Ala Gln Ile Lys Ser Arg Gln 370 375 380 Asp Ala Leu Lys Gln Thr Phe Glu Val Tyr Asn Gln Asn Gln Phe Ile 385 390 395 400 Asn Asp Glu Ala Phe Lys Val Leu Trp Leu Lys His Lys Asp Glu Ile 405 410 415 Glu Gln Ala Leu Pro Lys Gln Arg Asn Pro Ile Thr Ile Asp Val Ala 420 425 430 Leu Asp Asp Lys Gly Arg Ala Val Asn Met Asp Tyr Asp Val Asp Tyr 435 440 445 Thr Pro Ala Glu Phe Lys His Arg Phe Asn Ile Lys Ala Asp Met Gln 450 455 460 Ile Leu Asn Tyr Gly Lys Ala Thr Ser Ile Asp Gln Gln Gln Leu Lys 465 470 475 480 Gln Ala Lys Ser Val Ala Glu Ala Ser Lys Gly Ser Met Leu Glu Asn 485 490 495 Ile Ile Lys Gly Phe Ser Glu Lys Leu Gly Gln Ser Asp Val Ser Glu 500 505 510 His Pro Val Gly Thr His Ser Asp Val Gln Asp Leu Asp Ala Asn Leu 515 520 525 Ala Ile Leu Ala Asp Lys Thr Tyr Asp Ala Thr His Ala Tyr Asp Lys 530 535 540 Thr Tyr Lys Ala Val Phe Ile Ala Lys Leu Thr Ala Glu Lys Pro Ser 545 550 555 560 Tyr Ile Lys Tyr Tyr Ser Val Gln Gln Leu Gln Glu Ile Ala Glu Val 565 570 575 Tyr Ala Tyr Trp Phe Ser Asp Glu Asp Thr Tyr Asn Pro Gln Gly Lys 580 585 590 Ala Leu Glu Arg Ile Thr Ala Leu Gln Lys Lys His His Leu Glu Gln 595 600 605 Asp Asp Gln Phe Asp His Glu Leu Gly Arg Ala Val Asp His Ile Val 610 615 620 Leu Thr Thr Ile Gln Gly Lys Thr Gly Arg Glu Ala Trp Gln Arg Leu 625 630 635 640 Gln Lys Gln Tyr Lys Gln Pro Ala Gln Leu Phe Ser Lys Gln Tyr Gln 645 650 655 Leu Glu Phe Glu Lys Gln Asn Gly Val Ser Ala Glu Glu Lys His Leu 660 665 670 Leu Ser Glu Thr Ala Asp Ile Leu Gly Asn Val Tyr Val Ala Ala His 675 680 685 Lys Lys Gln Leu Ser Glu Lys Thr Ile Gln Asn Leu Lys Pro Glu His 690 695 700 Asn Glu Phe Ile Asp Tyr Glu Ile Phe Arg Glu Val Tyr Lys Gln Met 705 710 715 720 Val Ala Ala Arg Lys 725 <210> SEQ ID NO 47 <211> LENGTH: 746 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 47 Met Thr Pro Cys Cys Leu Ala Ile Ser Ala Ile Phe Ala Gln Gln Ala 1 5 10 15 Tyr Ala Glu Thr Val Thr Gln Thr Ala Glu Val Ser Glu Asn Ala Thr 20 25 30 Gln Lys Pro Val Ala Gln Leu Gln Lys Ile Val Val Thr Ala Thr Arg 35 40 45 Thr Pro Lys Asn Ile Ala Glu Ile Ala Gly Thr Val Gln Ser Ile Asp 50 55 60 Gln Lys Gln Ile Ile Gln Gln Ala Thr Ala Gly Arg Lys Val Ala Asp 65 70 75 80 Ile Leu Ala Gln Leu Val Pro Ser Leu Ala Ser Ser Ser Gly Thr Thr 85 90 95 Ser Asn Tyr Gly Gln Thr Met Arg Gly Arg Asn Val Leu Val Met Ile 100 105 110 Asp Gly Val Ser Gln Thr Gly Ser Arg Asp Val Ser Arg Gln Leu Asn 115 120 125 Ser Ile Ser Pro Gly Met Ile Glu Arg Ile Glu Val Ile Ser Gly Ala 130 135 140 Thr Ser Ile Tyr Gly Ser Gly Ala Thr Gly Gly Ile Ile Asn Ile Ile 145 150 155 160 Thr Lys Arg Ala Asp Thr Ser Lys Pro Leu Ser Phe Glu Thr Lys Val 165 170 175 Gly Ile Thr Ser Ser Asp Thr Phe Arg Ser Asp Gly Leu Ala Tyr Glu 180 185 190 Val Gly Gln Ser Val Ser Phe Asn Lys Gly Asn Ile Asp Gly Phe Leu 195 200 205 Gly Ala Asn Phe Thr Ser Arg Gly Ser Gln Phe Asp Gly Asn Gly Asp 210 215 220 Arg Ile Ser Leu Ser Pro Trp Gln Gly Ser Thr Met Asp Thr Asp Thr 225 230 235 240 Ile Asp Val Asn Gly Arg Leu Asn Phe Asn Leu Asn Asp Thr Gln Thr 245 250 255 Leu Ser Phe Gly Ala Gln Tyr Tyr Lys Asp Lys Gln Asp Thr Asp Tyr 260 265 270 Gly Pro Asp Tyr Ser Tyr Leu Pro Thr Thr Ser Lys Ser Asn Asp Ala 275 280 285 Thr Thr Pro Thr Tyr Lys Ala Ile Lys Gly Leu Lys Leu Ser Asn Pro 290 295 300 Leu Phe Thr Glu Arg Tyr Ala Val Asn Ser Gln Tyr Gln Asn Gln Asp 305 310 315 320 Phe Leu Gly Gln Ile Leu Asn Val Glu Ala Tyr Tyr Arg Asn Glu Lys 325 330 335 Ser Arg Phe Phe Pro Tyr Gly Leu Ser Asn Lys Ser Val Thr Ser Val 340 345 350 Asn Gln Ser Gln Ser Glu Ile Glu Val Ala Gly Leu Arg Ser Thr Met 355 360 365 Gln Thr Asp Leu Asn Ile Ala Asn Arg Asp Met Lys Ile Thr Tyr Gly 370 375 380 Leu Asp Tyr Asp Trp Glu Lys Asp Lys Gln Phe Val Asp Ile Leu Ala 385 390 395 400 Thr Gln Tyr Pro Tyr Leu Val Tyr Thr Pro Thr Gly Gln Arg Lys Gly 405 410 415 Tyr Gly Pro Asn Thr Glu Ile Gln Asn Ile Gly Ala Phe Val Gln Ser 420 425 430 Asp Tyr Ala Val Thr Asp Lys Leu Asn Leu Gln Ala Gly Ile Arg Tyr 435 440 445 Gln Tyr Ile Gln Ala Asp Thr Asp Ala Tyr Ile Pro Ser Arg Glu Thr 450 455 460 Thr Met Val Pro Ala Gly Ser Thr His Asp Asp Lys Pro Leu Phe Asn 465 470 475 480 Leu Gly Ala Val Tyr Lys Leu Thr Asp Ala Gln Gln Val Tyr Ala Asn 485 490 495 Phe Ser Gln Gly Phe Ser Phe Pro Asp Val Gln Arg Met Leu Arg Asp 500 505 510 Val Ser Thr Tyr Thr Val Ser Thr Ala Asn Leu Gln Pro Ile Thr Val 515 520 525 Asn Ser Tyr Glu Leu Gly Trp Arg Leu Asn Gln Asp Asp Gly Leu Asn 530 535 540 Leu Gly Leu Thr Gly Phe Tyr Asn Thr Ser Asp Lys Thr Val Gln Phe 545 550 555 560 Asn Asn Arg Ala Ala Lys Val Val Asp Thr Asp Gln Arg Val Tyr Gly 565 570 575 Ala Glu Ala Thr Ile Ser Tyr Pro Phe Met Glu Asn Tyr Lys Val Gly 580 585 590 Gly Thr Leu Gly Tyr Thr Arg Gly Gln Tyr Lys Asp Val Ala Asn Lys 595 600 605 Trp His Glu Leu Asn Ser Phe Thr Val Ala Pro Val Lys Gly Thr Leu 610 615 620 Phe Ala Glu Trp Asp Asn Asn Glu Gly Tyr Gly Val Arg Val Gln Met 625 630 635 640 Gln Ala Ile Lys Gly Thr Asn Lys Ala Tyr Lys Asp Asp Arg Glu Leu 645 650 655 Ala Ala Phe Ala Thr Thr Gln Asp Glu Ala Phe Gln Asn Ala Val Lys 660 665 670 Asn Asp Ala Asn Ser Ala Ala Gln Ile Lys Gly Tyr Thr Thr Met Asp 675 680 685 Val Leu Ala His Phe Pro Ala Trp Lys Gly Arg Val Asp Phe Gly Val 690 695 700 Tyr Asn Val Trp Asn Arg Gln Tyr Arg Thr Val Phe Ala Gln Gln Ala 705 710 715 720 Ala Val Ser Asn Ala Asn Pro Leu Leu Ala Ile Pro Ala Glu Gly Arg 725 730 735 Thr Tyr Gly Leu Ser Tyr Thr Phe Asn Tyr 740 745 <210> SEQ ID NO 48 <211> LENGTH: 476 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 48 Met Gly Ala Gln Leu Val Arg Glu Val Ser Ser Lys Thr Asn Asp Ile 1 5 10 15

Ala Gly Asp Gly Thr Thr Thr Ala Thr Val Leu Ala Gln Ala Ile Leu 20 25 30 Asn Glu Gly Ile Lys Ser Val Thr Ala Gly Met Asn Pro Met Asp Leu 35 40 45 Lys Arg Gly Ile Asp Ile Ala Val Lys Thr Val Val Glu Asn Ile Arg 50 55 60 Ser Ile Ala Lys Pro Ala Asp Asp Phe Lys Ala Ile Glu Gln Val Gly 65 70 75 80 Ser Ile Ser Ala Asn Ser Asp Thr Thr Val Gly Lys Leu Ile Ala Gln 85 90 95 Ala Met Glu Lys Val Gly Lys Glu Gly Val Ile Thr Val Glu Glu Gly 100 105 110 Ser Gly Phe Glu Asp Ala Leu Asp Val Val Glu Gly Met Gln Phe Asp 115 120 125 Arg Gly Tyr Ile Ser Pro Tyr Phe Ala Asn Lys Gln Asp Thr Leu Thr 130 135 140 Ala Glu Leu Glu Asn Pro Phe Ile Leu Leu Val Asp Lys Lys Ile Ser 145 150 155 160 Asn Ile Arg Glu Leu Ile Ser Val Leu Glu Ala Val Ala Lys Thr Gly 165 170 175 Lys Pro Leu Leu Ile Ile Ala Glu Asp Val Glu Gly Glu Ala Leu Ala 180 185 190 Thr Leu Val Val Asn Asn Met Arg Gly Ile Ile Lys Val Cys Ala Val 195 200 205 Lys Ala Pro Gly Phe Gly Asp Arg Arg Lys Ala Met Leu Gln Asp Ile 210 215 220 Ala Ile Leu Thr Gly Ala Thr Val Ile Ser Glu Glu Val Gly Met Ser 225 230 235 240 Leu Glu Gln Ala Thr Leu Gln Asp Leu Gly Thr Ala His Lys Ile Thr 245 250 255 Val Ser Lys Glu Asn Thr Val Ile Val Asp Gly Ala Gly Asp Ala Ala 260 265 270 Ala Ile Ala Glu Arg Val Gln Gln Ile Arg Ala Gln Ile Glu Glu Ser 275 280 285 Thr Ser Glu Tyr Asp Arg Glu Lys Leu Gln Glu Arg Val Ala Lys Leu 290 295 300 Ala Gly Gly Val Ala Val Ile Lys Ile Gly Ala Ala Thr Glu Val Glu 305 310 315 320 Met Lys Glu Lys Lys Asp Arg Val Asp Asp Ala Leu His Ala Thr Arg 325 330 335 Ala Ala Val Glu Glu Gly Val Val Ala Gly Gly Gly Val Ala Leu Val 340 345 350 Arg Ala Val Asn Ala Leu Glu Gly Leu Lys Gly Ala Asn Glu Asp Gln 355 360 365 Thr Ala Gly Ile Asn Ile Leu Arg Arg Ala Ile Glu Ala Pro Leu Arg 370 375 380 Gln Ile Val Ala Asn Ala Gly Asp Glu Pro Ser Val Val Ile Asn Ala 385 390 395 400 Val Lys Asn Gly Glu Gly Asn Phe Gly Tyr Asn Ala Ala Thr Gly Glu 405 410 415 Tyr Gly Asp Met Leu Glu Met Gly Ile Leu Asp Pro Ala Lys Val Thr 420 425 430 Arg Ser Ala Leu Glu His Ala Ala Ser Val Ala Gly Leu Met Leu Thr 435 440 445 Thr Glu Cys Met Ile Thr Asp Ile Pro Glu Asp Lys Pro Ala Ala Pro 450 455 460 Asp Met Gly Gly Met Gly Gly Met Gly Gly Met Met 465 470 475 <210> SEQ ID NO 49 <211> LENGTH: 472 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 49 Met Ser Ala Phe Phe Gln Pro Gly Asn Tyr Phe Glu Ala Gly Ile Ser 1 5 10 15 Val Leu Asp Pro Asp Val Ala Gly Lys Glu Ala Gly Ser Ser Ala Thr 20 25 30 Arg Arg Asp Ile Gly Asp Met Ala Asn Asp Tyr Tyr Phe Pro Ser Ala 35 40 45 Ala Leu Lys Leu Gln Ile Asn Asp Gln Phe Ser Phe Gly Leu Leu Tyr 50 55 60 Asp Gln Pro Phe Gly Ala Asp Ala Glu Tyr Ser Gly Asn Asn Val Phe 65 70 75 80 Val Ser Asn Pro Gly Ser Asp Thr Ile Leu Ser Gln Lys Ala Leu Gly 85 90 95 Asp Leu Ala Thr Ser Ser Ile Gln Lys Leu Val Gln Ala Ser Gly Ser 100 105 110 Ala Phe Thr Pro Ala Leu Ile Glu Val Thr Lys Val Thr Gly Gly Asp 115 120 125 Pro Thr Lys Pro Thr Gln Thr Glu Ile Leu Gly Ala Leu Gln Gln Val 130 135 140 Ala Ala Gly Gly Asn Thr Thr Val Gly Ala Gly Leu Thr Ala Leu Gln 145 150 155 160 Lys Thr Gln Ala Ala Ile Asn Ala Ala Asn Asn Tyr Leu Gly Thr Gly 165 170 175 Gly Thr Lys Val Lys Val Asp Thr Gln Asn Leu Ser Phe Val Phe Gly 180 185 190 Tyr Gln Pro Thr Lys Asn Phe Asn Phe Tyr Ala Gly Pro Val Leu Gln 195 200 205 Thr Val Lys Gly Asn Val Ser Leu Arg Gly Gln Ala Tyr Ser Leu Tyr 210 215 220 Asn Gly Tyr Asp Ala Asn Ile Lys Glu Thr Thr Gly Ala Gly Trp Leu 225 230 235 240 Ala Gly Ala Ala Tyr Gln Ile Pro Glu Ile Ala Leu Arg Ala Ser Val 245 250 255 Thr Tyr Arg Ser Glu Ile Asp His Lys Val Asn Ile Asp Glu Asn Leu 260 265 270 Ser Ile Leu Asn Phe Pro Gly Leu Thr Ser Val Leu Ala Gly Leu Asp 275 280 285 Val Pro Ala Ser Lys Leu Gln Ala Ile Asn Ser Ser Gly Lys Thr Thr 290 295 300 Ile Thr Thr Pro Gln Ser Val Asn Leu Asp Phe Gln Thr Gly Ile Met 305 310 315 320 Ala Asp Thr Val Ala Phe Ala Asn Val Arg Trp Val Asn Trp Lys Asp 325 330 335 Phe Ser Ile Gln Pro Tyr Lys Phe Gly Lys Val Ser Glu Ala Val Gly 340 345 350 Gly Leu Ile Gly Arg Pro Asn Gly Phe Asn Leu Val Glu Tyr Ser Asp 355 360 365 Asp Gln Trp Ser Val Asn Ala Gly Val Gly Arg Lys Leu Asn Asp Lys 370 375 380 Trp Ala Gly Asn Val Ser Val Gly Trp Asp Ser Gly Ala Gly Asn Pro 385 390 395 400 Val Thr Thr Leu Gly Pro Thr Glu Gly Tyr Trp Asn Val Gly Leu Gly 405 410 415 Val Gln Tyr Ser Pro Thr Pro Gln Thr Phe Ile Ala Gly Gly Val Lys 420 425 430 Tyr Phe Trp Leu Gly Asp Ala Lys Ala Gln Thr Gly Ala Gln Ala Gly 435 440 445 Ser Asp Glu Tyr Val Ala Asp Phe Ser Asp Asn Asn Ala Ile Ala Tyr 450 455 460 Gly Leu Lys Leu Gly Tyr Lys Phe 465 470 <210> SEQ ID NO 50 <211> LENGTH: 216 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 50 Met Val Phe Ala Gln Asp Asp Asn Ala Leu His Tyr Asn Ile Val Asn 1 5 10 15 Val Gln Ala Glu Ala Ser Arg Gln Val Ser Asn Asp Glu Met His Ala 20 25 30 Thr Leu Tyr Ile Glu Lys Ser Asn Lys Gln Pro Ala Glu Leu Ser Asn 35 40 45 Gln Ile Asn Gln Leu Met Asn Gln Ala Leu Ala Thr Ser Arg Lys Tyr 50 55 60 Pro Gln Val Lys Val Glu Thr Gly Ala Gln Ser Thr Tyr Pro Ile Tyr 65 70 75 80 Asp Asn Asp Ser Asn Lys Leu Lys Glu Trp Arg Gly Arg Ala Glu Ile 85 90 95 Arg Leu Glu Ser Lys Asp Phe Lys Ala Ala Ser Gln Leu Ile Asn Glu 100 105 110 Leu Gln Gln Ser Phe Gln Thr Gln Ser Ile Asn Phe Ser Val Ser Asp 115 120 125 Glu Gln Arg Lys Lys Val Glu Asn Glu Leu Met Val Glu Ala Ser Lys 130 135 140 Asn Phe Gln Gln Arg Ala Gln Met Leu Thr Gln Ala Trp Asn Lys Ser 145 150 155 160 Gln Tyr Ser Leu Val Thr Leu Asn Leu Asn Thr Asn Asn Tyr Phe Pro 165 170 175 Gln Pro Val Met Arg Ala Ser Leu Ala Lys Phe Ala Ala Ala Glu Ala 180 185 190 Ala Pro Ala Gln Asp Met Ala Ala Gly Glu Ser Lys Ile Thr Val Asn 195 200 205 Ala Asn Gly Ser Ile Gln Phe Lys 210 215 <210> SEQ ID NO 51 <211> LENGTH: 366 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 51 Met Lys Tyr Cys Gln Phe Phe Ser Val Leu Ala Leu Ser Leu Ser Ala 1 5 10 15 Ala Ser Cys Ala Val Thr Ser Gly Leu Gln Thr Tyr Asp Ile Pro Ser 20 25 30 Glu Gly Val Tyr Lys Thr Asp Leu Gly Thr Thr Val Asn Val Val Lys

