GENETIC VARIANTS AS MARKERS FOR USE IN DIAGNOSIS, PROGNOSIS AND TREATMENT OF EOSINOPHILIA, ASTHMA AND MYOCARDIAL INFARCTION

Abstract

Polymorphic variants (e.g., certain alleles of polymorphic markers) that have been found to be associated with high blood eosinophil counts, conditions causative of eosinophilia (e.g., asthma, myocardial infarction), and/or hypertension are provided herein. Such polymorphic markers are useful for diagnostic purposes, such as in methods of determining a susceptility, and for prognostic purposes, including methods of predicting prognosis and methods of assessing an individual for probability of a response to a therapeutic agent, as further described herein. Further applications utilize the polymorphic markers of the invention include, screening methods and genotyping methods. The invention furthermore provides related kits, computer-readable medium, and apparatus.

Description

BACKGROUND OF THE INVENTION

[0001] Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of diverse inflammatory responses, as well as modulators of innate and adaptive immunity. They represent a small percentage of the total white blood cell population and are recruited from the bone marrow into the circulation to inflammatory foci and activated by various cytokines, chemokines and adhesion molecules (Hogan et al., Clin. Exp. Allergy 38: 709-750 (2008)). Activated eosinophils release toxic compounds from their granules and secrete inflammatory and regulatory cytokines, chemokines, and growth factors, including many potent inducers of immune responses in asthma, eczema, rhinitis, and other inflammatory diseases (Hogan et al., 2008, supra). Eosinophils are a major component of the inflammatory response observed in asthma and they are often the dominant inflammatory cell present in the bronchi of asthmatics (Lee et al., Science 305: 1773-1776 (2004)).

[0002] Eosinophilia, or abnormally high eosinophil counts in the blood or body tissue, can be caused by conditions or diseases including, eczema, leukemia, autoimmune diseases, asthma, allergic rhinitis (hay fever), and parasitic infection, as well as certain side effects of drugs. Without treatment, high numbers of eosinophils can accumulate in the heart and other organs, which can lead to nerve damage, heart failure, lung disease, and blood clots.

[0003] While methods of treating eosinophilia and conditions causative of eosinophilia are known in the art, there remains a need for methods of determining a susceptibility to such conditions.

SUMMARY OF THE INVENTION

[0004] The present application provides materials and methods for determining a susceptibility to eosinophilia and to conditions causative of, related to, or associated with eosinophilia. These and numerous other benefits will be apparent from the description that follows.

[0005] One aspect of the invention is a method of determining a susceptibility to eosinophilia in a human individual. In a specific embodiment, the method comprises obtaining sequence data about a human individual identifying at least one allele of at least one polymorphic marker associated with at least one gene selected from a group of genes specified herein, wherein different alleles of the at least one polymorphic marker are associated with different susceptibilities to eosinophilia in humans, and determining a susceptibility to eosinophilia from the sequence data.

[0006] In another specific embodiment, the method comprises obtaining sequence data about a human individual identifying at least one allele of at least one polymorphic marker selected from a group of polymorphic markers further described herein, and markers in linkage disequilibrium therewith, wherein different alleles of the at least one polymorphic marker are associated with different susceptibilities to eosinophilia in humans, and determining a susceptibility to eosinophilia from the sequence data.

[0007] Another aspect of the invention is a method of determining a susceptibility to asthma in a human individual. In a specific aspect, the method comprises obtaining sequence data about a human individual identifying at least one allele of at least one polymorphic marker associated with at least one of the IL1RL1 gene, the IL33 gene, and the WDR36 gene, wherein different alleles of the at least one polymorphic marker are associated with different susceptibilities to asthma in humans, and determining a susceptibility to asthma from the sequence data.

[0008] In another specific aspect, the method comprises obtaining sequence data about a human individual identifying at least one allele of at least one polymorphic marker selected from the group consisting of: rs1420101, rs3939286, rs2416257, and rs9494145, and markers in linkage disequilibrium therewith, wherein different alleles of the at least one polymorphic marker is associated with different susceptibilities to asthma in humans, and determining a susceptibility to asthma from the sequence data.

[0009] Yet another aspect of the invention is a method of determining a susceptibility to myocardial infarction in a human individual. In one specific embodiment, the method comprises obtaining sequence data about a human individual identifying at least one allele of at least one polymorphic marker associated with at least one of the SH2B3 gene, the ATXN2 gene, and the WDR36 gene, wherein different alleles of the at least one polymorphic marker are associated with different susceptibilities to myocardial infarction in humans, and determining a susceptibility to myocardial infarction from the sequence data.

[0010] In another specific embodiment, the method comprises obtaining sequence data about a human individual identifying at least one polymorphic marker selected from the group consisting of: rs3184504 and rs653178, and markers in linkage disquilibrium therewith, wherein different alleles of the at least one polymorphic marker are associated with different susceptibilities to myocardial infarction in humans, and determining a susceptibility to myocardial infarction from the sequence data.

[0011] One aspect of the invention is a method of determining a susceptibility to hypertension in a human individual. In one specific embodiment, the method comprises obtaining sequence data about a human individual identifying at least one allele of at least one polymorphic marker associated with at least one of the SH2B3 gene, wherein different alleles of the at least one polymorphic marker are associated with different susceptibilities to hypertension in humans, and determining a susceptibility to hypertension from the sequence data.

[0012] In another specific embodiment, the method comprises obtaining sequence data about a human individual identifying at least one polymorphic marker selected from the group consisting of: rs3184504 and markers in linkage disquilibrium therewith, wherein different alleles of the at least one polymorphic marker are associated with different susceptibilities to hypertension in humans, and determining a susceptibility to hypertension from the sequence data.

[0013] Related aspects of the invention include a screening method, genotyping methods, and prognostic methods. For example, the invention includes a method of screening a candidate marker for assessing susceptibility to a condition causative of or correlative with eosinophilia. The method comprises analyzing the frequency of at least one allele of a polymorphic marker of a group further described herein in a population of human individuals diagnosed with the condition, wherein a significant difference in frequency of the at least one allele in the population of human individuals diagnosed with the condition as compared to the frequency of the at least one allele in a control population of human individuals is indicative of the allele as a marker of the condition.

[0014] The invention also includes methods of genotyping a nucleic acid sample obtained from a human individual at risk for, or diagnosed with, eosinophilia, asthma, myocardial infarction, or hypertension comprising determining the identity of at least one allele of at least one polymorphic marker in the sample, wherein the marker is one which associates with eosinophilia, asthma, myocardial infarction, or hypertension as described herein, or is a marker in linkage disequilibrium therewith. With regard to the inventive genotyping methods presented herein, it should be appreciated that the methods do not provide the identification of a number of alleles such that the entire genome of the human individual is genotyped. Rather, the inventive methods provide the identification of a number, e.g., 100 or less, of alleles of the human individual.

[0015] Also included are methods of predicting prognosis of an individual experiencing symptoms associated with, or an individual diagnosed with, eosinophilia, asthma, myocardial infarction, or hypertension. Each of the methods comprises obtaining nucleic acid sequence data about a human individual identifying at least one allele of at least one polymorphic marker associated with eosinophilia, asthma, myocardial infarction, or hypertension, as further described herein, wherein different alleles of the at least one polymorphic marker are associated with different susceptibilities to eosinophilia, asthma, myocardial infarction or hypertension in humans, and predicting prognosis of the individual from the nucleic acid sequence data.

[0016] Further included are methods of assessing an individual for probability of a response to a therapeutic agent for preventing, treating, and/or ameliorating symptoms associated with eosinophilia, asthma, myocardial infarction, or hypertension. Each of the methods comprises determining the identity of at least one allele of at least one polymorphic marker in a nucleic acid sample obtained from the individual, wherein the at least one polymorphic marker is one which associates with eosinophilia, asthma, myocardial infarction, or hypertension, as further described herein, wherein the identity of the at least one allele of the at least one polymorphic marker is indicative of a probability of a positive response to the therapeutic agent.

[0017] Other related aspects of the invention include materials for assessing susceptibility to eosinophilia, asthma, or myocardial infarction of a human individual. For example, the invention includes kits for assessing susceptibility of a human individual to eosinophilia, asthma, myocardial infarction, or hypertension. Each of the kits comprises reagents for selectively detecting at least one allele of at least one polymorphic marker of a group as described herein in the genome of the individual, and a collection of data comprising correlation data between the polymorphic markers and susceptibility to eosinophilia, asthma, myocardial infarction, or hypertension.

[0018] The invention also includes computer-readable medium having computer executable instructions for determining susceptibility to eosinophilia, asthma, myocardial infarction, or hypertension. Each of the computer-readable medium comprises data indicative of at least one polymorphic marker; a routine stored on the computer readable medium and adapted to be executed by a processor to determine risk of developing eosinophilia, asthma, myocardial infarction, or hypertension for the at least one polymorphic marker, wherein the at least one polymorphic marker is associated with a gene which associates with eosinophilia, asthma, myocardial infarction, or hypertension as further described herein.

[0019] The invention further includes apparatus for determining a genetic indicator for eosinophilia, asthma, myocardial infarction, or hypertension in a human individual. Each of the apparatus of the invention comprises a processor, a computer readable memory having computer executable instructions adapted to be executed on the processor to analyze marker and/or haplotype information for at least one human individual with respect to at least one polymorphic marker associated with a gene which associates with eosinophilia, asthma, myocardial infarction, or hypertension, as further described herein, and generate an output based on the marker or haplotype information, wherein the output comprises a measure susceptibility of the at least one marker or haplotype as a genetic indicator of eosinophilia, asthma, myocardial infarction, or hypertension for the human individual.

[0020] Furthermore, the invention provides uses of an oligonucleotide probe which hybridizes to a segment of a nucleic acid comprising a polymorphic marker which is indicative of a susceptibility to eosinophilia, asthma, myocardial infarction, and/or hypertension in the manufacture of a diagnostic reagent for diagnosing and/or assessing susceptibility to eosinophilia, asthma, myocardial infarction, and/or hypertension. In a specific embodiment, the segment comprises a polymorpshism as described herein.

[0021] The invention moreover provides the use of an anti-eosinophilia agent, anti-asthma agent, anti-mycocardial infarction agent, or anti-hypertension in the preparation of a medicament for treating eosinophilia, asthma, or myocardial infarction in a human that has been tested for (a) the presence of at least one allele of at least one polymorphic marker which associates with eosinophilia, asthma, or myocardial infarction, as described herein; and/or (b) the presence of an amino acid substitution in an amino acid sequence encoded by the polymorphic marker. In some variations, the human tests positive for the presence of at least one allele which associates with the condition(s).

[0022] Further provided herein are improved methods of determining the safety and/or efficacy of a therapeutic agent used to treat eosinophila, asthma, myocardial infarction, or hypertension in a human individual. The method comprises obtaining sequence data about a human individual identifying at least one allele of at least one polymorphic marker selected from a group as described herein.

[0023] The invention moreover provides diagnostic methods of eosinophilia, asthma, or myocardial infarction. For example, the invention provides a method of diagnosing eosinophilia in a human individual comprising measuring the count of eosinophils in the blood of a human individual and obtaining sequence data identifying at least one allele of at least one polymorphic marker selected from a group of polymorphic markers described herein.

[0024] Also, for example, the invention provides a method of diagnosing asthma in a human individual, comprising (A) one or a combination of (i) considering symptoms experienced by the human individual and/or the family history of the human individual, (ii) physically examining the upper respiratory tract, chest, and skin of the human individual, and (iii) conducting a breathing test on the human individual, and (B) obtaining sequence data identifying at least one allele of at least one polymorphic marker selected from the group consisting of: rs1420101, rs3939286, rs2416257, and rs9494145, and markers in linkage disequilibrium therewith.

[0025] Further, the invention provides a method of diagnosing myocardial infarction in a human individual, comprising (A) one or a combination of (i) considering the history of an illness and the symptoms experienced by the human individual, (ii) physically examining the human individual, (iii) conducting one or a combination of an electrocardiogram, a coronary angiogram, chest radiograph, and echocardiogram on the human individual, (iv) testing blood of the human individual for cardiac markers, (v) detecting areas of reduced blood flow in conjunction with physiologic or pharmacologic stress, and (vi) determining the viability of tissue of the myocardium, and (B) obtaining sequence data identifying at least one allele of at least one polymorphic marker selected from the group consisting of: rs3184504 and rs653178, and markers in linkage disequilibrium therewith.

[0026] The original claims appended hereto are hereby incorporated by reference into the summary of the invention. Inventions described as uses should be considered to also constitute a description of methods or processes of using, and vice versa, in view of different jurisdictions' preferences for characterizing inventions differently.

[0027] The foregoing summary is not intended to define every aspect of the invention, and the heading "Summary of the Invention" is not intended to be limiting in any way; additional aspects of the invention and further details of the invention are described in other sections, such as the Drawing or Detailed Description. The entire document is intended to be related as a unified disclosure, and it should be understood that all combinations of features described herein are contemplated, even if the combination of features are not found together in the same sentence, or paragraph, or section of this document.

[0028] In addition to the foregoing, the invention includes, as an additional aspect, all embodiments of the invention narrower in scope in any way than the variations specifically mentioned above. Embodiments summarized in the Summary section are frequently further described, with preferred variations, in the Detailed Description, and these variations are part of the invention incorporated into the Summary by reference. With respect to aspects of the invention described as a genus (e.g., an anchor marker and markers in linkage disequilibrium with the anchor marker), all individual species (e.g., individual markers) are individually considered separate aspects of the invention. With respect to aspects of the invention that are described with reference to exemplary numerical values, it should be understood that such values are intended to describe ranges or sub-ranges that include the recited values. With respect to aspects described with numerical ranges, it should be understood that all subranges are contemplated.

[0029] Although the applicant(s) invented the full scope of the claims appended hereto, the claims appended hereto are not intended to encompass within their scope the prior art work of others. Therefore, in the event that statutory prior art within the scope of a claim is brought to the attention of the applicants by a Patent Office or other entity or individual, the applicant(s) reserve the right to exercise amendment rights under applicable patent laws to redefine the subject matter of such a claim to specifically exclude such statutory prior art or obvious variations of statutory prior art from the scope of such a claim. Variations of the invention defined by such amended claims also are intended as aspects of the invention. Additional features and variations of the invention will be apparent to those skilled in the art from the entirety of this application, and all such features are intended as aspects of the invention.

BRIEF DESCRIPTION OF THE DRAWINGS

[0030] FIG. 1 represents an overview of the study design, implementation, and results

[0031] FIG. 2 represents a quantile-quantile (QQ) plot of 312,719 SNPs in the genome-wide association scan for blood eosinophil counts. The horizontal line represents the threshold for genome-wide significance. The top diagonal line represents observations and the middle diagonal line represents the same data scaled down by an inflation factor of 1.11. The bottom diagonal line represents where the dots are expected to fall under the null hypothesis of no association.

[0032] FIG. 3 represents a distribution of mean standardized eosinophil counts in the Icelandic Discovery and Replication samples.

[0033] FIGS. 4A, 4E, 4I, 4M, 4Q, 4U, 4Y, 4AC, 4AG, and 4AK represent the pair-wise correlation structure in the indicated interval on the indicated chromosomal region. In each of FIGS. 4A, 4E, 4I, 4M, 4Q, 4U, 4Y, 4AC, 4AG, and 4AK, the upper plot shows pair-wise D' for n common SNPs (with MAF>5%) from the HapMap (v22) CEU dataset. The lower plot shows the corresponding r.sup.2 values. FIG. 4A--500 kb interval: 102.1-102.6 Mb, NCBI B36; ch. 2q12; n=868; FIG. 4E--500 kb interval: 213.3-213.8 Mb, NCBI B36; ch. 2q34; n=508; FIGS. 4I--500 kb interval: 129.5-130.0 Mb, NCBI B36; ch. 3q21; n=297; FIG. 4M--600 bp interval: 110.3-110.9 Mb, NCBI, B36; ch. 5q22; n=619; FIG. 4Q--500 kb interval: 131.65-132.15 Mb, NCBI B36; ch. 5q31; n=441; FIG. 4U--500 kb interval: 32-32.5 Mb, NCBI B36; ch. 6p21; n=813; FIG. 4Y--500 kb interval: 135.2-135.7 Mb, NCBI B36; ch. 6q23; n=464; FIG. 4AC--500 kb interval: 21.5-22.0 Mb, NCBI B36; ch. 8p21; n=407; FIG. 4AG--500 kb interval: 5.9-6.4 Mb; NCBI B36; ch. 9p24; n=495; FIG. 4AK--2 Mb interval: 110-112 Mb, NCBI B36; ch. 12q24; n=955.

[0034] FIGS. 4B, 4F, 4J, 4N, 4R, 4V, 4Z, 4AD, 4AH, and 4AL represent the estimated recombination rates (saRR) in cM/Mb from the HapMap Phase II data (Nature 449, 851-861 (18 Oct. 2007)) for the chromosomal region indicated in the corresponding A figure.

[0035] FIGS. 4C, 4G, 4K, 4O, 4S, 4W, 4AA, 4AE, 4AI, and 4AM represent the location of known genes in the region of indicated in the corresponding A figure.

[0036] FIGS. 4D, 4H, 4L, 4P, 4T, 4X, 4AB, 4AF, 4AJ, and 4AN represent a schematic view of the association with variation in eosinophil counts for all SNPs tested in the region indicated in the corresponding A figure in the genome-wide Icelandic data.

[0037] FIG. 5 represents the association of the SNPs, identified though the blood eosinophil count genome-wide scan, with differential white blood cell counts, platelet counts, and red blood. The SNPs are classified into having broad and narrow effects depending on the number of blood parameters with P<0.01. The middle tick shows the estimated effect and the end ticks mark its 95% confidence interval. The values behind this figure are given in Table 9. Association results with P<10.sup.-7, P<10.sup.-4, P<0.01, and P>0.01 are indicated by gradually thinning lines.

[0038] FIG. 6 shows an exemplary computer environment on which the methods and apparatus as described and claimed herein can be implemented.

[0039] FIG. 7 is a table denoting the SEQ ID NO: of the nucleotide sequence comprising the referenced SNP.

DETAILED DESCRIPTION OF THE INVENTION

Definitions

[0040] Unless otherwise indicated, nucleic acid sequences are written left to right in a 5' to 3' orientation. Numeric ranges recited within the specification are inclusive of the numbers defining the range and include each integer or any non-integer fraction within the defined range. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by the ordinary person skilled in the art to which the invention pertains.

[0041] The following terms shall, in the present context, have the meaning as indicated:

[0042] A "polymorphic marker," sometimes referred to as a "marker," as described herein, refers to a genomic polymorphic site. Each polymorphic marker has at least two sequence variations characteristic of particular alleles at the polymorphic site. Thus, genetic association to a polymorphic marker implies that there is association to at least one specific allele of that particular polymorphic marker. The marker can comprise any allele of any variant type found in the genome, including single nucleotide polymorphisms (SNPs), mini- or microsatellites, translocations and copy number variations (insertions, deletions, duplications). Polymorphic markers can be of any measurable frequency in the population. For mapping of disease genes, polymorphic markers with population frequency higher than 5-10% are in general most useful. However, polymorphic markers may also have lower population frequencies, such as 1-5% frequency, or even lower frequency, in particular copy number variations (CNVs). The term shall, in the present context, be taken to include polymorphic markers with any population frequency.

[0043] An "allele" refers to the nucleotide sequence of a given locus (position) on a chromosome. A polymorphic marker allele thus refers to the composition (i.e., sequence) of the marker on a chromosome. Genomic DNA from an individual contains two alleles for any given polymorphic marker, representative of each copy of the marker on each chromosome. Sequence codes for nucleotides used herein are: A=1, C=2, G=3, T=4. Sequence co-nucleotide ambiguity as described herein and in the accompanying sequence listing is as proposed by IUPAC-IUB (Table 1).

TABLE-US-00001 TABLE 1 IUB code Meaning A Adenosine (A) C Cytidine (C) G Guanine (G) T Thymidine (T) R G or A Y T or C K G or T M A or C S G or C W A or T B C, G or T D A, G or T H A, C or T V A, C or G N A, C, G or T (Any base)

[0044] For microsatellite alleles, the CEPH sample (Centre d'Etudes du Polymorphisme Humain, genomics repository, CEPH sample 1347-02) is used as a reference, the shorter allele of each microsatellite in this sample is set as 0 and all other alleles in other samples are numbered in relation to this reference. Thus, e.g., allele 1 is 1 bp longer than the shorter allele in the CEPH sample, allele 2 is 2 bp longer than the shorter allele in the CEPH sample, allele 3 is 3 bp longer than the lower allele in the CEPH sample, etc., and allele -1 is 1 bp shorter than the shorter allele in the CEPH sample, allele -2 is 2 bp shorter than the shorter allele in the CEPH sample, etc.

[0045] A nucleotide position at which more than one sequence is possible in a population (either a natural population or a synthetic population, e.g., a library of synthetic molecules) is referred to herein as a "polymorphic site".

[0046] A "Single Nucleotide Polymorphism" or "SNP" is a DNA sequence variation occurring when a single nucleotide at a specific location in the genome differs between members of a species or between paired chromosomes in an individual. Most SNP polymorphisms have two alleles. Each individual is in this instance either homozygous for one allele of the polymorphism (i.e., both chromosomal copies of the individual have the same nucleotide at the SNP location), or the individual is heterozygous (i.e., the two sister chromosomes of the individual contain different nucleotides). The SNP nomenclature as reported herein refers to the official Reference SNP (rs) ID identification tag as assigned to each unique SNP by the National Center for Biotechnological Information (NCBI).

[0047] A "variant", as described herein, refers to a segment of DNA that differs from the reference DNA. A "marker" or a "polymorphic marker", as defined herein, is a variant. Alleles that differ from the reference are referred to as "variant" alleles.

[0048] A "fragment" of a nucleotide or a protein, as described herein, comprises all or a part of the nucleotide or the protein.

[0049] An "animal", as described herein, refers to any domestic animal (e.g., cats, dogs, etc.), agricultural animal (e.g., cows, horses, sheep, chicken, etc.), or test species (e.g., rabbit, mouse, rat, etc.), and also includes humans.

[0050] A "microsatellite" is a polymorphic marker that has multiple small repeats of bases that are 2-8 nucleotides in length (such as CA repeats) at a particular site, in which the number of repeat lengths varies in the general population.

[0051] An "indel" is a common form of polymorphism comprising a small insertion or deletion that is typically only a few nucleotides long.

[0052] A "haplotype," as described herein, refers to a segment of genomic DNA within one strand of DNA that is characterized by a specific combination of alleles arranged along the segment. For diploid organisms such as humans, a haplotype comprises one member of the pair of alleles for each polymorphic marker or locus. In a certain embodiment, the haplotype can comprise two or more alleles, three or more alleles, four or more alleles, or five or more alleles. Haplotypes are described herein in the context of the marker name and the allele of the marker in that haplotype, e.g., "A rs1420101" refers to the A allele of marker rs1420101 being in the haplotype, and is equivalent to "rs1420101 allele A". Furthermore, allelic codes in haplotypes are as for individual markers, i.e. 1=A, 2=C, 3=G and 4=T.

[0053] The term "susceptibility", as described herein, encompasses both increased susceptibility and decreased susceptibility. Thus, particular polymorphic markers and/or haplotypes of the invention may be characteristic of increased susceptibility (i.e., increased risk) of eosinophilia, asthma, and/or myocardial infarction, as characterized by a relative risk (RR) of greater than one. Alternatively, the markers and/or haplotypes of the invention are characteristic of decreased susceptibility (i.e., decreased risk) of eosinophilia, asthma, and/or myocardial infarction, as characterized by a relative risk of less than one.

[0054] The term "and/or" shall in the present context be understood to indicate that either or both of the items connected by it are involved. In other words, the term herein shall be taken to mean "one or the other or both".

[0055] The term "look-up table", as described herein, is a table or data collection that correlates one form of data to another form, or one or more forms of data to a predicted outcome to which the data is relevant, such as phenotype or trait. For example, a look-up table can comprise a correlation between allelic data for at least one polymorphic marker and a particular trait or phenotype, such as a particular disease diagnosis, that an individual who comprises the particular allelic data is likely to display, or is more likely to display than individuals who do not comprise the particular allelic data. Look-up tables can be multidimensional, i.e., they can contain information about multiple alleles for single markers simultaneously, or the can contain information about multiple markers, and they may also comprise other factors, such as particulars about diseases diagnoses, racial information, biomarkers, biochemical measurements, therapeutic methods or drugs, etc.

[0056] A "computer-readable medium" is an information storage medium that can be accessed by a computer using a commercially available or custom-made interface. Exemplary compute-readable media include memory (e.g., RAM, ROM, flash memory, etc.), optical storage media (e.g., CD-ROM), magnetic storage media (e.g., computer hard drives, floppy disks, etc.), punch cards, or other commercially available media. Information may be transferred between a system of interest and a medium, between computers, or between computers and the computer-readable medium for storage or access of stored information. Such transmission can be electrical, or by other available methods, such as IR links, wireless connections, etc.

[0057] A "nucleic acid sample" is a sample obtained from an individual that contains nucleic acid (DNA or RNA). In certain embodiments, i.e. the detection of specific polymorphic markers and/or haplotypes, the nucleic acid sample comprises genomic DNA. Such a nucleic acid sample can be obtained from any source that contains genomic DNA, including as a blood sample, sample of amniotic fluid, sample of cerebrospinal fluid, or tissue sample from skin, muscle, buccal or conjunctival mucosa (buccal swab), placenta, gastrointestinal tract or other organs.

[0058] The term "polypeptide", as described herein, refers to a polymer of amino acids, and not to a specific length; thus, peptides, oligopeptides and proteins are included within the definition of a polypeptide.

[0059] The term "gene" as used herein refers to a locateable region of genomic sequence, corresponding to a unit of inheritance, which is associated with regulatory regions, transcribed regions, and/or other functional sequence regions.

[0060] The term "eosinophilia" as used herein refers to abnormally high eosinophil counts in the blood or body tissue. In most cases, the eosinophilia referenced herein means abnormally high eosinophil counts in the blood.

[0061] As used herein, the phrase "polymorphic marker associated with" used in reference to a gene, refers to a polymorphic marker which is found within or near the specified gene(s). The polymorphic marker associated with a gene can be found in an intron or exon of the gene. Alternatively, the polymorphic marker associated with a gene can be located in a transcriptional regulatory region of the gene, e.g., a promoter, enhancer, 3'UTR, 5' UTR of a gene, polyA tail, etc.

[0062] Through association analyses of populations of individuals found to have increased blood eosinophil counts, it is shown for the first time herein that certain variant alleles of certain polymorphic markers associate with high blood eosinophil counts. Because eosinophils play important roles in both asthma and myocardial infarction, subsequent studies described herein demonstrate that a subset of the variant alleles which associate with high blood eosinophil counts additionally associates with an increased risk of asthma or myocardial infarction. Without being bound to a particular theory, these variant alleles of the polymorphic markers described herein are contemplated as useful markers for determining susceptibility to eosinophilia and conditions causative of or correlated/associated with eosinophilia, such as asthma and myocardial infarction.

[0063] Methods of Determining Susceptibility to Eosinophilia

[0064] Accordingly, the invention provides methods of determining a susceptibility to eosinophilia in a human individual. In a specific embodiment, the method comprises obtaining sequence data about a human individual identifying at least one allele of at least one polymorphic marker selected from the group consisting of: rs1050152, rs11066320, rs11679137, rs11778166, rs11950562, rs12411706, rs9954643, rs12619285, rs1265566, rs12998521, rs1370631, rs1412426, rs1420101, rs1467412, rs1559930, rs1805419, rs184941, rs2079103, rs2164850, rs2165427, rs2188962, rs2244012, rs2269426, rs231228, rs2335050, rs233716, rs233722, rs2416257, rs2426358, rs2532072, rs2663041, rs272893, rs273148, rs2897443, rs3184504, rs3939286, rs4143832, rs4629469, rs4773225, rs4851400, rs4851411, rs4857855, rs6439132, rs6503609, rs653178, rs6730424, rs6871536, rs7150454, rs7223150, rs7315519, rs748065, rs7635061, rs927220, rs9494145, and rs992969, and markers in linkage disequilibrium therewith, which are the polymorphic markers listed in Table 3, and markers in linkage disequilibrium therewith, and haplotypes which comprise such markers, wherein different alleles of the at least one polymorphic marker (or different haplotypes) are associated with different susceptibilities to eosinophilia in humans, and determining a susceptibility to eosinophilia from the sequence data.

[0065] In a specific aspect of the invention, the at least one polymorphic marker is selected from the group consisting of: rs9954643, rs273148, rs3939286, rs1420101, rs11066320, rs4857855, rs9494145, rs2416257, rs2079103, rs2165427, rs3184504, rs2663041, rs1412426, rs11778166, rs4143832, rs653178, rs6730424, rs4629469, rs748065, rs11679137, rs2164850, rs12619285, rs2269426, rs7635061, rs184941, rs2532072, rs6503609, rs4773225, rs2426358, rs231228, rs7223150, and rs7150454, and markers in linkage disequilibrium therewith, which are the polymorphic markers listed in Table 4.

[0066] In yet another specific aspect of the invention, the at least one polymorphic marker is selected from the group consisting of: rs12619285, rs1412426, rs1420101, rs184941, rs2079103, rs2269426, rs2416257, rs3184504, rs3939286, rs4143832, rs4857855, rs653178, rs748065, rs7635061, and rs9494145, and markers in linkage disequilibrium therewith, which are the polymorphic markers shown in Tables 6 and 7. Alternatively, the at least one polymorphic marker is selected from the group consisting of: rs12619285, rs1420101, rs2269426, rs2416257, rs3184504, rs3939286, rs4143832, rs4857855, rs748065, and rs9494145, and markers in linkage disequilibrium therewith, which are the polymorphic markers listed in Table 6.

[0067] In a more specific aspect of the invention, the at least one polymorphic marker is selected from the group consisting of: rs12619285, rs1420101, rs3184504, rs4143832, rs4857855, and rs9494145, and markers in linkage disequilibrium therewith, which are the polymorphic markers that satisfy the criteria for genome wide significance as shown in Table 6.

[0068] In one aspect of the invention, the at least one allele can be one of: the C allele of rs1050152, the A allele of rs11066320, the G allele of rs11679137, the C allele of rs11778166, the A allele of rs11950562, the G allele of rs12411706, the G allele of rs9954643, the A allele of rs12619285, the T allele of rs1265566, the T allele of rs12998521, the A allele of rs1370631, the T allele of rs1412426, the A allele of rs1420101, the A allele of rs1467412, the A allele of rs1559930, the G allele of rs1805419, the G allele of rs184941, the T allele of rs2079103, the C allele of rs2164850, the A allele of rs2165427, the C allele of rs2188962, the C allele of rs2244012, the T allele of rs2269426, the C allele of rs231228, the C allele of rs2335050, the G allele of rs233716, the C allele of rs233722, the G allele of rs2416257, the C allele of rs2426358, the C allele of rs2532072, the T allele of rs2663041, the A allele of rs272893, the G allele of rs273148, the A allele of rs2897443, the T allele of rs3184504, the A allele of rs3939286, the A allele of rs4143832, the G allele of rs4629469, the G allele of rs4773225, the A allele of rs4851400, the T allele of rs4851411, the C allele of rs4857855, the T allele of rs6439132, the A allele of rs6503609, the G allele of rs653178, the T allele of rs6730424, the C allele of rs6871536, the G allele of rs7150454, the G allele of rs7223150, the A allele of rs7315519, the A allele of rs748065, the A allele of rs7635061, the C allele of rs927220, the T allele of rs9494145, and the A allele of rs992969, which are listed in Table 3.

[0069] Alternatively, the allele can be the allele of the complementary strand of DNA, such that the nucleic acid data includes the identification of at least one allele which is complementary to any of the alleles of the polymorphic markers referenced above.

[0070] Because some of the above referenced polymorphic markers are associated with and/or physically located within or near a particular gene (as shown in Table 3), it is believed that a susceptibility to eosinophilia can be determined based on nucleic acid or amino acid data of at least one of these genes. Accordingly, the invention provides a method of determining a susceptibility to eosinophilia in a human individual, the method comprises obtaining sequence data about a human individual identifying at least one allele of at least one polymorphic marker of at least one gene selected from the group consisting of: ATP9A, ATXN2, BAX, CUX2, IL1RL1, IL33, LBH, LOC441108, PTPN11, RAD50, RAD51L1, SH2B3, SLC22A4, SNX6, TBC1D8, TNKS2, TNXB, BRAP, ACAD10, ALDH2, MAPKAPK5, and ERP29, wherein different alleles of the at least one polymorphic marker of the at least one gene are associated with different susceptibilities to eosinophilia in humans, and determining a susceptibility to eosinophilia from the sequence data.

[0071] In a specific aspect of the invention, the method comprises obtaining sequence data about a human individual identifying at least one allele of at least one polymorphic marker of at least one gene selected from a sub-group of the above group of genes consisting of: LBH, TBC1D8, IL1RL1, WDR36, RAD50, TNXB, IL33, WDFY4, SH2B3, ATXN2, PTPN11, RAD51L1, SNX26, and ATP9A. In another specific aspect, the gene is selected from a group consisting of: IL1RL1, WDR36, TNXB, IL33, SH2B3, and ATXN2. In yet another specific aspect of the invention, the gene is selected from the group consisting of: IL1RL1, WDR36, TNXB, IL33, and SH2B3. The gene is IL1RL1 and/or SH2B3 in another aspect of the invention.

[0072] In one embodiment of the invention, the polymorphic marker of the at least one gene is one of rs11679137, rs4851400, rs2165427, rs1420101, rs2416257, rs11950562, rs272893, rs1050152, rs2188962, rs2244012, rs2897443, rs6871536, rs2269426, rs3939286, rs2663041, rs12411706, rs1265566, rs3184504, rs653178, rs11066320, rs7150454, rs927220, rs231228, rs1805419, rs1467412, and rs2426358, all of which are associated with and/or are physically located within one of the aforementioned genes.

[0073] Conditions Causative of, or Associated with or Correlative with Eosinophilia

[0074] In one aspect of the methods of determining a susceptibility to eosinophilia, the at least one allele further associates with a susceptibility to a condition which causes, correlates with, or associates with eosinophilia. In a specific embodiment of the invention, the at least one allele further associates with an increased susceptibility to a condition which causes, or is partially caused by, eosinophilia. The condition can be any condition, syndrome, or disease of which eosinophilia is a symptom. The condition can be, for example, eczema, leukemia, an autoimmune disease, an inflammatory disease, asthma, allergic rhinitis (hay fever), allergic rhinoconjuctivitis, atopic dermatitis, eosinophil esophagitis, eosinophilic fasciitis, a lung disease, vasculitis (e.g., Churg-Strauss syndrome), a tumor (e.g., a lymphoma), liver cirrhosis, an antibody deficiency, a myocardial infarction, rare skin diseases (e.g., dermatitis herptiformis, bullous pemphigoid), a parasitic infection (e.g., caused by helminths, e.g., nematodes, schistosomes and plasmodium species), or fungal infection such as Pneumocystis carinii pneumonia (Pcp). The condition can be a side effect of certain drugs. The side effect can be a side effect of an amphetamine, tranquilizer, bulk-type laxative containing psyllium, or an antibiotic. The drug can be an immunosuppressive drug, e.g., tacrolimus.

[0075] The autoimmune disease can be any disease in which the body produces an immune (i.e., immune system) response to some constituent of its own tissue. In other words the immune system loses its ability to recognize some tissue or system within the body as "self and targets and attacks it as if it were foreign, or loss of regulatory function of the immune system leads to its attack of the body's own constituents. Autoimmune diseases can be classified into those in which predominantly one organ is affected (e.g., hemolytic anemia and anti-immune thyroiditis), and those in which the autoimmune disease process is diffused through many tissues (e.g., systemic lupus erythematosus). For example, multiple sclerosis is thought to be caused by T cells attacking the sheaths that surround the nerve fibers of the brain and spinal cord. This results in loss of coordination, weakness, and blurred vision. Autoimmune diseases are known in the art and include, for instance, Hashimoto's thyroiditis, Grave's disease, lupus, multiple sclerosis, rheumatic arthritis, hemolytic anemia, anti-immune thyroiditis, systemic lupus erythematosus, celiac disease, Crohn's disease, colitis, diabetes, scleroderma, psoriasis, and the like.

[0076] The tumor can be a benign tumor, including, but not limited to any of a neoplasm, a hmartoma, a lipoma, a chondroma, a polyp, a cyst, fibroid, teratoma, or an adenoma. The tumor alternatively can be a malignant tumor, such as a malignant tumor of a cancer selected from: acute lymphocytic cancer, acute myeloid leukemia, alveolar rhabdomyosarcoma, bone cancer, brain cancer, breast cancer, cancer of the anus, anal canal, or anorectum, cancer of the eye, cancer of the intrahepatic bile duct, cancer of the joints, cancer of the neck, gallbladder, or pleura, cancer of the nose, nasal cavity, or middle ear, cancer of the oral cavity, cancer of the vulva, chronic lymphocytic leukemia, chronic myeloid cancer, colon cancer, esophageal cancer, cervical cancer, gastrointestinal carcinoid tumor, Hodgkin lymphoma, hypopharynx cancer, kidney cancer, larynx cancer, liver cancer, lung cancer, malignant mesothelioma, melanoma, multiple myeloma, nasopharynx cancer, non-Hodgkin lymphoma, ovarian cancer, pancreatic cancer, peritoneum, omentum, and mesentery cancer, pharynx cancer, prostate cancer, rectal cancer, renal cancer (e.g., renal cell carcinoma (RCC)), small intestine cancer, soft tissue cancer, stomach cancer, testicular cancer, thyroid cancer, ureter cancer, and urinary bladder cancer.

[0077] An inflammatory disease can be any disease in which inflammation contributes to the pathogenesis, progress or symptoms of the disease. Inflammatory diseases include e.g. allergic diseases, asthma, arthritic diseases (e.g. rheumatoid arthritis, shoulder tendinitis or bursitis, Gouty arthritis, polymyalgia rheumatica and osteoarthritis), atherosclerosis, chronic obstructive lung disease, chronic inflammation, chronic prostatitis, fibromyalgia, glomerulonephritis, hypersensitivities, inflammatory bowel diseases, inflammatory myopahthies, myocardial infarction, obstructive sleep apnea, pelvic inflammatory disease, transplant rejection, vasculitis, and many of the autoimmune diseases.

[0078] In a specific aspect of the invention, wherein the allele further associates with an increased susceptibility to a condition which causes eosinophilia, the condition is asthma. In a more specific aspect, the condition is atopic asthma and the at least one allele is the A allele of rs1420101, the A allele of rs3939286, the G allele of rs2416257, and/or the T allele of rs9494145. In an alternative aspect, the condition is non-atopic asthma and the at least one allele is the A allele of rs1420101.

[0079] In a specific aspect of the invention, wherein the allele further associates with an increased susceptibility to a condition which causes eosinophilia, the condition is myocardial infarction. In an aspect of this embodiment, the at least one allele is the T allele of rs3184504 and/or the G allele of rs653178.

[0080] Methods of Determining a Susceptibility to Asthma

[0081] In view of the foregoing, the invention provides a method of determining a susceptibilitly to asthma in a human individual. The method comprises obtaining data about a human individual identifying at least one allele of at least one polymorphic marker of at least one gene selected from the group consisting of: IL1RL1, IL33, and WDR36, or identifying at least one allele of at least one polymorphic marker selected from the group consisting of: rs1420101, rs3939286, rs2416257, and rs9494145, and markers in linkage disquilibrium therewith, wherein different alleles of the at least one polymorphic marker are associated with different susceptibilities to asthma in humans, and determining a susceptibility to asthma from the sequence data.

[0082] In a specific aspect of the invention, the asthma is atopic asthma and the polymorphic marker is one of rs1420101, rs3939286, rs2416257, and rs9494145, and markers in linkage disquilibrium therewith. In a more specific aspect, the allele of the polymorphic marker is one of the A allele of rs1420101, the A allele of rs3939286, the G allele of rs2416257, and the T allele of rs9494145.

[0083] In another specific aspect of the invention, the asthma is non-atopic asthma and the polymorphic marker is rs1420101, and markers in linkage disquilibrium therewith. In a more specific aspect of the invention, the allele of the polymorphic marker is the A allele of rs1420101.

[0084] Methods of Determining a Susceptibility to Myocardial Infarction

[0085] The invention furthermore provides a method of determining a susceptibility to myocardial infarction in a human individual. The method comprises obtaining sequence data about a human individual identifying at least one allele of at least one polymorphic marker of at least one gene selected from the group consisting of: SH2B3 and ATXN2, or identifying at least one allele of at least one polymorphic marker selected from the group consisting of: rs3184504 and rs653178, and markers in linkage disquilibrium therewith, wherein different alleles of the at least one polymorphic marker is associated with different susceptibilities to myocardial infarction in humans, and determining a susceptibility to myocardial infarction from the sequence data. In a specific embodiment, markers in linkage disequilibrium are selected from the group consisting of rs2106409, rs4766521, rs3919447, rs4766522, rs2106407, rs2106406, rs12425190, rs2339706, rs4509829, rs11838131, rs12818548, rs4766523, rs4766524, rs7961663, rs7961935, rs7978821, rs4766526, rs4766442, rs4766443, rs12815195, rs4766527, rs12814105, rs991817, rs11065784, rs7968960, rs4378452, rs10774613, rs1265566, rs7970490, rs3847953, rs6490055, rs11065884, rs10849944, rs7302763, rs10849946, rs4766573, rs10774623, rs12580300, rs11065898, rs10849947, rs2283358, rs7296313, rs2239195, rs2238154, rs3184504, rs739496, rs10849949, rs2073950, rs2301622, rs2301621, rs4766578, rs10774625, rs2339816, rs1029388, rs6490162, rs628825, rs630512, rs688812, rs657197, rs607316, rs616668, rs648997, rs625093, rs638791, rs593226, rs616559, rs616513, rs653178, rs12369009, rs695871, rs11065987, rs601663, rs2238151, rs10744777.

[0086] In a specific aspect of the invention, when the polymorphic marker is rs3184504 or rs653178, the allele of the polymorphic marker is one of the T allele of rs3184504 and the G allele of rs653178.

[0087] Methods of Determining a Susceptibility to Hypertension

[0088] The invention moreover provides a method of determining a susceptibility to hypertension in a human individual. The method comprises obtaining sequence data about a human individual identifying at least one allele of at least one polymorphic marker of at least one gene selected from the group consisting of: SH2B3, or identifying at least one allele of at least one polymorphic marker selected from the group consisting of: rs3184504, and markers in linkage disquilibrium therewith, wherein different alleles of the at least one polymorphic marker are associated with different susceptibilities to hypertension in humans, and determining a susceptibility to hypertension from the sequence data.

[0089] In a specific aspect of the invention, when the polymorphic marker is rs3184504, the allele of the polymorphic marker is the T allele of rs3184504.

[0090] Number of Polymorphic Markers/Genes Analyzed

[0091] With regard to the methods of determining a susceptibility described herein, the methods can comprise obtaining sequence data about any number of polymorphic markers and/or about any number of genes. For example, the method can comprise obtaining sequence data for about at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 30, 40, 50, 100, 500, 1000, 10,000 or more polymorphic markers or genes. The markers can be independent and/or some of the markers can be part of a haplotype. The polymorphic markers or genes can be the ones of the group specified herein or can be a different polymorphic marker or gene that is not listed in the group, including, for example, a different polymorphic marker or gene that has been previously identified as associating with eosinophilia, asthma, myocardial infarction, and/or hypertension. In a specific embodiment, the method comprises obtaining sequence data about at least two polymorphic markers from at least two different genes. For example, in some instances, if the method comprises obtaining nucleic acid data about a human individual identifying at least one allele of the polymorphic marker rs1420101, then the method comprises identifying at least one allele of at least one other polymorphic marker, e.g., a polymorphic marker which is not related to rs1420101 (e.g., a marker which is not in linkage disequilibrium with rs1420101). Also, for example, the method can comprise obtaining sequence data about a human individual identifying alleles of multiple, independent haplotypes, which are not in linkage disequilibrium. In another specific embodiment of the invention, the method comprises obtaining nucleic acid sequence data about at least one polymorphic marker from each gene or polymorphic marker of the specified group.

[0092] Obtaining Nucleic Acid Sequence Data

[0093] With regard to the methods of determining a susceptibility to eosinophilia, asthma, myocardial infarction, or hypertension, the sequence data can be nucleic acid sequence data, which may be obtained by means known in the art. For example, the nucleic acid sequence data may be obtained through direct analysis of the sequence of the allele of the polymorphic marker. Suitable methods, some of which are described herein, include, for instance, whole genome analysis using a whole genome SNP chip (e.g., Infinium HD BeadChip), cloning for polymorphisms, non-radioactive PCR-single strand conformation polymorphism analysis, denaturing high pressure liquid chromatography (DHPLC), DNA hybridization, computational analysis, single-stranded conformational polymorphism (SSCP), restriction fragment length polymorphism (RFLP), automated fluorescent sequencing; clamped denaturing gel electrophoresis (CDGE); denaturing gradient gel electrophoresis (DGGE), mobility shift analysis, restriction enzyme analysis; heteroduplex analysis, chemical mismatch cleavage (CMC), RNase protection assays, use of polypeptides that recognize nucleotide mismatches, such as E. coli mutS protein, allele-specific PCR, and direct manual sequencing. These and other methods are desribed in the art (see, for instance, Li et al., Nucleic Acids Research, 28(2): e1 (i-v) (2000); Liu et al., Biochem Cell Bio 80:17-22 (2000); and Burczak et al., Polymorphism Detection and Analysis, Eaton Publishing, 2000; Sheffield et al., Proc. Natl. Acad. Sci. USA, 86:232-236 (1989); Orita et al., Proc. Natl. Acad. Sci. USA, 86:2766-2770 (1989); Flavell et al., Cell, 15:25-41 (1978); Geever et al., Proc. Natl. Acad. Sci. USA, 78:5081-5085 (1981); Cotton et al., Proc. Natl. Acad. Sci. USA, 85:4397-4401 (1985); Myers et al., Science 230:1242-1246 (1985); Church and Gilbert, Proc. Natl. Acad. Sci. USA, 81:1991-1995 (1988); Sanger et al., Proc. Natl. Acad. Sci. USA, 74:5463-5467 (1977); and Beavis et al., U.S. Pat. No. 5,288,644).

[0094] In one embodiment, diagnosis of a susceptibility to eosinophilia, asthma, myocardial infarction, and/or hypertension can be accomplished using a hybridization method (see Current Protocols in Molecular Biology, Ausubel et al., eds., John Wiley & Sons, including all supplements). A biological sample of genomic DNA, RNA, or cDNA (a "test sample") is obtained from a test subject or individual suspected of having, being susceptible to, experiencing symptoms associated with, or predisposed for eosinophilia, asthma, and/or myocardial infarction (the "test subject"). The subject can be an adult, child, or fetus. A test sample of DNA from fetal cells or tissue can be obtained by appropriate methods, such as by amniocentesis or chorionic villus sampling. The DNA, RNA, or cDNA sample is then examined. The presence of a specific marker allele can be indicated by sequence-specific hybridization of a nucleic acid probe specific for the particular allele. The presence of more than one specific marker allele or a specific haplotype can be indicated by using several sequence-specific nucleic acid probes, each being specific for a particular allele. In one embodiment, a haplotype can be indicated by a single nucleic acid probe that is specific for the specific haplotype (i.e., hybridizes specifically to a DNA strand comprising the specific marker alleles characteristic of the haplotype). A sequence-specific probe can be directed to hybridize to genomic DNA, RNA, or cDNA. A "nucleic acid probe", as used herein, can be a DNA probe or an RNA probe that hybridizes to a complementary sequence. One of skill in the art would know how to design such a probe so that sequence specific hybridization will occur only if a particular allele is present in a genomic sequence from a test sample.

[0095] To diagnose a susceptibility to eosinophilia, asthma, myocardial infarction, and/or hypertension, or symptoms associated with eosinophilia, asthma, myocardial infarction, and/or hypertension, a hybridization sample can be formed by contacting the test sample containing an eosinophilia-, asthma-, myocardial infarction-, and/or hypertension-associated nucleic acid, such as a genomic DNA sample, with at least one nucleic acid probe. A non-limiting example of a probe for detecting mRNA or genomic DNA is a labeled nucleic acid probe that is capable of hybridizing to mRNA or genomic DNA sequences described herein. The nucleic acid probe can be, for example, a full-length nucleic acid molecule, or a portion thereof, such as an oligonucleotide of at least 10, 15, 30, 50, 100, 250 or 500 nucleotides in length that is sufficient to specifically hybridize under stringent conditions to appropriate mRNA or genomic DNA. For example, the nucleic acid probe can comprise all or a portion of the nucleotide sequence of a gene selected from the group consisting of ATP9A, ATXN2, BAX, CUX2, IL1RL1, IL33, LBH, LOC441108, PTPN11, RAD50, RAD51L1, SH2B3, SLC22A4, SNX6, TBC1D8, TNKS2, TNXB, BRAP, ACAD10, ALDH2, MAPKAPK5, and ERP29, and/or a LD block of any one of these genes, as described herein, optionally comprising at least one allele of a marker described herein, or at least one haplotype described herein, or the probe can be the complementary sequence of such a sequence. In a particular embodiment, the nucleic acid probe is a portion of the nucleotide sequence of a gene selected from the above group and/or the LD block of the gene, as described herein, optionally comprising at least one allele of a marker described herein, or at least one allele of a polymorphic marker of a haplotype comprising at least one polymorphic marker described herein, or the probe can be the complementary sequence of such a sequence. Other suitable probes for use in the diagnostic assays of the invention are described herein. Hybridization can be performed by methods well known to the person skilled in the art (see, e.g., Current Protocols in Molecular Biology, Ausubel et al., eds., John Wiley & Sons, including all supplements). In one embodiment, hybridization refers to specific hybridization, i.e., hybridization with no mismatches (exact hybridization). In one embodiment, the hybridization conditions for specific hybridization are high stringency.

[0096] Specific hybridization, if present, is detected using standard methods. If specific hybridization occurs between the nucleic acid probe and the nucleic acid in the test sample, then the sample contains the allele that is complementary to the nucleotide that is present in the nucleic acid probe. The process can be repeated for any markers of the invention, or markers that make up a haplotype of the invention, or multiple probes can be used concurrently to detect more than one marker alleles at a time. It is also possible to design a single probe containing more than one marker alleles of a particular haplotype (e.g., a probe containing alleles complementary to 2, 3, 4, 5 or all of the markers that make up a particular haplotype). Detection of the particular markers of the haplotype in the sample is indicative of the source of the sample having the particular haplotype (e.g., a haplotype) and therefore is susceptible to eosinophilia, asthma, myocardial infarction, and/or hypertension.

[0097] In one embodiment, a method utilizing a detection oligonucleotide probe comprising a fluorescent moiety or group at its 3' terminus and a quencher at its 5' terminus, and an enhancer oligonucleotide, is employed, as described by Kutyavin et al. (Nucleic Acid Res. 34:e128 (2006)). The fluorescent moiety can be Gig Harbor Green or Yakima Yellow, or other suitable fluorescent moieties. The detection probe is designed to hybridize to a short nucleotide sequence that includes the SNP polymorphism to be detected. Preferably, the SNP is anywhere from the terminal residue to -6 residues from the 3' end of the detection probe. The enhancer is a short oligonucleotide probe which hybridizes to the DNA template 3' relative to the detection probe. The probes are designed such that a single nucleotide gap exists between the detection probe and the enhancer nucleotide probe when both are bound to the template. The gap creates a synthetic a basic site that is recognized by an endonuclease, such as Endonuclease IV. The enzyme cleaves the dye off the fully complementary detection probe, but cannot cleave a detection probe containing a mismatch. Thus, by measuring the fluorescence of the released fluorescent moiety, assessment of the presence of a particular allele defined by nucleotide sequence of the detection probe can be performed.

[0098] The detection probe can be of any suitable size, although preferably the probe is relatively short. In one embodiment, the probe is from 5-100 nucleotides in length. In another embodiment, the probe is from 10-50 nucleotides in length, and in another embodiment, the probe is from 12-30 nucleotides in length. Other lengths of the probe are possible and within scope of the skill of the average person skilled in the art.

[0099] In a preferred embodiment, the DNA template containing the SNP polymorphism is amplified by Polymerase Chain Reaction (PCR) prior to detection. In such an embodiment, the amplified DNA serves as the template for the detection probe and the enhancer probe.

[0100] Certain embodiments of the detection probe, the enhancer probe, and/or the primers used for amplification of the template by PCR include the use of modified bases, including modified A and modified G. The use of modified bases can be useful for adjusting the melting temperature of the nucleotide molecule (probe and/or primer) to the template DNA, for example for increasing the melting temperature in regions containing a low percentage of G or C bases, in which modified A with the capability of forming three hydrogen bonds to its complementary T can be used, or for decreasing the melting temperature in regions containing a high percentage of G or C bases, for example by using modified G bases that form only two hydrogen bonds to their complementary C base in a double stranded DNA molecule. In a preferred embodiment, modified bases are used in the design of the detection nucleotide probe. Any modified base known to the skilled person can be selected in these methods, and the selection of suitable bases is well within the scope of the skilled person based on the teachings herein and known bases available from commercial sources as known to the skilled person.

[0101] In another hybridization method, Northern analysis (see Current Protocols in Molecular Biology, Ausubel et al., eds., John Wiley & Sons, supra) is used to identify the presence of a polymorphism associated with eosinophilia, asthma, myocardial infarction, and/or hypertension. For Northern analysis, a test sample of RNA is obtained from the subject by appropriate means. As described herein, specific hybridization of a nucleic acid probe to RNA from the subject is indicative of a particular allele complementary to the probe. For representative examples of use of nucleic acid probes, see, for example, U.S. Pat. Nos. 5,288,611 and 4,851,330.

[0102] Additionally, or alternatively, a peptide nucleic acid (PNA) probe can be used in addition to, or instead of, a nucleic acid probe in the hybridization methods described herein. A PNA is a DNA mimic having a peptide-like, inorganic backbone, such as N-(2-aminoethyl)glycine units, with an organic base (A, G, C, T or U) attached to the glycine nitrogen via a methylene carbonyl linker (see, for example, Nielsen et al., Bioconjug. Chem. 5:3-7 (1994)). The PNA probe can be designed to specifically hybridize to a molecule in a sample suspected of containing one or more of the marker alleles or haplotypes that are associated with eosinophilia, asthma, myocardial infarction, and/or hypertension. Hybridization of the PNA probe is thus diagnostic for eosinophilia, asthma, myocardial infarction, and/or hypertension.

[0103] In one embodiment of the invention, a test sample containing genomic DNA obtained from the subject is collected and the polymerase chain reaction (PCR) is used to amplify a fragment comprising one or more markers or haplotypes of the invention. As described herein, identification of a particular marker allele or haplotype associated with eosinophilia, asthma, myocardial infarction, and/or hypertension can be accomplished using a variety of methods (e.g., sequence analysis, analysis by restriction digestion, specific hybridization, single stranded conformation polymorphism assays (SSCP), electrophoretic analysis, etc.). In another embodiment, diagnosis is accomplished by expression analysis, for example using quantitative PCR (kinetic thermal cycling). This technique can, for example, utilize commercially available technologies, such as TaqMan.RTM. (Applied Biosystems, Foster City, Calif.). The technique can assess the presence of an alteration in the expression or composition of a polypeptide or splicing variant(s) that is encoded by a nucleic acid associated with eosinophilia, asthma, myocardial infarction, and/or hypertension. Further, the expression of the variant(s) can be quantified as physically or functionally different.

[0104] In another method of the invention, analysis by restriction digestion can be used to detect a particular allele if the allele results in the creation or elimination of a restriction site relative to a reference sequence. Restriction fragment length polymorphism (RFLP) analysis can be conducted, e.g., as described in Current Protocols in Molecular Biology, supra. The digestion pattern of the relevant DNA fragment indicates the presence or absence of the particular allele in the sample.

[0105] Sequence analysis can also be used to detect specific alleles or haplotypes associated with eosinophilia, asthma, myocardial infarction, and/or hypertension (e.g. the polymorphic markers of Table 3, and markers in linkage disequilibrium therewith). Therefore, in one embodiment, determination of the presence or absence of a particular marker allele or haplotype comprises sequence analysis of a test sample of DNA or RNA obtained from a subject or individual. PCR or other appropriate methods can be used to amplify a portion of a nucleic acid associated with eosinophilia, asthma, myocardial infarction, and/or hypertension and the presence of a specific allele can then be detected directly by sequencing the polymorphic site (or multiple polymorphic sites in a haplotype) of the genomic DNA in the sample.

[0106] Allele-specific oligonucleotides can also be used to detect the presence of a particular allele in a nucleic acid associated with eosinophilia, asthma, myocardial infarction, and/or hypertension (e.g. the polymorphic markers of Table 3, and markers in linkage disequilibrium therewith), through the use of dot-blot hybridization of amplified oligonucleotides with allele-specific oligonucleotide (ASO) probes (see, for example, Saiki et al., Nature 324:163-166 (1986)). An "allele-specific oligonucleotide" (also referred to herein as an "allele-specific oligonucleotide probe") is an oligonucleotide of approximately 10-50 base pairs or approximately 15-30 base pairs, that specifically hybridizes to a nucleic acid associated with eosinophilia, asthma, myocardial infarction, and/or hypertension and which contains a specific allele at a polymorphic site (e.g., a marker or haplotype as described herein). An allele-specific oligonucleotide probe that is specific for one or more particular a nucleic acid associated with eosinophilia, asthma, myocardial infarction, and/or hypertension can be prepared using standard methods (see, e.g., Current Protocols in Molecular Biology, supra). PCR can be used to amplify the desired region. The DNA containing the amplified region can be dot-blotted using standard methods (see, e.g., Current Protocols in Molecular Biology, supra), and the blot can be contacted with the oligonucleotide probe. The presence of specific hybridization of the probe to the amplified region can then be detected. Specific hybridization of an allele-specific oligonucleotide probe to DNA from the subject is indicative of a specific allele at a polymorphic site associated with a disease (see, e.g., Gibbs et al., Nucleic Acids Res. 17:2437-2448 (1989) and WO 93/22456).

[0107] With the addition of analogs such as locked nucleic acids (LNAs), the size of primers and probes can be reduced to as few as 8 bases. LNAs are a novel class of bicyclic DNA analogs in which the 2' and 4' positions in the furanose ring are joined via an O-methylene (oxy-LNA), S-methylene (thio-LNA), or amino methylene (amino-LNA) moiety. Common to all of these LNA variants is an affinity toward complementary nucleic acids, which is by far the highest reported for a DNA analog. For example, particular all oxy-LNA nonamers have been shown to have melting temperatures (Tm) of 64.degree. C. and 74.degree. C. when in complex with complementary DNA or RNA, respectively, as opposed to 28.degree. C. for both DNA and RNA for the corresponding DNA nonamer. Substantial increases in Tm are also obtained when LNA monomers are used in combination with standard DNA or RNA monomers. For primers and probes, depending on where the LNA monomers are included (e.g., the 3' end, the 5' end, or in the middle), the Tm could be increased considerably.

[0108] In another embodiment, arrays of oligonucleotide probes that are complementary to target nucleic acid sequence segments from a subject, can be used to identify polymorphisms in a nucleic acid associated with eosinophilia, asthma, myocardial infarction, and/or hypertension (e.g. the polymorphic markers of Table 3 and markers in linkage disequilibrium therewith). For example, an oligonucleotide array can be used. Oligonucleotide arrays typically comprise a plurality of different oligonucleotide probes that are coupled to a surface of a substrate in different known locations. These arrays can generally be produced using mechanical synthesis methods or light directed synthesis methods that incorporate a combination of photolithographic methods and solid phase oligonucleotide synthesis methods, or by other methods known to the person skilled in the art (see, e.g., Bier et al., Adv Biochem Eng Biotechnol 109:433-53 (2008); Hoheisel, Nat Rev Genet 7:200-10 (2006); Fan et al., Methods Enzymol 410:57-73 (2006); Raqoussis & Elvidge, Expert Rev Mol Diagn 6:145-52 (2006); Mockler et al., Genomics 85:1-15 (2005), and references cited therein, the entire teachings of each of which are incorporated by reference herein). Many additional descriptions of the preparation and use of oligonucleotide arrays for detection of polymorphisms can be found, for example, in U.S. Pat. No. 6,858,394, U.S. Pat. No. 6,429,027, U.S. Pat. No. 5,445,934, U.S. Pat. No. 5,700,637, U.S. Pat. No. 5,744,305, U.S. Pat. No. 5,945,334, U.S. Pat. No. 6,054,270, U.S. Pat. No. 6,300,063, U.S. Pat. No. 6,733,977, U.S. Pat. No. 7,364,858, EP 619 321, and EP 373 203, the entire teachings of which are incorporated by reference herein.

[0109] Also, standard techniques for genotyping can be used, such as fluorescence-based techniques (e.g., Chen et al., Genome Res. 9(5): 492-98 (1999); Kutyavin et al., Nucleic Acid Res. 34:e128 (2006)), utilizing PCR, LCR, Nested PCR and other techniques for nucleic acid amplification. Specific commercial methodologies available for SNP genotyping include, but are not limited to, TaqMan genotyping assays and SNPlex platforms (Applied Biosystems), gel electrophoresis (Applied Biosystems), mass spectrometry (e.g., MassARRAY system from Sequenom), minisequencing methods, real-time PCR, Bio-Plex system (BioRad), CEQ and SNPstream systems (Beckman), array hybridization technology (e.g., Affymetrix GeneChip; Perlegen), BeadArray Technologies (e.g., Illumina GoldenGate and Infinium assays), array tag technology (e.g., Parallele), and endonuclease-based fluorescence hybridization technology (Invader; Third Wave). Some of the available array platforms, including Affymetrix SNP Array 6.0 and Illumina CNV370-Duo and 1M BeadChips, include SNPs that tag certain copy number variations (CNVs). This allows detection of CNVs via surrogate SNPs included in these platforms. Thus, by use of these or other methods available to the person skilled in the art, one or more alleles at polymorphic markers, including microsatellites, SNPs or other types of polymorphic markers, can be identified.

[0110] The direct sequence analysis can be of the nucleic acid of a biological sample obtained from the human individual for which a susceptibility is being determined. The biological sample can be any sample containing nucleic acid (e.g., genomic DNA) obtained from the human individual. For example, the biological sample can be a blood sample, a serum sample, a leukapheresis sample, an amniotic fluid sample, a cerbrospinal fluid sample, a hair sample, a tissue sample from skin, muscle, buccal, or conjuctival mucosa, placenta, gastrointestinal tract, or other organs, a semen sample, a urine sample, a saliva sample, a nail sample, a tooth sample, and the like.

[0111] In a specific aspect of the invention, obtaining nucleic acid sequence data comprises obtaining nucleic acid sequence information from a preexisting record, e.g., a preexisting medical record comprising genotype information of the human individual. For example, direct sequence analysis of the allele of the polymorphic marker can be accomplished by mining a pre-existing genotype dataset for the sequence of the allele of the polymorphic marker.

[0112] Indirect Analysis

[0113] Alternatively, the nucleic acid sequence data may be obtained through indirect analysis of the nucleic acid sequence of the allele of the polymorphic marker. For example, the allele could be one which leads to the expression of a variant protein comprising an altered amino acid sequence, as compared to the non-variant (e.g., wild-type) protein, due to one or more amino acid substitutions, deletions, or insertions, or truncation (due to, e.g., splice variation). For example, the allele could be one of the A allele of rs272893, which leads to a substitution of Ile at position 306 of GenBank Accession No. NP_003050 with Thr, the C allele of rs1050152, which leads to a substitution of Leu at position 503 of the amino acid sequence of GenBank Accession No. NP_003050 with Phe, or the T allele of rs3184504, which leads to a substitution of Trp at position 262 of GenBank Accession No. NP_005466 with Arg. In this instance, nucleic acid sequence data about the allele of the polymorphic marker can be obtained through detection of the amino acid substitution of the variant protein. Methods of detecting variant proteins are known in the art. For example, direct amino acid sequencing of the variant protein followed by comparison to a reference amino acid sequence can be used. Alternatively, SDS-PAGE followed by gel staining can be used to detect variant proteins of different molecular weights. Also, Immunoassays, e.g., immunofluorescent immunoassays, immunoprecipitations, radioimmunoasays, ELISA, and Western blotting, in which an antibody specific for an epitope comprising the variant sequence among the variant protein and non-variant or wild-type protein can be used.

[0114] It is also possible, for example, for the variant protein to demonstrate altered (e.g., upregulated or downregulated) biological activity, in comparison to the non-variant or wild-type protein. The biological activity can be, for example, a binding activity or enzymatic activity. In this instance, nucleic acid sequence data about the allele of the polymorphic marker can be obtained through detection of the altered biological activity. Methods of detecting binding activity and enzymatic activity are known in the art and include, for instance, ELISA, competitive binding assays, quantitative binding assays using instruments such as, for example, a Biacore.RTM. 3000 instrument, chromatographic assays, e.g., HPLC and TLC.

[0115] Alternatively or additionally, the polymorphic variant (the allele of the polymorphic marker) could lead to an altered expression level, e.g., an increased expression level of an mRNA or protein, a decreased expression level of an mRNA or protein. Nucleic acid sequence data about the allele of the polymorphic marker can, in these instances, be obtained through detection of the altered expression level. Methods of detecting expression levels are known in the art. For example, ELISA, radioimmunoassays, immunofluorescence, and Western blotting can be used to compare the expression of protein levels. Alternatively, Northern blotting can be used to compare the levels of mRNA. These processes are described in Sambrook et al., Molecular Cloning: A Laboratory Manual, 3.sup.rd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. (2001).

[0116] The indirect sequence analysis can be of the nucleic acid (e.g., DNA, mRNA) or protein of a biological sample obtained from the human individual for which a susceptibility is being determined. The biological sample can be any nucleic acid or protein containing sample obtained from the human individual. For example, the biological sample can be any of the biological samples described herein.

[0117] In view of the foregoing, analyzing the sequence of the at least one polymorphic marker can comprise determining the presence or absence of at least one allele of the at least one polymorphic marker, or it can comprise analyzing the sequence of the polymorphic marker of a particular sample. Further, analyzing the sequence of the at least one polymorphic marker can comprise determining the presence or absence of an amino acid substitution in the amino acid sequence encoded by the polymorphic marker of at least one gene of the group, or it can comprise obtaining a biological sample from the human individual and analyzing the amino acid sequence encoded by at least one gene of the group.

[0118] Linkage Disequilibrium

[0119] The nucleic acid sequence data may be obtained through other means of indirect analysis of the nucleic acid sequence of the allele of the polymorphic marker. For example, obtaining the nucleic acid data can comprise identifying at least one allele of a marker in linkage disequilibrium with at least one polymorphic marker associated with eosinophilia, asthma, myocardial infarction, and/or hypertension, as described herein.

[0120] Linkage Disequilibrium (LD) refers to a non-random assortment of two genetic elements. For example, if a particular genetic element (e.g., an allele of a polymorphic marker, or a haplotype) occurs in a population at a frequency of 0.50 (50%) and another element occurs at a frequency of 0.50 (50%), then the predicted occurrance of a person's having both elements is 0.25 (25%), assuming a random distribution of the elements. However, if it is discovered that the two elements occur together at a frequency higher than 0.25, then the elements are said to be in linkage disequilibrium, since they tend to be inherited together at a higher rate than what their independent frequencies of occurrence (e.g., allele or haplotype frequencies) would predict. Roughly speaking, LD is generally correlated with the frequency of recombination events between the two elements. Allele or haplotype frequencies can be determined in a population by genotyping individuals in a population and determining the frequency of the occurence of each allele or haplotype in the population. For populations of diploids, e.g., human populations, individuals will typically have two alleles for each genetic element (e.g., a marker, haplotype or gene).

[0121] Many different measures have been proposed for assessing the strength of linkage disequilibrium (LD; reviewed in Devlin, B. & Risch, N., Genomics 29:311-22 (1995)). Most capture the strength of association between pairs of biallelic sites. Two important pairwise measures of LD are r.sup.2 (sometimes denoted .DELTA..sup.2) and |D'| (Lewontin, R., Genetics 49:49-67 (1964); Hill, W. G. & Robertson, A. Theor. Appl. Genet. 22:226-231 (1968)). Both measures range from 0 (no disequilibrium) to 1 (complete' disequilibrium), but their interpretation is slightly different. |D'| is defined in such a way that it is equal to 1 if just two or three of the possible haplotypes are present, and it is <1 if all four possible haplotypes are present. Therefore, a value of |D'| that is <1 indicates that historical recombination may have occurred between two sites (recurrent mutation can also cause |D'| to be <1, but for single nucleotide polymorphisms (SNPs) this is usually regarded as being less likely than recombination). The measure r.sup.2 represents the statistical correlation between two sites, and takes the value of 1 if only two haplotypes are present.

[0122] The r.sup.2 measure is arguably the most relevant measure for association mapping, because there is a simple inverse relationship between r.sup.2 and the sample size required to detect association between susceptibility loci and SNPs. These measures are defined for pairs of sites, but for some applications a determination of how strong LD is across an entire region that contains many polymorphic sites might be desirable (e.g., testing whether the strength of LD differs significantly among loci or across populations, or whether there is more or less LD in a region than predicted under a particular model). Measuring LD across a region is not straightforward, but one approach is to use the measure r, which was developed in population genetics. Roughly speaking, r measures how much recombination would be required under a particular population model to generate the LD that is seen in the data. This type of method can potentially also provide a statistically rigorous approach to the problem of determining whether LD data provide evidence for the presence of recombination hotspots.