35 40 45 Ile Ser Gln Glu Thr Leu Pro Ala Ile Gln Pro Ala Gln Ile Asp Tyr 50 55 60 Gln Arg Asp Tyr Ala Ser Leu Phe Lys Asn Gln Gln Ser Ile Tyr Arg 65 70 75 80 Leu Ser Pro Gly Asp Val Leu Ser Ile Gln Leu Trp Ala Tyr Pro Glu 85 90 95 Ile Thr Pro Pro Val Asn Asn Ile Ser Asn Glu Gln Ser Ile Gln Ala 100 105 110 Asn Gly Tyr Pro Ile Asp Gln Ser Gly Tyr Ile Gln Phe Pro Leu Val 115 120 125 Gly Arg Tyr Lys Ala Ala Gly Lys Thr Leu Ala Gln Val Asn Arg Glu 130 135 140 Leu His Ser Gln Leu Ala Arg Phe Leu Lys Asn Pro Asp Val Val Val 145 150 155 160 Arg Val Val Ser Tyr Glu Gly Gln Arg Phe Ser Val Gln Gly Ser Val 165 170 175 Thr Lys Gly Gly Gln Phe Tyr Leu Ser Asp Gln Pro Val Ser Ile Tyr 180 185 190 Thr Ala Leu Gly Met Ala Gly Gly Val Thr Thr Thr Gly Asp Asn Thr 195 200 205 Tyr Ile Gln Leu Ile Arg Asn Gly Arg Thr Tyr Asn Leu Asn Thr Ile 210 215 220 Asp Leu Glu Lys Ala Gly Tyr Ser Leu His Lys Leu Leu Val Gln Pro 225 230 235 240 Asn Asp Thr Ile Tyr Val Ser Thr Arg Glu Asn Gln Lys Ile Tyr Val 245 250 255 Met Gly Glu Ser Gly Lys Asn Gln Ala Leu Pro Met Arg Asp Gln Gly 260 265 270 Met Thr Leu Ser Asp Ala Leu Gly Glu Ser Leu Gly Ile Asn Pro Asn 275 280 285 Ser Ala Ser Ala Ser Arg Ile Tyr Val Val Arg Thr Asn Pro Asn Asp 290 295 300 Arg Thr Thr Glu Ile Tyr His Leu Asn Leu Met Ser Leu Gly Asp Phe 305 310 315 320 Gly Leu Ala Asn Gln Phe Arg Leu Arg Ser Asn Asp Ile Val Tyr Ile 325 330 335 Asp Ala Thr Gly Leu Thr Arg Trp Gln Arg Val Val Asn Gln Ile Ile 340 345 350 Pro Phe Ser Asn Ala Leu Tyr Asn Ile Asp Arg Leu Gly Gln 355 360 365 <210> SEQ ID NO 52 <211> LENGTH: 208 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 52 Met Leu Asp Arg His Val Leu Arg Pro Val Ala Val Glu Tyr Arg Glu 1 5 10 15 Lys Thr Pro Glu Asp Val Arg Gly Ser Tyr Arg Gln Phe Arg Lys Asn 20 25 30 Leu Gly Glu Pro Trp Asn Ala Val Asn Gln Leu Ile Gln Gly Arg Pro 35 40 45 Gly Arg Ala Ala Lys Thr Leu Gly Arg Phe Thr Ile Asn Thr Leu Thr 50 55 60 Thr Leu Gly Leu Ala Asp Pro Ala Ser Arg Leu Gly Leu Pro Pro Glu 65 70 75 80 Glu Glu Ser Phe Gly Val Thr Leu Gly Tyr Tyr Gly Val Pro Ser Gly 85 90 95 Pro Phe Leu Met Leu Pro Phe Phe Gly Pro Ser Thr Leu Arg Asp Gly 100 105 110 Val Gly Leu Ala Val Asp Ala Gln Ala Arg Pro Gln Lys Tyr Ile Met 115 120 125 Asp Asp Gln Asp Gly Leu Tyr Trp Ser Thr Asn Leu Leu Gln Ala Val 130 135 140 Asp Thr Arg Ala Gln Tyr Leu Asp Leu Asp Gln Thr Ile Gln Gly Asp 145 150 155 160 Gln Tyr Ala Met Ile Arg Asp Leu Tyr Leu Gln Arg Lys Ala Phe Gln 165 170 175 Ile Ala Glu Lys Lys Gly Asp Ser Ala Asp Val Ser Phe Ile Asp Asp 180 185 190 Asp Glu Ser Glu Asp Val Pro Glu Asp Asn Thr Asp Lys Thr Glu Lys 195 200 205 <210> SEQ ID NO 53 <211> LENGTH: 326 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 53 Met Val Leu Leu Asn Ser Lys Gly Pro Val Gly Gln Gly Gln Ser Asp 1 5 10 15 Leu Met Met Thr Ala Ile Tyr Leu Met Leu Leu Val Val Ile Pro Ser 20 25 30 Ile Ile Met Ala Leu Trp Phe Gly Trp Lys Tyr Arg Ala Ser Asn Lys 35 40 45 Asp Ala Asp Tyr Lys Pro Thr Trp Ala His Ser Thr Ala Ile Glu Val 50 55 60 Val Val Trp Gly Ile Pro Val Ile Ile Ile Gly Ile Leu Ala Trp Leu 65 70 75 80 Thr Trp Trp Gly Ser His Lys Tyr Asp Pro Tyr Arg Pro Leu Glu Ser 85 90 95 Asp Lys Ala Pro Leu Thr Ile Gln Val Ile Ala Glu Gln Phe Lys Trp 100 105 110 Ile Phe Ile Tyr Pro Glu Gln Asn Ile Ala Thr Val Asn Glu Val Arg 115 120 125 Phe Pro Glu Lys Thr Pro Leu Ser Phe Lys Ile Thr Ser Asn Phe Thr 130 135 140 Met Asn Ser Phe Phe Ile Pro Gln Leu Gly Gly Gln Ile Tyr Ala Met 145 150 155 160 Ala Gly Met Gln Thr His Leu His Leu Leu Ala Asn Glu Thr Gly Val 165 170 175 Tyr Arg Gly Phe Ser Ser Asn Tyr Ser Gly Tyr Gly Phe Ser Gln Met 180 185 190 Arg Phe Lys Ala His Ser Val Thr Glu Gln Gln Phe Asn Glu Trp Val 195 200 205 Ala Ala Val Lys Ala Gly Asn Gly Thr Thr Ile Asn Pro Glu Ala Val 210 215 220 Gln Lys Thr Thr Leu Asp Gln Ala Glu Leu Ala Thr Leu Arg Asp Gly 225 230 235 240 Asp Arg Ser Lys His Gln Ile Glu His Leu Val Asn Arg Ala Lys Ala 245 250 255 Ala Gly Asp Gln Glu Ala Leu Ala Lys Ala Glu Ala Met Lys Pro Phe 260 265 270 Pro Thr Lys Pro His Pro Val Thr Tyr Tyr Ser Ser Val Glu Pro Lys 275 280 285 Leu Phe Glu Thr Ile Ile Asn His Tyr Met Ser Asn Tyr His Gly Ala 290 295 300 Asp His Ser Ala Ala His Thr Ala Ala Glu Thr His Val Ala Ala Glu 305 310 315 320 His Ala Ala Gln Gly Glu 325 <210> SEQ ID NO 54 <211> LENGTH: 207 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 54 Met Ala Arg Tyr Ile Gly Pro Lys Cys Lys Leu Ser Arg Arg Glu Gly 1 5 10 15 Thr Asp Leu Gln Leu Lys Ser Gly Val Lys Pro Phe Asp Val Lys Thr 20 25 30 Lys Lys His Ala Lys Ala Pro Gly Gln His Gly Gln Ala Arg Gly Lys 35 40 45 Gln Ser Glu Tyr Ser Leu Gln Leu Arg Glu Lys Gln Lys Val Arg Arg 50 55 60 Met Tyr Gly Val Leu Glu Arg Gln Phe Ser Asn Tyr Tyr Lys Glu Ala 65 70 75 80 Ala Arg Val Lys Gly Ala Thr Gly Glu Asn Leu Leu Lys Leu Leu Glu 85 90 95 Ser Arg Leu Asp Asn Val Val Tyr Arg Met Gly Phe Gly Ser Thr Arg 100 105 110 Ala Glu Ala Arg Gln Leu Val Ser His Arg Ser Ile Thr Leu Asn Gly 115 120 125 Arg Arg Val Asn Ile Ala Ser Ile Gln Val Lys Ala Gly Asp Val Ile 130 135 140 Ala Val His Glu Gly Ala Lys Gln Gln Leu Arg Ile Lys Asn Ala Ile 145 150 155 160 Glu Leu Ala Ala Gln Arg Gly Ile Pro Ala Trp Met Asp Val Asp His 165 170 175 Ser Lys Leu Glu Gly Thr Phe Lys Ala Ala Pro Asp Arg Ser Asp Leu 180 185 190 Pro Ala Glu Ile Asn Glu Ser Leu Ile Val Glu Leu Tyr Ser Lys 195 200 205 <210> SEQ ID NO 55 <211> LENGTH: 355 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 55 Met Ala His Ala Glu Val Asn Ser Ser Ser Thr Gln Gln Val Asn Gly 1 5 10 15 Leu Ser Ser Gly Ala Gln Ala Glu Glu Asn Lys Asp Glu Asn Leu Leu 20 25 30 Asp Gln Ile Pro Arg Trp Ile Asp Ala Thr Pro Thr Ile Phe Pro Glu 35 40 45 Gln Ser Asn Glu Pro Ile Val Pro Pro Thr Glu Gln Thr Glu Asp Gln 50 55 60 Thr Trp Phe Asp Arg Lys Gln Lys Lys Ile Arg Asn Trp Ala Asp Arg 65 70 75 80 Thr Ser Gly Lys Ile Asp Asn Trp Phe Gly Glu Val Asp Pro Gln Lys