[0123] For the methods described herein, a significant r.sup.2 value can be at least 0.1 such as at least 0.1, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5, 0.55, 0.6, 0.65, 0.7, 0.75, 0.8, 0.85, 0.9, 0.91, 0.92, 0.93, 0.94, 0.95, 0.96, 0.97, 0.98, 0.99 or 1.0. In one specific embodiment of invention, the significant r.sup.2 value can be at least 0.2. Alternatively, linkage disequilibrium as described herein, refers to linkage disequilibrium characterized by values of |D'| of at least 0.2, such as 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.85, 0.9, 0.95, 0.96, 0.97, 0.98, 0.99. Thus, linkage disequilibrium represents a correlation between alleles of distinct markers. It is measured by correlation coefficient or |D'| (r.sup.2 up to 1.0 and |D'| up to 1.0). Linkage disequilibrium can be determined in a single human population, as defined herein, or it can be determined in a collection of samples comprising individuals from more than one human population. In one embodiment of the invention, LD is determined in a sample from one or more of the HapMap populations. These include samples from the Yoruba people of Ibadan, Nigeria (YRI), samples from individuals from the Tokyo area in Japan (JPT), samples from individuals Beijing, China (CHB), and samples from U.S. residents with northern and western European ancestry (CEU), as described (The International HapMap Consortium, Nature 426:789-796 (2003)). In one such embodiment, LD is determined in the Caucasian CEU population of the HapMap samples. In another embodiment, LD is determined in the African YRI population. In yet another embodiment, LD is determined in samples from the Icelandic population.

[0124] If all polymorphisms in the genome were independent at the population level (i.e., no LD between polymorphisms), then every single one of them would need to be investigated in association studies, to assess all different polymorphic states. However, due to linkage disequilibrium between polymorphisms, tightly linked polymorphisms are strongly correlated, which reduces the number of polymorphisms that need to be investigated in an association study to observe a significant association. Another consequence of LD is that many polymorphisms may give an association signal due to the fact that these polymorphisms are strongly correlated.

[0125] Genomic LD maps have been generated across the genome, and such LD maps have been proposed to serve as framework for mapping disease-genes (Risch, N. & Merkiangas, K, Science 273:1516-1517 (1996); Maniatis, N., et al., Proc Natl Acad Sci USA 99:2228-2233 (2002); Reich, D E et al, Nature 411:199-204 (2001)).

[0126] It is now established that many portions of the human genome can be broken into series of discrete haplotype blocks containing a few common haplotypes; for these blocks, linkage disequilibrium data provides little evidence indicating recombination (see, e.g., Wall., J. D. and Pritchard, J. K., Nature Reviews Genetics 4:587-597 (2003); Daly, M. et al., Nature Genet. 29:229-232 (2001); Gabriel, S. B. et al., Science 296:2225-2229 (2002); Patil, N. et al., Science 294:1719-1723 (2001); Dawson, E. et al., Nature 418:544-548 (2002); Phillips, M. S. et al., Nature Genet. 33:382-387 (2003)).

[0127] There are two main methods for defining these haplotype blocks: blocks can be defined as regions of DNA that have limited haplotype diversity (see, e.g., Daly, M. et al., Nature Genet. 29:229-232 (2001); Patil, N. et al., Science 294:1719-1723 (2001); Dawson, E. et al., Nature 418:544-548 (2002); Zhang, K. et al., Proc. Natl. Acad. Sci. USA 99:7335-7339 (2002)), or as regions between transition zones having extensive historical recombination, identified using linkage disequilibrium (see, e.g., Gabriel, S. B. et al., Science 296:2225-2229 (2002); Phillips, M. S. et al., Nature Genet. 33:382-387 (2003); Wang, N. et al., Am. J. Hum. Genet. 71:1227-1234 (2002); Stumpf, M. P., and Goldstein, D. B., Curr. Biol. 13:1-8 (2003)). More recently, a fine-scale map of recombination rates and corresponding hotspots across the human genome has been generated (Myers, S., et al., Science 310:321-32324 (2005); Myers, S. et al., Biochem Soc Trans 34:526530 (2006)). The map reveals the enormous variation in recombination across the genome, with recombination rates as high as 10-60 cM/Mb in hotspots, while closer to 0 in intervening regions, which thus represent regions of limited haplotype diversity and high LD. The map can therefore be used to define haplotype blocks/LD blocks as regions flanked by recombination hotspots. As used herein, the terms "haplotype block" or "LD block" includes blocks defined by any of the above described characteristics, or other alternative methods used by the person skilled in the art to define such regions.

[0128] Haplotype blocks (LD blocks) can be used to map associations between phenotype and haplotype status, using single markers or haplotypes comprising a plurality of markers. The main haplotypes can be identified in each haplotype block, and then a set of "tagging" SNPs or markers (the smallest set of SNPs or markers needed to distinguish among the haplotypes) can then be identified. These tagging SNPs or markers can then be used in assessment of samples from groups of individuals, in order to identify association between phenotype and haplotype. If desired, neighboring haplotype blocks can be assessed concurrently, as there may also exist linkage disequilibrium among the haplotype blocks.

[0129] It has thus become apparent that for any given observed association to a polymorphic marker in the genome, it is likely that additional markers in the genome also show association. This is a natural consequence of the uneven distribution of LD across the genome, as observed by the large variation in recombination rates. The markers used to detect association thus in a sense represent "tags" for a genomic region (i.e., a haplotype block or LD block) that is associating with a given disease or trait, and as such are useful for use in the methods and kits of the invention. One or more causative (functional) variants or mutations may reside within the region found to be associating to the disease or trait. The functional variant may be another SNP, a tandem repeat polymorphism (such as a minisatellite or a microsatellite), a transposable element, or a copy number variation, such as an inversion, deletion or insertion. Such variants in LD with other variants used to detect an association to a disease or trait (e.g., the variants described herein to be associated with risk of eosinophilia, asthma, myocardial infarction, and/or hypertension) may confer a higher relative risk (RR) or odds ratio (OR) than observed for the tagging markers used to detect the association. The invention thus refers to the markers used for detecting association to the disease, as described herein, as well as markers in linkage disequilibrium with the markers. Thus, in certain embodiments of the invention, markers that are in LD with the markers and/or haplotypes of the invention, as described herein, may be used as surrogate markers. The surrogate markers have in one embodiment relative risk (RR) and/or odds ratio (OR) values smaller than for the markers or haplotypes initially found to be associating with the disease, as described herein. In other embodiments, the surrogate markers have RR or OR values greater than those initially determined for the markers initially found to be associating with the disease, as described herein. An example of such an embodiment would be a rare, or relatively rare (<10% allelic population frequency) variant in LD with a more common variant (>10% population frequency) initially found to be associating with the disease, such as the variants described herein. Identifying and using such markers for detecting the association discovered by the inventors as described herein can be performed by routine methods well known to the person skilled in the art, and are therefore within the scope of the invention.

[0130] In view of the foregoing, the marker in linkage disequilibrium with a polymorphic marker associated with eosinophilia, asthma, myocardial infarction, and/or hypertension may be one of the surrogate markers listed in Table 2. The markers were selected using data for the Caucasian CEU samples from the HapMap dataset (http://www.hapmap.org).

TABLE-US-00002 TABLE 2 surrogate marker anchor marker D' r2 chromosome position rs12617902 rs12619285 1 0.239669 C02 213497136 rs4672665 rs12619285 1 0.239669 C02 213498708 rs16849446 rs12619285 1 0.244447 C02 213500207 rs975381 rs12619285 1 0.252874 C02 213524876 rs2170572 rs12619285 1 1 C02 213525464 rs7560454 rs12619285 1 1 C02 213526823 rs12619285 rs12619285 1 1 C02 213532290 rs10189498 rs12619285 1 1 C02 213534396 rs6750754 rs12619285 1 1 C02 213538432 rs6740906 rs12619285 1 0.883833 C02 213540967 rs1482577 rs12619285 1 0.885057 C02 213543369 rs13022407 rs12619285 1 0.885057 C02 213544451 rs10199053 rs12619285 1 0.204244 C02 213545970 rs17276404 rs12619285 1 0.568966 C02 213554080 rs7588793 rs12619285 1 0.249753 C02 213558644 rs12616485 rs12619285 1 0.366874 C02 213558845 rs12613560 rs12619285 1 0.568966 C02 213559032 rs4467215 rs12619285 1 0.568966 C02 213559209 rs2371786 rs12619285 1 0.632184 C02 213559439 rs10932456 rs12619285 1 0.549192 C02 213561500 rs4233991 rs12619285 1 0.358901 C02 213562422 rs7569831 rs12619285 1 0.350867 C02 213562601 rs7573040 rs12619285 1 0.350867 C02 213563109 rs12470672 rs12619285 1 0.346847 C02 213563300 rs13405747 rs12619285 1 0.22366 C02 213563735 rs7576646 rs12619285 1 0.496021 C02 213563962 rs7576850 rs12619285 1 0.211638 C02 213564116 rs7603237 rs12619285 1 0.22366 C02 213564244 rs7603346 rs12619285 1 0.22366 C02 213564317 rs7577413 rs12619285 1 0.331897 C02 213564411 rs6734978 rs12619285 1 0.219601 C02 213566314 rs4673714 rs12619285 1 0.219601 C02 213566402 rs12620781 rs12619285 1 0.219601 C02 213567232 rs16849550 rs12619285 1 0.219601 C02 213568803 rs1871946 rs12619285 0.830541 0.319792 C02 213587652 rs10932460 rs12619285 0.809352 0.292774 C02 213608717 rs13417169 rs12619285 0.791871 0.270251 C02 213611882 rs12612034 rs12619285 0.819032 0.290687 C02 213619366 rs1922291 rs1420101 0.841424 0.200343 C02 102195249 rs6743219 rs1420101 0.843689 0.205319 C02 102198143 rs10167431 rs1420101 0.807276 0.249429 C02 102219234 rs10200410 rs1420101 0.809741 0.239147 C02 102237303 rs1345301 rs1420101 0.809741 0.239147 C02 102242019 rs2310243 rs1420101 0.809741 0.239147 C02 102243992 rs13405355 rs1420101 0.812212 0.24568 C02 102244638 rs12475055 rs1420101 0.809741 0.239147 C02 102245323 rs11693697 rs1420101 0.660435 0.235669 C02 102282094 rs4399750 rs1420101 1 0.645931 C02 102284220 rs4090473 rs1420101 1 0.645931 C02 102289419 rs11685424 rs1420101 0.953846 0.587682 C02 102293413 rs1558622 rs1420101 1 0.645931 C02 102296579 rs10189711 rs1420101 1 0.645931 C02 102297313 rs12712135 rs1420101 1 0.624096 C02 102297380 rs953934 rs1420101 1 0.624096 C02 102298725 rs950880 rs1420101 1 0.961953 C02 102298994 rs11123918 rs1420101 1 0.671946 C02 102301669 rs10182639 rs1420101 1 0.680256 C02 102302237 rs11690443 rs1420101 1 0.680256 C02 102302563 rs974389 rs1420101 1 0.645931 C02 102303413 rs4142132 rs1420101 1 0.659179 C02 102303914 rs13001325 rs1420101 1 0.961039 C02 102305468 rs1420088 rs1420101 1 0.64268 C02 102305866 rs11123920 rs1420101 1 0.639369 C02 102306265 rs6706844 rs1420101 1 0.645931 C02 102306844 rs12996772 rs1420101 1 0.645931 C02 102313633 rs1420102 rs1420101 1 0.64268 C02 102315251 rs12466380 rs1420101 1 0.64268 C02 102315371 rs12479210 rs1420101 1 0.961501 C02 102315593 rs13019081 rs1420101 1 0.961501 C02 102317254 rs1997467 rs1420101 1 0.64268 C02 102317505 rs1997466 rs1420101 1 0.64268 C02 102317899 rs1362350 rs1420101 1 0.64268 C02 102318230 rs1362349 rs1420101 1 0.665569 C02 102318404 rs17026974 rs1420101 1 0.850885 C02 102318792 rs12712141 rs1420101 1 0.662404 C02 102319499 rs873022 rs1420101 1 0.850885 C02 102322115 rs3771177 rs1420101 1 0.850885 C02 102322292 rs3732129 rs1420101 1 0.850885 C02 102323964 rs1420101 rs1420101 1 1 C02 102324148 rs12905 rs1420101 1 0.850885 C02 102326439 rs3821204 rs1420101 0.956909 0.812486 C02 102326713 rs12712142 rs1420101 1 0.796149 C02 102327016 rs6543119 rs1420101 1 0.796149 C02 102329504 rs13017455 rs1420101 1 0.796149 C02 102331174 rs17027006 rs1420101 0.956909 0.812486 C02 102331764 rs12469506 rs1420101 0.958647 0.848874 C02 102332303 rs1921622 rs1420101 1 0.39006 C02 102332499 rs1861245 rs1420101 1 0.297189 C02 102333338 rs13424006 rs1420101 1 0.297189 C02 102333668 rs6751967 rs1420101 1 0.297189 C02 102333845 rs6749114 rs1420101 1 0.297189 C02 102334019 rs11123923 rs1420101 1 0.798263 C02 102334276 rs4988955 rs1420101 1 0.297189 C02 102334360 rs4988956 rs1420101 1 0.297189 C02 102334439 rs4988957 rs1420101 1 0.297189 C02 102334507 rs10204137 rs1420101 1 0.297189 C02 102334644 rs4988958 rs1420101 1 0.297189 C02 102334717 rs10192157 rs1420101 1 0.297189 C02 102334788 rs10206753 rs1420101 1 0.297189 C02 102334794 rs7603730 rs1420101 1 0.297189 C02 102340803 rs12998521 rs1420101 1 0.798263 C02 102340849 rs10170583 rs1420101 0.925939 0.264046 C02 102341196 rs10176664 rs1420101 1 0.297189 C02 102342604 rs3755276 rs1420101 1 0.297189 C02 102344891 rs2287037 rs1420101 1 0.798263 C02 102345460 rs1362348 rs1420101 1 0.297189 C02 102351056 rs3771172 rs1420101 0.957414 0.812936 C02 102352244 rs3771171 rs1420101 1 0.850885 C02 102352382 rs2160202 rs1420101 1 0.846939 C02 102352586 rs3771166 rs1420101 1 0.275825 C02 102352654 rs1974675 rs1420101 1 0.271038 C02 102352807 rs10439410 rs1420101 0.764681 0.249239 C02 102357220 rs6758936 rs1420101 0.761508 0.241829 C02 102357801 rs2041739 rs1420101 0.764681 0.249239 C02 102360765 rs17027037 rs1420101 1 0.850885 C02 102361316 rs2080289 rs1420101 1 0.850885 C02 102361452 rs10208196 rs1420101 0.762981 0.245226 C02 102362777 rs11683700 rs1420101 1 0.846939 C02 102363237 rs3213732 rs1420101 0.761508 0.241829 C02 102364711 rs6760621 rs1420101 0.741467 0.222039 C02 102366384 rs1035130 rs1420101 1 0.850885 C02 102367834 rs2241116 rs1420101 1 0.651264 C02 102369697 rs6706002 rs1420101 0.761508 0.241829 C02 102372536 rs4851570 rs1420101 1 0.850885 C02 102372819 rs6749014 rs1420101 0.756416 0.241978 C02 102372880 rs1420097 rs1420101 0.761508 0.241829 C02 102375786 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rs2269426 1 0.289532 C06 32205961 rs9267803 rs2269426 1 0.560811 C06 32209740 rs4713505 rs2269426 1 0.560811 C06 32212979 rs4713506 rs2269426 1 0.531903 C06 32221958 rs1053924 rs2269426 1 0.364732 C06 32228693 rs3134950 rs2269426 0.947931 0.457793 C06 32235455 rs2269424 rs2269426 0.916025 0.332172 C06 32240211 rs1061808 rs2269426 0.897346 0.424223 C06 32244525 rs1061807 rs2269426 0.916025 0.332172 C06 32244816 rs2269423 rs2269426 0.897346 0.424223 C06 32253685 rs1035798 rs2269426 0.916025 0.332172 C06 32259200 rs1800624 rs2269426 0.836383 0.295681 C06 32260365 rs2071280 rs2269426 0.66839 0.290949 C06 32272847 rs2071279 rs2269426 0.717188 0.329274 C06 32272852 rs9267820 rs2269426 0.655661 0.251406 C06 32273561 rs9267821 rs2269426 0.665133 0.289162 C06 32277552 rs2071287 rs2269426 0.62681 0.272032 C06 32278411 rs2071277 rs2269426 0.62681 0.272032 C06 32279661 rs9267833 rs2269426 0.66839 0.290949 C06 32285878 rs2071286 rs2269426 0.686812 0.26454 C06 32287874 rs3134799 rs2269426 0.691808 0.32146 C06 32292199 rs3134798 rs2269426 0.935285 0.298199 C06 32292683 rs436388 rs2269426 0.767869 0.322591 C06 32294242 rs444472 rs2269426 0.57282 0.258136 C06 32294704 rs394657 rs2269426 0.592068 0.260445 C06 32295001 rs429853 rs2269426 0.58508 0.245487 C06 32295180 rs431722 rs2269426 0.793218 0.331481 C06 32295700 rs430916 rs2269426 0.654276 0.26561 C06 32296077 rs423023 rs2269426 0.733107 0.457304 C06 32296275 rs422951 rs2269426 0.551882 0.234519 C06 32296361 rs520803 rs2269426 0.729036 0.465751 C06 32296581 rs520692 rs2269426 0.727926 0.446988 C06 32296618 rs415929 rs2269426 0.733107 0.457304 C06 32297010 rs45855 rs2269426 0.733107 0.457304 C06 32297459 rs7772031 rs9494145 0.817464 0.204929 C06 135301427 rs7754722 rs9494145 0.816562 0.213236 C06 135301996 rs11758774 rs9494145 0.8209 0.215491 C06 135425482 rs1547247 rs9494145 0.788225 0.314304 C06 135432529 rs9376090 rs9494145 0.808209 0.470173 C06 135452921 rs7775698 rs9494145 0.865656 0.542497 C06 135460328 rs7776054 rs9494145 0.86433 0.517245 C06 135460609 rs9399137 rs9494145 0.870968 0.522581 C06 135460711 rs9389268 rs9494145 0.870968 0.522581 C06 135461324 rs11759553 rs9494145 0.935188 0.602487 C06 135463989 rs9373124 rs9494145 0.871608 0.547147 C06 135464902 rs4895440 rs9494145 1 0.657143 C06 135468251

rs4895441 rs9494145 1 0.688889 C06 135468266 rs9376092 rs9494145 1 0.654676 C06 135468837 rs9389269 rs9494145 1 0.686567 C06 135468852 rs9402686 rs9494145 0.935917 0.633373 C06 135469510 rs10484494 rs9494145 1 0.263158 C06 135471786 rs6920211 rs9494145 1 0.8 C06 135473011 rs11154 rs9494145 1 0.843478 C06 135473333 rs9494145 rs9494145 1 1 C06 135474245 rs7766963 rs9494145 1 0.295139 C06 135474576 rs9483788 rs9494145 1 0.889908 C06 135477194 rs2026937 rs9494145 0.910886 0.224511 C06 135480956 rs6934903 rs9494145 0.907692 0.500503 C06 135493257 rs6569992 rs9494145 0.898807 0.508487 C06 135493845 rs9389272 rs9494145 0.906198 0.499294 C06 135501530 rs17064262 rs9494145 0.899075 0.449495 C06 135507167 rs6924687 rs9494145 0.9 0.45 C06 135509214 rs9494154 rs9494145 0.9 0.45 C06 135509698 rs17706858 rs9494145 0.8 0.355556 C06 135526787 rs7757054 rs9494145 0.7 0.272222 C06 135529307 rs11965277 rs9494145 0.76 0.262545 C06 135539525 rs1022506 rs9494145 0.76 0.262545 C06 135553280 rs11154794 rs9494145 0.76 0.262545 C06 135557141 rs12663543 rs9494145 0.767821 0.280928 C06 135559307 rs12660713 rs9494145 0.76 0.262545 C06 135559689 rs6920829 rs9494145 0.76 0.262545 C06 135561193 rs3752383 rs9494145 0.858244 0.300534 C06 135564448 rs6936293 rs9494145 0.76 0.262545 C06 135577714 rs7738267 rs9494145 0.672727 0.228357 C06 135578886 rs10095228 rs748065 0.830888 0.486122 C08 21724187 rs17427894 rs748065 1 0.245283 C08 21728250 rs10096540 rs748065 0.90944 0.56481 C08 21729036 rs17060577 rs748065 1 0.440353 C08 21729708 rs17615281 rs748065 1 0.245283 C08 21730683 rs10107501 rs748065 0.89993 0.549939 C08 21731204 rs17060585 rs748065 1 1 C08 21733604 rs748065 rs748065 1 1 C08 21734049 rs7014068 rs748065 1 1 C08 21736295 rs10107278 rs748065 1 1 C08 21737035 rs922504 rs748065 1 0.636364 C08 21737990 rs4872494 rs748065 1 0.964222 C08 21747560 rs4872500 rs748065 1 0.615385 C08 21748400 rs17060602 rs748065 1 0.897436 C08 21749167 rs7464201 rs748065 1 0.64018 C08 21749954 rs369756 rs3939286 0.714032 0.287121 C09 6136441 rs450108 rs3939286 1 0.435398 C09 6143485 rs1116795 rs3939286 1 0.503722 C09 6145226 rs2225537 rs3939286 1 0.490446 C09 6150578 rs10124250 rs3939286 1 0.503722 C09 6151686 rs10119713 rs3939286 1 0.503722 C09 6153823 rs2079 rs3939286 0.514984 0.214206 C09 6156653 rs2381413 rs3939286 1 0.471154 C09 6157017 rs7032572 rs3939286 1 0.503876 C09 6162380 rs10815362 rs3939286 0.904609 0.249384 C09 6163798 rs2890704 rs3939286 0.907589 0.252485 C09 6174165 rs1929996 rs3939286 1 0.728507 C09 6177636 rs10758748 rs3939286 1 0.285714 C09 6177862 rs4742166 rs3939286 1 0.72561 C09 6178124 rs1412426 rs3939286 1 0.728507 C09 6178652 rs1412425 rs3939286 1 0.72561 C09 6178740 rs1342326 rs3939286 1 0.513678 C09 6180076 rs2095044 rs3939286 1 0.964222 C09 6182796 rs2381416 rs3939286 1 0.93007 C09 6183455 rs10815370 rs3939286 1 0.680697 C09 6184831 rs1888909 rs3939286 1 0.964222 C09 6187392 rs2150970 rs3939286 0.907589 0.252485 C09 6191364 rs7046661 rs3939286 1 0.680697 C09 6199199 rs992969 rs3939286 1 1 C09 6199697 rs3939286 rs3939286 1 1 C09 6200099 rs928413 rs3939286 1 1 C09 6203387 rs7848215 rs3939286 1 0.93007 C09 6203468 rs2066362 rs3939286 0.881657 0.399291 C09 6209176 rs12339348 rs3939286 0.60752 0.249249 C09 6223082 rs17582919 rs3939286 0.603368 0.245854 C09 6223376 rs10975507 rs3939286 0.60752 0.249249 C09 6226977 rs17498196 rs3939286 0.60752 0.249249 C09 6227547 rs10815393 rs3939286 0.60752 0.249249 C09 6230324 rs7019575 rs3939286 0.741062 0.27663 C09 6233935 rs744567 rs3939286 0.562538 0.213706 C09 6282602 rs4742211 rs3939286 0.641365 0.223294 C09 6525500 rs2106409 rs3184504 0.598939 0.271257 C12 109870381 rs4766521 rs3184504 0.69865 0.304042 C12 109871344 rs3919447 rs3184504 0.652019 0.306966 C12 109876182 rs4766522 rs3184504 0.600811 0.275346 C12 109877902 rs2106407 rs3184504 0.598939 0.271257 C12 109878710 rs2106406 rs3184504 0.600811 0.275346 C12 109878767 rs12425190 rs3184504 0.600811 0.275346 C12 109879312 rs2339706 rs3184504 0.600811 0.275346 C12 109880802 rs4509829 rs3184504 0.600811 0.275346 C12 109880996 rs11838131 rs3184504 0.600811 0.275346 C12 109881341 rs12818548 rs3184504 0.663295 0.311195 C12 109882481 rs4766523 rs3184504 0.598939 0.271257 C12 109883562 rs4766524 rs3184504 0.597304 0.272141 C12 109883829 rs7961663 rs3184504 0.600811 0.275346 C12 109884154 rs7961935 rs3184504 0.600811 0.275346 C12 109884389 rs7978821 rs3184504 0.600811 0.275346 C12 109884499 rs4766526 rs3184504 0.667865 0.318268 C12 109885699 rs4766442 rs3184504 0.600811 0.275346 C12 109886076 rs4766443 rs3184504 0.549529 0.230041 C12 109886181 rs12815195 rs3184504 0.600811 0.275346 C12 109886746 rs4766527 rs3184504 0.600811 0.275346 C12 109889853 rs12814105 rs3184504 0.661611 0.314137 C12 109891219 rs991817 rs3184504 0.600811 0.275346 C12 109894920 rs11065784 rs3184504 0.667865 0.318268 C12 109896846 rs7968960 rs3184504 0.63855 0.343686 C12 109910998 rs4378452 rs3184504 0.663217 0.360651 C12 109988416 rs10774613 rs3184504 0.550714 0.2646 C12 110030548 rs1265566 rs3184504 0.867628 0.259762 C12 110200759 rs7970490 rs3184504 0.848231 0.221355 C12 110240821 rs3847953 rs3184504 0.924784 0.263113 C12 110249847 rs6490055 rs3184504 0.911843 0.208663 C12 110253356 rs11065884 rs3184504 1 0.240386 C12 110303084 rs10849944 rs3184504 1 0.240386 C12 110309772 rs7302763 rs3184504 1 0.243781 C12 110311952 rs10849946 rs3184504 1 0.240386 C12 110314868 rs4766573 rs3184504 1 0.240386 C12 110315192 rs10774623 rs3184504 1 0.240386 C12 110317972 rs12580300 rs3184504 1 0.219935 C12 110333654 rs11065898 rs3184504 1 0.25096 C12 110346958 rs10849947 rs3184504 1 0.236063 C12 110349067 rs2283358 rs3184504 1 0.219935 C12 110349948 rs7296313 rs3184504 1 0.230047 C12 110362909 rs2239195 rs3184504 1 0.23445 C12 110365692 rs2238154 rs3184504 1 0.219935 C12 110366868 rs3184504 rs3184504 1 1 C12 110368991 rs739496 rs3184504 1 0.230047 C12 110372042 rs10849949 rs3184504 1 0.219935 C12 110377920 rs2073950 rs3184504 1 0.219935 C12 110378455 rs2301622 rs3184504 1 0.222294 C12 110379586 rs2301621 rs3184504 1 0.219935 C12 110379655 rs4766578 rs3184504 1 0.965238 C12 110388754 rs10774625 rs3184504 1 0.965961 C12 110394602 rs2339816 rs3184504 1 0.218055 C12 110396571 rs1029388 rs3184504 1 0.219935 C12 110411284 rs6490162 rs3184504 1 0.219935 C12 110425503 rs628825 rs3184504 1 0.200363 C12 110436233 rs630512 rs3184504 1 0.200363 C12 110436550 rs688812 rs3184504 1 0.204072 C12 110446964 rs657197 rs3184504 1 0.201774 C12 110450041 rs607316 rs3184504 1 0.200363 C12 110453831 rs616668 rs3184504 1 0.200363 C12 110458663 rs648997 rs3184504 1 0.370996 C12 110461159 rs625093 rs3184504 1 0.200363 C12 110472815 rs638791 rs3184504 1 0.200363 C12 110473619 rs593226 rs3184504 1 0.319821 C12 110478269 rs616559 rs3184504 1 0.204072 C12 110487733 rs616513 rs3184504 1 0.200363 C12 110487766 rs653178 rs3184504 1 1 C12 110492139 rs12369009 rs3184504 1 0.200363 C12 110504182 rs695871 rs3184504 0.914919 0.219128 C12 110521383 rs11065987 rs3184504 0.958507 0.690892 C12 110556807 rs601663 rs3184504 0.793576 0.226059 C12 110607667 rs2238151 rs3184504 0.825316 0.292216 C12 110696216 rs10744777 rs3184504 0.825316 0.292216 C12 110717401

[0131] In a specific embodiment, the marker in LD is a genotyped surrogate marker with r.sup.2>0.2 to the anchor marker. For example, the marker in LD may be a surrogate of Table 1. Thus, for example, surrogate markers for marker rs12619285 may suitably be selected from the group consisting of rs12617902, rs4672665, rs16849446, rs975381, rs2170572, rs7560454, rs12619285, rs10189498, rs6750754, rs6740906, rs1482577, rs13022407, rs10199053, rs17276404, rs7588793, rs12616485, rs12613560, rs4467215, rs2371786, rs10932456, rs4233991, rs7569831, rs7573040, rs12470672, rs13405747, rs7576646, rs7576850, rs7603237, rs7603346, rs7577413, rs6734978, rs4673714, rs12620781, rs16849550, rs1871946, rs10932460, rs13417169, rs12612034, which are the surrogate markers of rs12619285 listed in Table 2. Surrogate markers of other anchor markers (i.e., rs12619285, rs1420101, rs4857855, rs2416257, rs4143832, rs2269426, rs9494145, rs748065, rs3939286, and rs3184504) may be selected in an analogous fashion.

[0132] Determination of Haplotype Frequency

[0133] The frequencies of haplotypes in patient and control groups can be estimated using an expectation-maximization algorithm (Dempster A. et al., J. R. Stat. Soc. B, 39:1-38 (1977)). An implementation of this algorithm that can handle missing genotypes and uncertainty with the phase can be used. Under the null hypothesis, the patients and the controls are assumed to have identical frequencies. Using a likelihood approach, an alternative hypothesis is tested, where a candidate at-risk haplotype, which can include the markers described herein, is allowed to have a higher frequency in patients than controls, while the ratios of the frequencies of other haplotypes are assumed to be the same in both groups. Likelihoods are maximized separately under both hypotheses and a corresponding 1-df likelihood ratio statistic is used to evaluate the statistical significance.

[0134] To look for at-risk and protective markers and haplotypes within a susceptibility region, for example within an LD block, association of all possible combinations of genotyped markers within the region is studied. The combined patient and control groups can be randomly divided into two sets, equal in size to the original group of patients and controls. The marker and haplotype analysis is then repeated and the most significant p-value registered is determined. This randomization scheme can be repeated, for example, over 100 times to construct an empirical distribution of p-values. In a preferred embodiment, a p-value of <0.05 is indicative of an significant marker and/or haplotype association.

[0135] Haplotype Analysis

[0136] One general approach to haplotype analysis involves using likelihood-based inference applied to NEsted MOdels (Gretarsdottir S., et al., Nat. Genet. 35:131-38 (2003)). The method is implemented in the program NEMO, which allows for many polymorphic markers, SNPs and microsatellites. The method and software are specifically designed for case-control studies where the purpose is to identify haplotype groups that confer different risks. It is also a tool for studying LD structures. In NEMO, maximum likelihood estimates, likelihood ratios and p-values are calculated directly, with the aid of the EM algorithm, for the observed data treating it as a missing-data problem.

[0137] Even though likelihood ratio tests based on likelihoods computed directly for the observed data, which have captured the information loss due to uncertainty in phase and missing genotypes, can be relied on to give valid p-values, it would still be of interest to know how much information had been lost due to the information being incomplete. The information measure for haplotype analysis is described in Nicolae and Kong (Technical Report 537, Department of Statistics, University of Statistics, University of Chicago; Biometrics, 60(2):368-75 (2004)) as a natural extension of information measures defined for linkage analysis, and is implemented in NEMO.

[0138] For single marker association to a disease, the Fisher exact test can be used to calculate two-sided p-values for each individual allele. Usually, all p-values are presented unadjusted for multiple comparisons unless specifically indicated. The presented frequencies (for microsatellites, SNPs and haplotypes) are allelic frequencies as opposed to carrier frequencies. To minimize any bias due the relatedness of the patients who were recruited as families to the study, first and second-degree relatives can be eliminated from the patient list. Furthermore, the test can be repeated for association correcting for any remaining relatedness among the patients, by extending a variance adjustment procedure previously described (Risch, N. & Teng, J. (Genome Res., 8:1273-1288 (1998)), for sibships so that it can be applied to general familial relationships, and present both adjusted and unadjusted p-values for comparison. The method of genomic controls (Devlin, B. & Roeder, K. Biometrics 55:997 (1999)) can also be used to adjust for the relatedness of the individuals and possible stratification. The differences are in general very small as expected. To assess the significance of single-marker association corrected for multiple testing we can carry out a randomization test using the same genotype data. Cohorts of patients and controls can be randomized and the association analysis redone multiple times (e.g., up to 500,000 times) and the p-value is the fraction of replications that produced a p-value for some marker allele that is lower than or equal to the p-value we observed using the original patient and control cohorts.

[0139] For both single-marker and haplotype analyses, relative risk (RR) and the population attributable risk (PAR) can be calculated assuming a multiplicative model (haplotype relative risk model) (Terwilliger, J. D. & Ott, J., Hum. Hered. 42:337-46 (1992) and Falk, C. T. & Rubinstein, P, Ann. Hum. Genet. 51 (Pt 3):227-33 (1987)), i.e., that the risks of the two alleles/haplotypes a person carries multiply. For example, if RR is the risk of A relative to a, then the risk of a person homozygote AA will be RR times that of a heterozygote Aa and RR.sup.2 times that of a homozygote aa. The multiplicative model has a nice property that simplifies analysis and computations--haplotypes are independent, i.e., in Hardy-Weinberg equilibrium, within the affected population as well as within the control population. As a consequence, haplotype counts of the affecteds and controls each have multinomial distributions, but with different haplotype frequencies under the alternative hypothesis. Specifically, for two haplotypes, h.sub.i and h.sub.j, risk (h.sub.i)/risk (h.sub.j)=(f.sub.i/p.sub.i)/(f.sub.j/p.sub.j), where f and p denote, respectively, frequencies in the affected population and in the control population. While there is some power loss if the true model is not multiplicative, the loss tends to be mild except for extreme cases. Most importantly, p-values are always valid since they are computed with respect to null hypothesis.

[0140] An association signal detected in one association study may be replicated in a second cohort, ideally from a different population (e.g., different region of same country, or a different country) of the same or different ethnicity. The advantage of replication studies is that the number of tests performed in the replication study, and hence the less stringent the statistical measure that is applied. For example, for a genome-wide search for susceptibility variants for a particular disease or trait using 300,000 SNPs, a correction for the 300,000 tests performed (one for each SNP) can be performed. Since many SNPs on the arrays typically used are correlated (i.e., in LD), they are not independent. Thus, the correction is conservative. Nevertheless, applying this correction factor requires an observed P-value of less than 0.05/300,000=1.7.times.10.sup.-7 for the signal to be considered significant applying this conservative test on results from a single study cohort. Obviously, signals found in a genome-wide association study with P-values less than this conservative threshold are a measure of a true genetic effect, and replication in additional cohorts is not necessarily from a statistical point of view. However, since the correction factor depends on the number of statistical tests performed, if one signal (one SNP) from an initial study is replicated in a second case-control cohort, the appropriate statistical test for significance is that for a single statistical test, i.e., P-value less than 0.05. Replication studies in one or even several additional case-control cohorts have the added advantage of providing assessment of the association signal in additional populations, thus simultaneously confirming the initial finding and providing an assessment of the overall significance of the genetic variant(s) being tested in human populations in general.

[0141] The results from several case-control cohorts can also be combined to provide an overall assessment of the underlying effect. The methodology commonly used to combine results from multiple genetic association studies is the Mantel-Haenszel model (Mantel and Haenszel, J Natl Cancer Inst 22:719-48 (1959)). The model is designed to deal with the situation where association results from different populations, with each possibly having a different population frequency of the genetic variant, are combined. The model combines the results assuming that the effect of the variant on the risk of the disease, a measured by the OR or RR, is the same in all populations, while the frequency of the variant may differ between the poplations. Combining the results from several populations has the added advantage that the overall power to detect a real underlying association signal is increased, due to the increased statistical power provided by the combined cohorts. Furthermore, any deficiencies in individual studies, for example due to unequal matching of cases and controls or population stratification will tend to balance out when results from multiple cohorts are combined, again providing a better estimate of the true underlying genetic effect.

[0142] Susceptibility

[0143] In certain methods described herein, an individual who is at an increased susceptibility (i.e., increased risk) for any specific disease or trait under study (e.g., eosinophilia, asthma, myocardial infarction, hypertension), is an individual in whom at least one specific allele at one or more polymorphic marker or haplotype conferring (or is shown to correlate with) increased susceptibility for the disease or trait is identified (i.e., at-risk marker alleles or haplotypes). In one aspect, the at-risk marker or haplotype is one that confers a significant or substantial increased risk (or susceptibility) of the disease or trait. In one embodiment, susceptibility associated with a marker or haplotype is measured by a relative risk (RR). In another embodiment, susceptibility associated with a marker or haplotype is measured by an odds ratio (OR). In a further embodiment, the susceptibility is measured by a percentage. In one embodiment, an increased risk is measured as a risk (relative risk and/or odds ratio) of at least about 1.00, including but not limited to: at least about 1.05, at least about 1.10, at least about 1.11, at least about 1.12, at least about 1.13, at least about 1.14, at least about 1.15, at least about 1.16, at least about 1.17, at least about 1.18, at least about 1.19, or at least about 1.20 (e.g., at least about 1.3, at least about 1.4, at least about 1.5, at least about 1.6, at least about 1.7, at least about 1.8, at least about 1.9, at least about 2.0, at least about 2.5, at least about 3.0, at least about 4.0, and at least about 5.0). In a particular embodiment, a risk (relative risk and/or odds ratio) of at least 1.1 is deemed substantial. However, other cutoffs are also contemplated, e.g. at least 1.05, 1.15, 1.25, 1.35, and so on, and such cutoffs are also within scope of the invention. In other embodiments, a substantial increase in risk is at least about 5% or 10% or 15% or 20%, including but not limited to about 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 100%, 150%, 200%, 300%, and 500%. In one particular embodiment, a significant increase in risk is at least 10%. Other cutoffs or ranges as deemed suitable by the person skilled in the art to characterize the invention are however also contemplated, and those are also within scope of the invention.

[0144] An at-risk polymorphic marker or haplotype of the invention is one where at least one allele of at least one marker or haplotype is more frequently present in an individual at risk for the disease or trait (affected), or diagnosed with the disease or trait, compared to the frequency of its presence in a comparison group (control), such that the presence of the marker or haplotype is indicative of susceptibility to the disease or trait. The control group may in one embodiment be a population sample, i.e. a random sample from the general population. In another embodiment, the control group is represented by a group of individuals who are disease-free. Such a disease-free control may in one embodiment be characterized by the absence of one or more specific disease-associated symptoms (e.g., symptoms associated with eosinophilia, asthma, myocardial infarction, hypertension). In another embodiment, the disease-free control group is characterized by the absence of one or more disease-specific risk factors. Such risk factors are in one embodiment at least one environmental risk factor. Representative environmental factors are natural products, minerals or other chemicals which are known to affect, or contemplated to affect, the risk of developing the specific disease or trait. Other environmental risk factors are risk factors related to lifestyle, including but not limited to food and drink habits, geographical location of main habitat, and occupational risk factors. In another embodiment, the risk factors are at least one genetic risk factor.

[0145] As an example of a simple test for correlation is a Fisher-exact test on a two by two table. Given a cohort of chromosomes, the two by two table is constructed out of the number of chromosomes that include both of the markers or haplotypes, one of the markers or haplotypes but not the other and neither of the markers or haplotypes.

[0146] In other embodiments of the invention, an individual who is at a decreased susceptibility (i.e., at a decreased risk) for a disease or trait is an individual in whom at least one specific allele at one or more polymorphic marker or haplotype conferring decreased susceptibility for the disease or trait is identified. The marker alleles and/or haplotypes conferring decreased risk are also said to be protective. In one aspect, the protective marker or haplotype is one that confers a substantial decreased risk (or susceptibility) of the disease or trait. In one embodiment, substantial decreased risk is measured as a relative risk of less than 0.9, including but not limited to less than 0.9, less than 0.8, less than 0.7, less than 0.6, less than 0.5, less than 0.4, less than 0.3, less than 0.2 and less than 0.1. In one particular embodiment, substantial decreased risk is less than 0.7. In another embodiment, substantial decreased risk is less than 0.5. In yet another embodiment, substantial decreased risk is less than 0.3. In another embodiment, the decrease in risk (or susceptibility) is at least 20%, including but not limited to at least 25%, at least 30%, at least 35%, at least 40%, at least 45%, at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 95% and at least 98%. In one particular embodiment, a substantial decrease in risk is at least about 30%. In another embodiment, a significant decrease in risk at least about 50%. In another embodiment, the decrease in risk is at least about 70%. Other cutoffs or ranges as deemed suitable by the person skilled in the art to characterize the invention are however also contemplated, and those are also within scope of the invention.

[0147] The person skilled in the art will appreciate that for markers with exactly two alleles present in the population being studied, and wherein one allele is found in increased frequency in a group of individuals with a trait or disease in the population, compared with controls, the other allele of the marker will be found in decreased frequency in the group of individuals with the trait or disease, compared with controls. In such a case, one allele of the marker (the one found in increased frequency in individuals with the trait or disease) will be the at-risk allele, while the other allele will be a protective allele.

[0148] A genetic variant associated with a disease or a trait (e.g. eosinophilia, asthma, myocardial infarction, hypertension) can be used alone to predict the risk of the disease for a given genotype. For a biallelic marker, such as a SNP, there are 3 possible genotypes: homozygote for the at risk variant, heterozygote, and non-carrier of the at risk variant. Risk associated with variants at multiple loci can be used to estimate overall risk. For multiple SNP variants, there are k possible genotypes k=3n.times.2p; where n is the number autosomal loci and p the number of gonosomal (sex chromosomal) loci. Overall risk assessment calculations usually assume that the relative risks of different genetic variants multiply, i.e. the overall risk (e.g., RR or OR) associated with a particular genotype combination is the product of the risk values for the genotype at each locus. If the risk presented is the relative risk for a person, or a specific genotype for a person, compared to a reference population with matched gender and ethnicity, then the combined risk--is the product of the locus specific risk values--and which also corresponds to an overall risk estimate compared with the population. If the risk for a person is based on a comparison to non-carriers of the at risk allele, then the combined risk corresponds to an estimate that compares the person with a given combination of genotypes at all loci to a group of individuals who do not carry risk variants at any of those loci. The group of non-carriers of any at risk variant has the lowest estimated risk and has a combined risk, compared with itself (i.e., non-carriers) of 1.0, but has an overall risk, compare with the population, of less than 1.0. It should be noted that the group of non-carriers can potentially be very small, especially for large number of loci, and in that case, its relevance is correspondingly small.

[0149] The multiplicative model is a parsimonious model that usually fits the data of complex traits reasonably well. Deviations from multiplicity have been rarely described in the context of common variants for common diseases, and if reported are usually only suggestive since very large sample sizes are usually required to be able to demonstrate statistical interactions between loci.

[0150] By way of an example, let us consider a total of eight variants that have been described to associate with prostate cancer (Gudmundsson et al., Nat Genet 39:631-7 (2007), Gudmundsson et al., Nat Genet 39:977-83 (2007); Yeager et al, Nat Genet 39:645-49 (2007), Amundadottir et al., Nat Genet 38:652-8 (2006); Haiman et al., Nat Genet 39:638-44 (2007)). Seven of these loci are on autosomes, and the remaining locus is on chromosome X. The total number of theoretical genotypic combinations is then 3.sup.7.times.2.sup.1=4374. Some of those genotypic classes are very rare, but are still possible, and should be considered for overall risk assessment. It is likely that the multiplicative model applied in the case of multiple genetic variant will also be valid in conjugation with non-genetic risk variants assuming that the genetic variant does not clearly correlate with the "environmental" factor. In other words, genetic and non-genetic at-risk variants can be assessed under the multiplicative model to estimate combined risk, assuming that the non-genetic and genetic risk factors do not interact.

[0151] Using the same quantitative approach, the combined or overall risk associated with a plurality of variants associated with eosinophilia, asthma, myocardial infarction, and/or hypertension may be assessed.

[0152] Database

[0153] Determining susceptibility can alternatively or additionally comprise comparing the nucleic acid sequence data to a database containing correlation data between polymorphic markers of at least one of the genes and susceptibility to eosinophilia, a condition causative of eosinophilia (e.g., asthma, myocardial infaction), or hypertension. The database can be part of a computer-readable medium described herein.

[0154] In a specific aspect of the invention, the database comprises at least one measure of susceptibility to eosinophilia, a condition causative of eosinophilia (e.g., asthma, myocardial infaction), or hypertension, for the polymorphic markers.

[0155] In another specific aspect of the invention, the database comprises a look-up table containing at least one measure of susceptibility to eosinophilia, a condition causative of eosinophilia (e.g., asthma, myocardial infaction), or hypertension for the polymorphic markers.

[0156] Further Steps

[0157] The methods disclosed herein can comprise additional steps which may occur before, after, or simultaneously with one of the aforementioned steps of the method of the invention. In a specific embodiment of the invention, the method of determining a susceptibility to eosinophilia, a condition causative of eosinophilia (e.g., asthma, myocardial infarction), or hypertension, further comprises reporting the susceptibility to at least one entity selected from the group consisting of the individual, a guardian of the individual, a genetic service provider, a physician, a medical organization, and a medical insurer. The reporting may be accomplished by any of several means. For example, the reporting can comprise sending a written report on physical media or electronically or providing an oral report to at least one entity of the group, which written or oral report comprises the susceptibility. Alternatively, the reporting can comprise providing the at least one entity of the group with a login and password, which provides access to a report comprising the susceptibility posted on a password-protected website.

[0158] Study Population

[0159] In a general sense, the methods and kits of the invention can be utilized from samples containing genomic DNA from any source, i.e. any individual. In specific embodiments, the individual is a human individual. The individual can be an adult, child, or fetus. The invention also provides for assessing markers and/or haplotypes in individuals who are members of a target population. Such a target population is in one embodiment a population or group of individuals at risk of developing eosinophilia, a condition causative of eosinophilia (e.g., asthma, myocardial infarction), or hypertension, based on other genetic factors, biomarkers, biophysical parameters, history of eosinophilia, asthma, myocardial infarction, hypertension, or related diseases, previous diagnosis of eosinophilia, asthma, myocardial infarction, hypertension, family history of eosinophilia, asthma, myocardial infarction, hypertension or general health and/or lifestyle parameters.

[0160] The invention provides for embodiments that include individuals from specific age subgroups, of a specific gender, or of a specific ethnic background.

[0161] The Icelandic population is a Caucasian population of Northern European ancestry. A large number of studies reporting results of genetic linkage and association in the Icelandic population have been published in the last few years. Many of those studies show replication of variants, originally identified in the Icelandic population as being associating with a particular disease, in other populations (Styrkarsdottir et al., N Engl J Med 358:2355-65 (2008); Thorgeirsson et al., Nature 452:638-42 (2008); Gudmundsson et al., Nat Genet. 40:281-3 (2008); Stacey et al., Nat Genet. 39:865-69 (2007); Helgadottir et al., Science 316:1491-93 (2007); Steinthorsdottir et al., Nat Genet. 39:770-75 (2007); Gudmundsson et al., Nat Genet. 39:631-37 (2007); Frayling, Nature Reviews Genet 8:657-662 (2007); Amundadottir et al., Nat Genet. 38:652-58 (2006); Grant et al., Nat Genet. 38:320-23 (2006)). Thus, genetic findings in the Icelandic population have in general been replicated in other populations, including populations from Africa and Asia. Moreover, the association of the variants described herein to be associated with increased risk of eosinophilia, asthma, myocardial infarction and/or hypertension has been replicated in several populations, including Caucasians from Europe and North America (e.g., Icelandic, Itailian, German, British, Danish, and Dutch), Caucasian Australians, New Zealanders, Hong Kong Chinese, and in Koreans.

[0162] The markers of the present invention found to be associated with eosinophilia, asthma, myocardial infarction, and/or hypertension are therefore believed to show similar association in all human populations. Particular embodiments comprising individual human populations are thus also contemplated and within the scope of the invention. Such embodiments relate to human individuals that are from one or more human population including, but not limited to, Caucasian populations, European populations, American populations, Eurasian populations, Asian populations, Central/South Asian populations, East Asian populations, Middle Eastern populations, African populations, Hispanic populations, and Oceanian populations. European populations include, but are not limited to, Swedish, Norwegian, Finnish, Russian, Danish, Icelandic, Irish, Kelt, English, Scottish, Dutch, Belgian, French, German, Spanish, Portuguese, Italian, Polish, Bulgarian, Slavic, Serbian, Bosnian, Chech, Greek and Turkish populations. The invention furthermore in other embodiments can be practiced in specific human populations that include Bantu, Mandenk, Yoruba, San, Mbuti Pygmy, Orcadian, Adygel, Russian, Sardinian, Tuscan, Mozabite, Bedouin, Druze, Palestinian, Balochi, Brahui, Makrani, Sindhi, Pathan, Burusho, Hazara, Uygur, Kalash, Han, Dai, Daur, Hezhen, Lahu, Miao, Orogen, She, Tujia, Tu, Xibo, Yi, Mongolan, Naxi, Cambodian, Japanese, Yakut, Melanesian, Papuan, Karitianan, Surui, Colombian, Maya, Pima, Korean, Hong Kong Chinese, New Zealander, and Caucasian Austrailian.

[0163] In certain embodiments, the invention relates to populations that include black African ancestry such as populations comprising persons of African descent or lineage. Black African ancestry may be determined by self reporting as African-Americans, Afro-Americans, Black Americans, being a member of the black race or being a member of the negro race. For example, African Americans or Black Americans are those persons living in North America and having origins in any of the black racial groups of Africa. In another example, self-reported persons of black African ancestry may have at least one parent of black African ancestry or at least one grandparent of black African ancestry.

[0164] The racial contribution in individual subjects may also be determined by genetic analysis. Genetic analysis of ancestry may be carried out using unlinked microsatellite markers such as those set out in Smith et al. (Am J Hum Genet 74, 1001-13 (2004)).

[0165] In certain embodiments, the invention relates to markers and/or haplotypes identified in specific populations, as described in the above. The person skilled in the art will appreciate that measures of linkage disequilibrium (LD) may give different results when applied to different populations. This is due to different population history of different human populations as well as differential selective pressures that may have led to differences in LD in specific genomic regions. It is also well known to the person skilled in the art that certain markers, e.g. SNP markers, have different population frequency in different populations, or are polymorphic in one population but not in another. The person skilled in the art will however apply the methods available and as taught herein to practice the invention in any given human population. This may include assessment of polymorphic markers in the LD region of the present invention, so as to identify those markers that give strongest association within the specific population. Thus, the at-risk variants of the invention may reside on different haplotype background and in different frequencies in various human populations. However, utilizing methods taught herein and the markers of the invention, the invention can be practiced in any given human population.

[0166] Screening Methods

[0167] The invention also provides a method of screening a candidate marker for assessing susceptibility to a condition causative of or correlative/associated with eosinophilia. The method comprises analyzing the frequency of at least one allele of a polymorphic marker in a population of human individuals diagnosed with the condition, wherein a significant difference in frequency of the at least one allele in the population of human individuals diagnosed with the condition as compared to the frequency of the at least one allele in a control population of human individuals is indicative of the allele as a marker of the condition.

[0168] In a specific embodiment of the invention, the at least one allele of a polymorphic marker is selected from the group consisting of: the C allele of rs1050152, the A allele of rs11066320, the G allele of rs11679137, the C allele of rs11778166, the A allele of rs11950562, the G allele of rs12411706, the G allele of rs9954643, the A allele of rs12619285, the T allele of rs1265566, the T allele of rs12998521, the A allele of rs1370631, the T allele of rs1412426, the A allele of rs1420101, the A allele of rs1467412, the A allele of rs1559930, the G allele of rs1805419, the G allele of rs184941, the T allele of rs2079103, the C allele of rs2164850, the A allele of rs2165427, the C allele of rs2188962, the C allele of rs2244012, the T allele of rs2269426, the C allele of rs231228, the C allele of rs2335050, the G allele of rs233716, the C allele of rs233722, the G allele of rs2416257, the C allele of rs2426358, the C allele of rs2532072, the T allele of rs2663041, the A allele of rs272893, the G allele of rs273148, the A allele of rs2897443, the T allele of rs3184504, the A allele of rs3939286, the A allele of rs4143832, the G allele of rs4629469, the G allele of rs4773225, the A allele of rs4851400, the T allele of rs4851411, the C allele of rs4857855, the T allele of rs6439132, the A allele of rs6503609, the G allele of rs653178, the T allele of rs6730424, the C allele of rs6871536, the G allele of rs7150454, the G allele of rs7223150, the A allele of rs7315519, the A allele of rs748065, the A allele of rs7635061, the C allele of rs927220, the T allele of rs9494145, and the A allele of rs992969.

[0169] In another specific aspect, the at least one allele is selected from the group consisting of: the A allele of rs1420101, the A allele of rs12619285, the C allele of rs4857855, the A allele of rs7635061, the G allele of rs2416257, the G allele of rs184941, the A allele of rs4143832, the T allele of rs2079103, the T allele of rs2269426, the T allele of rs9494145, the A allele of rs748065, the T allele of rs1412426, the A allele of rs3939286, the T allele of rs3184504, and the G allele of rs653178.

[0170] In yet another specific aspect of the invention, the at least one allele is selected from the group consisting of: the A allele of rs1420101, the A allele of rs12619285, the C allele of rs4857855, the G allele of rs2416257, the A allele of rs4143832, the T allele of rs2269426, the T allele of rs9494145, the A allele of rs748065, the A allele of rs3939286, and the T allele of rs3184504.

[0171] With regard to the screening method of the invention, the condition causative of or correlated/associated with eosinophilia can be any of those described herein. For example, the condition can be one of eczema, atopic dermatitis, rhinitis, a parasitic infection, a drug reaction, Loeffler's syndrome, vasculitis, Churg-Strauss syndrome, tumors, cirrhosis, an antibody deficiency, dermatitis, herpetiformis, leukemia, an inflammatory disease, allergic rhinoconjuntivitis, eosinophil esophagitis, eosinophili fascitis, and an autoimmune disease.

[0172] Suitable methods of analyzing the frequency of alleles in a human population are known in the art and include, for example, calculating the allele frequency from genotype frequency and consulting the allele frequency database (ALFRED) (see, for example, Cheung et al., Nuci Acids Res 28: 361-363 (2000)).

[0173] Genotyping Methods

[0174] The invention further provides methods of genotyping a sample, e.g., a nucleic acid sample, obtained from a human individual. In one embodiment, the human individual is at risk for, or diagnosed with, eosinophilia. The method comprises determining the identity of at least one allele of at least one polymorphic marker in the sample, wherein the marker is selected from the group consisting of: rs1050152, rs11066320, rs11679137, rs11778166, rs11950562, rs12411706, rs9954643, rs12619285, rs1265566, rs12998521, rs1370631, rs1412426, rs1420101, rs1467412, rs1559930, rs1805419, rs184941, rs2079103, rs2164850, rs2165427, rs2188962, rs2244012, rs2269426, rs231228, rs2335050, rs233716, rs233722, rs2416257, rs2426358, rs2532072, rs2663041, rs272893, rs273148, rs2897443, rs3184504, rs3939286, rs4143832, rs4629469, rs4773225, rs4851400, rs4851411, rs4857855, rs6439132, rs6503609, rs653178, rs6730424, rs6871536, rs7150454, rs7223150, rs7315519, rs748065, rs7635061, rs927220, rs9494145, and rs992969, and markers in linkage disequilibrium therewith. In this embodiment of the inventive genotyping methods, the identity of the at least one allele of the at least one polymorphic marker is indicative of a susceptibility to eosinophilia.

[0175] In another embodiment, the human individual is at risk for, or diagnosed with, asthma, and the method comprises determining the identity of at least one allele of at least one polymorphic marker in the sample, wherein the marker is selected from the group consisting of: rs1420101, rs3939286, rs2416257, and rs9494145, and markers in linkage disequilibrium therewith. In this embodiment of the inventive genotyping methods, the identity of the at least one allele of the at least one polymorphic marker is indicative of a susceptibility (or contribution factor for) to asthma.

[0176] In yet another embodiment of the invention, the human individual is at risk for, or diagnosed with, myocardial infarction, and the method comprises determining the identity of at least one allele of at least one polymorphic marker in the sample, wherein the marker is selected from the group consisting of: rs3184504 and rs653178, and markers in linkage disequilibrium therewith. In this embodiment of the inventive genotyping methods, the identity of the at least one allele of the at least one polymorphic marker is indicative of a susceptibility (or contribution factor for) to myocardial infarction.

[0177] In yet another embodiment of the invention, the human individual is at risk for, or diagnosed with, hypertension, and the method comprises determining the identity of at least one allele of at least one polymorphic marker in the sample, wherein the marker is selected from the group consisting of: rs3184504, and markers in linkage disequilibrium therewith. In this embodiment of the inventive genotyping methods, the identity of the at least one allele of the at least one polymorphic marker is indicative of a susceptibility (or contribution factor for) to hypertension.

[0178] Suitable methods of genotyping are known in the art and include, for example, any of the genotyping methods described herein.

[0179] Utility of Genetic Testing

[0180] The variants described herein in general do not, by themselves, provide an absolute identification of individuals who will develop a particular disease. The variants described herein do however indicate increased and/or decreased likelihood that individuals carrying the at-risk or protective variants of the invention will develop symptoms associated with eosinophilia, asthma, myocardial infarction, and/or hypertension. This information is however extremely valuable in itself, as outlined in more detail in the below, as it can be used to, for example, initiate preventive measures at an early stage, perform regular physical and/or mental exams to monitor the progress and/or appearance of symptoms, or to schedule exams at a regular interval to identify the condition in question, so as to be able to apply treatment at an early stage.

[0181] The knowledge about a genetic variant that confers a risk of developing eosinophilia, asthma, myocardial infarction, and/or hypertension offers the opportunity to apply a genetic test to distinguish between individuals with increased risk (attributable to the genetic variant) of developing eosinophilia, asthma, myocardial infarction, and/or hypertension (i.e. carriers of the at-risk variant) and those with decreased risk of developing eosinophilia, asthma, myocardial infarction, and/or hypertension (i.e. carriers of the protective variant). The core values of genetic testing, for individuals belonging to both of the above mentioned groups, are the possibilities of being able to diagnose eosinophilia, asthma, myocardial infarction, and/or hypertension, or a predisposition to eosinophilia, asthma, myocardial infarction, and/or hypertension, at an early stage and provide information to the clinician about prognosis/aggressiveness of eosinophilia, asthma, myocardial infarction, and/or hypertension, in order to be able to apply the most appropriate treatment.

[0182] Individuals with a family history of eosinophilia, asthma, myocardial infarction, and/or hypertension, and carriers of at-risk variants may benefit from genetic testing since the knowledge of the presence of a genetic risk factor, or evidence for increased risk of being a carrier of one or more risk factors, may provide increased incentive for implementing a healthier lifestyle, by avoiding or minimizing known environmental risk factors for eosinophilia, asthma, myocardial infarction, and/or hypertension. Genetic testing of eosinophilia, asthma, myocardial infarction, and/or hypertension patients may furthermore give valuable information about the primary cause of eosinophilia, asthma, myocardial infarction, and/or hypertension and can aid the clinician in selecting the best treatment options and medication for each individual. Further, individuals who are carriers of the at-risk variants of the invention are likely to benefit from regular monitoring from the clinician, so as to minimize the risk of developing symptoms with, or being diagnosed with, eosinophilia, asthma, myocardial infarction, and/or hypertension.

[0183] The invention furthermore relates to risk assessment for eosinophilia, asthma, myocardial infarction, and/or hypertension, including diagnosing whether an individual is at risk for developing eosinophilia, asthma, myocardial infarction, and/or hypertension. The polymorphic markers of the invention can be used alone or in combination, as well as in combination with other factors, including other genetic risk factors or biomarkers, for risk assessment of an individual for eosinophilia, asthma, myocardial infarction, and/or hypertension.

[0184] Yet another utility lies on the use of genetic markers to determine whether to apply particular treatment modalities. Thus, based on the carrier status of particular markers and haplotypes described herein to be associated with risk of eosinophilia, asthma, myocardial infarction, and/or hypertension, a particular treatment is administered. This can for example be done by first determining whether an individual is carrying at least one particular risk allele of one or more markers, or by determining the carrier status of the individual with respect to at least one particular haplotype. Based on the result of the genetic analysis, the particular treatment modality is administered.

[0185] Methods known in the art can be used for such assessment, including multivariate analyses or logistic regression.

[0186] Prognostic Methods

[0187] In addition to the utilities described above, the polymorphic markers of the invention are useful in determining a prognosis of a human individual experiencing symptoms associated with, or an individual diagnosed with eosinophilia, asthma, myocardial infarction, and/or hypertension. Accordingly, the invention provides a method of predicting prognosis of an individual experiencing symptoms associated with, or an individual diagnosed with, eosinophilia. The method comprises obtaining sequence data about a human individual identifying at least one allele of at least one polymorphic marker associated with a gene selected from the group consisting of ATP9A, ATXN2, BAX, CUX2, IL1RL1, IL33, LBH, LOC441108, PTPN11, RAD50, RAD51L1, SH2B3, SLC22A4, SNX6, TBC1D8, TNKS2, and TNXB, wherein different alleles of the at least one polymorphic marker are associated with different susceptibilities to eosinophilia in humans, and predicting prognosis of the individual from the sequence data. In one embodiment, the at least one polymorphic marker selected from the group consisting of: rs1050152, rs11066320, rs11679137, rs11778166, rs11950562, rs12411706, rs9954643, rs12619285, rs1265566, rs12998521, rs1370631, rs1412426, rs1420101, rs1467412, rs1559930, rs1805419, rs184941, rs2079103, rs2164850, rs2165427, rs2188962, rs2244012, rs2269426, rs231228, rs2335050, rs233716, rs233722, rs2416257, rs2426358, rs2532072, rs2663041, rs272893, rs273148, rs2897443, rs3184504, rs3939286, rs4143832, rs4629469, rs4773225, rs4851400, rs4851411, rs4857855, rs6439132, rs6503609, rs653178, rs6730424, rs6871536, rs7150454, rs7223150, rs7315519, rs748065, rs7635061, rs927220, rs9494145, and rs992969, and markers in linkage disequilibrium therewith.

[0188] The invention also provides a method of predicting prognosis of an individual experiencing symptoms associated with, or an individual diagnosed with, asthma. The method comprises obtaining sequence data about a human individual identifying at least one allele of at least one polymorphic marker associated with a gene selected from the group consisting of IL1RL1, IL33, and WDR36, wherein different alleles of the at least one polymorphic marker are associated with different susceptibilities to asthma in humans, and predicting prognosis of the individual from the sequence data. In one embodiment, the at least one polymorphic marker is selected from the group consisting of rs1420101, rs3939286, rs2416257, and rs9494145, and markers in linkage disquilibrium therewith.

[0189] The invention further provides a method of predicting prognosis of an individual experiencing symptoms associated with, or an individual diagnosed with, myocardial infarction. The method comprises obtaining sequence data about a human individual identifying at least one allele of at least one polymorphic marker associated with a gene selected from the group consisting of SH2B3 and ATXN2, wherein different alleles of the at least one polymorphic marker are associated with different susceptibilities to myocardial infarction in humans, and predicting prognosis of the individual from the sequence data. In one embodiment, the at least one marker is selected from the group consisting of: rs3184504 and rs653178, and markers in linkage disquilibrium therewith.

[0190] The invention further provides a method of predicting prognosis of an individual experiencing symptoms associated with, or an individual diagnosed with, hypertension. The method comprises obtaining sequence data about a human individual identifying at least one allele of at least one polymorphic marker associated with a gene selected from the group consisting of SH2B3, wherein different alleles of the at least one polymorphic marker are associated with different susceptibilities to hypertension in humans, and predicting prognosis of the individual from the sequence data. In one embodiment, the at least one marker is selected from the group consisting of: rs3184504, and markers in linkage disquilibrium therewith.

[0191] The prognosis predicted by the methods of the invention can be any type of prognosis relating to the progression of the eosinophilia, asthma, myocardial infarction, and/or hypertension, and/or relating to the chance of recovering from the condition. The prognosis can, for instance, relate to the severity of the eosinophilia, asthma, myocardial infarction, and/or hypertension, when a myocardial infarction or asthma attack might take place, or how the condition will respond to therapeutic treatment.

[0192] With regard to the prognostic methods described herein, the sequence data can be nucleic acid sequence data or amino acid sequence data. Suitable methods of obtaining each are known in the art, some of which are described herein.

[0193] Methods for Predicting Response to Therapeutic Agents

[0194] As is known in the art, individuals can have differential responses to a particular therapy (e.g., a therapeutic agent or therapeutic method). Pharmacogenomics addresses the issue of how genetic variations (e.g., the variants (markers and/or haplotypes) of the invention) affect drug response, due to altered drug disposition and/or abnormal or altered action of the drug. Thus, the basis of the differential response may be genetically determined in part. Clinical outcomes due to genetic variations affecting drug response may result in toxicity of the drug in certain individuals (e.g., carriers or non-carriers of the genetic variants of the invention), or therapeutic failure of the drug. Therefore, the variants of the invention may determine the manner in which a therapeutic agent and/or method acts on the body, or the way in which the body metabolizes the therapeutic agent.

[0195] Accordingly, in one embodiment, the presence of a particular allele at a polymorphic site or haplotype is indicative of a different response, e.g. a different response rate, to a particular treatment modality. This means that a patient diagnosed with eosinophilia, asthma, myocardial infarction, and/or hypertension and carrying a certain allele at a polymorphic site or haplotype of the invention (e.g., the at-risk markers of the invention) would respond better to, or worse to, a specific therapeutic, drug and/or other therapy used to treat the disease. Therefore, the presence or absence of the marker allele or haplotype could aid in deciding what treatment should be used for the patient. For example, for a newly diagnosed patient, the presence of a marker or haplotype of the invention may be assessed (e.g., through testing DNA derived from a blood sample, as described herein). If the patient is positive for a marker allele or haplotype at (that is, at least one specific allele of the marker, or haplotype, is present), then the physician recommends one particular therapy, while if the patient is negative for the at least one allele of a marker, or a haplotype, then a different course of therapy may be recommended (which may include recommending that no immediate therapy, other than serial monitoring for progression of the disease, be performed). Thus, the patient's carrier status could be used to help determine whether a particular treatment modality should be administered. The value lies within the possibilities of being able to diagnose the disease at an early stage, to select the most appropriate treatment, and provide information to the clinician about prognosis/aggressiveness of the disease in order to be able to apply the most appropriate treatment.

[0196] Another aspect of the invention relates to methods of selecting individuals suitable for a particular treatment modality, based on the their likelihood of developing particular complications or side effects of the particular treatment. It is well known that most therapeutic agents can lead to certain unwanted complications or side effects. Likewise, certain therapeutic procedures or operations may have complications associated with them. Complications or side effects of these particular treatments or associated with specific therapeutic agents can, just as diseases do, have a genetic component. It is therefore contemplated that selection of the appropriate treatment or therapeutic agent can in part be performed by determining the genotype of an individual, and using the genotype status of the individual to decide on a suitable therapeutic procedure or on a suitable therapeutic agent to treat the particular disease. It is therefore contemplated that the polymorphic markers of the invention can be used in this manner. In particular, the polymorphic markers of the invention can be used to determine whether administration of a particular therapeutic agent or treatment modality or method is suitable for the individual, based on estimating the likelihood that the individual will develop symptoms associated with eosinophilia, asthma, myocardial infarction, and/or hypertension as a consequence of being administered the particular therapeutic agent or treatment modality or method. Indiscriminate use of a such therapeutic agents or treatment modalities may lead to unnecessary and needless adverse complications.

[0197] In view of the foregoing, the invention provides a method of assessing an individual for probability of response to a therapeutic agent for preventing, treating, and/or ameliorating symptoms associated with eosinophilia. In one embodiment, the method comprises: determining the identity of at least one allele of at least one polymorphic marker in a sample, e.g., a nucleic acid sample, obtained from the individual, wherein the at least one polymorphic marker is selected from polymorphic markers associated with a gene selected from the group consisting of ATP9A, ATXN2, BAX, CUX2, IL1RL1, IL33, LBH, LOC441108, PTPN11, RAD50, RAD51L1, SH2B3, SLC22A4, SNX6, TBC1D8, TNKS2, TNXB, BRAP, ACAD10, ALDH2, MAPKAPK5, and ERP29, wherein the identity of the at least one allele of the at least one marker is indicative of a probability of a positive response to the therapeutic agent.

[0198] In another embodiment, the method comprises: determining the identity of at least one allele of at least one polymorphic marker in a sample, e.g., a nucleic acid sample, obtained from the individual, wherein the at least one polymorphic marker is selected from the group consisting of: rs1370631, rs4851400, rs4851411, rs12998521, rs1559930, rs6439132, rs2335050, rs11950562, rs272893, rs1050152, rs2188962, rs2244012, rs2897443, rs6871536, rs992969, rs1265566, rs7315519, rs927220, rs1467412, rs12411706, rs233722, rs233716, rs1805419, rs9954643, rs273148, rs3939286, rs1420101, rs11066320, rs4857855, rs9494145, rs2416257, rs2079103, rs2165427, rs3184504, rs2663041, rs1412426, rs11778166, rs4143832, rs653178, rs6730424, rs4629469, rs748065, rs11679137, rs2164850, rs12619285, rs2269426, rs7635061, rs184941, rs2532072, rs6503609, rs4773225, rs2426358, rs231228, rs7223150, and rs7150454, and markers in linkage disequilibrium therewith, wherein the identity of the at least one allele of the at least one marker is indicative of a probability of a positive response to the therapeutic agent.

[0199] The invention also provides a method of assessing an individual for probability of response to a therapeutic agent for preventing, treating, and/or ameliorating symptoms associated with asthma. In one embodiment, the method comprises: determining the identity of at least one allele of at least one polymorphic marker in a nucleic acid sample obtained from the individual, wherein the at least one polymorphic marker is selected from polymorphic markers associated with a gene selected from the group consisting of IL1RL1, IL33, and WDR36, wherein the identity of the at least one allele of the at least one marker is indicative of a probability of a positive response to the therapeutic agent.

[0200] In another embodiment, the method comprises: determining the identity of at least one allele of at least one polymorphic marker in a nucleic acid sample obtained from the individual, wherein the at least one polymorphic marker is selected from the group consisting of rs1420101, rs3939286, rs2416257, rs9494145, rs1420101, and markers in linkage disequilibrium therewith, wherein the identity of the at least one allele of the at least one marker is indicative of a probability of a positive response to the therapeutic agent.

[0201] The invention further provides a method of assessing an individual for probability of response to a therapeutic agent for preventing, treating, and/or ameliorating symptoms associated with myocardial infarction. In one embodiment, the method comprises: determining the identity of at least one allele of at least one polymorphic marker in a nucleic acid sample obtained from the individual, wherein the at least one polymorphic marker is selected from polymorphic markers associated with a gene selected from the group consisting of SH2B3 and ATXN2, wherein the identity of the at least one allele of the at least one marker is indicative of a probability of a positive response to the therapeutic agent.

[0202] In another embodiment, the method comprises: determining the identity of at least one allele of at least one polymorphic marker in a nucleic acid sample obtained from the individual, wherein the at least one polymorphic marker is selected from the group consisting of: rs3184504, rs653178, and markers in linkage disequilibrium therewith, wherein the identity of the at least one allele of the at least one marker is indicative of a probability of a positive response to the therapeutic agent.

[0203] The invention further provides a method of assessing an individual for probability of response to a therapeutic agent for preventing, treating, and/or ameliorating symptoms associated with hypertension. In one embodiment, the method comprises: determining the identity of at least one allele of at least one polymorphic marker in a nucleic acid sample obtained from the individual, wherein the at least one polymorphic marker is selected from polymorphic markers associated with a gene selected from the group consisting of SH2B3, wherein the identity of the at least one allele of the at least one marker is indicative of a probability of a positive response to the therapeutic agent.

[0204] In another embodiment, the method comprises: determining the identity of at least one allele of at least one polymorphic marker in a nucleic acid sample obtained from the individual, wherein the at least one polymorphic marker is selected from the group consisting of: rs3184504, and markers in linkage disequilibrium therewith, wherein the identity of the at least one allele of the at least one marker is indicative of a probability of a positive response to the therapeutic agent.

[0205] In a further aspect, the markers of the invention can be used to increase power and effectiveness of clinical trials. Thus, individuals who are carriers of at least one at-risk variant of the present invention, i.e. individuals who are carriers of at least one allele of at least one polymorphic marker conferring increased risk of developing eosinophilia, asthma, myocardial infarction, and/or hypertension may be more likely to respond to a particular treatment modality. In one embodiment, individuals who carry at-risk variants for gene(s) in a pathway and/or metabolic network for which a particular treatment (e.g., small molecule drug) is targeting, are more likely to be responders to the treatment. For some treatments, the genetic risk will correlate with less responsiveness to therapy. In another embodiment, individuals who carry at-risk variants for a gene, which expression and/or function is altered by the at-risk variant, are more likely to be responders (or non-responders) to a treatment modality targeting that gene, its expression or its gene product. This application can improve the safety of clinical trials, but can also enhance the chance that a clinical trial will demonstrate statistically significant efficacy, which may be limited to a certain sub-group of the population. Thus, one possible outcome of such a trial is that carriers of certain genetic variants, e.g., the markers and haplotypes of the invention, are statistically significantly likely to show positive response to the therapeutic agent, i.e. experience alleviation of symptoms associated with eosinophilia, asthma, myocardial infarction and/or hypertension when taking the therapeutic agent or drug as prescribed. Another possible outcome is that genetic carriers show less favorable response to the therapeutic agent, or show differential side-effects to the therapeutic agent compared to the non-carrier. An aspect of the invention is directed to screening for such pharmacogenetic correlations.

[0206] Diagnostic Methods

[0207] The polymorphic markers associated with increased susceptibility to eosinophilia, asthma, myocardial infarction, or hypertension are useful in diagnostic methods. While methods of diagnosing such conditions are known in the art, the detection of one or more alleles of the specific polymorphic markers advantageously reduces the occurrence of mis-diagnosis. In this regard, the invention further provides methods of diagnosing eosinophilia, asthma, myocardial infarction, or hypertension comprising obtaining sequence data, e.g., nucleic acid sequence data, identifying at least one allele of at least one polymorphic marker of a specified group, in conjunction with carrying out one or more steps, e.g., clinical diagnostic steps, such as any of those described herein.

[0208] With regard to the method of diagnosing eosinophilia, the group of polymorphic markers consists of rs1370631, rs4851400, rs4851411, rs12998521, rs1559930, rs6439132, rs2335050, rs11950562, rs272893, rs1050152, rs2188962, rs2244012, rs2897443, rs6871536, rs992969, rs1265566, rs7315519, rs927220, rs1467412, rs12411706, rs233722, rs233716, rs1805419, rs9954643, rs273148, rs3939286, rs1420101, rs11066320, rs4857855, rs9494145, rs2416257, rs2079103, rs2165427, rs3184504, rs2663041, rs1412426, rs11778166, rs4143832, rs653178, rs6730424, rs4629469, rs748065, rs11679137, rs2164850, rs12619285, rs2269426, rs7635061, rs184941, rs2532072, rs6503609, rs4773225, rs2426358, rs231228, rs7223150, and rs7150454, and markers in linkage disequilibrium therewith. In one embodiment, the identification of at least one allele of at least one of these polymorphic markers is carried out in conjunction with measuring the count of eosinophils in the blood of the human individual being diagnosed.

[0209] With regard to the method of diagnosing asthma, the group of polymorphic markers consists of rs1420101, rs3939286, rs2416257, rs9494145, rs1420101, and markers in linkage disequilibrium therewith. In one embodiment, the identification of at least one allele of at least one of these polymorphic markers is carried out in conjunction with one or a combination of (i) considering symptoms experienced by the human individual and/or the family history of the human individual, (ii) physically examining the upper respiratory tract, chest, and skin of the human individual, and (iii) conducting a breathing test on the human individual.

[0210] With regard to the method of diagnosing myocardial infarction, the group of polymorphic markers consists of rs3184504 and rs653178, and markers in linkage disequilibrium therewith. In a specific embodiment, the identification of at least one allele of at least one of these polymorphic markers is carried out in combination with one or a combination of (i) considering the history of an illness and the symptoms experienced by the human individual, (ii) physically examining the human individual, (iii) conducting one or a combination of an electrocardiogram, a coronary angiogram, chest radiograph, and echocardiogram on the human individual, (iv) testing blood of the human individual for cardiac markers, (v) detecting areas of reduced blood flow in conjunction with physiologic or pharmacologic stress, and (vi) determining the viability of tissue of the myocardium.

[0211] With regard to the method of diagnosing hypertension, the group of polymorphic markers consists of rs3184504, and markers in linkage disequilibrium therewith. In a specific embodiment, the identification of at least one allele of at least one of these polymorphic markers is carried out in combination with one or a combination of (i) measuring blood pressure level, (ii) conducting one or a combination of a blood test, a chest X-ray, an electrocardiogram, urinalysis, and an exercise test. The blood test or urinalysis in one embodiment is for measuring cholesterol, potassium, and/or blood sugar levels, and/or for detecting an infection or malfunction.

[0212] The nucleic acids and/or variants described herein, or nucleic acids comprising their complementary sequence, or portions or fragments thereof, may be used as antisense constructs to control gene expression in cells, tissues or organs. Such antisense agents may be useful for therapy of eosinophilia, asthma, myocardial infarction, and/or hypertension. The methodology associated with antisense techniques is well known to the skilled artisan, and is for example described and reviewed in AntisenseDrug Technology: Principles, Strategies, and Applications, Crooke, ed., Marcel Dekker Inc., New York (2001). In general, antisense agents (antisense oligonucleotides) are comprised of single stranded oligonucleotides (RNA or DNA) that are capable of binding to a complimentary nucleotide segment. By binding the appropriate target sequence, an RNA-RNA, DNA-DNA or RNA-DNA duplex is formed. The antisense oligonucleotides are complementary to the sense or coding strand of a gene. It is also possible to form a triple helix, where the antisense oligonucleotide binds to duplex DNA.

[0213] Several classes of antisense oligonucleotide are known to those skilled in the art, including cleavers and blockers. The former bind to target RNA sites, activate intracellular nucleases (e.g., RnaseH or Rnase L), that cleave the target RNA. Blockers bind to target RNA, inhibit protein translation by steric hindrance of the ribosomes. Examples of blockers include nucleic acids, morpholino compounds, locked nucleic acids and methylphosphonates (Thompson, Drug Discovery Today, 7:912-917 (2002)). Antisense oligonucleotides are useful directly as therapeutic agents, and are also useful for determining and validating gene function, for example by gene knock-out or gene knock-down experiments. Antisense technology is further described in Lavery et al., Curr. Opin. Drug Discov. Devel. 6:561-569 (2003), Stephens et al., Curr. Opin. Mol. Ther. 5:118-122 (2003), Kurreck, Eur. J. Biochem. 270:1628-44 (2003), Dias et al., Mol. Cancer Ter. 1:347-55 (2002), Chen, Methods Mol. Med. 75:621-636 (2003), Wang et al., Curr. Cancer Drug Targets 1:177-96 (2001), and Bennett, Antisense Nucleic Acid Drug. Dev. 12:215-24 (2002).

[0214] In certain embodiments, the antisense agent is an oligonucleotide that is capable of binding to a nucleotide segment of a particular gene. Antisense nucleotides can be from 5-500 nucleotides in length, including 5-200 nucleotides, 5-100 nucleotides, 10-50 nucleotides, and 10-30 nucleotides. All integer lengths from 5-500 are specifically contemplated for the present invention, as are all subranges of lengths. In certain preferred embodiments, the antisense nucleotides is from 14-50 nucleotides in length, including 14-40 nucleotides and 14-30 nucleotides. In certain such embodiments, the antisense nucleotide is capable of binding to a nucleotide segment of the a gene selected from the group consisting of ATP9A, ATXN2, BAX, CUX2, IL1RL1, IL33, LBH, LOC441108, PTPN11, RAD50, RAD51L1, SH2B3, SLC22A4, SNX6, TBC1D8, TNKS2, TNXB, BRAP, ACAD10, ALDH2, MAPKAPK5, and ERP29.

[0215] The variants described herein can also be used for the selection and design of antisense reagents that are specific for particular variants. Using information about the variants described herein, antisense oligonucleotides or other antisense molecules that specifically target mRNA molecules that contain one or more variants of the invention can be designed. In this manner, expression of mRNA molecules that contain one or more variant of the present invention (markers and/or haplotypes) can be inhibited or blocked. In one embodiment, the antisense molecules are designed to specifically bind a particular allelic form (i.e., one or several variants (alleles and/or haplotypes)) of the target nucleic acid, thereby inhibiting translation of a product originating from this specific allele or haplotype, but which do not bind other or alternate variants at the specific polymorphic sites of the target nucleic acid molecule.

[0216] As antisense molecules can be used to inactivate mRNA so as to inhibit gene expression, and thus protein expression, the molecules can be used for disease treatment. The methodology can involve cleavage by means of ribozymes containing nucleotide sequences complementary to one or more regions in the mRNA that attenuate the ability of the mRNA to be translated. Such mRNA regions include, for example, protein-coding regions, in particular protein-coding regions corresponding to catalytic activity, substrate and/or ligand binding sites, or other functional domains of a protein.

[0217] The phenomenon of RNA interference (RNAi) has been actively studied for the last decade, since its original discovery in C. elegans (Fire et al., Nature 391:806-11 (1998)), and in recent years its potential use in treatment of human disease has been actively pursued (reviewed in Kim & Rossi, Nature Rev. Genet. 8:173-204 (2007)). RNA interference (RNAi), also called gene silencing, is based on using double-stranded RNA molecules (dsRNA) to turn off specific genes. In the cell, cytoplasmic double-stranded RNA molecules (dsRNA) are processed by cellular complexes into small interfering RNA (siRNA). The siRNA guide the targeting of a protein-RNA complex to specific sites on a target mRNA, leading to cleavage of the mRNA (Thompson, Drug Discovery Today, 7:912-917 (2002)). The siRNA molecules are typically about 20, 21, 22 or 23 nucleotides in length. Thus, one aspect of the invention relates to isolated nucleic acid molecules, and the use of those molecules for RNA interference, i.e. as small interfering RNA molecules (siRNA). In one embodiment, the isolated nucleic acid molecules are 18-26 nucleotides in length, preferably 19-25 nucleotides in length, more preferably 20-24 nucleotides in length, and more preferably 21, 22 or 23 nucleotides in length.

[0218] Another pathway for RNAi-mediated gene silencing originates in endogenously encoded primary microRNA (pri-miRNA) transcripts, which are processed in the cell to generate precursor miRNA (pre-miRNA). These miRNA molecules are exported from the nucleus to the cytoplasm, where they undergo processing to generate mature miRNA molecules (miRNA), which direct translational inhibition by recognizing target sites in the 3' untranslated regions of mRNAs, and subsequent mRNA degradation by processing P-bodies (reviewed in Kim & Rossi, Nature Rev. Genet. 8:173-204 (2007)).

[0219] Clinical applications of RNAi include the incorporation of synthetic siRNA duplexes, which preferably are approximately 20-23 nucleotides in size, and preferably have 3' overlaps of 2 nucleotides. Knockdown of gene expression is established by sequence-specific design for the target mRNA. Several commercial sites for optimal design and synthesis of such molecules are known to those skilled in the art.

[0220] Other applications provide longer siRNA molecules (typically 25-30 nucleotides in length, preferably about 27 nucleotides), as well as small hairpin RNAs (shRNAs; typically about 29 nucleotides in length). The latter are naturally expressed, as described in Amarzguioui et al. (FEBS Lett. 579:5974-81 (2005)). Chemically synthetic siRNAs and shRNAs are substrates for in vivo processing, and in some cases provide more potent gene-silencing than shorter designs (Kim et al., Nature Biotechnol. 23:222-226 (2005); Siolas et al., Nature Biotechnol. 23:227-231 (2005)). In general siRNAs provide for transient silencing of gene expression, because their intracellular concentration is diluted by subsequent cell divisions. By contrast, expressed shRNAs mediate long-term, stable knockdown of target transcripts, for as long as transcription of the shRNA takes place (Marques et al., Nature Biotechnol. 23:559-565 (2006); Brummelkamp et al., Science 296: 550-553 (2002)).

[0221] Since RNAi molecules, including siRNA, miRNA and shRNA, act in a sequence-dependent manner, the variants presented herein (e.g., the markers and haplotypes set forth in Table 3) can be used to design RNAi reagents that recognize specific nucleic acid molecules comprising specific alleles and/or haplotypes (e.g., the alleles and/or haplotypes of the present invention), while not recognizing nucleic acid molecules comprising other alleles or haplotypes. These RNAi reagents can thus recognize and destroy the target nucleic acid molecules. As with antisense reagents, RNAi reagents can be useful as therapeutic agents (i.e., for turning off disease-associated genes or disease-associated gene variants), but may also be useful for characterizing and validating gene function (e.g., by gene knock-out or gene knock-down experiments).

[0222] Delivery of RNAi may be performed by a range of methodologies known to those skilled in the art. Methods utilizing non-viral delivery include cholesterol, stable nucleic acid-lipid particle (SNALP), heavy-chain antibody fragment (Fab), aptamers and nanoparticles. Viral delivery methods include use of lentivirus, adenovirus and adeno-associated virus. The siRNA molecules are in some embodiments chemically modified to increase their stability. This can include modifications at the 2' position of the ribose, including 2'-O-methylpurines and 2'-fluoropyrimidines, which provide resistance to Rnase activity. Other chemical modifications are possible and known to those skilled in the art.

[0223] The following references, incorporated herein by reference, provide a further summary of RNAi, and possibilities for targeting specific genes using RNAi: Kim & Rossi, Nat. Rev. Genet. 8:173-184 (2007), Chen & Rajewsky, Nat. Rev. Genet. 8: 93-103 (2007), Reynolds, et al., Nat. Biotechnol. 22:326-330 (2004), Chi et al., Proc. Natl. Acad. Sci. USA 100:6343-6346 (2003), Vickers et al., J. Biol. Chem. 278:7108-7118 (2003), Agami, Curr. Opin. Chem. Biol. 6:829-834 (2002), Lavery, et al., Curr. Opin. Drug Discov. Devel. 6:561-569 (2003), Shi, Trends Genet. 19:9-12 (2003), Shuey et al., Drug Discov. Today 7:1040-46 (2002), McManus et al., Nat. Rev. Genet. 3:737-747 (2002), Xia et al., Nat. Biotechnol. 20:1006-10 (2002), Plasterk et al., curr. Opin. Genet. Dev. 10:562-7 (2000), Bosher et al., Nat. Cell Biol. 2:E31-6 (2000), and Hunter, Curr. Biol. 9:R440-442 (1999).

[0224] Kits

[0225] Kits useful in the methods of the invention comprise components useful in any of the methods described herein, including for example, primers for nucleic acid hybridization, hybridization probes, restriction enzymes (e.g., for RFLP analysis), allele-specific oligonucleotides, antibodies that bind to an altered polypeptide encoded by a nucleic acid of the invention as described herein (e.g., a genomic segment comprising at least one polymorphic marker and/or haplotype of the present invention) or to a non-altered (native) polypeptide encoded by a nucleic acid of the invention as described herein, reagnts for amplification of a nucleic acid associated with eosinophilia, asthma, myocardial infarction, and/or hypertension reagnts for analyzing the nucleic acid sequence of a nucleic acid associated with eosinophilia, asthma, myocardial infarction, and/or hypertension, reagnts for analyzing the amino acid sequence of a polypeptide encoded by a nucleic acid associated with eosinophilia, asthma, myocardial infarction, and/or hypertension, etc. The kits can for example include necessary buffers, nucleic acid primers for amplifying nucleic acids of the invention (e.g., a nucleic acid segment comprising one or more of the polymorphic markers as described herein), and reagents (including enzymes) for allele-specific detection of the fragments amplified using such primers and necessary enzymes (e.g., DNA polymerase). Additionally, kits can provide reagents for assays to be used in combination with the methods of the invention, e.g., reagents for use with other eosinophilia, asthma, myocardial infarction, and/or hypertension diagnostic assays. The kit may furthermore include a collection of data comprising correlation data between the polymorphic markers assessed by the kit and susceptibility to eosinophilia, asthma myocardial infarction, and/or hypertension.

[0226] In one embodiment, the invention is a kit for assaying a sample from a subject to detect the presence of genetic polymorphisms causative or correlative/associated with eosinophilia, asthma, myocardial infarction, and/or hypertension symptoms associated with eosinophilia, asthma, myocardial infarction, and/or hypertension, or a susceptibility to eosinophilia, asthma, myocardial infarction, and/or hypertension in a subject, wherein the kit comprises reagents necessary for selectively detecting at least one allele of at least one polymorphism of the invention in the genome of the individual. In a particular embodiment, the reagents comprise at least one contiguous oligonucleotide that hybridizes to a fragment of the genome of the individual comprising at least one polymorphism of the invention. In another embodiment, the reagents comprise at least one pair of oligonucleotides that hybridize to opposite strands of a genomic segment obtained from a subject, wherein each oligonucleotide primer pair is designed to selectively amplify a fragment of the genome of the individual that includes at least one polymorphism, wherein the polymorphism is selected from the group consisting of the polymorphisms as listed in Table 3, 4, 6, 7, 10, 13, or 14, and polymorphic markers in linkage disequilibrium therewith (e.g., the markers listed in Table 8). In yet another embodiment the fragment is at least 20 base pairs in size. Such oligonucleotides or nucleic acids (e.g., oligonucleotide primers) can be designed using portions of the nucleic acid sequence flanking polymorphisms (e.g., SNPs or microsatellites) that are indicative of increased or decreased risk of eosinophilia, asthma, myocardial infarction, and/or hypertension. In another embodiment, the kit comprises one or more labeled nucleic acids capable of allele-specific detection of one or more specific polymorphic markers or haplotypes associated with increased or decreased risk of eosinophilia, asthma, myocardial infarction, and/or hypertension, and reagents for detection of the label. Suitable labels include, e.g., a radioisotope, a fluorescent label, an enzyme label, an enzyme co-factor label, a magnetic label, a spin label, an epitope label.

[0227] In particular embodiments, the polymorphic marker or haplotype to be detected by the reagents of the kit comprises reagents for analyzing one or more markers, two or more markers, three or more markers, four or more markers or five or more markers selected from the group consisting of the markers in Table 3, 4, 6, 7, 10, 13, and/or 14. In another embodiment, the marker or haplotype to be detected comprises the markers listed in Table 3. In another embodiment, the marker or haplotype to be detected comprises the markers listed in Table 4, 6 and/or 7. In another embodiment, the marker or haplotype to be detected comprises at least one marker selected from the markers set forth in Table 10 or 13 and/or 14.

[0228] In one preferred embodiment, the kit for detecting the markers of the invention comprises a detection oligonucleotide probe, that hybridizes to a segment of template DNA containing a SNP polymorphisms to be detected, an enhancer oligonucleotide probe and an endonuclease. As explained in the above, the detection oligonucleotide probe comprises a fluorescent moiety or group at its 3' terminus and a quencher at its 5' terminus, and an enhancer oligonucleotide, is employed, as described by Kutyavin et al. (Nucleic Acid Res. 34:e128 (2006)). The fluorescent moiety can be Gig Harbor Green or Yakima Yellow, or other suitable fluorescent moieties. The detection probe is designed to hybridize to a short nucleotide sequence that includes the SNP polymorphism to be detected. In one embodiment, the SNP is anywhere from the terminal residue to -6 residues from the 3' end of the detection probe. The enhancer is a short oligonucleotide probe which hybridizes to the DNA template 3' relative to the detection probe. The probes are designed such that a single nucleotide gap exists between the detection probe and the enhancer nucleotide probe when both are bound to the template. The gap creates a synthetic a basic site that is recognized by an endonuclease, such as Endonuclease IV. The enzyme cleaves the dye off the fully complementary detection probe, but cannot cleave a detection probe containing a mismatch. Thus, by measuring the fluorescence of the released fluorescent moiety, assessment of the presence of a particular allele defined by nucleotide sequence of the detection probe can be performed.

[0229] The detection probe can be of any suitable size, although preferably the probe is relatively short. In one embodiment, the probe is from 5-100 nucleotides in length. In another embodiment, the probe is from 10-50 nucleotides in length, and in another embodiment, the probe is from 12-30 nucleotides in length. Other lengths of the probe are possible and within scope of the skill of the average person skilled in the art.

[0230] In a preferred embodiment, the DNA template containing the SNP polymorphism is amplified by Polymerase Chain Reaction (PCR) prior to detection, and primers for such amplification are included in the reagent kit. In such an embodiment, the amplified DNA serves as the template for the detection probe and the enhancer probe.

[0231] Certain embodiments of the detection probe, the enhancer probe, and/or the primers used for amplification of the template by PCR include the use of modified bases, including modified A and modified G. The use of modified bases can be useful for adjusting the melting temperature of the nucleotide molecule (probe and/or primer) to the template DNA, for example for increasing the melting temperature in regions containing a low percentage of G or C bases, in which modified A with the capability of forming three hydrogen bonds to its complementary T can be used, or for decreasing the melting temperature in regions containing a high percentage of G or C bases, for example by using modified G bases that form only two hydrogen bonds to their complementary C base in a double stranded DNA molecule. In a specific embodiment, modified bases are used in the design of the detection nucleotide probe. Any modified base known to the skilled person can be selected in these methods, and the selection of suitable bases is well within the scope of the skilled person based on the teachings herein and known bases available from commercial sources as known to the skilled person.

[0232] In one of such embodiments, the presence of the marker or haplotype is indicative of a susceptibility (increased susceptibility or decreased susceptibility) to eosinophilia, asthma, myocardial infarction, and/or hypertension. In another embodiment, the presence of the marker or haplotype is indicative of response to a eosinophilia, asthma, myocardial infarction, and/or hypertension therapeutic agent. In another embodiment, the presence of the marker or haplotype is indicative eosinophilia, asthma, myocardial infarction, and/or hypertension prognosis. In yet another embodiment, the presence of the marker or haplotype is indicative of progress of eosinophilia, asthma, myocardial infarction, and/or hypertension treatment. Such treatment may include intervention by surgery, medication or by other means (e.g., lifestyle changes).

[0233] In a further aspect of the present invention, a pharmaceutical pack (kit) is provided, the pack comprising a therapeutic agent and a set of instructions for administration of the therapeutic agent to humans diagnostically tested for one or more variants of the present invention, as disclosed herein. The therapeutic agent can be a small molecule drug, an antibody, a peptide, an antisense or RNAi molecule, or other therapeutic molecules. In one embodiment, an individual identified as a carrier of at least one variant of the present invention is instructed to take a prescribed dose of the therapeutic agent. In one such embodiment, an individual identified as a homozygous carrier of at least one variant of the present invention is instructed to take a prescribed dose of the therapeutic agent. In another embodiment, an individual identified as a non-carrier of at least one variant of the present invention is instructed to take a prescribed dose of the therapeutic agent.

[0234] In certain embodiments, the kit further comprises a set of instructions for using the reagents comprising the kit.

[0235] Nucleic Acids

[0236] The nucleic acids and polypeptides described herein can be used in methods and kits of the invention, as described in the above.

[0237] An "isolated" nucleic acid molecule, as used herein, is one that is separated from nucleic acids that normally flank the gene or nucleotide sequence (as in genomic sequences) and/or has been completely or partially purified from other transcribed sequences (e.g., as in an RNA library). For example, an isolated nucleic acid of the invention can be substantially isolated with respect to the complex cellular milieu in which it naturally occurs, or culture medium when produced by recombinant techniques, or chemical precursors or other chemicals when chemically synthesized. In some instances, the isolated material will form part of a composition (for example, a crude extract containing other substances), buffer system or reagent mix. In other circumstances, the material can be purified to essential homogeneity, for example as determined by polyacrylamide gel electrophoresis (PAGE) or column chromatography (e.g., HPLC). An isolated nucleic acid molecule of the invention can comprise at least about 50%, at least about 80% or at least about 90% (on a molar basis) of all macromolecular species present. With regard to genomic DNA, the term "isolated" also can refer to nucleic acid molecules that are separated from the chromosome with which the genomic DNA is naturally associated. For example, the isolated nucleic acid molecule can contain less than about 250 kb, 200 kb, 150 kb, 100 kb, 75 kb, 50 kb, 25 kb, 10 kb, 5 kb, 4 kb, 3 kb, 2 kb, 1 kb, 0.5 kb or 0.1 kb of the nucleotides that flank the nucleic acid molecule in the genomic DNA of the cell from which the nucleic acid molecule is derived.

[0238] The nucleic acid molecule can be fused to other coding or regulatory sequences and still be considered isolated. Thus, recombinant DNA contained in a vector is included in the definition of "isolated" as used herein. Also, isolated nucleic acid molecules include partially or substantially purified DNA molecules in solution. "Isolated" nucleic acid molecules also encompass in vitro RNA transcripts of the DNA molecules of the invention. An isolated nucleic acid molecule or nucleotide sequence can include a nucleic acid molecule or nucleotide sequence that is synthesized chemically or by recombinant means. Such isolated nucleotide sequences are useful, for example, in the manufacture of the encoded polypeptide, as probes for isolating homologous sequences (e.g., from other mammalian species), for gene mapping (e.g., by in situ hybridization with chromosomes), or for detecting expression of the gene in tissue (e.g., human tissue), such as by Northern blot analysis or other hybridization techniques.

[0239] The invention also pertains to nucleic acid molecules that hybridize under high stringency hybridization conditions, such as for selective hybridization, to a nucleotide sequence described herein (e.g., nucleic acid molecules that specifically hybridize to a nucleotide sequence containing a polymorphic site associated with a marker or haplotype described herein). Such nucleic acid molecules can be detected and/or isolated by allele- or sequence-specific hybridization (e.g., under high stringency conditions). Stringency conditions and methods for nucleic acid hybridizations are well known to the skilled person (see, e.g., Current Protocols in Molecular Biology, Ausubel et al, John Wiley & Sons, (1998), and Kraus and Aaronson, Methods Enzymol., 200:546-556 (1991), the entire teachings of which are incorporated by reference herein.

[0240] The percent identity of two nucleotide or amino acid sequences can be determined by aligning the sequences for optimal comparison purposes (e.g., gaps can be introduced in the sequence of a first sequence). The nucleotides or amino acids at corresponding positions are then compared, and the percent identity between the two sequences is a function of the number of identical positions shared by the sequences (i.e., % identity=# of identical positions/total # of positions.times.100). In certain embodiments, the length of a sequence aligned for comparison purposes is at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, or at least 95%, of the length of the reference sequence. The actual comparison of the two sequences can be accomplished by well-known methods, for example, using a mathematical algorithm. A non-limiting example of such a mathematical algorithm is described in Karlin, S. and Altschul, S., Proc. Natl. Acad. Sci. USA, 90:5873-5877 (1993). Such an algorithm is incorporated into the NBLAST and XBLAST programs (version 2.0), as described in Altschul, S. et al., Nucleic Acids Res., 25:3389-3402 (1997). When utilizing BLAST and Gapped BLAST programs, the default parameters of the respective programs (e.g., NBLAST) can be used. See the website on the world wide web at ncbi.nlm.nih.gov. In one embodiment, parameters for sequence comparison can be set at score=100, wordlength=12, or can be varied (e.g., W=5 or W=20).

[0241] Other examples include the algorithm of Myers and Miller, CABIOS (1989), ADVANCE and ADAM as described in Torellis, A. and Robotti, C., Comput. Appl. Biosci. 10:3-5 (1994); and FASTA described in Pearson, W. and Lipman, D., Proc. Natl. Acad. Sci. USA, 85:2444-48 (1988).

[0242] In another embodiment, the percent identity between two amino acid sequences can be accomplished using the GAP program in the GCG software package (Accelrys, Cambridge, UK).

[0243] The invention also provides isolated nucleic acid molecules that contain a fragment or portion that hybridizes under highly stringent conditions to a nucleic acid that comprises, or consists of, the nucleotide sequence of a gene selected from the group consisting of ATP9A, ATXN2, BAX, CUX2, IL1RL1, IL33, LBH, LOC441108, PTPN11, RAD50, RAD51L1, SH2B3, SLC22A4, SNX6, TBC1D8, TNKS2, TNXB, BRAP, ACAD10, ALDH2, MAPKAPK5, and ERP29, or a nucleotide sequence comprising, or consisting of, the complement of the nucleotide sequence of the gene, wherein the nucleotide sequence comprises at least one polymorphic allele contained in the markers and haplotypes described herein.

[0244] The invention further provides isolated nucleic acid molecules that contain a fragment or portion that hybridizes under highly stringent conditions to a nucleic acid comprising a nucleotide sequence of any of SEQ ID NOs: 1-681, each of which sequences comprise one of the polymorphic markers associated with eosinophilia, asthma, myocardial infarction, or hypertension, as described herein. Such nucleic acid molecules, e.g., oligonucleotide probes, can be used in the manufacture of a diagnostic reagent for diagnosing and/or assessing susceptibility to eosinophilia, asthma, myocardial infarction, or hypertension.

[0245] The nucleic acid fragments of the invention are at least about 15, at least about 18, 20, 23 or 25 nucleotides, and can be 30, 40, 50, 100, 200, 500, 1000, 10,000 or more nucleotides in length. In a specific embodiment, the nucleic acid fragments are 15-500 nucleotides in length.

[0246] The nucleic acid fragments of the invention are used as probes or primers in assays such as those described herein. "Probes" or "primers" are oligonucleotides that hybridize in a base-specific manner to a complementary strand of a nucleic acid molecule. In addition to DNA and RNA, such probes and primers include polypeptide nucleic acids (PNA), as described in Nielsen et al., Science 254:1497-1500 (1991). A probe or primer comprises a region of nucleotide sequence that hybridizes to at least about 15, typically about 20-25, and in certain embodiments about 40, 50 or 75, consecutive nucleotides of a nucleic acid molecule. In one embodiment, the probe or primer comprises at least one allele of at least one polymorphic marker or at least one haplotype described herein, or the complement thereof. In particular embodiments, a probe or primer can comprise 100 or fewer nucleotides; for example, in certain embodiments from 6 to 50 nucleotides, or, for example, from 12 to 30 nucleotides. In other embodiments, the probe or primer is at least 70% identical, at least 80% identical, at least 85% identical, at least 90% identical, or at least 95% identical, to the contiguous nucleotide sequence or to the complement of the contiguous nucleotide sequence. In another embodiment, the probe or primer is capable of selectively hybridizing to the contiguous nucleotide sequence or to the complement of the contiguous nucleotide sequence. Often, the probe or primer further comprises a label, e.g., a radioisotope, a fluorescent label, an enzyme label, an enzyme co-factor label, a magnetic label, a spin label, an epitope label.

[0247] The nucleic acid molecules of the invention, such as those described above, can be identified and isolated using standard molecular biology techniques well known to the skilled person. The amplified DNA can be labeled (e.g., radiolabeled) and used as a probe for screening a cDNA library derived from human cells. The cDNA can be derived from mRNA and contained in a suitable vector. Corresponding clones can be isolated, DNA can obtained following in vivo excision, and the cloned insert can be sequenced in either or both orientations by art-recognized methods to identify the correct reading frame encoding a polypeptide of the appropriate molecular weight. Using these or similar methods, the polypeptide and the DNA encoding the polypeptide can be isolated, sequenced and further characterized.

[0248] In general, the isolated nucleic acid sequences of the invention can be used as molecular weight markers on Southern gels, and as chromosome markers that are labeled to map related gene positions. The nucleic acid sequences can also be used to compare with endogenous DNA sequences in patients to identify polymorphisms causative of or correlated/associated with eosinophilia, asthma, myocardial infarction, and/or hypertension, and as probes, such as to hybridize and discover related DNA sequences or to subtract out known sequences from a sample (e.g., subtractive hybridization). The nucleic acid sequences can further be used to derive primers for genetic fingerprinting, to raise anti-polypeptide antibodies using immunization techniques, and/or as an antigen to raise anti-DNA antibodies or elicit immune responses.

[0249] Antibodies

[0250] The invention also provides antibodies which bind to an epitope comprising either a variant amino acid sequence (e.g., comprising an amino acid substitution) encoded by the variant allele or the reference amino acid sequence encoded by the corresponding non-variant or wild-type allele. For example, if a variant allele encodes an amino acid sequence comprising the epitope CYSTWFEH, wherein the T is an amino acid substitution from the native or wild-type A, the antibody of the invention specifically binds to either the epitope CYSTWFEH or CYSAWFEH. The term "antibody" as used herein refers to an immunoglobulin molecule, or an immunologically active portion of the immunoglobulin molecule, i.e., molecules that contain antigen-binding sites that specifically bind an antigen. A molecule that specifically binds to an epitope is a molecule that binds to that eptiope, but does not substantially bind other epitopes in a sample, e.g., a biological sample, which naturally contains the epitope. Examples of immunologically active portions of immunoglobulin molecules include F(ab) and F(ab')2 fragments which can be generated by treating the antibody with an enzyme such as pepsin.

[0251] The antibody can be polyclonal or monoclonal. The term "monoclonal antibody" or "monoclonal antibody composition", as used herein, refers to a population of antibody molecules that contain only one species of an antigen binding site capable of immunoreacting with a particular epitope of the invention. A monoclonal antibody composition thus typically displays a single binding affinity for a particular epitope of the invention with which it immunoreacts.

[0252] Polyclonal antibodies can be prepared by immunizing a suitable subject with a desired immunogen, e.g., polypeptide comprising the epitope of the invention or a fragment thereof. The antibody titer in the immunized subject can be monitored over time by standard techniques, such as with an enzyme linked immunosorbent assay (ELISA) using immobilized polypeptide. If desired, the antibody molecules directed against the polypeptide can be isolated from the mammal (e.g., from the blood) and further purified by well-known techniques, such as protein A chromatography to obtain the IgG fraction. At an appropriate time after immunization, e.g., when the antibody titers are highest, antibody-producing cells can be obtained from the subject and used to prepare monoclonal antibodies by standard techniques, such as the hybridoma technique originally described by Kohler and Milstein, Nature 256:495-497 (1975), the human B cell hybridoma technique (Kozbor et al., Immunol. Today 4: 72 (1983)), the EBV-hybridoma technique (Cole et al., Monoclonal Antibodies and Cancer Therapy, Alan R. Liss, 1985, Inc., pp. 77-96) or trioma techniques. The technology for producing hybridomas is well known (see generally Current Protocols in Immunology (1994) Coligan et al., (eds.) John Wiley & Sons, Inc., New York, N.Y.). Briefly, an immortal cell line (typically a myeloma) is fused to lymphocytes (typically splenocytes) from a mammal immunized with an immunogen as described above, and the culture supernatants of the resulting hybridoma cells are screened to identify a hybridoma producing a monoclonal antibody that binds a polypeptide of the invention.

[0253] Any of the many well known protocols used for fusing lymphocytes and immortalized cell lines can be applied for the purpose of generating a monoclonal antibody to a polypeptide of the invention (see, e.g., Current Protocols in Immunology, supra; Galfre et al., Nature 266:55052 (1977); R. H. Kenneth, in Monoclonal Antibodies: A New Dimension In Biological Analyses, Plenum Publishing Corp., New York, N.Y. (1980); and Lerner, Yale J. Biol. Med. 54:387-402 (1981)). Moreover, the ordinarily skilled worker will appreciate that there are many variations of such methods that also would be useful.

[0254] Alternative to preparing monoclonal antibody-secreting hybridomas, a monoclonal antibody to a polypeptide of the invention can be identified and isolated by screening a recombinant combinatorial immunoglobulin library (e.g., an antibody phage display library) with the polypeptide to thereby isolate immunoglobulin library members that bind the polypeptide. Kits for generating and screening phage display libraries are commercially available (e.g., the Pharmacia Recombinant Phage Antibody System, Catalog No. 27-9400-01; and the Stratagene SurfZAP.TM. Phage Display Kit, Catalog No. 240612). Additionally, examples of methods and reagents particularly amenable for use in generating and screening antibody display library can be found in, for example, U.S. Pat. No. 5,223,409; PCT Publication No. WO 92/18619; PCT Publication No. WO 91/17271; PCT Publication No. WO 92/20791; PCT Publication No. WO 92/15679; PCT Publication No. WO 93/01288; PCT Publication No. WO 92/01047; PCT Publication No. WO 92/09690; PCT Publication No. WO 90/02809; Fuchs et al., Bio/Technology 9: 1370-1372 (1991); Hay et al., Hum. Antibod. Hybridomas 3:81-85 (1992); Huse et al., Science 246: 1275-1281 (1989); and Griffiths et al., EMBO J. 12:725-734 (1993).

[0255] Additionally, recombinant antibodies, such as chimeric and humanized monoclonal antibodies, comprising both human and non-human portions, which can be made using standard recombinant DNA techniques, are within the scope of the invention. Such chimeric and humanized monoclonal antibodies can be produced by recombinant DNA techniques known in the art.

[0256] In general, antibodies of the invention (e.g., a monoclonal antibody) can be used to isolate a polypeptide by standard techniques, such as affinity chromatography or immunoprecipitation. A polypeptide-specific antibody can facilitate the purification of natural polypeptide from cells and of recombinantly produced polypeptide expressed in host cells. Moreover, an antibody specific for an epitope of the invention can be used to detect the polypeptide (e.g., in a cellular lysate, cell supernatant, or tissue sample) in order to evaluate the abundance and pattern of expression of the polypeptide. Antibodies can be used diagnostically to monitor protein levels in tissue as part of a clinical testing procedure, e.g., to, for example, determine the efficacy of a given treatment regimen. The antibody can be coupled to a detectable substance to facilitate its detection. Examples of detectable substances include various enzymes, prosthetic groups, fluorescent materials, luminescent materials, bioluminescent materials, and radioactive materials. Examples of suitable enzymes include horseradish peroxidase, alkaline phosphatase, beta-galactosidase, or acetylcholinesterase; examples of suitable prosthetic group complexes include streptavidin/biotin and avidin/biotin; examples of suitable fluorescent materials include umbelliferone, fluorescein, fluorescein isothiocyanate, rhodamine, dichlorotriazinylamine fluorescein, dansyl chloride or phycoerythrin; an example of a luminescent material includes luminol; examples of bioluminescent materials include luciferase, luciferin, and aequorin, and examples of suitable radioactive material include 125I, 131I, 35S or 3H.

[0257] Antibodies may also be useful in pharmacogenomic analysis. In such embodiments, antibodies against variant proteins encoded by nucleic acids according to the invention, such as variant proteins that are encoded by nucleic acids that contain at least one polymorphic marker of the invention, can be used to identify individuals that require modified treatment modalities.

[0258] Antibodies can furthermore be useful for assessing expression of variant proteins in disease states, such as in active stages of a disease, or in an individual with a predisposition to a disease related to the function of a protein encoded by a gene associated with eosinophilia, asthma, myocardial infarction, and/or hypertension. Antibodies specific for a variant protein encoded by a nucleic acid that comprises at least one polymorphic marker or haplotype as described herein can be used to screen for the presence of the variant protein, for example to screen for a predisposition to eosinophilia, asthma, myocardial infarction, and/or hypertension, as indicated by the presence of the variant protein.

[0259] Antibodies can be used in other methods. Thus, antibodies are useful as diagnostic tools for evaluating proteins, such as variant proteins of the invention, in conjunction with analysis by electrophoretic mobility, isoelectric point, tryptic or other protease digest, or for use in other physical assays known to those skilled in the art. Antibodies may also be used in tissue typing. In one such embodiment, a specific variant protein has been correlated with expression in a specific tissue type, and antibodies specific for the variant protein can then be used to identify the specific tissue type.

[0260] Subcellular localization of proteins, including variant proteins, can also be determined using antibodies, and can be applied to assess aberrant subcellular localization of the protein in cells in various tissues. Such use can be applied in genetic testing, but also in monitoring a particular treatment modality. In the case where treatment is aimed at correcting the expression level or presence of the variant protein or aberrant tissue distribution or developmental expression of the variant protein, antibodies specific for the variant protein or fragments thereof can be used to monitor therapeutic efficacy.

[0261] The invention further relates to kits comprising the antibodies of the invention in the methods described herein. This includes, but is not limited to, kits for detecting the presence of a variant protein in a test sample. One preferred embodiment comprises antibodies such as a labeled or labelable antibody and a compound or agent for detecting variant proteins in a biological sample, means for determining the amount or the presence and/or absence of variant protein in the sample, and means for comparing the amount of variant protein in the sample with a standard, as well as instructions for use of the kit.

[0262] Computer-Readable Medium, Apparatus

[0263] The methods and information described herein may be implemented, in all or in part, as computer executable instructions on known computer-readable media. For example, the methods described herein may be implemented in hardware. Alternatively, the method may be implemented in software stored in, for example, one or more memories or other computer readable medium and implemented on one or more processors. The processors may be associated with one or more controllers, calculation units and/or other units of a computer system, or implanted in firmware as desired. If implemented in software, the routines may be stored in any computer readable memory such as in RAM, ROM, flash memory, a magnetic disk, a laser disk, or other storage medium, as is also known. Likewise, this software may be delivered to a computing device via any known delivery method including, for example, over a communication channel such as a telephone line, the Internet, a wireless connection, etc., or via a transportable medium, such as a computer readable disk, flash drive, etc.

[0264] More generally, and as understood by those of ordinary skill in the art, the various steps described above may be implemented as various blocks, operations, tools, modules and techniques which, in turn, may be implemented in hardware, firmware, software, or any combination of hardware, firmware, and/or software. When implemented in hardware, some or all of the blocks, operations, techniques, etc. may be implemented in, for example, a custom integrated circuit (IC), an application specific integrated circuit (ASIC), a field programmable logic array (FPGA), a programmable logic array (PLA), etc.

[0265] When implemented in software, the software may be stored in any known computer readable medium such as on a magnetic disk, an optical disk, or other storage medium, in a RAM or ROM or flash memory of a computer, processor, hard disk drive, optical disk drive, tape drive, etc. Likewise, the software may be delivered to a user or a computing system via any known delivery method including, for example, on a computer readable disk or other transportable computer storage mechanism.

[0266] FIG. 6 illustrates an example of a suitable computing system environment 100 on which a system for the steps of the claimed method and apparatus may be implemented. The computing system environment 100 is only one example of a suitable computing environment and is not intended to suggest any limitation as to the scope of use or functionality of the method or apparatus of the claims. Neither should the computing environment 100 be interpreted as having any dependency or requirement relating to any one or combination of components illustrated in the exemplary operating environment 100.

[0267] The steps of the claimed method and system are operational with numerous other general purpose or special purpose computing system environments or configurations. Examples of well known computing systems, environments, and/or configurations that may be suitable for use with the methods or system of the claims include, but are not limited to, personal computers, server computers, hand-held or laptop devices, multiprocessor systems, microprocessor-based systems, set top boxes, programmable consumer electronics, network PCs, minicomputers, mainframe computers, distributed computing environments that include any of the above systems or devices, and the like.

[0268] The steps of the claimed method and system may be described in the general context of computer-executable instructions, such as program modules, being executed by a computer. Generally, program modules include routines, programs, objects, components, data structures, etc. that perform particular tasks or implement particular abstract data types. The methods and apparatus may also be practiced in distributed computing environments where tasks are performed by remote processing devices that are linked through a communications network. In both integrated and distributed computing environments, program modules may be located in both local and remote computer storage media including memory storage devices.

[0269] With reference to FIG. 6, an exemplary system for implementing the steps of the claimed method and system includes a general purpose computing device in the form of a computer 110. Components of computer 110 may include, but are not limited to, a processing unit 120, a system memory 130, and a system bus 121 that couples various system components including the system memory to the processing unit 120. The system bus 121 may be any of several types of bus structures including a memory bus or memory controller, a peripheral bus, and a local bus using any of a variety of bus architectures. By way of example, and not limitation, such architectures include Industry Standard Architecture (ISA) bus, Micro Channel Architecture (MCA) bus, Enhanced ISA (EISA) bus, Video Electronics Standards Association (VESA) local bus, and Peripheral Component Interconnect (PCI) bus also known as Mezzanine bus.

[0270] Computer 110 typically includes a variety of computer readable media. Computer readable media can be any available media that can be accessed by computer 110 and includes both volatile and nonvolatile media, removable and non-removable media. By way of example, and not limitation, computer readable media may comprise computer storage media and communication media. Computer storage media includes both volatile and nonvolatile, removable and non-removable media implemented in any method or technology for storage of information such as computer readable instructions, data structures, program modules or other data. Computer storage media includes, but is not limited to, RAM, ROM, EEPROM, flash memory or other memory technology, CD-ROM, digital versatile disks (DVD) or other optical disk storage, magnetic cassettes, magnetic tape, magnetic disk storage or other magnetic storage devices, or any other medium which can be used to store the desired information and which can accessed by computer 110. Communication media typically embodies computer readable instructions, data structures, program modules or other data in a modulated data signal such as a carrier wave or other transport mechanism and includes any information delivery media. The term "modulated data signal" means a signal that has one or more of its characteristics set or changed in such a manner as to encode information in the signal. By way of example, and not limitation, communication media includes wired media such as a wired network or direct-wired connection, and wireless media such as acoustic, RF, infrared and other wireless media. Combinations of the any of the above should also be included within the scope of computer readable media.

[0271] The system memory 130 includes computer storage media in the form of volatile and/or nonvolatile memory such as read only memory (ROM) 131 and random access memory (RAM) 132. A basic input/output system 133 (BIOS), containing the basic routines that help to transfer information between elements within computer 110, such as during start-up, is typically stored in ROM 131. RAM 132 typically contains data and/or program modules that are immediately accessible to and/or presently being operated on by processing unit 120. By way of example, and not limitation, FIG. 6 illustrates operating system 134, application programs 135, other program modules 136, and program data 137.

[0272] The computer 110 may also include other removable/non-removable, volatile/nonvolatile computer storage media. By way of example only, FIG. 6 illustrates a hard disk drive 140 that reads from or writes to non-removable, nonvolatile magnetic media, a magnetic disk drive 151 that reads from or writes to a removable, nonvolatile magnetic disk 152, and an optical disk drive 155 that reads from or writes to a removable, nonvolatile optical disk 156 such as a CD ROM or other optical media. Other removable/non-removable, volatile/nonvolatile computer storage media that can be used in the exemplary operating environment include, but are not limited to, magnetic tape cassettes, flash memory cards, digital versatile disks, digital video tape, solid state RAM, solid state ROM, and the like. The hard disk drive 141 is typically connected to the system bus 121 through a non-removable memory interface such as interface 140, and magnetic disk drive 151 and optical disk drive 155 are typically connected to the system bus 121 by a removable memory interface, such as interface 150.

[0273] The drives and their associated computer storage media discussed above and illustrated in FIG. 6, provide storage of computer readable instructions, data structures, program modules and other data for the computer 110. In FIG. 6, for example, hard disk drive 141 is illustrated as storing operating system 144, application programs 145, other program modules 146, and program data 147. Note that these components can either be the same as or different from operating system 134, application programs 135, other program modules 136, and program data 137. Operating system 144, application programs 145, other program modules 146, and program data 147 are given different numbers here to illustrate that, at a minimum, they are different copies. A user may enter commands and information into the computer 20 through input devices such as a keyboard 162 and pointing device 161, commonly referred to as a mouse, trackball or touch pad. Other input devices (not shown) may include a microphone, joystick, game pad, satellite dish, scanner, or the like. These and other input devices are often connected to the processing unit 120 through a user input interface 160 that is coupled to the system bus, but may be connected by other interface and bus structures, such as a parallel port, game port or a universal serial bus (USB). A monitor 191 or other type of display device is also connected to the system bus 121 via an interface, such as a video interface 190. In addition to the monitor, computers may also include other peripheral output devices such as speakers 197 and printer 196, which may be connected through an output peripheral interface 190.

[0274] The computer 110 may operate in a networked environment using logical connections to one or more remote computers, such as a remote computer 180. The remote computer 180 may be a personal computer, a server, a router, a network PC, a peer device or other common network node, and typically includes many or all of the elements described above relative to the computer 110, although only a memory storage device 181 has been illustrated in FIG. 6. The logical connections depicted in FIG. 6 include a local area network (LAN) 171 and a wide area network (WAN) 173, but may also include other networks. Such networking environments are commonplace in offices, enterprise-wide computer networks, intranets and the Internet.

[0275] When used in a LAN networking environment, the computer 110 is connected to the LAN 171 through a network interface or adapter 170. When used in a WAN networking environment, the computer 110 typically includes a modem 172 or other means for establishing communications over the WAN 173, such as the Internet. The modem 172, which may be internal or external, may be connected to the system bus 121 via the user input interface 160, or other appropriate mechanism. In a networked environment, program modules depicted relative to the computer 110, or portions thereof, may be stored in the remote memory storage device. By way of example, and not limitation, FIG. 6 illustrates remote application programs 185 as residing on memory device 181. It will be appreciated that the network connections shown are exemplary and other means of establishing a communications link between the computers may be used.

[0276] Although the foregoing text sets forth a detailed description of numerous different embodiments of the invention, it should be understood that the scope of the invention is defined by the words of the claims set forth at the end of this patent. The detailed description is to be construed as exemplary only and does not describe every possibly embodiment of the invention because describing every possible embodiment would be impractical. Numerous alternative embodiments could be implemented, using either current technology or technology developed after the filing date of this patent, which would still fall within the scope of the claims defining the invention.

[0277] While some of the risk evaluation system and method, and other elements, have been described as optionally being implemented in software, they may be implemented in hardware, firmware, etc., and may be implemented by any other processor. Thus, the elements described herein may be implemented in a standard multi-purpose CPU or on specifically designed hardware or firmware such as an application-specific integrated circuit (ASIC) or other hard-wired device as desired, including, but not limited to, the computer 110 of FIG. 6. When implemented in software, the software routine may be stored in any computer readable memory such as on a magnetic disk, a laser disk, or other storage medium, in a RAM or ROM of a computer or processor, in any database, etc. Likewise, this software may be delivered to a user or a diagnostic system via any known or desired delivery method including, for example, on a computer readable disk or other transportable computer storage mechanism or over a communication channel such as a telephone line, the internet, wireless communication, etc. (which are viewed as being the same as or interchangeable with providing such software via a transportable storage medium).

[0278] Thus, many modifications and variations may be made in the techniques and structures described and illustrated herein without departing from the spirit and scope of the invention. Accordingly, it should be understood that the methods and apparatus described herein are illustrative only and are not limiting upon the scope of the invention.

[0279] The following examples further illustrate the invention but should not be construed as in any way limiting its scope.

EXAMPLES

[0280] A genome-wide association scan for sequence variants associating with the number of blood eosinophils was performed. The sequence variants were subsequently assessed for association of these variants with asthma and other inflammatory related diseases. FIG. 1 illustrates the overview of the study design, implementation and results.

[0281] The study was approved by the Icelandic Data Protection Commission and the National Bioethics Committee. All patients signed informed consent and donated blood samples. Personal identities of the patients and biological samples were encrypted by a third party system provided by the Data Protection Commission of Iceland.

[0282] The controls (41% males; mean age 61 years, SD=21) used in this study consisted of individuals from other ongoing genome-wide association studies at deCODE.

[0283] The following is a description of the populations used in the study:

[0284] Iceland--Asthma patients of both sexes over 18 years of age who attended an asthma clinic or emergency room at the National University Hospital of Iceland or the Iceland Medical Center (Laeknasetrid) during the years 1977 to 2008 were recruited. Asthma diagnosis was based on a combination of physician diagnosis, a positive reply to the question: "Has a doctor confirmed your asthma diagnosis?", questioners pertaining to asthma symptoms, and ICD diagnosis when receiving emergency care.

[0285] Atopy status was determined by assessing skin-prick test reactivity (wheal size >3 mm or >50% of the histamine control) to 12 common aeroallergens (Greer Laboratories, Lenoir, N.C., USA), and/or with specific serum IgE levels with UniCAP Phadiotop (Pharmacia Upjohn, Uppsala, Sweden) or RAST (Pharmacia Upjohn). Total serum IgE levels were measured by UniCAP FEIA (Pharmacia Upjohn). All patients provided informed consent and donated blood samples.

[0286] The coronary artery disease groups from Iceland have been described previously (Helgadottir et al., Science 316: 1491 (2007)).

[0287] Australia--The Australian case-control population has been described elsewhere (Kedda et al., J. Allergy Clin. Immunol. 113: 889 (2004)). Briefly, unrelated patients between 18 and 89 years of age with physician diagnosed asthma were recruited into the study. All subjects completed a comprehensive questionnaire and underwent clinical testing including assessment of lung function by spirometry and atopic status by skin prick testing. Atopy was defined as having a wheal reaction to allergen extract >3 mm to at least one of five common aeroallergens. Total serum IgE levels were measured by UniCAP FEIA (Pharmacia Upjohn). The control subjects had no history of asthma and did not undergo clinical testing. All participants gave written informed consent. The study protocol was approved by the Human Research Ethics Committee of the Sir Charles Gairdner Hospital, Western Australia.

[0288] The Netherlands--The Dutch cases have been previously described (Koppelman et al., J. Allergy and Clin. Immunol. 109: 498 (2002); Postma et al., Am. J. Respir. Crit. Care Med. 172: 446 (2005)). Briefly, asthma patients of European ancestry were initially studied between 1962 and 1975. At the time of recruitment and initial testing, all patients had asthma symptoms, were hyperresponsive to histamine (PC.sub.20 histamine <32 mg/ml), and were younger than 45 years of age. Between 1990 and 1999, patients were invited for follow-up tests: including pulmonary function, bronchial responsiveness to histamine, and total and specific serum IgE and skin tests to 16 common aero allergens (Koppelman et al., 2002, supra; Postma et al., 2005, supra). Participants were asked in advance to discontinue asthma or allergy medication, therapy with oral corticosteroids was however continued. The standardized British Medical Council questionnaire was used to assess the onset of symptoms of asthma (wheeze, dyspnea, asthma attacks) and patients were stratified accordingly as having early onset asthma (at age 18 or younger) or adult onset asthma (age 19 or older).

[0289] Controls were derived from Vlagtwedde/Vlaardingen cohort study, which is a general population-based cohort of adult subjects of European ancestry in the Netherlands. The recruitment started in 1965 with a follow-up of over 25 years. Surveys were performed every 3 years, in which information was collected on respiratory symptoms, smoking status, FEV.sub.1, and allergy skin tests, as described (van Diemen et al., Am. J. Respir. Crit. Care Med. 172: 329 (2005)). The Medical Ethics Committee of the University Medical Center Groningen approved the studies, and all participants provided informed consent.

[0290] Korea--The Korean case-control sample has have been described elsewhere (Kim et al., Genes Immun. 8: 369 (2007)). Briefly, cases were recruited at the asthma clinics of two hospitals (Soonchuanhyang University Bucheon Hospital and Seoul Hospital). Asthma diagnosis was based on a history of recent respiratory symptoms and evidence of airway reversibility (greater than 15% increase of FEV following bronchodilation, <10/mg/ml PC20 metahcholine response, or greater than 20% increase of FEV1 following 2 weeks treatment with inhaled steroid). Asthma-free controls were recruited from the spouses of the patients and the general population. All the subjects were skin-prick tested for 24 common inhalant allergens. Atopy was defined as having a wheal reaction with the allergen extract equal to or greater than that with histamine (1 mg/ml) or 3 mm in diameter. Serum levels of total IgE were determined by using ImmunoCAP-specific IgE calibrators of the CAP system. (Pharmacia Diagnostics). The Institutional Review Boards of each of the hospitals approved the study and informed consent was obtained from all subjects. For these subjects eosinophil counts were available.

[0291] Hong Kong--All subjects are of southern Han Chinese ancestry residing in Hong Kong. The cohort consists of diabetes patients from The Prince of Wales Hospital diabetes registry (N=2,659) as well as a non-diabetic cohort consisting of subjects who were ascertained through a cardiovascular risk health screening program (N=597).

[0292] Great Britain--Asthmatic subjects and controls were selected from the Nottingham area from 3 study cohorts recruited over the period 1995-2008. Controls and doctor diagnosed asthmatics were selected from a large random population aged 18-65 (see (Britton et al., Eur. Respir. J. 7: 881 (1994)) for details). Selected matched controls had no history of asthma and had a negative methacholine challenge test. Additional cases of childhood asthma were included by using index cases from the Nottingham sib pair asthma study (Wheatley et al., Hum. Mol. Genet. 11: 2143 (2002)) and additional adult asthma cases were recruited from an ongoing study of asthma severity. Atopy was defined as the presence of 1 or more positive skin tests to common allergens (>2 mm over control). Severity assessment was based on British Thoracic Society guidelines (Thorax 58: i1 (2003)). Steps 1-2 was considered as mild, step 3 was considered as moderate and step 4-5 was considered as severe asthma. All subjects were of European ancestry. Local ethical committee approval was obtained for all 3 studies.

[0293] Germany I--The German case-control population consisted of children (aged 5-18 years) with suspected asthma recruited from the southwestern part of Germany between July 2000 and January 2005 (Henizmann et al., J. Allergy and Clin. Immunol. 112: 735 (2003)). The probands were characterized at the Centre of Pediatrics and Adolescent Medicine, Freiburg, Germany. The diagnosis of asthma was based on a history of respiratory symptoms, the use of anti-asthmatic medication and the presence of bronchial hyperresponsiveness (defined as a fall of at least 15% in baseline FEV.sub.1 after either inhalation of .ltoreq.8 mg/ml histamine or minutes of exercise provocation). Participants were asked in advance to discontinue any asthma or allergy medication before the clinical testing. Atopy status was determined by skin prick tests to 17 common allergens. Measurement of total serum IgE was carried out by using an enzyme allergosorbent test (Phadezym; Pharmacia, Uppsala, Sweden). The control sample consisted of subjects (aged 19-40 years) randomly chosen from the same area in the southwestern part of Germany and children recruited from clinics at the Centre of Pediatrics and Adolescent Medicine, Freiburg, Germany. No medical history was taken, and no medical testing was performed on the adult controls whereas the pediatric controls had no previous history of asthma, recurrent wheezing, atopic dermatitis or atopy. Approval was granted by the Ethical Commission of the University of Freiburg. A statement of informed consent was signed by all participants or signed by their parents in the case of children.

[0294] Germany II--The German sib-pair study consisted of two hundred and one families, consisting of at least two children with confirmed clinical asthma. Phenotyping was carried out by trained staff from more than 20 clinical center using the procedure as described previously (Wjst et al., Genomics 58: 1(1999)). Atopy status was determined by skin prick test for 12 common aero allergens. Specific IgE was measured with 15 RAST assays using the CAP System RAST FEIA (Pharmacia Upjohn. Total serum IgE levels were measured by UniCAP FEIA (Pharmacia Upjohn). The ethics commission of "Nordrhein-Westfalen" approved all study methods and informed consent was obtained from all parents and children. Eosinophil counts were available for these subjects.

[0295] The sib-pairs from the Germany II sample set were analyzed assuming mendelian inheritance under the null hypothesis. Under the alternative transmission probabilities were defined by the multiplicative risk model and the allele frequencies. Un-transmitted parental alleles were used as controls. The number of un-transmitted parental genotypes corresponds to having on average genotyped 204 control individuals.

[0296] Sweden--Individuals 20-44 years of age were recruited from randomly selected population sample in Uppsala, Sweden. This was done as part of the European Community Respiratory Health Survey an internal epidemiologic survey comprising of participants from of 22 nations and 48 centers. Blood samples were collected and measurements included eosinophil counts (Janson et al., J. Allergy Clin. Immunol. 120: 673 (2007)). The eosinophil count was performed at the Department of Clinical Chemistry at Uppsala University Hospital on a Technichon H*I (Technicon, Chemicals Company, Tournai, Belgium).

[0297] Denmark--Asthma subjects and controls were selected and consecutively pooled for the present analysis from three studies at the Copenhagen Research Unit. Participants were aged 14 to 44 years and resided in Copenhagen, Denmark. Subjects were selected if they had doctor diagnosed asthma by a respiratory specialist and had undergone a physical examination and spirometry.

[0298] United States--The coronary artery disease groups from the United States has been described previously (Helgadottir et al., 2007, supra).

[0299] Italy--The subjects from Verona were enrolled into the Verona Heart Study, which is an ongoing study aimed at identifying new risk factors for coronary artery disease (CAD) and myocardial infarction (MI) in a population of subjects with angiographic documentation of their coronary vessels. Details about the enrolment criteria have been described elsewhere (Girelli et al., N. England J. Med. 343: 774 (2000)).

[0300] In brief, the CAD group had angiographically documented severe coronary atherosclerosis, the majority of them being candidates for coronary artery bypass grafting or percutaneous coronary intervention. Control subjects were selected such that they had normal coronary arteries, being submitted to coronary angiography for reasons other than CAD. Controls with history or clinical evidence of atherosclerosis in vascular districts beyond the coronary bed were excluded. Information on MI diagnoses was gathered through medical records showing diagnostic electrocardiogram and enzyme changes, and/or the typical sequelae of MI on ventricular angiography. The study was approved by local Ethical Committee. Informed consent was obtained from all the patients after a full explanation of the study.

[0301] New Zealand--New Zealand CAD patients all had angiographically proven coronary artery stenosis .gtoreq.50% of the vessel internal diameter in at least 1 vessel. The percentage diameter stenosis was visually estimated by an experienced cardiologist as the maximum percentage reduction in the vessel diameter expressed as a percentage of the angiographically normal adjacent vessel.

[0302] The extent of coronary artery disease was defined as the number of vessel territories (left anterior descending, left circumflex and right coronary arteries) with one or more stenoses of .gtoreq.50% and expressed as single, double or triple vessel coronary artery disease. The American College of Cardiology/American Heart Association (ACC/AHA) classification was used to evaluate the morphology of coronary lesions at the index coronary angiogram. MI diagnoses was gathered through medical records showing diagnostic patterns on electrocardiogram and enzyme changes.

[0303] The New Zealand age matched controls had no history of ischemic heart disease, including angina pectoris (Jones et al., Arteriosder Thromb Vasc Biol 28: 764 (2008)). The study was approved by the local ethical committee and all participants gave written informed consent before being recruited.

[0304] The following is a description of the genotyping methods used in the study:

[0305] The Icelandic study participants were genotyped using genotyping systems and specialised software from Illumina (Human Hap300 and Human Hap300-duo+ Bead Arrays, Illumina) (Barrett et al., Nat Genet 38: 659 (2006)). In total, 311,388 single nucleotide polymorphism (SNP) markers, distributed across the human genome, were common to both platforms. For the association analysis, we used 304,226 SNP markers because 7,162 were deemed unusable due to low yield (<95% in at least one sample), deviations from Hardy-Weinberg expectations (P<10.sup.-5 in at least one sample), or discrepancies in genotype frequencies between the arrays. The Dutch study participants were genotyped with the Illumina Human Hap300-duo+Bead Arrays. The American study participants were genotyped with the Human Hap1000 Bead Arrays.

[0306] Single SNP genotyping was carried out on the Centaurus (Nanogen) platform (Kutyavin et al., Nucleic Acids Res 34: e128 (2006)). The quality of each Centaurus SNP assay was evaluated by genotyping each assay in the CEU HapMap samples and comparing the results with the HapMap data. Assays with >1.5% mismatch rate were not used.

[0307] Because of lack of available DNA, only the SNPs showing potential association with asthma were genotyped on the Dutch asthma samples. Because of lack of SNP assay only three asthma samples were typed for rs12619285.

[0308] The following is a description of the quantitative association testing used in the study.

[0309] All blood measurements were standardized using quantile-quantile standardization and then corrected for year of birth (or age), sex, and age at measurement, where available, for each study population separately. In Iceland, year of birth was rounded to five years and used as a factor variable in the correction, but in the other populations a linear term in year of birth was used to correct the measurements.

[0310] For each SNP, a classical linear regression, using the genotype as an additive covariate and the standardized blood measurement as a response, was fit to test for association.

[0311] The test statistics from the Icelandic genome-wide scan were scaled by the method of genomic controls (Devlin et al., Nat Genet 36: 1129-1130; author reply 1131 (2004)) using an estimate of 1.12 for blood eosinophil counts obtained by comparing the observed median of all .chi.2-test statistic to the value predicted by theory (0.675.sup.2). The inflation factor in the combined Icelandic data set was estimated by simulating genotypes through the known Icelandic genealogy as 1.15 for blood eosinophil counts. The inflation factors for the other blood measurements were of similar magnitude.

[0312] Data from different sources were combined by estimating effective sample size from the observed effect sizes and P-values using standard meta-analysis techniques.

[0313] The following is a description of the case-control association testing used in the study.

[0314] The OR for each SNP allele or haplotype was calculated assuming the multiplicative model; i.e. assuming that the risk of a homozyogous carrier, relative to a non-carrier, is the square of the risk of a heterozygous carrier, relative to a non-carrier. Allelic frequencies and OR are presented for the markers. The associated P values were calculated with the standard likelihood ratio .chi..sup.2 statistic as implemented in the NEMO software package (Gretarsdottier et al., Nat Genet 35: 131-138 (e-publication Sep. 21, 2003). Confidence intervals were calculated assuming that the estimate of OR has a log-normal distribution.

[0315] Joint analyses of multiple case-control replication groups were carried out using a Mantel-Haenszel model in which the groups were allowed to have different population frequencies for alleles or genotypes but were assumed to have common relative risks. The tests of heterogeneity were performed by assuming that the allele frequencies were the same in all groups under the null hypothesis, but each group had a different allele frequency under the alternative hypothesis. Joint analyses of multiple groups of cases were performed using an extended Mantel-Haenszel model that corresponds to a polytomous logistic regression using the group indicator as a covariate.