85 90 95 Pro Ala Ser Ala Thr Ile Arg Val Met Ile Asp Asn Tyr Trp Asn Glu 100 105 110 Tyr Asp Asn Tyr Glu Ile Lys Pro Arg Ile Arg Gly Lys Ile Lys Leu 115 120 125 Pro Thr Leu Glu Lys Arg Leu Ser Val Val Phe Gly Asp Asp Ser Leu 130 135 140 Asp Asp Glu Phe Asn Asn Ser Pro Ala Asn Ile Asn Gln Asn Pro Asn 145 150 155 160 Gln Asp Pro Asn Lys Lys Leu Asp Gly Lys Arg Thr Arg Asp Asp Asn 165 170 175 Ser Ser Ile Ala Leu Arg Trp Ser Asn Phe Ser Lys Lys Leu Pro Phe 180 185 190 Glu Thr Asp Ala Asp Leu Gly Ile Arg Ser Gly Asp Asp Ile Tyr Val 195 200 205 Arg Leu Lys Ala Ser Arg Asp Trp Gln Leu Arg Asn Asp Phe Lys Phe 210 215 220 Tyr Ala Glu Gln Ile Tyr Arg Tyr Gly Ile Asp Ser Glu Asn Tyr Leu 225 230 235 240 Arg Thr Asn Leu Glu Leu Thr His Ala Arg Pro Asn Gln Pro Ile Leu 245 250 255 Ser Asn Gln Phe Ser Leu Thr Tyr Ala Asp Asp Gln Asp Asp Asp Leu 260 265 270 Thr Trp Glu Asn Arg Leu Phe Arg Glu His Ser Phe Phe Ala Asn Asn 275 280 285 Arg Phe Asn Tyr Gly Ile Tyr Thr Gly Gly Tyr Tyr Asn Asp Asn Asp 290 295 300 Leu Arg Leu Asn Ser Trp Gly Pro Phe Val Ser Trp Arg Gln Pro Val 305 310 315 320 Leu Arg Glu Trp Phe Phe Val Gln Gly Asp Leu Asn Tyr Phe Asn Asp 325 330 335 His Arg Glu Asp Arg Asn His Tyr Val Ser Thr Phe Leu Arg Leu Glu 340 345 350 Ala Leu Phe 355 <210> SEQ ID NO 56 <211> LENGTH: 108 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 56 Met Ser Thr Leu Leu Val Ala Cys Asn Lys His Glu Asn Lys Thr Glu 1 5 10 15 Thr Thr Ser Asp Ala Ser Thr Pro Val Gln Thr Ala Gln Ser Asn Asn 20 25 30 Asn Glu Ala Val Asp Thr Ala His Thr Ala Glu Asn Ser Leu Asp Trp 35 40 45 Asp Gly Lys Tyr Lys Gly Thr Leu Pro Cys Ala Asp Cys Glu Gly Ile 50 55 60 Lys Thr Glu Leu Glu Leu Lys Asp Asp Lys Thr Tyr Glu Leu Thr Glu 65 70 75 80 Thr Tyr Leu Gly Lys Gly Asp Ala Asn Pro Phe Glu Pro Met Val Ser 85 90 95 Leu Leu Ser Ile Lys Thr Ile Leu Leu Leu Leu Pro 100 105 <210> SEQ ID NO 57 <211> LENGTH: 635 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 57 Met Arg Gly Phe Gly Ala Arg Ser Thr Phe Gly Val Arg Gly Ile Arg 1 5 10 15 Leu Tyr Val Asp Gly Ile Pro Ala Thr Met Pro Asp Gly Gln Gly Gln 20 25 30 Thr Ser Asn Ile Asp Leu Ser Ser Leu Asp His Val Glu Val Leu Thr 35 40 45 Gly Pro Phe Ser Ser Leu Tyr Gly Asn Ser Ser Gly Gly Thr Ile Leu 50 55 60 Thr Ser Thr Lys Glu Gly Gln Gly Lys Asp Ser Ile Glu Leu Ser Tyr 65 70 75 80 Ser Gly Gly Ser His Asp Lys Ser Arg Ala Gly Leu Val Leu Gln Gly 85 90 95 Gly Ala Lys Gly Ala Asn Glu Pro Ser Tyr Ile Ile Ser Ser Ser Tyr 100 105 110 Phe Asp Thr Asp Gly Tyr Arg Glu His Ser Gly Ala Glu Lys Val Leu 115 120 125 Asn Asn Ala Lys Leu Ser Trp Asn Leu Asp Asp Gly Ser Lys Ile Asn 130 135 140 Trp Val Thr Asn Tyr Val Lys Ile His Ala Asp Asp Pro Met Gly Leu 145 150 155 160 Glu Arg Lys Asp Trp Gln Ala Asn Pro Lys Gln Ile Ala Pro Tyr Val 165 170 175 Lys Lys Trp Gly Phe Asn Ala Arg Lys Asp Ile Glu Gln Thr Gln Thr 180 185 190 Gly Ile Thr Trp Phe Lys Pro Ile Asn Asp Gln His Glu Leu Tyr Ala 195 200 205 Met Ala Tyr Leu Gly Asn Arg Gln Val Thr Gln Tyr Gln Ser Ile Pro 210 215 220 Gln Gly Gln Val Val Val Glu Asn Gly Lys Pro Val Tyr Thr Gly Gln 225 230 235 240 Lys Ser Pro Lys His Ala Gly Gly Val Ile Asp Phe Glu Arg Asn Tyr 245 250 255 Tyr Gly Ala Asp Phe Arg Trp Thr Gly Lys Glu Leu Leu Pro Asn Thr 260 265 270 Thr Val Ser Ile Gly Val Ala Phe Asp Ala Met Asp Glu Glu Arg Lys 275 280 285 Gly Phe Glu Asn Phe Asn Ala Asp Gly Ile Tyr Gly Val Lys Gly Asn 290 295 300 Leu Arg Arg Asp Glu Asp Asn Thr Leu Trp Asn Ile Asp Pro Tyr Leu 305 310 315 320 Gln Ala Ser Trp Gln Phe Leu Pro Thr Trp Arg Leu Asp Thr Gly Val 325 330 335 Arg Tyr Ser Asn Val His Tyr Lys Ser Lys Asp His Phe Thr Ser Gly 340 345 350 Pro Asp Glu Tyr Gly Thr Val Asn Gly Asp Asp Ser Gly Lys Thr Asp 355 360 365 Tyr Glu Lys Val Leu Pro Ser Ala Ala Leu Ser Trp Gln Ile Leu Pro 370 375 380 Glu Leu Met Ala Tyr Val Ser Tyr Ala Lys Gly Phe Glu Thr Pro Thr 385 390 395 400 Phe Thr Glu Met Ala Tyr His Thr Asp Ile Ser Lys Ser Gly Phe Asn 405 410 415 Phe Gly Leu Lys Pro Ser Thr Ser Asp Thr Tyr Glu Thr Gly Leu Lys 420 425 430 Ser Gln Asn Leu Leu Gly Asp Phe Thr Leu Ala Val Phe Gln Thr Lys 435 440 445 Thr Lys Asn Asp Ile Val Ser Ala Gly Asn Leu Gly Gly Arg Ser Thr 450 455 460 Phe Arg Asn Ala Asp Lys Thr Leu Arg Glu Gly Val Glu Phe Ala Trp 465 470 475 480 Asn Lys Lys Leu Trp Arg Asp Leu Thr Ala Thr Ala Ser Tyr Thr Tyr 485 490 495 Leu Asp Ala Thr Phe Asp Ala Asn Val Pro Glu Lys Leu Asp Gln Asp 500 505 510 Asn Lys Val Leu Ala Ser Ala Ile Pro Thr Gly Asn Ala Ile Pro Gly 515 520 525 Ile Ala Lys Asn Gln Ala Tyr Ala Ser Leu Ala Trp Gln Pro Ser His 530 535 540 Gly Leu Tyr Gly Gly Val Asp Val Gln Tyr Met Asp Lys Val Tyr Val 545 550 555 560 Asn Asp Thr Asn Ser Asp Ala Ala Pro Ser Tyr Ser Val Thr Ser Ala 565 570 575 Asn Val Gly Tyr Ala Trp Val Met Gly Asp Trp Lys Val Asn Ser Phe 580 585 590 Ala Arg Val Asp Asn Leu Phe Asp Lys Lys Tyr Ala Gly Ser Val Ile 595 600 605 Val Asn Asp Gly Asn Ser Arg Tyr Phe Glu Pro Ala Asp Gly Arg Asn 610 615 620 Trp Ser Ala Gly Leu Arg Val Ile Lys Gln Phe 625 630 635 <210> SEQ ID NO 58 <211> LENGTH: 381 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 58 Met Thr Gly Ile Ser Ser Val Tyr Ala Gln Glu Gln Val Asp Pro Ala 1 5 10 15 Tyr Lys Pro Gly Asn Pro Ile Tyr Asp Lys Trp Asp Arg Phe Tyr Lys 20 25 30 Ile Glu Gln Ser Gln Pro Gln Glu Ala Glu Lys Ile Leu Val Glu Leu 35 40 45 Ser Lys Leu Thr Pro Thr Asp Ile Lys Val Trp Lys Ser Leu Thr Tyr 50 55 60 Leu Gln Ile Arg Leu Glu Lys Arg Glu Glu Ala Leu Gln Ser Leu Arg 65 70 75 80 Gln Ala Arg Asn Leu Ala Pro Gln Asp Asp Thr Leu Lys Leu Gln Glu 85 90 95 Ala Tyr Leu Leu Asn Gln Gln Lys Lys Asp Arg Glu Ala Leu Val Leu 100 105 110 Phe Lys Glu Leu Ser Ser Ser Ser Asp Pro Glu Ile Ala Ala Lys Ala 115 120 125 Thr Gln Ala Val Lys Asn Leu Ser Gly Gly Glu Val Lys Pro Tyr Phe 130 135 140 Lys Asp Ile Tyr Phe Ala Pro Ser Tyr Glu Ser Arg Tyr Asp Asp Val 145 150 155 160 Ile Phe Pro Leu Lys Met Arg Tyr Gly Lys Asn Ile Asp Asn Gly Arg 165 170 175

Ala Gln Val Tyr Ala Phe Leu Asn Leu Asn Arg Asp Thr Gln Ser Gln 180 185 190 Gly Gly Val Arg Pro Glu Ile Ile Asp Glu Asn Ala Ala Thr Leu Gly 195 200 205 Leu Gly Ala Asn Tyr Gln Pro Trp Thr Ser Ile Pro Val Arg Ala Tyr 210 215 220 Val Glu Val Gly Gly Ser Tyr Asp Leu Ile Asp Arg Asn Arg Lys Arg 225 230 235 240 Phe Arg Glu Ser Val Val Gly Gly Val Thr Gly Tyr Gln Glu Trp Tyr 245 250 255 Ser Gln Ser Asn Cys Asp His Ser Leu Cys Leu Asp Asn Tyr Phe Thr 260 265 270 Asp Leu Tyr Gly Asn Val Ala Thr Tyr Ser Arg Glu Asp Tyr Asn Val 275 280 285 Ile Gly Asp Leu Arg Leu Arg Thr Gly Leu Asn Leu Tyr Lys Gly Glu 290 295 300 Ser Gly Thr Val Gln Ala Tyr Val Lys Leu His Gly Leu Ala Asp Ser 305 310 315 320 Glu Asp Glu Tyr Tyr Asn Asn Leu Phe Glu Tyr Gly Pro Gly Ile Ser 325 330 335 Trp Gln Pro Phe Asn Tyr Gln Pro Ile Lys Leu Arg Val Glu Arg Leu 340 345 350 Tyr Gly Asn Tyr Phe Lys Asp Val Pro Val Asn Thr Lys Asp His Tyr 355 360 365 Asn Asn Thr Arg Val Glu Leu Val Phe Tyr Lys Asp Phe 370 375 380 <210> SEQ ID NO 59 <211> LENGTH: 212 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 59 Met Ala Ile Gly Leu Val Gly Arg Lys Cys Gly Met Thr Arg Ile Phe 1 5 10 15 Thr Asp Ala Gly Val Ser Val Pro Val Thr Val Ile Glu Val Asp Pro 20 25 30 Asn Arg Ile Thr Gln Ile Lys Thr Leu Glu Thr Asp Gly Tyr Gln Ala 35 40 45 Val Gln Val Thr Thr Gly Glu Arg Arg Glu Ser Arg Val Thr Asn Ala 50 55 60 Gln Lys Gly His Phe Ala Lys Ala Gly Val Ala Ala Gly Arg Leu Val 65 70 75 80 Lys Glu Phe Arg Val Thr Glu Ala Glu Leu Glu Gly Arg Glu Ile Gly 85 90 95 Gly Thr Ile Gly Val Asp Leu Phe Thr Val Gly Gln Val Val Asp Val 100 105 110 Thr Gly Gln Ser Lys Gly Lys Gly Phe Gln Gly Gly Val Lys Arg Trp 115 120 125 Asn Phe Arg Thr Gln Asp Ala Thr His Gly Asn Ser Val Ser His Arg 130 135 140 Val Leu Gly Ser Thr Gly Gln Asn Gln Thr Pro Gly Arg Val Phe Lys 145 150 155 160 Gly Lys Lys Met Ala Gly His Leu Gly Asp Glu Arg Val Thr Val Gln 165 170 175 Gly Leu Glu Ile Val Ser Ile Asp Ala Glu Arg Ser Val Leu Val Val 180 185 190 Lys Gly Ala Ile Pro Gly Ala Thr Gly Gly Asp Val Ile Val Arg Pro 195 200 205 Thr Ile Lys Ala 210 <210> SEQ ID NO 60 <211> LENGTH: 424 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 60 Met Leu Lys Ala Gln Lys Leu Thr Leu Ala Val Leu Ile Ser Ala Ala 1 5 10 15 Ile Ile Ser Ser Ala Gln Ala Ser Glu Gln Ser Glu Ala Lys Gly Phe 20 25 30 Val Glu Asp Ala Asn Gly Ser Ile Leu Phe Arg Thr Gly Tyr Ile Ser 35 40 45 Arg Asp Lys Lys Asp Gly Arg Ala Asp Asn Ser Ser Phe Ala Gln Thr 50 55 60 Ala Ile Val Asn Ile Asp Ser Gly Phe Thr Pro Gly Ile Val Gly Phe 65 70 75 80 Gly Val Gly Val Val Gly Asp Gly Ser Phe Lys Ile Gly Glu Asn Lys 85 90 95 Asn Ala Gly Asn Asn Met Ile Pro Gln His Asn Asp Gly Ser Ala Tyr 100 105 110 Asp His Trp Ala Arg Gly Gly Ala Asn Val Lys Ala Arg Phe Ser Asn 115 120 125 Thr Thr Val Arg Tyr Gly Thr Gln Val Leu Asp Leu Pro Val Leu Ala 130 135 140 Ser Asn Thr Ala Arg Leu Val Pro Glu Tyr Phe Thr Gly Thr Leu Leu 145 150 155 160 Thr Ser His Glu Ile Lys Asp Leu Glu Val Val Ala Gly Lys Phe Thr 165 170 175 Lys Asn Gln Tyr Ser Asp Gln Ile Ala Thr Asp Gln Asn Gly Leu Asp 180 185 190 Arg Ala Val Val Trp Gly Ala Lys Tyr Lys Phe Asp Asp Gln Ile Ser 195 200 205 Gly Ser Tyr Tyr Gly Val Asp Val Lys Asp Lys Leu Asp Arg His Tyr 210 215 220 Val Asn Val Asn Tyr Lys Gln Pro Leu Ala Asn Asp Ser Ser Leu Thr 225 230 235 240 Tyr Asp Phe Ser Gly Tyr His Thr Lys Phe Asp Lys Gly Ala Asn Leu 245 250 255 Ser Tyr Ala Thr Gly Pro Ala Asp Glu Asp Lys Thr Asn Asn Ile Trp 260 265 270 Ala Ile Ser Gly Thr Tyr Ala Thr Gly Pro His Ser Val Met Leu Ala 275 280 285 Tyr Gln Gln Asn Ser Gly Asn Ile Gly Tyr Asn Tyr Gly Val Asn Gln 290 295 300 Asp Gly Gly Gln Ser Val Tyr Leu Pro Asn Ser Tyr Leu Ser Asp Phe 305 310 315 320 Ile Gly Asn Asp Glu Lys Ser Ala Gln Ile Gln Tyr Ser Leu Asp Phe 325 330 335 Gly Lys Leu Gly Val Leu Pro Gly Leu Asn Trp Thr Thr Ala Tyr Val 340 345 350 Tyr Gly Trp Asp Ile Lys Thr Ser Asn Gly Ala Asp Asp Ser Asn Glu 355 360 365 Ser Glu Phe Phe Asn Gln Val Lys Tyr Thr Val Gln Ser Gly Phe Ala 370 375 380 Lys Gly Ser Ser Leu Arg Leu Arg Asn Ser Ile Tyr Arg Ala Asp Asn 385 390 395 400 Ala Tyr Thr Thr Asp Tyr Met Pro Asp Thr Asn Glu Trp Arg Ile Phe 405 410 415 Leu Asp Ile Pro Val Thr Leu Phe 420 <210> SEQ ID NO 61 <211> LENGTH: 641 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 61 Met Gln Leu Lys Asp Val Pro Gln Ile Val Asn Val Val Pro Lys Gln 1 5 10 15 Val Leu Arg Glu Gln Thr Val Thr Ser Met Gln Gly Ala Leu Gln Asn 20 25 30 Val Ala Gly Leu Ser Phe Ser Val Gly Asp Gly Gln Arg Asp Gln Val 35 40 45 Met Ile Arg Gly Phe Ser Ala Ile Thr Asp Asn Tyr Val Asp Gly Ile 50 55 60 Arg Asp Asp Ala Leu Tyr Phe Arg Asp Met Ser Asn Val Glu Arg Ile 65 70 75 80 Glu Val Leu Lys Gly Pro Ala Ser Val Leu Tyr Gly Arg Gly Ser Ala 85 90 95 Gly Gly Leu Val Asn Lys Ile Asn Lys Lys Pro Met Asp Gln Ser Leu 100 105 110 Arg Glu Val Ser Leu Ile Gly Ser Thr Thr Gly Gln Arg Arg Ala Glu 115 120 125 Val Asp Val Asn Glu Lys Val Ala Glu Asn Val Lys Val Arg Leu Thr 130 135 140 Gly Ala Val Glu Asp Ser Asp Gly Tyr Arg Asp Gln Ala Phe Leu Lys 145 150 155 160 Arg Gln Ala Val Ala Pro Ser Val Gln Trp Asp Ile Thr Asp Lys Thr 165 170 175 Lys Leu Leu Leu Gln Ala Asp Tyr Leu His Asp Asn Arg Leu Ala Asp 180 185 190 Gln Gly Phe Pro Thr Asp Pro Ile Thr Gly Lys Pro Val Lys Thr Asn 195 200 205 Pro Lys Thr Phe Tyr Gly Ala Leu Asn Gly Lys Glu Val Gly Asp Val 210 215 220 Asp Thr Glu Ile Ser Ser Gln Thr Ile Ser Leu Asp His Glu Phe Asn 225 230 235 240 Asp Asn Phe Lys Tyr His Gly Ala Val Arg His Tyr Asn Tyr Ser Leu 245 250 255 Asp Arg Gln Tyr Ser Val Asp Ser His Gln Lys Leu Pro Ala Asp Gln 260 265 270 Ile Gln Leu Thr Gln Asn Lys Arg Leu Arg Asn Glu Asp Gly Val Tyr 275 280 285 Val Gln Gln Glu Leu Ser Ala Val Phe Asn Thr Gly Phe Leu Lys His 290 295 300 Ser Thr Leu Ile Gly Ala Glu Tyr Ser Lys Gln His Lys Asp Glu Leu 305 310 315 320 Val Trp Ser Lys Ala Arg Gln Ile Thr Asn Ile Phe Asn Pro Gln Leu 325 330 335 Glu Asn Trp Ala Pro Leu Asp Thr Asn Val Asp Ala Asp Thr Asn Asn 340 345 350