Example 1

[0316] Circulating eosinophils were counted in 110,211 blood samples from 39,142 Icelanders seeking medical care at an Iceland Medical Center (Laeknasetrid), a clinic specializing in internal medicine, between the years 1997 and 2008. The measurements were performed in the Laboratory in Mjodd, RAM, Reykjavik, Iceland. Data from 469 blood samples were removed from the analysis because the sum of differential white blood cell counts were more than 2% from the directly counted number of white blood cells, leaving 109,742 measurements from 39,055 Icelanders. The circulating eosinophil numbers were standardized to a standard normal distribution using quantile-quantile standardization and then adjusted for sex, year of birth, and age at measurement.

[0317] In order to get an estimate for the quality of the adjusted circulating eosinophil numbers, we broke its variance (V) into two components, a between individual component (I) and a within individual, or residual, component (R), such that V=I+R. The I component captures the difference between individuals and is an upper bound for the fraction of variance that can be due to first order genetic factors. The R component captures the measurement variation and other variation observed between repeated measurements of the same individual. In general one would expect to underestimate R, due to measurements usually being taken over relatively short periods of a person's lifespan. R was estimated using the linear mixed-effect model (REF) and by direct estimation of the between measurement variance and estimates of 41% and 39%, respectively, were obtained. An individual in the data measured n times worth 1/(I+R/n) individuals measured only once. An individual measured 2 times is thus roughly equivalent to 1.25 individuals measured only once, and an individual measured 3 times is roughly equivalent to 1.36 individuals. In what follows effect sizes are given in percentages of standard deviation units.

[0318] 9,392 of these were genotyped using the Illumina 317K set of single nucleotide polymorphisms (SNPs) (Illumina, San Diego, Calif.). After quality control, 312,179 SNPs remained (FIG. 2). The top 55 SNPs from the Icelandic genome-wide eosinophil association scan are shown in Table 3.

TABLE-US-00003 TABLE 3 Name of Gene Iceland Discovery Associated Entrez (N = 9,392) SNP/Allele Chr Position.sup.a with SNP Gene ID No. Effect.sup.b P value.sup.c rs11679137 G 2 30,333,531 LBH 81606 5.5 7.9 10.sup.-5 rs1370631 A 2 78,263,516 8.1 1.1 10.sup.-5 rs2164850 C 2 78,277,265 8.4 4.0 10.sup.-6 rs4851400 A 2 101,063,081 TBC1D8 11138 7.0 1.9 10.sup.-5 rs2165427 A 2 101,097,567 TBC1D8 11138 7.2 1.0 10.sup.-5 rs4851411 T 2 101,168,510 5.9 2.0 10.sup.-5 rs1420101 A 2 102,324,148 IL1RL1 9173 6.4 5.9 10.sup.-7 rs12998521 T 2 102,340,849 5.6 1.1 10.sup.-5 rs1559930 A 2 204,709,808 5.1 7.8 10.sup.-5 rs6730424 T 2 204,739,314 5.9 2.9 10.sup.-5 rs12619285 A 2 213,532,290 6.8 1.5 10.sup.-6 rs6439132 T 3 129,732,825 6.2 2.7 10.sup.-5 rs4857855 C 3 129,743,240 8.3 3.7 10.sup.-7 rs7635061 A 3 129,755,171 7.2 5.3 10.sup.-7 rs2335050 C 3 129,761,493 7.9 9.0 10.sup.-7 rs2532072 C 4 15,511,238 7.0 2.2 10.sup.-5 rs4629469 G 4 36,095,442 5.2 4.7 10.sup.-5 rs2416257 G 5 110,463,389 WDR36 134430 7.9 8.9 10.sup.-6 rs184941 G 5 110,567,791 7.2 6.0 10.sup.-7 rs11950562 A 5 131,680,428 SLC22A4 6583 5.3 2.1 10.sup.-5 rs272893 A 5 131,690,961 SLC22A4 6583 5.9 4.9 10.sup.-6 rs1050152 C 5 131,704,219 SLC22A4 6583 5.9 3.4 10.sup.-6 rs2188962 C 5 131,798,704 LOC441108 441108 6.2 1.2 10.sup.-6 rs4143832 A 5 131,890,876 10.0 8.0 10.sup.-9 rs2079103 T 5 131,892,405 8.6 1.5 10.sup.-8 rs2244012 C 5 131,929,124 RAD50 10111 9.0 6.6 10.sup.-8 rs2897443 A 5 131,957,493 RAD50 10111 8.8 1.3 10.sup.-7 rs6871536 C 5 131,997,773 RAD50 10111 8.9 8.0 10.sup.-8 rs2269426 T 6 32,184,477 TNXB 7148 6.0 6.4 10.sup.-6 rs9494145 T 6 135,474,245 7.4 3.8 10.sup.-7 rs273148 G 7 41,478,264 5.5 1.9 10.sup.-5 rs748065 A 8 21,734,049 6.0 1.0 10.sup.-5 rs11778166 C 8 22,985,295 6.9 1.1 10.sup.-7 rs1412426 T 9 6,178,652 6.0 5.8 10.sup.-6 rs992969 A 9 6,199,697 6.8 2.6 10.sup.-6 rs3939286 A 9 6,200,099 IL-33 6.8 2.5 10.sup.-6 rs2663041 T 10 49,777,543 WDFY4 57705 5.7 6.1 10.sup.-6 rs12411706 G 10 93,590,282 TNKS2 80351 7.7 2.4 10.sup.-5 rs1265566 T 12 110,200,759 CUX2 23316 6.3 2.2 10.sup.-6 rs3184504 T 12 110,368,991 SH2B3 10019 7.7 2.0 10.sup.-9 rs653178 G 12 110,492,139 ATXN2 6311 7.7 1.6 10.sup.-9 rs11066320 A 12 111,390,798 PTPN11 5781 7.7 3.8 10.sup.-9 rs233722 C 12 111,515,857 6.2 3.6 10.sup.-6 rs233716 G 12 111,524,326 5.7 1.9 10.sup.-5 rs7315519 A 12 111,677,310 5.9 3.4 10.sup.-6 rs4773225 G 13 110,043,093 5.2 3.0 10.sup.-5 rs7150454 G 14 67,835,411 RAD51L1 5890 7.0 4.7 10.sup.-6 rs927220 C 14 67,837,725 RAD51L1 5890 5.8 1.7 10.sup.-5 rs6503609 A 17 36,596,245 5.5 1.2 10.sup.-5 rs7223150 G 17 51,013,132 6.2 3.3 10.sup.-5 rs9954643* G 18 25,127,511 8.4 6.1 10.sup.-5 rs231228 C 19 40,960,611 SNX26 115703 6.3 1.5 10.sup.-5 rs1805419 G 19 54,150,916 BAX 581 6.9 7.9 10.sup.-7 rs1467412 A 20 49,678,608 ATP9A 10079 5.3 2.2 10.sup.-5 rs2426358 C 20 49,711,704 ATP9A 10079 5.7 1.0 10.sup.-5 .sup.aPosition in build 36 coordinates. .sup.bEffect in percentage standard units. .sup.cCorrected using a genome-wide inflation factor of 1.10. *rs9954643 is also known as rs12456181

[0319] 4,458 more Icelanders were analyzed as a follow-up (replication) set to validate the 36 SNPs having the highest signal identified in the discovery step. Blood eosinophils of Icelanders in the follow-up (replication) set were counted at the same laboratory as for the ones in the discovery set, for an average of 1.8 counts per individual.

[0320] The replication sample was selected to have more extreme eosinophil values than the normal population (FIG. 3) and its variance was 1.40 times greater than for the overall measured populations. Selecting extreme valued individuals for genotyping is known to inflate effect estimates. If effect sizes are small (as is the case in the present application), then selecting individuals with absolute values above a certain threshold will inflate effect estimates by approximately the same amount as the variance in the inflated sample is inflated. All effect estimates were therefore deflated in the replication sample by a factor of 1.40.

[0321] Single SNP genotyping assays could be created for 32 out of the 36 selected SNPs. Two of the failing SNP assays had a good surrogate in the set of 32 functioning SNP assays. The results of the follow-up (replication) set are shown in Table 4.

TABLE-US-00004 TABLE 4 Iceland Replication (N = 4,458) SNP/Allele N Effect.sup.a P value.sup.b rs11679137 G 4,437 -0.9 0.71 rs2164850 C 4,437 3.1 0.33 rs2165427 A 4,422 3.4 0.23 rs1420101 A 4,378 14.8 8.5 10.sup.-11 rs6730424 T 4,435 2.2 0.37 rs12619285 A 4,439 5.7 0.024 rs4857855 C 4,390 13.4 3.6 10.sup.-6 rs7635061 A 4,441 9.4 0.00018 rs2532072 C 4,454 -4.8 0.098 rs4629469 G 4,435 -2.3 0.31 rs2416257 G 4,403 8.6 0.0070 rs184941 G 4,442 4.2 0.098 rs4143832 A 4,431 17.2 1.0 10.sup.-8 rs2079103 T 4,414 12.9 1.2 10.sup.-6 rs2269426 T 4,440 7.2 0.0023 rs9494145 T 4,400 9.3 0.00037 rs273148 G 4,308 2.3 0.32 rs748065 A 4,436 3.8 0.11 rs11778166 C 4,430 1.5 0.50 rs1412426 T 4,428 6.7 0.0040 rs3939286 A 4,361 3.9 0.13 rs2663041 T 4,426 3.2 0.15 rs12411706 G assay failed rs3184504 T 4,425 14.9 8.5 10.sup.-11 rs653178 G 4,432 14.4 2.8 10.sup.-10 rs11066320 A 4,379 12.7 4.8 10.sup.-08 rs233722 C assay failed rs233716 G assay failed rs4773225 G 4408 1.1 0.61 rs7150454 G 4439 3.7 0.17 rs6503609 A 4393 -0.9 0.69 rs7223150 G 4436 0.2 0.93 rs9954643 G 3932 0.8 0.77 rs231228 C 4433 -0.5 0.86 rs1805419 G assay failed rs2426358 C 4427 2.3 0.30 .sup.aEffect in percentage of standard units. .sup.bUncorrected P value.

[0322] Fifteen of the 32 tested SNPs at 10 distinct loci were chosen for further study in 1,411 individuals from the United States, 387 from Germany, 419 from Sweden and 484 from Italy. The effect of the SNPs correlating with blood eosinophil counts were also examined in a set of 5,212 East Asian individuals: 1,958 from the Korea and 3,254 from Hong Kong. An overview of the subjects (Mean M) of each of sample set with available circulating eosinophil numbers is shown in Table 5 and the results of the genome-wide search for SNPs associating with blood eosinophil count and the replication effort are shown in Tables 6 and 7.

TABLE-US-00005 TABLE 5 Sample set N YOB/AGE (SEM) Male % Mean M Iceland Discovery 9,392 1943 (18) 36% 2.2 Iceland Replication 4,458 1950 (17) 40% 1.8 Iceland not genotyped 25,205 1957 (19) 40% 1.6 Germany II 387 40 (6) 51% 1 US, Durham 1,411 1943 (12) 62% 1 Sweden 462 34 (7) 64% 1 Verona, Italy 484 58 (11) 82% 1 Korea 1,958 1957 (16) 40% 1 Hong Kong 3,254 54 (14) 48% 1 N, the number of subjects; YOB/AGE, the mean year of birth or age; SEM, standard error of the mean; Male %, the fraction of male individuals; GM M, the geometric mean number of times eosinophils were counted for each subject.

TABLE-US-00006 TABLE 6 Iceland Iceland Discovery Replication SNP/ (N = 9,392) (N = 4,458) Allele Chr Position Freq.sup.a Gene Effect P value Effect.sup.b P value SNPs satisfying the criteria for genome-wide significance rs1420101 2 102,324,148 41 IL1RL1 6.4 2.2 10.sup.-6 11.0 8.5 10.sup.-11 A.sup.c rs12619285 G 2 213,532,290 74 IKZF2 6.8 5.1 10.sup.-6 4.2 0.024 rs4857855 T 3 129,743,240 82 GATA2 8.3 1.5 10.sup.-6 9.9 3.6 10.sup.-6 rs4143832 C 5 131,890,876 16 IL5 10.0 4.6 10.sup.-8 12.8 1.0 10.sup.-8 rs9494145 T 6 135,474,245 33 MYB 7.4 1.5 10.sup.-6 6.9 0.00037 rs3184504 T 12 110,368,991 38 SH2B3 7.7 1.3 10.sup.-8 11.1 8.5 10.sup.-11 SNPs that did not satisfy the criteria for genome-wide significance rs2416257 G 5 110,463,389 85 WDR36 7.9 2.5 10.sup.-5 6.4 0.0070 rs2269426 T 6 32,184,477 76 MHC 6.0 1.9 10.sup.-5 5.3 0.0023 rs748065 A 8 21,734,049 69 GFRA2 6.0 2.9 10.sup.-5 2.8 0.11 rs3939286 A 9 6,200,099 25 IL33 6.8 8.2 10.sup.-6 2.9 0.13 Combined Other European European (N = 16,551) East Asian SNP/ (N = 2,701) Effect (95% (N = 5,212) Allele Effect P value CI) P value Freq Effect P value SNPs satisfying the criteria for genome-wide significance rs1420101 5.0 0.068 7.3 (5.4, 9.2) .sup. 7.8 10.sup.-14 37 4.7 0.051 A.sup.c rs12619285 G 6.7 0.023 6.1 (3.8, 8.3) 1.2 10.sup.-7 36 5.9 0.017 rs4857855 T 12.7 0.00031 9.4 (6.9, 11.9) .sup. 2.0 10.sup.-13 70 8.5 0.0017 rs4143832 C 2.3 0.50 9.0 (6.5, 11.5) .sup. 2.7 10.sup.-12 17 10.2 0.0039 rs9494145 T 0.5 0.87 6.1 (3.8, 8.3) 1.0 10.sup.-7 70 2.9 0.34 rs3184504 T 10.1 0.00013 8.8 (6.8, 10.7) .sup. 6.6 10.sup.-19 .sup. 0.sup.d SNPs that did not satisfy the criteria for genome-wide significance rs2416257 G 4.7 0.23 6.8 (4.0, 9.6) 1.8 10.sup.-6 95 -0.8 0.87 rs2269426 T 1.1 0.68 4.9 (2.9, 7.0) 2.2 10.sup.-6 30 -0.4 0.89 rs748065 A 2.2 0.44 4.5 (2.3, 6.7) 4.9 10.sup.-5 43 -0.5 0.84 rs3939286 A 3.9 0.21 5.3 (2.9, 7.7) 1.1 10.sup.-5 3 -5.5 0.55 Results of genome-wide search for SNPs associating with blood eosinophil count and replication effort. Effects are given in percentage of standard units. .sup.aFrequency in Iceland. .sup.bBecause of the extreme value selection in the Icelandic replication, the corresponding estimates have been deflated by a factor of 1.40. .sup.cBecause of assay quality issues, the reported results for the non-Icelandic samples are based on the T allele of rs950880 (R.sup.2 = 0.96 in the CEU HapMap samples). .sup.dThe frequency of the rs3184504 too low in the East Asians for our SNP assay to yield reliable genotypes.

TABLE-US-00007 TABLE 7 Iceland Iceland Discovery Replication (N = 9,392) (N = 4,458) SNP/Allele Chr Position Freq.sup.a Gene Effect.sup.b P value Effect.sup.b P value rs7635061 G 3 129,755,171 75 GATA2 7.2 2.0 10.sup.-6 9.4 0.00018 rs184941 G 5 110,463,389 85 WDR36 7.2 2.3 10.sup.-6 4.2 0.098 rs2079103 T 5 131,892,405 21 IL5 8.6 8.2 10.sup.-8 12.9 1.2 10.sup.-6 rs1412426 T 9 6,178,652 33 IL33 6.0 1.7 10.sup.-5 6.7 0.0040 rs653178 G 12 110,492,139 39 SH2B3 7.7 1.1 10.sup.-8 14.4 2.8 10.sup.-0 Combined Other European European (N = 16,551) Korean (N = 2,701) Effect.sup.b (N = 5,212) SNP/Allele Effect.sup.b P value (95% CI) P value Freq Effect.sup.b P value rs7635061 G 11.1 0.00011 8.5 (6.1, 10.9) .sup. 4.1 10.sup.-12 58 6.3 0.0076 rs184941 G -0.1 0.98 5.2 (2.7, 7.6) 3.5 10.sup.-5 87 -3.6 0.20 rs2079103 T -0.3 0.93 7.9 (5.3, 10.4) 1.2 10.sup.-9 35 3.4 0.16 rs1412426 T -1.6 0.56 4.9 (2.7, 7.1) 1.8 10.sup.-5 5 -2.0 0.69 rs653178 G 9.8 0.00020 9.7 (7.5, 11.9) .sup. 2.1 10.sup.-18 .sup. 0.sup.c Effects are given in percentage of standard units. .sup.aFrequency in Iceland. .sup.bEffect in percentage of standard units. .sup.cThe frequency of the chromosome 12 SNPs is too low in the Koreans for our SNP assay to yield reliable genotypes.

[0323] As shown in Tables 4 and 5, combining the results from the discovery and follow-up sets variants at six out of ten loci satisfied our criteria for genome-wide significance (P<1.610.sup.-7.apprxeq.0.05/312.179) and had a consistent direction of correlation between the sample sets. SNPs at four out of the ten loci replicated nominally in the East Asians and the SNPs at three out of the remaining six loci had minor allele frequency less than 5%, leading to little replication power.

[0324] Risk (odds ratio, OR) was calculated for the SNPs of Table 4 by comparing the top 5% of the eosionophil count distribution to the lowest 5%. Also, risk for genotyped surrogates with r2>0.2 to the anchor marker were determined. The calculated risk for the anchor marker and surrogate markers are shown in Table 8.

TABLE-US-00008 TABLE 8 SNP in LD with Anchor Anchor qtl p- 5pct p- SNP Allele r.sup.2 SNP Chr Position value qtl_effect value 5pc OR rs12475055 2 0.239147 rs1420101 C02 102245323 7.49E-05 0.049484 0.0181384 1.25137 rs4399750 2 0.645931 rs1420101 C02 102284220 0.004981 0.035528 0.123172 1.157533 rs11685424 1 0.587682 rs1420101 C02 102293413 0.004254 0.036156 0.11363 1.161918 rs1420101 1 1 rs1420101 C02 102324148 5.87E-07 0.064069 0.00678028 1.30132 rs1921622 1 0.39006 rs1420101 C02 102332499 0.00043 0.044981 0.351245 1.093278 rs10204137 1 0.297189 rs1420101 C02 102334644 6.63E-05 0.050735 0.0194379 1.254094 rs10192157 2 0.297189 rs1420101 C02 102334788 6.77E-05 0.050716 0.0218273 1.248735 rs10206753 4 0.297189 rs1420101 C02 102334794 6.17E-05 0.050949 0.0194379 1.25409 rs12998521 4 0.798263 rs1420101 C02 102340849 1.07E-05 0.056065 0.0226378 1.24675 rs1035130 1 0.850885 rs1420101 C02 102367834 2.76E-05 0.056171 0.0122381 1.291096 rs4851004 2 0.241829 rs1420101 C02 102375969 0.000456 0.043819 0.0174058 1.253672 rs2287033 1 0.241829 rs1420101 C02 102377669 0.000518 0.04338 0.0173021 1.25426 rs1420094 3 0.241829 rs1420101 C02 102382119 0.00046 0.04379 0.018053 1.25196 rs3755266 2 0.241829 rs1420101 C02 102409144 0.000306 0.04515 0.0151522 1.259726 rs2310300 1 0.241829 rs1420101 C02 102415506 0.000349 0.044715 0.0161837 1.256869 rs10490204 3 0.812829 rs1420101 C02 102422966 4.32E-05 0.054888 0.0342592 1.241005 rs3771150 4 0.850885 rs1420101 C02 102427283 3.46E-05 0.055636 0.0275247 1.25229 rs11465730 3 0.444093 rs1420101 C02 102433290 0.105871 0.020429 0.312456 1.10074 rs975381 1 0.252874 rs12619285 C02 213524876 0.040956 0.02606 0.248138 1.118912 rs12619285 1 1 rs12619285 C02 213532290 1.48E-06 0.068321 0.0192685 1.281924 rs7577413 3 0.331897 rs12619285 C02 213564411 0.01136 0.031832 0.364715 1.08974 rs4673714 3 0.219601 rs12619285 C02 213566402 0.041971 0.02565 0.390435 1.08655 rs1871946 1 0.319792 rs12619285 C02 213587652 0.000226 0.047591 0.0922913 1.178591 rs2335052 3 0.725275 rs4857855 C03 129687641 0.000164 0.06537 0.0232475 1.35443 rs6439132 4 0.665622 rs4857855 C03 129732825 2.74E-05 0.061519 0.000345149 1.49797 rs9854612 3 0.559229 rs4857855 C03 129739904 0.00045 0.083888 0.000937209 1.94754 rs4857855 2 1 rs4857855 C03 129743240 3.70E-07 0.082629 0.00055014 1.538324 rs7635061 1 0.403371 rs4857855 C03 129755171 5.35E-07 0.071823 0.000234859 1.503003 rs2335050 2 0.733349 rs4857855 C03 129761493 8.98E-07 0.079172 0.000834332 1.513433 rs6785206 3 0.251445 rs4857855 C03 129894714 0.03256 0.074033 0.111669 1.58835 rs2416257 3 1 rs2416257 C05 110463389 8.86E-06 0.079062 0.018729 1.36234 rs10051830 3 0.201183 rs2416257 C05 110480744 0.00251 0.038347 0.441189 1.0763 rs1037684 4 0.441687 rs2416257 C05 110502060 0.000958 0.047365 0.0997369 1.19258 rs390047 2 0.38914 rs2416257 C05 110502091 0.000285 0.051192 0.0390389 1.243458 rs9326826 3 0.331984 rs2416257 C05 110522145 0.014129 0.033258 0.218605 1.13444 rs1072056 3 0.423077 rs2416257 C05 110532014 0.018201 0.034008 0.276878 1.124786 rs184941 3 0.405594 rs2416257 C05 110567791 6.04E-07 0.071615 0.0206139 1.29106 rs1469441 3 0.581435 rs2416257 C05 110573038 0.001599 0.062255 0.0506812 1.34117 rs919334 4 0.25641 rs2416257 C05 110581301 0.000579 0.044652 0.107527 1.17247 rs273901 2 0.257589 rs4143832 C05 131722259 5.60E-05 0.053792 0.101138 1.17946 rs1016988 2 0.356148 rs4143832 C05 131772473 0.000284 0.057209 0.148547 1.19418 rs1003533 4 0.323815 rs4143832 C05 131783550 0.000514 0.054876 0.146702 1.19415 rs4143832 1 1 rs4143832 C05 131890876 7.95E-09 0.099564 0.000650341 1.567517 rs2079103 4 0.627184 rs4143832 C05 131892405 1.52E-08 0.086118 0.00147498 1.45091 rs743562 4 0.260204 rs4143832 C05 131900282 0.290966 0.013573 0.0746446 1.18927 rs2244012 2 0.429729 rs4143832 C05 131929124 6.56E-08 0.089869 0.00312604 1.456327 rs2897443 1 0.429729 rs4143832 C05 131957493 1.27E-07 0.08847 0.00452021 1.439546 rs6871536 2 0.429729 rs4143832 C05 131997773 7.98E-08 0.089217 0.003705 1.447097 rs2844477 3 0.258205 rs2269426 C06 31686751 0.751533 0.007024 0.977307 1.00526 rs2260000 2 0.258205 rs2269426 C06 31701455 0.007214 0.035499 0.104314 1.175543 rs1077393 2 0.290127 rs2269426 C06 31718508 0.001985 0.038796 0.337422 1.095618 rs1052486 2 0.279809 rs2269426 C06 31718665 0.002762 0.037552 0.38317 1.086829 rs494620 1 0.214299 rs2269426 C06 31946692 0.695574 0.005026 0.657264 1.043966 rs614549 4 0.244882 rs2269426 C06 31948604 0.377069 0.019471 0.901842 0.977895 rs2736428 1 0.204766 rs2269426 C06 31951903 0.092212 0.02285 0.420892 1.085402 rs2763982 3 0.218661 rs2269426 C06 31980530 0.917969 0.002262 0.891305 0.975592 rs2734335 4 0.217984 rs2269426 C06 32001923 0.115164 0.019663 0.775684 1.02738 rs537160 2 0.236625 rs2269426 C06 32024379 0.857659 0.003779 0.961881 0.991597 rs4151657 2 0.233123 rs2269426 C06 32025519 0.014 0.034177 0.492992 1.07454 rs2072633 2 0.276683 rs2269426 C06 32027557 0.126652 0.019057 0.191148 1.132188 rs630379 3 0.244796 rs2269426 C06 32030233 0.03538 0.027705 0.483943 1.072763 rs437179 3 0.240037 rs2269426 C06 32036993 0.038965 0.027035 0.507567 1.068524 rs592229 4 0.382211 rs2269426 C06 32038420 0.350658 0.011601 0.780244 1.0269 rs6941112 1 0.321092 rs2269426 C06 32054593 0.001038 0.046813 0.224357 1.139853 rs389883 1 0.248944 rs2269426 C06 32055439 0.033111 0.027927 0.434377 1.081725 rs12198173 1 0.203931 rs2269426 C06 32134786 0.19315 0.030749 0.0998665 1.350372 rs2239689 4 0.277349 rs2269426 C06 32138262 0.001339 0.044466 0.107304 1.18271 rs7766862 1 0.271353 rs2269426 C06 32140985 0.326675 0.022611 0.204373 1.268184 rs2071295 1 0.303031 rs2269426 C06 32146678 0.001408 0.044264 0.113469 1.179278 rs185819 2 0.582947 rs2269426 C06 32158045 0.000103 0.048646 0.00699072 1.291846 rs2071293 4 0.303031 rs2269426 C06 32170665 0.354246 0.021534 0.276802 1.22892 rs13199524 4 0.203931 rs2269426 C06 32174743 0.19315 0.030749 0.0998665 1.35037 rs12153855 2 0.272544 rs2269426 C06 32182782 0.186337 0.029079 0.133139 1.284104 rs2269426 4 1 rs2269426 C06 32184477 6.36E-06 0.060424 0.00224097 1.36308 rs8111 1 0.560811 rs2269426 C06 32191153 0.000124 0.056517 0.0332117 1.268096 rs9267803 4 0.560811 rs2269426 C06 32209740 0.080187 0.043081 0.186426 1.30003 rs4713505 4 0.560811 rs2269426 C06 32212979 0.12762 0.036876 0.19102 1.2907 rs1053924 3 0.364732 rs2269426 C06 32228693 0.023631 0.029171 0.66142 1.04409 rs2269424 4 0.332172 rs2269426 C06 32240211 0.038244 0.052741 0.0587999 1.46981 rs2269423 3 0.424223 rs2269426 C06 32253685 0.000866 0.041746 0.23546 1.119352 rs1035798 4 0.332172 rs2269426 C06 32259200 0.003333 0.045356 0.17021 1.17417 rs1800624 1 0.295681 rs2269426 C06 32260365 0.067244 0.046251 0.0930099 1.410734 rs2071277 3 0.272032 rs2269426 C06 32279661 0.127458 0.019145 0.481086 1.07005 rs9267833 2 0.290949 rs2269426 C06 32285878 0.000774 0.051018 0.0891845 1.21624 rs2071286 1 0.26454 rs2269426 C06 32287874 0.001682 0.052094 0.122651 1.214475 rs394657 3 0.260445 rs2269426 C06 32295001 0.002469 0.039145 0.101476 1.17534 rs422951 3 0.234519 rs2269426 C06 32296361 0.011295 0.032556 0.332637 1.09962 rs1547247 3 0.314304 rs9494145 C06 135432529 0.014643 0.033524 0.0610602 1.2122 rs9399137 4 0.522581 rs9494145 C06 135460711 8.50E-05 0.055984 0.00468326 1.35603 rs9376092 2 0.654676 rs9494145 C06 135468837 7.88E-05 0.054802 0.0127758 1.29938 rs10484494 2 0.263158 rs9494145 C06 135471786 0.061091 0.067424 0.421827 1.228758 rs9494145 4 1 rs9494145 C06 135474245 3.76E-07 0.074015 0.00222666 1.3988 rs2026937 1 0.224511 rs9494145 C06 135480956 0.036028 0.026449 0.161419 1.142203 rs12663543 1 0.280928 rs9494145 C06 135559307 0.006147 0.050495 0.178681 1.211381 rs748065 1 1 rs748065 C08 21734049 1.01E-05 0.06047 0.0520788 1.22613 rs922504 2 0.636364 rs748065 C08 21737990 0.000403 0.045145 0.0605276 1.200818 rs10124250 4 0.503722 rs3939286 C09 6151686 0.001217 0.04104 0.580128 1.05506 rs10119713 1 0.503722 rs3939286 C09 6153823 0.001034 0.04161 0.578224 1.055417 rs2079 4 0.214206 rs3939286 C09 6156653 0.021313 0.030353 0.902469 1.01244 rs2890704 4 0.252485 rs3939286 C09 6174165 0.031614 0.044502 0.233732 1.21539 rs1412426 4 0.728507 rs3939286 C09 6178652 5.77E-06 0.060038 0.0594361 1.21116 rs1342326 3 0.513678 rs3939286 C09 6180076 0.000472 0.06134 0.543933 1.082585 rs992969 1 1 rs3939286 C09 6199697 2.57E-06 0.067837 0.122798 1.185049 rs3939286 1 1 rs3939286 C09 6200099 2.53E-06 0.06785 0.117254 1.187938 rs928413 3 1 rs3939286 C09 6203387 3.36E-05 0.05903 0.142429 1.17301 rs2066362 4 0.399291 rs3939286 C09 6209176 0.004897 0.050724 0.500481 1.09477 rs4766522 4 0.275346 rs3184504 C12 109877902 0.006323 0.034669 0.0517 1.20732 rs4509829 2 0.275346 rs3184504 C12 109880996 0.006704 0.034346 0.0484383 1.210761 rs991817 4 0.275346 rs3184504 C12 109894920 0.014281 0.031115 0.0911361 1.17795 rs10774613 2 0.2646 rs3184504 C12 110030548 0.008063 0.034231 0.0526009 1.206557 rs1265566 4 0.259762 rs3184504 C12 110200759 2.19E-06 0.063199 8.38E-05 1.49439 rs7970490 1 0.221355 rs3184504 C12 110240821 0.019182 0.030961 0.0675107 1.203483 rs3847953 3 0.263113 rs3184504 C12 110249847 0.01044 0.034102 0.137601 1.16355 rs10774623 1 0.240386 rs3184504 C12 110317972 0.01452 0.03438 0.0139414 1.309524 rs3184504 4 1 rs3184504 C12 110368991 1.95E-09 0.07701 2.95E-06 1.57496 rs2301621 3 0.219935 rs3184504 C12 110379655 0.023694 0.031916 0.0270116 1.27651 rs6490162 4 0.219935 rs3184504 C12 110425503 0.051138 0.027604 0.0493003 1.24371 rs607316 3 0.200363 rs3184504 C12 110453831 0.041421 0.028939 0.0449431 1.24978 rs616668 1 0.200363 rs3184504 C12 110458663 0.049987 0.027968 0.0578074 1.237559 rs648997 3 0.370996 rs3184504 C12 110461159 0.034261 0.038832 0.114713 1.25933 rs653178 3 1 rs3184504 C12 110492139 1.55E-09 0.077219 2.64E-06 1.57413 rs601663 4 0.226059 rs3184504 C12 110607667 0.012877 0.032481 0.0906146 1.18587

Example 2

[0325] This example demonstrates whether the eosinophil loci were specific to eosinophils or had effect on more blood parameters.

[0326] Data on white blood cell differential counts, platelet counts, and several red blood cell parameters were analyzed for the set of Icelanders having blood eosinophil counts. IgE measurements were also available for a smaller subset of individuals. FIG. 5 shows an overview of the association of the SNPs identified through the blood eosinophil count genome-wide scan with all these blood measurements. The results of the analysis is shown in Table 9.

TABLE-US-00009 TABLE 9 Eosinophils Neutrophils Lymphocytes Monocytes Basophiles WBC SNP Eff..sup.a P Eff..sup.a P Eff..sup.a P Eff..sup.a P Eff..sup.a P Eff..sup.a P rs1420101 9.0 .sup. 6.4 .times. 10.sup.-14 1.2 0.27 -0.2 0.83 0.7 0.53 0.2 0.88 1.8 0.13 rs12619285 6.5 8.5 .times. 10.sup.-7 0.3 0.81 0.2 0.90 -0.2 0.89 0.0 1.0 0.2 0.85 rs4857855 9.9 .sup. 7.3 .times. 10.sup.-11 -3.4 0.016 2.3 0.11 1.2 0.41 14.5 1.8 .times. 10.sup.-25 -1.3 0.38 rs4143832 12.3 .sup. 1.9 .times. 10.sup.-14 0.4 0.79 1.7 0.24 -0.1 0.95 2.2 0.13 2.2 0.15 rs2269426 6.4 3.5 .times. 10.sup.-7 3.3 4.4 .times. 10.sup.-3 2.9 1.2 .times. 10.sup.-2 3.3 3.8 .times. 10.sup.-3 3.8 7.3 .times. 10.sup.-4 .sup. 4.3 3.6 .times. 10.sup.-4 rs3184504 9.9 .sup. 2.1 .times. 10.sup.-16 2.9 8.3 .times. 10.sup.-3 6.3 1.1 .times. 10.sup.-8 3.7 7.3 .times. 10.sup.-4 1.3 0.24 5.3 6.3 .times. 10.sup.-6 rs2416257 8.1 1.3 .times. 10.sup.-6 0.6 0.69 2.5 0.10 2.4 0.12 1.4 0.37 2.3 0.16 rs9494145 8.0 5 .times. 10.sup.-9 4.7 1.7 .times. 10.sup.-4 4.3 6.4 .times. 10.sup.-4 4.8 1.3 .times. 10.sup.-4 3.5 5.3 .times. 10.sup.-3 .sup. 6.8 3.8 .times. 10.sup.-7 rs748065 5.3 3.2 .times. 10.sup.-5 1.3 0.27 3.0 9.8 .times. 10.sup.-3 0.7 0.55 2.8 1.5 .times. 10.sup.-2 .sup. 2.1 0.097 rs3939286 5.9 1.2 .times. 10.sup.-5 -1.9 0.13 0.9 0.46 -0.6 0.63 1.6 0.21 -0.5 0.73 Platelets RBC Hematocrit Hemoglobin IgE SNP Eff..sup.a P Eff..sup.a P Eff..sup.a P Eff..sup.a P Eff..sup.a P rs1420101 1.6 0.18 -1.4 0.17 0.0 0.99 0.0 0.99 13.2 3.2 .times. 10.sup.-5 rs12619285 2.2 8.8 .times. 10.sup.-2 0.9 0.43 0.8 0.47 0.5 0.66 -5.0 0.16 rs4857855 1.6 0.29 -1.2 0.38 -2.5 5.1 .times. 10.sup.-2 -2.3 0.066 0.6 0.87 rs4143832 0.8 0.60 0.0 0.97 1.8 0.18 1.8 0.18 0.9 0.82 rs2269426 3.7 2.5 .times. 10.sup.-3 -1.5 0.17 -2.1 4.8 .times. 10.sup.-2 -1.7 0.10 7.0 3.3 .times. 10.sup.-2 rs3184504 7.9 .sup. 3.0 .times. 10.sup.-11 3.9 1.7 .times. 10.sup.-4 3.4 9.5 .times. 10.sup.-4 3.7 2.2 .times. 10.sup.-4 1.5 0.65 rs2416257 2.5 0.13 -0.2 0.89 -1.4 0.32 -1.3 0.34 1.2 0.79 rs9494145 -7.6 1.4 .times. 10.sup.-8 14.9 .sup. 1.0 .times. 10.sup.-36 5.2 7.6 .times. 10.sup.-6 3.6 1.3 .times. 10.sup.-3 1.4 0.71 rs748065 0.9 0.46 -0.3 0.79 -0.5 0.62 -0.1 0.91 1.5 0.66 rs3939286 -1.5 0.25 -1.2 0.3 -0.9 0.43 -1.3 0.24 3.7 0.31 .sup.aEffects are given in percentage of standard units.

[0327] The sequence variants associating with eosinophil counts clustered into two groups; those having a broad effect (association P<0.01) on the majority of the blood cell types and those with effect limited to one or two blood parameters (FIG. 5).

Example 3

[0328] Given the role of eosinophils in the pathogenesis of asthma, the fifteen SNPs from the ten loci identified through the blood eosinophil count scan were tested for association with asthma and with its sub-phenotypes of atopic and non-atopic asthma in seven case control sample sets of European origin and one sample set of East Asian origin. Even though the association of SNPs at only six of the ten loci reached our threshold for genome-wide significance for association with eosinophil counts, the association of all fifteen SNPs with asthma was assessed, since some of the five remaining suggestive loci may yet be true positives.

[0329] The association of SNPs identified in the eosinophil genome-wide scan with asthma in seven sample sets (European and one East Asian sample set) are shown below in Tables 10 and 11.

TABLE-US-00010 TABLE 10 Asthma Atopic Asthma Non-atopic asthma Control Freq OR Freq OR Freq OR Sample Freq (N) (N) (95% CI) P (N) (95% CI) P (N) (95% CI) P rs1420101 A - in the IL1RL1 gene Iceland 40.6 43.9 1.15 8.7 10.sup.-5 42.8 1.10 0.059 44.9 1.19 0.0015 (38,349) (2,227) (1.07, 1.23) (881) (1.00, 1.21) (690) (1.07, 1.32) Australia I.sup.a 36.8 42.8 1.28 0.0041 43.6 1.33 0.0018 39.1 1.10 0.53 (511) (607) (1.08, 1.52) (499) (1.11, 1.59) (101) (0.81, 1.51) Australia II.sup.a 38.2 40.8 1.11 0.069 41.8 1.16 0.029 38.8 1.03 0.75 (1,184) (1,195) (0.99, 1.25) (713) (1.02, 1.33) (447) (0.88, 1.20) Germany I.sup.a 35.5 37.0 1.07 0.57 37.6 1.10 0.45 31.0 0.82 0.54 (499) (227) (0.85, 1.35) (206) (0.86, 1.39) (21) (0.42, 1.58) Germany II.sup.a 32.9 34.9 1.09 0.29 35.5 1.13 0.20 33.1 1.02 0.89 (157.sup.b) .sup. (548) (0.93, 1.29) (409) (0.94, 1.35) (139) (0.79, 1.31) UK.sup.a 38.1 43.5 1.25 0.085 48.4 1.53 0.037 31.0 0.73 0.36 (218) (283) (0.97, 1.61) (64) (1.03, 2.27) (21) (0.37, 1.43) Denmark.sup.a 37.1 40.3 1.14 0.039 41.0 1.18 0.029 39.0 1.08 0.38 (1,320) (842) (1.01, 1.29) (518) (1.02, 1.36) (323) (0.91, 1.29) Netherlands.sup.a 35.6 39.7 1.19 0.021 42.5 1.31 0.022 40.4 1.22 0.44 (1,967) (455) (1.03, 1.39) (162) (1.04, 1.65) (31) (0.73, 2.05) Italy.sup.a 38.1 43.7 1.26 0.025 44.0 1.26 0.035 39.9 1.06 0.84 (280.sup.b) .sup. (308) (1.03, 1.55) (282) (1.02, 1.56) (22) (0.58, 1.96) Korea.sup.a 34.0 38.8 1.23 0.013 39.6 1.27 0.0068 37.6 1.17 0.11 (405) (1,304) (1.04, 1.45) (797) (1.07, 1.52) (489) (0.97, 1.43) Combined -- -- 1.16 5.5 10.sup.-12 -- 1.18 5.9 10.sup.-10 -- 1.11 0.0017 (44,890) (7,996) (1.11, 1.21) (4531) (1.12, 1.24) (2284) (1.04, 1.19) rs3939286 A - near the IL33 gene Iceland 24.8 27.1 1.13 0.0023 26.9 1.11 0.048 25.6 1.04 0.48 (38,336) (2,231) (1.04, 1.21) (883) (1.00, 1.24) (694) (0.92, 1.18) Australia I 24.7 28.9 1.24 0.024 28.9 1.24 0.030 28.3 1.21 0.27 (507) (634) (1.03, 1.49) (521) (1.02, 1.51) (106) (0.86, 1.68) Australia II 25.2 25.9 1.04 0.60 26.4 1.06 0.41 25.3 1.00 0.98 (1,187) (1,199) (0.91, 1.18) (715) (0.92, 1.24) (449) (0.84, 1.20) Germany I 25.0 31.4 1.37 0.015 32.6 1.45 0.0051 17.6 0.64 0.31 (502) (204) (1.06, 1.77) (187) (1.12, 1.89) (17) (0.27, 1.51) Germany II 20.4 21.6 1.08 0.41 20.9 1.02 0.83 24.0 1.22 0.14 (157.sup.b) .sup. (548) (0.90, 1.30) (409) (0.83, 1.25) (139) (0.94, 1.58) UK 26.2 28.1 1.10 0.53 32.0 1.33 0.22 23.8 0.88 0.74 (166) (286) (0.81, 1.50) (64) (0.85, 2.08) (21) (0.42, 1.85) Denmark 25.0 26.3 1.07 0.33 27.0 1.11 0.23 25.4 1.02 0.83 (1,342) (858) (0.93, 1.23) (521) (0.94, 1.30) (336) (0.84, 1.24) Netherlands 25.7 28.8 1.17 0.067 32.6 1.36 0.013 20.9 0.77 0.39 (1,953) (435) (0.99, 1.39) (167) (1.07, 1.74) (31) (0.42, 1.41) Italy 29.4 32.4 1.15 0.22 32.3 1.14 0.28 34.0 1.23 0.54 (280.sup.b) .sup. (309) (0.92, 1.44) (283) (0.90, 1.43) (22) (0.63, 2.37) Korea 3.5 3.2 0.92 0.66 3.4 0.95 0.81 3.0 0.85 0.48 (567) (1,463) (0.63, 1.34) (879) (0.63, 1.43) (566) (0.53, 1.35) Combined -- -- 1.12 5.3 10.sup.-6 -- 1.14 2.2 10.sup.-5 -- 1.04 0.33 (44,997) (8,167) (1.07, 1.17) (4629) (1.07, 1.21) (2381) (0.96, 1.12) rs2416257 G - near the WDR36 gene Iceland 85.2 86.4 1.10 0.050 87.0 1.17 0.029 85.5 1.03 0.74 (38,229) (2,225) (1.00, 1.21) (880) (1.02, 1.34) (691) (0.88, 1.19) Australia I 87.5 87.9 1.04 0.79 88.2 1.07 0.65 85.6 0.85 0.46 (452) (627) (0.80, 1.34) (516) (0.81, 1.40) (104) (0.55, 1.32) Australia II 86.1 87.2 1.10 0.26 87.6 1.14 0.18 86.8 1.06 0.59 (1,188) (1,193) (0.93, 1.30) (711) (0.94, 1.39) (448) (0.85, 1.33) Germany I 81.2 88.8 1.84 0.00014 89.3 1.94 7.2 10.sup.-5 83.3 1.16 0.72 (497) (241) (1.34, 2.51) (220) (1.40, 2.69) (21) (0.51, 2.62) Germany II 84.8 84.4 0.97 0.80 85.1 1.03 0.81 82.6 0.86 0.33 (157.sup.b) .sup. (548) (0.78, 1.21) (409) (0.81, 1.31) (139) (0.63, 1.17) UK 81.1 86.9 1.55 0.011 89.1 1.90 0.028 85.7 1.40 0.45 (222) (287) (1.11, 2.18) (64) (1.07, 3.37) (21) (0.59, 3.33) Denmark 86.4 88.1 1.17 0.095 88.3 1.20 0.11 87.8 1.14 0.31 (1,324) (857) (0.97, 1.40) (523) (0.96, 1.48) (333) (0.88, 1.47) Netherlands 85.5 84.3 0.91 0.37 85.1 0.98 0.88 71.1 0.43 0.0075 (1,920) (455) (0.74, 1.12) (165) (0.71, 1.34) (28) (0.23, 0.80) Italy 85.4 89.6 1.46 0.015 90.1 1.52 0.011 83.5 0.84 0.69 (280.sup.b) .sup. (310) (1.08, 1.99) (284) (1.10, 2.09) (22) (0.37, 1.91) Korea 94.4 95.4 1.23 0.18 95.5 1.26 0.17 95.2 1.18 0.36 (603) (1,506) (0.91, 1.66) (905) (0.90, 1.75) (583) (0.82, 1.70) Combined -- -- 1.13 0.00012 -- 1.20 4.2 10.sup.-6 -- 1.01 0.78 (44,872) (8,249) (1.06, 1.20) (4677) (1.11, 1.29) (2390) (0.92, 1.12) rs9494145 T - near the MYB gene Iceland 75.7 75.7 1.00 0.91 76.5 1.05 0.42 75.0 0.96 0.55 (38,365) (2,226) (0.93, 1.09) (883) (0.94, 1.17) (691) (0.85, 1.09) Australia I 76.4 77.3 1.05 0.61 77.8 1.08 0.45 76.2 0.99 0.95 (509) (631) (0.87, 1.28) (521) (0.88, 1.33) (103) (0.69, 1.41) Australia II 75.3 77.8 1.15 0.037 77.3 1.12 0.16 78.9 1.23 0.029 (1,186) (1,197) (1.01, 1.32) (715) (0.96, 1.30) (447) (1.02, 1.47) Germany I 78.3 83.0 1.36 0.027 83.1 1.36 0.030 82.6 1.32 0.47 (525) (259) (1.04, 1.77) (236) (1.03, 1.79) (23) (0.62, 2.80) Germany II 73.7 77.8 1.25 0.023 78.7 1.33 0.0086 75.0 1.08 0.61 (157.sup.b) .sup. (546) (1.03, 1.51) (407) (1.07, 1.64) (139) (0.81, 1.43) UK 76.8 76.7 0.99 0.97 76.2 0.97 0.89 73.8 0.85 0.66 (203) (286) (0.74, 1.34) (61) (0.60, 1.56) (21) (0.41, 1.77) Denmark 76.1 79.0 1.18 0.030 78.6 1.15 0.11 79.5 1.22 0.063 (1,327) (858) (1.02, 1.36) (525) (0.97, 1.36) (332) (0.99, 1.49) Netherlands 78.4 77.1 0.93 0.39 77.3 0.94 0.66 90.1 2.47 0.018 (1,941) (458) (0.78, 1.10) (166) (0.72, 1.23) (30) (1.17, 5.25) Italy 74.9 75.3 1.02 0.85 75.8 1.05 0.72 69.0 0.74 0.37 (280.sup.b) .sup. (308) (0.80, 1.30) (282) (0.81, 1.35) (22) (0.39, 1.42) Korea 68.3 70.9 1.13 0.12 72.2 1.20 0.031 69.0 1.04 0.71 (525) (1381) (0.97, 1.32) (830) (1.02, 1.43) (533) (0.86, 1.24) Combined -- -- 1.07 0.0037 -- 1.12 0.00024 -- 1.06 0.10 (45,018) (8,150) (1.02, 1.13) (4626) (1.05, 1.19) (2341) (0.99, 1.15) .sup.aBecause of assay quality issues, the reported results are based on the T allele of rs950880 (R.sup.2 = 0.96 in the CEU HapMap samples). .sup.bAn estimate of the number of un-transmitted parental alleles used as control alleles.

TABLE-US-00011 TABLE 11 Asthma Atopic Asthma Non-atopic asthma Control Freq OR Freq OR Freq Sample Freq (N) (N) (95% CI) P (N) (95% CI) P (N) OR (95% CI) P rs12619285 G Iceland 73.8 73.3 0.97 0.54 73.7 1.00 0.97 73.9 1.01 0.94 (38412) (1747) (0.89, 1.06) (691) (0.87, 1.14) (548) (0.87, 1.17) Germany II 72.2 73.3 1.06 0.54 73.6 1.09 0.48 73.7 1.13 0.56 (204x) (415) (0.89, 1.26) (415) (0.86, 1.38) (415) (0.76, 1.67) Korea 35.4 36.6 1.05 0.50 36.6 1.05 0.52 36.8 1.06 0.50 (567) (1472) (0.91, 1.21) (882) (0.90, 1.23) (572) (0.89, 1.26) Combined -- -- 1.00 0.95 -- 1.03 0.53 -- 1.04 0.52 (--) (--) (0.94, 1.07) (--) (0.94, 1.13) (--) (0.93, 1.15) rs4857855 T Iceland 81.7 82.5 1.06 0.26 81.5 0.99 0.86 82.7 1.07 0.46 (38361) (1749) (0.96, 1.17) (692) (0.85, 1.15) (548) (0.90, 1.27) Australia 84.5 82.4 0.86 0.18 82.0 0.84 0.13 83.7 0.94 0.77 (503) (625) (0.69, 1.07) (517) (0.66, 1.06) (101) (0.62, 1.42) Germany I 83.0 82.2 0.95 0.69 82.6 0.98 0.86 78.0 0.73 0.38 (535) (264) (0.72, 1.25) (239) (0.73, 1.30) (25) (0.36, 1.47) Germany II 85.0 85.4 1.03 0.77 85.0 1.05 0.70 87.6 0.86 0.53 (204x) (415) (0.84, 1.26) (415) (0.81, 1.37) (415) (0.54, 1.36) UK 85.0 83.9 0.92 0.64 89.1 1.44 0.23 97.6 7.25 0.0072 (223) (289) (0.66, 1.30) (64) (0.79, 2.61) (21) (1.71, 30.72) Denmark 81.7 81.4 0.98 0.79 80.6 0.93 0.46 82.4 1.05 0.66 (1329) (842) (0.84, 1.15) (511) (0.78, 1.12) (330) (0.84, 1.31) Korea 82.3 82.3 1.00 0.99 83.5 1.09 0.61 88.0 1.57 0.24 (1938) (445) (0.83, 1.20) (154) (0.79, 1.48) (29) (0.74, 3.33) Netherlands 68.2 70.8 1.13 0.11 70.0 1.09 0.32 72.1 1.20 0.047 (565) (1444) (0.97, 1.31) (871) (0.92, 1.28) (555) (1.00, 1.44) Combined -- -- 1.02 0.44 -- 1.00 0.94 -- 1.09 0.082 (--) (--) (0.96, 1.09) (--) (0.92, 1.08) (--) (0.99, 1.21) rs4143832 C Iceland 15.5 16.1 1.05 0.30 15.7 1.02 0.83 17.3 1.14 0.097 (38387) (2286) (0.96, 1.15) (887) (0.88, 1.17) (703) (0.98, 1.34) Australia 16.7 16.7 1.00 0.99 17.7 1.08 0.53 12.3 0.70 0.10 (504) (635) (0.80, 1.25) (522) (0.86, 1.35) (106) (0.46, 1.07) Germany I 18.3 21.9 1.26 0.080 22.9 1.33 0.034 13.0 0.67 0.30 (517) (285) (0.97, 1.62) (258) (1.02, 1.72) (27) (0.31, 1.44) Germany II 23.0 23.1 1.01 0.95 24.4 0.99 0.94 20.8 1.17 0.49 (204x) (415) (0.84, 1.21) (415) (0.78, 1.26) (415) (0.75, 1.83) UK 14.7 17.5 1.23 0.23 20.2 1.46 0.15 14.3 0.97 0.94 (221) (286) (0.88, 1.72) (62) (0.87, 2.47) (21) (0.39, 2.38) Denmark 19.9 19.4 0.97 0.68 18.9 0.94 0.47 20.3 1.02 0.83 (1327) (859) (0.83, 1.13) (525) (0.78, 1.12) (333) (0.83, 1.27) Korea 16.3 16.8 1.04 0.70 16.9 1.05 0.66 16.8 1.04 0.74 (581) (1471) (0.86, 1.24) (888) (0.86, 1.28) (566) (0.83, 1.29) Combined -- -- 1.04 0.19 -- 1.04 0.30 -- 1.05 0.34 (--) (--) (0.98, 1.11) (--) (0.96, 1.13) (--) (0.95, 1.16) rs9494145 T Iceland 75.7 75.6 1.00 0.98 76.5 1.05 0.48 75.0 0.96 0.61 (38,365) (2,117) (0.92, 1.08) (880) (0.92, 1.18) (686) (0.84, 1.11) Australia 76.4 77.3 1.05 0.61 77.8 1.08 0.45 76.2 0.99 0.95 (509) (631) (0.87, 1.28) (521) (0.88, 1.33) (103) (0.69, 1.41) Germany I 78.3 83.0 1.36 0.027 83.1 1.36 0.030 82.6 1.32 0.47 (525) (259) (1.04, 1.77) (236) (1.03, 1.79) (23) (0.62, 2.80) Germany II 73.6 77.7 1.25 0.021 79.4 1.31 0.030 76.2 1.28 0.28 (204.sup.b) .sup. (415) (1.04, 1.51) (319) (1.03, 1.68) (96) (0.82, 2.01) UK 76.6 78.1 1.09 0.58 76.2 0.98 0.93 73.8 0.86 0.69 (203) (263) (0.80, 1.49) (61) (0.61, 1.58) (21) (0.41, 1.79) Denmark 76.1 79.0 1.18 0.030 78.6 1.15 0.11 79.5 1.22 0.063 (1,327) (858) (1.02, 1.36) (525) (0.97, 1.36) (332) (0.99, 1.49) Netherlands 78.4 77.1 0.93 0.39 77.3 0.94 0.66 90.1 2.47 0.018 (1,941) (458) (0.78, 1.10) (166) (0.72, 1.23) (30) (1.17, 5.25) Korea 68.3 70.9 1.13 0.12 72.2 1.20 0.031 69.0 1.04 0.71 (525) (1,381) (0.97, 1.32) (830) (1.02, 1.43) (533) (0.86, 1.24) Combined 1.06 0.020 -- 1.12 0.0013 -- 1.05 0.25 (1.01, 1.12) (--) (1.05, 1.20) (--) (0.96, 1.15) rs3184504 T Iceland 38.2 37.6 0.98 0.48 36.7 0.94 0.26 39.4 1.05 0.40 (38314) (2273) (0.91, 1.04) (881) (0.84, 1.05) (699) (0.93, 1.19) Australia 49.7 45.6 0.85 0.050 45.7 0.85 0.070 45.7 0.85 0.29 (511) (622) (0.72, 1.00) (513) (0.72, 1.01) (104) (0.63, 1.15) Germany I 49.4 50.9 1.06 0.58 51.0 1.06 0.57 50.0 1.02 0.93 (533) (282) (0.86, 1.30) (254) (0.86, 1.31) (28) (0.60, 1.75) Germany II 46.3 46.4 1.01 0.94 46.1 0.94 0.57 53.0 0.87 0.46 (204x) (415) (0.86, 1.18) (415) (0.76, 1.16) (415) (0.61, 1.25) UK 47.0 44.0 0.89 0.35 50.8 1.16 0.45 50.0 1.13 0.71 (217) (285) (0.69, 1.14) (62) (0.78, 1.74) (21) (0.60, 2.13) Denmark 51.2 51.3 1.00 0.98 49.1 0.92 0.26 54.6 1.14 0.13 (1204) (850) (0.89, 1.13) (520) (0.79, 1.06) (329) (0.96, 1.36) Combined 0.97 0.26 0.94 0.069 1.04 0.33 (0.92, 1.02) (0.88, 1.00) (0.96, 1.14) rs2269426 T Iceland 32.3 34.5 1.11 0.0058 32.7 1.02 0.74 36.9 1.23 0.0012 (38394) (2222) (1.03, 1.19) (877) (0.91, 1.14) (693) (1.08, 1.39) Australia 36.0 34.8 0.95 0.54 36.0 1.00 0.99 30.3 0.77 0.11 (501) (625) (0.80, 1.13) (514) (0.84, 1.19) (104) (0.56, 1.06) Germany I 42.1 46.2 1.18 0.12 46.8 1.21 0.084 40.4 0.93 0.81 (532) (263) (0.96, 1.46) (237) (0.97, 1.51) (26) (0.53, 1.64) Germany II 42.8 40.5 0.91 0.25 38.0 0.91 0.40 36.1 0.63 0.019 (204x) (415) (0.77, 1.07) (415) (0.73, 1.14) (415) (0.43, 0.93) UK 34.7 38.1 1.16 0.27 35.2 1.02 0.92 31.0 0.85 0.63 (215) (289) (0.89, 1.50) (64) (0.68, 1.55) (21) (0.43, 1.67) Denmark 38.0 33.8 0.83 0.024 35.4 0.89 0.26 31.6 0.75 0.011 (1172) (470) (0.71, 0.98) (260) (0.73, 1.09) (209) (0.60, 0.94) Korea 31.0 30.1 0.96 0.59 30.4 0.98 0.77 29.4 0.93 0.40 (578) (1475) (0.83, 1.11) (890) (0.83, 1.15) (567) (0.78, 1.11) Combined -- -- 1.03 0.27 -- 1.00 0.99 -- 0.99 0.86 (--) (--) (0.98, 1.08) (--) (0.93, 1.07) (--) (0.91, 1.08) rs748065 A Iceland 69.4 69.7 1.02 0.67 70.0 1.03 0.60 68.2 0.95 0.40 (38154) (2221) (0.94, 1.09) (880) (0.92, 1.16) (690) (0.83, 1.08) Australia 69.5 70.3 1.04 0.68 70.5 1.05 0.63 70.6 1.05 0.75 (521) (631) (0.87, 1.24) (523) (0.87, 1.26) (102) (0.76, 1.46) Germany I 69.3 75.0 1.33 0.017 75.2 1.34 0.016 73.1 1.20 0.56 (526) (270) (1.05, 1.68) (244) (1.06, 1.71) (26) (0.65, 2.23) Germany II 64.1 65.1 1.04 0.62 63.9 1.17 0.19 61.2 1.03 0.87 (204x) (415) (0.88, 1.24) (415) (0.93, 1.47) (415) (0.69, 1.54) UK 75.8 71.9 0.82 0.16 72.7 0.85 0.47 66.7 0.64 0.20 (223) (290) (0.62, 1.08) (64) (0.54, 1.33) (21) (0.32, 1.28) Denmark 69.6 70.2 1.03 0.69 70.4 1.04 0.63 70.0 1.02 0.83 (1328) (861) (0.90, 1.17) (525) (0.89, 1.21) (335) (0.85, 1.23) Korea 43.8 42.6 0.95 0.49 42.8 0.96 0.59 42.4 0.94 0.50 (578) (1451) (0.83, 1.09) (878) (0.83, 1.12) (556) (0.80, 1.11) Combined -- -- 1.02 0.46 -- 1.05 0.17 -- 0.97 0.46 (--) (--) (0.97, 1.07) (--) (0.98, 1.12) (--) (0.89, 1.05)

[0330] SNPs belonging to three loci, rs1420101 on 2q11 in the IL1RL1 (interleukin 1 receptor-like 1) gene, rs3939286 on 9p24 near the IL33 (interleukin 33) gene, and rs2416257 on 5q22 in the WDR36 (WD repeat domain 36) gene, satisfied our criteria for significance after accounting for the testing of fifteen SNPs in three phenotypes (P<0.05/15/3=0.0011). The asthma risk alleles for all three SNPs were the alleles correlating (although only significantly for IL1RL1) with increased blood eosinophil counts (Tables 4 and 7). For the IL33 and WDR36 SNPs, the observed association with atopic asthma was stronger than that for non-atopic asthma (Table 7). The A allele of rs1420101 on 2q11 also correlated positively with serum IgE (P=2.110.sup.-5), but with none of the other measured blood parameters (FIG. 5). The other two SNPs did not associate with any of the other blood parameters measured. Our genotyping assay for rs1420101 did not give good results on amplified DNA and we therefore used rs950880 as a surrogate for most of the non-Icelandic samples (R.sup.2=0.96 in the CEU HapMap samples).

[0331] SNP (rs9494145) on 6q23 is located between the HBS1L (HBS1-like (S. cerevisiae)) and MYB (v-myb myeloblastosis viral oncogene homolog (avian)) genes. The T allele of this marker showed genome-wide significant association to blood eosinophil counts (Table 6). The same allele showed association to asthma, in particular atopic asthma. The MYB gene acts as a nuclear transcription factor that is implicated in proliferation, survival and differentiation of hematopoietic stem and progenitor cells (Martinez-Moczygemba et al., J Allergy Clin Immunol 112: 653-65 (2003). The HBS1L gene belongs to the GTP-binding elongation factor family and could as such be involved in regulating variety of cellular processes.

[0332] The SNP rs1420101 on 2q11 is located in a linkage disequilibrium (LD) block that contains four genes: IL1RL1, IL18R1 (interleukin 18 receptor 1), IL18RAP (interleukin 18 receptor associated protein) and SLC9A4 (solute carrier family 9). SNPs in this LD block have previously been associated with Crohn's disease (rs917997) (Zhernakova et al., Am J Hum Genet 82: 1202-1210 (2008)) and celiac disease (rs917997 and rs13015714) (Hunt et al., Nat Genet 40: 395-402 (2008)) as well as atopic dermatitis (AD) (rs6543116) (Shimizu et al., Hum Mol Genet 14: 2919-2927 (2005)) and asthma (rs1974675) (Zhu et al., Eur J Hum Genet 16: 1083-1090 (2008)). The Crohn's and celiac diseases variants are not correlated with rs1420101, and these variants did not associate with either eosinophil counts or asthma in our samples (data not shown). The AD variant is in weak LD with rs1420101, and rs1420101 did not associate with AD in the previous study (Shimizu et al., 2005, supra). The rs1974675 SNP was recently shown to associate with asthma in a candidate gene study (Zhu et al., 2008, supra). This SNP is in LD with rs1420101 (D'=1, R.sup.2=0.27, in the European HapMap data (Nature 437: 1299-1320 (2005)) but has not been typed in our asthma or eosinophil sample sets. However, another SNP (rs10206753) that is on the Illumina chip and is in much stronger LD with rs1974675 than rs1420101 (D'=1, R.sup.2=0.96, in the European HapMap data (Nature 437: 1299-1320 (2005)) shows weaker association than rs1420101 with eosinophil counts (P=0.00031 vs. P=6.81010.sup.-6) and asthma (P=0.00057 vs. P=0.00013) in the Icelandic discovery sample set. Furthermore, its association with asthma and eosinophil counts could be accounted for by rs1420101 (P>0.18 for both eosinophil counts and asthma), while the association of rs1420101 could not be accounted for by rs1974675 (P=0.0022 for eosinophil counts and P=0.025 for asthma).

[0333] The SNP rs1420101 is located in the IL1RL1 (also known as ST2) gene. The protein encoded by this gene has three splice variants, a soluble secreted form of ST2, a transmembrane form ST2L, and ST2V, localized at the plasma membrane, but lacking a substantial intracellular portion, suggesting that it may be a decoy for ligands of ST2L (Tago et al., Biochem Biophys Res Commun 285: 1377-1383 (2001)). Rs1420101 is in an exon that is alternatively spliced and only present in the ST2V form. A second variant associating with asthma, rs3939286, located on 9p24, 32 kb proximal to the coding start of the IL33 gene, that encodes a cytokine belonging to the IL1 super family, and is the natural ligand for the IL1RL1/ST2 receptor (Schmitz et al., Immunity 23: 479-490 (2005)). IL33 can also function as a chromatin associated nuclear factor with transcriptional regulatory properties (Carriere et al., Proc Natl Acad Sci USA 104: 282-287 (2007)). Signalling through the IL1RL1/ST2-IL33 complex plays an important role in eosinophil maturation, survival and activation, both by direct effects on eosinophils and indirectly through recruitment and regulation of Th 2 cell effector functions (Cherry et al., J Allergy Clin Immunol 121: 1484-1490 (2008)). Furthermore, the effect of IL1RL1/ST2-IL33 on eosinophil effector functions is as potent as that of IL5 (Schmitz et al., 2005, supra). These functions are consistent with a major contribution of IL1RL1/ST2-IL33 signaling in eosinophil-mediated inflammation (Cherry et al., 2008, supra), such as the one encountered in asthma. Although the 2q11 variant is located within the IL1RL1 gene, the other genes within the same LD block--IL18R1, IL18RAP and SLC9A4-can not be excluded as genes involved. IL18R1 and IL18RAP encode the receptor for the IL-18 cytokine that has been implicated in inflammatory diseases, including asthma.

[0334] The SNP rs2416257, the most strongly associated SNP at the 5q22 locus, is located in an LD block that contains the WDR36 and TSLP (thymic stromal lymphopoietin isoform 1) genes. WDR36 encodes a T-cell activation protein with a minimum of eight WD40 repeats that is highly co-regulated with interleukin 2 (IL2) (Mao et al., Genomics 83: 989-999 (2004)). TSLP encodes an interleukin 7-like cytokine that is expressed within the thymus and peripheral tissues and regulates dendritic cell-mediated central tolerance, peripheral T cell homeostasis, and inflammatory Th2 response. TSLP is a key initiator of allergic airway inflammation in mice (Zhou et al., Nat Immunol 6: 1047-1053 (2005)) and its expression is increased in the airways of patients with asthma and correlates with expression of Th2-attracting chemokines and disease severity (Ying et al., J Immunol. 174: 8183-8190 (2005)).

Example 4

[0335] This example demonstrates the association of the SNPs identified through the blood eosinophil counts with myocardial infarction.

[0336] The association of the 15 SNPs identified through the blood eosinophil counts scan were examined in chronic obstructive pulmonary disease (COPD) and myocardial infarction (MI) using Icelandic genome-wide scan data (Helgadottir et al., Science 316: 1491 (2007)).

[0337] None of the SNPs associated significantly with COPD (N cases=765, N controls=39,376). As shown in Table 12, two SNPs: the T allele of rs3184504 and the G allele of rs653178, both located in the SH2B3 gene on chromosome 12, associated significantly with MI (P<0.002).

TABLE-US-00012 TABLE 12 SNP/Allele Chr N Freq OR (95% CI) P value rs1420101 A 2 2,627/33,714 41.2/40.8 1.02 (0.96, 1.08) 0.55 rs12619285 A 2 2,626/33,722 73.7/73.6 1.01 (0.94, 1.08) 0.88 rs4857855 C 3 2,627/33,721 81.7/81.7 1.00 (0.93, 1.09) 0.90 rs7635061 A 3 2,627/33,722 74.2/74.0 1.01 (0.94, 1.08) 0.87 rs2416257 G 5 2,619/33,568 85.1/85.2 0.99 (0.91, 1.08) 0.78 rs184941 G 5 2,626/33,723 74.1/74.3 0.99 (0.92, 1.06) 0.77 rs4143832 A 5 2,623/33,703 15.3/15.5 0.99 (0.91, 1.08) 0.80 rs2079103 T 5 2,625/33,727 21.0/21.3 0.98 (0.91, 1.05) 0.54 rs2269426 T 6 2,625/33,701 32.9/32.3 1.03 (0.96, 1.09) 0.44 rs9494145 T 6 2,627/33,710 75.6/75.7 1.00 (0.93, 1.07) 0.91 rs748065 A 8 2,594/33,486 69.0/69.5 0.98 (0.92, 1.05) 0.51 rs1412426 T 9 2,626/33,713 33.5/33.0 1.03 (0.96, 1.09) 0.42 rs3939286 A 9 2,626/33,720 25.3/24.8 1.03 (0.96, 1.10) 0.44 rs3184504 T 12 2,625/33,625 40.4/38.0 1.11 (1.04, 1.18) 0.0012 rs653178 G 12 2,627/33,724 40.7/38.3 1.10 (1.04, 1.18) 0.0016

[0338] The association of both SNPs with MI was subsequently analyzed in six sample sets of European ancestry: an Icelandic replication set, three American replication sets (Duke, Emory, UPenn), New Zealand, and Verona. The results are shown in Tables 13 and 14.

TABLE-US-00013 TABLE 13 rs653178 G allele Freq Sample Set N (case/ctrl) (case/ctrl) OR (95% CI) P value Iceland 2,627/33,724 40.7/38.3 1.10 (1.04, 1.18) 0.0016 discovery Iceland 343/3709 42.6/38.6 1.18 (1.01, 1.38) 0.041 replication US--Duke 1210/733 49.9/44.2 1.26 (1.10, 1.43) 0.00054 US--Emory 603/1234 48.8/46.5 1.10 (0.95, 1.26) 0.19 US--UPenn 676/463 54.4/53.8 1.03 (0.87, 1.21) 0.76 New Zealand 567/511 48.1/45.5 1.11 (0.94, 1.31) 0.23 Verona 643/388 52.7/50.0 1.12 (0.93, 1.33) 0.23 Combined 1.14 (1.07, 1.21) 5.0 10.sup.-5 replication Combined 1.12 (1.07, 1.17) 4.5 10.sup.-7

TABLE-US-00014 TABLE 14 rs3184504--T allele Freq Sample Set N (case/ctrl) (case/ctrl) OR (95% CI) P value Iceland 2,625/33,625 40.4/38.0 1.11 (1.04, 1.18) 0.0012 discovery Iceland 343/3,700 42.0/38.2 1.17 (1.00, 1.37) 0.053 replication US, Durham 1,209/730 49.7/43.9 1.26 (1.11, 1.44) 0.00045 US, Atlanta 588/1,216 49.7/46.7 1.13 (0.98, 1.29) 0.096 US, 681/462 53.7/54.1 0.99 (0.83, 1.17) 0.86 Philadelphia New 558/501 49.2/45.2 1.17 (0.99, 1.39) 0.067 Zealand Verona 646/387 53.1/49.5 1.16 (0.97, 1.38) 0.11 Combined 1.15 (1.08, 1.23) 1.1 10.sup.-5 replication Combined 1.13 (1.08, 1.18) 8.6 10.sup.-8

[0339] Similar to the blood eosinophil data (Table 1), the association with MI was slightly stronger for rs3184504 (combined OR=1.13, 95% CI: 1.08-1.18, P=8.610.sup.-8) than rs653178 (combined OR=1.12, 95% CI: 1.07-1.17, P=4.510.sup.-7). The Welcome Trust Case Control Consortium (WTCCC) has published imputed genotype counts for rs3184504 on 1,477 coronary artery disease (CAD) cases and 2,932 controls which yield an OR of 1.10 and a P value of 0.025 for the T allele (Nature 447: 661-678 (2007)).

[0340] rs3184504 is a non-synonymous SNP in exon 3 of the SH2B3 (SH2B adaptor protein 3) gene (also known as LNK), leading to a R262 W amino acid change. This variant has previously been shown to associate with type I diabetes (Todd et al., Nat Genet 39: 857-864 (2007)) and celiac disease (Hunt et al., 2008, supra). In addition to associating with eosinophil counts and increased risk of MI, the T allele of rs3184504 associates with increase of the following blood parameters: Neutrophil counts (P=0.0083), lymphocyte counts (P=1.110.sup.-8), monocyte counts (P=0.00073), white blood cell counts (P=6.310.sup.-6), platelet counts (P=3.010.sup.-11), red blood cell counts (P=0.00017), hematocrit (P=0.00095) and hemoglobin (P=0.00022) (FIG. 1). A trend towards risk for hypertension was observed for rs3184504, but no association was observed between rs3184504 and other traditional risk factors for MI, such as HDL (P=0.63, N=8,269), LDL (P=0.70, N=5,615), type 2 diabetes (P=0.85, N diabetics=1,521, N controls=34,754) and smoking initiation (P=0.46, N smokers=10,521, N never smokers=5,954 (Thorgeirsson et al., Nature 452: 638-642 (2008)). SH2B3 is a member of the APS family of adaptor proteins acting as a broad inhibitor of growth factor and cytokine signaling pathways. Lnk deficient mice exhibit profound perturbation of hematopoiesis with increased numbers of megakaryocytes, B lymphoid and erythroid progenitor cells and well as hematopoietic stem cells (Velazquez et al., J Exp Med 195: 1599-1611 (2002)). The association of rs3184504 T with increased counts for all major human blood cell types further supports an important role for SH2B3 in regulating human hematopoietic progenitor and stem cell numbers. Furthermore, the observed effect of rs3184504-T is consistent with reduced activity of the SH2B3 protein. The SH2B3 gene is expressed in human vascular endothelial cells, where it modulates the proinflammatory action of TNF.alpha., counteracting the TNF.alpha.-induced increase in leukocyte adhesion to endothelial cells, but promoting endothelial NO-synthase (eNOS) activity (Fitau et al., J Biol Chem 281, 20148-59 (2006)). The amino acid substitution by rs3184504 could contribute to the progression of plaques in coronary arteries leading to MI through reduced anti-inflammatory activity of SH2B3. Alternatively, rs3184504 could confer risk of MI through increased platelet or white blood cell counts since increased counts of these cells have been shown to correlate with CAD (Danesh et al., Jama 279: 1477-1482 (1998)).

[0341] The sequence variants at the remaining loci did not associate significantly with risk of the three diseases tested. Briefly, a SNP (rs4857855) located near the GATA2 (encoding GATA binding protein 2) gene on 3q21, associates significantly with blood eosinophil counts (Table 1), but even more significantly with blood basophil counts (effect=14.5, 95% CI: 11.8-17.2, P=1.810.sup.-25). GATA2 is a transcription factor that acts as an important regulator of hematopoiesis (Hirasawa et al., J Exp Med 195: 1379-1386 (2002)), affecting mainly the differentiation of cells of the eosinophil, basophil, and mast cell lineages (Iwasaki et al., Genes Dev 20: 3010-3021 (2006)). A SNP (rs4143832) located near the IL5 (interleukin 5 (colony-stimulating factor, eosinophil)) gene on 5q31 showed association that was restricted to blood eosinophil counts. IL5 is a growth and differentiation factor for B cells and controls the production, activation and localization of eosinophils (Martinez-Moczygemba et al., J Allergy Clin Immunol 112: 653-665; quiz 666 (2003)). A SNP (rs12619285) located near the IKZF2 (encoding IKAROS family zinc finger 2 (Helios)) gene on 2q13 showed association specific to blood eosinophil counts. This gene has not previously been linked to eosinophil biology but is a well know and important regulator of lymphocyte development and differentiation through transcriptional regulation.sup.25. Finally a SNP (rs9494145) on 6q23, between the HBS1L (HBS1-like (S. cerevisiae)) and MYB (v-myb myeloblastosis viral oncogene homolog (avian)) genes, showed suggestive association with most of the blood parameters measured (FIG. 5). Variants at this locus, highly correlated with rs9494145, have previously been shown to associate with fetal hemoglobin levels in adults (Thein et al., Proc Natl Acad Sci USA 104: 11346-11351 (2007)) and subsequently platelet, monocyte counts, and white blood cell counts (Menzel et al., Blood 110: 3624-3626 (2007)). The MYB gene acts as a nuclear transcription factor that is implicated in proliferation, survival and differentiation of hematopoietic stem and progenitor cells (Martinez-Moczygemba et al., J Allergy Clin Immunol 112: 653-665; quiz 666 (2003)). The HBS1L gene belongs to the GTP-binding elongation factor family and could as such be involved in regulating variety of cellular processes.

[0342] The results in Table 1 suggest some population heterogeneity with respect to association with eosinophil counts. First, the association of the SNP at IL5 in non-Icelandic Europeans is weaker (P=0.00055) than would have been expected based on the Icelandic data. Second, the relationship with the SNP at MYB is in the inverse direction of what would be expected (P=0.00053). The association with both SNPs is most likely true; at IL5 because of the overall level of significance (P=6.010.sup.-11) and the very strong candidacy of the IL5 locus, and at MYB because of the replicating association with hemoglobin levels and many other blood parameters. This heterogeneity is either due to the different criteria for sample inclusion or inherent differences in auto-immune stress between the different populations. In particular, the Icelandic population is known to have low exposure to parasites.

[0343] In summary, several sequence variants associating with blood eosinophil counts were discovered by performing a genome-wide association scan of a large number of individuals. Following a previous approach to smoking and lung cancer and peripheral artery disease (Thorgeirsson et al., Nature 452: 638-642 (2008)) and pigmentation and skin cancers (Gudbjartsson et al., Nat Genet 40: 886-891 (2008)) and that of others with uric acid and gout (Vitart et al., Nat Genet 40: 437-442 (2008)), the association of the variants showing the strongest suggestive association with eosinophil counts with disease was then assessed, and identified three asthma and one MI susceptibility loci. Most of the sequence variants associating with blood eosinophil counts do not associate with asthma, suggesting that the effect of the variants associating with asthma is not through eosinophil counts, but rather that both the effect on eosinophil counts and disease risk are a consequence of effects on other parts of the auto-immune system. Association data on other blood parameters show that the loci identified cluster into a group with a rather specific effect on only one or two cell types and a group of loci with a global effect on most or all cell types.

Example 5

[0344] A nominally significant association of rs3184504-T with hypertension was observed in Iceland (OR=1.05, P=0.015, N hypertensives=9,586, N controls=27,687) and a similar trend was also observed in the imputed WTCCC data (OR=1.07, P=0.11, N hypertensives=1,948, N controls=2,932). No association was found with systolic blood pressure in Iceland (P=0.27, N=13,579), while the T allele of rs3184504 correlated with higher systolic blood pressure in the 1958 birth cohort (P=0.0037, N=5,918).

[0345] All references, including publications, patent applications, and patents, cited herein are hereby incorporated by reference to the same extent as if each reference were individually and specifically indicated to be incorporated by reference and were set forth in its entirety herein.

[0346] The use of the terms "a" and an and the and similar referents in the context of describing the invention (especially in the context of the following claims) are to be construed to cover both the singular and the plural, unless otherwise indicated herein or clearly contradicted by context. The terms "comprising," "having," "including," and "containing" are to be construed as open-ended terms (i.e., meaning "including, but not limited to,") unless otherwise noted. Recitation of ranges of values herein are merely intended to serve as a shorthand method of referring individually to each separate value falling within the range, unless otherwise indicated herein, and each separate value is incorporated into the specification as if it were individually recited herein. All methods described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context. The use of any and all examples, or exemplary language (e.g., "such as") provided herein, is intended merely to better illuminate the invention and does not pose a limitation on the scope of the invention unless otherwise claimed. No language in the specification should be construed as indicating any non-claimed element as essential to the practice of the invention.

[0347] Preferred embodiments of this invention are described herein, including the best mode known to the inventors for carrying out the invention. Variations of those preferred embodiments may become apparent to those of ordinary skill in the art upon reading the foregoing description. This invention includes all modifications and equivalents of the subject matter recited in the claims appended hereto as permitted by applicable law. Moreover, any combination of the above-described elements in all possible variations thereof is encompassed by the invention unless otherwise indicated herein or otherwise clearly contradicted by context.

Sequence CWU 1

1

6811599DNAHomo sapiens 1ttggtgaaaa aagtaggtaa cctattagtg cctgtctata aaagagtgag gacttagatt 60tctaaatgca tactaacaag tatatttata aagacagatt ttattacctg attgtataaa 120gcagaagtct cctttaacag attaaaagaa gaggtgggtg gaatatgcta acaaacaaag 180gtccatgtgt gaatcggggg atattcagga cttaactaga cttcagcaga ctcatttagg 240atcttaaaca ctgtcccaag tccaaaattc acatttaagc tgagagcagc taggactttr 300ctatctatct atggtttaag ttgtcttcca ctcggcttgt aaagcctaga gtgtcactgt 360ttctgcccac agatagctgt caatcttggc ccataaggag atggaaccat aggaaatgtt 420tcatctccac tcccagcact tctttccata taaaaagatt tccactagca cagcagtcct 480gacatctctg ttctcaggag aagagggaat catttaatgt tattgagtcc ctttacctcc 540tcattctctt gagagctatg tgcatagaga aagcatactt tctgctctgc tatttcaga 5992599DNAHomo sapiens 2taagatgcaa aaatatgtgg tctaatatca tagttttaga gaattaagaa ggtaaattca 60tcctagagtt tggatcaaac aaataatatt tagaaggaat atatcataag gtgataactt 120tgtatgtcgg tatatatgta agtgtgggtg tgtgtaaatc attaaatttc catatatata 180ccatataatt ttctacctga aatgttgtga gttaaatcaa aaaatgtaaa ttattcctac 240atatcattaa tattataaat tcaggaccat agttatttat atatttattt ttaaaattcy 300ggttgaagca tttggtgaaa cagttccaga attgagtttt ttattctttc tatatgtgga 360gcatatggta aaattattcc tatttctaat atgagtttgg tattttattg ttaaactcta 420gaaaacaacc accttttagc caagaacctt tgccctctaa gacacactca attgtatttt 480acttttgcta ccaacattta ggggttagtt tactttgtgt tatcatattc caccaatatt 540caaaagattt atcacttggc aagagttact gatgacactc catgagtagg aaacctcaa 5993599DNAHomo sapiens 3caaggaatgg taactggtgg ggttgtcttt ttgctgaatg aagagaagaa aagaagaatt 60ccaagtctgt ttcccaggca caggaaggac caggaagcaa ggaaacttcc aattttcaag 120tccactgagc agaatacaag aacagggtcc aaaacaaaga gttctccgtt gagaaccggc 180aagatggagc aagcaagtcc tgcaggcagg ctgggcctgg agaggcgcca agaggccaca 240gcactcttgg gaggaggttt ttctggactc ttgaggagct gagactttta tattccaacs 300ctgcctttaa tttgaggttt gcctcctccc tccatttgca gaagagtaat ccgaagctaa 360atcattcata acatgagaat gctgatctgt gtccagccct tgtgaaggga aaagaaaaca 420aaacttcaca aacataatta gtagaactac ctataaaacc taatgttaaa agagaaatta 480gctttcatgg agagaaagtg tgatggcatg acacagaaat taagtgcact gaatttagat 540ttgaaaagag tttgattcaa ttcatgtccc tgcttcccag tagtccgtga ccttgggca 5994599DNAHomo sapiens 4ctgcagcctt gatctcctag gctttagtga ttttcccatc tcagcctgct gagtagctgg 60gaccacaggc acacaccact aaccctttat ttatttattt atttatttat ttattttgta 120gagacggtgt cttgctatgt tgtccaggct ggtctagaat tcctgggctc aagggatcca 180cctgccttgg cctcccaaag taaaagtatc tttattttcc tatttaaaat gctctttcag 240cttctgattg aatttagaat gaaatctgaa cactcttctt tggactacat gatgctatam 300gtcctggtga cagtctccca ctgtctcttt ctgcagtgga ttaagcaccc aattgccaag 360tttatctttt tcaacaggta gtgaaattat gtttgtgttg ttgttttgtt ttgttttgtt 420tgttttgaga cagggtctca ctctgtcacc caggctggag tgcagtggta cactcactgt 480ctcttgtcag tgcccctcac tgtgctcagc cagactggtg cacccactgg cctttaaaca 540ccctaaactc ctatctgctt caggggcctt gggtttgctc ttccctctaa attcagtgc 5995599DNAHomo sapiens 5gcttcttaca aatgagacct ctaaatgttg aagtgctcca gagcttgatc tctagccata 60ctttttccta gccctgtgaa tttgtatacc accagatgcc aattcctcct aaatgcgtct 120cctcagcctt gacccaaatc caacagcata tttgacattt ttacttgtat aaaaatgttt 180taacatacca aaaacaagac tcatgataat tccccatctt gtcaaaatct gtgctaagat 240tcccccatcc ccaattttcc ttacttgctc aagttgaaaa tccaggggtc tttgatttty 300ccacttttat ctgtcagatt tgatccttct gtaactctat ttctcctact acctccttgg 360tctaaaccag caagttttcc cccatctcta gcctggatta ctgaaatgac caccaatctg 420agcttctagc tctcactttt tttcctgtct gcagtggatt aagcacccaa ttgccaagtt 480tatcttttga acaggcagtg aaattatgtt tgtgttgttt tgttttgttt cgagacaggg 540tctcactctg tcacccaggc tggagtgcaa tggtgcaatc atggctcact gcagccttg 5996599DNAHomo sapiens 6ggagcaggag tagacaggga aagccttcag atcatgacat gtgtgaaagg tgaggggcag 60gaaggaggat taagtaggaa aagcctgtga ttagggtgca gctctgagaa agtctcagcc 120agcccaacca gggagctctg tcataaagac tgcccacagg ggagcctgtg agttggaatg 180gctgggaatc aggagcgttg tagtgattgt gctcagtcct tacctaggag ttatgtcagg 240aaaagcctgg ccttagctta aatgctgtgg tggatcccaa aggtgctata gctggaggcy 300gtcacctaat tgcattcctg gcagctgatc agcaaggcct ttgttagaga gaggctcagg 360tagcacactc cctggccacc ataggagggt tatacatttt ctatatgagg gctctataat 420gttggtatgc tcatggaatc aaggaggtat aatggagcta acaccatcac ttaatttaca 480aaaattagca aagaacttaa ttttgtttta ttgatacttc taataccaac atttcttgac 540agaagaaaaa tatttcccaa tattcattta aatggtgcca acaaaagtat ttttaaaca 5997599DNAHomo sapiens 7atttgtgtgc gtgtgtgagc acacatcttt ccttctttga actaagttgc accaggcaat 60tccttacagc tgattcccca actttgtcct gaataaagcc ggtcagacat gggagggaca 120aagaaagcta aaaaccaatg agtcatctgg gaatagatgt tctctttact accctttatc 180agaatgagga aatgatgcct tccccccaaa tagaggcagt aaacagtgaa gatgactgaa 240tgcttttctt ctgtctagcc ttcatagcac ctcagcttac caaggaaaat ggagcttctr 300tctcatagtg agtgtgttct ctcttcccta cctaaagagg ctgcaacatg attagggctc 360gtctagaagt acaaaggaag atctcaggga cacaaggaag ccagaaatag ttgaggtcaa 420tcaggccagg ttagggttgg tgctgccata ctatattcct ctttgacctg ggcatgtttt 480ccaggaggat ctatttccct tggaaagctc tttaagtaac actatgtgaa atttataata 540aatcctctca ccccaagatg actgcttcag atatgagggg gagtagtgag gaatgatgg 5998599DNAHomo sapiens 8tttgacatct gctaagctat tagacaccag tttttaaaga aataaaccat tccctgtaca 60tagaattaga aaaaaaaaat gtaagaaatc attttttaat tcagaaacaa gagccagaac 120caacattcct actacagatt aatactatct atacataatc ctgaaataca cctaactaaa 180gagctactga ctagcatgcc tgccactgtc ctctgctatc tgctctgttc cagtgctctc 240ttgggtaacc caagtctgtt tcaaaggctt tcacactgtg gtaccagaga taagaattgw 300ctcaggcttt tgcagacaat aactactgac cacagtaagg tggatttccc accccagaag 360tggtatcaac tgaaaaggga actctctttg atcttatcca gcgtcttcat gccattttaa 420attactccac tgtggcatct tatttcccaa ttccacagtc atcttacttg tttattcatt 480tgaacacctg aagttacatt atttgaaatg atttcctacc tggaaaaatg aaacagggat 540ttaaagcact catcctgtgg tgtacaaagg atagatagag agacttcctc atgtgcaaa 5999599DNAHomo sapiens 9acatgtaagc atacaatttg tgacttgaaa atgtacagaa gcagaagttt acaaattgtg 60aaaaaaacag aataacattt ggcatttgga tgaaatgttt tccctctgcg tactttcaaa 120cccattaacc ccttatttta ttttaacagc attcttatga tataggtgaa tttggtcttt 180agaattactc atattttact gtgggaaatg agcttattac ctgcccaagg aatgcagata 240tggaatttat attcagatta aaattctatc accatgatgt tctttccaag aaaaattgtk 300gcctgtcaaa aagagaagca ggatggactt caaccgaaag ttggaaataa cgctgaaaag 360aagaaagaat aataataatt ttttaaaaga tggcttggca gatgaagata atgcagcatt 420ataatccctt ggagttggtt tggtcaacat ttgtaatctc accccttgct taagccttgg 480taaaataaca ttttatctta tggtattttt tacatacatt acttgctttc aaaattattc 540tacaccacat agctcaaaaa ggagctttaa aatatctaaa ttgccatgga tgatacaaa 59910599DNAHomo sapiens 10gaattcttgt tttggttgta aggagacttg taaatggctt tcttcatatt cttctacttt 60aaaaatagta ggggatgggt gtaaaagtgg ctaaatgaga acattaaaga aagggctctt 120aaaggtattt ggacctgcca ggcaaactct gtaaagttgc agtagagttg ttttcaaggt 180aatagtcagc gtccttctct gaaagctgat ttaacttggc tagatgatag gcatctcttt 240gggtaagtta aagggtctca agcaataaag tatgttttat cttggttaag ctgataatty 300gtcctactta agcaagtaat gcaaatttcc ttgcaaagct ctgtgctcat tagctcataa 360ttagggcaat aaatctggaa tcacaaaaca gatcagtgaa aacatcatag tactgtaaat 420gtgggagtga ggttatcttc tcctgtagga atcagtagag agtttgcaaa aatctattcg 480gattctgact gtgactctac atgtgattat cataaattta actactagga agaagagaag 540gaaaggaagg ctgagggcct tcctttaaca gtccaggtga caaccaaaat tttaaagac 59911599DNAHomo sapiens 11gtattgactc ccaagctttt gctatggaat gtcttaagac atcatgtcat ttatctgatt 60ccttgtctgt aaaaatctag gaggtggact taaataatca ccaaggtttc catctggccc 120taacattccc tatttcgtga tggtgtgttc ctcatctctc tcacatatgc accttgacat 180ttgcctttat gttaaaaatt aagtgttggg ttcatatctt caattcccac tctttttaca 240tggcttaaat ctgagctatt tgtcctcact tctaaatgaa tgctcccttt agagaaacty 300tgacaccaac tgttctgtgt tttgaataac ttagagagaa taagattcca ggtcagtaat 360gagcaaccca tgactcagtt ttgcaatctt cccatatttt ccatgtgatg aagaacctat 420tttcaggata caattagaaa attgctctgg attattacaa accttaacat attggtgact 480aagaagtgcc tgcaattttt ttcactgaca ctaaatggat aatctaggtt gaatgaatat 540atccactctc acaaaagccc aaataaagct atccccatgt tgaatttttt aaggtggcc 59912599DNAHomo sapiens 12taagccttga ggaatgggaa aaaaaggaaa tggaatggct ttccccattc agagatagca 60cctccccacc atgctcataa ctcagacagc actgcacttt aaaggtaagg ggagggggca 120catacaagga acaggtaaga aaaataagac tttcctgcaa ctctaccatt cttcttagaa 180cttctctgac catgaatatc tttctttctc tttctagttc tctgcctatc catcaaggac 240aagcttatcc ccaaattttc ccaaggttcc cagcccatag cctcctctta gtcccataay 300cttctggcac ctgtctctct acccacttgt atggatgtta atcccaagcc atactctaac 360tcttctgctg ctttcatgtt ttgccattat atttcttgtg tttatatttt gtttcctaat 420tagattgtaa gtaacttgaa gtgcctggaa gatgtctttt cttttaaaat tagttgacca 480aagaaagaaa aggaaaaggt aatgcagaaa aagaaagcaa acactgtaac tcagaagaat 540ttgccccaac aactcaaata tcagcttcac tccaaagcta caccccaaaa ctaagcagg 59913599DNAHomo sapiens 13atatccccca ctctctgcac tcccttctct gcctgcttgg aagtcagaca gtgaggaaac 60tctatgtatg gtatgtggtc catatattaa tattttagcc actcaggcta cagagcagca 120tggggaagag tggagcatag atctacattc catagcaact taattcagca tccctttaga 180actttctaag taagcagtca gcgtgggttg gttaaactgc acaaacctgt aacgaatgag 240tgatttcaag tacattttta aaacagtacc ataattttct gctgagcttc cgaaggcaas 300gcatcagaga agctgtcaac actaatgctg tctatagaaa atggaaaatt aacaaagcaa 360gaagaaatga tcaatttgaa cttggtttgg ctgtgtaaaa cttctaattt cagtcatata 420tattagttgc ttaccattta tgcctaatta ccatgtagca caataatgtg tatcattaaa 480catgtgccaa attaacttta caatattaac tttacaatgt taacttagca ttattagctt 540agttcaagtt tggacagttt ttgtaggttt tgactcaggt acatgcttct ccctctttt 59914599DNAHomo sapiens 14atgttgctca tgaccttagt tgttcaagta gagtttgttg aatacacaag atgattagca 60gaggaggaag cattatagga ttaatatagt tcataaacct ttaggggttt atagcctcta 120tgagaaataa accagggcat ttttagccca aatgattaga taccaaaaca aatttgtaaa 180aataacaggt gggaagaaag catcttgaaa caatatattt tttcttatta tcttggccac 240tgtatagatt gtctggtacc ttgagtctta tcttctctgt ggtcctgagg cagtccctay 300atataattag ctctggacct ggcctgacct ccaggagcaa tgtctagaat gtgttcatta 360cagtgcctgg cacataggaa gagtgaattg agtgtttgtt aaatgaatac agataagaat 420aatcaaaatg ctcattggtg agattgatta aaataaatta tatatccatg cactgggata 480ctatgcaact gtgaaaatta tgtagttaac tatttaataa catggaaaga caatgacaga 540ttattaatta gaaaaaagtt ataaatcata tgagtagaat gattccatat gtgaataaa 59915599DNAHomo sapiens 15taccatgggt gagcgagctt tgccttagct aacttccttt actaaccctc tcaccccaca 60ctaattccat tccctacact attgtcatag taagtggttt ctattatata gactttaccc 120tgtgccctga attttctatg agacaaaata caactcccat tagcttggcg ttcaagatct 180tttagaccta tccttttcag ctttttcagg ctttcctttt tatatactcc accagacata 240cgtctcttga aacaacaaaa taatggtatt ttccacctcc catttctccc tttcctgtcw 300ctcctcactc cacaagagtc tgccttaagc tccagaccct cccctgaatg taccctcaaa 360tatgggcacc cacgacctat atactcctaa atccattggg catttttcac ttagtagcaa 420tgaacacgtt gagcacttcc tttcctccta attctttggc ttctccttta ttaatctcct 480tttctggcga tttttcttct atttatagtt caatattctg cccccaggac tctttcctga 540gcagttttct tttcttcaat tctctttacg ttctacaaac tctctttggg aaatccaca 59916599DNAHomo sapiens 16tttttcaggc tttccttttt atatactcca ccagacatac gtctcttgaa acaacaaaat 60aatggtattt tccacctccc atttctccct ttcctgtctc tcctcactcc acaagagtct 120gccttaagct ccagaccctc ccctgaatgt accctcaaat atgggcaccc acgacctata 180tactcctaaa tccattgggc atttttcact tagtagcaat gaacacgttg agcacttcct 240ttcctcctaa ttctttggct tctcctttat taatctcctt ttctggcgat ttttcttctm 300tttatagttc aatattctgc ccccaggact ctttcctgag cagttttctt ttcttcaatt 360ctctttacgt tctacaaact ctctttggga aatccacact actctttacg gttccaatta 420ctatctatgt gcaagtgcca aataatcctc tatttctaag cttacctctt tcctgaaccc 480tatatataca attgctcata agactttcca acttaagggt cttgtgcatg atataaacat 540agtgttttca gaagggaatt cctcatcctc caaccctccc tagtcaacct ctttttcat 59917599DNAHomo sapiens 17aaatccattg ggcatttttc acttagtagc aatgaacacg ttgagcactt cctttcctcc 60taattctttg gcttctcctt tattaatctc cttttctggc gatttttctt ctatttatag 120ttcaatattc tgcccccagg actctttcct gagcagtttt cttttcttca attctcttta 180cgttctacaa actctctttg ggaaatccac actactcttt acggttccaa ttactatcta 240tgtgcaagtg ccaaataatc ctctatttct aagcttacct ctttcctgaa ccctatatay 300acaattgctc ataagacttt ccaacttaag ggtcttgtgc atgatataaa catagtgttt 360tcagaaggga attcctcatc ctccaaccct ccctagtcaa cctctttttc attaaagttg 420cacacctgta taaatgacac cactcaccca atttcttcag tgagaattga ggagatatat 480ttgacctctc ccactatttt tgacccctac aactagttac catatcttgt tgattatatc 540tcacaaatat ctctaaaatt catcacataa tgacaatcca ttgcagccat cttacccca 59918599DNAHomo sapiens 18ttacgttcta caaactctct ttgggaaatc cacactactc tttacggttc caattactat 60ctatgtgcaa gtgccaaata atcctctatt tctaagctta cctctttcct gaaccctata 120tatacaattg ctcataagac tttccaactt aagggtcttg tgcatgatat aaacatagtg 180ttttcagaag ggaattcctc atcctccaac cctccctagt caacctcttt ttcattaaag 240ttgcacacct gtataaatga caccactcac ccaatttctt cagtgagaat tgaggagatr 300tatttgacct ctcccactat ttttgacccc tacaactagt taccatatct tgttgattat 360atctcacaaa tatctctaaa attcatcaca taatgacaat ccattgcagc catcttaccc 420cagactgcca tcatctctta cctaaattaa ttaatcactt ggctccaatg ttgtcccaca 480tgaacccatc ctgctctagg ctcatctatt tttcttcaaa tctgataatt taacccccta 540acttaaaacc cttcaagata aagttcaatt atcttgaact ttgattatca cttttaagg 59919599DNAHomo sapiens 19ttcattaaag ttgcacacct gtataaatga caccactcac ccaatttctt cagtgagaat 60tgaggagata tatttgacct ctcccactat ttttgacccc tacaactagt taccatatct 120tgttgattat atctcacaaa tatctctaaa attcatcaca taatgacaat ccattgcagc 180catcttaccc cagactgcca tcatctctta cctaaattaa ttaatcactt ggctccaatg 240ttgtcccaca tgaacccatc ctgctctagg ctcatctatt tttcttcaaa tctgataatw 300taacccccta acttaaaacc cttcaagata aagttcaatt atcttgaact ttgattatca 360cttttaaggc tttctaagat ctagttctgg cccccactac cagcccagat gatgtaccat 420gtgtactttc acactatatg gtccagcttg tatctggacc tcttgtgtct ctctcttttt 480tttttttttc tttttgagat ggcgtcttgc tctgttgccc aggctggagt gcagtggcgc 540aatctcggct cactgcaagc tccgcctccc aggttcacgc cattctcctg cttcagcct 59920599DNAHomo sapiens 20agaaatcatt tgtattttta tatcttgttt tcaatattta aatgacacat gctatttcca 60ttcccaaatt aattgataaa tacatgaata aataaaatag ctgtgccata tagttatcct 120tgatatcact ctagatgagg aaactgaggc tggaaagatt aaacagctta agtaatatta 180acaaagcaaa taactcttgg gacctccttg ctctgtgtat gtcaaagctc atgctctctt 240tcaactccat tacatctctt tgaatcagat agtaagatga aacctcttct aggaagtaar 300gacttcctgg ccccaatcaa ttctttttac ttgccacctg cttgtgaata ttaatattgc 360tttcgctgga ttttaaaaag tagactccta ggtaaacagc aaacaagaga ggcagaggcc 420agaatgctca gaaaaaagga tacaaactgg cgcaataagg attatatggt ctgaagcaga 480ggtatgtgga agctgaggtg ggaaagtgat ggtaaagcaa accagaccca aggatattgg 540tttatcttat ggcaatactt aacccatgga atgagaacat ttgtatgaat tatccatgc 59921599DNAHomo sapiens 21ttcatcttta gttttatcca aattagattg gctaattttc atctgagttc ttcagacatc 60atatcttgtg ccgaatatct tagctctcaa attcctaact tcctatttta gaaaattcag 120accaaaatca attctctagt tttccaaaca cttgttactg attttctttc catacactta 180ataatgtaga ggttcaacaa cttagtgcgt tgcatcacat attaattgtc ttctatatca 240tctcattgaa atgcatccag gacatactat tattcttccc acctctattc attttttttk 300gttttatttg gcaaggaaat aaggccctat agctacttta ttcaaaatca ttatctctgc 360aacataattt cttttgttta tttttcttat tttagtattt ataaattctc ttactgttcc 420acaagttcag tggggcagtg gtctaacttt tccaactatc aaatcacttt aacacaaact 480tactttctcc tacaactgaa ttggctatct ttactgaaaa attataaata tgaaatcata 540taaaaacata aaaaataata atttaaatga tattttataa ttatatatta taataattt 59922599DNAHomo sapiens 22aataatgtag aggttcaaca acttagtgcg ttgcatcaca tattaattgt cttctatatc 60atctcattga aatgcatcca ggacatacta ttattcttcc cacctctatt catttttttt 120ggttttattt ggcaaggaaa taaggcccta tagctacttt attcaaaatc attatctctg 180caacataatt tcttttgttt atttttctta ttttagtatt tataaattct cttactgttc 240cacaagttca gtggggcagt ggtctaactt ttccaactat caaatcactt taacacaaay 300ttactttctc ctacaactga attggctatc tttactgaaa aattataaat atgaaatcat 360ataaaaacat aaaaaataat aatttaaatg atattttata attatatatt ataataattt 420ataatataaa taatttatat accttatttc aatgtacata taaatctttg tatttgaatc 480cctggtccat cacttgttaa ctccacagct ttaggcaagg ccgttaaacc ctttgaagtc 540tcttgttatt ccatctagaa aatatgggtg acaatggaat ttccatcata gctttgaag 59923599DNAHomo sapiens 23ctttaggcaa ggccgttaaa ccctttgaag tctcttgtta ttccatctag aaaatatggg 60tgacaatgga atttccatca tagctttgaa gatgaaataa gaaaaacatg gaaattatta 120tagtgactac cacataacaa ggcaataaaa ggtagctgtg gttattgtta taaagcagga 180gtatttatat agttcaatgt aattattagg atagaccata gatctgcttt tgagcccttg 240aaatgtagcc caaattgaga tatgctataa atgtaaaata cacactgggt ttcaaagacy 300tagtataaaa aacaaagaag gtaaagtata tcactaataa gtttttacat gcatacatgt 360tgaaatgata ttttagatat attggattaa attaaatatg ttaaaattaa ttttgtatgt 420tttaaatatt tttaaaatgg ccactagaaa aattaattac acatgcagct tgtatttgtg 480gtacacatta tatttctact gtacagtact gctataaata ataataatta taaacccatg 540agtgggttta gttttactta gaaatcttgt cataaatttt ctctcatgtg aaatgttgt 59924599DNAHomo sapiens 24gttcaatgta attattagga tagaccatag atctgctttt gagcccttga aatgtagccc 60aaattgagat atgctataaa tgtaaaatac acactgggtt tcaaagacct agtataaaaa 120acaaagaagg taaagtatat cactaataag tttttacatg catacatgtt gaaatgatat 180tttagatata ttggattaaa ttaaatatgt taaaattaat tttgtatgtt ttaaatattt 240ttaaaatggc cactagaaaa attaattaca catgcagctt gtatttgtgg tacacattay 300atttctactg tacagtactg ctataaataa taataattat aaacccatga gtgggtttag 360ttttacttag aaatcttgtc ataaattttc tctcatgtga aatgttgtca cccataatga 420actcttataa attcttatat agacatgtaa aatattttga aatattttat tataggatat 480atagaaaata ttctcaggat tattaatttg taatgacata ttaatatatt ataatttgat 540ataaaggctc tttttatatc atatttgcaa gatgtcttcc ttatgtaggc tgtgaaaaa 59925599DNAHomo sapiens 25tatatagaca tgtaaaatat tttgaaatat tttattatag gatatataga aaatattctc 60aggattatta atttgtaatg acatattaat atattataat ttgatataaa ggctcttttt 120atatcatatt tgcaagatgt cttccttatg taggctgtga

aaaaaataaa gatttacttg 180ggtatcatat atttatacac ccagttaatt tacaaatgtg agggtaactg aagacctgta 240tgataataga tgggaaaact tagttaattt tgctaaaagg aatgcagttt accagaagay 300cagtaataga ttgtggttaa aaagtggtcc tagagaagcc tgtgtaagta aaagacattg 360tctaaaagct gtgtggggat atagggttgt tctataactg tacatcctgc ctctcagtgt 420gaccttgagc atcatggact atgacgaaac cctagtttct agccatgtga ccaactagtt 480gttaagaaaa caggcttgta taaataaatt cacccaaaga ttcatgctga aggcctcaga 540ttccatttct ataaattgag atgctctctg ataacctcca gctcaaaagg agatgataa 59926599DNAHomo sapiens 26ctgaagacct gtatgataat agatgggaaa acttagttaa ttttgctaaa aggaatgcag 60tttaccagaa gatcagtaat agattgtggt taaaaagtgg tcctagagaa gcctgtgtaa 120gtaaaagaca ttgtctaaaa gctgtgtggg gatatagggt tgttctataa ctgtacatcc 180tgcctctcag tgtgaccttg agcatcatgg actatgacga aaccctagtt tctagccatg 240tgaccaacta gttgttaaga aaacaggctt gtataaataa attcacccaa agattcatgs 300tgaaggcctc agattccatt tctataaatt gagatgctct ctgataacct ccagctcaaa 360aggagatgat aatacatgac acattcaaac aggtaagtgg aaatatatcc ctacttttta 420catttgtata tgccacattt ataaagagaa taactttaag tattacttta ccctatacct 480cacaaaaaaa aaaacaagaa actgtctgaa catttatgac agaaaagaca tatgcctaga 540ttcctcagac ccctgctgag gtattcaggg actctctgga caaagctgtg ctcagcgga 59927599DNAHomo sapiens 27tagggttgtt ctataactgt acatcctgcc tctcagtgtg accttgagca tcatggacta 60tgacgaaacc ctagtttcta gccatgtgac caactagttg ttaagaaaac aggcttgtat 120aaataaattc acccaaagat tcatgctgaa ggcctcagat tccatttcta taaattgaga 180tgctctctga taacctccag ctcaaaagga gatgataata catgacacat tcaaacaggt 240aagtggaaat atatccctac tttttacatt tgtatatgcc acatttataa agagaataay 300tttaagtatt actttaccct atacctcaca aaaaaaaaaa caagaaactg tctgaacatt 360tatgacagaa aagacatatg cctagattcc tcagacccct gctgaggtat tcagggactc 420tctggacaaa gctgtgctca gcggaagttt gggctctctg gttctggtct ttgtttctgt 480ttctaataca cattcatact aaaaggaact gaaaattgag gtacagttct cttaaaatta 540ctctgtaccc tgatttccac ctaagtcttt agttgtcttt ctgaaaactt cccagtaca 59928599DNAHomo sapiens 28tcacccaaag attcatgctg aaggcctcag attccatttc tataaattga gatgctctct 60gataacctcc agctcaaaag gagatgataa tacatgacac attcaaacag gtaagtggaa 120atatatccct actttttaca tttgtatatg ccacatttat aaagagaata actttaagta 180ttactttacc ctatacctca caaaaaaaaa aacaagaaac tgtctgaaca tttatgacag 240aaaagacata tgcctagatt cctcagaccc ctgctgaggt attcagggac tctctggacm 300aagctgtgct cagcggaagt ttgggctctc tggttctggt ctttgtttct gtttctaata 360cacattcata ctaaaaggaa ctgaaaattg aggtacagtt ctcttaaaat tactctgtac 420cctgatttcc acctaagtct ttagttgtct ttctgaaaac ttcccagtac aattttagaa 480tctctcttca atacccctgt ttccatgagt ctattcttta ccacccaaac cttctcctac 540taggagtccc aggtaacttg tacctctggt ttttttgttt gtttttgttg tttttttta 59929599DNAHomo sapiens 29tcaaaaggag atgataatac atgacacatt caaacaggta agtggaaata tatccctact 60ttttacattt gtatatgcca catttataaa gagaataact ttaagtatta ctttacccta 120tacctcacaa aaaaaaaaac aagaaactgt ctgaacattt atgacagaaa agacatatgc 180ctagattcct cagacccctg ctgaggtatt cagggactct ctggacaaag ctgtgctcag 240cggaagtttg ggctctctgg ttctggtctt tgtttctgtt tctaatacac attcatactm 300aaaggaactg aaaattgagg tacagttctc ttaaaattac tctgtaccct gatttccacc 360taagtcttta gttgtctttc tgaaaacttc ccagtacaat tttagaatct ctcttcaata 420cccctgtttc catgagtcta ttctttacca cccaaacctt ctcctactag gagtcccagg 480taacttgtac ctctggtttt tttgtttgtt tttgttgttt tttttagaga tggggtacca 540ctctgtctcc cagactggag tgcagtggca caatcttagc tcactgtagc ctcaaattc 59930599DNAHomo sapiens 30ataactttaa gtattacttt accctatacc tcacaaaaaa aaaaacaaga aactgtctga 60acatttatga cagaaaagac atatgcctag attcctcaga cccctgctga ggtattcagg 120gactctctgg acaaagctgt gctcagcgga agtttgggct ctctggttct ggtctttgtt 180tctgtttcta atacacattc atactaaaag gaactgaaaa ttgaggtaca gttctcttaa 240aattactctg taccctgatt tccacctaag tctttagttg tctttctgaa aacttcccar 300tacaatttta gaatctctct tcaatacccc tgtttccatg agtctattct ttaccaccca 360aaccttctcc tactaggagt cccaggtaac ttgtacctct ggtttttttg tttgtttttg 420ttgttttttt tagagatggg gtaccactct gtctcccaga ctggagtgca gtggcacaat 480cttagctcac tgtagcctca aattcccaga tgaaagcgat tctcctgcct cagcctctgc 540tgtagctagg actacaggtg agcaccactg cacctggcta atttttaaaa ttgtttgta 59931599DNAHomo sapiens 31tgcaactcta ctcaactctc caatttcatc tcttgttccc atcttacact caagccatac 60tgaacactca attctctgaa tggaaccatt catatttatt cactctctgt ttctgtcatt 120gtttctcttg gactcttctt gtctttccct gtctgcccca ctgtctcttc caggactttg 180tagatgtctt tcctctgctt agaacatgtt ttccattttc ccatttcatc tttccctctt 240tgtgaaattt acttttgttt atctttttga actcagctta gttgtgactt ctaccaggay 300atatttttct tagtctcagg ctgaattagg ttccccaccc atttgtttcc acagtatatt 360tctttcatat ttatggtaat aattaccgtg ttttatgatg cctaattatt tgtttgcttc 420ctcactgtaa gatttttgta tccttgaata cagggattgt gtcttattca atattatgtg 480ctaagcacct agaccagcac attggaagta ccgaataaat gaatgaactt cctacagtat 540ttagtcaagg ggcttgcatg caataaatac tctacttcct aaattttaga taatttttt 59932599DNAHomo sapiens 32ttcatattta ttcactctct gtttctgtca ttgtttctct tggactcttc ttgtctttcc 60ctgtctgccc cactgtctct tccaggactt tgtagatgtc tttcctctgc ttagaacatg 120ttttccattt tcccatttca tctttccctc tttgtgaaat ttacttttgt ttatcttttt 180gaactcagct tagttgtgac ttctaccagg acatattttt cttagtctca ggctgaatta 240ggttccccac ccatttgttt ccacagtata tttctttcat atttatggta ataattaccr 300tgttttatga tgcctaatta tttgtttgct tcctcactgt aagatttttg tatccttgaa 360tacagggatt gtgtcttatt caatattatg tgctaagcac ctagaccagc acattggaag 420taccgaataa atgaatgaac ttcctacagt atttagtcaa ggggcttgca tgcaataaat 480actctacttc ctaaatttta gataattttt tttgtggaca ctgtaacagg aaccagtcat 540tcagaaagaa agaggtagta tcgaaagaaa ggacaaaact tatgatctac ccaattttc 59933599DNAHomo sapiens 33ttttcagggt tctcaaaaga aaaaaagcaa aaaccttata tctttaaagg ataatatttt 60actcccttca ccttgaactt aggtttaaat taaaattagg ttgaatttag atttaaattt 120aggttttaaa atgtgtacat tctttcataa tcttgagata ctctgtttta tattactcaa 180taaaatgata aggttatttt ttacacttag gcccattata gttttatagt aaaatattca 240aaggccttgc tgtcatgaaa ggttttgcta cacataaatc aggcctgctt ggtacatagw 300gataaatgtg gtaagataag tcattcactc ttactgtcat tcagatggcc aatgatggag 360ctgtccttgt ttctccaaat aagttttatt atggagttct gccataatag tctggacaaa 420cagaatgaat ttaggtctca tagaccaaaa caaatttaga agtgtaaaac agtcactggg 480ccaattctcc caactatggc atttgtaatt tacatggtct caaaatattg aaaattagtc 540ttacaaataa aaaaaaagta caaaaaaaag gctttgcttc taagaaatac gagggttac 59934599DNAHomo sapiens 34tgttttctat agattagaaa ctatgaacca ggataaatta atcattcaaa atatgttaac 60acaaatgggc atttagttaa agctgagaga tatcatattg aatatggtgg ctagtctctc 120aatatgatgc ttaatcataa tttttaagag tcaaaaagac tttttttcta attagagcag 180acaatgtgtc agcatactgt agttcgaatt gactatatta ttgtgcactc atttttggaa 240tttcaagtaa aaacaagaaa aagcataagg gatctaatac agagctcatc tgtatttcar 300aagaattagg tcatgaccca tttcatatct taaagaccca agaaagctac ttgaattctt 360caaggcaaat aaagaataaa ttctttcctt tacccttgcc tgtagcagaa tttttctcat 420gcttgttatg tgatcaagtg atcactttct tagctataat cagacttgtc aagacattaa 480agaagaaagc agcagactct gggcttctac ttgcagcttg gaaaacgtat tagtgttatg 540gtatagccaa actcccatat ttgttaggat gactaaaaag taatttggct aagagcttg 59935599DNAHomo sapiens 35agagtaaatc atttttacag ggcatactga acaagtaaag ttattctaag aaatgaaagc 60tttaggtttc caaacagtac tggcacaagt gcaactggag aaagcaacaa taaacaacaa 120gtaataagtt atgttctttc ctgagaacac tgtttttaat caactgattc gccttgtctg 180agttgttacc ctatccttaa ttaaacatcc ttgggcagta tttctactca aaaaacaact 240gttttaagtt ctttgtctgc actatgaatg tcagtgtcta agggctaaca gattagtccr 300tagcaactta gaaaaaaggg atgaataggg aacagcattg gagagtatat gtcaaatgaa 360ttagggcagt agtttagtga gccaatgtgc caatttagaa atggattctt cttcctgctg 420aagagctctt tttaaaataa attacaatca taaagctgcc acagtttact gtgcatagac 480atgttcagaa ttggctcttc ttcatgaggg ctgcttggtg caggtattta agctactgcc 540aataaggcta acagctcatc aaatagaaaa tacgctgcag gaaaatacat gggttaaga 59936599DNAHomo sapiens 36agattctgat tcaagctttt tattaagata gagatagcaa aatagaacta aggggatgct 60tctggtaggt tgcttatgga tgccactatt ttcaaagaga tgacatttaa actaacatct 120gaaagataat aaggcaacta tgccaagatc ttgggaaaac gctgaaggtg ttgacttcta 180ggatcatcca ttagttcaaa aacagtagga aagaataaag aaacctcggg ttgcaaagaa 240cccagagtga ggcgtaaagt agtagaagat cagacagtag aagtgggcag aaccaccaaw 300ggccatgatt agtagtttga ttttattata aaagcaatgg aaaaccatta aaatatttta 360agaagaggag tgacatggtt taaatcagat tttaaagtaa cattctggtt gctatctgga 420gaatagattg ggaagcagga gtatagtggc tgagagcaga gaccctagat tcagacagac 480cagagcttat atctcagctt tcatgagtat attggaagtt ggataaaatg taaacatata 540gttatcaagg tatgattttt tttgctatat cagatcataa tttttaaagt actctcaca 59937599DNAHomo sapiens 37aaatggatga aggattgagg gaaaaagaat tataagaaag acaagaaaga gcagaccaca 60acactcaaaa gaagaaggga agataattta aataaaacaa aatagaaact ggtgtattat 120aaaagagagt aagtgatgac aaatgctaca gtacattaga aaatacttta gcttatgaaa 180tcactgatca gttgtcaatt taaagaaacg atgtgattgt gataataaat tccttagtaa 240gagacaacaa tgcgtttgag ggtacactac tctcatgaca aattaagaga ctatttctaw 300gagatttaaa actagagcaa ctaacattat gttgtttctt taaacaatat ggtcaaagat 360gagctccatc ttgatccaag ccacatggta attttttttt tttattttta agaaatttga 420agatatgaag aagaccatct tgtcttacca gtttctctga gggcatgtag catatacctt 480aaaaatgcat gttagtttga aattctatta aagataaatg tggaaatata tttaaacata 540ggatgagtca taatacttta caggaatttt ctcataatag gtgaaggcat aactgaaca 59938599DNAHomo sapiens 38tctccatttg aaaagccact ccttacttgc taatgaactt tggttaagac tgtgtactgg 60gccataggac tcggaatgac aatgtagccc aaaccgtgca tcatgaacta ggtgttatct 120aattcaacat atcaaaaatg tacacaacag catttccttg gtatattttc cttccctgca 180gccttcttat gctagttgag gaagcccaag tatactgtat gagcaagtag ctcagaggtc 240cctaatacct gctactactg cttctcaatc tttttgcttc aacccgtatg tatggcctcm 300tggggtattc tcagtgacta gttgatgagg atgaaacagt gtggatctgg tttgtaaata 360gaatgtctgg aattcaatac cagctatgac tatggtgttt acaggtccac ttaagggaga 420gggccctgaa atacagtggc tatcccacca gcagccagaa tttcattcag ctagtacatt 480taactgcaca ctttgcatgg aagaagagat agttgaggta atgacatatg gcatggccat 540atggtcaagg acttcaaaga acaaaattgg acgactggtg acagaaagtc tagggaaga 59939599DNAHomo sapiens 39tacgtgattc taatgcaatt tcctgtgggt atgatttctt agcagaaaga gctggatatg 60gaggaagtgt ccctaaaatc atttatccaa aaaatcattc aattgaagta cagcttggtg 120agtaaaatta ttgaagccat tgaaatcacc aggggaagag ctcattatgt ttgcatattc 180tggtgaatat tttgaatgtt aaggatgaag ataaatccta tacacaccca gtttccagct 240ttggatatac gtgagctcat ggggagagga atcaaaataa aacaccagag agccgaagcr 300tggaaaagtt gtggtagcag agaagtctgg caatgaggac tatgggccca aaatgattat 360tataaatctg tttatgcaaa ggcaatgaaa atgcaaataa ttcttcagac aatacataat 420ataatataaa actactatta aataatgttg accaggagtt ctggattata ttacctcaca 480atgcaagata tattacagga gtgaaaaaaa ttatgatgtt atattcctta atctatatgg 540aaaaggatca ataagcattg cctcaatttg tgatctaagt agataaaaag gcatcaaat 59940599DNAHomo sapiens 40gcacagaaac ccaggatggc agcatagaga ggggaggaaa tcaccctttc tctgtcactc 60tgtttccccc accaagattg acttggagcc aagagaaact tctctttgca gggaaaaggt 120aagcagaagg cctctgccac cttcattatt accacagaca cctgcagttc ttgctacaga 180agaaagctgc agtcctcaca ggtcctgagc ccagtttggg gagcagcctg gagttctcat 240ggctatattg ctccagtgca ggaaactaca ttgtgcatac ccttatcccc tatgacccay 300gctgctacat catgccactg tcttggaatt atagctactg ctagagtgag tcctgttctg 360ggggccagta gccactgcat ctctccatcc ccaatgcttt cccgtcattt caccatgttc 420atacaggtgg ctacaactcc aaaatcctgg ttacttagag tatgggccct atgaaattac 480tgtgatcctg gttcccaaat gcacatggtg ccctgcttcc tgtatggaca ggcagtcctg 540cacaactggg gaagctttcc ctagccagca gacctactct gctcaccctc atacccatg 59941599DNAHomo sapiens 41atagaattat agtccaagca aggcaaagtc agtttccaat gagccaatgt gcccttgtca 60caggccaatt tataacttaa tgattaaagg tttttaatac taaaaattag ctgtaaaccc 120tcatcacttt tttccaagac cctggcctga gggaattagg catagctcaa ccttctgaag 180ctgtgggttg ttgacactga gacttagtaa gcagtcagtg ggggctggaa gggagtcagc 240cctgagagcc agccggcagg ggcgagagag ggagccagag ggtgtcagga ggcctgtggy 300cttaggatgg catggggagc agggtgggtt aggaggtgct gtgccctcgt tcacaggcga 360tgggtggtac ccagtgtggg atggactttc aggtgctaag gaacccactc ctgtctttga 420agagtttatg ttccaaggtg acctcacatt acacatttgt ttagcatcct atggaggcct 480cgacttgaca ttggtccact ctttatttaa catttgcttt ttaaaatttt tatttcggta 540aactatatga acataaaatt caccatttta acaattttta agtggcatta agtacattc 59942599DNAHomo sapiens 42taaaaagtat ttttgagttg agatcaataa actggtttga agtctaaggt ttcaaacata 60agtaagacat gaatcttgaa aataactcaa ttaagaaata agtagaaaag atttcaacat 120aaggcaataa aagataccct ccttccacag cgaaatatca ccttcaacca aagtttcttt 180ttcttgaatc aattttatta tgtttaattt tcatatggtg taggaagggc aagggaaatg 240gggcatggga ggtcagagag aactttctgg agaatgtgat ccccacataa aggaatgtcr 300gctggaaacg gtggatgggg tggaggtgga tgtggccgaa gaccttgtct cacacgaaga 360agaagcataa aatcatgaga agtgttcaga gccccacaaa gacttcaatt tctcaaaaca 420tgaagtcaag aatgaagagg ggactagaag gtggaggttg gggtgaagaa ctcaagaacg 480aggagaggga gaagggtgtg ggagccttga acaggcacag ctggagaaag acttagtggt 540attacatttt taaagatttc tctgctcata aatacttgaa aaaaaacttg aaaatgcaa 59943599DNAHomo sapiens 43tgttcatttc aaaacttgta tatttttaag tctaacttta caaagaagag gagataataa 60caaggaccct gataaattaa ctatgtatgt gtggggtgta agagacacta aaacacaatt 120ttacacaaaa atcaaccctg atggtaccag tcaaataact gggtcttttt gtgaaaaaga 180aatgaaaata cctcccagta gccacaaaat actgtaatct tgtggttcta agaaccttta 240gtgaataaca gtaagacatg gttggatttt gtgttgattt caggttacat ttatttcagy 300taaagaaaag gtgtaaactt gtgagatata tcatttctcc agacttgagc acatggagag 360gattacctgc atgtgtgttt ggtgagagga agggtacaat agcctagaga ccatgtctga 420gatgacatgt cttttagaga agctgaatta gcatttgtga tcaatggtta cttccaatca 480ccactttaca agaaaaagtg attttagcac cttcgtttct gagaaaggca atgttctcag 540aaaggaaagt ttttaactct gttatttgct gctctcagga gatacttgtg gttttgaga 59944599DNAHomo sapiens 44ttgcagtaag ccaagatcac accactgcac tccaactggg acagcaagag tgaaactcca 60tctcaaaaaa aaaaaaaaaa aaaatatata tatatatata tagaataaca tttgtaaggt 120tatagagcaa aatgatgaca aaggtttgag tggtgggatt acaagtaatt ttgatttctc 180tcttttttgg ttatgttttc tatgactact attattgctt taattagggt tattttaaaa 240tcattctcta atctagctcc ttctagatat gcatgtttaa gccttaaact cttctctacr 300cctttgtgtc ccaaactgca ccgctatagt gcttagctac aatcccaggt ttacaagaag 360tactgaactc aaaccagcaa acatgggtgg gctccactca gggtcctgac ctaaggtcat 420cgaacacaaa tggaggaggc agattcctta tcaagagtac aatccaagac aaactgacat 480aagtgctcta taaatgtgta accaggatgc aggactcaaa gggaagtccc aagccaggag 540gaatgcacag agccctccca aaccaagtga catcggagaa tgagaaggtt tcccctggc 59945599DNAHomo sapiens 45ctgatttctt aatgtacacg gcatatttgg gaaaaataga agatttgggc ccgagtgtca 60agtatgagga taaaatgcat gtgttgaaga agaaatctgg ggaagtccca gcccttactg 120tacctttgtg tgaaaagaaa ggtacctcct ttgcagagaa aagtacctcc ttctctgagc 180agactcaagc tcagcccagg tcgtgggacg aacttagtga ttggaggatg ggttgggttt 240tagttgccac ttgctccatc agctggacac actcctgcag tgtacaaact gaacaacggy 300tcctaccaca atgctgtgag gtaaggatac agagctcaaa gaaggtaaat aatttgccca 360tattttgagc aaggacatgc atccagagtg aagactctta agcaatgaat gtggacatga 420ttccatgggc tgtgggaacc attgctggtt attgaggagg aaatgaaatt gaatgcacta 480agactagggc acacatggag aataaacagg aagctattga acgctcctgg tgagacatga 540tgagacctga atttggacag tggtagtgag taatgaaaga agtgaagaag tgtgatgga 59946599DNAHomo sapiens 46ccatcggcat ttgctgatag ttgaaattat gagaatttat gagagtctct agaaagagaa 60ggaaagacag atccttagaa aatgcctaca tttaagagga atcagtgaat gaacccaaaa 120atagcaatca gagtgaggga agggacacaa agaagaaagt agggtgtcat ggaggccaag 180agtagagtgt caaagaggaa gtggtcaaag tgtcaaatgg caccagtgta gaacagatga 240gagctgagaa gatttcatta gcaagtcagt cagaaggcaa tccattacct tcaatgagcm 300gttcaaaccc caaggttcca gggggtaggt gtgtggtggg ggcggtgaag gctggagtag 360agctcttttg taagaatttg ggtagagaaa ggaaggagag aggcagggca gtggtttcat 420aggaaagtga agaccaggga aggctttagt tataggggca tgtgtgtcta gaacatgctt 480agagagcgag tgatacagac atcactatct gaagctgata gatacagacg tcagaactga 540gacatagaag aaccctttga aaggtgagac tgcattggga gctgggagga ttgagaaat 59947599DNAHomo sapiens 47gtttgttcac attttctaga aattgatata aatggaataa tacagcatgt gcttgtttct 60ctctggcttc ttctattctg cgtaattatt gtgaaagtca tccatatgat tgcatttatc 120agtacattca tactattgca tttatcaata tgtcattctt gttgattgtt tatcatattc 180ccctattatc ttcttaacat ctatagaaac ttagtggtgt caactctctt tttcttgata 240ttagtaattt gtgtcttctt tcttttttcc tcagtcagtg tgactagaga gttatcaacy 300ttattagtct tctcaacaaa ccagcttttg gcatcattga tttttcttta ttgtttttct 360gttccatctc actgttttct gcattgattt gtattatttc attttcttct gttttctgtg 420ctttctttgc tcttcttttt ctagtttttt aaggtggtaa ccaatattga tttatgactt 480ttattatttt ctaatgtatg cctttagtgt tgtaaatttc cctctttagt ggcatatccc 540aaattttgat atgtagtgtt tttgtttcca tttagttcac aatactttct aactgccct 59948599DNAHomo sapiens 48ttattaagta aaaaattcta aggtgacttt ttctttcagt catttaaaga ttttattctg 60cttgcattgt ttctgatgag aaatctgatg tcaccctctc cctagttcct ctatagtaac 120atggtttttt cttttctcac ttttaagagt ttttctttat cactattttt agtgtttgag 180tttctgggta cttcagggtt ttatactttt catcaaattt gcaatatttt ggcgttattt 240cttcacataa ctttttttct gtccttttgt tcactccttt cctcctggaa cttcaattay 300acttacatta gatgactcga aatttcccca caattcacag atgctgtatt tttttcagat 360ctgttttctt tctgtatttt attttgcgta gtttctattc catacaatat atttttcatc 420tgaaatgtag cttttatctg tagatgtttt atttaggtct ttttaaaatc tgccatatct 480ctgcttaaca caatatttca tataggtttt tttttcacat atggaatttg gatataatag 540ctgttttcat gtccttttct acttattcta tttatctatg ttaattcttt gctagtttt 59949599DNAHomo sapiens 49gaagcaaaaa ctcaacctta ttttatggtt acaccatatc atgtgcattc agatctttca 60tgattccata atgggtaaaa aaccttcctg tgttcagaag ttaaattggc tgttttttat 120tttactgagg cagttagcct taataattgg ctcctatttg tctgaatatg aactgtaggg 180atcaaagact ttgctgaatt cattctcttt cttgtccact ctttaagaaa ttagaaatta 240aacaaggcat gaaagctagt gtgtttcact cttccccctt actcctattc caaagttcas 300aaaaagtcta tgtttagtta agagttaaca gaggtgcttg