Thr Asn Thr Phe Glu Asn Tyr Gly Val Tyr Leu Gln Asp Leu Met Thr 355 360 365 Val Thr Asp Gln Leu Lys Val Leu Val Gly Leu Arg Tyr Asp Asn Leu 370 375 380 Ser Gln Asp Arg Asp Asp Lys Thr Ser Lys Asn Val Asp Leu Asn Arg 385 390 395 400 Thr Asp Asn Thr Tyr Ser Pro Arg Ile Gly Val Val Tyr Gln Pro Val 405 410 415 Asn Asn Leu Ser Leu Tyr Thr Ser Tyr Asn Arg Ser Phe Gln Pro Leu 420 425 430 Ala Asp Ser Phe Val Phe Tyr Lys Asn Ser Asp Asp Leu Arg Pro Thr 435 440 445 Lys Thr Glu Asn Tyr Glu Ile Gly Ala Lys Trp Asp Val Asn Asp Gln 450 455 460 Leu Asn Val Thr Leu Ala Leu Phe Glu Met Ser Gln Thr Asn Ile Gln 465 470 475 480 Asn Lys Asp Pro Asn Asp Pro Lys Gly Leu Thr Ala Ile Leu Ala Gly 485 490 495 Glu Gln Lys Thr Lys Gly Val Glu Ile Ser Leu Ala Gly Gln Leu Thr 500 505 510 Asp Gln Leu Ser Val Leu Ala Gly Tyr Ser Tyr Met Asp Gly Lys Ile 515 520 525 Glu Lys Ser Ala Ile Gly Phe Thr Gly Asn His Ser Ala Leu Thr Pro 530 535 540 Asn Asn Thr Ala Asn Leu Trp Leu Lys Tyr Gln Ile Asn Asp His Trp 545 550 555 560 Tyr Ala Ala Val Gly Gly Arg Gly Glu Ser Ser Arg Phe Ser Ala Pro 565 570 575 Asp Asn Lys Asn Val Leu Pro Gly Tyr Ala Val Val Asn Ala Ala Leu 580 585 590 Gly Tyr Gln Ser Glu Arg Tyr Asp Val Asn Leu Asn Leu Asn Asn Leu 595 600 605 Phe Asp Arg Asp Tyr Phe Val Ser Gly His Ser Gly Ala Asn Asp Ser 610 615 620 Asn Met Met Gly Asp Pro Leu Asn Ala Gln Val Ala Leu Arg Tyr Arg 625 630 635 640 Phe <210> SEQ ID NO 62 <211> LENGTH: 209 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 62 Met Glu Glu Ala Val Gln Val Leu Asn Ser Leu Pro Ala Ala Lys Phe 1 5 10 15 Lys Glu Ser Leu Asp Ile Ser Val Asn Leu Gly Val Asp Pro Arg Lys 20 25 30 Ser Asp Gln Val Val Arg Gly Ala Thr Thr Leu Pro Ala Gly Thr Gly 35 40 45 Lys Thr Val Arg Val Ala Val Phe Ala Gln Gly Ala Gln Ala Glu Ala 50 55 60 Ala Lys Glu Ala Gly Ala Asp Val Val Gly Phe Asp Asp Leu Ala Glu 65 70 75 80 Ser Ile Gln Gly Gly Asn Leu Asp Phe Asp Val Val Ile Ala Ala Pro 85 90 95 Asp Ala Met Arg Val Val Gly Lys Leu Gly Thr Ile Leu Gly Pro Arg 100 105 110 Gly Leu Met Pro Asn Pro Lys Val Gly Thr Val Thr Pro Asp Val Ala 115 120 125 Gly Ala Val Lys Asn Ala Lys Ser Gly Gln Ala Arg Tyr Arg Val Asp 130 135 140 Lys Ala Gly Ile Ile His Ala Ala Ile Gly Gln Val Gly Phe Asp Ala 145 150 155 160 Ala Ala Ile Arg Gln Asn Val Glu Thr Leu Val Ala Asp Leu Lys Lys 165 170 175 Leu Lys Pro Ala Thr Ser Lys Gly Val Tyr Ile Lys Lys Ile Thr Leu 180 185 190 Ser Ser Thr Met Gly Pro Gly Leu Thr Val Asp Val Asn Asn Val Ser 195 200 205 Asn <210> SEQ ID NO 63 <211> LENGTH: 147 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 63 Met Tyr Pro Ala Pro Thr Val Asp Gln Leu Ala Ile Asp His Ala Pro 1 5 10 15 Lys Phe Glu Asn Lys Arg Gly Asn Arg Phe Ala Leu Pro Arg Pro Glu 20 25 30 Pro Leu Gln Thr Asp Thr Thr Ala Asp Ala Ser Ala Gln Thr Gly Ser 35 40 45 Ala Leu Gly Arg Pro Gln Leu Val Thr Asp Gly Asn Lys Asn Pro Leu 50 55 60 Leu Lys Ile Asp Gly Ser Thr Ala Glu Ile Trp Gln Tyr Thr Lys Ala 65 70 75 80 Thr Leu Ser Thr Leu Asn Tyr Asn Val Ile Ala Gln Gly Asn Asn Gln 85 90 95 Ala Thr Ile Lys Val Asn Asp Asn Thr Tyr Val Leu Lys Leu Thr Gly 100 105 110 Val Gly Ser Ser His Ser Leu Ala Leu Phe Asn Pro Asp Asn Thr Phe 115 120 125 Ala Ser Pro Asp Val Ala Ala Glu Val Leu Asn Gln Ile Tyr Gln Asn 130 135 140 Trp Pro Ala 145 <210> SEQ ID NO 64 <211> LENGTH: 201 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 64 Met Lys Val Ser Gly Leu Val Gly Thr Asn Leu Ser Asp Gly Tyr Thr 1 5 10 15 Met Lys Ala Gln Phe Asp Asn Val Asn Gly Leu Lys Pro Arg Ala Lys 20 25 30 Val Thr Met Ser Gly Val Thr Ile Gly Arg Val Asp Ser Ile Thr Leu 35 40 45 Asp Pro Val Thr Arg Leu Ala Thr Val Thr Phe Asp Leu Asp Gly Lys 50 55 60 Leu Thr Ser Phe Asn Ala Glu Gln Leu Lys Glu Val Gln Lys Asn Ala 65 70 75 80 Leu Asp Glu Leu Arg Tyr Ser Ser Asp Tyr Thr Gln Ala Thr Pro Ala 85 90 95 Gln Gln Lys Thr Met Glu Gln Gln Leu Ile Ser Asn Met Asn Ser Ile 100 105 110 Thr Ser Ile Asp Glu Asp Ala Tyr Ile Met Val Ala Thr Asn Gly Leu 115 120 125 Leu Gly Glu Lys Tyr Leu Lys Ile Val Pro Gly Gly Gly Leu Asn Tyr 130 135 140 Leu Lys Arg Gly Asp Thr Ile Ser Asn Thr Gln Gly Thr Met Asp Leu 145 150 155 160 Glu Asp Leu Ile Ser Lys Phe Ile Thr Gly Gly Gly Ala Gly Lys Val 165 170 175 Ala Ala Gly Ser Ser Ser Ala Glu Glu Lys Ala Pro Ala Ser Thr Asp 180 185 190 Ser Ser Ala Gln Pro Ser Phe Val Glu 195 200 <210> SEQ ID NO 65 <211> LENGTH: 183 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 65 Met Gly Val Ser Ser Phe Thr Phe Ala Gly Asn Trp Gln Val Lys Phe 1 5 10 15 Gly Gly Ser Val Ile Ala Pro Ser Glu Asp Thr Thr Thr Ala Leu Gly 20 25 30 Val Val Lys Ala Asp His Glu Tyr Ala Phe Thr Pro Ser Val Glu Tyr 35 40 45 Phe Phe Gly Gln Ser Pro Phe Ser Ala Glu Leu Leu Leu Ala Thr Pro 50 55 60 Val Asn His Asp Val Leu Leu Asp Gly Gln Lys Val Ala Arg Ile Lys 65 70 75 80 Gln Leu Pro Pro Thr Ile Thr Ala Lys Tyr His Phe Lys Asn Ser Thr 85 90 95 Arg Phe Thr Pro Tyr Ile Gly Ile Gly Ala Thr Ala Phe Ile Pro Trp 100 105 110 Asp Glu Gln Gly Val Ala Asp Lys Val Lys Glu Asp Phe Gly Val Ala 115 120 125 Gly Gln Ile Gly Phe Asn Phe Gln Pro Ala Asp Ala Lys Asn Trp Gly 130 135 140 Val Phe Val Asp Val Arg Tyr Ala Asp Ile Ser Pro Glu Val Thr Leu 145 150 155 160 Thr Asn Gly Ala Lys Phe Asp Leu Asp Ile Asn Pro Phe Val Tyr Thr 165 170 175 Leu Gly Tyr Ser Tyr Lys Phe 180 <210> SEQ ID NO 66 <211> LENGTH: 231 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 66 Met Met Lys Ile Leu Lys Leu Ser Phe Leu Ala Leu Gly Met Gly Leu 1 5 10 15 Ser Gly Phe Ala Gln Ala Asp Phe Ile Gly Val Lys Gly Asp Val Gly 20 25 30 Tyr Trp Phe Tyr Asp Gly Lys Ala Asn Met Ser Ser Gln Ser Pro Glu 35 40 45

Asp Gln Asp Leu Asp Arg Lys Gly Ser Ala Gln Leu Ser Leu Ala Phe 50 55 60 Glu His Pro Ile Pro Phe Ile Pro Asn Ala Lys Ile Arg Tyr Val Asn 65 70 75 80 Leu Asp Thr Gln Thr Lys Ser Glu Thr Leu Gly Gln Ala Asn Tyr Asn 85 90 95 Val Asp Leu Asp His Ser Asp Phe Ile Leu Tyr Tyr Glu Leu Leu Asp 100 105 110 Asn Ile Val Ser Val Asp Ala Gly Leu Gly Ala Thr Val Leu Asn Gly 115 120 125 Asp Ile Thr Ala Tyr Thr Gly Lys Arg Val Asp Ile Asp Lys Thr Tyr 130 135 140 Pro Ile Ala Tyr Leu Ser Gly Glu Val Lys Leu Pro Phe Thr Gly Leu 145 150 155 160 Ser Ala Lys Gly Glu Ala Thr Tyr Thr Asn Phe Asp Asp Ala Lys Ile 165 170 175 Thr Asp Ala Leu Val Glu Ala Lys Tyr Lys Phe Ala Asp Asn Leu Leu 180 185 190 Ile Asp Leu Gly Leu Thr Ala Gly Tyr Arg Ile Leu Asn Ile Asp Leu 195 200 205 Asp Asp Tyr Asp Asn Asn Asp Leu Lys Phe Glu Phe Lys Gly Pro Tyr 210 215 220 Val Gly Leu Glu Ala His Phe 225 230 <210> SEQ ID NO 67 <211> LENGTH: 142 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 67 Met Asp Asp Leu Lys Glu Asn Val Lys Glu Lys Gln Thr Ala Gly Lys 1 5 10 15 Glu Ala Val Ala Asp Lys Val Asp Glu Leu Lys Thr Lys Ala Ala Asp 20 25 30 Ala Lys Val Gln Gly Glu Lys Ala Leu Glu Asp Leu Lys Glu Asn Val 35 40 45 Lys Glu Lys Gln Ala Ala Ala Lys Glu Ala Val Glu Asp Lys Ala Ser 50 55 60 Asp Leu Lys Gly Lys Leu Asp Asp Ala Gln His Ser Leu Gln Asp Lys 65 70 75 80 Phe Asp His Leu Arg Thr Glu Ala Ala His Lys Leu Asp Asp Ala Lys 85 90 95 Ala Lys Ala Ala Glu Leu Lys Glu Glu Ala Ala Thr Lys Phe Asp Glu 100 105 110 Leu Lys Thr Gln Ala Thr Ala Lys Phe Asp Glu Leu Lys Lys Thr Ala 115 120 125 Thr Glu Lys Leu Asn Lys Leu Lys Asn His Asp Ser Ala Glu 130 135 140 <210> SEQ ID NO 68 <211> LENGTH: 344 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 68 Met Lys Ala Gln Val His Ala Gly Gly Arg Gly Lys Ala Gly Gly Val 1 5 10 15 Lys Val Ala Lys Ser Lys Glu Asp Val Ile Glu Phe Ala Asn Asn Ile 20 25 30 Ile Gly Thr Arg Leu Val Thr Tyr Gln Thr Asp Ala Asn Gly Gln Pro 35 40 45 Val Asn Ser Ile Ile Val Ala Glu Asp Val Tyr Pro Val Glu Arg Glu 50 55 60 Leu Tyr Leu Gly Ala Val Val Asp Arg Ser Ser Arg Arg Ile Thr Phe 65 70 75 80 Met Ala Ser Thr Glu Gly Gly Val Glu Ile Glu Lys Val Ala Glu Glu 85 90 95 Thr Pro Glu Lys Ile Ile Lys Val Glu Val Asp Pro Leu Val Gly Leu 100 105 110 Gln Pro Phe Gln Ala Arg Glu Val Ala Phe Ala Leu Gly Leu Lys Asp 115 120 125 Lys Gln Ile Gly Gln Phe Val Lys Ile Met Thr Ala Ala Tyr Gln Ala 130 135 140 Phe Val Glu Asn Asp Phe Ala Leu Phe Glu Ile Asn Pro Leu Ser Val 145 150 155 160 Arg Glu Asn Gly Glu Ile Leu Cys Val Asp Ala Lys Val Gly Ile Asp 165 170 175 Ser Asn Ala Leu Tyr Arg Leu Pro Lys Val Ala Ala Leu Arg Asp Lys 180 185 190 Ser Gln Glu Asn Glu Arg Glu Leu Lys Ala Ser Glu Phe Asp Leu Asn 195 200 205 Tyr Val Ala Leu Glu Gly Asn Ile Gly Cys Met Val Asn Gly Ala Gly 210 215 220 Leu Ala Met Ala Thr Met Asp Ile Ile Lys Leu Tyr Gly Gly Gln Pro 225 230 235 240 Ala Asn Phe Leu Asp Val Gly Gly Gly Ala Thr Lys Glu Arg Val Ile 245 250 255 Glu Ala Phe Lys Ile Ile Leu Ala Asp Thr Ser Val Gln Gly Val Leu 260 265 270 Ile Asn Ile Phe Gly Gly Ile Val Arg Cys Asp Met Ile Ala Glu Ala 275 280 285 Ile Ile Ala Ala Val Gln Glu Val Asn Val Thr Val Pro Val Val Val 290 295 300 Arg Leu Glu Gly Asn Asn Ala Glu Leu Gly Ala Lys Leu Leu Asp Glu 305 310 315 320 Ser Gly Leu Lys Leu Ile Ser Ala Asn Gly Leu Ser Asp Ala Ala Glu 325 330 335 Lys Val Val Ala Ala Val Lys Ala 340 <210> SEQ ID NO 69 <211> LENGTH: 415 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 69 Met Met Ser Ala Lys Leu Trp Ala Pro Ala Leu Thr Ala Cys Ala Leu 1 5 10 15 Ala Thr Ser Ile Ala Leu Val Gly Cys Ser Lys Gly Ser Asp Glu Lys 20 25 30 Gln Gln Ala Ala Ala Ala Gln Lys Met Pro Pro Ala Glu Val Gly Val 35 40 45 Ile Val Ala Gln Pro His Ser Val Glu Gln Ser Val Glu Leu Ser Gly 50 55 60 Arg Thr Ser Ala Tyr Gln Ile Ser Glu Val Arg Pro Gln Thr Ser Gly 65 70 75 80 Val Ile Leu Lys Arg Leu Phe Ala Glu Gly Ser Tyr Val Arg Glu Gly 85 90 95 Gln Ala Leu Tyr Glu Leu Asp Ser Arg Thr Asn Arg Ala Thr Leu Glu 100 105 110 Asn Ala Lys Ala Thr Leu Leu Gln Gln Gln Ala Asn Leu Ala Ser Leu 115 120 125 Arg Thr Lys Leu Asn Arg Tyr Lys Gln Leu Val Ser Ser Asn Ala Val 130 135 140 Ser Lys Gln Glu Tyr Asp Asp Leu Leu Gly Gln Val Asn Val Ala Glu 145 150 155 160 Ala Gln Val Ser Ala Ala Lys Ala Gln Val Thr Asn Ala Asn Val Asp 165 170 175 Leu Gly Tyr Ser Thr Ile Arg Ser Pro Ile Ser Gly Gln Ser Gly Arg 180 185 190 Ser Ser Val Thr Ala Gly Ala Leu Val Thr Ala Asn Gln Thr Asp Pro 195 200 205 Leu Val Thr Ile Gln Gln Leu Asp Pro Ile Tyr Val Asp Ile Asn Gln 210 215 220 Ser Ser Ala Glu Leu Leu Arg Leu Arg Gln Gln Leu Ser Lys Gly Ser 225 230 235 240 Leu Asn Asn Ser Asn Asn Thr Lys Val Lys Leu Lys Leu Glu Asp Gly 245 250 255 Ser Thr Tyr Pro Ile Glu Gly Gln Leu Ala Phe Ser Asp Ala Ser Ala 260 265 270 Asn Gln Asp Thr Gly Thr Ile Thr Leu Arg Ala Val Phe Ser Asn Pro 275 280 285 Asn His Leu Leu Leu Pro Gly Met Tyr Thr Thr Ala Gln Ile Val Gln 290 295 300 Gly Val Val Pro Asn Ala Tyr Leu Ile Pro Gln Ala Ala Ile Thr Arg 305 310 315 320 Leu Pro Thr Gly Gln Ala Val Ala Met Leu Val Asn Ala Lys Gly Ala 325 330 335 Val Glu Ser Arg Pro Val Glu Thr Ser Gly Val Gln Gly Gln Asn Trp 340 345 350 Ile Val Thr Asn Gly Leu Lys Ala Gly Asp Lys Val Ile Val Asp Gly 355 360 365 Val Ala Lys Val Lys Glu Gly Gln Glu Val Ser Ala Lys Pro Tyr Gln 370 375 380 Ala Gln Pro Ala Asn Pro Gln Gly Ala Ala Pro Asn Ala Thr Lys Pro 385 390 395 400 Ala Gln Ser Gly Lys Pro Gln Ala Glu Gln Lys Ala Ser Asn Ala 405 410 415 <210> SEQ ID NO 70 <211> LENGTH: 656 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 70 Met Asp Ser Ser Ser Ser Ala Thr Arg Ser Glu Ile Ala Leu Gln Asp 1 5 10 15 Thr Pro Gln Ser Val Ser Val Val Thr Gln Lys Val Ile Glu Asp Ile 20 25 30 Gly Ala Thr Arg Leu Val Glu Ala Leu Asp Leu Ala Gly Gly Val Thr 35 40 45 Arg Ala Asn Asn Phe Gly Gly Gln Gly Leu Thr Gly Phe Asn Val Arg 50 55 60 Gly Phe Thr Ser Gly Glu Phe Tyr Arg Asn Gly Phe Pro Ile Asn Arg

65 70 75 80 Gly Tyr Pro Asn Ala Pro Asp Ser Asn Thr Ile Glu Arg Val Asp Val 85 90 95 Leu Arg Gly Pro Ser Ser Ser Leu Tyr Gly Arg Gly Asp Pro Gly Gly 100 105 110 Thr Phe Asn Leu Ile Ser Lys Thr Pro Asn Ser Glu Gln Gln Thr Thr 115 120 125 Leu Gly Ala Gln Leu Asn Ser Glu Gly Leu Tyr Arg Thr Thr Val Asp 130 135 140 Thr Thr Gly Thr Ile Pro Asn Ala Glu Asn Ile Gly Tyr Arg Leu Asn 145 150 155 160 Val Ile Ala Glu Gly Gly Asp Ser Tyr Arg Asp His Val Glu Ser Lys 165 170 175 Arg Tyr Gly Ile Ala Pro Val Ile Gln Trp Gln Ala Thr Asp Ala Thr 180 185 190 Lys Val Thr Phe Glu Ala Asp Ile Leu Arg Asn Gln His Pro Leu Asp 195 200 205 Arg Gly His Thr Arg Tyr Pro Thr Gln Lys Ser Phe Asn Ser Ser Pro 210 215 220 Glu Thr Tyr Leu Trp Glu Thr Gly Lys Tyr Tyr Asn Arg Leu Tyr Asn 225 230 235 240 Asp Asn Asn Met Thr Gln Leu Arg Val Glu His Asp Leu Gly Asn Asp 245 250 255 Trp Lys Leu Asn Ala Gly Val Gln Tyr Leu Asn Gly Lys Leu His Gly 260 265 270 Tyr Ala Val Glu Ala Asn Gly Ile Gln Asn Asp Gly Glu Thr Leu Gly 275 280 285 Arg Asn Tyr Asn Tyr Arg Glu Leu Lys Trp Gln Asp Thr Asp Ala Gln 290 295 300 Ile Asn Leu Thr Gly Asn Phe Gln Leu Leu Gly Leu Ala His Thr Leu 305 310 315 320 Val Thr Gly Leu Glu Tyr Glu Asn Tyr Asp Tyr Lys Ser Tyr Ile Ile 325 330 335 Arg Ser Ser Glu Asp Ile Gly Ser Tyr Ser Ile Asn Ile Tyr Asn Pro 340 345 350 Val Leu Gly Gln Pro Leu Pro Glu Leu Asn Thr Val Thr Thr His Asp 355 360 365 Arg Glu Asn Leu Lys Thr Thr Ala Leu Phe Val Gln Asp Gln Leu Glu 370 375 380 Leu Asn Glu Arg Leu Ser Ala Leu Leu Gly Leu Arg Phe Glu His Tyr 385 390 395 400 Glu His Asp Tyr Gln Asp Leu Arg Pro Gly Lys Pro Asn Trp Asn Thr 405 410 415 Ser His Asp Ala Phe Ile Pro Arg Leu Gly Leu Val Tyr Lys Ala Ser 420 425 430 Asp Asp Leu Ser Leu Tyr Gly Asn Ala Ala Lys Ser Phe Lys Pro Asn 435 440 445 Thr Gly Ala Ser His Ser Gly Glu Gly Phe Asp Pro Glu Glu Gly Met 450 455 460 Ala Tyr Glu Leu Gly Phe Lys Trp Leu Ala Leu Asn Asn Met Leu Ser 465 470 475 480 Val Asp Ser Ala Ile Phe Tyr Ala Asn Lys Glu Asn Val Leu Thr Asn 485 490 495 Asp Pro Leu Phe Pro Asn Tyr Lys Val Ala Ala Gly Glu Val Arg Ser 500 505 510 Arg Gly Ile Glu Leu Asn Ile Ala Gly Gln Ile Thr Pro Ala Trp Lys 515 520 525 Ile Ile Gly Gly Tyr Ala Tyr Thr Asp Ala Glu Val Thr Lys Asp Asn 530 535 540 Thr Leu Gln Lys Gly Thr Ala Leu Ala Asn Ile Pro Lys Asn Ser Phe 545 550 555 560 Asn Leu Leu Asn Ile Tyr Glu Phe Gln Asp Gly Pro Leu Gln Gly Leu 565 570 575 Gly Leu Gly Ile Asn Gln Lys Tyr Ile Asp Lys Arg Ala Gly Gln Thr 580 585 590 Ala Asn Ser Thr Tyr Ile Met Lys Gly Tyr Ala Val Thr Asp Leu Val 595 600 605 Ser Tyr Tyr Gln Ala Thr Pro Lys Leu Arg Leu Asn Leu Asp Val Lys 610 615 620 Asn Ile Phe Asp Lys Val Tyr Asp Glu Ser Ala Phe Asn Leu Tyr Ala 625 630 635 640 Tyr Pro Gly Glu Ser Arg Thr Val Gln Leu Gly Met Ser Tyr Thr Phe 645 650 655 <210> SEQ ID NO 71 <211> LENGTH: 177 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 71 Met Asp Arg Met Arg Gly Glu Asp Asp Tyr Lys Ser Thr Tyr Phe Glu 1 5 10 15 Leu Ser Pro Arg Leu Ser Leu Gly Glu Val Ser Gly Lys Lys Leu Thr 20 25 30 Tyr Gly Pro Ile Lys Asp Val Leu Ile Ser Thr Thr Trp Glu Ser Asn 35 40 45 Thr Gln Asn Gly Asn Asn Phe Asp Asn Phe Leu Tyr Gly Phe Ala Val 50 55 60 Asp Leu Asp Ile Pro Tyr Phe Gln Tyr Ala Asn Leu Asn Phe Tyr Arg 65 70 75 80 Ala Asn Asn Glu Lys Thr Asp Asp Asp Tyr Gln Met Thr Phe Val Tyr 85 90 95 Gly Ile Pro Phe Lys Ile Ala Ser Glu Asp Phe Leu Val Asp Gly Phe 100 105 110 Leu Asp Trp Ser Thr Ala Glu Asp Asp His Ala Ser Glu Leu Asn Trp 115 120 125 Thr Thr Gln Trp Lys Trp Asn Val Gly Lys His Ile Ser Pro Asp Thr 130 135 140 Arg Leu Tyr Leu Gly Ile Glu His Ser Val Trp Asn Asn Lys Phe Gly 145 150 155 160 Ile Lys Gly Ala Asp Glu Asn Asn Val Ser Ala Leu Val Lys Tyr His 165 170 175 Phe <210> SEQ ID NO 72 <211> LENGTH: 581 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 72 Met Tyr Ala Asn Lys Asn Gln Lys Ser Glu Val Thr Tyr Ala Gly Tyr 1 5 10 15 Phe Leu Ser Glu Asn Gly Asn Asn Asn Leu Lys Glu Glu Leu Lys Ala 20 25 30 Asp Ile Ser Ala Leu Phe Ile Pro Thr Gln Asp Asn Gln Ser Ile Arg 35 40 45 Cys Lys Phe Pro Ala Arg Ser Gln Trp Leu Ile Gln Gln Leu Gly Ile 50 55 60 Gln Glu Asn Glu Leu Pro Gln Val Lys Cys Ser Glu Phe Glu Asn Trp 65 70 75 80 Ile Gly Gln Ile Lys Pro Tyr Lys Ala Thr Leu Ile Tyr Ala Thr Asp 85 90 95 Phe Met Gly Asn Pro Ser Ser Met Phe Gly His Thr Leu Leu Arg Leu 100 105 110 Asp Pro Lys Asp Gln Gln Gln Leu Asn Leu Val Ser Tyr Ala Val Asn 115 120 125 Tyr Ala Ala Thr Val Ala Gly Asn Asp Asn Trp Ser Tyr Ala Trp Lys 130 135 140 Gly Leu Thr Gly Gln Tyr Pro Gly Glu Tyr Ser Leu Met Pro Tyr Tyr 145 150 155 160 Arg Lys Val Lys Glu Tyr Gly Asp Phe Glu Ser Arg Asp Leu Trp Glu 165 170 175 Tyr Glu Leu Asn Leu Ser Pro Glu Glu Thr Arg Phe Leu Val Ser His 180 185 190 Ile Trp Glu Met Gln His Val Ser Phe Pro Tyr Tyr Phe Val Ser Asp 195 200 205 Asn Cys Ala Tyr Arg Leu Leu Gly Leu Val Asp Leu Val Lys Pro Glu 210 215 220 Ser His Leu Gln Glu Lys Phe Asn Tyr Ala Ser Ile Pro Met Glu Thr 225 230 235 240 Ile Lys Ala Met Gln Gln Gln Gly Leu Thr Lys Ala Pro Val Tyr Arg 245 250 255 Pro Ala Leu Glu Thr Gln Leu Leu Ala Gln Ala His Gln His Gly Ala 260 265 270 Ser Leu Ala Lys Val Ala His Gln Leu Ala Met Lys Pro Ile Lys Glu 275 280 285 Ser Ser Glu Thr Leu Lys Ser Phe Ser Pro Ser Asp Gln Ala Lys Ile 290 295 300 Leu Glu Met Ala Tyr Asp Asp Leu Tyr Leu Gln Phe Ile Gly Arg Lys 305 310 315 320 Val Glu Glu Ser Phe Ala Gln Pro Gln Leu Arg Gln Leu Leu Ala Leu 325 330 335 Arg Ser Gln Ile Asp Leu Asp Lys Gln Arg Gln Glu Pro Lys Arg Pro 340 345 350 Ser Thr Glu Pro Thr Gln Gly His Asn Ala Arg Asn Val Ser Leu Lys 355 360 365 Leu Gly Glu Val Gln Gly Asp Lys Phe Ile Glu Ile Gly His Arg Gln 370 375 380 Ala Tyr His Asp Leu Ile Asp Pro Gln Gly Gly Tyr Arg Ala Gly Thr 385 390 395 400 Gln Leu Leu Phe Leu Asn Gly Asn Ala Gln Trp Arg Asp Asp His Leu 405 410 415 Lys Leu Glu Arg Leu Asp Leu Leu Glu Val Asn Ser Tyr Asn Pro Ile 420 425 430 Gln Pro Phe Lys Thr Pro Leu Thr Trp Gly Phe Asn Leu Gly Trp Arg 435 440 445 Gln Glu Ala Val His Asp Gly Val Tyr Ser Asp Glu Lys Gln His Gly 450 455 460 Val Ala Ser Phe Asn Ala Gln Val Gly Tyr Ser Leu Ala Asp Tyr Glu 465 470 475 480 Arg Lys His Ile Cys Tyr Gly Gln Val Gln Thr Tyr Val Gln Ala Gly 485 490 495