attttgagtt tgtggaatag 360aagttatgtt aaagccacat gttcacccgg aagaaaaaaa ataattttgg taaaaaatta 420gatttttata ttctctctct ctctctctct ctcacacaca cacacaattg ccccttcctt 480cctcatcatt cttttgctta ttaagcaaaa aaagtttact caattttttc tataaaacac 540atttagatct ttccacattt taacaggatt cacatgtccc ccaccagcct tgaatagtt 59950599DNAHomo sapiens 50ctggagcacc gtggtgcagt cttggctcac tgcaaccttt gactcccggg ttcaagcaat 60tctcgtgcct cagcctcctg agtagcttgg attagaggtg tgcaccatca cacgcagcaa 120atttttgtat tttagtagag acggggtttc accatgttgg ccaggatgtt gggattacag 180gcgtgagcta ccatgccctg ccagaaggtt tgtttttatt ttaaacacaa ttgtgctggg 240tgtgatagga tgggtatatg atagagcaga aaatcactag tatttcatca atatggatar 300catcctccat aggttactga tttaatattg acaacaatac ccttcacacg agagagaggt 360tagagaattt gcccaaagtc aagcagctgg gaagaggaaa actaggctgt gctctcccta 420aatctcatgc tctattatat tagggaagac tctggcagat ggcacatcct gattatttga 480aagtcaccaa tatttttaga aattgcatag ataattaagg ttagtttatc cagaattcta 540ataattgcag cacatgtcca taaatctcta ttacaaccac ctgagatagg ccatctcgg 59951599DNAHomo sapiens 51cgccctgcct aactagccct ttcctttctc tttcttggaa ctggactctt ggttgctgtt 60agatttttgt tctagaacca gagggatctt ttccaccaac ctgtagtagg accctactgc 120acatgcacgc gcatgcaagt gcacgcacac acacacactc gtgcacacac acatgcatgc 180tcccacaatg ttggcatcgc cactgttgta agactcctgc attgtatcct cccaaccaga 240ctgcatttgc ccttggacat ggatgtcagc ctggctcaaa gtcatcaccc aaatccttgy 300ggggctctcc cttgcagttg tctgcctctg cactcccaga aaaccaggaa gtatggagga 360gtgggcagag aaatataaac ccttgtgatt ataggacaaa tattttaaag gacatagagg 420aagaattctc ctagaggaaa aacaggtatc cgaaaactga agacacccca gatacacttg 480agctatgcgg ccacatctcc aaacacagag gcacccaagt agaaaagtaa cttggaatca 540atctcctcac ctaaacaacg cattcaagaa cagagagaat cccagatcct gctggggat 59952599DNAHomo sapiens 52tccttagcac gcttggaata acatagcagc agcagcagca gtcgacactt actaagactg 60ctatgtgcca gaccctgaga caagcacttt ccacacacca catcctgcca ttcttatgat 120gatagtgctg tgaagtaggg atgaaaccaa gtccttgctg actccaatct tgtacttcca 180accaatgctt gtgagggccc caggccccct acagcaagac taaacatgga catatgtgtg 240gctgggctga gtctgtggga ttggctctgg agttgggtgt gtctgagccc tgggtagaar 300gggatgctat cctaatgaaa aaacacagaa taaagatagt gtccaccaag atgtaactga 360gatttaaaga agacttgata acttatcagt tgggtgggta gtcttgaatt tcaacaactg 420cagatcctat ctaagaccac ttttgtcttg tgacaactta gttaaacatg actttagtgt 480ggatatcagt ggccaatttt gagcccattc tatgattgga acaaaggctt ccctgtcata 540ggtgagtgac aactatctgg tctggtggta caggggtaaa agaatttact aagacagtt 59953599DNAHomo sapiens 53ccagaccctg agacaagcac tttccacaca ccacatcctg ccattcttat gatgatagtg 60ctgtgaagta gggatgaaac caagtccttg ctgactccaa tcttgtactt ccaaccaatg 120cttgtgaggg ccccaggccc cctacagcaa gactaaacat ggacatatgt gtggctgggc 180tgagtctgtg ggattggctc tggagttggg tgtgtctgag ccctgggtag aaagggatgc 240tatcctaatg aaaaaacaca gaataaagat agtgtccacc aagatgtaac tgagatttar 300agaagacttg ataacttatc agttgggtgg gtagtcttga atttcaacaa ctgcagatcc 360tatctaagac cacttttgtc ttgtgacaac ttagttaaac atgactttag tgtggatatc 420agtggccaat tttgagccca ttctatgatt ggaacaaagg cttccctgtc ataggtgagt 480gacaactatc tggtctggtg gtacaggggt aaaagaattt actaagacag ttgtagataa 540agaaaggcag atttattaga gaaagtatga aaatacatta caaggttgca atgggcagc 59954599DNAHomo sapiens 54tatcagattt aagaatgctt tcgtcataag ggtggaacta gaaatcagag gtgagtgaat 60tagtcctgga tctgacccag cgaccagagg cacaaaccat cactggcaga ctgagataag 120gggaggatga aagtggcagc aaacagcctg aagacaaaga aaatggaaaa acctaaagga 180tccatgttta cattagacct ctaatttcct gaaaatactc ccttaatgaa agcaggaacc 240aaacccactt taagtaattc atttggttgc tatgattgag gaatgtgtta gtttcaaaar 300tcttaatgta gattatattt tgaaaaggtt attcactttg cataggggct agttttctag 360ataattcctc taaagggtga tttttctggt gtcttgagag ttggtgtgta cgttcgtgat 420ctggcacaga ctagtcaggg tgcacaaagc agctcagatt tccagaaacc actacttaag 480aaaaaaaggt gaaatgaaaa gaaaataatt ttgcacatta caaccccaaa tcagacaagg 540ttttgctcaa gaagagaaaa atgatgaggg aattcctcac taaagtctcg gtctttacc 59955599DNAHomo sapiens 55agaatatcta tgcccaccag attacataaa aagtatgaga tgaggttcgg gaaataagat 60aaagatttat aaactggaat tcagaatgtg gtttatggaa agatttaagg taaattagca 120tatctcagct cagggacaga caagtcttag caggactcct cctatcaaag aaatcttatt 180tccattttct tcccattttt ctgtgctcaa gacatgatta actaactgca gagacatgcc 240aaagacaatc aaatcctttt ttatgtgaat atcagattta agaatgcttt cgtcataagk 300gtggaactag aaatcagagg tgagtgaatt agtcctggat ctgacccagc gaccagaggc 360acaaaccatc actggcagac tgagataagg ggaggatgaa agtggcagca aacagcctga 420agacaaagaa aatggaaaaa cctaaaggat ccatgtttac attagacctc taatttcctg 480aaaatactcc cttaatgaaa gcaggaacca aacccacttt aagtaattca tttggttgct 540atgattgagg aatgtgttag tttcaaaagt cttaatgtag attatatttt gaaaaggtt 59956599DNAHomo sapiens 56cttgacaggt tatttttgtg atgtctggaa tatagacaag tgaaggcatt gagtcagcag 60gtggacatga gaacctgaag ttcaggggaa aagtgtggac ggcaggtgta actgcaagag 120tgtaatcagt atagagatgg tgtttcaaac cagttaactg gatgacatca tgtggggagt 180gagtgtggac agagaagaaa agtgcttcaa ggactgaaac ttgaggtggt ggagagaaga 240ggagatgtga agcagtagcc tgtgggtcct gaagaaagat gttggagaaa ttgttccacy 300ttgacagagg ctgcttatag ctcaaggtaa ggggaagacg caggactgag gattcctaag 360caacatggtg gtaattgacg atattgataa cagcataaag acatcataat ttaaactaat 420tattaacaaa attgaaattt aaagaaacaa gtaatgcaat gtttccaaag tggattcaaa 480ttccataata ttattgcaaa acaaacaaac caaacaaaca aggaaaacaa agaaagaagg 540gattctaaca taaaagaatt taaaaataag taaatcagct cggaaaactc agcaggcta 59957599DNAHomo sapiens 57agtaaatcag ctcggaaaac tcagcaggct atatcttcct ggtggttaga aatatctgct 60tattaaaagg tttcaaaggt cctttgggaa tagaacttat tgcaatgtgt ttggctgtac 120atttcttaca cttttttttt taactgagga gtcaattaaa atatcctgaa gtgactgtcc 180atagaacaca ttttgaaaac acaaatgcta tataatcaca aatatatctc cctccccttt 240gctagtgatt gttaccaaac tgcctctgct agctaggatt caactctttc tcttaacaam 300tatgctttga tggaacaatt tttttagata caaatattgt caatgagaac aattattata 360cagtgcagtc acagaagaga aacagaaaag aaagggaggt gcaacaaaat gaaggtaaat 420attagccttc acacttaaat acatttgatg aggggataaa atgtacatgt aggtgtggat 480ttatgggctg tgtttttcaa acaattacca aatatttatt aaccaccaac tcagtgtaag 540ctagtacact aggtgcctat agtgatccag caggctataa ggcaggattt ctgccctta 59958599DNAHomo sapiens 58gatacaaata ttgtcaatga gaacaattat tatacagtgc agtcacagaa gagaaacaga 60aaagaaaggg aggtgcaaca aaatgaaggt aaatattagc cttcacactt aaatacattt 120gatgagggga taaaatgtac atgtaggtgt ggatttatgg gctgtgtttt tcaaacaatt 180accaaatatt tattaaccac caactcagtg taagctagta cactaggtgc ctatagtgat 240ccagcaggct ataaggcagg atttctgccc ttatagaatt ttggggcata ttctcagtaw 300cttttgtatc tctcgccctc ttttcttttt tttgtgacac aagatgtcat tctgtcatcc 360aggctgtagt gcagtgacat gatcatggct cattgcagcc ttgacctccc aggctcaagc 420gatcctcttg cctcagcctc ccaagaagct gggaccatgg gcatgtgcca tcatggcaga 480ctaattttta aattttttgt agagatgggg acttactatg ttgcccaggc tagtgttgaa 540ctcctgggct ccagcagtcc tcccacctca gcctcccaaa gtgctgggat tactggtgt 59959599DNAHomo sapiens 59gtgagacaga gacggtggct atgaccaggg cggggaagtg caggtggtga gacatgattg 60ggatgcagat agattttgag ggtagaacta gtaggacttc ttgatggaca ggatatgaga 120gcagtcaaga gaggtttggg gccctgagta actggtcaaa tagggttgct agttactgaa 180ttaggaaatg gcaggtggta taggttttag agtaggatta cactagtttt ggccatattc 240agcttgacac ctcattagac ataaaactgg agatgtgaac ccatcagtag gatgaataty 300tgcttctgaa attcaggaga catattgggc tagagataca aatttgggat atgtcactgt 360atagatgaaa ttaaacccat gagaccaggt aagatcttca aaagagtgga agtagctagg 420ccatgagggc acaatagagc aacttctgat tttcactgta aaacatccca gagaataagt 480gttcatcctt ccctgaagga tgaatttgga tctctgcata caacactgca gaggtggtga 540gcatctggca tgaagtgacc ctgagttctg acccaggcca gctgcactga cctcaccac 59960599DNAHomo sapiens 60gggaaacaaa aatctcctgc ccttgtggaa ttcatgtcct acaggaggac aataagtaac 60ataaagaaat aaaaaaaagt tacaaaagat cttagagtgt gatccactta aggagaaaaa 120tacagcagga ggagagcaat ttcaggccag atgtcctggg aaggccaact aggaaggaga 180catttaataa acagcccagg tcgaaagggc aggcagcatg aaagtccagc catggaggca 240agcctggtgt gtccgagggc cagtagggaa gccacatggc caacagggca tgaggaacty 300cagagcagtg agagctggtt ggagaggggt agagactaga ttgcgagtga gtcaccctga 360gcaccttggc ttttattaag tgtgatgaag accactggag tgtttcaagc taaggagtga 420catgacctca aacttgacgt aggtattaaa cactctgaat gtgaaaacac tcttaagaat 480ggcaagggat gaggtatcca ggtgagacag agacggtggc tatgaccagg gcggggaagt 540gcaggtggtg agacatgatt gggatgcaga tagattttga gggtagaact agtaggact 59961599DNAHomo sapiens 61ccacagtgct gtccttctgg ccatccttca tgcttttgtg ttgcctgtcc cattgccctt 60aatcttatat ggaaaaatgg aaataaattc agagcggaaa cttatctaaa agttttgagg 120gaaaaatgat cgaaaccaga attattcaca ggacaacttg ttctatgaat aatttttgaa 180aaggaaccat ttcctctaca gctggcttat tatgaggagc ttgatgataa aatattggca 240aggcctccag tggacattta tcgtgttgtg acagatccca gaaatgaatc tgggtctccy 300gacttcaata cagttctctt cttattacat aatgagagaa tatgattttc tactcttttc 360ttttacttta cttgttgaga aacaactaat attcaattaa aagcatcaat cttacatatt 420cagttgaatg agattcagca atcatatccc ccatgtatca tcatccatat caccatccca 480acagcacaga aagcatttct tcttcccaga gagttgccct cacacctttc caatcaaatt 540tccacatact ctctagtttc cagcatgata gattataatt tgcctattgt tgggcttcc 59962599DNAHomo sapiens 62tatatatata tatatatata tatataaaac ctaacaaaaa gttaaagaac atctactgta 60tggctcaata actcccccct tacccaagag aattaacaaa catatccaca aaacacttgt 120aaaagaatgt tcataaatgc catactcata ataccaaaaa ttaaacataa tccaaatgtc 180tatcaacagg agaatggatc ctttttttaa tgtaaactac tcagcaatga aaaggaagga 240aatactgata taaccatagg atgactgtca aaaacatcat gttatgtaac tctgagttcr 300tttccaaaca aaaaaataat aaagccttgc tcctgaaaaa ttatgctaag caaaagaaac 360taaacacaga agactacata ttacatatca tacctatagg aagcccaaca ataggcaaat 420tataatctat catgctggaa actagagagt atgtggaaat ttgattggaa aggtgtgagg 480gcaactctct gggaagaaga aatgctttct gtgctgttgg gatggtgata tggatgatga 540tacatggggg atatgattgc tgaatctcat tcaactgaat atgtaagatt gatgctttt 59963599DNAHomo sapiens 63gatccattct cctgttgata gacatttgga ttatgtttaa tttttggtat tatgagtatg 60gcatttatga acattctttt acaagtgttt tgtggatatg tttgttaatt ctcttgggta 120aggggggagt tattgagcca tacagtagat gttctttaac tttttgttag gttttatata 180tatatatata tatatatata gtgtgtgtgt gtgtgtgtgt gtatatatat atggtgtata 240taatttatat acactaaaat acacacattt ttaagtgtaa agttcaataa gttttgatay 300atgtatactc cattggcttt gttttgtatt gctataaaat aatacctgag gctgggtaat 360ttattaagaa aaagtttatt tggctcatga ttttaatggc tgcaaagttc aagactgggc 420aactgcatct ggtgagggcc tcaggctgct tccaatcctg gtggaaggtt aaggggaggt 480ggcttgtgca gagatcacat gggagagaag aagcaagggg tgggggagtg ctaagttctt 540tttaacagcc agctcccatg ggaagtaata gagtgagaac tcaccaccaa gggagggga 59964599DNAHomo sapiens 64ctcaccacca agggagggga ttgaaggagg gaattaatct attcatgagg gatccacccc 60catgacccaa atgctccccc ttaagcccca ccttcaatat tggggatcaa atttcaacat 120gaggtgagga gggtacaaat atccatgcat accacctctg aaaccatcat ctcaattgac 180atattccaca aatctctctc atactccttt ataagtaatt gctacccttc atcttccatt 240ctaggtaccc actcactggc cttgcagttt gggaacatta tataaatggg acgatataay 300atgcattctt ttaaaactgg cttctttcat tcagtatgtt tctaagattc atcagtagtt 360cttttttttt tttttgctga gtagtgttcc attgtatgaa tatagaatag tttagccata 420tatgtgctga cggtcattgg tcttgtttcc agtatttggc tatatgaatt gaactggtat 480gaacatttgt gtacaagtct ttttgtgtgc ataagttttt atttctctta ggtaaatccc 540caggaagaga atttctggag tgtaacacaa gcacataatc agaaactgcc aaactatgt 59965599DNAHomo sapiens 65taaaaaacct gcacgttgtg cacatgtacc ctaaaactta aagtataata aaaagaagaa 60gtagaatctc attgtgattt taattgttta catttatcta ataactagta actttgtgca 120ctttgtcctg tgcttattga acattgatat attttctttt gtgaaatatc agtacaagtc 180ttttcctcat tttaaaaatt gggctatttt atctttttca tatgaacttg taagagttat 240ttatgaagta tagatacaag tctttcatct gatatgcaaa ttatgagtat tttgtctggw 300ctgtggctta gtctattcaa attctaatga tgtctttgaa gaagaaaagt ttctaatttt 360aataaagtcc cagctatgat ttatttttct ttcatgatta gtgatttttg tatccattta 420aaaaatatgt tcctacttca ggtttaagat gttctgttat gtaatacaat ccatttttat 480ttcatttttc tgtataatat gaggtagagc tttttcacat agagagtcaa tttttctatc 540attatgtgtc gaaggcagtg tttttcacaa taaacttatg ttggcacttt aatcaaaca 59966599DNAHomo sapiens 66tcttccacca caaacccata gccaccacca atctgctttc tgattctatg ggtttatcta 60ttctgaatat ttcctataaa tggagtcaca caataagtgc cctttgtgac tgccttattt 120cacttagcat aatctttcca agttttgttc atattgtagc atgggtctgt actttattgt 180ttctaatgac tgaataatat tccactgtgt gtgcctacca cactttgttt atccattcat 240cccttaatgg gcatctgggt tgcttctagc tattgactat tttgaataat gctgctatcr 300gtgtccaagt atttgtttga gttcctgacc aatcaatttt gaattgcaat gtctcctctc 360ccaatcccca tctccttaac ctgctccaat ctttttctaa ggcattcatc acttctaaca 420ttctacttat gcatcatgtt tattattttc tgttttatcc attggaatat gacctccaga 480aggcaatatt atttttgtga gttttgtcta ttgatatagc tcatgtgcct ggaagagcac 540caagtaggtg ctcagaaatg tttacttatt atcattatta ttattatttc tgaggcaag 59967599DNAHomo sapiens 67ctggaggtca tattccaatg gataaaacag aaaataataa acatgatgca taagtagaat 60gttagaagtg atgaatgcct tagaaaaaga ttggagcagg ttaaggagat ggggattggg 120agaggagaca ttgcaattca aaattgattg gtcaggaact caaacaaata cttggacacc 180gatagcagca ttattcaaaa tagtcaatag ctagaagcaa cccagatgcc cattaaggga 240tgaatggata aacaaagtgt ggtaggcaca cacagtggaa tattattcag tcattagaar 300caataaagta cagacccatg ctacaatatg aacaaaactt ggaaagatta tgctaagtga 360aataaggcag tcacaaaggg cacttattgt gtgactccat ttataggaaa tattcagaat 420agataaaccc atagaatcag aaagcagatt ggtggtggct atgggtttgt ggtggaagag 480gaagaatggg gacttcatgt taatgggtat ggggttatac tcggggatgg tgaaaatgtt 540ttgaaactag atagagttag tggttgtacc acattgtgaa tgtaccaaat gtcactaaa 59968599DNAHomo sapiens 68cagatgccca ttaagggatg aatggataaa caaagtgtgg taggcacaca cagtggaata 60ttattcagtc attagaaaca ataaagtaca gacccatgct acaatatgaa caaaacttgg 120aaagattatg ctaagtgaaa taaggcagtc acaaagggca cttattgtgt gactccattt 180ataggaaata ttcagaatag ataaacccat agaatcagaa agcagattgg tggtggctat 240gggtttgtgg tggaagagga agaatgggga cttcatgtta atgggtatgg ggttatacty 300ggggatggtg aaaatgtttt gaaactagat agagttagtg gttgtaccac attgtgaatg 360taccaaatgt cactaaattg tgcacttcga aatagttaat tttatgttat gtaaatttca 420gcgcaatttt taaaaatcag aagcaaaaaa agaacagaaa attgagtagt taggctaagt 480ctcacagaga atgtacagtt tgagtgctca cttggaggag gtaagttagc tcttggagga 540ggtgggtaac aggaagaagc tgtccaggca gaaggaacaa tgtctgccta gtgccttca 59969599DNAHomo sapiens 69tgtctttttt atacactaat ttcttttcct tagaaaagta gtgagatttc tgggttgaat 60ggtagtttta cttttggttc attgagaaat cttcatactg ttttccttag agattgaact 120aattgacatt cccagcaaca atgtataagc attccctttt ctccatatcc atgccaacat 180ctgctgtttt ttgagttttt gataatagcc attcagacgg gtcttctggt ttttggaggg 240gaggattggg tgaagcaaga aggagtttgg agggaaggag tggaggcttg agtgggcctm 300gagtttggag tatgggcaag aaggatccca gagacaagca ctttgcccac agctacacag 360ctaatggagc tggggggccc agcatattct ccagaggccc aggctaggcc gtctaggggc 420atgcttgttc tgccccatcc actgcaggtc ctgaaaacat tttcatcaat aaaaaaaaat 480aaaaaaacag aataaaaatg atacccagat gtcctctagt gaaatgaggg gaaaaaaaac 540atccatcccc agcttattgt gagagtcact gaatgagagc ctgactcact gaaattcat 59970599DNAHomo sapiens 70acaaaaaaca aaagaacaaa caaaacctta tgttttgagg gcaacaacta actgctggca 60tatggaatgt gacactcaaa tacttccgaa cttagaaggt atctttcaag acttcttcat 120ttgacttagc agatatcaca ctgaaatgta aaatgtaaat gtcctaacac actccagagc 180tggccatgtg tggcctgctc ttactgtaaa ccagtgtcaa aagacaggga acttggttac 240attaatctta tatgaatttc agtgagtcag gctctcattc agtgactctc acaataagcy 300ggggatggat gttttttttc ccctcatttc actagaggac atctgggtat catttttatt 360ctgttttttt attttttttt attgatgaaa atgttttcag gacctgcagt ggatggggca 420gaacaagcat gcccctagac ggcctagcct gggcctctgg agaatatgct gggcccccca 480gctccattag ctgtgtagct gtgggcaaag tgcttgtctc tgggatcctt cttgcccata 540ctccaaactc taggcccact caagcctcca ctccttccct ccaaactcct tcttgcttc 59971599DNAHomo sapiens 71gggttattaa aataagctag tctataattt cttctttgaa aagaactaaa ttattttggc 60ttctcactat tcaggcacca ttcaacataa cagagagtag tttatagcaa cttaagacaa 120actgcaaaaa ggcaagggct tctaatacat gaataaagca aggcatttta agcacccata 180aatttctgcc aacttaatca gaaatcttcc agtgtccgct tgtttctctg gcaaacaccc 240acttttttaa gacttctcat aactactctc ccttttcaga ttaatctcat agaatctaas 300ctcattgaac cagctttttc ttaattttgt tacagttttg aaatcctgta tgtgcctatt 360tataatctac ttcacttaca taaccattaa aaaaacaaaa aacaaaagaa caaacaaaac 420cttatgtttt gagggcaaca actaactgct ggcatatgga atgtgacact caaatacttc 480cgaacttaga aggtatcttt caagacttct tcatttgact tagcagatat cacactgaaa 540tgtaaaatgt aaatgtccta acacactcca gagctggcca tgtgtggcct gctcttact 59972599DNAHomo sapiens 72gatgaaattc tgcaggagta tttattaaag ttgaactctt cctataaaat aattcagttg 60ttcatttgac aattaagacc tttcattcaa agtacaatac tctgtggtac ttatcattaa 120catcactcaa attttatagt tacaaataaa aacccaagga taagactgtt taagtaattt 180gacaaagttc acccagttgt ggctggggtt gaaaccagac ttgctgaact tcaaagtcaa 240gcttttctcc ccccaatgtc aactaaaaaa agagaacatt ctctatacca gagattaggs 300tggtaaagct tttcttttta taatttggac tgggttatta aaataagcta gtctataatt 360tcttctttga aaagaactaa attattttgg cttctcacta ttcaggcacc attcaacata 420acagagagta gtttatagca acttaagaca aactgcaaaa aggcaagggc ttctaataca 480tgaataaagc aaggcatttt aagcacccat aaatttctgc caacttaatc agaaatcttc 540cagtgtccgc ttgtttctct ggcaaacacc cactttttta agacttctca taactactc 59973599DNAHomo sapiens 73tgaataggtt tgttcaataa aataacacaa actcggaatt cttttacatt tggtatccca 60aaacatcttt ttaaaacatg tattaagttg gagcattcat tcttaaacta ggccacgtaa 120gcattagttt ctcagtttaa aaaataaagc ttccatcaat tttaacatca taatgatgaa 180attctgcagg agtatttatt aaagttgaac tcttcctata aaataattca gttgttcatt 240tgacaattaa gacctttcat tcaaagtaca atactctgtg gtacttatca ttaacatcas 300tcaaatttta tagttacaaa taaaaaccca aggataagac tgtttaagta atttgacaaa 360gttcacccag ttgtggctgg ggttgaaacc agacttgctg aacttcaaag tcaagctttt 420ctccccccaa tgtcaactaa aaaaagagaa cattctctat accagagatt aggctggtaa 480agcttttctt tttataattt ggactgggtt attaaaataa

gctagtctat aatttcttct 540ttgaaaagaa ctaaattatt ttggcttctc actattcagg caccattcaa cataacaga 59974599DNAHomo sapiens 74agttcaactt taataaatac tcctgcagaa tttcatcatt atgatgttaa aattgatgga 60agctttattt tttaaactga gaaactaatg cttacgtggc ctagtttaag aatgaatgct 120ccaacttaat acatgtttta aaaagatgtt ttgggatacc aaatgtaaaa gaattccgag 180tttgtgttat tttattgaac aaacctattc agcacttggg gaatcgcagg cagcattgca 240gactcgctgg ctcctggctg tgatctcaca cccaaactgc aataatatcc tgataaaacr 300gacttccaca agtaggtcaa gaataataat gtgcagacct aattcctcta atttacggcg 360aacatctcat ggtcaatctc cccgcggtca aaggactgtg tatctcttcc tctcagagcc 420actccacagg ctgaaaggct gactaaaccc ctgacagata agagattcaa gagtagtccc 480agcccccatg gggagcaaag acgctggctc aaaaaacgta ctgataactc tcccttttgc 540agctactcct ttctgaacct tccacaagca gtggcagttg gattctgtga ttagtctag 59975599DNAHomo sapiens 75atgggcatca taataatagc gcctgccaca ttgggtgagt gtgagaatga aggaattaat 60acatgtaaat cacttagact gtgtctggca tagaggacat tctaaagaaa agttagctat 120tatcattata ttattatatg ggtctggaat tagttcctga atccttctga gatgtgatga 180cttataaacg taggttgagt ttactcatga tagggtcatc gcaactatgc atagctaaaa 240tcaaattttg cttttcaagt ttgttttacc tggagcccta gagttcaggg ttatggttty 300ctttgtcact ccccttgagg gaagcttctt agtcacactc tccttctctt tctctgcact 360ctatgcactc tagaaaagct cctttttttt tttcttcatc caggcagaga ggcctactgg 420gacttaaatc caaggagctg aaatctgttt tgggatgggg tggagtcaca ttctggaacc 480tagacagaga atttctaagt tccagaaagt gctgcttact tcgcatttcc tctcccccac 540ctttgctttt gaaactcctg gcaccaatgc tgccaaggct ggcggagctt tcctgagtg 59976599DNAHomo sapiens 76actcacaaac aaacaaaagt attcccactc aggaaagaaa tcgtgtgttt gcctcaggcc 60aacttctgaa gtttctacca gctgcagttg ctgattctgg tatttatacc tgtattgtca 120gaaggtatta tgcagaaggc tcccatcttc tttcaccctg ctcccctttc ttcagtggtt 180gattgcctga gctgcccttg ctttcattcc ttccctagtc ctttctggaa cagttaaatt 240tataaaatga tttgaataaa agtgatttgg ataaacttct aggaatacta tcaggttgak 300gtctagctca ttctgagcta tttggattta cagttgcagg gattgatttg tagctgactt 360agagaaaaac ctagctttcc tagtgaccaa gataactgag agcaattgct tacttttggc 420tggaattaag aacaaactag cacagaaaat agtaatctgg atgttttcca tctcaggggg 480cctctagtag gtgaaaaggg gcttctaacc ttcaagttaa gccacagaag gctgatgaga 540ttgtgtgcct aaaaattaat tacttttgtt cacaaattgt taaatgtttt gattttgtg 59977599DNAHomo sapiens 77tatgcatttt acagagaagg aaactgaagg gcagagaagt aacttgctgg catcgcacag 60ttaactagtg gcagagcatg aatttgacac ttgtctagtc tcagacctag gcccttaact 120aatacatcct gctttttgat ttaattcatt tgacattttg tgtgtgccaa atacagccac 180aaaatcaaaa catttaacaa tttgtgaaca aaagtaatta atttttaggc acacaatctc 240atcagccttc tgtggcttaa cttgaaggtt agaagcccct tttcacctac tagaggcccm 300ctgagatgga aaacatccag attactattt tctgtgctag tttgttctta attccagcca 360aaagtaagca attgctctca gttatcttgg tcactaggaa agctaggttt ttctctaagt 420cagctacaaa tcaatccctg caactgtaaa tccaaatagc tcagaatgag ctagacctca 480acctgatagt attcctagaa gtttatccaa atcactttta ttcaaatcat tttataaatt 540taactgttcc agaaaggact agggaaggaa tgaaagcaag ggcagctcag gcaatcaac 59978599DNAHomo sapiens 78atgaagtgac ttactcaagg ccattgatga tgttgaaagt attgcaaaca aagattaaaa 60accactcgac aacatttatg tacaccatag tataccatca caaagcctct cattagactt 120tgaatccaat gagtattact aaagattaag ctctttttta atttgcagaa actctgacac 180caaactagaa aaaaaaaaaa aaagctggtt ttgctctcca aatagttgta ttgccattca 240aaaaaagtaa gttaagttag cattcagatt gctttatctt tggaaaatta agtcacaaar 300aaagaataaa gaacagatgt ggctttgaat tagtaatgta atttccccct gaaatttctt 360aaatcttgat agtgtgttca gaaaacctct ttgcgtcata gttcagaatg tataagataa 420gatggagcag gaggaagtaa agggaggagg gagaagtgca agaaacccaa ccagaagggc 480accgctgttc ccacttcgac ttctttcacg tagtattcta tctcattaat gtcagtagct 540tacccttgac cgtgaaggac ctggtcgccg tcacactata attggctcca ttttcattg 59979599DNAHomo sapiens 79ctccaatatt gctttgccct gaaaaaactg tcatacgtaa aggggctatt acatctacgt 60ctgtagatcg acttgtgcta aggagacccc aatcctttgt agattgataa gctatgattg 120tgaaatcttt cccttaaata agcttttata aaatttaaaa taacttggaa aacacatttt 180tagaatgaag tgacttactc aaggccattg atgatgttga aagtattgca aacaaagatt 240aaaaaccact cgacaacatt tatgtacacc atagtatacc atcacaaagc ctctcattar 300actttgaatc caatgagtat tactaaagat taagctcttt tttaatttgc agaaactctg 360acaccaaact agaaaaaaaa aaaaaaagct ggttttgctc tccaaatagt tgtattgcca 420ttcaaaaaaa gtaagttaag ttagcattca gattgcttta tctttggaaa attaagtcac 480aaaaaaagaa taaagaacag atgtggcttt gaattagtaa tgtaatttcc ccctgaaatt 540tcttaaatct tgatagtgtg ttcagaaaac ctctttgcgt catagttcag aatgtataa 59980599DNAHomo sapiens 80aagtaacagg ttgctttctt agtttcagca atgggctggc ttgtctagac atggttttaa 60gaatagctga cgtgaaggaa gaggatttat tgctgcagta cgactgtctg gccctgaatt 120tgcatggctt gagaaggcac accgtaagac taagtaggaa aaatccaagt aaggagtgtt 180tctgagactt tgatcacctg aactttctct agcaagtgta agcagaatgg agtgtggttc 240caagagatcc atcaagacaa tgggaatggc ctgtgccata aaatgtgctt ctcttcttcr 300ggatgttgtt tgctgtctga tctttgtaga ctgttcctgt ttgctgggag cttctctgct 360gcttaaattg ttcgtcctcc cccactccct cctatcgttg gtttgtctag aacactcagc 420tgcttctttg gtcatccttg ttttctaact ttatgaactc cctctgtgtc actgtatgtg 480aaaggaaatg caccaacaac cgtaaactga acgtgttctt ttgtgctctt ttataacttg 540cattacatgt tgtaagcatg gtccgttcta tacctttttc tggtcataat gaacactca 59981599DNAHomo sapiens 81agtgcctgcc tttgctttgc cttctgccat gagtaaagct cctgaggtgt ccccagaagc 60agatgccgcc atgcttccca tacagcctgc agaactgtga gccaattaaa cctcttttca 120tataaatcac ccagtctcag gtatttcttt atatcaatgc aagaatggcc taacaaatgt 180cttattataa agtagcacct aggattttct cactgaaatg gcagtagttt gatacttccc 240ctttttgttc actttaccac cctcgctaac aaaatgagtg ttcattatga ccagaaaaas 300gtatagaacg gaccatgctt acaacatgta atgcaagtta taaaagagca caaaagaaca 360cgttcagttt acggttgttg gtgcatttcc tttcacatac agtgacacag agggagttca 420taaagttaga aaacaaggat gaccaaagaa gcagctgagt gttctagaca aaccaacgat 480aggagggagt gggggaggac gaacaattta agcagcagag aagctcccag caaacaggaa 540cagtctacaa agatcagaca gcaaacaaca tcccgaagaa gagaagcaca ttttatggc 59982599DNAHomo sapiens 82ttctggtcat aatgaacact cattttgtta gcgagggtgg taaagtgaac aaaaagggga 60agtatcaaac tactgccatt tcagtgagaa aatcctaggt gctactttat aataagacat 120ttgttaggcc attcttgcat tgatataaag aaatacctga gactgggtga tttatatgaa 180aagaggttta attggctcac agttctgcag gctgtatggg aagcatggcg gcatctgctt 240ctggggacac ctcaggagct ttactcatgg cagaaggcaa agcaaaggca ggcacttcam 300acagtaaaag caggagcgag agagaggtgc cacactgaaa cagccagatc tcatgagaag 360tcactcacta ttgcaaggac agcatcaaag agatggtgct aaaccattca tgatgaactc 420acccccatga tccaatcacc tcccaccagg ctccacctcg aatactgggg attaccattc 480agcatgagat ttgggcagga acacagaccc aaaccatacc acacacatta tcattgttaa 540actttgtaaa gtatttaagg tacatggaac acacgggaag tctggtagct cagcccatt 59983599DNAHomo sapiens 83tcaatacttc aaagtaaaag acaaagaaag ttgaataact tgcgaaatac tacagttatg 60gagcaaggat tcaaacacag ccagcatttt cctagctata tgtgtataca gaaagtaatg 120ttttgtcatc acatacctga attacttata cttttataaa ataattcaca cttacgaaga 180cttcctctga tgtcttggat caacttcttt cctctacttg gaagcgtcca gccaatggca 240tggttacttc ccagcaatcc ccacaggaag tacacattcc tctgtgcatc cagctggggw 300ttttagagag agagtgacct ggaaaggaat cctgttgaaa tgatttactt acggagtttt 360cattatttaa cctgatgaca gtaagctctt tgtcaatttt cactttttcc ccccaatttt 420gtgtcacatc accttgataa ttcttgattc catactgctg gtcattgaga gaactgataa 480actattagag gttgtggagg aattcgtgaa tatgggccag tgatttttct accttaaaac 540tgggagccca tgcatggaga cttaagacgg aaaagaaccg tatcagcaaa tctcatttg 59984599DNAHomo sapiens 84agtgtatttt taatgctaat caatgtcctg gttatcatcc taaaaatgtt ctggattgag 60gccactctgc tctggagaga catagctaaa ccttacaaga ctaggaatgg taagtggcaa 120ataccaagtt tttctcccaa agaaaaagtc ccataataac tgttggttac ctgtctatta 180atctttcagt agctaggctg ctaagcccag attccatttt gcttgctaat ctgttatcag 240tgagttgtgt ttttggattt tcttaaaggc cattttccat cctgctatgt aaatcctcay 300ggtcctgaga tccatctcaa cagctcactt ttcttccccg ataggattgc tattcctact 360gagttcccaa taacagaatc tgccccaagc ccagaaaggt gtaaatttca taatgtatcg 420gtaagacatt atgaagttaa acacagtagc aaaattgttc ctgttttcca gatgtgagca 480ggttagaaag gtccatcgga atgcatgtgt gttctacctg aaaccctgat ctgtaaagtc 540taacccaggc acacaagcat gtgcatgaaa ggagtcagtt ctgcctgcta gatgcaaac 59985599DNAHomo sapiens 85gatgcaaact tcatgcttac atttggaggc agatacatgt tgcatttttc aaacagttga 60ctgaagtagg agctcattgt ttgatctgtg gaaaattcag atcccttaaa aaattctatg 120cccttgctac tattagcttt aaattttttc acttccccag gggagtatgg ggaaaccaaa 180gatgaaacca aagtctattc agcacagaag gcccccttag tcatagatta ttaatcaaaa 240ttgatgagat ggacaggttc ttgtccactt ttttgttatt tagtctgtga cagtaaaaas 300gagaaacact ttgggatgaa gactgttatt tcctgatagt gttttgtggc agtggtttga 360cgtcaacatc tcttgagtct agaatatttt ggaggatgac atacattcac caacagccat 420aaaacttgga gaggaatgtc ttcaaagagt ccagtgagaa tttttagaat caagtaagaa 480gttgtacttc ttgttttcat tttcagatgg aaagctctat gatgcttatg ttgtctaccc 540acggaactac aaatccagta cagatggggc cagtcgtgta gagcactttg ttcaccaga 59986599DNAHomo sapiens 86cacggaacta caaatccagt acagatgggg ccagtcgtgt agagcacttt gttcaccaga 60ttctgcctga tgttcttgaa aataaatgtg gctatacctt atgcatttat gggagagata 120tgctacctgg agaaggtaaa gctattgaca tacattaggg acagaaattc atgcttatta 180aaggctgtga actaggtggc cttatccctg cattggataa tgaattgcat ttactaccac 240aggccttaag accagaactt taaatattta tccagaagca gacacttatc cttcaatcgy 300ccctctccca tcattgtcct ggtgatgaga tcttcacagt aatgttggtg gtgtgaattc 360agagttagaa gtcctttgct tcaaggactt agcaaaccat catccctact ttattccctt 420ggtcccccac caggataact ctgccacttc ttaattctgt ccataagatt tgaaagagga 480cttaaaaatt gatgagtttt gttctggtag ccataggcac tagctgaaat accttaaaag 540tactcagaga gtcttcatga ctttctttat gttggtgaaa catttgcaaa tttatattc 59987599DNAHomo sapiens 87tggccttatc cctgcattgg ataatgaatt gcatttacta ccacaggcct taagaccaga 60actttaaata tttatccaga agcagacact tatccttcaa tcgcccctct cccatcattg 120tcctggtgat gagatcttca cagtaatgtt ggtggtgtga attcagagtt agaagtcctt 180tgcttcaagg acttagcaaa ccatcatccc tactttattc ccttggtccc ccaccaggat 240aactctgcca cttcttaatt ctgtccataa gatttgaaag aggacttaaa aattgatgar 300ttttgttctg gtagccatag gcactagctg aaatacctta aaagtactca gagagtcttc 360atgactttct ttatgttggt gaaacatttg caaatttata ttctcaccag aacaaaaaga 420actatagctt ctgttcctta atattcctac ccaattttat atacttttga cagttttatc 480acaactcctg tgtttgcagt agttattttt cccttccctt catacattta tgtccagtac 540ctgtggaccc tccttgtgaa ctcttctcta atttctcaca gaccaggaag ggtttggaa 59988599DNAHomo sapiens 88gtggagaggc aggtacatga ccaccctctg acctcctgcc agtgcctccc attggccaaa 60cccagcctgg agcagaggac aagggtgcaa tggattccat gatgatcagc cacccagggc 120cactggatgg aatggtggtg cagagaggat tttgatgggg caaatgcaag gtaagttgca 180tgagactata gacagtacct tagtcagtca tgaactttcc taagtgaaga gtgaagtttg 240gtgttgttgg gtttcattta ttttggttga ggaaaggtca gaggacatgc attgacagar 300ggaagtagaa aaccattcca gattagtatg ttgtcacaca ttgaaggcag cacaagcttg 360agtgtgagag agctagcatc tgggtttggc tgaggagaag tgtaactaga acttaggtgg 420atagactgaa aaagaagagg tgaagagctt gtggccagat gtggcacatt gttgagctca 480caaacaacag gagtccctgc aggttcttga gtacatttgt aatatgaaaa gagtgtttga 540gagcattact cattacttct acctgcatgg gtggccagtg ggaaaatggg ggaagaaga 59989599DNAHomo sapiens 89caaccaaaat aaatgaaacc caacaacacc aaacttcact cttcacttag gaaagttcat 60gactgactaa ggtactgtct atagtctcat gcaacttacc ttgcatttgc cccatcaaaa 120tcctctctgc accaccattc catccagtgg ccctgggtgg ctgatcatca tggaatccat 180tgcacccttg tcctctgctc caggctgggt ttggccaatg ggaggcactg gcaggaggtc 240agagggtggt catgtacctg cctctccacg tggggcttct ggagcagctg tgcttctccy 300tctgggagca cctcttctca gctggcctgc ctcatgcatc tgcaatccct cagacacccg 360tctgtgagaa tatcttggat tgttttattc acggttgtgc tttctcctgt tgcagtgagg 420actgggtatt tcatgttctt tctgagtcca cccagagcta attggaatca ccatggtgtc 480tacgctgtat aaatgccaaa tgggaaaggg gatctattgt cccttgagat ttttctagtt 540tggatcaaat cagtttctac aacagagatt aatgggggtg aagtaaagtc aggacttac 59990599DNAHomo sapiens 90cattgcaccc ttgtcctctg ctccaggctg ggtttggcca atgggaggca ctggcaggag 60gtcagagggt ggtcatgtac ctgcctctcc acgtggggct tctggagcag ctgtgcttct 120ccttctggga gcacctcttc tcagctggcc tgcctcatgc atctgcaatc cctcagacac 180ccgtctgtga gaatatcttg gattgtttta ttcacggttg tgctttctcc tgttgcagtg 240aggactgggt atttcatgtt ctttctgagt ccacccagag ctaattggaa tcaccatggy 300gtctacgctg tataaatgcc aaatgggaaa ggggatctat tgtcccttga gatttttcta 360gtttggatca aatcagtttc tacaacagag attaatgggg gtgaagtaaa gtcaggactt 420actttcctag agactttgga caattttgag gggcaaagct tcctgagttt gtgattttta 480atatgtgagt taaaatttta agccattgaa aaacatataa gcaaatattc taagaagata 540atatgtattc taagaagaat gaaccagaat tctaagtctc taatgcaaca atagactaa 59991599DNAHomo sapiens 91agacacccgt ctgtgagaat atcttggatt gttttattca cggttgtgct ttctcctgtt 60gcagtgagga ctgggtattt catgttcttt ctgagtccac ccagagctaa ttggaatcac 120catggtgtct acgctgtata aatgccaaat gggaaagggg atctattgtc ccttgagatt 180tttctagttt ggatcaaatc agtttctaca acagagatta atgggggtga agtaaagtca 240ggacttactt tcctagagac tttggacaat tttgaggggc aaagcttcct gagtttgtgm 300tttttaatat gtgagttaaa attttaagcc attgaaaaac atataagcaa atattctaag 360aagataatat gtattctaag aagaatgaac cagaattcta agtctctaat gcaacaatag 420actaaatatc tttacattcc catttacttg gaaggactct gttttagtta agactaagct 480acctgggaaa taaaaagagg acattggggc tgatattctc acaaatgaaa ggaacacaaa 540gaacaaaacg ggttctctat ccacacatac ttccacttct ctgagtaagt gacttgatg 59992599DNAHomo sapiens 92gactttggac aattttgagg ggcaaagctt cctgagtttg tgatttttaa tatgtgagtt 60aaaattttaa gccattgaaa aacatataag caaatattct aagaagataa tatgtattct 120aagaagaatg aaccagaatt ctaagtctct aatgcaacaa tagactaaat atctttacat 180tcccatttac ttggaaggac tctgttttag ttaagactaa gctacctggg aaataaaaag 240aggacattgg ggctgatatt ctcacaaatg aaaggaacac aaagaacaaa acgggttctm 300tatccacaca tacttccact tctctgagta agtgacttga tgtcagagaa tctcacacca 360gattataaca ataagacttt taaatgttca ggatgtttat gtttaaagca ttagactgat 420aagaaatctg atctatttct tgtatgacta gatgtagtca ctgcagtgga aaccaacata 480cgaaagagca ggcggcacat tttcatcctg acccctcaga tcactcacaa taaggagttt 540gcctacgagc aggaggttgc cctgcactgt gccctcatcc agaacgacgc caaggtgat 59993599DNAHomo sapiens 93tataagcaaa tattctaaga agataatatg tattctaaga agaatgaacc agaattctaa 60gtctctaatg caacaataga ctaaatatct ttacattccc atttacttgg aaggactctg 120ttttagttaa gactaagcta cctgggaaat aaaaagagga cattggggct gatattctca 180caaatgaaag gaacacaaag aacaaaacgg gttctctatc cacacatact tccacttctc 240tgagtaagtg acttgatgtc agagaatctc acaccagatt ataacaataa gacttttaar 300tgttcaggat gtttatgttt aaagcattag actgataaga aatctgatct atttcttgta 360tgactagatg tagtcactgc agtggaaacc aacatacgaa agagcaggcg gcacattttc 420atcctgaccc ctcagatcac tcacaataag gagtttgcct acgagcagga ggttgccctg 480cactgtgccc tcatccagaa cgacgccaag gtgatactta ttgagatgga ggctctgagc 540gagctggaca tgctgcaggc tgaggcgctt caggactccc tccagcatct tatgaaagt 59994599DNAHomo sapiens 94actaaatatc tttacattcc catttacttg gaaggactct gttttagtta agactaagct 60acctgggaaa taaaaagagg acattggggc tgatattctc acaaatgaaa ggaacacaaa 120gaacaaaacg ggttctctat ccacacatac ttccacttct ctgagtaagt gacttgatgt 180cagagaatct cacaccagat tataacaata agacttttaa atgttcagga tgtttatgtt 240taaagcatta gactgataag aaatctgatc tatttcttgt atgactagat gtagtcactr 300cagtggaaac caacatacga aagagcaggc ggcacatttt catcctgacc cctcagatca 360ctcacaataa ggagtttgcc tacgagcagg aggttgccct gcactgtgcc ctcatccaga 420acgacgccaa ggtgatactt attgagatgg aggctctgag cgagctggac atgctgcagg 480ctgaggcgct tcaggactcc ctccagcatc ttatgaaagt acaggggacc atcaagtgga 540gggaggacca cattgccaat aaaaggtccc tgaattctaa attctggaag cacgtgagg 59995599DNAHomo sapiens 95aataaaaaga ggacattggg gctgatattc tcacaaatga aaggaacaca aagaacaaaa 60cgggttctct atccacacat acttccactt ctctgagtaa gtgacttgat gtcagagaat 120ctcacaccag attataacaa taagactttt aaatgttcag gatgtttatg tttaaagcat 180tagactgata agaaatctga tctatttctt gtatgactag atgtagtcac tgcagtggaa 240accaacatac gaaagagcag gcggcacatt ttcatcctga cccctcagat cactcacaay 300aaggagtttg cctacgagca ggaggttgcc ctgcactgtg ccctcatcca gaacgacgcc 360aaggtgatac ttattgagat ggaggctctg agcgagctgg acatgctgca ggctgaggcg 420cttcaggact ccctccagca tcttatgaaa gtacagggga ccatcaagtg gagggaggac 480cacattgcca ataaaaggtc cctgaattct aaattctgga agcacgtgag gtaccaaatg 540cctgtgccaa gcaaaattcc cagaaaggcc tctagtttga ctcccttggc tgcccagaa 59996599DNAHomo sapiens 96caataagact tttaaatgtt caggatgttt atgtttaaag cattagactg ataagaaatc 60tgatctattt cttgtatgac tagatgtagt cactgcagtg gaaaccaaca tacgaaagag 120caggcggcac attttcatcc tgacccctca gatcactcac aataaggagt ttgcctacga 180gcaggaggtt gccctgcact gtgccctcat ccagaacgac gccaaggtga tacttattga 240gatggaggct ctgagcgagc tggacatgct gcaggctgag gcgcttcagg actccctccr 300gcatcttatg aaagtacagg ggaccatcaa gtggagggag gaccacattg ccaataaaag 360gtccctgaat tctaaattct ggaagcacgt gaggtaccaa atgcctgtgc caagcaaaat 420tcccagaaag gcctctagtt tgactccctt ggctgcccag aagcaatagt gcctgctgtg 480atgtgcaaag gcatctgagt ttgaagcttt cctgacttct cctagctggc ttatgcccct 540gcactgaagt gtgaggagca ggaatattaa agggattcag gcctcaggtt tcatctggt 59997599DNAHomo sapiens 97gtatgactag atgtagtcac tgcagtggaa accaacatac gaaagagcag gcggcacatt 60ttcatcctga cccctcagat cactcacaat aaggagtttg cctacgagca ggaggttgcc 120ctgcactgtg ccctcatcca gaacgacgcc aaggtgatac ttattgagat ggaggctctg 180agcgagctgg acatgctgca ggctgaggcg cttcaggact ccctccagca tcttatgaaa 240gtacagggga ccatcaagtg gagggaggac cacattgcca ataaaaggtc cctgaattcy 300aaattctgga agcacgtgag gtaccaaatg cctgtgccaa gcaaaattcc cagaaaggcc 360tctagtttga ctcccttggc tgcccagaag caatagtgcc tgctgtgatg tgcaaaggca 420tctgagtttg aagctttcct gacttctcct agctggctta tgcccctgca ctgaagtgtg 480aggagcagga atattaaagg gattcaggcc tcaggtttca tctggtaact ttccttccat 540ttccctgctt ctgggtggat gcaaaatggc cagaaatttt tctcctcaat cctccacca 59998599DNAHomo sapiens 98ccctcagatc actcacaata aggagtttgc ctacgagcag gaggttgccc tgcactgtgc 60cctcatccag aacgacgcca

aggtgatact tattgagatg gaggctctga gcgagctgga 120catgctgcag gctgaggcgc ttcaggactc cctccagcat cttatgaaag tacaggggac 180catcaagtgg agggaggacc acattgccaa taaaaggtcc ctgaattcta aattctggaa 240gcacgtgagg taccaaatgc ctgtgccaag caaaattccc agaaaggcct ctagtttgay 300tcccttggct gcccagaagc aatagtgcct gctgtgatgt gcaaaggcat ctgagtttga 360agctttcctg acttctccta gctggcttat gcccctgcac tgaagtgtga ggagcaggaa 420tattaaaggg attcaggcct caggtttcat ctggtaactt tccttccatt tccctgcttc 480tgggtggatg caaaatggcc agaaattttt ctcctcaatc ctccaccatc ctccagccac 540cattttcttc ccttttccct tttgcttgcc tgtcttcact gtggtgtggg atgttttca 59999599DNAHomo sapiens 99gatcactcac aataaggagt ttgcctacga gcaggaggtt gccctgcact gtgccctcat 60ccagaacgac gccaaggtga tacttattga gatggaggct ctgagcgagc tggacatgct 120gcaggctgag gcgcttcagg actccctcca gcatcttatg aaagtacagg ggaccatcaa 180gtggagggag gaccacattg ccaataaaag gtccctgaat tctaaattct ggaagcacgt 240gaggtaccaa atgcctgtgc caagcaaaat tcccagaaag gcctctagtt tgactcccty 300ggctgcccag aagcaatagt gcctgctgtg atgtgcaaag gcatctgagt ttgaagcttt 360cctgacttct cctagctggc ttatgcccct gcactgaagt gtgaggagca ggaatattaa 420agggattcag gcctcaggtt tcatctggta actttccttc catttccctg cttctgggtg 480gatgcaaaat ggccagaaat ttttctcctc aatcctccac catcctccag ccaccatttt 540cttccctttt cccttttgct tgcctgtctt cactgtggtg tgggatgttt tcactactc 599100599DNAHomo sapiens 100taggcatgtg ccatttgggg ctgttgcagt tggagagctt ccttgagaag gcaaatactg 60agccaagttg aaaggactct agggacctgg catctgggat aagtggggag ggtggcccag 120gtagcacagg cataggcaga tttgggggga agcataaggc taacaacaga cacttgtgtg 180acaaggacta tgaggtggca ttgattttct tggccttaca gatgagaagc cagattccac 240acaaattatt ttgtttgtta gagtttaagc gtgtgtgtgt gtgtgtatgt tatgccccam 300gatcattttc tcctctttgc atttggttgt tttatcatct cacaggctga gtaaaacgac 360tatgcatgga acactgtaga agaaaaatta tattaaaaaa aaactggtgt tatgattttc 420atccaggcat tttgtctcag gagttgctcg attgtatgtg ttgctaatga gtgatttata 480ttgaggcatc tacattgatt catgtgtgtc cttgtgaata gctgtaatct gaggctggcc 540atttcacttc ctcaaatctc aggttcctca ttagaaagag ctttgaaatg gctctttcc 599101599DNAHomo sapiens 101gaaggcaaat actgagccaa gttgaaagga ctctagggac ctggcatctg ggataagtgg 60ggagggtggc ccaggtagca caggcatagg cagatttggg gggaagcata aggctaacaa 120cagacacttg tgtgacaagg actatgaggt ggcattgatt ttcttggcct tacagatgag 180aagccagatt ccacacaaat tattttgttt gttagagttt aagcgtgtgt gtgtgtgtgt 240atgttatgcc ccaagatcat tttctcctct ttgcatttgg ttgttttatc atctcacagk 300ctgagtaaaa cgactatgca tggaacactg tagaagaaaa attatattaa aaaaaaactg 360gtgttatgat tttcatccag gcattttgtc tcaggagttg ctcgattgta tgtgttgcta 420atgagtgatt tatattgagg catctacatt gattcatgtg tgtccttgtg aatagctgta 480atctgaggct ggccatttca cttcctcaaa tctcaggttc ctcattagaa agagctttga 540aatggctctt tccctgtaca ttatgtgttt ctgtgaatta cttttagaga aaggtcagt 599102599DNAHomo sapiens 102taaaaaaaaa ctggtgttat gattttcatc caggcatttt gtctcaggag ttgctcgatt 60gtatgtgttg ctaatgagtg atttatattg aggcatctac attgattcat gtgtgtcctt 120gtgaatagct gtaatctgag gctggccatt tcacttcctc aaatctcagg ttcctcatta 180gaaagagctt tgaaatggct ctttccctgt acattatgtg tttctgtgaa ttacttttag 240agaaaggtca gtttctcagg gtgggaccca taaacaaggg caactgggca gagccagggr 300ttcaggtgac tgtttggacc ctctggaagg gctttttact gtgctgcctt gggagacaga 360gtggtcagct tggaactgac cttaagccta ggtcacccaa tttttgaagg aaactttttt 420ttttcattta gagaaaactt catgcctttg ggtgattagg taagtttgtg actattcgtt 480atgtgtgtgt acacacacgt acgtacatat gtacatgcac aaatatttaa tatgtcttag 540acacaccaaa tatatgcatt taagatgtat taaatgtact ttcctgagaa tacaaataa 599103599DNAHomo sapiens 103ctacatcaat ataaaatttg tcatatatta gcataacaaa agagagaaag taaacaacaa 60gttagacaaa catctgagaa ctggacaaaa gacataaaga gatggttcat aaacatgaaa 120ataaaatggc tgataataag tgattaatat ttgcctcatt tatacccaaa gaaatgcaaa 180ttcagaaaac aatgagatac catttttcca ttttggctgt ctaattacat tttaaaagta 240aagctgctca gtgtgcttct gggtgtggtc gatagatgct gtcttgtgct attgagtgar 300agaatatgaa tattgcaaca cttctggaat gcagtttgtc agcatgcatc tgtcaggttt 360caatgtagtc ttcaactcaa tcactgtact gccatcgagt aacatccagg aaataataag 420aaatgtagac aaataataat agctaacatt taagcggtat taccattcac cagacacttg 480caatagtaac tcatttaact ttcacatcag ttccaggaga tggtattatt atccccttct 540atagataaga aaattgaggc acagaacagg caagtcagtt gcccacagtc ggttagctg 599104599DNAHomo sapiens 104aataaacaat ctgtgacatg ctgagctatg tatggcagtt ctgcccatgt aacagagtgt 60gtgtgtgtgt tttcacatca aaacattcct gaattgtaat gagatcttca tttagggttg 120aatttttaaa actccatctt cctccttcag aacgtaggtt tcataattct ttcataattc 180taggcactaa gtctattttg ctcttcactg tatcactaaa atccagcacg atgcctagca 240catggccagc actcactaac atgtgtcact gaggcatagg tgtgtatgca tgtgttcgcr 300tgtgtctgtg gctgcccata tgagtttact ttagggaaat ggagagatga agtgacagtc 360tcctacactc cagacccctc ctttacattg actgtgtccc agtggaacta agatctgcat 420tgaactttga tcctactgca acctagcatt cggagttctg attacaactt tgagcccagt 480ggaggaagga tcccccacag tggagaccat tcagagtcta aatactgcat aaacaacacc 540atatcccttg tttaccatcc tgagtgcagg gagcacagcc tgatggcaga gtctggttt 599105599DNAHomo sapiens 105ctgctctcac tacatgaact cagactgcag aatcttttct tttctgaata aattcagcat 60cttcagtagc caccacataa aaaaaaaaac tttgacattc ttcctcaatt actcatgaaa 120tatgtttgag agtatgtata atcacttacc tgcagtgctt acagatataa gcacccaaag 180ggtcaagggt aattctctac aattcatggt ttggattctg cttcaaatgg cttctctgga 240aaacagaata aaacagattc agccaaagct ttcaaacaaa agtgtgccta tcttatgaar 300gtttaaaaat cttctggcac acagattttt aaaaaaacaa cctagaagat ttttataatc 360cttaatatag taaccaattc tcagaacttt cagccatata aaattaataa aatttcaagg 420caatgaagtt tttcttctgg aagaaatccc taataattta tttctctgat acaacagagt 480ctgaagaatt tcaggcctgg tctactaaat cctgcttcca aggccaaagt tcagaacaat 540agtactgcta caaatattac cattctatga ataaacaatc tgtgacatgc tgagctatg 599106599DNAHomo sapiens 106atgccaccca ggaagctgac actgccccat tcgcaacaca ttaatattat cgtgaagtcc 60gagctgctga tttcatttga ctgggggcat gtagacaaca ggagcagctg aattttaaaa 120ctgactttca tgcaatcgtc acttgtcatt ggtaaggatc ccctaaaagg aaatcctatc 180aaagtaatct cctttcatta aggtcactaa gaaaataagc agagagagat aaacttattc 240tgttccataa caaagaatgt atttcatgtc ataggaagag taggaaagaa aaggatgtgs 300tgattatctg acctttcaga ttactgcata tttgagttgc tgaacaaagg acaagagggc 360tgtgaaatac attttgaaaa gaaagggtta ctcacttcat ttggaaaaag taagatcctg 420tgtcattcaa ctcaactggc caaaactcca aaacacaatc atgcaaagca attctcgagg 480aactccttgg gttcagctcc acatgttcct gtgatccact gcttttgtac cagcttttgg 540tggttgtttc aatctcatgt gcaagtgaac acgagcaatg tttcagatag aaaggttcc 599107599DNAHomo sapiens 107atactgctta ctaattatgc tatatttgaa tatgtctgta tcttctatgc tcctgggtgt 60ctaaaacaac ctgcttccat gtagaatccc atttattttc aaggccattg tcaaagctgc 120ttctctcctc aacactttac tctcatagtg atcagtctcc aatatccact ctgggacacc 180tcatttttct tagcatctcc tatctgctac cctgtctctc cacacctctc tctgacatcc 240tgcctcaatc tcttgcttcc attgttgctt cctaagccag gctgtattct ctactacccr 300tatcagaaag atggccaatg ccatttgctt ctgttatctc caagtgatga tcatagatgc 360ctggctgttc ctctcaacgt gctctctcag gcctgtccag aatactttat tcctttaaat 420tgtgccttca ttcaatcagg agttggaagt ttgtggtggg gggggcggtg tttgttgttc 480tttttccttt accccatttg tgagtattca ttcttcctta gcttgttatg aaaaatccca 540gttgtgaccc atttctgtaa ttatcactct taaaaggtca tctaaagatg tactgattt 599108599DNAHomo sapiens 108ctaaaaatta aagaattact gttctaacgg gaaattttca ggtgtaaagt ctgttcactg 60atagatccca catcaaactg caaagggtta cacacctaag ttagaacaca tatgtgtata 120cacacacatc tgcagtaaat actgcttact aattatgcta tatttgaata tgtctgtatc 180ttctatgctc ctgggtgtct aaaacaacct gcttccatgt agaatcccat ttattttcaa 240ggccattgtc aaagctgctt ctctcctcaa cactttactc tcatagtgat cagtctccar 300tatccactct gggacacctc atttttctta gcatctccta tctgctaccc tgtctctcca 360cacctctctc tgacatcctg cctcaatctc ttgcttccat tgttgcttcc taagccaggc 420tgtattctct actacccgta tcagaaagat ggccaatgcc atttgcttct gttatctcca 480agtgatgatc atagatgcct ggctgttcct ctcaacgtgc tctctcaggc ctgtccagaa 540tactttattc ctttaaattg tgccttcatt caatcaggag ttggaagttt gtggtgggg 599109599DNAHomo sapiens 109tcagcctagg attggtttat tagatttctg tgtgtacatt tccctctacc ttcatttctt 60catctctatc attgaaaact atcccttttg tatccccttc cttcttagtt gatttcgttc 120ttaaaatttg gtgggataaa gtgattttca ctgcaggatt aaattatcag tcctcagtgg 180catttgatta ttagcaatgt actcctaaaa attaaagaat tactgttcta acgggaaatt 240ttcaggtgta aagtctgttc actgatagat cccacatcaa actgcaaagg gttacacacy 300taagttagaa cacatatgtg tatacacaca catctgcagt aaatactgct tactaattat 360gctatatttg aatatgtctg tatcttctat gctcctgggt gtctaaaaca acctgcttcc 420atgtagaatc ccatttattt tcaaggccat tgtcaaagct gcttctctcc tcaacacttt 480actctcatag tgatcagtct ccaatatcca ctctgggaca cctcattttt cttagcatct 540cctatctgct accctgtctc tccacacctc tctctgacat cctgcctcaa tctcttgct 599110599DNAHomo sapiens 110acagacacca ggggataaac accagccccc acttctgagg ctgctcacca agctgaactt 60gctgcctgtc agcctaggat tggtttatta gatttctgtg tgtacatttc cctctacctt 120catttcttca tctctatcat tgaaaactat cccttttgta tccccttcct tcttagttga 180tttcgttctt aaaatttggt gggataaagt gattttcact gcaggattaa attatcagtc 240ctcagtggca tttgattatt agcaatgtac tcctaaaaat taaagaatta ctgttctaay 300gggaaatttt caggtgtaaa gtctgttcac tgatagatcc cacatcaaac tgcaaagggt 360tacacaccta agttagaaca catatgtgta tacacacaca tctgcagtaa atactgctta 420ctaattatgc tatatttgaa tatgtctgta tcttctatgc tcctgggtgt ctaaaacaac 480ctgcttccat gtagaatccc atttattttc aaggccattg tcaaagctgc ttctctcctc 540aacactttac tctcatagtg atcagtctcc aatatccact ctgggacacc tcatttttc 599111599DNAHomo sapiens 111ggaacactga aacaatcaac aacacactgc acctgccatc caggagctcc aaggctaggg 60ttaacactga ggccaactga cccaaagctg tgaccacact ttcctgctgc aggcccagcc 120catcctggtt atgaaaacca ctcatttttg tccacagaca ccaggggata aacaccagcc 180cccacttctg aggctgctca ccaagctgaa cttgctgcct gtcagcctag gattggttta 240ttagatttct gtgtgtacat ttccctctac cttcatttct tcatctctat cattgaaaay 300tatccctttt gtatcccctt ccttcttagt tgatttcgtt cttaaaattt ggtgggataa 360agtgattttc actgcaggat taaattatca gtcctcagtg gcatttgatt attagcaatg 420tactcctaaa aattaaagaa ttactgttct aacgggaaat tttcaggtgt aaagtctgtt 480cactgataga tcccacatca aactgcaaag ggttacacac ctaagttaga acacatatgt 540gtatacacac acatctgcag taaatactgc ttactaatta tgctatattt gaatatgtc 599112599DNAHomo sapiens 112gtaataacaa tagaaataaa gtgcacaata aatgtaatgc gcctgaatca tccccaaacc 60aaccattccc cgctcaaccc ctgcccaccc tggtccatgg aaaagttgtc attcatgaaa 120tcagtctctg tgtcaaaacg gttggggaca gctgatgtag tttatatgga ataacaaatc 180tgaataatat gactctgtcg tggaaacttt aaagacctat aagagagtgg tctgaacaga 240acttgggaaa tctgaagcga gtgatgataa tatccttgaa atttttgttt gtgccttatk 300cttgaacact gtttacttgt gatttccaaa gacagctctt atctgaaatg ttttctaaac 360actcgaatca gtcctgagtt gactttattc tatttcccat caatgtacaa atgtgttaca 420gtatatgtaa attagtgagg cttggtgtgc tgagttttaa gaaattccgt tcgggtgcag 480tggctcacac ctgtaatccc agcactttgt gaggctgagg tgggcggatt attaggtcag 540gtgatcgaga ccatgctggc taatatgatg aaaccccgtc tctactaaaa atacaaaaa 599113599DNAHomo sapiens 113ctactaaaaa tacaaaaaat tagctgggtg tggtggcaca tgcctgtagt cccaactgct 60cgggaggctg aggaaggaga atcacttgaa cccgggaggc agaggttgca gcgagccgag 120actgggccac tgcactccag cctaggggag agagcgatac tccgtctcaa aaaaaaaaaa 180atgaaattcc aaagtgcagc tatttaaatt atgagcattg gtgcaccaag gatatttagc 240taaacaattg accacagggc taagtattct aagcctgttg actgatcatg acttcacccr 300agagcaagga ggctaattca gtagataatt gattggaaag gaaaatgaag agtctctgat 360cttttctata gcttgaaaaa attagtttgg ctttataaaa ttttgactta tacataaata 420atttactgac gtgaggtaca catgtgggtg cttcacgggc acattctatg cacaatgggt 480ctagccccag tggctgccag ctctgaggga gaagtctgtg ggcagtaggt tctccttgct 540tggtgtttgc agaaacagtg tccaatggtc aaggatggcc attcagcccc cagacatcc 599114599DNAHomo sapiens 114taatggatat tcctacagct tcatcaaaga aggaaggaaa gagctgctga tgggcagaaa 60gcaaagatgg tgggaaagag ggtgtaggtt ctgaaagtat caaagtaaca gagatttata 120tgagattaaa aatagatgta ggaaagtaaa gttggagagt ttagggtaga tgattataca 180cagaatttaa gtttttgagt ttaaaattca gttatgggtt tcccaggttc tgggctgtgg 240caggcagaat aatagaccct gaagtttccc acatcctact cctgagttcc tgtgaatacr 300atatgttaca tggcaaaagg aacctctagg tgtgattaaa ttaaggatct tgagataggg 360ggatcaccct ggattatcta ggtgggcaca atgctgtctc aaggtcctca tcagagggag 420acagaaaggt cagagtcaaa aaggagatga ggtgagggaa gcaaatgtgt ttggctctga 480aatgaagtgg cacaagccaa gaaatgcaag tggtctctag aagctggaga aagcaaaggc 540aaagaaacac attttccagc ctggtgcagt ggcttatgcc tgtaatccca gtactttgg 599115599DNAHomo sapiens 115agcagctctt tccttccttc tttgatgaag ctgtaggaat atccattatt aaaagggtgc 60ttgttatggg ccagggatag tgccaagtac tggagttgaa tcatgtcata taatcctcac 120aacagctctg tgagactgtg gccttgggtg agttaatttc cttagttcct ctctgcctca 180gattcctcat catgaaatgg gacagtaatg gttcatccct cgtagggttg gctgacaatg 240actgagtgag tgtgtgtaca gctctaggat ggctctaggg acagtaagag ttctgctgtr 300atgaccatct cccactgcta ggttcccaaa cctcacctgc agcacaagct attcttctcc 360cataattgtc catcttattt ttcttgtctt cttggagaat gtcaactgag tctctcagga 420ctccactcaa atgtcgctcc tccttcatgc ccccatggcc tcttgtttgt atttctgatt 480gctgtcagaa ttgcaataca tgtgtgtctc tgtcaataac ttgaaaggtt tctggaaagg 540tttgcactga cttctgttcc tcatctttgc atcttggata cctacaattg gcacttggc 599116599DNAHomo sapiens 116gtggcaaact ttgccaaatc caaagaaaaa tagccaggat ggtgaagtgt ctagacttct 60tgttgtatgt ggcatcaaag gagttgtttc tgtctcagtg atgcacacaa caggcatgta 120atgagcacct ttatgtgcca agtgccaatt gtaggtatcc aagatgcaaa gatgaggaac 180agaagtcagt gcaaaccttt ccagaaacct ttcaagttat tgacagagac acacatgtat 240tgcaattctg acagcaatca gaaatacaaa caagaggcca tgggggcatg aaggaggagy 300gacatttgag tggagtcctg agagactcag ttgacattct ccaagaagac aagaaaaata 360agatggacaa ttatgggaga agaatagctt gtgctgcagg tgaggtttgg gaacctagca 420gtgggagatg gtcattacag cagaactctt actgtcccta gagccatcct agagctgtac 480acacactcac tcagtcattg tcagccaacc ctacgaggga tgaaccatta ctgtcccatt 540tcatgatgag gaatctgagg cagagaggaa ctaaggaaat taactcaccc aaggccaca 599117599DNAHomo sapiens 117gctaatggac tgagtgggga aacccagcaa gacctgtcca gattcttctt ggcctctctg 60ttatatttcc ttttcctggg tagagggcag agggtcttaa gacttactgt cagaccaaag 120aaggccaaag aatttatagc caactcctag acagaaaggc aggagaaggt tagagtcatg 180cttctaggtt ctatggctta ctttggggaa aaggattcta gtttttatga tctgcctttg 240ggaagaggga gtctggtttc tgtgacttgc tttggggaga atggaggcat gaagcaggar 300ggtcagagag atcttgcttt ttgaggctgc tttgaggcct tccaatgtcg ttgagtttaa 360agtactcagc ctgccaaaac accatacttt gggactgttt ttggagccca ggagttccat 420tgccttcagc ttgtgctcgt gaatcacagt cacctgaatt cctactgggc atctgccact 480ttcctggtct tatgctctgg ctgatcgggt ggcgtctcct cctactgctg acaacctcta 540tgccattttg actctgatag cctcctaggt aggctggcca tgtcaagggc atgcactaa 599118599DNAHomo sapiens 118cctactgggc atctgccact ttcctggtct tatgctctgg ctgatcgggt ggcgtctcct 60cctactgctg acaacctcta tgccattttg actctgatag cctcctaggt aggctggcca 120tgtcaagggc atgcactaag atgttgtctt ccttccatga cctacatggg actgcaccct 180tcactttaca ccagttgtgc aaactcaggg ctgatctgga tttccaatga tataatttga 240gtgttagtag acagcatcct ttgctgaaga tgtacttcac actgcccctt ctcaagtcty 300ccatgtaagt ttctggggga aaaaatggat ccagagaaag gtagtcagta gcagttttcc 360ccctcacacc gaaattgcct cctgcccttt gtctttgaat tcaagccggt gttgcttctt 420actgtcagac ctgagagtta gttctttccc tggatacatc tcagctcctc ctgcctgttt 480gccaacattc caggcttgcc cagagactcc aaatcccagg ataacccaga cctgactctg 540aactccggag tccactgtgc tggtttcatt ctcctgttct tgctcacata tctgcccac 599119599DNAHomo sapiens 119gtatttttag tagagatggg gtttcaccgt gctggtcagg ttggtctcaa actcctgacc 60tcaagtgatt cacctgcctc ggcctcccaa agtgctggga ttacaggcgt gagccaccat 120gcccggccta aattttcata tttagaaatg accatagaga gagttaaaga caagccacac 180acagcacaac aaaaacctta gtctacagac cacaggcagt tccactgtct cttgaacttt 240aaaatgttgc cacttttaag tcaggttaaa agtggcaaca ttcaaaaaat ggcactctty 300tcttagtttt gtaatgttat tcagtaaata tgaaatgtgt atccagtgtc attcaataat 360gaatcatatt tacgcttgga aggctctatt atgtccccta cttataaatg cagaatatat 420gtatattgaa atatacctaa ttccactgca acatggttaa gctttggtcc aagaagaacc 480ggaactatat tactgcgatc tagaagtgac aaaagaaaag acaaatgtat tagtgttgcc 540ttgagcttct ttatgacaag catctatgat aatatgctca tttcatgtaa caaagattc 599120599DNAHomo sapiens 120acttaaggcc cacagtatgg tatatcttgc tgaatgttcc aagtgcattt gaaacaaagg 60tatattctat aggtttttgt tttattattc tttaaatgtc tatttggtta agttcattaa 120tggtgttgtt caaaaaattt atatcctgac taatctttta tctgcttgtt ccatgtgttg 180ctgaaagaga tgtgaatatc tccagctatt atggtcaatg tgtctctatc tcctttagtt 240ctgtcaattt ttgtcttaca tagtttggag ctatcttata tgcatacacg gatttatgcy 300cgttgaatta acacttttat cattatgaaa tatctctctt tatctatcat aacacttcct 360ctctcaatgt gtagctctgt catatgaaat aatcacacaa gttttctttt gcttggaatt 420ggcatatttg tcttttttta aacatccctt tactactaac attttttttt gttctataca 480taagtgtctc tcataaactg catgtatttg ggtctttttt gaaatatggt cagtatggtg 540tttagtccat ctgtatattt aaaattactg ttacagttgc tatatcatat atgcatgat 599121599DNAHomo sapiens 121taaataccct caatggcctt ctcatggacc ttcttttcca gcttagatct tggcaataca 60tttctgcata atgcgtccac ctagggtatg gccactataa ttataaaata tgtccattat 120aattataatt taaactagcc caaaatacac atcagccacc cagtgttttt aatatgatgt 180tatatataat atatatgatt gttatatggt atatatcatg acatatatat tacacataca 240tacataattc tcatttcttt ctcttcatgt atattaggat ccgatccatt ttcttccccr 300aacatccaat aaattacatc ctcttcattc agcaaagcag agcagttgag ccttacgttt 360tttcctggta aaagttggca actaaagttc tgatttttga aactcaggtt tcttaaaagt 420ttcaaaacaa tataatcaat gtatgttaac ctaaagcaaa acgtggtgct ccatcccaga 480aagagaataa atatgccttg ctttaaataa aacaaaatat ataaagcaga agaaataggt 540agcaattaca agtcatcatc aaaacatgat ttggcttctt tttaaacatt tatttttta 599122599DNAHomo sapiens 122ggagctgggt tctggtgtgg aaaatgagaa agtggccatc