Ser Asn Leu Asp Lys Gly Trp Arg Val Gly Val Gly Pro Thr Leu Gly 500 505 510 Cys Met Asn Gln Trp Leu Glu Lys Phe Asn Thr Val Val Gln Val Glu 515 520 525 Leu Pro Tyr Trp Glu Asp Gln Asn Gln Trp Asn Leu Arg Leu Asn Thr 530 535 540 Gln Trp Gln Tyr Ala Ile Asn Ser Asn Asn Ala Ile Arg Phe Asn Trp 545 550 555 560 Asp Tyr Glu Lys Gln Asn His Leu Asp Trp Met Lys Ser Ser Leu Gly 565 570 575 Tyr Val Trp Phe Phe 580 <210> SEQ ID NO 73 <211> LENGTH: 205 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 73 Met Arg Gly Asn Asn Val Asn Leu Lys Thr Val Ser Gly Ser Ala Val 1 5 10 15 Glu Leu Ser Glu Val Ala Phe Gly Arg Glu Phe Asn Glu Ala Leu Val 20 25 30 His Gln Val Val Thr Ala Tyr Leu Ala Gly Gly Arg Gln Gly Thr Arg 35 40 45 Ala Gln Lys Ser Arg Ala Glu Val Ser Gly Gly Gly Lys Lys Pro Phe 50 55 60 Arg Gln Lys Gly Thr Gly Arg Ala Arg Ala Gly Ser Ile Arg Ser Pro 65 70 75 80 Ile Trp Val Gly Gly Gly Lys Thr Phe Ala Ala Arg Pro Gln Asp Trp 85 90 95 Ser Gln Lys Val Asn Arg Lys Met Tyr Arg Gly Ala Met Gln Cys Ile 100 105 110 Leu Ala Glu Leu Val Arg Gln Asp Arg Leu Val Leu Val Glu Glu Phe 115 120 125 Ala Val Ala Ala Pro Lys Thr Lys Glu Leu Leu Ala Lys Leu Asn Asp 130 135 140 Leu Asn Ala Ala Arg Ala Leu Ile Val Thr Asp Ala Val Asp Glu Asn 145 150 155 160 Leu Tyr Leu Ala Ala Arg Asn Leu Pro His Val Asp Val Val Asp Ala 165 170 175 Thr Ala Ile Asp Pro Val Ser Leu Ile Ala Phe Asp Lys Val Val Met 180 185 190 Ser Val Ala Ala Ala Lys Lys Ile Glu Val Glu Leu Gly 195 200 205 <210> SEQ ID NO 74 <211> LENGTH: 152 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 74 Met Lys Gly Ser Lys Gly Thr Leu Ser Phe Asn Leu His Ala Leu Val 1 5 10 15 Glu Leu Lys Gln Glu Glu Gly Lys Leu Gln Leu Ala Pro Ala Lys Glu 20 25 30 Ser Lys Asp Ala Trp Met Gln Ala Gly Thr Ala Arg Ala Val Leu Asn 35 40 45 Asn Leu Val Lys Gly Val Ser Glu Gly Phe Glu Arg Lys Leu Gln Leu 50 55 60 Val Gly Val Gly Tyr Lys Ala Ala Val Lys Gly Thr Val Val Asn Leu 65 70 75 80 Asn Leu Gly Tyr Ser His Pro Ile Asp Tyr Ala Leu Pro Glu Gly Val 85 90 95 Thr Ala Glu Thr Pro Thr Ala Thr Glu Ile Ile Leu Lys Ser Ala Asn 100 105 110 Lys Gln Leu Leu Gly Gln Val Ala Ala Glu Ile Arg Ala Tyr Arg Ser 115 120 125 Pro Glu Pro Tyr Lys Gly Lys Gly Val Arg Tyr Ser Asp Glu Val Ile 130 135 140 Leu Arg Lys Glu Ala Lys Lys Lys 145 150 <210> SEQ ID NO 75 <211> LENGTH: 221 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 75 Met Thr Asn Leu Thr Asp Tyr Val Val Leu Asn Thr Ser Val Ala Ser 1 5 10 15 Gly Glu Gln Asp Val Asn Ala Phe Gln Ser Phe Asn Tyr Leu Ala Ala 20 25 30 Tyr Asn Ala Ser Asn Lys Ala Lys Val Ala Ala Val Ala Thr Thr Tyr 35 40 45 Leu Glu Pro Met Gly Ile Tyr Ala Asn Lys Val Lys Thr Val Asp Glu 50 55 60 Phe Pro Gln Gly Ala Thr Ile Ala Ile Pro Asn Asp Thr Ala Asn Glu 65 70 75 80 Ala Arg Ala Leu Thr Leu Leu Gln Ser Ala Lys Leu Ile Lys Leu Lys 85 90 95 Pro Asp Phe Asp Pro Val Lys Gly Thr Thr Asn Asp Val Val Glu Asn 100 105 110 Pro Lys Asn Leu Gln Leu Lys Pro Ile Gln Met Thr Thr Ala Val Arg 115 120 125 Val Lys Asn Asp Val Asp Ala Ile Val Leu Gly Asn Thr Leu Ala Leu 130 135 140 Glu Gly Gly Leu Asn Val Met Lys Asp Ala Ile Phe Arg Glu Pro Ile 145 150 155 160 Asp Gln Ser Thr Lys Leu Tyr Val Asn Leu Leu Gly Val Ala Glu Ala 165 170 175 Asn Lys Asn Asp Pro Ile Tyr Thr Lys Leu Gly Glu Leu Tyr His Leu 180 185 190 Pro Lys Val Gln Lys Phe Val Asn Glu Lys Phe Gly Gly Thr Lys Val 195 200 205 Glu Val Asn Lys Pro Val Ser Glu Phe Ala Asp Ile Lys 210 215 220 <210> SEQ ID NO 76 <211> LENGTH: 99 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 76 Met Ala Thr Ala Val Arg Val Lys Asp Glu Val Asp Ala Ile Val Leu 1 5 10 15 Gly Asn Thr Leu Ala Met Glu Gly Gly Leu Asn Val Leu Lys Asp Ser 20 25 30 Ile Tyr Tyr Glu Pro Val Asp Gln Ser Thr Lys Leu Asn Val Asn Ile 35 40 45 Leu Ala Thr Ala Glu Ser Arg Lys Asp Asp Pro Val Leu Gln Lys Val 50 55 60 Gly Gln Leu Tyr His Thr Glu Ala Val Lys Lys Tyr Val Glu Gln His 65 70 75 80 Phe Gly Gly Thr Lys Val Asp Val Asn Gln Pro Ile Ser Tyr Leu Thr 85 90 95 Gln Ala Lys <210> SEQ ID NO 77 <211> LENGTH: 169 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 77 Met Val Asn Glu Thr Met Lys His Gln Phe Lys Phe Asn Pro Leu Ala 1 5 10 15 Thr Ala Ile Phe Thr Leu Leu Cys Ser Gly Ser Ile Gln Ser Ser Tyr 20 25 30 Ala Glu Ser Ala Gly Val Val Ser Asn Ile Asp Asn Asn Gln Leu Lys 35 40 45 Ala Ser Ile Lys Glu Ala Tyr Pro Gly Gln Glu Phe Phe Gln Gln Tyr 50 55 60 Tyr Val Asp Lys Ser Ala Pro Glu Ala Gln Leu Arg Asn Asn Lys Tyr 65 70 75 80 Leu Ser Ser Ala Phe Cys Gln Gly Thr Trp Ile Thr Pro Ile Asn Pro 85 90 95 Glu Thr Lys Ala Leu Asp Ala Asp Lys Ala Thr Ser Val Val Thr Ala 100 105 110 Asp Tyr Gly His Tyr Asn Pro Ala Gly Asp Ser Val Leu Glu Gly Asn 115 120 125 Val Val Ile Asp Gln Glu Gly Arg Thr Val Arg Ala Asp Lys Val Thr 130 135 140 Ile Asp Lys Thr Gln Thr Phe Ala His Ala Gln Gly Arg Val Gln Leu 145 150 155 160 Ala Gln Gly Gly Leu Leu Ser Thr Lys 165 <210> SEQ ID NO 78 <211> LENGTH: 236 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 78 Met Ser Arg Gly Thr Arg Thr Phe Glu Ile Tyr Arg Tyr Asp Pro Asp 1 5 10 15 Lys Asp Lys Ala Pro Tyr Met Gln Thr Phe Lys Leu Glu Leu Thr Asp 20 25 30 Lys His Arg Met Leu Leu Asp Ala Leu Leu Ala Leu Lys Val Gln Asp 35 40 45 Glu Thr Leu Thr Phe Arg Arg Ser Cys Arg Glu Gly Ile Cys Gly Ser 50 55 60 Asp Gly Val Asn Ile Asn Gly Lys Asn Gly Leu Ala Cys Leu Trp Asn 65 70 75 80 Leu Asn Asp Leu Pro Glu Lys Ile Val Ile Arg Pro Leu Pro Gly Leu 85 90 95 Pro Val Ile Lys Asp Leu Val Val Asp Met Asn Gln Phe Tyr Asp Gln 100 105 110 Tyr Asp Lys Ile Gln Pro Phe Leu Ile Asn Asn Gln Pro Ala Pro Pro 115 120 125

Lys Glu Arg Leu Gln Ser Pro Glu Glu Arg Glu His Leu Asn Gly Leu 130 135 140 Tyr Glu Cys Ile Leu Cys Ala Cys Cys Ser Thr Ser Cys Pro Ser Phe 145 150 155 160 Trp Trp Asn Pro Asp Lys Phe Leu Gly Pro Ser Ala Leu Leu Asn Ala 165 170 175 Tyr Arg Phe Ile Ile Asp Ser Arg Asp Thr Ala Thr Gln Asp Arg Leu 180 185 190 Ser Arg Leu Asp Asp Pro Phe Ser Leu Phe Arg Cys Lys Gly Ile Met 195 200 205 Asn Cys Val Ser Val Cys Pro Lys Gly Leu Asn Pro Thr Lys Ala Ile 210 215 220 Gly His Ile Arg Asn Met Leu Phe Asp Gln Ala Gly 225 230 235 <210> SEQ ID NO 79 <211> LENGTH: 300 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 79 Met Leu Gly Lys Asp Gln Pro Val Ile Leu Gln Leu Leu Glu Val Pro 1 5 10 15 Val Glu Lys Ala Gln Gln Ala Leu Lys Gly Val Met Met Glu Leu Asp 20 25 30 Asp Cys Ala Phe Pro Leu Leu Ala Gly Met Ile Gly Thr Asp Asp Pro 35 40 45 Lys Val Ala Phe Lys Asp Ala Asp Tyr Ala Leu Leu Val Gly Ser Arg 50 55 60 Pro Arg Gly Pro Gly Met Glu Arg Ala Asp Leu Leu Lys Val Asn Gly 65 70 75 80 Glu Ile Phe Ile Gly Gln Gly Gln Ala Leu Asn Glu Val Ala Ser Arg 85 90 95 Asp Val Lys Val Leu Val Val Gly Asn Pro Ala Asn Thr Asn Ala Tyr 100 105 110 Ile Ala Met Lys Ser Ala Pro Asp Leu Pro Ala Lys Asn Phe Thr Ala 115 120 125 Met Leu Arg Leu Asp His Asn Arg Ala Leu Thr Gln Val Ala Gln Lys 130 135 140 Ala Gly Val Ala Val Ala Asp Ile Glu Lys Leu Thr Val Trp Gly Asn 145 150 155 160 His Ser Pro Thr Met Tyr Ala Asp Tyr Arg Phe Ala Thr Ala Asn Gly 165 170 175 Glu Ser Leu Lys Asp Lys Ile Asn Asp Pro Ala Trp Asn Lys Asp Val 180 185 190 Phe Leu Pro Thr Val Gly Lys Arg Gly Ala Ala Ile Ile Glu Ala Arg 195 200 205 Gly Leu Ser Ser Ala Ala Ser Ala Ala Asn Ala Ala Ile Asp His Met 210 215 220 Arg Asp Trp Ala Leu Gly Thr Asn Gly Lys Trp Val Thr Met Gly Val 225 230 235 240 Pro Ser Asp Gly Ser Tyr Gly Ile Pro Glu Gly Val Met Phe Gly Phe 245 250 255 Pro Val Thr Thr Glu Asn Gly Glu Tyr Lys Ile Val Gln Gly Leu Glu 260 265 270 Ile Asp Glu Phe Ser Arg Glu Arg Ile Asn Phe Thr Leu Asn Glu Leu 275 280 285 Glu Glu Glu Arg Ala Ala Ile Ala Asp Met Val Lys 290 295 300 <210> SEQ ID NO 80 <211> LENGTH: 373 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 80 Met Gly Glu Pro Val Ser Arg Asp Glu Val Ile Cys Asp Ile Glu Thr 1 5 10 15 Asp Lys Val Val Leu Glu Val Val Ala Pro Ala Asp Gly Ser Leu Val 20 25 30 Ala Ile Ile Lys Gly Glu Gly Asp Thr Val Leu Ser Asp Glu Val Ile 35 40 45 Ala Gln Phe Glu Ala Gly Ala Gly Ala Ala Ala Ala Ala Pro Ala Ala 50 55 60 Val Glu Gln Ala Val Ala Gln Thr Gln Ala Gly Ala Ala Pro Val Val 65 70 75 80 Glu Arg Asn Glu Thr Val Ser Asp Gln Ala Pro Ala Val Arg Lys Ala 85 90 95 Leu Thr Glu Ser Gly Ile Ala Ala Ser Asp Val Gln Gly Thr Gly Arg 100 105 110 Gly Gly Arg Ile Thr Lys Glu Asp Val Ala Asn His Gln Ala Lys Pro 115 120 125 Ala Ala Asn Val Thr Pro Leu Ser Val Ala Val Gly Glu Arg Ile Glu 130 135 140 Lys Arg Val Pro Met Thr Arg Leu Arg Lys Arg Val Ala Glu Arg Leu 145 150 155 160 Leu Ala Ala Thr Gln Glu Thr Ala Met Leu Thr Thr Phe Asn Glu Val 165 170 175 Asn Met Lys Pro Ile Met Glu Leu Arg Lys Gln Tyr Lys Asp Ala Phe 180 185 190 Glu Lys Arg His Gly Ala Arg Leu Gly Phe Met Ser Phe Phe Val Lys 195 200 205 Ala Ala Thr Glu Ala Leu Lys Arg Tyr Pro Ala Val Asn Ala Ser Ile 210 215 220 Asp Gly Asp Asp Ile Val Tyr His Gly Tyr Tyr Asp Ile Gly Val Ala 225 230 235 240 Val Ser Ser Asp Arg Gly Leu Val Val Pro Val Leu Arg Asp Thr Asp 245 250 255 Arg Met Ser Tyr Ala Glu Val Glu Ala Gly Ile Ala Ala Tyr Ala Ala 260 265 270 Lys Ala Arg Asp Gly Lys Leu Ser Ile Glu Glu Met Thr Gly Gly Thr 275 280 285 Phe Thr Ile Thr Asn Gly Gly Thr Phe Gly Ser Leu Leu Ser Thr Pro 290 295 300 Ile Leu Asn Gln Pro Gln Thr Gly Ile Leu Gly Met His Lys Ile Gln 305 310 315 320 Glu Arg Pro Met Ala Val Asn Gly Gln Val Glu Ile Leu Pro Met Met 325 330 335 Tyr Leu Ala Leu Ser Tyr Asp His Arg Met Ile Asp Gly Lys Glu Ala 340 345 350 Val Gly Phe Leu Val Ala Ile Lys Glu Leu Leu Glu Glu Pro Ala Lys 355 360 365 Leu Ile Leu Asp Leu 370 <210> SEQ ID NO 81 <211> LENGTH: 468 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 81 Met Ser Phe Ser Met Thr Lys Leu Ser Ala Ala Leu Leu Leu Thr Ser 1 5 10 15 Ser Leu Val Gly Cys Ala Ala Val Val Lys Thr Pro Tyr Gln Ala Pro 20 25 30 Ala Val Gln Val Pro Gly Ser Phe Gln Tyr Asp Lys Ala Lys Ala Lys 35 40 45 Thr Ala Ser Val Glu Gln Tyr Ser Asp Arg Trp Trp Thr Leu Phe Gly 50 55 60 Asp Thr Gln Leu Asn Gln Leu Val Thr Asn Val Leu Glu Arg Asn Ser 65 70 75 80 Asp Leu Ala Val Ala Gly Ile Thr Leu Gln Gln Ala Arg Leu Gln Ala 85 90 95 Asp Leu Thr Ala Asn Lys Gln Gly Leu Arg Thr Ser Ser Ser Val Ser 100 105 110 Thr Gly His Ser Phe Asp Leu Asn Ser Gly Asp Asp Ser Ala Lys Gly 115 120 125 Leu Ser Met Ser Ala Gly Val Ser Tyr Glu Leu Asp Leu Phe Gly Lys 130 135 140 Leu Ala Arg Gln Thr Glu Ala Ser Lys Trp Glu Ala Leu Ala Thr Glu 145 150 155 160 Gln Asp Leu Gln Ala Thr Gly Gln Ser Leu Ile Ala Thr Thr Ala Lys 165 170 175 Leu Tyr Trp Gln Leu Gly Tyr Leu Asn Glu Arg Tyr Ala Thr Ala Gln 180 185 190 Gln Ser Leu Ala Thr Ser Gln Lys Leu Tyr Gln Leu Val Gln Thr Gln 195 200 205 Tyr Lys Ala Gly Ala Val Ser Gly Leu Asp Leu Thr Gln Ala Glu Gln 210 215 220 Ser Val Gln Ser Gln Lys Ala Ser Leu Ser Gln Ile Glu Gln Gln Leu 225 230 235 240 Val Glu Thr Arg Thr Ala Ile Ala Val Leu Leu His Glu Pro Leu Gln 245 250 255 Gln Leu Asn Ile Gln Glu Pro Gln Arg Leu Pro Arg Thr Ala Leu Pro 260 265 270 Ala Ile Gly Ala Gly Leu Pro Ala Asp Ile Leu Ser Arg Arg Pro Asp 275 280 285 Leu Gln Ala Ala Glu Leu Arg Leu Arg Lys Ala Leu Ala Thr Lys Asp 290 295 300 Ala Thr Lys Ala Ser Tyr Tyr Pro Ser Ile Ser Leu Thr Ser Ser Leu 305 310 315 320 Gly Ser Ser Ser Thr Ser Leu Thr Glu Leu Leu Arg Asn Pro Ala Leu 325 330 335 Thr Leu Gly Ala Ser Leu Ser Leu Pro Phe Leu Gln Tyr Asn Asp Met 340 345 350 Lys Lys Asp Ile Ala Ile Ser Asn Leu Asp Tyr Glu Lys Ala Ile Ile 355 360 365 Gln Tyr Arg Gln Thr Leu Tyr Gln Ala Phe Ala Asp Val Glu Asn Ala 370 375 380 Leu Ser Ser Arg Thr Glu Leu Asp Lys Gln Val Ala Leu Gln Glu Arg 385 390 395 400 Asn Val Glu Leu Ala Glu Lys Thr Glu Arg Leu Thr Glu Val Arg Tyr