tttgaaatgt ctctcagtag 60caatgagcta agtttcaaaa cttccaaaaa taaatctttc tcaccttttc tcaccaagat 120gaagcttttg gtgtctgtgc ctcccgtgct ggccacagtg caattatata aaacatttag 180attgctttca ccaatatttt caattctcaa tacttttgaa gcatgccatt tgccttctgg 240agtcctgtaa gagggcaaaa taatttagca gtaggctctg ttcgttaccc ttgagagggk 300aattcacatg tttaaaatgc ttgaaggcag ctgtgatgtt gcctgcatta tttcttccct 360ttctggccag tactcttaaa gcatggacta caataaacgt cccctcctcc gtggagcatc 420agaactgaca gaaacagccc tcctgaggcc atttgggaat ggtgctgtca attacctgaa 480gtttaaatgg ctggaagatc atgatgctaa gttgaaaata taagaaaata ttctctctca 540attatttttc tctacttctc tcttcctaac aacttggggt tctttccaca gagtggttc 599123599DNAHomo sapiens 123aaaaattact ttattctttt tattcctctg tattatctca gattgtccat aataaacata 60aacggaatca atctagaaaa tgtatttttt tccaaatgat acttttatac aaagaatttg 120ctaaaattcc aagagctgtg tgctgtatta actacttttt gtgtaatatt tcatttaatc 180ttccccaaag gagcagcctt gtaagtgaag cagttagtat cttcatttta cagatgaagg 240taccaaggtt taagggcatt cacgattttt cctacaatac aaaataattg atggagcccr 300gctgcaaacc cagacaaatg tcaatccagt gctctctctc ttctctcaaa actatgcacc 360tcaacccact tgctaatatt tctgtgagtc cctatgtgtt tcagcctagt atctcttcac 420cccagaaatc tgatttccac gggtacggat agaatacatt actgtgtaat gttttcactt 480cagttctcta aatatccgtg tacacatttt tattctttaa aaatctgagt agaaatatca 540ctactccaga ctaaaggcag gaatgtggag tcactcagtg gaatgtgtca gcacgtggg 599124599DNAHomo sapiens 124ataattgatg gagcccagct gcaaacccag acaaatgtca atccagtgct ctctctcttc 60tctcaaaact atgcacctca acccacttgc taatatttct gtgagtccct atgtgtttca 120gcctagtatc tcttcacccc agaaatctga tttccacggg tacggataga atacattact 180gtgtaatgtt ttcacttcag ttctctaaat atccgtgtac acatttttat tctttaaaaa 240tctgagtaga aatatcacta ctccagacta aaggcaggaa tgtggagtca ctcagtggar 300tgtgtcagca cgtgggttgg caactactgc attagtgtta gcagtaaaaa tggacaagca 360cgtgatgatg gacaacactg gtaagatttc ttgattattt tcttttcctt tttccctttc 420ttttctagca gacatggctg atatcccagg ccacgtcttc acaagaggaa tgatcatagc 480tgttttgatc ttggtggcag tagtgtgcct agtgactgtg tgtgtcattt atagagttga 540cttggttcta ttttatagac atttaacgag aagagatgaa acattaacag gtaacacat 599125599DNAHomo sapiens 125ctcaaaacta tgcacctcaa cccacttgct aatatttctg tgagtcccta tgtgtttcag 60cctagtatct cttcacccca gaaatctgat ttccacgggt acggatagaa tacattactg 120tgtaatgttt tcacttcagt tctctaaata tccgtgtaca catttttatt ctttaaaaat 180ctgagtagaa atatcactac tccagactaa aggcaggaat gtggagtcac tcagtggaat 240gtgtcagcac gtgggttggc aactactgca ttagtgttag cagtaaaaat ggacaagcay 300gtgatgatgg acaacactgg taagatttct tgattatttt cttttccttt ttccctttct 360tttctagcag acatggctga tatcccaggc cacgtcttca caagaggaat gatcatagct 420gttttgatct tggtggcagt agtgtgccta gtgactgtgt gtgtcattta tagagttgac 480ttggttctat tttatagaca tttaacgaga agagatgaaa cattaacagg taacacatat 540aatgctggaa tttcttacct tatgttctca ttaagaaatc agataaatag gcattaatc 599126599DNAHomo sapiens 126ttgtcactgt gtcagtgaca aaacaggcat caacatgtaa gacaattaaa tgagcacact 60tttttaaagg gcataatttt cttatgatgt aatggattgc aacaaactgg gaagacgatt 120tcatcaaata tgggtttata ttacatacaa tatagctttg ctcttaccta tgaaaaatta 180gcttttcaac tattaattgc tttcaaattc cttattttaa gcaattcttt taatataaat 240atgctaattt tattacaata tattttaaat tcaggtttta aaaggtttag gggacttgas 300aattgacaga gtaaagtatt caaaaaaagg aatttgaaaa ctaatggtaa tgtttttatt 360ctctatattc aaacataaag gaaaattata aaggaaatta taattcaagt ggatatttgg 420gacttcaagg agtaagttaa acaaatgttc ctcaaactat gcttggtgaa tgaccatgtt 480ttaatttaaa tttgcctttt tttgttgttg tttattgatt agtttcattt ccaatccttc 540agaaaccaat actgaacact ttcttagata ttgcagcagt attaaattgt gataaaagt 599127599DNAHomo sapiens 127atatccactt gaattataat ttcctttata attttccttt atgtttgaat atagagaata 60aaaacattac cattagtttt caaattcctt tttttgaata ctttactctg tcaattctca 120agtcccctaa accttttaaa acctgaattt aaaatatatt gtaataaaat tagcatattt 180atattaaaag aattgcttaa aataaggaat ttgaaagcaa ttaatagttg aaaagctaat 240ttttcatagg taagagcaaa gctatattgt atgtaatata aacccatatt tgatgaaaty 300gtcttcccag tttgttgcaa tccattacat cataagaaaa ttatgccctt taaaaaagtg 360tgctcattta attgtcttac atgttgatgc ctgttttgtc actgacacag tgacaaccct 420agtggaagca ctagctctta cttaactagt agatagttat atttgatagc agtttaagaa 480aagtttgagg gggaacctac ttactgattg ataactggtt ttatttttac caacatttca 540tacctttgat atttatgtaa gcctgaaatt tttaccaaca tttttcatct ttcaatgca 599128599DNAHomo sapiens 128aattttattt aagtacaaac ttaagtgaat gtcgtaagta atgagtatag aatcattgaa 60aaaacaaatt atatataaag ttgtttatat ttaaacctcc catgctaacc aagcaaccaa 120ttagccaatg tgtttttaag catctacttt aagatcccac tgcttgacac cacagaagaa 180tacagagata tatgagccat agatctgggc actaaaggaa cttaagtctt taagttcctt 240agaaggccaa gagcccaaag gtgtcctcat tccaggagtg gaaagaaaat ctcaccctgk 300tttactcata tcatttaatt ctaccaccat cacaatttct atgctcagaa agacccccaa 360gaaggtgaaa atgtctccta aataacaaag accatgctcc taattgggta attaaaacat 420gataccactc tctcttctag cttcatccaa tctattttta aaagcaaagc agatgcatgc 480aacaacttgg aaaaagttac agacaacaca ttagcagaag aaaaatagca taacaaaaaa 540agaataacaa aactcacaga caaaataacc tggccagaga ataaagagtg atcccgatg 599129599DNAHomo sapiens 129caataaaaac ccatgcattt tctagtaata attaacccgt gtttatttct agtaagagtt 60actagtgagg attaactagt ccacacatca catgttaaat taggaactgc tgctgtggta 120cagatattct caccgtgggt catttctaaa taaaggcttc atgataacgc cagctctggg 180cccggttctg aaaaggaaat gccctctccc tttccccaaa gtttcagaga accgtgaagc 240acaaagaaca gagcccaaga gaagagacta ttggaagctc attagtttgt tttctcactr 300tcgattgttg acttacgtgg ttatttcttg cttaaaggac cttattcatt tgtttttaag 360gaaaatggga tagctctctg ggggctagct cattcatttt ttaaaaagaa actatcttga 420atatttttct atctggcatt ccctcttacc tcctccaggc actacatccc tttcaaatat 480gcataactta tacccaaaat gtttctccaa caccctgggc aaaatctcca cagcaaaggt 540gtgctcctct ccattttcag gtcggcattc ttttaggtaa gacacaaaag catcatatg 599130599DNAHomo sapiens 130taatgagctt ccaatagtct cttctcttgg gctctgttct ttgtgcttca cggttctctg 60aaactttggg gaaagggaga gggcatttcc ttttcagaac cgggcccaga gctggcgtta 120tcatgaagcc tttatttaga aatgacccac ggtgagaata tctgtaccac agcagcagtt 180cctaatttaa catgtgatgt gtggactagt taatcctcac tagtaactct tactagaaat 240aaacacgggt taattattac tagaaaatgc atgggttttt attgtgttga tattggtgay 300gaaatttaag tagaaaatag gaaaattgaa aagggaaaaa taacaggaaa gcggtgatcc 360ccatcagatc atagctatga aattcaatgt tttttttatt aatataggaa tacaaatggc 420catagtgcct atattaaagc aaattactgt taaatttttc tttttaatga gtaacatttt 480tagattttct ctgaagtctt tagaacaaac atttaaaatc tggtgtcaaa ttattctgga 540tactgatgct taaaaaaaaa aaacaaatgt ttgattatta ccatcattca tgtattaat 599131599DNAHomo sapiens 131aggaccccag aatagctctt tatctttcac aagagacaca aattctaatt gagttaatta 60tctgggcctt tcactttgga tgctctgaaa catttgttga ttttgtgtga atgtttatat 120caaaatgttt gccaggttgt attagccatt gaatagcaaa aaactgatag ttacttgctt 180gttttttaaa aattacatat taaaaatgcc cttggcataa ggcagcatgg tgtggcagtt 240aagagatggg ctgtgcagcc catcctgagc tccagtcctg agtttgctac ttacttctgk 300ggcctctgga accttatcca acctcttggt gcttcagttt cctcatctgt gaaattagaa 360tttataataa ttgcacctac ctcccagggg taactaaatg aataaatata ataaagtact 420tacagtggtt cctgacacag actcagcact ccgtcagtgt tgccatgact atttttatta 480tcattattaa tgattactta gatcaattat ttagcagtgg actaatggaa gctacagagc 540agggaaggga agcagatcta gggaggaagg cagttttgat ttgaggaggt ttgcacatg 599132599DNAHomo sapiens 132agccagtcct agacagcccg cttcccctcc gcaggcccct gccctaggcc ctcttagcct 60aaattgtcgg ccccagaaaa gtgcctgcag cctccaagat gctcatctcc aagaggaggc 120cgtacgccat cctgtgccaa cctggtcaga ccgctcgtgt gcaactgtga ccaagtccct 180ggacttacca tgcctcaagt tcctgggttt ggaatacgtg gggcctaagg cttctcactg 240ctttgagaag atatagctct aatgagtaaa tgcttctagg acatgacaga catgtaagar 300gtgtttcttc acgtgcccta gaaaggtagt tgtgctgatt ctctaaaata gacttcacag 360tttaagggca tctgaaccat ggaaaagaaa gctgttttat acctgaaaag ttatttgttg 420gtcctggttg gggaatgttt aaaccagaat tttaaaatat gcccattaat taactgacat 480atgaagactt accatgtata agtccctgtg tttagtattg agtggcttgt gagaaacaga 540agagaattag tttgctcctg gatggaaggt gtgaaacaag aaggtaggtg caaggcaat 599133599DNAHomo sapiens 133cccttaaact gtgaagtcta ttttagagaa tcagcacaac tacctttcta gggcacgtga 60agaaacacct cttacatgtc tgtcatgtcc tagaagcatt tactcattag agctatatct 120tctcaaagca gtgagaagcc ttaggcccca cgtattccaa acccaggaac ttgaggcatg 180gtaagtccag ggacttggtc acagttgcac acgagcggtc tgaccaggtt ggcacaggat 240ggcgtacggc ctcctcttgg agatgagcat cttggaggct gcaggcactt ttctggggcy 300gacaatttag gctaagaggg cctagggcag gggcctgcgg aggggaagcg ggctgtctag 360gactggctct gaggaggaaa agagagtgag agggatgctc aggattcctt ataagccatt 420aaaaacaaat aggcattcaa gttcagtgca gggtgaaaga gcacaattga tggagcacat 480ccgcccactg tggcctctgc tgagatacag agagttagaa cctccggcat ctgctaggag 540cccccggcct gtgttgaggc aaatgactcg ccagttgggt ttgctggggc tctcagcga 599134599DNAHomo sapiens 134caggttggca caggatggcg tacggcctcc tcttggagat gagcatcttg gaggctgcag 60gcacttttct ggggccgaca atttaggcta agagggccta gggcaggggc ctgcggaggg 120gaagcgggct gtctaggact ggctctgagg aggaaaagag agtgagaggg atgctcagga 180ttccttataa gccattaaaa acaaataggc attcaagttc agtgcagggt gaaagagcac 240aattgatgga gcacatccgc ccactgtggc ctctgctgag atacagagag ttagaaccty 300cggcatctgc taggagcccc cggcctgtgt tgaggcaaat gactcgccag ttgggtttgc 360tggggctctc agcgaggagc agaaaggaga cagttgtcca aagagaggac attagcaaaa 420tcagtgcccc aaaccaagtt gaatcatagc tgtaaatact cagaggaatt aacctgtcac 480cttggtctga agttcagctg tgagggaggg gacccagggt tagcagaagc catctgagca 540gaagctgctc tgagcagtgt gaccttaagc aatgcaagga tcttcaaaga gtgaccaag 599135599DNAHomo sapiens 135tgtaaagtta aagcagccaa gtgctctctt tttctctctt tgcttaatat gaacttgaat 60tccctcttgg ccatactttt tctaagtttc acaatttgaa tgtaataata tgataacact 120gaaaatcaag agaaacaact tgaaaagtca gtaactggtt tgcaactcac tgcagaaaac 180aaatgtaact ttaacatcac aacttccttt tgatttttaa aaaaatcaac ttggttatca 240ccattactca tcagccttag ctcaagtgac tttggtaatt tcaaaaacac atgactaaar 300aatgaaaatg taagggtatt ggctattttg tgccttggtt tgtgagtttc taaagatgaa 360ttttaaaagt ggtttgattc aagaaaatca ttatagaaag tgtgtgatct gcttacatgc 420ttacttccaa gaggacagct ctcatataaa tgcttaattt catgtatatt tgttaaaaaa 480tgcaagccag ttatggatca tatcttagta acaccttcat tcatctttta atttcattct 540gtacacagtg cacatgatca ctgagtagaa ataaacaatg taacagaatc ttgaaagtt 599136599DNAHomo sapiens 136atgtttcata ataaacattt taaaatgtaa agttaaagca gccaagtgct ctctttttct 60ctctttgctt aatatgaact tgaattccct cttggccata ctttttctaa gtttcacaat 120ttgaatgtaa taatatgata acactgaaaa tcaagagaaa caacttgaaa agtcagtaac 180tggtttgcaa ctcactgcag aaaacaaatg taactttaac atcacaactt ccttttgatt 240tttaaaaaaa tcaacttggt tatcaccatt actcatcagc cttagctcaa gtgactttgs 300taatttcaaa aacacatgac taaagaatga aaatgtaagg gtattggcta ttttgtgcct 360tggtttgtga gtttctaaag atgaatttta aaagtggttt gattcaagaa aatcattata 420gaaagtgtgt gatctgctta catgcttact tccaagagga cagctctcat ataaatgctt 480aatttcatgt atatttgtta aaaaatgcaa gccagttatg gatcatatct tagtaacacc 540ttcattcatc ttttaatttc attctgtaca cagtgcacat gatcactgag tagaaataa 599137599DNAHomo sapiens 137tttgatcatt tcctaatttt gttgttgtga ttttctgata tgggaaggtg ttccaggctt 60gttcttttct tagtcccgga caaagccatt tctctaagga gccatggttc ctttcagtga 120gaaattgttt tcggagacca caatttgggt ctaacagttg cacactctta actgagttca 180tcaatgtttc taggctttct gagtagatat aataaggaaa tacatataca tccataaaat 240gaattataaa ttaatactga aaatccaatt taaatttagg accgcaggtt ttacttagcy 300tcatcaactt tacattggaa tcactgccac gcagaaaatt ccagttccca gtggcatcaa 360cataattgtt aatttgcttt atccctcaat gtacatatat ccaaaaggca tatattgcag 420aagaattata ataccaacac atcctttaat attttgtttc ctaaaaatag ttgaaaacat 480ttttgtacta ttttatccct tgagaatatt tcactagaat atagagtcat cattgtattc 540taaagttatt tgaaattatt cctcttattg tggttttgtc agttaaacat atttatttg 599138599DNAHomo sapiens 138tttctgatat gggaaggtgt tccaggcttg ttcttttctt agtcccggac aaagccattt 60ctctaaggag ccatggttcc tttcagtgag aaattgtttt cggagaccac aatttgggtc 120taacagttgc acactcttaa ctgagttcat caatgtttct aggctttctg agtagatata 180ataaggaaat acatatacat ccataaaatg aattataaat taatactgaa aatccaattt 240aaatttagga ccgcaggttt tacttagcct catcaacttt acattggaat cactgccacr 300cagaaaattc cagttcccag tggcatcaac ataattgtta atttgcttta tccctcaatg 360tacatatatc caaaaggcat atattgcaga agaattataa taccaacaca tcctttaata 420ttttgtttcc taaaaatagt tgaaaacatt tttgtactat tttatccctt gagaatattt 480cactagaata tagagtcatc attgtattct aaagttattt gaaattattc ctcttattgt 540ggttttgtca gttaaacata tttatttgtt ttgttctgat ttttaggaat tgattttta 599139599DNAHomo sapiens 139attatagatt taaaaatagc tagaacagag ggttttaaat gtcctgatca caaagacaat 60aaatgtatga agtgatggat atgctaaata ccctgatttc agttttaata atgtacacat 120gtatcaaaac atacagtgta ccccacaaat atgtacaatc attatgtgtc aatttaaaac 180acattgacca atggaacaga atagatggtc cagaactagg tctaatagga tatggaaatt 240gaatagacat taaatgggca tcttatgtta gtgggtaaaa aaatgaactt tttaagaagw 300ggtgttgtga taaatacaca gacatatgaa aacaatgcaa tggatccatt tctcagacta 360aacaccatag taaattccaa atggattgaa gatttaaagt gaaaaatgag tccatatctg 420tattgaaaga atggattaat tcttttaaaa tctaaaagca aagaaaaaaa actggaaaac 480aattgcaatt tacatcacaa agtcttaata tgtctaccat gtaaaaacct tcccacaatg 540ataatgaaag agatcaaaat ctctgtagag aaatgggcca aagctaaggc acaagcact 599140599DNAHomo sapiens 140cataatggct gtactaattt acattcctac caacagtata taagagtttc cctttctccc 60tgtttgtacc agcatttgtt atttttttat ctttttgata attgccattt taattgaggt 120gagtttttat ctctttgtag ttttgacctg cattttccta ataattagtg atattgaaca 180tttttttcat atacctgttg accatttgta tgttatcttt tgagacatag ctatccagat 240attttctcca ctttaacagt attaattcta atccatgaac atggaatacc tttgcaataw 300tttgtgtggt cttcaatttt ttaaatcaat gttttatagt tttaagtgtg gagatttttt 360gcctccttgg ttaaatcatt actaagtatt ttatttcttt cgtagctatt gtaaatggga 420tcgttttctt gattccttta tcagacagtt tgctattggg gtataaaaat gttatggatt 480tttgtatgtt gatttcatat cctgcaactc tactgaattt attagttctc accatttttt 540agtgaattct ttggcgtttt ctatacatat tatcatgctg tctaataaac agggataat 599141599DNAHomo sapiens 141aaatagagaa aaaatagaag aatttgcaaa ttagtctaat aacatttttg gaaataagaa 60agcatctcaa aatagaatga tatgaagctc cagattgaaa gagcccacca attaattact 120cagcaaaatg gagacagaac tgccttaaca ttttggaaga aaatattatg tattgcctaa 180atttctctac tgagtcaaac aattattcaa atatgagggt aaaatagata ttttcagaca 240agtaaggcct caagatattt cctgccatgt ccctttgtct gagatctcct ggaagaagcr 300gtcctccata aagggaacat atagtacttt gggcttcagg gaaatggaat ccagctaagg 360aaaatggtgg aaggcatctc cagatctcca gactgatgat aaatggaaat ccaatgctgg 420aaattgtgca tttgccatat ttaagcagaa gagcaagttc taggtagatg gtctttagga 480aggagatttc ctaatgtgtt gaatgcattg aaaatgcatt aatgtgagaa tgcattaatt 540ttccactaga aatacatttc tagtggagaa tttaaaaaaa tattaatgaa agatataaa 599142599DNAHomo sapiens 142aaatgtcttc atatgtaaat atatggtcta aattatgtgg gtcagatact aggtttgcta 60aatgttttaa ggttataaac tactttttta gcttttgaga accatttgat ttgtatactt 120tacaatttgg gaaggcttgt ggacatatgg aattgcccac ccctttaact atgctggaaa 180gagtaagacc ttatctgtga atagaacata attaaaataa cttaccagag gccagtctga 240gggctccagt gcccaagtag aggcagcagg tggctcccaa ggcctgggcc agccggccty 300cttcagtctg aaggccacgc ccttcttcct gctgctgtcc agttgtcttt tgactgccac 360atatggaccc ccaaagatct ccaaaggaaa ctttcctcat tacaggagga ggtggctatt 420ttggtttcca cctgggccat gctctgaacc aaaagggagt ccacgtaatt ctatttgaca 480tcagcagtcc tgctcaaacc attccagaag gaatcaagtt tgtacatgga gacatccgcc 540acctctctga catagagaaa gccttgacac agatgtcaca tgtgtgttcc atattgcct 599143599DNAHomo sapiens 143tatgtaaata tatggtctaa attatgtggg tcagatacta ggtttgctaa atgttttaag 60gttataaact acttttttag cttttgagaa ccatttgatt tgtatacttt acaatttggg 120aaggcttgtg gacatatgga attgcccacc cctttaacta tgctggaaag agtaagacct 180tatctgtgaa tagaacataa ttaaaataac ttaccagagg ccagtctgag ggctccagtg 240cccaagtaga ggcagcaggt ggctcccaag gcctgggcca gccggccttc ttcagtctgm 300aggccacgcc cttcttcctg ctgctgtcca gttgtctttt gactgccaca tatggacccc 360caaagatctc caaaggaaac tttcctcatt acaggaggag gtggctattt tggtttccac 420ctgggccatg ctctgaacca aaagggagtc cacgtaattc tatttgacat cagcagtcct 480gctcaaacca ttccagaagg aatcaagttt gtacatggag acatccgcca cctctctgac 540atagagaaag ccttgacaca gatgtcacat gtgtgttcca tattgcctct tatggtttg 599144599DNAHomo sapiens 144acaggaggag gtggctattt tggtttccac ctgggccatg ctctgaacca aaagggagtc 60cacgtaattc tatttgacat cagcagtcct gctcaaacca ttccagaagg aatcaagttt 120gtacatggag acatccgcca cctctctgac atagagaaag ccttgacaca gatgtcacat 180gtgtgttcca tattgcctct tatggtttgt cagggaagga gcaactaaat caaaacctga 240tcaaagaggt cagcattggg agtacagaca acatcctcca ggtttgccag aggagggggk 300tgccagagaa gaaggtgctg gaggcgaaga gcacacccct ggacagaggt gatggtgtct 360taagaacctg ttctctgagg ccggctggca tctatgggcc tggagaacaa agacaccttc 420ccagaatagt cagctatatt gagaaagaca cgttcaagtt tgtctgtgga gatcctagaa 480gcctggttga gtctgtccat gtggataact tggtgcaggc tcacattctg gcctcagagg 540ccctgagagc tgacaaggga catattgcct ctggacagcc ctactttgtc tcagatggc 599145599DNAHomo sapiens 145tggcttaaaa cgttgctgat ccttgttttc cagaggcaag gaaacttatt ttgagttatc 60tacagtcttt aataattgag taagctatac tcttctgaac aaaatttgga gcgtatttgt 120ttctctctct gcctggcttc tcctgaattt ggaaactatt tgtaagtatt cttaccttgc 180ggcaatacag ttatttgcat cagtgtaata aaagtccatt ttcttttgca acaggacaca 240attggagaaa ctggttgttt accaaggctt tgactggaag gatatgcttc cacttaaggw 300atctggcttg acttgaagag ccaataaaag ccccctagga aaactggcct cattccttgt 360ctacaccatc cctgcacagg attcctaacc tgtgatgact aaagaatgtc attttctaac 420gggccctatg tttttgggac ttaaagaaga gagaaattca caaaactcat aggtgtttga 480gggtacaaac ccacggctag gctgggcttt aaaaggtctt atctgagatt tcttgtggaa 540cagaattccc tcaaagccaa tttaaaagcc tatgtgaaaa ataattattc ttgctgcac

599146599DNAHomo sapiens 146aagaagtaca gcaatgagag atacgtggtg aaacctattt cactggggat tcaatccaaa 60ttttaggaaa ataataaaaa ctcaaaaaca attaatggtc agggctgcga tctaataaca 120ggtatgctat aatcttcctt ggaaacataa ttttactctc tccagtttcc catttctacc 180aaagataaat cttactagga tcaatttact tgtaaaataa gatatagtat tatacttggt 240ctgattattt gcataaagtg caataagaat catgattaga cctataggct gttttaagtw 300ggctttgctg gaactttcac agggcatttt ggattacact tttaaaagcc tcgaggttag 360gaagccaagc caagaatttg ccaccaggat gtacctgtga tacctgtaca aattgggtaa 420attcctctct tcttgaggtt ccaacatgtc ttgaggaccc tagagctgtc agaaaatggt 480attctttact tactgcaaaa ttagaaacct taaaaaggaa ccatgtacat aagttactat 540gccatccttt tcaagaggct tttgattggt tctataaagt caatttcaat tcttcaaag 599147599DNAHomo sapiens 147gaagtactgc tctcttacct ttatttcctg ctcttaagac ataaaaaaaa gaggaaggaa 60cttcaagtcc ttatttcagt aactgccagc ttttgtatct gaacgaaaat atgtgaaaat 120atccattttc aaagggttct actatatttc ttcctatcca gagagatacc tggagaagac 180acaatagcca cgttacacca gctcaaaaat aaaggattat aactggagga aaaaggaaaa 240ccttattttg taaatgacca tggacattgt gaaatggatg gtcatacaga ggaaaatcar 300ataaactacc tctttcagta ggaagtgctc tgaagaagaa gcatctcaaa ctcttctctg 360accaacctcc ttgatgagat aaagtttgtg gttgggttta gttgaaagag tgagtaagct 420ggtttccttt acaggaattt cctgtaaaga atattaactt tcaactcaat ttctcaactg 480tgggttttgg ttttcttctt gtaaaactaa tctctaaaag tgtgaccttt gagataaaca 540ctaaagccta ttttgtgatt aactttctaa ttttgaaaaa gaaaaattat gtctccaac 599148599DNAHomo sapiens 148aaaaaatgag ttgctaatac aattactttt caagaaatat tttagaataa caaaatgggt 60tatttactaa caaaatttac atctccatat atacggagtc ttcacttaaa aaaactgatg 120gttataaaat aaacccgttt aaagtgcttt gagcatttta caggaagggc taagagcaga 180gagattcaag atatttgcca aatttgaatg cccatttaaa cttaactgta acatctttga 240tggcaggtac tacagcttca ttttctgtta tccctagaca atggggtcta aagccaccay 300ggagcatctg agaatcataa tgatattagt taaattaaat actgtcacta ttacacgaga 360ccaaatctct gtctgcaggt gttctctgtg taaagtagtt taagtctgcc tttgatggtg 420acatttctct ccctgggtct cagatccctg ttgacactgc tttctccagc actttcctct 480ctctcccccg tttctcacca aaaagttttg tgggtaaagt ttagttcatt atttctgcca 540gagacagctg aaggtgtagc cttgaccaac tgaaagggaa atcttcatcc tctgaaaaa 599149599DNAHomo sapiens 149aaaactgatg gttataaaat aaacccgttt aaagtgcttt gagcatttta caggaagggc 60taagagcaga gagattcaag atatttgcca aatttgaatg cccatttaaa cttaactgta 120acatctttga tggcaggtac tacagcttca ttttctgtta tccctagaca atggggtcta 180aagccaccat ggagcatctg agaatcataa tgatattagt taaattaaat actgtcacta 240ttacacgaga ccaaatctct gtctgcaggt gttctctgtg taaagtagtt taagtctgcy 300tttgatggtg acatttctct ccctgggtct cagatccctg ttgacactgc tttctccagc 360actttcctct ctctcccccg tttctcacca aaaagttttg tgggtaaagt ttagttcatt 420atttctgcca gagacagctg aaggtgtagc cttgaccaac tgaaagggaa atcttcatcc 480tctgaaaaaa catatgtgat tctcaaaaaa cgcatctgga aaattgataa agaagcgatt 540ctgtagattc tcccagcgct gttgggctct caattccttc tgtgaaggac aacatatgg 599150599DNAHomo sapiens 150tagccttgac caactgaaag ggaaatcttc atcctctgaa aaaacatatg tgattctcaa 60aaaacgcatc tggaaaattg ataaagaagc gattctgtag attctcccag cgctgttggg 120ctctcaattc cttctgtgaa ggacaacata tggtgatggg gaaatcagaa gctttgagac 180cctctacacc tggatatgaa tcccccttct aatacttacc aggtatgtga ttatcattga 240gaatgggcac tgccattcca agcaatgtga gccttggttg tccatctgta atatgagaar 300gacagcaccc cgcttcactt tacagaaagt aaatgagtgc cacattattt tattcccata 360agcagagtct gaagcttgct ttggcttaag ttgcccagtg ctcaataaat gatgtactct 420gcattttggt ggctccttcc gattcggtga agcattttag tgacggcagc atggaagaca 480tcacttagac attagatggc cttcaaaagg tagatattaa caagcaagcc acacagtgtg 540ggtgtgttgt cccacataaa tgagacttcc agaatggtct tgggctcatg ttggtcagt 599151599DNAHomo sapiens 151ctgcctactg atgcacccac ccaccaactg gcctcagacc tccagctgcc tggggctgat 60tgcaggctgc agctatcact ctgggacagt gtttctcaaa tcatcttgat tataagaatc 120acccgaaacc cttattacaa atgcagattt ttgggcttcc tgaggactta ttaaatcaga 180ttctcaagga gaagaacaat ggaacctaca ttataaacaa gtgtcagagc caccacgctc 240atctgggaga cacttttggg aaaccctgct cagggataag catagagctt ggggaggtgr 300gttagtgctg agttacagta gctgttgcca gcattgtagg caactgacca acatgagccc 360aagaccattc tggaagtctc atttatgtgg gacaacacac ccacactgtg tggcttgctt 420gttaatatct accttttgaa ggccatctaa tgtctaagtg atgtcttcca tgctgccgtc 480actaaaatgc ttcaccgaat cggaaggagc caccaaaatg cagagtacat catttattga 540gcactgggca acttaagcca aagcaagctt cagactctgc ttatgggaat aaaataatg 599152599DNAHomo sapiens 152tactgtgtgg ctccaattaa gtcacttagg ctctttttgg acctcagctt tcttacctgc 60aaaataaaat gtctggactg tatcagtagt tcctccacct tagaatgagg gaatcagaat 120ttctgatgtt taagtcggga tatttgtaat ttttaaaaaa gctccctgac ttgtaaatca 180taagatcaga tggttgctaa gatcctccca gctctaccat cccgcaattt atgtctaaat 240gtccaagcct atagcaaatt agttaccacg atgcccagca gtctccagca ctcaggaatk 300tccgccaacc ttgagatgac agatactgcc tactgatgca cccacccacc aactggcctc 360agacctccag ctgcctgggg ctgattgcag gctgcagcta tcactctggg acagtgtttc 420tcaaatcatc ttgattataa gaatcacccg aaacccttat tacaaatgca gatttttggg 480cttcctgagg acttattaaa tcagattctc aaggagaaga acaatggaac ctacattata 540aacaagtgtc agagccacca cgctcatctg ggagacactt ttgggaaacc ctgctcagg 599153599DNAHomo sapiens 153gaatgccacg gataggtgtt aaggtcactg cattatcccc attgctgaca actgacagct 60cttcttacaa ggactgcaac caaggaacaa ggcaggatca gcaatggcct ttaaagatgt 120ggtctcccca cttgcctttc ccttgtccac aaagtctccg aaagaacagt cctccaactc 180caccaccaga cacatcttcc taagcagcaa gcctgggcat ttcatttcca tgcccaaaac 240gtcaccggct cccaccaccc atgtgatgaa gcacagattc cagagcacca tggacaaaay 300gctgtagcgt ttggctctct catgtcttcc ctgatttctt cctcagagag tcgttccctg 360accacctgga taaagaagcg ccctctccct tcttgccatc aaccatctct cttgctactc 420attttaaatg acttttgtct tagcacatat tattgtctga aaatatctta ctcctaaaac 480ttctccccaa ctagaatata agttccatcc cagcaggaac tgagtttgtc tttctgagtc 540ctgcagcctc tctgcaggaa tagtgcctag ctgataacag gagctcagta atgacttgt 599154599DNAHomo sapiens 154ctcctctctc tccaccctga agctctccgt tatctcaccc cagctgcaca tgctgagctt 60ttggtggcca aaccaagact ctttggtgga cacttttcag tccttctcat gcccaactcc 120tctgcagctt ctgaaactga tgtctagtct ctcctccaag ctttctctgt ctggattgcc 180aaggtggtct ctctgctctg ctccttgcat tccttttagg tttgtcattc tttattttcc 240attagccctg gcctactttt aaaggttgag gttcctcagg gaagttcatc tgccctcccy 300tatggggcaa cagaaacaat ccaggcttgt tacagatgcc ccaggctccc tccagctgct 360gaaactgaga ccctgctctg agccatatgc ctccccaccc ctctgccctg ggaatgctcc 420agctggatcc ccaagatatt tcaagtaagt ggtttgaaag gtcccatgac tgccttatca 480agagagggga ctcaagtcct ttggacacag cccagatctg attctctgga ggggacctgc 540tccccctttc atatttgaga gttgatagtg gtgccatcca gtgacaattt tccctcttg 599155599DNAHomo sapiens 155aggtggtctc tctgctctgc tccttgcatt ccttttaggt ttgtcattct ttattttcca 60ttagccctgg cctactttta aaggttgagg ttcctcaggg aagttcatct gccctccctt 120atggggcaac agaaacaatc caggcttgtt acagatgccc caggctccct ccagctgctg 180aaactgagac cctgctctga gccatatgcc tccccacccc tctgccctgg gaatgctcca 240gctggatccc caagatattt caagtaagtg gtttgaaagg tcccatgact gccttatcar 300gagaggggac tcaagtcctt tggacacagc ccagatctga ttctctggag gggacctgct 360ccccctttca tatttgagag ttgatagtgg tgccatccag tgacaatttt ccctcttgca 420tgtggggcag ggagaggtag gtggcctcta ttctctaata gaatagacta gtatatgcaa 480acattctcaa attttataaa taggagctat atctctagct ttcctaaccg tgaaaaatct 540gacagtttta ttcaacttgg gtcatttttt caggaaaagt taaacataac tcttttcaa 599156599DNAHomo sapiens 156gccctgagta tccccttcat ttctgtaaat caagaaatgg gaaatgaaga agtcagaacc 60agtgaacaaa gtgcatctca cacaggaagc tttgaaaggg caggtcctac ccaaaccggc 120cttcacttgc ctataactta cgtgagtatt tccaatggtg tgtagcaacc ttttcacttg 180tgtcatttct tacaaatcat ctcaagctcc caatatccct aggctctatg cagtgtgttc 240ttttaatgcc atttttcccc tcattaatct tttttctttg atgtgctcac ctagcatgtr 300tatttccatg agtaatttga aaagagttat gtttaacttt tcctgaaaaa atgacccaag 360ttgaataaaa ctgtcagatt tttcacggtt aggaaagcta gagatatagc tcctatttat 420aaaatttgag aatgtttgca tatactagtc tattctatta gagaatagag gccacctacc 480tctccctgcc ccacatgcaa gagggaaaat tgtcactgga tggcaccact atcaactctc 540aaatatgaaa gggggagcag gtcccctcca gagaatcaga tctgggctgt gtccaaagg 599157599DNAHomo sapiens 157tgggctggat atttctttgg cttgttgcag gagagcgaat taaaggattt aatatttcag 60gtaggggttt tcacttttca tgttagcact gtgagtctgt ggtcaagtgt aaagtgatgg 120ataacctgat atatcagcag tgtgatatat taatacaaac ctttccatcc tactattaaa 180aggggactga gaggagaatt attagggtga acagctttca gctgatacca agcattgtcg 240aggtaccctg ttactgtagt tgagtgttca gtgagatcag ctgacgaggg atgagccagm 300gttctaccat cttttccagg aaaccagggc tgctgctggt atgctggagt ccactgggag 360ggaattagaa caggcacttc ctttccccta caaaatagac agtgaagaag aaagacacac 420aaggaagcta gatctcttgt taaatcaagt actagatgta aatataagct agaattccat 480tttctaatgt gtttccatgt gctttgttta ttatgatttt caggttgttc cacaaaaaaa 540ctcctttgga catattctac aaggagtgaa gaggaatttg tcttattttg tgatttacc 599158599DNAHomo sapiens 158tgtgttgagt cctcccttcc cctttgcaat gcctgttgct ttcctaagac agtgaaaatg 60agtgaaccta tcttcctaca ttagcagatg ttagtaggtt tatgtctaac ctcatgtgta 120atatacttga attttagaag tttctctggt gttgatcaaa aggatgcctc taataattag 180aatatcaagc tctgtggctt cccagggaac atgattattt tagaaagtca gatctcctgc 240agaggcacag ggccagtttt tgagaagctg tatacctcag attctcaaac acgcttttcy 300atgaaaagcc catgaagaag ataccataaa aacaatgctc ttatattaat tttagagaat 360tcactcttac cttgtaccag gttaccgctg gactttgtgc atcactttgg cagctgagac 420tggggcaaga aatagagcca gtgctcccaa gaagtaggtc ttgcttatgt gatgcggaat 480actcacagga tgcatttgtc tggggcttaa cttctaaaat catcttgaca caacaggcta 540catcataggg gctcctagga aattaacaag atcctgtgaa catagatatt ttgtctaga 599159599DNAHomo sapiens 159tgttatggga gttcacgtac atgtggttca tagctaaaag tcattgtgaa acttgctctt 60gttccctttt tctatttgca ctgtactcct ttccaccatc tcacctgtgc aagacatctg 120tcactcaggc ccaccttgga ttcgtcctaa ctgtcctcca agagctgtct tttgggaatg 180tatttcaggc tcctgtaact ttcacaaacc cttcaagact tatgtgttga gtcctccctt 240cccctttgca atgcctgttg ctttcctaag acagtgaaaa tgagtgaacc tatcttcctr 300cattagcaga tgttagtagg tttatgtcta acctcatgtg taatatactt gaattttaga 360agtttctctg gtgttgatca aaaggatgcc tctaataatt agaatatcaa gctctgtggc 420ttcccaggga acatgattat tttagaaagt cagatctcct gcagaggcac agggccagtt 480tttgagaagc tgtatacctc agattctcaa acacgctttt ccatgaaaag cccatgaaga 540agataccata aaaacaatgc tcttatatta attttagaga attcactctt accttgtac 599160599DNAHomo sapiens 160gcatcttttt ttaaaatcta ttgaccatta aatgtattgt atatatttaa tctattgtaa 60atgtatacaa ttatgatttg ttaattaaaa ataattttaa aataaagaag ttgaaaaaaa 120tttaaacaat ctgcaagcct gttcttaatt cgccaattaa aaatattgtg gaatgctcca 180gagactccaa gcccagggat ttatttcagt tgtatactct gtatatctgg tgggtgtatc 240cctggtcagc agttttattt gaattcagta aagccatgtt ttcattctct cagccagtgy 300cagcttcacc tattcagaga tgggtcgtag gtatgactta cccaccacct gagaacctgg 360gggttagcat gaaggaaaaa ggcattaggt gttttttcct gcctaatgcc atcactttta 420gtgatgtact actgccataa ggtctgtgat ttccaggtta ctatgtgcct ttatatgcat 480gtgtatgtgt gagtgcacac acacatatgt gtaattcaca aaaccaggac ctgtccaaat 540ctgtatcaga ggtacaattt tcataacagc cattgttcac ctattcttaa ggtggctgc 599161599DNAHomo sapiens 161ctcttttttc ttagtctagc taagagtttg ttaattttgt ttttagtttt ttcagtaaac 60caactcttag ttttattcat tttttcctat tgtttttcta atctctgttt catttatttc 120tgcttttatc tttgttactt cctttcttct gcaaactttg ggcttcattt attacccttt 180ttctaacatc tttctgtgta tcattagatt gcttatttga aatctttcct gtgtttcaat 240gcagacattc attgctataa atttccctca ggactgcttt cgctgcatcc cacatgtttk 300agtacactgt gttttaactt gtttgtctca atttattttt taacttcctt tttatttctt 360ctttatccca ttggttgttt aggagcactt tgtttcattt ctgcatatgt gcatattttc 420caagatattt tctgttttta gatttctacc tttatgcctt tgtagcccaa aatacacttg 480atatgatttc aattttctta aagttgttaa gacttatctt gtagctgaac gtatccttcc 540tggaaaatgt tctatgtgta cttgagaagg atgtgtattc tgctgctgtt ggatagaat 599162599DNAHomo sapiens 162gcagactgtc ttcccaaata gcctgcaact ttgcctgatc agaggcagtc acagagcaat 60acccttgtgt cttccattca cccacaacat gaaggaattg cttaattaac taaaagggca 120cccaaatgcc ctacatctgg ccgagaaata ctgttgttag aatgtgtagt tgggcaggac 180aacaggctag gccctgaggc aaagttagtt atctgggatt gctgctcagc aatttgggat 240gggcaggggg agaaactagg ctacaaagat gtgtgtgggc ttgatcttac ccctgggccr 300gggatagcct taggcagggc attgaggctt gattgggttg ccacgcacct tctggacctg 360ggtggggcca gctgctcctt ctgcagataa ctgctgacct gcctttgcct cctggcctgg 420ggaaggctgc aggaaggtgc tggagcctgg ctgggtcacc atgcttggag attattaatt 480aaaatattta atgactgaaa aagtcagaat taaagtgagt tatttattat ttatgctact 540aactttttct atatattttt ctaatttcta aaaatgtaat gaaaaaatag ccttggcat 599163599DNAHomo sapiens 163tatatttatt tctgttaaat aatttgttgt ttttagttca ttctacatgt caagaggttg 60gaattctgat tttgaatgcc aacatattag ccatcacacg caggtttgtg aggcatgtag 120atgagatcaa catggtatgt tctccctcaa gcccctgcta aaactacggg cgaggctaac 180accagggaca gagtgctctg ctgttaactc cagtttgatc cttctagtta catatgatcc 240attcatccac aacgcaaggg tgttgcttaa ttaactaaaa gggcactcga atgccctatr 300tctgatcatt cagctcacaa tgtacctttg gtttaacaga gagatcatga gaatattttt 360caagtgactc acaatagtga agatactctg tgtctgccat actcctgtga acctccagtc 420tattcagttg tgggcaacaa tgagattgcc ttgatatgat tgttgttagc aaatgcaagc 480tggctgatat taaccatcac ttccttttct aagggttcat aaaccatctg ttaaataatt 540aattcaagac tttcactaga aattgacatc tagcccatta tcaataattt ccataatat 599164599DNAHomo sapiens 164ccagtctatt cagttgtggg caacaatgag attgccttga tatgattgtt gttagcaaat 60gcaagctggc tgatattaac catcacttcc ttttctaagg gttcataaac catctgttaa 120ataattaatt caagactttc actagaaatt gacatctagc ccattatcaa taatttccat 180aatatactcc attcccatta aaagataaat attagtaaaa aaaaaatcta tcaatagaat 240gttgttagtt gataactggg gcaagagact gcaactacac ttaacgggaa agagcaacay 300agacaacaga aacagaaaag caaagggtat gttcagtgta tggtcacact gagtggctca 360ctgtggtggg agctgagagt tcttaagtgg tttaattagg actagaatgg aaataaaggt 420tgtgtggttc tcatgatggt tatggggacc ttgctgatgt gtttgaactt tatgagtgtg 480agtcctgatc caggacagga cagaaagaag tggaaacaga aagaaggtgg cagatgctag 540tgatattttc atgtaataaa atgaaagatt aaaagctttg actgggagtg tgtgtaaaa 599165599DNAHomo sapiens 165gagcactgag aatcaacctc atttttttct ggttctgagt tttattttct gattgaggaa 60tttcccttcc actttgcctg cctactagta gaagctggga ttcccccacg ccacatccct 120cgtgtgtttc ctgtggtcca agaaggaatt tccagcaggc tggaaaggag actaagggtg 180ggggcagagt ggccagagaa gtgcagctgt gggcaggaag caaaacaagg caaagaggta 240gtggtataca aggctaaata tataccagat gatctcaaga atcaggaact tttcaaaagk 300aagttttaaa acataggggg aaattcaaag ataaaacttc agaggacgca gtgataacat 360ataaagatca gaattcaggg gagaggcgtg tcataaatcg catgagaacg taatggtggg 420aggacacaga gccgtaacta agacctcacc taagccaagg gggaggatgg ggaataatgt 480atctttttta cccataaata ggtaagtgag gcttagtatg tatcattaag actttatgaa 540atggaactta gaggaaatat caaagaaaag aaattaggga gaagcaattt atgccaagg 599166599DNAHomo sapiens 166ctgtgagttc gtggacagtc agagctgttg ttcaagtgag aaccattggt aagtgagatt 60tttatctcaa gatttgagat ctgagcagca aattaaaatt atcttctttt ggcttagtaa 120gtttttcctc ttagggaaag aaaaggatag tcatatactt gtaatcatgt aaaacctttc 180atgtgggcaa acatcaaagt tgccatcccc cagggaaggc taagttctga aacagtttca 240aattctcaca agttgggttg tccatgaata tgtccctgat ttgcttttgt aataaatttw 300aaaaatgtat gaaacatttc acacacagaa atattgtgac atccaggtac ctatcaccag 360ttttaactat gttaccattt tcccacatgc ttcaaatcat aatttttttt ctttaaagta 420acaaaatatt gcaaagacaa cttgaggtct atgaccccat tctcttccag gcctttgctc 480ccacagtata gtaacatctt gtcatttata tcatttccat ttatgttttt atgctttttc 540tacatatgta tgcatctatt aacaaaatag aatattgttt tgagttatga aatatgttt 599167599DNAHomo sapiens 167gagtttcact tggtcttggg gtgctctgtg tggtttgtat cttgtaataa gaaaagatta 60atatcttaac taacagctac gtcaaccact ctgttgctct ttgatataaa gcatgagtga 120ctggctgtct tatgttttca cttcttagac cacatttaaa ttaattctat cacatagttg 180attcaagctg atgcttgcag atctggtaag aacgacccaa gggaaaggtt aggacaaaaa 240cagacaagtt gcggaagaaa gccaatgaac caaaaaacat atagcaaaat gttcaaccty 300atattagtca gggaagtata ctatggagca gaaaagaaac aaataaaaac aaagctccac 360ttaacaccag tcataaagtc tgataacacc aagtattatt tgggaacaaa gggcatttac 420tgctaatggg gctgtaaatt ggcaaaccaa taatttaata aaataccaag tgtttatgac 480acaaacatat ttcataactc aaaacaatat tctattttgt taatagatgc atacatatgt 540agaaaaagca taaaaacata aatggaaatg atataaatga caagatgtta ctatactgt 599168599DNAHomo sapiens 168tttcagtcaa gccctctctg ttgtcatccc tgtcttcctc atttaatcat tcattctcat 60atttattcat ttccacacaa atatttactg aacatgtaat atgtgtcagg cttggagcta 120aggctacaag aatgagtgcc cggatgcttt atctggcctc caagaacttt ccattttgag 180aagaagacaa aggtgaagca ggctgtcata atacagtgca gcaagagaaa ggagcactat 240gggcacatgg aggcccacca gacccaacct ggggaagccc gctccaagtg agagctgatr 300gatgaggaca caccagctca gtaagggtgg ggagcttcca ttccagactg aggaagcagc 360agagctgatg tccaggagat gaagaagagc atctgggagt aggactgaca tcacactctt 420ctaatacgtg ttaaaattat ctaattacct aattatctaa tacgtgttaa aatttatgaa 480ggaacaatgg ggaggcattg aggattttaa gtgggagaat gtcgtgactg aatttgtatt 540caagatagat caccttgttt gctgggtcgg aagtgggttt gtaagagcag gaatggagg 599169599DNAHomo sapiens 169tgaagggaaa gagcatttga agaggagatt aagtattagg cttaaaagga cttttagtca 60tccaagtcat gacgacaagt aggtatttgg acaagccagt ctggagaagt tagggctgga 120gatgtgaatg tgaagatgat cgatttttac ataatatctg aagccaaaga gctgaatgag 180atcacctagg aagtgggcat agagacagaa ggggctagag ccaaacccgg aaatgcttga 240agaggtggag aagaggaaga caatcctcaa agaggatggg aacatacatc agcaagtgar 300tatcagtgga agggtggtga gaagagaaac aaacgaagtg aaattgatga tgtaggaaag 360acataacctc aggcaccaag acctttcata gggaagaggc ctagagagta aacttactac 420ccaggggtat caggaggagt gaaagaacac taggagagga ctaatagtta aaagagacac 480agaggaaggg acaggcacag agaagtgaat atagcggttg aaagtaagca gtagagtacg 540ggaacatgga

accaaaagaa gagagggttt caaagagagc atggccaaca gtgtccaat 599170599DNAHomo sapiens 170gggcataatc acatttttcg tctactttac ctcttagcag cattggacac tgttggccat 60gctctctttg aaaccctctc ttcttttggt tccatgttcc cgtactctac tgcttacttt 120caaccgctat attcacttct ctgtgcctgt cccttcctct gtgtctcttt taactattag 180tcctctccta gtgttctttc actcctcctg atacccctgg gtagtaagtt tactctctag 240gcctcttccc tatgaaaggt cttggtgcct gaggttatgt ctttcctaca tcatcaattk 300cacttcgttt gtttctcttc tcaccaccct tccactgata ttcacttgct gatgtatgtt 360cccatcctct ttgaggattg tcttcctctt ctccacctct tcaagcattt ccgggtttgg 420ctctagcccc ttctgtctct atgcccactt cctaggtgat ctcattcagc tctttggctt 480cagatattat gtaaaaatcg atcatcttca cattcacatc tccagcccta acttctccag 540actggcttgt ccaaatacct acttgtcgtc atgacttgga tgactaaaag tccttttaa 599171599DNAHomo sapiens 171tggtgaattt ggttaagcag ttttagtgga cagatggcgg cggaaatcag gttccatagg 60aggtgaaagg atggagggaa ttagcacata gaactgcctt tcaagaattt ggctgggaag 120gaaggagaat aagtgaggct gggatataag gcagggtgtg ttttctcttt tttaggatga 180tgagactgag catgaataaa tgttgatgag aagaagccca gagaaagcga gagagagaga 240gggagagaga gacaagttaa aaatacagga ctgagatggt gcaaagggga gaaggaggty 300tctgagaagt aaaagtaggt gatgtcaaca gcaaagaccc tggatttttc tttatccaga 360aaaagacaca ccttcaggag gaagtttgac agtggaggca tatttgacag tggaggcata 420tttgtggcaa gaagttgatg gataaaattg ttaattaagg actggactct tctttatttt 480gaaataaacc atgagtttaa ggatggaggg gtggactcgg atatgcttga cttgcacagt 540ttcttgggtg gattctcctt tcagttcaat tactcagcca gatggcacca caaagaaat 599172599DNAHomo sapiens 172tgtgccagaa ataatgaaac gtctacacag ctctcattca gaaatgcata aaaccaggta 60cattttttct aatgggcaat ccttctatct caaccatatg actatatgtt cttaaaatga 120agatgagcat gattatatca ctaagggtcc ttatgtggat tgagggagac actaagaaaa 180ctaagaaaat gaggagtttc tgagatcagc ccggtcttct gcactactgt tgaagtacaa 240ggtgtgtcca taaagaaaat tttactatcc aatatttgtt tattaagtaa aaatcataam 300gttattgtag cacgtggttt aaataaaaaa attatttcga tattaagcaa tttttctgaa 360caattcacta tggatgggca tgcatattat gagactaact tttttctacc catttttttc 420catgaggaat attcacatat gctctgcctc aaatctaata tttaaccatg aaatgactag 480gagctccatt tgaatactca tctttgcacc ttaacgtttt tccactggta ataccttata 540attcactaat acatatgtaa cttgactata tgaattaatc taattttttc ctccttctt 599173599DNAHomo sapiens 173ttcctgggct tgtgccacgc tgctccaccc aggaagttgg gagtcttggc atttattcac 60aatttgagtt ctctgaagtt accaatctac aatccatctt tgtgttaaga aatcttgtgt 120atgtgaatga tgttttaggc tgtgttgctc tgagaccacg atgccagctc ctattcactg 180agtgcttcct acctgtcaca cattgtgata ggcataacac ctctgctgta accacgcctc 240ccagtgagct tgcaaagtgc aggctattat ccatagatta tcaatgggtg atggaggcty 300accggggcta agggtcatgt tgacatcaga tagaaaatgg gtttaaaccc aagggtgggt 360gatgtcaaaa cataccctct tgactacact ctcctactgt gaactctaat gcaatatcag 420cttaagatgg gccccaatga ccttcctgat cttagaaatt cttgctaaat tttattgttg 480tgaccaaaat ctgttctgta cttttttgta atgatgtata cttttcaaaa tgatattgca 540ttttcttatt gatatctgtt aagtatcaga agaaggtact taatgcatag actcttact 599174599DNAHomo sapiens 174ggtgagcctc catcacccat tgataatcta tggataatag cctgcacttt gcaagctcac 60tgggaggcgt ggttacagca gaggtgttat gcctatcaca atgtgtgaca ggtaggaagc 120actcagtgaa taggagctgg catcgtggtc tcagagcaac acagcctaaa acatcattca 180catacacaag atttcttaac acaaagatgg attgtagatt ggtaacttca gagaactcaa 240attgtgaata aatgccaaga ctcccaactt cctgggtgga gcagcgtggc acaagcccar 300gaatcaagct gcccattccc tgcagtgtgg tctggggcta ctcacccacc ttctttgcct 360tgtccttgtc actggccaag gccattatga tcctattata ctctagggtt cctgggaggt 420gaggaatgga ggacattaga gtccatattt tgtgcacaga agagggactg atacatagta 480aaccttcagt aggagttggt cattttaaat atttttctta aggtattgtt attatctatt 540ctcaagggga attcttaaga gtaaggaagg tcagatgagt ctcacaaata aataatgtc 599175599DNAHomo sapiens 175gcatcgtggt ctcagagcaa cacagcctaa aacatcattc acatacacaa gatttcttaa 60cacaaagatg gattgtagat tggtaacttc agagaactca aattgtgaat aaatgccaag 120actcccaact tcctgggtgg agcagcgtgg cacaagccca ggaatcaagc tgcccattcc 180ctgcagtgtg gtctggggct actcacccac cttctttgcc ttgtccttgt cactggccaa 240ggccattatg atcctattat actctagggt tcctgggagg tgaggaatgg aggacattar 300agtccatatt ttgtgcacag aagagggact gatacatagt aaaccttcag taggagttgg 360tcattttaaa tatttttctt aaggtattgt tattatctat tctcaagggg aattcttaag 420agtaaggaag gtcagatgag tctcacaaat aaataatgtc ttagcgtgaa tgcttagaag 480agtcaataat tgaatcaaga atgagccctt tttgaccatc ttacattctc gtggtatctt 540atactattga tctcacagtt ctctaaaagc caaactgttg gctgcttata cgtgttcca 599176599DNAHomo sapiens 176gcccaggagg catgaaactg ctttcacttg agaggggagg agttttccta aagaatagta 60ataatgatga cagcgattac attttctagg tgacagacat tgttttaagc actttcctgg 120tgtcaaccca tttaatacct tgaccaaagc cacacaacta gtaaactgca tattactggt 180ttagagctag ttctcttaag taatagtctg cgtttgggag gccatgttgg aaaagcaact 240cattcatgca ctcattcatt cacgcattca ttctacaata gctatggggt atgcccagar 300tggcaggcat tgtgctaaga cctagcctcc tttccaattt ttctttcctg gctttcaaat 360ccaaaggaca tgatggattc atgttctgat gagtggagaa tggaagagag aaggagtaat 420cttgttcatt gttcaaaatg gtgtgtgtat atcacggata tattaaaaaa aaaaaagctg 480gagtagaaat tctaggtaag gaaaagcgtt taaatttctt tgaaaagatg cccagagatg 540aaattgatat cattcattcc tttaattaat agataactat agttataagc aggtttgaa 599177599DNAHomo sapiens 177atgcccagaa tggcaggcat tgtgctaaga cctagcctcc tttccaattt ttctttcctg 60gctttcaaat ccaaaggaca tgatggattc atgttctgat gagtggagaa tggaagagag 120aaggagtaat cttgttcatt gttcaaaatg gtgtgtgtat atcacggata tattaaaaaa 180aaaaaagctg gagtagaaat tctaggtaag gaaaagcgtt taaatttctt tgaaaagatg 240cccagagatg aaattgatat cattcattcc tttaattaat agataactat agttataagy 300aggtttgaat gtttctgagg cttcaacaag acaaagtgtg ttctggcctg tagtaaacgc 360tctgtgaagg gggttttccc ccatgggagt atgcaggaga tccctcgtgt caggtaagcc 420agatgggact cctggtctca ggaaatttag gctgcagtag gaatgataat acaggaaaat 480aatttacaat atgcaatgag agagatgtaa atggattgtg tggacgttta cgaggggaaa 540aaataaaagg aatatgataa gtttcccagg ccaccctgat caggaactgc ccattcccc 599178599DNAHomo sapiens 178atctgatgta tcccattccg aagcctgtga gttaagtgtt gggattttct acttcttcca 60gtgagttcct tagtctcagt aatcatatgc atttatgaag tatgcatatg aaaatatcct 120ataacaagtt atatacatat agttttccat ctagaataga ggggaatgga catttatctt 180gcacctccta tgagccaggc accaagaagt tcatatacat tatctcatga aacccttaaa 240acagcctgcc caggagttat gattgtcttt attttacata tggggattca catatcagcr 300tatgggccat caactctccg agcaagtact ttttctcctt ggatacgatg tgctgggtgt 360tagcagtact ttgcttactg gatatcatca tgttggatgg ggcagactcc tgcttgatgt 420gtgactaatg agacagaaac actgcaggtg caaagaaggc tcagagaaac tcctgagttc 480atgtgactta atcaaagaat gcctcagcca tttgacctaa aatcagtaaa aatgcaagac 540tgcttcataa attagaattc gatttggggt gaaaaatcaa taccgctcag tggtatgat 599179599DNAHomo sapiens 179aagaaagaaa gaaagaaaga aagagaggga gggagggagg gagggagatt catgtataaa 60tgaacagaat gtgtggatgt tccataagct aaaaactatg aaatacttat gagcaaaatt 120aaagaacaat taaataaaga gagaagcata gcatgtttgg tgatacaaag attcaacata 180ttgtcaaatc aacaatcccc tttacattga ttaagaggtt taacgcaatt ccaactgata 240ttccagcaga attttttgta gattataggc aaactaattc taaaatatat gtgggaaagy 300gaataaacta gaaaaaccaa agctatttgg aaaagaaaat aaagttggag gagtcatgct 360agacgatttt atgaatcaat aaaaagttac agcaaccaaa atggtgtgat attaacaaag 420caatagatca atggaactga gtagaaagtc tagaaataca tccacacaaa tatggcctat 480tgattttgac aaattttcaa aggcaattca ataaagaata gagttttaaa caaatggttt 540tgcatcaatt ggacatacat atgcaataag atgaagctca cagcttatac aaaattaac 599180599DNAHomo sapiens 180aagcatagca tgtttggtga tacaaagatt caacatattg tcaaatcaac aatccccttt 60acattgatta agaggtttaa cgcaattcca actgatattc cagcagaatt ttttgtagat 120tataggcaaa ctaattctaa aatatatgtg ggaaagcgaa taaactagaa aaaccaaagc 180tatttggaaa agaaaataaa gttggaggag tcatgctaga cgattttatg aatcaataaa 240aagttacagc aaccaaaatg gtgtgatatt aacaaagcaa tagatcaatg gaactgagtm 300gaaagtctag aaatacatcc acacaaatat ggcctattga ttttgacaaa ttttcaaagg 360caattcaata aagaatagag ttttaaacaa atggttttgc atcaattgga catacatatg 420caataagatg aagctcacag cttatacaaa attaacttgt aataggccat agatctcaat 480gtaaagccta aatctataaa actgttagaa gaaaacatga cctaggatta gaaaaagagt 540tcttagatgt aacaccaaaa gcatgatccg tagagaaaaa aaaagttgga gtttaacaa 599181599DNAHomo sapiens 181agcagaattt tttgtagatt ataggcaaac taattctaaa atatatgtgg gaaagcgaat 60aaactagaaa aaccaaagct atttggaaaa gaaaataaag ttggaggagt catgctagac 120gattttatga atcaataaaa agttacagca accaaaatgg tgtgatatta acaaagcaat 180agatcaatgg aactgagtag aaagtctaga aatacatcca cacaaatatg gcctattgat 240tttgacaaat tttcaaaggc aattcaataa agaatagagt tttaaacaaa tggttttgcr 300tcaattggac atacatatgc aataagatga agctcacagc ttatacaaaa ttaacttgta 360ataggccata gatctcaatg taaagcctaa atctataaaa ctgttagaag aaaacatgac 420ctaggattag aaaaagagtt cttagatgta acaccaaaag catgatccgt agagaaaaaa 480aaagttggag tttaacaaag ttaaaaccac tttttccgag aaaaccactg ctaaaaggat 540gaaaaaaaaa aacaagcttt aaattgacaa aaattatttc aaaatcacaa gtccaataa 599182599DNAHomo sapiens 182cacacaaata tggcctattg attttgacaa attttcaaag gcaattcaat aaagaataga 60gttttaaaca aatggttttg catcaattgg acatacatat gcaataagat gaagctcaca 120gcttatacaa aattaacttg taataggcca tagatctcaa tgtaaagcct aaatctataa 180aactgttaga agaaaacatg acctaggatt agaaaaagag ttcttagatg taacaccaaa 240agcatgatcc gtagagaaaa aaaaagttgg agtttaacaa agttaaaacc actttttcck 300agaaaaccac tgctaaaagg atgaaaaaaa aaaacaagct ttaaattgac aaaaattatt 360tcaaaatcac aagtccaata aaggacttgt gctgagagtt tataaagatt tctctaaact 420caataataac aagtagctac caattaaaaa aggagcaaaa acttgaatag acattttgct 480aaagaggaca gacagatggc aaacaggcac ataaaaagat gtgcaacagc accatccact 540gggaaaatgg aaattaaagc cacaaggaga aaacacacac acacacacac catggggca 599183599DNAHomo sapiens 183catagattct gtggggatga gaactcagct ctgtacagct ttagcagggg tgaaatgtca 60gtcttccccg ctggcagaaa gcctcgcatc tatgagttgt gaccttggag ctctctaatt 120ggggggctgt agggtctttt acataggtct ctggggatgc gagtgctgga ccagtttggc 180tacccttagc aagtcctgca ggggttttgt ctaacatctc tgtttgaact gagagtgcac 240ttgccactct aagtccttaa atttgttacc tttgccaaaa ttcaaggtca actgaaaaay 300gccccattta acctctgatt gtaccacccc caggtaagtt tctgtgccct ttaaaaagcc 360aactatatac aggaaagtct ctgaccagaa cttggcacag ttaaatatca cttactggct 420tttcttacct ttgtattctg gttcatttca cgtctaggag tttttcataa gccccacatc 480tgtaactgga taattgaaca ggctgaattt actaagatat ctgcagaaaa tggcgttgct 540cttctcccac cattgcctca ctacattttt taaggtcgca tttgcttcaa ctgatcaga 599184599DNAHomo sapiens 184agcttctcta aaacagaagt tgcctctaga aaactgaggg taaaaagaga agaatgttcc 60ctaagctcct cttctggcta tgcacagctg aaaccctggg ggatggatgg gagattctct 120tgccatgtgt accaccctca attagtccca tgagggaaga caggatatag caatctaaat 180tataaggcac ccactgggga gaggatgtct ggccattcct ttcctgccac tgggctctat 240gtgtgagcgg gtttctatga acagatgaca agaaccacag ggattcttgg gactggcacs 300aaaaaggggt caggaaggca ggtcagagaa ggtcaagttt ctacaaccaa tatagttatc 360tgaataatta gatcaaaact gtcaggtatc caatagcttg ctgcggacct aaaattccag 420gatgattctt ttaactctct gctttgcaaa tgaaaactgt ttatattttc ccttcaccat 480cacaagtata aacaggaaag cgcacagcac cctgcgatac tctggtgcac ctgtgaatgg 540atcttttctg agaaattaag ttaactgata attattattt ggatcatatt tccatttat 599185599DNAHomo sapiens 185actcatttat tatatctaat agttttttag tcaattattc aggatattct gtttaaatat 60tttagagtaa tctatttaaa agatcatgca agtggaaata gtttgacttt ttttccttcc 120aatctgaatg ccttttgttt cttttcattg tctaaatgcc ctgactaaaa gcagctctag 180tagaatattg aatggaagtg gcaagagtgt atctctttgt cttgttcctg ttctttcagg 240gaaatgtatt tagtcttttc cctttaagta tgatgttggc tgtgtattat catgttgaas 300aagtttcctt ccattcctga cctgtagagt gtttttaaaa taaaaggttg ttgattttgt 360caaatgcttt tctcagtctg ttgaaatggt catgtggttt tgccttaatt ctattgacat 420gtatgttata tgaaataatt tttaaatatt aaaccaacct tgccttcctg agataaatcc 480cactttgtat aaataagttt gaattgttac atcttcttga tagattgaca cttttctttt 540tcttaaatgt ccctctttat ctctagtaac atttgttatt ttaaagcata tttcgtcag 599186599DNAHomo sapiens 186ctgtagacag tatgtagtcc ataatttttt tctgcctaaa aactggatat tttagatgat 60ttcttgtagc aattcttgat gctgctttct ccccctcccc caactccagg gcttgttgtt 120gcttaattgt ttgctgtttg tttagtgact tggctggact atatcagcaa agtctatttc 180cctgtgcagc tttttatact gatcctcagc cagtgaagcc tggggcatgg ttataatacc 240cctaagccct ttctcccttc ccccagaata acaatggttt tagcaggctt ctctgactty 300ctttcactga tatattaagc ttctagctgg tctgttgtat ctattgacat cacactcaac 360tgttagcctc cagtaactgc tggctgaaat ggcctattgt tttcaacaat gccttgggtt 420ataaattact ccacagtccg atccaattaa agtcaggctc ctttgcaggg taatctttga 480gaccagtctc tgagacatgt tatagcctca ggagagctct tttcagccat ctctttttct 540ggttcttctg ttaaacttct agttggtcta ctctttaact tattgcaatc atggagcta 599187599DNAHomo sapiens 187catattgagt cgattatttt ttctcaaaga atatatgaat atcctttaat agaaagctgc 60tttataatag gtgttttatt tttatttgca ttttattgta cttttctttc taaaaagaaa 120tgagggagca agtctcacat agtgccttgt ggaaagacca aaatgaagaa tcaaaagact 180tatgtactca gacattagtt atctgattgg ctttggaaaa ttacctgttt gagccttata 240gtttgagcct ttatagtttt ctcatctata aaataaagat gctgtccata cctggtaacm 300ctttcctgct ctaaaattcc aaattttgtg agtatatggc aacccgttta gccttatgat 360cacctgatgg ctgatagtcc agtccctctc agagtaaaaa tgccaatctt gggaggatgg 420taagagaaca acttgagctc tgcaacagtc tactaacttg tggtccaggt taagatgtag 480cagcccactt catcaaccat cggcatcact tccactcatg cagtactttc ttacagatgt 540cagaacattc tttctaaaat gatttcttag tataaggtcc ccagaaagtg tatgtgaga 599188599DNAHomo sapiens 188tcttgcagtt tgatgtaaaa gagatgttgg ggtagtatat ggatgatgta ttattctcat 60tttttactga gtatcagtaa tcattgcaaa agtgttgtat cttatcctaa aagtataaga 120aatgtaattt aaaataaaaa ctaacattta agtgccaact acatgccaaa ttctttactt 180gctttatctc atttaatgtt cctagctact caatgaggca gatattttcc tctctgtttc 240agataaggaa tttctgaaag gtaattaact tcaccaaggt cacctggcaa caagtagaas 300agcgagaagt aggctcataa aaattatctc aaaattcttt catcaacatt ctatgatgct 360gcttcttttt aacaacaaca aatgtttttt aaatggaaaa tctggatgtg ccatggagtt 420ttacaaatcc aggtatttag gtgtatttat ggaacttgtt ctttggcttc ctgtttttta 480aaaattatag tgtaaagttc atagagatct gaacttcatt ccttctatga atgactgctc 540atggagtctg gtaacatgca aaagtttcag tgtttgctac catccttgtt gttaccacc 599189599DNAHomo sapiens 189ccttcttatc ctccttcttc ctcatgtata gagaccatat aagacagttt gctggacaat 60tctggtttgt gcctatagct ttgcataatt atcattatta ttcattcccc aaagtgtcct 120ggtttagata atttcatggt caccttaacg ttcataactg aaagtgtcaa gggtgttgta 180ttgcaggtgc ccactaggtg tcagcagtgt gacctccaga gaaccctcag agaaaggatt 240tcattacaaa agtcaaatca aagcaaataa ttaagtgtag ttccagagct acctgaagcy 300gtggtcattc aaaacaaatg agaggacagg gggaggagag aaggaacaag cgcagatcag 360gtagctcctt cttgggatct gatagacagg gaaggtttcc tttcctcatt agaaggactc 420cagtgatctg tggaatgagc actacagtat ccttttaaat tttcacccac aagacaaagc 480cagtatgcag tgaaatgagg aaatgccttt aagtgaagag atttttattt ctttcataaa 540ttgctcaagc catgattgga tggaggtcct ccaggtagct ccatggactt taacaagtc 599190599DNAHomo sapiens 190tccttttaaa ttttcaccca caagacaaag ccagtatgca gtgaaatgag gaaatgcctt 60taagtgaaga gatttttatt tctttcataa attgctcaag ccatgattgg atggaggtcc 120tccaggtagc tccatggact ttaacaagtc tattgaataa ctgcatttga gttggaagct 180gagttgcctg aacacaaacg atttaaacca gattagaaag tgtctacata cagagctcaa 240taacacactc ggaatcttct tgggaggacc cacagactgt acctatatta cttttgaccy 300aggtggatgc agtcactctc tagaagcctc cccgacttca gatgtgtggc acacatccac 360acaggggtgt aggtaggaga agcccacagg aatggctctg cagatgttcg tgacttacag 420tccttggaat tgtttgctac tgctagtggc tcttgagtgt tctgaagcat cttctgattt 480gaatgaatct gcaaattcca ctgctcagta tgcatctaac gcttggtttg ctgctgccag 540ctcagagcca gaggaaggga tatctgtttt tgaactggat tatgactatg tgcaaattc 599191599DNAHomo sapiens 191taattatctc aaatgctaag cacaatgcct cctttgcctc agctataaac tttatgctat 60ttgagtatgt agattgcctt attgagatag aatcaatgaa acattttaat tctcatttat 120ttatatgtgt atgttttctc taggatgggt gtgtaatgtg ggttgagcct tgaggtctgg 180cagttacctt ctgtgtgctc tggctattca cttagctccc tccctgtggg tgtggggaca 240ctggtatagg tgtccccttt agactctcct ttatagttgc tattcatttt gagctagtar 300agtgtgaata ttaaatagga atgttagttt gaagaagtct tgtgcaattt gcttagtgaa 360taagttacac aaaggatctt actatatttt taagaggtat acaagtaaaa atggctttcc 420aaatggataa cattctcagt tcagaacagt ctaacatctt ttgtgaaatc atatagacac 480tgattgtgtt caaggtgatc ttacttggta cttgagtttt ccttttaaaa caatatgcta 540gagattctgt gttccctgct ccccattcca caacctggct tcctcttcac agaaatggc 599192599DNAHomo sapiens 192cagaagcgtg catcggctga ctgtacattt tctcttacgg aacactggaa tggtgaggag 60aaatgatact gaaaaattgc ggcttcttct tttctatctg attgaaagtc ttggtgttca 120gggttgggaa ggatacattg ttcgtgttaa cacgcctggt ctgcttactt aggaaaatgg 180cagcattctt tgtgtgttcg ctcgtgaagt ttctggatga gtatggaaga tgctgactct 240ggctcgagga gctttaaagg gaaataagaa tacatgcacg cctgtgtgca acagccctgr 300ccctagtttc tctgtatcct gttgcccagg tttgctttct tctgagctgt ctatcactct 360ctgacatctg attatttatg tgtgagttgg ctgttcactc gctgtccatc cctcctcaag 420agaggttcca aggacatggg tgtcttttta caaatgtcac ttacaacgta tatagttaaa 480accaagtaac actgttttat attttcaatc atttcacaat gtaatttgta atctgctttg 540aacctcagaa gagtctgtat cttattttgt tttgttttgt gttacaactg acattcatt 599193599DNAHomo sapiens 193ctttctgccc accctgatcc tctctctctt tgcccgcagc ccgcctgacc ggaggccaga 60tgtgccgccc acacttgttg cacagcccgg gtttgccctg gctggacggg ggcaaagcag 120ccctctctgc cgctgcggcc caccaccaca acccctggac cgtgagcccc ttctccaaga 180cgccactgca cccctcagct gctggaggcc ctggaggccc actctctgtg tacccagggg 240ctgggggtgg gagcggggga ggcagcggga gctcagtggc ctccctcacc cctacagcar 300cccactctgg ctcccacctt ttcggcttcc cacccacgcc acccaaagaa gtgtctcctg 360accctagcac cacgggggct gcgtctccag cctcatcttc cgcggggggt agtgcagccc 420gaggagagga caaggacggc gtcaagtacc aggtgtcact gacggagagc atgaagatgg 480aaagtggcag