405 410 415 Arg Tyr Gly Ala Val Ala Leu Lys Thr Leu Leu Asp Ala Gln Gln Thr 420 425 430 Thr Arg Thr Ala Arg Leu Ser Leu Val Glu Thr Lys Gln Ser Gln Tyr 435 440 445 Asn Ala Tyr Val Thr Leu Met Gln Ala Leu Gly Gly Ser Pro Val Lys 450 455 460 Glu Leu Pro Gln 465 <210> SEQ ID NO 82 <211> LENGTH: 358 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 82 Met Ala Tyr Ala Asp Thr Leu Ala Pro Val Lys Pro Ala Ser Val Asp 1 5 10 15 Ala Cys Val Ala Leu Ala Ser Asn Ala Asp Arg Leu Ala Cys Tyr Asp 20 25 30 Ala Val Phe Lys Pro Ser Ala Leu Pro Val Val Gln Ala Ala Val Val 35 40 45 Pro Glu Pro Val Lys Lys Ile Asp Lys Pro Val Val Gln Pro Glu Thr 50 55 60 Phe Lys Glu Lys Val Val Asp Lys Val Ser Asn Ile Lys Val Ile Gly 65 70 75 80 Lys Ala Pro Thr Leu Glu Pro Thr Thr Ser Leu Leu Asp Gln Arg Trp 85 90 95 Glu Leu Ser Glu Lys Ser Lys Leu Gly Val Trp Asn Ile Arg Ala Tyr 100 105 110 Gln Pro Val Tyr Leu Leu Pro Val Phe Trp Thr Ser Asp Lys Asn Glu 115 120 125 Phe Pro Ser Ser Pro Asn Pro Asn Asn Thr Val Thr Glu Ala Gln Asn 130 135 140 Leu Lys Ser Thr Glu Ser Lys Phe Gln Ile Ser Leu Lys Thr Lys Ala 145 150 155 160 Trp Glu Asn Ile Phe Gly Asn Asn Gly Asp Leu Trp Val Gly Tyr Thr 165 170 175 Gln Ser Ser Arg Trp Gln Thr Phe Asn Ala Glu Glu Ser Arg Pro Phe 180 185 190 Arg Glu Thr Asn Tyr Glu Pro Glu Ala Ser Leu Met Phe Arg Thr Asn 195 200 205 Tyr Glu Leu Leu Gly Leu Asp Gly Arg Leu Leu Gly Val Thr Leu Asn 210 215 220 His Gln Ser Asn Gly Arg Ser Asp Pro Leu Ser Arg Ser Trp Asn Arg 225 230 235 240 Val Ile Phe Asn Val Gly Leu Glu Arg Gly Asn Phe Ala Leu Met Leu 245 250 255 Arg Pro Trp Ile Arg Leu Glu Glu Asp Ser Lys Asp Asp Asn Asn Pro 260 265 270 Asp Met Glu Asp Tyr Ile Gly Arg Gly Asp Leu Thr Ala Phe Tyr Lys 275 280 285 Trp Lys Gln Asn Asp Phe Ser Leu Met Leu Arg His Ser Leu Lys Gly 290 295 300 Gly Asp Asp Ser His Gly Ala Val Gln Phe Asp Trp Ala Phe Pro Ile 305 310 315 320 Ser Gly Lys Leu Arg Gly His Phe Gln Leu Phe Asn Gly Tyr Gly Glu 325 330 335 Ser Leu Ile Asp Tyr Asn His Arg Ala Thr Tyr Ala Gly Leu Gly Val 340 345 350 Ser Leu Met Asn Trp Tyr 355 <210> SEQ ID NO 83 <211> LENGTH: 108 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 83 Met Glu Gly Leu Ser Val Thr Tyr Asn Gly Ser Thr Asp Thr Ala Ile 1 5 10 15 Ile Lys Gly Gln Val Gln Ser Gln Ala Asp Lys Glu Lys Ile Ile Leu 20 25 30 Ile Val Gly Asn Val Asp His Val Ala Gln Val Asp Asp Gln Met Thr 35 40 45 Val Ala Thr Pro Glu Pro Glu Ser Lys Phe Tyr Thr Val Lys Ser Gly 50 55 60 Asp Asn Leu Ser Lys Ile Ala Lys Glu Phe Tyr Gly Asp Ala Asn Gln 65 70 75 80 Tyr Gln Lys Ile Phe Glu Ala Asn Lys Pro Met Leu Lys Asp Pro Asp 85 90 95 Glu Ile Phe Pro Gly Gln Val Leu Arg Ile Pro Gln 100 105 <210> SEQ ID NO 84 <211> LENGTH: 291 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 84 Met Thr Ala Ile Thr Ala Ser Met Val Lys Glu Leu Arg Asp Arg Thr 1 5 10 15 Gly Leu Ala Met Met Glu Cys Lys Lys Ala Leu Thr Glu Ala Asn Gly 20 25 30 Asp Ile Glu Leu Ala Ile Asp Asn Leu Arg Lys Ser Gly Gln Ala Lys 35 40 45 Ala Ala Lys Lys Ala Gly Asn Ile Ala Ala Asp Gly Ala Ile Thr Ile 50 55 60 Val Gln Asp Gly Asn Lys Ala Ile Leu Val Glu Val Asn Cys Gln Thr 65 70 75 80 Asp Phe Val Ala Lys Asp Glu Asn Phe Ser Asn Phe Ala His Thr Val 85 90 95 Ala Ala Ala Ala Leu Ala Ala Gly Glu Thr Asp Ala Ala Lys Ile Ala 100 105 110 Glu Leu Lys Leu Ala Asp Gly Gln Ser Val Glu Glu Ala Arg Ile Ala 115 120 125 Leu Val Gln Lys Ile Gly Glu Asn Ile Gln Val Arg Arg Ala Lys Ile 130 135 140 Val Glu Gly Glu Gln Leu Ala Ile Tyr Lys His Gly Leu Lys Ile Gly 145 150 155 160 Val Val Val Ser Tyr Thr Gly Asp Ala Asp Thr Gly Lys Gly Ile Ala 165 170 175 Met His Val Ala Ala Phe Asn Pro Val Ala Val Asn Ala Glu Ala Val 180 185 190 Pro Ala Asp Leu Ile Ala Lys Glu Lys Glu Ile Ala Glu Ala Lys Ala 195 200 205 Leu Glu Ser Gly Lys Pro Ala Asn Ile Val Glu Lys Met Val Thr Gly 210 215 220 Ser Val Glu Lys Tyr Leu Asn Glu Val Ala Leu Asp Arg Gln Met Tyr 225 230 235 240 Val Ile Asp Asn Glu Lys Lys Val Ala Asp Val Leu Lys Ala Thr Gly 245 250 255 Thr Asn Val Ala Asn Phe Val Arg Phe Glu Val Gly Glu Gly Ile Glu 260 265 270 Lys Lys Ala Glu Leu Ser Phe Ala Glu Glu Val Ala Ala Ala Gln Ala 275 280 285 Ala Ala Lys 290 <210> SEQ ID NO 85 <211> LENGTH: 170 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 85 Met Thr Gly Cys Ala Ser Arg Lys Pro Ala Thr Thr Ala Thr Thr Gly 1 5 10 15 Thr Thr Asn Pro Ser Thr Val Asn Thr Thr Gly Leu Ser Glu Asp Ala 20 25 30 Ala Leu Asn Ala Gln Asn Leu Ala Gly Ala Ser Ser Lys Gly Val Thr 35 40 45 Glu Ala Asn Lys Ala Ala Leu Ala Lys Arg Val Val His Phe Asp Tyr 50 55 60 Asp Ser Ser Asp Leu Ser Thr Glu Asp Tyr Gln Thr Leu Gln Ala His 65 70 75 80 Ala Gln Phe Leu Met Ala Asn Ala Asn Ser Lys Val Ala Leu Thr Gly 85 90 95 His Thr Asp Glu Arg Gly Thr Arg Glu Tyr Asn Met Ala Leu Gly Glu 100 105 110 Arg Arg Ala Lys Ala Val Gln Asn Tyr Leu Ile Thr Ser Gly Val Asn 115 120 125 Pro Gln Gln Leu Glu Ala Val Ser Tyr Gly Lys Glu Ala Pro Val Asn 130 135 140 Pro Gly His Asp Glu Ser Ala Trp Lys Glu Asn Arg Arg Val Glu Ile 145 150 155 160 Asn Tyr Glu Ala Val Pro Pro Leu Leu Lys 165 170 <210> SEQ ID NO 86 <211> LENGTH: 144 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 86 Met Lys Lys Ile Ile Phe Leu Gly Leu Ala Leu Val Ser Leu Thr Ala 1 5 10 15 Cys Ser Ser Val Gln His Lys Asp Ser Thr Pro Pro Lys Ile Gly Ser 20 25 30 Pro Asn Pro Ala Ser Gln Tyr Cys Val Glu Gln Gly Gly Lys Leu Glu 35 40 45 Ile Arg Asn Glu Ala Asn Gly Gln Val Gly Tyr Cys His Leu Pro Asn 50 55 60 Gly Gln Val Val Glu Glu Trp Lys Leu Phe Arg Asp Asn Gln Ala Asn 65 70 75 80 Cys Val Ser Glu Glu Ala Gln Lys Leu Val Gly Leu Ser Gly Leu Thr 85 90 95

Asp Asp Gln Ile Lys Gln Lys Thr Lys Ser Glu Ile Val Arg Lys Val 100 105 110 Ala Pro Gly Gln Pro Met Thr Met Asp Tyr Arg Ser Asn Arg Val Thr 115 120 125 Val Thr Ile Asp Pro Thr Ser Lys Lys Ile Thr Gln Ala Thr Cys Gly 130 135 140 <210> SEQ ID NO 87 <211> LENGTH: 249 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 87 Met Lys Val Leu Arg Val Leu Val Thr Thr Thr Ala Leu Leu Ala Ala 1 5 10 15 Gly Ala Ala Met Ala Asp Glu Ala Val Val His Asp Ser Tyr Ala Phe 20 25 30 Asp Lys Asn Gln Leu Ile Pro Val Gly Ala Arg Ala Glu Val Gly Thr 35 40 45 Thr Gly Tyr Gly Gly Ala Leu Leu Trp Gln Ala Asn Pro Tyr Val Gly 50 55 60 Leu Ala Leu Gly Tyr Asn Gly Gly Asp Ile Ser Trp Thr Asp Asp Val 65 70 75 80 Ser Val Asn Gly Thr Lys Tyr Asp Leu Asp Met Asp Asn Asn Asn Val 85 90 95 Tyr Leu Asn Ala Glu Ile Arg Pro Trp Gly Ala Ser Thr Asn Pro Trp 100 105 110 Ala Gln Gly Leu Tyr Ile Ala Ala Gly Ala Ala Tyr Leu Asp Asn Asp 115 120 125 Tyr Asp Leu Ala Lys Arg Ile Gly Asn Gly Asp Thr Leu Ser Ile Asp 130 135 140 Gly Lys Asn Tyr Gln Gln Ala Val Pro Gly Gln Glu Gly Gly Val Arg 145 150 155 160 Gly Lys Met Ser Tyr Lys Asn Asp Ile Ala Pro Tyr Leu Gly Phe Gly 165 170 175 Phe Ala Pro Lys Ile Ser Lys Asn Trp Gly Val Phe Gly Glu Val Gly 180 185 190 Ala Tyr Tyr Thr Gly Asn Pro Lys Val Glu Leu Thr Gln Tyr Asn Leu 195 200 205 Ala Pro Val Thr Gly Asn Pro Thr Ser Ala Gln Asp Ala Val Asp Lys 210 215 220 Glu Ala Asn Glu Ile Arg Asn Asp Asn Lys Tyr Glu Trp Met Pro Val 225 230 235 240 Gly Lys Val Gly Val Asn Phe Tyr Trp 245 <210> SEQ ID NO 88 <211> LENGTH: 999 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 88 Met Arg Ala Val Glu Gly Asp Arg Leu Leu Ile Leu Lys His Gly Asp 1 5 10 15 Val Trp Lys Arg Met Ala Val Gly Phe Lys Met Asp Leu Asn His Trp 20 25 30 Asp Pro Arg Ile Glu Ala Gln Arg Ser Trp Phe Ile Ser Arg Gln Pro 35 40 45 Tyr Leu Asp Arg Leu Ser Ala Arg Ala Ser Arg Tyr Leu Tyr His Thr 50 55 60 Val Lys Glu Ala Glu Arg Arg Gly Leu Pro Thr Glu Leu Ala Leu Leu 65 70 75 80 Pro Val Ile Glu Ser Ser Tyr Asp Pro Ala Ala Thr Ser Ser Ala Ala 85 90 95 Ala Ala Gly Leu Trp Gln Phe Ile Pro Ser Thr Gly Arg Ile Tyr Gly 100 105 110 Leu Gln Gln Thr Gly Met Tyr Asp Gly Arg Arg Asp Val Val Glu Ser 115 120 125 Thr Arg Ala Ala Tyr Glu Phe Leu Gly Ser Leu Tyr Asn Gln Phe Gly 130 135 140 Ser Trp Glu Leu Ala Leu Ala Ala Tyr Asn Ala Gly Pro Gly Arg Ile 145 150 155 160 Gln Gln Ala Ile Asn Arg Asn Gln Ala Ala Gly Leu Pro Thr Asp Tyr 165 170 175 Trp Ser Leu Lys Leu Pro Gln Glu Thr Met Asn Tyr Val Pro Arg Phe 180 185 190 Leu Ala Val Ala Gln Ile Ile Lys Asn Pro Arg Ala Tyr Gly Val Ser 195 200 205 Leu Pro Pro Ile Ala Asn Arg Pro His Phe Arg Glu Val Thr Leu Ser 210 215 220 Ala Pro Leu Ser Leu Asn Glu Ile Ala Ser Val Thr Gly Leu Ser Arg 225 230 235 240 Ala Glu Leu Tyr Ala Leu Asn Pro Gly Tyr Arg Gly Glu Thr Val Asp 245 250 255 Pro Ala Ser Pro Met Arg Ile Leu Ile Pro Ala Asp Ile Ser Pro Ser 260 265 270 Val Asp Asn Lys Leu Lys Gly Met Lys Ala Gly Gly Ser Ser Gly Trp 275 280 285 Trp Ala Ser Val Thr Ser Pro Ser Lys Pro Thr Thr Thr Thr Ser Thr 290 295 300 Ser Val Thr Val Arg Thr Thr Pro Ser Thr Pro Ala Gln Pro Val Arg 305 310 315 320 Pro Ser Thr Pro Ala Lys Thr Ser Ser Ser Ser Val Thr Val Lys Thr 325 330 335 Ala Thr Pro Arg Gly Ser Asp Ala Leu Ala Ala Phe Ala Ala Ser Ala 340 345 350 Asp Val Pro Ser Ala Pro Arg Ile Pro Val Ala Val Thr Pro Ala Ala 355 360 365 Asn Ile Lys Pro Val Arg Thr Glu Pro Pro Ile Ser Ala Thr Glu Arg 370 375 380 Glu Lys Ile Leu Ala Ala Val Arg Ala Glu Gly Glu Lys Glu Thr Val 385 390 395 400 Asp Gln Ala Leu Glu Pro Gln Ala Thr Gln Ala Glu Lys Asp Gln Val 405 410 415 Val Ala Glu Leu Lys Ala Leu Ala Pro Gln Gly Thr Glu Ile Val Asp 420 425 430 Pro Tyr Asp Gly Lys Ile Lys Leu Thr Ala Ile Gln Thr Ser Gln Ser 435 440 445 Val Ala Glu Gln Gln Gly Lys Glu Val Ser Lys Gly Phe Ala Tyr Pro 450 455 460 Lys Thr Leu Ala Glu Asp Ala Thr Leu Ala Asn Ser Glu Asp Ala Gln 465 470 475 480 Arg Asn Lys Asp Lys Pro Tyr Ile Lys Thr Asp Thr Asp Val Val Val 485 490 495 Val Gln Pro Lys Gly Lys Arg Ser Thr Tyr Thr Val Gln Pro Gly Asp 500 505 510 Thr Leu Ala Val Ile Ala Met Lys Asn Gly Val Asn Trp Arg Asp Val 515 520 525 Ala Lys Trp Asn Gln Ile Asp Pro Glu Lys Thr Leu Phe Val Gly Thr 530 535 540 Ser Leu Tyr Leu Tyr Asp Ala Lys Pro Gln Glu Ala Glu Thr Thr Ala 545 550 555 560 Lys Ser Ala Ala Lys Pro Asp Val Tyr Val Val Gln Ala Asn Asp Ser 565 570 575 Leu Thr Gly Val Ala Asn Gln Phe Asn Leu Ser Val Lys Gln Leu Ala 580 585 590 Glu Tyr Asn Asp Leu Ser Val Thr Asp Gly Leu Phe Val Gly Gln Lys 595 600 605 Leu Gln Leu Lys Glu Pro Lys Gly Asn Arg Ala Ala Lys Val Glu Pro 610 615 620 Lys Ala Ile Gln Ala Ser Thr Arg Arg Ile Ala Thr Lys Ser Tyr Thr 625 630 635 640 Val Lys Arg Gly Glu Tyr Leu Lys Leu Ile Ala Asp Arg Tyr Ala Leu 645 650 655 Ser Asn Gln Glu Leu Ala Asp Leu Thr Pro Gly Leu Thr Ala Gly Ser 660 665 670 Asn Leu Ile Val Gly Gln Lys Ile Asn Val Pro Ala Lys Glu Ile Thr 675 680 685 Val Asp Glu Val Asp Asp Ser Lys Ala Ser Gly Lys Tyr Glu Lys Leu 690 695 700 Ala Ala Gly Pro Ser Tyr Lys Thr Glu Ser Tyr Lys Val Gln Arg Gly 705 710 715 720 Asp Thr Leu Ser Ser Ile Ala Thr Lys Ser Lys Ile Ser Leu Ala Glu 725 730 735 Leu Ala Glu Leu Asn Asn Leu Lys Ala Asn Ser His Val Gln Leu Gly 740 745 750 Gln Thr Leu Lys Val Pro Ala Gly Ala Ser Val Pro Asp Gln Tyr Val 755 760 765 Val Gln Ser Gly Asp Ser Leu Asn Ala Ile Ala Ala Lys Tyr Asn Leu 770 775 780 Gln Thr Ser Tyr Leu Ala Asp Leu Asn Gly Leu Ser Arg Thr Ala Gly 785 790 795 800 Leu Arg Ala Gly Gln Arg Leu Lys Leu Thr Gly Glu Val Glu Thr Thr 805 810 815 Ser Lys Val Ser Ala Lys Asn Thr Lys Glu Glu Thr Pro Glu Thr Tyr 820 825 830 Thr Val Lys Ser Gly Asp Ser Leu Gly Asn Ile Ala Asn Arg Tyr His 835 840 845 Leu Gln Leu Asp Tyr Leu Ala Ala Leu Asn Gly Leu Ser Arg Asn Ser 850 855 860 Asn Val Arg Val Gly Gln Arg Leu Lys Leu Thr Gly Asp Leu Pro Thr 865 870 875 880 Val Glu Thr Ala Lys Thr Asp Thr Ala Lys Ser Ser Pro Lys Ala Val 885 890 895 Val Ala Gly Lys Asn Thr Glu Lys Tyr Thr Val Lys Ala Gly Glu Ser 900 905 910 Leu Asn Ala Ile Ala Ser Arg Ala Gly Ile Ser Val Arg Glu Leu Ala 915 920 925 Glu Met Asn Ala Leu Lys Ala Asn Ala Asn Leu Gln Arg Gly Gln Asn 930 935 940 Ile Val Ile Pro Lys Thr Val Val Glu Tyr Lys Val Lys Arg Gly Asp

945 950 955 960 Thr Leu Ile Gly Leu Ala Ser Lys Tyr Gly Leu Glu Thr Thr Leu Leu 965 970 975 Ala Glu Leu Asn Asn Leu Thr Pro Ser Thr Gln Leu Arg Ile Gly Asp 980 985 990 Ile Ile Lys Val Pro Asn Leu 995 <210> SEQ ID NO 89 <211> LENGTH: 519 <212> TYPE: PRT <213> ORGANISM: Acinetobacter baumannii <400> SEQUENCE: 89 Met Arg Asn Ser Ala Met Gln Gln Leu Asn Pro Ser Glu Ile Ser Ala 1 5 10 15 Leu Ile Lys Gln Arg Ile Gly Asp Leu Asp Thr Ser Ala Thr Ala Lys 20 25 30 Asn Glu Gly Thr Ile Val Met Val Ser Asp Gly Ile Val Arg Ile His 35 40 45 Gly Leu Ala Asp Ala Met Tyr Gly Glu Met Ile Glu Phe Asp Gly Gly 50 55 60 Leu Phe Gly Met Ala Leu Asn Leu Glu Gln Asp Ser Val Gly Ala Val 65 70 75 80 Val Leu Gly Asn Tyr Leu Ser Leu Gln Glu Gly Gln Lys Ala Arg Cys 85 90 95 Thr Gly Arg Val Leu Glu Val Pro Val Gly Pro Glu Leu Leu Gly Arg 100 105 110 Val Val Asp Ala Leu Gly Asn Pro Ile Asp Gly Lys Gly Pro Ile Asp 115 120 125 Ala Lys Leu Thr Asp Ala Val Glu Lys Val Ala Pro Gly Val Ile Trp 130 135 140 Arg Gln Ser Val Asp Glu Pro Val Gln Thr Gly Tyr Lys Ser Val Asp 145 150 155 160 Thr Met Ile Pro Val Gly Arg Gly Gln Arg Glu Leu Ile Ile Gly Asp 165 170 175 Arg Gln Thr Gly Lys Thr Ala Met Ala Ile Asp Ala Ile Ile Ala Gln 180 185 190 Lys His Ser Gly Ile Lys Cys Val Tyr Val Ala Ile Gly Gln Lys Gln 195 200 205 Ser Thr Ile Ala Asn Val Val Arg Lys Leu Glu Glu Thr Gly Ala Met 210 215 220 Ala Tyr Thr Thr Val Val Ala Ala Ala Ala Ala Asp Pro Ala Ala Met 225 230 235 240 Gln Tyr Leu Ala Pro Tyr Ser Gly Cys Thr Met Gly Glu Tyr Phe Arg 245 250 255 Asp Arg Gly Glu Asp Ala Leu Ile Ile Tyr Asp Asp Leu Ser Lys Gln 260 265 270 Ala Val Ala Tyr Arg Gln Ile Ser Leu Leu Leu Arg Arg Pro Pro Gly 275 280 285 Arg Glu Ala Tyr Pro Gly Asp Val Phe Tyr Leu His Ser Arg Leu Leu 290 295 300 Glu Arg Ala Ser Arg Val Ser Ala Asp Tyr Val Glu Lys Phe Thr Asn 305 310 315 320 Gly Ala Val Thr Gly Gln Thr Gly Ser Leu Thr Ala Leu Pro Ile Ile 325 330 335 Glu Thr Gln Ala Gly Asp Val Ser Ala Phe Val Pro Thr Asn Val Ile 340 345 350 Ser Ile Thr Asp Gly Gln Ile Phe Leu Glu Thr Ser Leu Phe Asn Ala 355 360 365 Gly Ile Arg Pro Ala Val Asn Ala Gly Ile Ser Val Ser Arg Val Gly 370 375 380 Gly Ser Ala Gln Thr Lys Ile Ile Lys Lys Leu Ser Gly Gly Ile Arg 385 390 395 400 Thr Ala Leu Ala Gln Tyr Arg Glu Leu Ala Ala Phe Ala Gln Phe Ala 405 410 415 Ser Asp Leu Asp Glu Ala Thr Arg Lys Gln Leu Glu His Gly Gln Arg 420 425 430 Val Thr Glu Leu Met Lys Gln Lys Gln Tyr Ala Pro Tyr Ser Ile Ala 435 440 445 Asp Gln Ala Val Ser Val Tyr Ala Ser Asn Glu Gly Tyr Met Ala Asp 450 455 460 Val Glu Val Lys Lys Ile Val Asp Phe Asp Ala Ala Leu Ile Ser Tyr 465 470 475 480 Phe Arg Ser Glu Tyr Ala Pro Leu Met Lys Gln Ile Asp Glu Thr Gly 485 490 495 Asp Tyr Asn Lys Asp Ile Glu Ala Ala Ile Lys Ser Gly Ile Glu Ser 500 505 510 Phe Lys Ala Thr Gln Thr Tyr 515 <210> SEQ ID NO 90 <400> SEQUENCE: 90 000 <210> SEQ ID NO 91 <400> SEQUENCE: 91 000 <210> SEQ ID NO 92 <400> SEQUENCE: 92 000 <210> SEQ ID NO 93 <400> SEQUENCE: 93 000 <210> SEQ ID NO 94 <400> SEQUENCE: 94 000 <210> SEQ ID NO 95 <400> SEQUENCE: 95 000 <210> SEQ ID NO 96 <400> SEQUENCE: 96 000 <210> SEQ ID NO 97 <400> SEQUENCE: 97 000 <210> SEQ ID NO 98 <400> SEQUENCE: 98 000 <210> SEQ ID NO 99 <400> SEQUENCE: 99 000 <210> SEQ ID NO 100 <211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: primer forward <400> SEQUENCE: 100 gctaattggt gaaggtagtc 20 <210> SEQ ID NO 101 <211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: primer reverse <400> SEQUENCE: 101 gacgaatcgt ttgaatctgc 20

Claims

1. A vaccine composition suitable for the prophylactic treatment of an infection caused by an Acinetobacter baumannii strain in a mammal, which comprises: a. an Acinetobacter baumannii strain deficient in lipopolysaccharide (LPS) characterized by the partial or complete inactivation of one or various cellular nucleic acid molecules that encode endogenous LPS; and/or b. an outer membrane vesicle (OMV) derived from an Acinetobacter baumannii strain deficient in lipopolysaccharide (LPS) as defined in paragraph a) above.

2. The vaccine composition of claim 1, wherein the Acinetobacter baumannii strain deficient in lipopolysaccharide (LPS) is characterized by the partial or complete inactivation of one or more genes selected from the group consisting of IpxA, IpxB and IpxC.

3. The vaccine composition of claim 1, wherein said vaccine further comprises a recombinant polypeptide selected from the group consisting of: a. An amino acid sequence SEQ ID NO: 27 (putative ferric siderophore receptor (A. baumannii ATCC 17978; accession number YP_001084684)) or a fragment thereof, wherein the fragment is a biologically active fragment selected from the group consisting of SEQ ID NO: 1 to SEQ ID NO: 11 or any combination thereof, and an amino acid sequence having at least 85% identity with any of sequences SEQ ID NO: 1 to SEQ ID NO: 11; and b. An amino acid sequence SEQ ID NO: 28 (putative ferric hydroximate siderophore receptor (A. baumannii ATCC 17978; accession number YP_001084696)) or a fragment thereof, wherein the fragment is a biologically active fragment selected from the group consisting of SEQ ID NO: 12 to SEQ ID NO: 23 or any combination thereof, and sequences that have at least 85% identity with the amino acids SEQ ID NO: 12 to SEC ID NO: 23.

4. The vaccine composition of claim 1, that further comprises a purified outer membrane protein sequence of A. baumannii selected from the group consisting of: SEQ ID NO: 29, SEQ ID NO: 30, SEQ ID NO: 31, SEQ ID NO: 32, SEQ ID NO: 33, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 36, SEQ ID NO: 37, SEQ ID NO: 38, SEQ ID NO: 39, SEQ ID NO: 40, SEQ ID NO: 41, SEQ ID NO: 42, SEQ ID NO: 43, SEQ ID NO: 44, SEQ ID NO: 45, SEQ ID NO: 46; SEQ ID NO: 47; SEQ ID NO: 48; SEQ ID NO: 49; SEQ ID NO: 50; SEQ ID NO: 51; SEQ ID NO: 52; SEQ ID NO: 53; SEQ ID NO: 54; SEQ ID NO: 55; SEQ ID NO: 56; SEQ ID NO: 57; SEQ ID NO: 58; SEQ ID NO: 59; SEQ ID NO: 60; SEQ ID NO: 61; SEQ ID NO: 62; SEQ ID NO: 63; SEQ ID NO: 64; SEQ ID NO: 65; SEQ ID NO: 66; SEQ ID NO: 67; SEQ ID NO: 68; SEQ ID NO: 69; SEQ ID NO: 70; SEQ ID NO: 71; SEQ ID NO: 72; SEQ ID NO: 73; SEQ ID NO: 74; SEQ ID NO: 75; SEQ ID NO: 76, SEQ ID NO: 77, SEQ ID NO: 78, SEQ ID NO: 79, SEQ ID No: 80, SEQ ID NO: 81, SEQ ID NO: 82, SEQ ID NO: 83, SEQ ID NO: 84, SEQ ID NO: 85, SEQ ID NO: 86, SEQ ID NO: 87, SEQ ID NO: 88, SEQ ID NO: 89, and any combination thereof.

5. The vaccine composition of claim 1, wherein said vaccine further comprises the fusion recombinant polypeptide of SEQ ID NO: 24 or 25 or the fusion recombinant polypeptide coded by the nucleic acid molecule of SEQ ID NO: 26.

6. The vaccine composition of claim 3, wherein the Acinetobacter baumannii strain deficient in lipopolysaccharide (LPS) comprises or is transformed, transduced or transfected with a nucleotide sequence capable of coding for any of the amino acid sequences as defined in claim 3 so that such strain is capable of producing the exogenous expression any of said amino acid sequences.

7. The vaccine composition of claim 3, wherein said vaccine composition further comprises a vector, such as viral vector, a plasmid or an expression cassette comprising a nucleotide sequence capable of coding for any of the amino acid sequences as defined in claim 3 and expressing said amino acid sequences.

8. The vaccine composition of claim 1, wherein said Acinetobacter baumannii strain deficient in lipopolysaccharide (LPS) is inactivated.

9. The vaccine composition of claim 1, wherein the Acinetobacter baumannii strain deficient in lipopolysaccharide (LPS) is derived from ATCC strain 19606.

10. (canceled)

11. A vaccine composition comprising an antibody (monoclonal or polyclonal) or a fragment thereof selected from the group list consisting of Fab, Fab', Fab'-SH, Fv, scFv, F(ab').sub.2, Vhh, nanobody and diabody, capable of specifically binding the Acinetobacter baumannii strain deficient in lipopolysaccharide (LPS) and/or the outer membrane vesicle (OMV) derived therefrom as defined in claim 1.

12. A vaccine composition comprising an isolated antibody (monoclonal or polyclonal) or a fragment thereof selected from the group consisting of Fab, Fab', Fab'-SH, Fv, scFv, F(ab').sub.2, Vhh, nanobody and diabody, obtained or obtainable after immunizing a mammal with the vaccine composition as defined in claim 1.

13. (canceled)

14. An Acinetobacter baumannii strain deficient in lipopolysaccharide (LPS) characterized by the partial or complete inactivation of one or various cellular nucleic acid molecules that encode endogenous LPS, optionally by the partial or complete inactivation of one or more genes selected from the group consisting of IpxA, IpxB and IpxC, transformed, transduced or transfected with a nucleotide sequence capable of coding for any of the amino acid sequences as defined in claim 3 so that such strain is capable of producing the exogenous expression any of said amino acid sequences.

15. An Acinetobacter baumannii strain deficient in lipopolysaccharide (LPS) as defined in claim 1, for use as a medicament.

16. A method for the production of antibodies or fragments thereof, optionally selected from the group consisting of Fab, Fab', Fab'-SH, Fv, scFv, F(ab')2, Vhh, nanobody and diabody, which comprises: Selecting an antibody or a fragment thereof, optionally from an antibody library; Using an Acinetobacter baumannii strain deficient in lipopolysaccharide (LPS) and/or an outer membrane vesicle (OMV) derived therefrom, as an antigenic target; Selecting those antibodies or fragments thereof having affinity or binding affinity or capable of specifically binding such strain and/or OMV; and Producing those antibodies or fragments thereof identified in step c) above.

17. (canceled)

18. A method for prophylactic treatment of an infection caused by A. baumannii in a mammal, comprising administering the vaccine composition of claim 1 to the mammal having an infection caused by A. baumannii, optionally wherein the mammal is a human.

19. A method for therapeutic treatment (after infection) of an infection caused by A. baumannii in a mammal, comprising administering the vaccine composition of claim 11 to the mammal having an infection caused by A. baumannii, optionally wherein the mammal is a human.