tcccctgcgc ccaggcctag ctactatggg cacccagcct gctacacacc 540accccatccc cacctacccc tcctatgtgc cggcggctgc ccacgactac agcagcgga 599194599DNAHomo sapiens 194gcaggcaagc ctgagaggcc ggtctccagg ctttgcagct cccggcaaga ggtcccagag 60gtcttgccct tccagagatg aatgcttgag gcccagaaca tggggccatc cggagccaag 120gcctgggatg ttagaggagg ggaactcggg actccatgca aggaccacgg gtcagccctg 180tgcctgtcca gaccacctgc atgggacaca gcaggggccc agaactgggc atccagtgga 240tcactgcagc agcatctgtg tgtccatatc caggtagccg cacccagatt ttccctccar 300ggaccacccc ctcccactct cagttcaagg tggtccatgt ggagcaccca cctctggccc 360agccagtcag agccatcctg gctgattgat tctgggcaca tgactctgga ggatccatgg 420agagtccaac ctggaaactt ggcaagaatc ctcggggact gccctcctgc tggggtcatg 480tggcactggg agctgcggtg gccatcttta ctgccaccca ggagagcctg ccggagagtg 540agaccaacac agagcagcag agacagagac agactggctc ccgagcgttc agccccagt 599195599DNAHomo sapiens 195ctatataatc cacagacctg tgacatggcc ttacaccagc cagatactca ggaaatgttt 60acaggggaat gttaggcatg acctatcagg gcactgcatt tctctcaagg cacagcgatt 120ggttcagaga tggccaaacc caagtcactc aagccaatta aagtgagtcc caggactttt 180gcttggacag ctggaaaaga tattaatttt cccacttacc tctttaacag tggggagtat 240gaagccagaa ctgctgcagt tagtttgcca caccagagga gaggcttcct gagaatggar 300tcatgcagag caagcagacc ccagagacag atagaaagca aacaaggttt tcacagcatc 360atttaagccc ccggatcaaa ccatacctaa agaccaccct tagatttttt ttctgttaca 420tgcagcaaca cctcctttct ccccaacctt tttttttatt ttaaagagag tttggatccc 480tactgctgca atgaataaca gaagggcatt tggtaaatga ttcaacccta gacatgtgtt 540tgaaatcact cctgccggat aggtgagcaa aactgctgac ggctagtccc ggttttgct 599196599DNAHomo sapiens 196cagatagaaa gcaaacaagg ttttcacagc atcatttaag cccccggatc aaaccatacc 60taaagaccac ccttagattt tttttctgtt acatgcagca acacctcctt tctccccaac 120cttttttttt attttaaaga gagtttggat ccctactgct gcaatgaata acagaagggc 180atttggtaaa tgattcaacc ctagacatgt gtttgaaatc actcctgccg gataggtgag 240caaaactgct gacggctagt cccggttttg ctccgcctag acatggtgtg gtaaaggcam 300acctttgcta tgggagttat aaggcaatca gaaggtttcc tctttccaaa aatgtcctag 360acatcttcca aagtagagta attcacaagt gtttatacca aaggcaaact ctccatccaa 420tgttctatct cctgagtggg gatgtcctcg ccagaaagcc tcagttagac gctggtcttt 480cacacttgtc tgtaatggcc aaccactctc tccttcagcc cgacagtgcc tttcttggtt 540taagccagtg caaacaatgc tccaacacgg gcagccggat gggagaggct ggacgggaa 599197599DNAHomo sapiens 197ccttttggag tccccagtgt ctgttctcat tttcatgtcc atgtgtaccc aagatttagc 60ttccacctgt aagtgagaac atgaggtatt tggctttcta tttctgcatt aattcattta 120tgataatagc ttccagctgc agccatgttg ctgcaaagga catgattttg ttctttttta 180tggcttcata gtgttccatg gtgtacatgt gccacatttt ctttatccaa tccactgctg 240atggattgac tttcaagttg attttatgac tttcctattg tgaataggac aagttaaaty 300ctaatttatg cacaacttat atactgaaca tggttataca gtttgcttgc agacgttgaa 360taagtaacca ggggaagcat agggtggaat ggaactaaat gtgcttaggg acttataatt 420ccagggagtt cagaaaaact ttcctgagga actaatgttt aagctgaaac ctaaaagata 480atgaagcctg tttcttctgt cctttttctt gtgttttcaa tcacacccca tcttctcatt 540tgcctggtga tttttaattg cgtgccagac attgtctatg aaaacctata gagataata 599198599DNAHomo sapiens 198ccagtgtctg ttctcatttt catgtccatg tgtacccaag atttagcttc cacctgtaag 60tgagaacatg aggtatttgg ctttctattt ctgcattaat tcatttatga taatagcttc 120cagctgcagc catgttgctg caaaggacat gattttgttc ttttttatgg cttcatagtg 180ttccatggtg tacatgtgcc acattttctt tatccaatcc actgctgatg gattgacttt 240caagttgatt ttatgacttt cctattgtga ataggacaag ttaaatccta atttatgcam 300aacttatata ctgaacatgg ttatacagtt tgcttgcaga cgttgaataa gtaaccaggg 360gaagcatagg gtggaatgga actaaatgtg cttagggact tataattcca gggagttcag 420aaaaactttc ctgaggaact aatgtttaag ctgaaaccta aaagataatg aagcctgttt 480cttctgtcct ttttcttgtg ttttcaatca caccccatct tctcatttgc ctggtgattt 540ttaattgcgt gccagacatt gtctatgaaa acctatagag ataatataaa gttctgaat 599199599DNAHomo sapiens 199aaattcagtg gtgcttaata tattcatgga tttatgcaag catttctaaa tcaattttag 60aatgttttca tagctcaaaa aaaaaattca catcctttaa ctatcacccc tcttatcacc 120cccatatgcc ctacctctaa gcaaccacta atctactttc tgtccctata atttgcctat 180tctagacatt caataaaaat gggattatat tctttttgtg actagctctt tttgtggtct 240ttctgtgact agctctttca cttagcataa tgttttcaag ttttatccaa gtagtaacaw 300gcgccagtat tcctttctct ttatgactga ataatattct agtctatggc tatatcacat 360tttatttacc catttatcag ttgatggaca tttgggttgt ttctaccttt tggatattat 420gaatagtgct tctgtgaaca tttgtgtaca agttttaatg taaacatgtg tttccacttc 480tcttgggtag atacccaaga gtaaaatttc taagtcatag ggtaactcca cgcttgacca 540tttgaagaac tgccagactg ttttctaaag tgactgtacc attttatatt cccaccagc 599200599DNAHomo sapiens 200tcggctcact gcaacctcca cctcctgggt tggagcaatt ttcctgcctc agcctcccaa 60gtagctggaa ctacaggtgt gcgccaccat acccagctaa tttttgtatt tttagtagag 120acggagtttc accgggttgg ccaggatggt ctcgatctct tgacctcgtg attcacctgc 180ctcggcctcc caaagtgctg ggattacatg tgtaagccac cacacccggc ctgtagagag 240ttttaaaatc aggacgtgta agtcctccta ctttgttctt ctttttaaga attgtttttr 300gctattcttg atcccccaca attccatatg aatcttagaa ccagattttc tattttacca 360ttaaaagaat tcagctgtga ttctgacaga gactttgttg aatctgtaca tcaatttggg 420gaatattgtc attttaacaa tattaagact tctgatccat gcatatggga tgttcttcca 480tttatttcta tttccttttt tttttttttt tttttttttt tttttttttt ttttgagatg 540tagcttcgct cttgttgccc aggctggagt gcaatggctc aatctcggct gactgcaac 599201599DNAHomo sapiens 201gtataatgtt aaatagaagt ggcaagagtg ggtatccttg ccttgtgtct gatcctagag 60aaaaagtatc cagtctttca tgattcagta tgatgttagc agtaggtgtt ttgtagatgt 120cctttatcag gttgaggaag ttcccttcta ctacaggttt gatgaatgtt tttattatga 180aatgttgttg gattttgtca aatgcttttt tctgcatcta ttgagatgat catttggttt 240tgtccttcat tctgttgata tggtgtattg cactgattga tttttaaatg ttgactaacy 300ttacattctt gaataaatac cccttggtta tagtgtataa tttgttatat atgttgctgg 360attgagtctg ccagtatttt gtgtaggagt tttgcattca taatcatgag atattggtct 420gtagttttct tctcgtgtaa tttttttgtc tggttttggt atcagtgtac tgctggcatc 480atagaaagag ttgggaattg ttctctcatc ttcttttttt ttggagaaaa agttgtgaaa 540ttctttaaat ttttggtaga attcaccaga agtcatctgg ccctgagttt ctctttggg 599202599DNAHomo sapiens 202gaattagttt tggtagtttg tgcctttcta ggaatttgcc cacttcatct aggttaccta 60attttattag catataattg atcacagttt tcatttataa tcatttttat ttctgtaagt 120tcagtagtaa cattccctca ttcattcctg attctaaata ttgagtcttt tctgtctttt 180acttattcag tccagctaaa agtctatttt acatgaatta gtatagccaa tccagccctc 240ttgtgtttgc tgtttgcata atatatcctt ttccaattct ttttttcagt ctatttgtay 300ctgtaactcc aaattgtggc tcctttagac aaggtatagt tgggtcttgt ttgtttttcc 360cgtgtgacaa tctctgactt ttgactagat tgtttaatcc atttacatat aatgttatta 420ttgatataat cggatctact tctgctattt tacttttttt tctctgtcta ctgtcttttt 480tgttcctcta ttcctacttt actccttccc tttgcattaa atattttcta atttagcctt 540taaatttatg taatgttatt ttcaatatat tcttttgagg tatttcctta gtggttgat 599203599DNAHomo sapiens 203gcttaccttt cccagtgtgg atccttcatc ccacaggaca gggggtgagc agtaggggcc 60ccaggattct cggtggttct gtgccctgta ctgagccttt gtcctacaag tggggggtgc 120tgggcagaag gaagcctcca cttctgagat gcacttgccc ggaatttagc ctcagcaaca 180ggtagctgtg ggcagaatga gaaaaatctg aagatctgcc cctcccagga ggataaccct 240tcaacagaaa gctgcagggt ggcgggggaa ggagtcctgt gtcctcgact atactagcay 300gatgcagggt ttcactatct cactgagctg ggagcaaggg gaaagagggt cttggtccaa 360ataccacaga ctgagtttta ggagatttgc ttgaataaat atttcttcat ttgccatatg 420ttcttaggac catttccaga gtgattgttt tagaataact ttttaccagt tttgattgca 480gctgggtcca tagagctcct catgctgtca ggccagaagt acaaacttgc ttccagggtg 540tagtgccctt tggggtctga acctggggat tttatcaagg cccctgcttc tgggcagtt 599204599DNAHomo sapiens 204aatgaacaca ttccctctcc taacaccttc tcatagcact caaggacttt accatccgag 60tcccccacct ttgcagcttc atgttggctt ctatatttgt ccactttcct gactacaaag 120ttctttcatg tactttgtcc catgaaattc tcccaagatc cctctcgctt aggatttttt 180ttaatcccca ttttacaggt ggggaaatca aggcaaggca aagttaagac tcaaccaaga 240tgccccaact agtaagtggc agagcctctg ctcgcttcac ctaggcctgt taacaccacr 300tcttgagttc tagtcacgac tctaagctgc ctttctcatg aacctatgcc cctaatatag 360gctttatttt tgcccgccac actgtgccta tcctcaaaca ttgccgagaa aagccctttc 420ctcatctcca ctttcacaaa tctcctctat cctgaattca gtgtaggctc aaacatcact 480tcaaaaataa gacagtacca gatgttcttg gcctcagtga ttggatcgtt ggtgatcaca 540agacacacac tagaccaatt agagtaaatt ctggaacttt tgctggaatc actggaaaa 599205599DNAHomo sapiens 205ccttccacct gcccattaac tcctgaaagt tcctccatga ggagatccac aaggacctgc 60tagtgatggg tgcgtacgag atctccaaca agtctggggg tgctggcagc ctgcacagcc 120acctcaaggt cacagattct gctggccaca ttctctactc caaagaggat gcaaccaaag 180ggaaatttgc ctttatcctg gaagattatg acatgtttga agtgtgattt gagagcaagg 240aaacagggtg gatacctgat caattcgtaa tcctagacat gaagcatgga gtagaggcar 300aaaagaaatt acaaggagat tacaaaagtc gagaagctta aaccgttata gatggagctg 360caatgcctag aagacctgtc agaatctatt gttaatgatt ttgctacgtg aagaagagag 420agatgtgtag tactaatgaa tcaacaaaca cttgagccct gtacttcagt gtctctttaa 480tgttctgctt cattggacta gccacctggc aggttttcta cctgtgttgc ttcttcaagg 540ccaagatgtc gattgagtaa tgaacgaagt gcactctcct cccaccttgt atctcaggc 599206599DNAHomo sapiens 206tcctgctcgg accttaccct caaggaatgc agaaccccct gtgtatccct ttctcctcct 60gatatagttt agatatttat ccccaccaaa tcttcatgtt gaattgtaat cccagtgttg 120cagatggggc ctggtgggag gagttttggt catgggggtg gacccctcat ggcttggtgc 180tgtcctcact gtagtaagtt ctcacaagat ctaattgttt aggtgtgtgc cacctacccc 240ctcccactct ctctctcttt tgctcctgct tttgctatat gaggtacctg atcctgctty 300accgtccacc atgactgtaa gcttcttgag gcctccccag aagccaagca gatgccagca 360ccatgcttgt acagcctgca gaaccatgaa ccaattaaac ctcttttctt tataaattac 420ccagtctcag gtatttcttt ataacaatgc aagaaaagct gaatatacct ccccactgga 480gcactagccc cagacctgtc acaagtcaga tgtcacatat gcttatagag acaagaaaga 540ggacatggaa gtcccagagg ggctgcaggt agtatcctgg caagggttga gctctggaa 599207599DNAHomo sapiens 207gacttcactg gggctgggct ccaggggcag aaggaaaggg aagagcaagc aagccccaat 60gcacaaggtc tttgaaagcc ttgccctgca tcacctttcc tactgttcca tttttccaaa 120gcaggtcaca cgtccaaacc cagagacaag gtgtggagca atagactcca cctgggaaga 180gctgcagagt gcggtggatg agaggagaag tattcatggc cattgttaca atttattcag 240ggagctcatt tcaatgggga catctcccac tatcatcgct ggcctgcaaa gaatagtcaw 300ggcacagcct ttcaagatgc ccatgcttcc ctcaccaatg tgttacccaa agctttggtc 360cagaaaacat cgtctgaact cctcacccca gggatcatgg ttaggtggta gatgagtatt 420tgactgctca aatctcaata acttccagag ccctagctgt gagggagtcc agaaaaggta 480ctttgtatcc ttccagcctc tgcagtacag gaaggacccc aaaaggtggt gacatggatg 540ctgagcacca gtccaacatg tccgcccacg ctgaggagct tcatgaggag ggaggtgag 599208599DNAHomo sapiens 208acacgagtgg atcacctgag gtctggagtt caagaccagc ctggccaaca tggcaaaacc 60ccgtctctac taaaaataca aaaaaaaaaa aaaattagca gggcgtggtg acaggcacct 120gtaatcccag ctacttagga ggctgaggca ggagaatcgc ttgaaccagg aggcagaggt 180ttcagtgagt agagatcgag ccactgcact ccagattggg tgacaagagt gagactcgat 240ctcaaaaaaa aaaaaaaagg aagtgaatga agagcaaaag gagaccactg tgggcaactr 300agaacacagt ccaggcagag cgaacagagg gcaaagccct tggtgtggta aggaaatcac 360tgtgtccagg gagcagacac agctacatgc cccggtgtgg ccgtgtggct tgaagctgag 420taagcaagag aggaagggag gaacaggctc acagaggagc tggagaggtc acagaagctc 480cctgatgacc agagcctctg ttcagccaga acactccagt ggaacacctt gtgtccacta 540acgaggcctt gccactaatt tggcaaagaa gtaaataatg tgttaaaact cagatgtcc 599209599DNAHomo sapiens 209atttaaacaa acaggaattt atttttctca cgtgagaaat ctaaggtgct gttcaatggc 60tgaggcatgc ccggctgaaa ctgctgtcag tctctttcct catggtcaca agatggctgc 120cttagctcct gccattagat ccatgttcaa agcaaggaga aagaggaaag gggaagggtt 180gcaccagctg agtccctctc tttctgtcag gaaagaaagg ctttttaaaa gctatgccca 240gaagatatct gctaatatat catgggtcaa aaatgagcca catgccaccc ctagctatar 300tgaagtctgg gaagtatttg gctgtcagcc tctatagtga aaggcaccaa gggagcagag 360ggctggggac agatgctggg acaacctacg cagcagctat ctggcattga tgctgtgggt 420cacccaaggc cccaccccat ctggctccac cgtgcaatga gccaccagcc acccgcacac 480agctgtgctc agtgctagaa ccaatgagag ctcagcccgc aataccagga gcgttcttca 540aactccaggc aggcctctaa aattatctcc aggcttctgg tgagggttac agggcaact 599210599DNAHomo sapiens 210caagaaacct gaccaaggca gactcacccg cgcaggcgct gagtcatgtt gacagcaggt 60gcccttgcta ggatgtgatg ggcagggcgc ttacctctgc gggcatcctc ccccaacaaa 120caatcccggt ctaaccagga gaaaaacacc tgttttttcc gacagaggga catgctatag 180aatgcctgac tgtactgccc cgaactgtca aggccatcca aaacatggaa agtctgagaa 240actgtcacag ccaagagaag agcctaaggg gaagactaaa tgcgatgggg agccctgcay 300gggatcctgg ggccactggg taaaatgggg aagcctgaat gaggcatgga cttcagttac 360actgcatcgg cctcggctgg ctcaaccgca ccacagtaag agaagacatt aacaccaggg 420gaaactaggt gtggcgtcta tgggaactct ctgtaccatc gctgcaactt ttctgtaaat 480ctaaaagtgc tctaaaataa gaagtttatc taaacataag tgaaaggcag ctgaaaactc 540tgaatgcagc acacagaaac aggtccagca cagcaaggag acggaaacta tggaaaaga 599211599DNAHomo sapiens 211cacggtgaaa tcccgtctct actaaaaata caaaaaatta gccaggcgtg gtggcgggcg 60cctgtagtcc cagctactcg ggaggctgag gcaggagaat ggtgtgaacc tgggaggcgg 120agcttgcagt gagccaagat cgcgccactg cactccagcc tgggcgacag agcgagactc 180cgtctcaaaa aaaaaaaaaa aagaaaatat aaattctcca aatggagaag caaaaatccc 240gaacctgata aataaaacta aagcaacacc tggatacgtc gcagcgaaac tgcagaccay 300cacacacaga gagaactgtg gcagacgctg tggcacccag agccccccag gacagagacc 360tggtccccag tggcagcagg gctggcggcc tggctctcgg ctatgtccct ctccaggaac 420tgctgccagc tgaatacagc tgcctctccc cacttccccg tgggtgcagc tggcatggaa 480tgactggtcc aagtggggac ccaaaagccc agctccggag ttcccacggg gtccaccgag 540ggctatgccg atgctgctac ctttgctccc tcagaggcac tgtccccaag aacacaccc 599212599DNAHomo sapiens 212tatattaata ataattttta aagtaccaag tagcataggg tttataataa aaagcattgg 60ccccaatccc tctccctggg agcagacagc cttaattagt tcatctccat acatttaaat 120actaagccta aaactaccat tatttcatgt atcaacttaa atcatgctct gttgactgcc 180taccaggaca gccaagctgg acagtcagtt aaaacctagc tgccgccacc tgcacctccc 240ccagttttat ttaatgtgtt tagttcctcc attgcagagt tatcaaccct cagtcattcy 300tgtgccactt ttgcaatttt tgctttatct ctctagtgcc tacctgcatt accatttact 360tactacttat ttttttaatt gatttgcttt gttaaatgaa agtactttaa aagaaagcat 420ttacttcact atcattcttt aaatcttatg ctaagacaca tttaaactag tatcactgcc 480cactgatatc ccacctgaaa cccttgtaag cacccttccc acactttcaa ctttaaatca 540tatacttaaa ccttactgcc tccgtgtatt ttgacatctc tgggggagac agctgcttc 599213599DNAHomo sapiens 213agcatagggt ttataataaa aagcattggc cccaatccct ctccctggga gcagacagcc 60ttaattagtt catctccata catttaaata ctaagcctaa aactaccatt atttcatgta 120tcaacttaaa tcatgctctg ttgactgcct accaggacag ccaagctgga cagtcagtta 180aaacctagct gccgccacct gcacctcccc cagttttatt taatgtgttt agttcctcca 240ttgcagagtt atcaaccctc agtcattctt gtgccacttt tgcaattttt gctttatcts 300tctagtgcct acctgcatta ccatttactt actacttatt tttttaattg atttgctttg 360ttaaatgaaa gtactttaaa agaaagcatt tacttcacta tcattcttta aatcttatgc 420taagacacat ttaaactagt atcactgccc actgatatcc cacctgaaac ccttgtaagc 480acccttccca cactttcaac tttaaatcat atacttaaac cttactgcct ccgtgtattt 540tgacatctct gggggagaca gctgcttctc tccccaacct tcccaacctg ctcctccct 599214599DNAHomo sapiens 214atctccatac atttaaatac taagcctaaa actaccatta tttcatgtat caacttaaat 60catgctctgt tgactgccta ccaggacagc caagctggac agtcagttaa aacctagctg 120ccgccacctg cacctccccc agttttattt aatgtgttta gttcctccat tgcagagtta 180tcaaccctca gtcattcttg tgccactttt gcaatttttg ctttatctct ctagtgccta 240cctgcattac catttactta ctacttattt ttttaattga tttgctttgt taaatgaaar 300tactttaaaa gaaagcattt acttcactat cattctttaa atcttatgct aagacacatt 360taaactagta tcactgccca ctgatatccc acctgaaacc cttgtaagca cccttcccac 420actttcaact ttaaatcata tacttaaacc ttactgcctc cgtgtatttt gacatctctg 480ggggagacag ctgcttctct ccccaacctt cccaacctgc tcctccctca gatctcctac 540cttggttgac agcaattcca tccttcccat cattcaggcc aaagcctcag agtcaccct 599215599DNAHomo sapiens 215agttggagga ctgagtccca gggccctcca aattccagca gcccagagat gagaaaggac 60cagctttaaa ggtggattca gagataccag caaaggagag gagatacagc gtgtgctgat 120aaacctgccc tctgaaaata aagaaataaa cgcattgatt tgtagagttt tccagtttcc 180atggtgtaaa taactcccac tgtggtccat ttcaggctac caacatgacg tcactgaaca 240gggagtcagg agctttgcac atagtcaact cttgcaaact attatgagtt tgtcctgcty 300cccactgcct ggaaaccaag caaacagaga gttacaaaaa aagaattaca agcatgaagg 360gtgaacaacc atgttaaatg ccgttgacat gtcaaattag ctgaggactt ccgcagtgat 420ggatgtaaca ctttgccacg caaaaatgtt aaacgtagat caggcaggat gcaaaaatag 480cataacttca cactctgtaa agttacactc cccagtacaa ctttcaaacc ggagcaataa 540agagagaaac aattccctgg atcatttatt tttaatctct cctcaattct aacatatgc 599216599DNAHomo sapiens 216ggtgtaaata actcccactg tggtccattt caggctacca acatgacgtc actgaacagg 60gagtcaggag ctttgcacat agtcaactct tgcaaactat tatgagtttg tcctgctccc 120cactgcctgg aaaccaagca aacagagagt tacaaaaaaa gaattacaag catgaagggt 180gaacaaccat gttaaatgcc gttgacatgt caaattagct gaggacttcc gcagtgatgg 240atgtaacact ttgccacgca aaaatgttaa acgtagatca ggcaggatgc aaaaatagcr 300taacttcaca ctctgtaaag ttacactccc cagtacaact ttcaaaccgg agcaataaag 360agagaaacaa ttccctggat catttatttt taatctctcc tcaattctaa catatgcatt 420caggccataa ttgtccctct aagcatggct ttaactgcat tccaacgttt gtacatgtaa 480tattttaatt atcgtttgtt caaaacataa ttttaattgc catcacgctt tttctcaggc 540ctgagagttt tttaagactg ctgttcggcc gggcatggtg gctcacacct gtaatccca 599217599DNAHomo sapiens 217ctcaaggaaa aagtgacccc aaatgctgag ctcacctttc cccatgtttc ctttgcgtgg 60atcttcatcc caccgtcagc tctccagtgc cttccggcag gccttcgact ggactgtttt 120gtgcagctcc tctgggcgtc ctcagtggaa gggctgctac aaaccaccta gtgcctttgc 180aaaaatcaaa agtctcacct catttttcaa aggaaaaaga caagcttttc actccacgga 240aggagtctcc cctttccatt cctaaagaga tctctaccat gatgttatat caggaatgtr 300atgagaatct gagggaaaag gtctgcgact atggactcct aaaggcaggc agtattaaga 360acagagttgg caactcgcag cagccaaaat gctaatacag aattctgttt ccaccaaaaa 420aaaaaaaaaa

aaaaaggcca gacatggtga ttcacgcctg taattccaac atattagggg 480gctgaggccg gaggatcact tgagctcagg aattcgagac caacctggtc aatatagtga 540gacctcatct ctataaaaaa attaaaaatt aattgaatat agtggtacac acctgtagt 599218599DNAHomo sapiens 218ccgttaaatc ttccgagcac ataggcaaga tagaaacacc actgccactt ggtgacagtg 60tgctttaatt gcagggaatg ggaaacaaag gcccaaaagc aagtcacaga ttagaacagc 120atcaccacag gaggtctgag agccaagcct ctgcctcaaa atctgacagg gaaggaacaa 180tctagaagac agattctgaa gacattctgg aaaagagaga ctgagtacag tacaacccct 240ggtcctttct tccttctgcc ctaggcccca gctcagccca tctgctcacc ttccctatcy 300ctagttctca cggtagggaa cagcttattt acaaagggaa ctctaaggtc tcaggaggaa 360ttttggtcaa tattttagcc acttcctaca ttcagcctcg ctcaaggtct ctcttcttga 420ttgtattgtc ctaatctact ttcccaccaa cataaatagt atttctagct cttgtcctaa 480ctgagagaaa gtttgtgttg gaattgctac tgggaaatct ctagtgactc ttcatgttaa 540aagaggagga aggggctggg catggtggct cacacctgtc atcttagcac tttgggagg 599219599DNAHomo sapiens 219aaaaagtgag actccatctc aaacaaaaca aaacaaaaca aaacaaaaca aaacaataaa 60atttaccacc ataaccattt taaagtatag agttcattgg catgagatac aatcatattg 120ctgtgcaaca ctcaccactg ttcatctcca gaatgttttt cattgtccca aactgaaatt 180ctgcacccat taaacactaa ctccccattc tccctcctcc agcccccggc aaccaccttc 240tacttctctg tgtctgtgaa tgtgactgct ggggatctta tatgaataga atcatgcagr 300acttgacttt gtgtgcctgg cttatttcac tcagcatcat gtcctccagg ttcaccgatg 360tggcagcaga gctcagaacc tccttccttt ttaaggctgt gtaatagtcc attgtgggac 420aggctgcatt catttatcca ttcatctgta gatggacact tgagtttctc ccaccttttg 480gctattgtga ctttggctta ttttaacatt atataaaatg aggccaggca tggtagctcc 540tacctgtaat cccagcactt tgggaggctg aggtgggagg attgcttgag cctaggagg 599220599DNAHomo sapiens 220cagggcatac tgactgtgat agacacgtcc tcatcctcac aggccgacag tccagtggga 60agatcaggct ttagtgaaac cactgcaaat atctcattgc aaaacaaaat agctgcctta 120gaaagttgtg atcaggtggt ttttccgact tttttttttt ttttagcagc agaacccttc 180attcaaatga agccttaccc aggactgggt catggaaaat agctgaaagc aaagttgctc 240agaggctctg tggctgtcac cagagagccc gacggcttca aggaacacag ctggaaaccr 300gagcttgatg tctgggaggg aggggtgagg aaaggcccac agtggcacag cagagtcctg 360gcacattgtg ggcactggag aagccatccc tgcctgagct cgtcatctct ctctctctct 420ctcaccatgt caaatggtag tgggtgggta cagggcccaa actcggtccc cagacccccg 480agtgtctctg gtgccagaga ccccacaatg cctagaagct tccaaccacc ctggcccagg 540gtgcctaggg gctgagagtc tgggggtccc tggaggcggg agacgctgag tctaggcag 599221599DNAHomo sapiens 221cgtggtaggg gcttcaagaa tacgcatcaa atgaacccga acccaaggac gcttgctcac 60ctgtgtcatc tgggggtctc cttccacagg aagcacatct gggcagagtg aaggctccca 120gggctcaggt ccagaaagag ctggaggctc ctgagagcaa ggggccctac tcggccatga 180gcccagaaca atgcgagctt cacacaccgc aggtgtgtgc gtgtgggagc ctcttcctga 240agccttgggg tcaggggccg gggcccagca ggctgggttt attgtccatt gtctcaggcy 300gggacaggaa gcactttctg ttcccaattg ctcgggtgga ttaatttaca gtggggagct 360cagagtcgcc cacggcacct gttttcccct ctgaggggcc agcttccagc ttggagggtg 420tttcaggagg ggtctcctct gcagagacgt ggcctcctcc agagaccctt ggccacagcc 480cctgcccgct ccgtgctggg ccgaggccaa ggccctggca gccctgcctg cttgcccggg 540tcacgctgcc cacccacggg gaaagctgag ccctgtggag tgcacaccat gctgtcagc 599222599DNAHomo sapiens 222cctgcttgca gggtcttagg tctattgtcc cattactcct gacaaggtag ttgctatgag 60tccccccact ccaaagatgg aaaagctgag gcacacagag ggtaagtcat ctgccaaagg 120tcattgagcc aggaggttgg ccagggagat ctctgctcac cgagttggga ctgaggagtg 180gcaaggggga gagtagtgtt tagggagacc cactgcgtgc ctgccaccag gctaagtgcc 240ctctgcacta agctactctc atcctcgagc aatattaaga ggctggcatc gtgcacccar 300ttttagagat gaagaagcag ggcctccggg accagaagcc tcagctcaca caggattgag 360tgcagagcta aggctagagc ctgtctgcct ggctgcaggg cctaacccct ggagagagaa 420gacaacatca ccctgctggt gctgtcctct cagccccctc catgccctgg gcactggggc 480cggatgccca gcagggggtg gtggccttgg ccctgggcag acattctaga aagccagcag 540ttcattaggt cccctgctcc aaaacacaag ggccatgctt gagactcatg ggtgagggc 599223599DNAHomo sapiens 223cagtagtagc agttcaaagt cacaacaaaa ttttgaacca aagacaaaag caattatctt 60taagagatca ccttttcctt tttgagatgg agtctcactc tatcactcag gctggagtgc 120aatggtgcga tctcggctca ccacaacctc cacctcttgg gttcaagcga ttctcctgcc 180tcaacctccc gaatagctgg gattacctat tagaatgttt ttaacttttg ttccattgtt 240gaacatttac actgttttac actcttgcta tttataaaca gccctgagag aaacagctas 300atatctgtct tagaagactt aaattatttt tttctttttt tgagacagag tgttgctctg 360tcgcccaggc tggagtgcag tggcatgatc tcagctcact gcaacttcca cctcccaggt 420tcaagagatt ctattgcctc agcctcccga gtagctggga ctactggcac ctgccaccat 480gtcctgttaa taaaagactt aaattactat attaaaggtg atctcttggc tgggtgcagt 540ggctcatgcc tgtaatccca gcactttggg aggccaagtc aggtgaattt cctgaggtc 599224599DNAHomo sapiens 224agatgtcatg gcaccactgc actccagctt gggtgacaga gcaagaccct gtctaaaaaa 60aaaaaaaatg cttctatgtc ttttgttttt agcactaaat aacattacat tggattttcc 120acaggaactt atccattcac ctactgaaag acatcttggt tgcttccaag ttttggcaat 180tatgaataaa tgaatacaca tccatgtgca ggtttttgtg tgacacaaat tttcaactcc 240tttgggtgaa taccaaggag tacaattgta tgaattgtat ggtaagggta tgtttagtty 300agtatgaaac tgccaaactg tcttccaaag tggctgtgcc attttacatt cccatcaaca 360atgaatgaga gttaatgttg ctccacatcc tcgtcagcac ttgggccatt ctaataggtg 420tccagtggta tctcattgtt ttaatttgca ttcccctgat gatagatgat aggaaggatc 480tttcttctgc ttgatttgct gtctgtagac cttctttgct aaggtgtcta ttaaggtctt 540tagcccactt tttttttttt tttttttttg agacaaggtc tcgctctgtc acccaggct 599225599DNAHomo sapiens 225tgacccctta atttacaaga tactaagggc tccttaccca acccccttcc gcaaggagtt 60aacctgtgta agcagatcct cagcatttca aagtagccca attaactgat aaggtactag 120caccaacaat gtatgaagtt cccaggattt ttctcaaaga gataacaaca taaagccttg 180agttcctgtc cggcataccc cctatatcta attataataa aggtttaaag ccttgcacct 240ggtaccgttg ctcttcttgt aaccatttgt cttttaaatt gtttatctct ttgtaaccaw 300ttttttttta ttcttgcatg tttttacttc tgtagaatta ttgcatttga gttcccctcc 360ccttcctaaa cctaggtata aaagttaatc aacccccttc ctcggggcca agagaatttt 420gagcgttagc cgtctctttg gccgccggct taataaagga ctcttaaatc gtctcaaagt 480gtggcgttct ctctaacacc cctgggcaca acaagaggtt gtggtgagcg aaggtcacgc 540cactgcactc cagcctgggc aacagagtga gaccctgtct caaaaataaa taaacaaat 599226599DNAHomo sapiens 226cactgccaac agcagatatg cgggggttat ttccccacac accaaacatc gattctgcgg 60attccccagt agacatcagc tgggtgtcct ccagttcagt tctgacacca tctacctgga 120gatagtgtca gatcccacag gttgagggct ctagtcccac aaggctgccc cccacttcag 180atgctgcaag cacgggtcgt ggtctgtgct tctgaccaat tggctataaa ctggggctcc 240caggatttat ttaattggct agtgtggctc acaagactca gggaaccact tactgatgtr 300tactggtttc ttataaagga tattacaaag aatacagatg aacactgtaa tcccagcact 360ttgggaggct gagcgaggca ggcagatcac ctgaggtcag gagttggaga tcagcctggc 420caacatggca aaaccccgtc tctactaaaa acataaaaat tagctgggca tggtggcatg 480tgcctgtagt cccagctact caggaggctg aggcatgaga atcgcttgaa cctgggaggt 540aggggttgtg gtgaggcaaa attgtgccac tgcactgcag cctgggcaac agagtgaga 599227599DNAHomo sapiens 227gttcagttaa ggcaattatt tccctcatca tgtcagatag atatgaatgt tatggactga 60atgtttatgt tccaccaaaa ttcaaatgtt gaagccctaa tctcttatgt gaacgtattt 120ggaggtgggg actttgggaa gtaattaggt cctaagagtg aagccttcat gatgaaatta 180agaagagaca ccagagagat gatctctctc tccatcatgt gaggataaag caaaactaag 240gccatctgca agccaggaag agagccttca ccaggactaa gtggagtctg ccttgacctk 300ggacttccag cattcagaac tgtaagaaat aaatatctgt tgtttaagac accccattta 360tggtattttg ctatagcagc ctgagcagaa taagtcacct agcctcactc tgcaacggaa 420aaataatgac tcatgaagat tgtcactcca aaccctttgc aaaggaagat acaaatgccc 480aaggctgctc attacataat tgctcagaaa cactgtttct caggtgtaca cgatgctgca 540cacgtccact gagacaccta gtggtaggca gttctgtcta tctgaagata aaaagcaaa 599228599DNAHomo sapiens 228actatattgt tttaattatt aattctcatg gctcttttaa aatcatttat ttataaaaca 60aaatattata ggacattatc tgaatcttca gatttattcc actgcaacta gtagttgttc 120aataaatatt aaatataatt gacttacatt aagatataat gagtgtaggc aatgtgctag 180gtcctaaaca cagatacaaa tgcagatata aacatcataa taggaattca aatgcacgga 240ttggaaatta tcaagatcat tacaaaacga ttgttctcta taagaaatcc tttcaagaas 300agtaaccaac aaaaaagctc taactacaaa aatacaaaat tacatggaaa aggtaatgca 360attcattgta tcagagaagt ttgggggttt gggggaaagc aggcattctt cgttgaatta 420aacaacaatg gagctataaa ttagcacatc cttttaatag gaataacacc cacactacag 480ttttataaat ctcttctttc caaccagtga gagtagccta tactctctga ggtaagaagt 540cattgagttt ctttccaggt tttgtaaaat cgcaaagtag gaaatattta ttaaatatc 599229599DNAHomo sapiens 229gcaagatgaa aagtttaaca aacaggaact gtggccctct ataaaggaaa gcatccaatc 60tacagtgagc caacagctgg agagtgggtg aattaaaatc cgaacttcac tgtcttacta 120ctttctgatc tcttgccaat atctcacatt aggtgaactc aaccagaagc tggaggtcag 180cggagcctgt ggatgcagtc cttatgggtc tgcttccaag gcataaagcc acatagggaa 240ggacagagat tagacctaaa ggggaaatta gaagatatcc ggcatagtaa atatccttgm 300aaagtatcca gaactgaaac tatcctttag ctctgacttc ttccaaaact ttttttgaag 360cattctaaga aagctcaact cctatattct tcttgaacaa ccttctccct attcatgtcc 420tgttatgttg tagaaaaaca gtaaagtaag caagaacttg ttttaccccc accggctggg 480agtaagactg tttcttcaca gagcaatgaa cgtaagcatg aggtttacat gaatatattt 540agtctcctca ctctccaatt caaaaagatc tgggaacatt tcacagccat gggctgatt 599230599DNAHomo sapiens 230ttcttcacag agcaatgaac gtaagcatga ggtttacatg aatatattta gtctcctcac 60tctccaattc aaaaagatct gggaacattt cacagccatg ggctgattat gcaggtatca 120tcagcctggg aatataatga aataaaaaag ttgtttttca catttgtcat aggaaactcc 180ttcacctact ttctggtcca caaatgttcc caagagatct tagaggaact atggagtctg 240gtgaaccaca tcaatgattc agaccaacag caaatctgca tgagcataaa cataaaatgs 300aaaggaaaca ggcaaaataa atatcacttt cagaggtgaa cactagccac ttctccttac 360ataaatacca tgcttggcta taaacaaggt agaatatgaa aaaaagaaac aatgtccacc 420tctgaaagtg tgacactctc ttttatatga gcatatgaaa accaagaagt agaatgattt 480tatgacttgt gtcctggagg gtccagagca atacacttta ctttcaagac caaagaacac 540ccttctgcta gggaaactcc attattacac cctttctaaa ttattaccaa gcttaagct 599231599DNAHomo sapiens 231aaggagggaa agaataagag aataaaagaa ggagtgggaa acaataacga aatgaaagaa 60acagtgagaa gcattattaa aacaagaaat aaaagtatta agaaaattaa tgaatgattt 120atctttttag tgagggtagg agaaaagagc tatgtcatgg atcattttct ggtccttcac 180atgggtaaga gtattgccta agcttcctga gtaatcacag agtgttacaa atgatgtcac 240ttctatttcc atatggaaga cacaccattc ttgacctaac ctaggatttc ccaaactacr 300tatgcagata ctgttcactc cttcagcatt tggacaaatg aaaagagaag gaaaacagga 360agcttttcag ctcaccctga attttcacag atggccctgg tctgaattgt tgccccaggt 420gagacataag cagattccag gaagacagca gcaaagagct agaaaaagaa gtatttatag 480agaggttctt tcaatggaaa agaatttgct tcctgacaat gatcttcata gaaggttaat 540atgcttaagc acattgagaa ttcattgaat atctattaca tgtagtacag aagacagcc 599232599DNAHomo sapiens 232tttgtcaagg attcttacaa gtgatattca aatatctaat ctaaaatgat tatctagaaa 60ttggcacatt ctaagtgtgc agatgctgat gaggagcagg tattgataga cagcgcgtta 120tgcgtcaaag gatgtctatc ctttgctaaa gtgttactct gactatgctg taaaaagcag 180gaggtaagag cttaagaaag aggagtaaaa gagataattc tcatgagata aactctaagg 240attgatgctg tgctccaggt ctctccagtg ttttagatgt ttcaggatgc tatttattam 300agaatatggt gtacttggaa ttttttttaa catacagtag taatcatttt cctgattaac 360ctaatttcta gacagagttt gcattcatga atggccacag tacagatgcg gacatccaaa 420ggatggcatt attactcaca agcatagtgc tatgtgcagt tatggcttga gggaagggag 480gggggaggtc gccctctgag acctgaacct tttggtgtgg tttcaagcac taaccagcac 540tatctaatgg ctatttcact gccttgtcaa tgacatagga aaaaggtacc tgagtggaa 599233599DNAHomo sapiens 233tgtcaatgac ataggaaaaa ggtacctgag tggaaactgt tttcagggca cctttaaagc 60ctgggagcaa agggtggagg gatgattttc cttgtggact taaaagtctt taccctcttt 120gtcctatttt tctttcttcc agaccaaaag taccgagttc aacaacaccg tctcttgtag 180caatcgggtg agtagagagt tcagtgctgc tggctttctc cagggagacg ccaggcattt 240tggagaggga gtatcctgct acgtgcagaa ctccgagagg tgcctgggct ccgggacgcs 300gccgccgggg gaaaggggac atctgggctg tcagagcggg gctgcgccta gcttgggaca 360acacttctgt tccaatttag ggagaggaag tctctatccg gaggaaaggc aaattgggaa 420ctgggacgag ggaacgttgt taggggcacc acctgctggg gtccggcgcc tccgcgctcg 480ggctcggaat tttggcagcc tccgccccct ggagacttgg gaggagcgag cgtgggtgac 540agtcttttcg cgacgagtgc cctccgccac cctcgccacg cccctgctcc cccgcggtt 599234599DNAHomo sapiens 234attctaagcc aagttttaaa tattatctaa cagacaagag tggtatatac aagtagatcc 60tgagaagtac ctttgttaca gctactataa atatacatat aaattataga atctacttta 120atttattttg tgaacacttt tgaaaatgta catgttcctt tgtaattgac actatatatt 180tcttaataaa ataattctca aatttgtttc ttatgaatca tctctcaaat ctagttagac 240aatttgcaca catacttttc taagggacat tatcttcctt caggttttta cctccactcr 300tccttagagc ccactgactg ctccccttta tacctgttgg ccctgcctat aggagagaat 360atttggagat aggcagcttc aggatgcatt gcaatcatcc ttttcttaaa ttatgtcact 420agtcttttat tttttcccct cttgaacttt cctcacacct ggaagaaaca aagtaggaaa 480aagtgaacag gggatgtcaa atcgattctt gaattcccgc tgcaagctag agccgcaggc 540accctctcac tcaatttcca ctcagaaccc tataaacacc agtgggaagg gcaacccac 599235599DNAHomo sapiens 235cccactgact gctccccttt atacctgttg gccctgccta taggagagaa tatttggaga 60taggcagctt caggatgcat tgcaatcatc cttttcttaa attatgtcac tagtctttta 120ttttttcccc tcttgaactt tcctcacacc tggaagaaac aaagtaggaa aaagtgaaca 180ggggatgtca aatcgattct tgaattcccg ctgcaagcta gagccgcagg caccctctca 240ctcaatttcc actcagaacc ctataaacac cagtgggaag ggcaacccac tgcacgtggr 300aatgcactga tttttcctag gagtagacat gttcctctaa ttactccctg agggttagtt 360ggggctaaac catgacagaa gtggggaagt tcaatgtcct taaatccatc ttacttgcca 420acaggtaaga ggaagcttac attacatgtc cagtccacat ttaaagagca cttactgtgg 480aacaagcctt cagccaaaca atggggatag aaaagtaggt aagactcagc ctttgtccag 540agaagctcag ggtatagctg aataggcagt ttcttttgtc ctgaggaaaa tcaggacat 599236599DNAHomo sapiens 236cattagaaat cttaaaagta agacttgaaa gaatcaaact gtttccaagt aacttagctg 60aatcctacaa taaacttcaa gaatatctgt agaaataaaa aatacctagg acccaaaaag 120gaaaattcac aatattttgt atacaactaa agattatcag acatgaaaaa agtgagaaaa 180tataacacat gataaggggg aaaagtgaaa ctgattcaga gctaacatcg aagttagaat 240tagcagacaa ggacattaaa atggttattg taaaatggtt attgtaacta tattcaatay 300gttcaaaaag ttaaatatag acacagaata cataaagaaa atcccagtcc aacttctaga 360tatgaaatct gtaatgtgtg aaatgaaatg cacagtgaat ggtaatcatg agagattaga 420tgttgcaaaa aataagatga gtaaacttga agacatacca agggaaacta tccaaaataa 480aacacagaag gaaaacaata acttaaaaat gaaaagacca tcagagagct gtgaaacaac 540tgcaagtgcc taatatacat gtaataagtc tctttaagta aagaggtacg gaaaaaaat 599237599DNAHomo sapiens 237actagtatag ttacgttagt cactcgaccc aaaccttaat aggctgccaa aacgttttca 60taaacgaaat gaaatggaaa taaaacagta agagaagagg ttattccata tgttgaactt 120tggtcctggg ctctaagctc accactgttt tagttaatgt tcacatgctc agagattgtt 180ccccaaacct acatcttggt aaggcagctg gctcctgagg agtgaggcgt cttgacaccc 240acttcactgg aatcagtctc cttcagcatc ctaaggcact cagctctaat gaactgcccr 300gactcccgtt tgcattatga taagctcctc tttagaacct ctactgtctg cttttgacag 360ccgacctcaa ggaatactga cttaatccag gaatcccaat aacatttaat atttatcttc 420cttttctggg aggaatctac acttatccaa gttgcccaag tgagcagttc cctccccaca 480agtaattagt tctactcccc agagggtctg tgagtgaatc cctctgtcag ttttgaaatg 540tcccattata gttttcatct gtaaatatgt caatatgtat ccaaaagatg aggatcttt 599238599DNAHomo sapiens 238ttaatatttc gccatccggt cacgtccacg tgctgatttg gcacttgcag tcctcctggg 60gcgtgtttca gaggcagcct ggccaagggg aaactgctag agaacatctc agttgtatgg 120cagtaatatt tgttcagtga atatttattg accttccctt gaaggtggaa acataattaa 180gacaaacctc tacctcttgc attcttaatg agagagaaaa acatgcacgc tattacgtta 240ttggtgacac gagctgagtt agaaattcac tctaggtaga atacattggg agaaccggar 300atggtgagat taattaccgt tagggaaaat atctaatagc aatcagttat tttcaactaa 360cgcaaagtgt ctggcactgt cactctaagc cttgcagccg tttctttgca acataggtgt 420cattataccg tagcaccttt atataatcta ttaaagtaaa tttcagataa atcacttgtt 480agtgatgatt ttttctccta taacagttca tcgatcattg taatagtgtc tcttgtttac 540ttgtttcttt tgtcttctcc gaaagaatgt aacctctgtg agaacagaaa ccttgatga 599239599DNAHomo sapiens 239agactgtaca ctgctcagat taaccaatgc attgggctgt gacctctaaa actgaaaata 60cttgggagta aaaagaaaaa aaaaaggagc taatgaacct aagtcactaa ttgggtctac 120aagtgctcta tcccatgact atggctatat atgctgtccc cagtcagact tcctacagtc 180ctacagatta gtttcttcta caggggaaac tagacaagtt gtgaataggt ggtggtagtg 240atggtagtag ctatcatgta ttgagcagtt actatatgac tggccccatt ctgttttacr 300caaatttact cattgaatcc tcataacaat cccataaagt aaataaatac ctgttttaca 360gatgaagaat ttgaggcaca gggagcttat ttttccaggg tcatacagct ggatcagtag 420ccatgattgg ggtcagcaaa ttacagtctg taagccagtc tagcccactg tttgtttttg 480tatgacccag gagttacgaa tgattttgac atgtttaaat gtttgtgggg gcaggctggg 540ggtagggaga aggatatttc atgacatgaa aactatgtga aaatcaaatt tcagtatct 599240599DNAHomo sapiens 240ctggtagatt tagaccagaa aagatctttc cttagcagtg gagaaaacat agaatctagc 60tttctctaaa cagcgaacag gcatctgatt tttagaaaaa gagttataag ctaagttata 120cataataaat aaccaatcca cataaagtgg tggtgcaaat atgaattttc taggaaagta 180ttttaaaact acacttaata atacacatta tgtcctatct caacaaatat acaaaataga 240aaactcctga gatgggaact aacggcataa aaaattttga agaaggtctc caagtaatty 300tgatattcat ctctggcaaa gaaactgaag taaagcacca gttttaagta agccttttct 360gaaaatttat cttcctccag aaaactgaat atacattaga aaaaaaagaa tactgtatag 420ttccagagtg tgctgggtaa agaatgacaa aattaaagtt ccctccacta tcatgacaaa 480caaatactga ctgacaaaca agtagtttag cgataccaac ctctttatta cgggcaaatg 540cagagaaaac atttccataa gcagcaaaga ctaatctgcc atcagctgcc atacagcag 599241599DNAHomo sapiens 241atatcaaaat tacttggaga ccttcttcaa aattttttat gccgttagtt cccatctcag 60gagttttcta ttttgtatat ttgttgagat aggacataat gtgtattatt aagtgtagtt 120ttaaaatact ttcctagaaa attcatattt gcaccaccac tttatgtgga ttggttattt 180attatgtata acttagctta taactctttt tctaaaaatc agatgcctgt tcgctgttta 240gagaaagcta gattctatgt tttctccact gctaaggaaa gatcttttct ggtctaaatm 300taccagttgg tttctgaatt tgtcctggaa caactagctt gagaagtgac ctggccttaa 360tggtctagaa

tgaaaggaaa tgtaggaatg ggggtacaaa gatagccaaa tgatagtatc 420actgtacttg tcagggactt ggagtgaggt ggttcccaca gtctttcatc atcacttcct 480gtggcagagg aaggtaactt atctgtagag ttctttaatg gaaggtgttc agatttttag 540aattggaaaa aatgttcatt tttgtattgt tgtttatagt tttcccaggg agatatatg 599242599DNAHomo sapiens 242tctctgtcaa agcagaaggg tatggggaag aagaccctat atcccccttt cccatctcat 60ctgaaagcca gttggtgatg gagtctttag agatcagcct tctggaatat accatctcgc 120taggatatat gtagttgcac tgattgaatt gggtgaggga actaggtgtg tgtgcatgcc 180tcctctctaa cccaagatgg aaggcagagc ctcagaggtc tcatttcttt gttcttaatg 240gacagtttac ttccttattg ttgaactggc tgagggagca gatgaacatg cctggtccck 300taatatttat gtgttcatcc taaccttgaa taatcaaaag ttggggtaca tttcttaaca 360gaagcatctc aggattagca tgtttttggg ataatatgaa taatatgaca tgatgactga 420gtaataatat gaaattcttt taaacttcga tgttttagat agtacatacc tttaagggtc 480ataaggcaga aatccatttc ttgcaaccct ttggagacca cattatctct gttgatactg 540atggcattct tattatttgg cacatatatt cagaaggtaa gagttaactc atttatttg 599243599DNAHomo sapiens 243aaaataatct ctaataaagg agaaaaaaaa aacgtataac cctgtggagt ggggggtggc 60atcaccagtg gtcacttgct ccaagataaa aaaattctct gaaatctttg gttacattca 120aaatttctat gtttgaattc tgcttttcac tttacagttc ctccatgatt aaaacaatgt 180tccactctat tttccagtaa atttgtgtat caaagaaggt acatttcact taatctttag 240gttcacatac tatctggcac actactgtac aatcccaggg tatgggtacc acagtttagr 300atgtacaggt ataggtgaaa attatataaa ctttactttg aatgctattt taagagatcc 360ttgcctttat tcgtcagtca ctacaaatgg ctccctgaat atactggttc aagagagtct 420gctggaatgt aagaaccaga tcctgtaacc taataaaagc ccttttaact tctatctgca 480cagggaatac ttttggaatt ctgttccctc cctctacttg agcaaaaaca aaacaagaaa 540agggttacta atctgaaaca agaacctgga ataattccca gaaatgcaat cttcaggat 599244599DNAHomo sapiens 244attagtatct aagtctgtgg tttattttaa catataaatc tttgatgtga tagacttact 60ttaagtgata aatatatggt tacataaaac attttaaact attttataaa aaatatttat 120aactttcact tttgtagaag aatacctgca gttgactttt gataaatcag tatttaaaat 180ttctgcaatt ttgcatccaa gtacctactt gaataaaata cttctgggca gtgaacaagg 240aagcctgcag ttgtggaatg taaaatccaa gtaagtattt tagttagaaa ataatatagy 300tgtcacctta tcctcatcta ctacttccta atgtatactt aagtctcatt tctccctgcc 360cttgtatatt tatttggagg gttgtctata aataacagtt ggtcccctgt atcagaggag 420tcaattaacc tgggatcaaa aatattcaag gaaaaataaa taaataataa tacaacaata 480aaacatcaca ttttaaagta gtacagtata acagctattt acatagtatt tacattatat 540taggtcttat aagtaagcta gagattattt aaagtatatg cataaatgtg tgaaagtta 599245599DNAHomo sapiens 245catttccagg atggaaagtt ggagtgacag ctcttcagca ggttagtatt tttctgttaa 60gtcaaagagg aacaaagtta ataggaaaat ccttcagttt caggaatcaa tcataatttt 120agacgtaaag acgaaacaat atatagctta gtttaccttt aaaattgtta gcctgaggaa 180atagtgtttt ggaaatgtaa gttaaaacaa gtaataatgc ctttgccaat aacacttatt 240ggagtccttt gtgcttatag tttgacttaa atctgtggtt gctatggatc cttgtttctr 300atcattttgc aagtatatgt agtccattgt cttgtgtaga ctggaaatga gtgttcagca 360atgcaagcgg tattgtaagt catgtagaga aatttgtcaa gatgttgaga tttatggttt 420gaagtaattg gagccaaaat cctaatgttt gattcgatga tggactattt aagaaataac 480tgcttttttt taatgaatct gcaaaatatg tataaataaa tgaatgcatg tctacagcga 540atcttgtgtt tatattggcc acatatgtag ccactatacc cttatctttt tcagtatcc 599246599DNAHomo sapiens 246taaccataga atattagaac tggaacagac taattgtaaa actttttttg ccttttcaca 60tgttttgtag gtttttccta ctttcttgga taagcaattc ttcacttcct ttgtaattgg 120ttacatgttg ccacacatag cgcaagcctt tatgttttct agttgtctcc tttttctgtt 180tccatccagt ccagtgatct gtagtgattt tatacatagc tttctttttc tgttgtggtt 240gttttctttc caaaatctta ccagctaggt tttgggaatg aggatgggat gttgactggs 300agaattgaag ctgggaagta atttggaaaa atcattactg aatacttcta tgctgaataa 360aaaagtatgc ttgaatggta atacttgctg agtttttctg ccatctttta gaagatactt 420cattatttct tttgataaca cctaataatg atgcgtatca tcaggattat taaagctatt 480ttgcttaaga aagtaaaagt ttgaataatt taatttttag gcaccagccg tggatgttgt 540tgctattggt cttatgtcag gtcaagttat cattcacaac attaaattta atgaaacat 599247599DNAHomo sapiens 247tcaatgcatt ttattttttc ttggatgaac tagataaaca tgtatggaag aggtagtaag 60attcctagca tcaaagttgc tatagaagtg attgaggttc tgctataagg ttattgaaaa 120aagttagaca tcttgggtgg taaaaacata ctgctgccac ccaaaagatg ttcatggcct 180cacttgagct atctgtagag tgcacagttt ttaaaatgga aggtagctta gagaaagcat 240caaagtaagt ggcatccaat atttttgctt taaagcaatc atttattctc tttcccttty 300catggtttcc agcctttgaa agattttgtt tattaaacaa caaaatctta cttggtttta 360tgattactaa tttttaagtt actatcttat actgttcatg catgtatata aattttaaga 420ttatttttaa caatatctaa aataactttt cttagaatta aaaaataaca gtggtaataa 480catctttgtt ttgtttctga cttaaatggg aatatcttgt actttatagt tacaagactg 540atagcttttc ttttatatac actttttatt aagaaggatt catagctatg tatgttccc 599248599DNAHomo sapiens 248aggttctgct ataaggttat tgaaaaaagt tagacatctt gggtggtaaa aacatactgc 60tgccacccaa aagatgttca tggcctcact tgagctatct gtagagtgca cagtttttaa 120aatggaaggt agcttagaga aagcatcaaa gtaagtggca tccaatattt ttgctttaaa 180gcaatcattt attctctttc ccttttcatg gtttccagcc tttgaaagat tttgtttatt 240aaacaacaaa atcttacttg gttttatgat tactaatttt taagttacta tcttatactr 300ttcatgcatg tatataaatt ttaagattat ttttaacaat atctaaaata acttttctta 360gaattaaaaa ataacagtgg taataacatc tttgttttgt ttctgactta aatgggaata 420tcttgtactt tatagttaca agactgatag cttttctttt atatacactt tttattaaga 480aggattcata gctatgtatg ttcccctttc ccccatcctt aggattaata aataaaaaga 540gagttaaacg taaaggactt cagaatacca tgtcagtgag acttccaccc atcacaaag 599249599DNAHomo sapiens 249agcaggtaag taacttcaaa ctgtgttttg agaagttctc ctttgtcatt tatttcctac 60tgtatgctgt tttattttct gttttaataa atgcttttac aaatattaat aagcattcag 120aaggtaaccc caggtgcatg ctggtcttgt gtgaagacta aaaatgagtt attttaaatg 180tgaacttctt atctattaac atcaggcttt gctcttctgt ataacaggta ttaataatat 240ttgattttat agccttttta ttctgtcata tgcctggtat aatgaaagtc actaatgtar 300aaagaactgg aacagcagag tatgagaaca tagagctctg actaattaag atctaagaat 360actgaggtct tagtatacta tgtcatttga cctgtgccac tttcaaagaa gtgattttaa 420gaaaaatata gataatgggt ttgttgcgtg aaatctatca tgggaaatta ctgtagaggc 480accatttcta tttgaaagtt gttattatga ccacctttct gttttctcag agcttgagtc 540atgtttctaa aaacatttga atcacatcac acatctgctt aaaatttttt agtggcttc 599250599DNAHomo sapiens 250ttacgtttta gaggaagctc gtgaaagtga ctgggatggt atcattgctt gccatcaagg 60taagctatct tgctcaacct ggaattatca gaaatctaca ataggcgctt actttctcaa 120gccaaaagag ttgaagaaag atgacataac tgcaacagta agtgagcttg tttataagag 180tatcttctct ttaaaacttt cctatggaaa tcttgttata ctcaaggttt ctcatcataa 240tattgactga aaaaacgtag tttaacattt taaagcattg cataacccaa agccacaaar 300atttgctcct gtgacttcta agagttttct agttttagct cttatattta gatttattct 360ctctgaattg acttttgtgt atggtatgat aaaggggtcc aaattcattt ttttacatgt 420ggatatccag ttgtcccagc actatttgtt caaaagacta ttctttctcc attgaaagat 480cttgtttcct ctgctgaaag tcatttgacc atgtatgtaa gagtttattt ctggactctg 540aattctcttc cattgatctg tatgtctgtt cttataccag taccacactg tcttgattt 599251599DNAHomo sapiens 251tctgacagtc tcagctatct ggagcaaagc tagtaaccaa taagtaataa gcaaaaatac 60gtatagagag cctgtgcact aaagtacaat ttgttactca aagataacat tcacggttta 120tttatttttg ctttgtttgg cttagataat acattagaat gaataaatta gaagaagaga 180atgccaggag caggccgact aaaaacaata actcccctaa aaaaatgtaa agcaggacaa 240tgtagggcct gtattacttg caggttatag catacaagct cctttagttt cttgattgtr 300taactataca acatagcata aacatttatg aatttttcaa aataggtcag cttaatgttt 360gtgtttcatt taggaagata aaatgctttt taaccatagt aatttcccat ctaaaatact 420ttttttaaaa gaaatcttta tctagaaaaa tgtatgtatg taaaacatat ttatgtgatg 480caatgtaaat atgtcgtgac aaagtggtat gtcaaacttt atgttgcttt gcttagttaa 540ataaaccttc attaaatact ttctacttag tttgtataag tcatctgttt agatgtaaa 599252599DNAHomo sapiens 252taatagaaaa atgaaatctc tcttaggttt tctcatcctg caaaattgag atacagaagc 60gagatgccta aaccttaaga aagctcattt gacctttttg atactccaaa ataaagctca 120gacttaagga tggcaaactt ttgagttttt ttagttcatg ctgaatttag ttaaaaggtc 180aaacccccta acttttcctt tttgtatgtc tcttctgctt ctctgacata attcttaaaa 240gaaggcattt tagatagtct tagtgcattt tctgttgctt ataacagaat attgaaacty 300ggttatttct aaagaaaagg agtttatttc ttacactttg ggggattgag aagccccagg 360tcaaagggcc atatctggtg agagccttct tgctggtgga gactctgaag agtcccaagg 420tggtatggag aatcacagag taaggggact gagcgtgata atgtaatagc ttgagtctgt 480ctttctcttc ttataaagcc accagtttcc ctttcatgat aatcccttaa tccatgaatg 540ggttaatcca ttaatgagga cagagtcctc atgatccaat cacctcttaa aggcactcc 599253599DNAHomo sapiens 253tgaaatctct cttaggtttt ctcatcctgc aaaattgaga tacagaagcg agatgcctaa 60accttaagaa agctcatttg acctttttga tactccaaaa taaagctcag acttaaggat 120ggcaaacttt tgagtttttt tagttcatgc tgaatttagt taaaaggtca aaccccctaa 180cttttccttt ttgtatgtct cttctgcttc tctgacataa ttcttaaaag aaggcatttt 240agatagtctt agtgcatttt ctgttgctta taacagaata ttgaaacttg gttatttctr 300aagaaaagga gtttatttct tacactttgg gggattgaga agccccaggt caaagggcca 360tatctggtga gagccttctt gctggtggag actctgaaga gtcccaaggt ggtatggaga 420atcacagagt aaggggactg agcgtgataa tgtaatagct tgagtctgtc tttctcttct 480tataaagcca ccagtttccc tttcatgata atcccttaat ccatgaatgg gttaatccat 540taatgaggac agagtcctca tgatccaatc acctcttaaa ggcactccct ctcaatacc 599254599DNAHomo sapiens 254ggtttgtctc tttcacttaa aatagagtga agcaaaatcg aatttattga ctgtatcctc 60ctcaggcttc agaaagttca cttaaagttg gtatttcttc aattaaaaaa acattttgtt 120aaagacacta ttagaaatat tagtggtctg tcacttcttg ggctgttgct attttctaaa 180agttaatgtt atataatttg aattgcttta aaataagaaa gttgtataaa tagtagagtt 240ggcatagtgc ctttttcatt ttcctgttta atagttttag tttatattag tgagagagak 300agattattca gtagtagtaa attggcaatg tattataagt ggtaaattcg tctttggaat 360gaaaaaatta ggatctgaaa gtagcattca aagccactaa cctttgactc agcattagcc 420ttttgctgaa tttcttatat cagtaagaag ttgaacagat tcaaatctga tagattttca 480gctctagtat ctttattttt aggtgaacag gcaattttaa gtgaatagag aggcatgaag 540ctgggtgtag cacaagagca agaagtgacc acatcgaatt gttaaaagaa aatgtaata 599255599DNAHomo sapiens 255agtttgctca agcagtaagc tttttaacag atagtaccta aacatgttag gaagttttac 60ccttcacgta tgtaaacttt tgatgagtaa tattaagaca aaggaaatac cttaagattt 120gaaattgccg tgttttaggt ttaatcttta tatgtgttag gataatatct tcatctctgg 180attgtttgga ttaaatgact taacataaat aatttaatag tgtatggcat agaataagta 240tttagcaaat gttttctttt ccccaattct cttgattccc aataaaagcc attcttgtgr 300gctttcaaaa cagacttgaa cagaaatcag acaggttatt gctcccttcc ccataatgga 360caattaaaca gcagtccttt tcctgaacac actttgatgt gtgtgtgttt gtttccagtg 420cttctaattg ttgtcttttc tttccatctt gcattcattg tttaaggttt acatttttat 480tggctctttt agcaaattga gagaggcgtt ttaccatggg caagcaactt aatgcctccc 540actggacagt cttcatttac atttgagctg ctcacagtgt gtgtcccatg aatcactga 599256599DNAHomo sapiens 256atgaagtact gctattaata acttgaaacc tgagattctc aatttttatt ttctattcca 60gattcataag gtgtgggaaa aagaacctgt cccctaaaag accggtatct acatcttgat 120tagtcatcca tggctagggt gcaggctgag tagcagaaat atggctactt agagggccat 180tctagagaag gggaatctat gacctttcag cagccacaag aatatgctca gcatattcgc 240actctgactt actctctgag ttcatctttc cttttaattt ccttaaataa aggttgatay 300atgtcaaaac aatatatgaa atttacttta ccttataaaa ttattatcta ctactggtct 360gtctttaata tgtttttgta ctacatcagg aaagagactc aataatgtat ttacacagct 420ttgttatgat ggcatctatg acataagtca aggcgttttt aaattgataa caatctatct 480ttgaggtatt ttttaactaa taaaagtctg tagtcaaatt caagattgta gagtgtttct 540ctgaaagaaa ctttttataa tttttaaaat attgcttatg ttttgatttt tcaggtcca 599257599DNAHomo sapiens 257ttaatatgtt tttgtactac atcaggaaag agactcaata atgtatttac acagctttgt 60tatgatggca tctatgacat aagtcaaggc gtttttaaat tgataacaat ctatctttga 120ggtatttttt aactaataaa agtctgtagt caaattcaag attgtagagt gtttctctga 180aagaaacttt ttataatttt taaaatattg cttatgtttt gatttttcag gtccaatatt 240tccctgtatt cagttgtttc attacggcca cttcctgcag attatgtccc ttcaatagts 300atgcttcctg gtacttgtca aacccaaggt aattagaaaa ttgcaaagta atttttgagg 360tgtaatatta taaacctaat gtaggagata ttgctaccaa aggcaaagtt tagtgcattc 420aatcaaagtg ttttttaact gatataaaag actttgaatg acttcatgaa tttatgcaaa 480aatataattg atgtggtatt gataagctat caaatagtat accattgaag aaggtgtttt 540gggtctagtg atgggagttt tagttaatat gagaaaataa ggaaaagaca gggataagt 599258599DNAHomo sapiens 258agtatatcgg tgtatgtttg tatgtgtttt ctgcacttct ttaccaagac ctagttttac 60agatataggg taaattaatg atagctttta attacaaact atacattttt gggtgatact 120tgaattattt gaataatgtg tatttgtttt tgtttaagtc taaagtggta aatcttggag 180ttttggctca aaaatcagat ttctgcttga aacttgaaga aggactggta aataataagt 240gtaagttgaa ttataagata ttttaactaa tatatttagc ttattttact gtatatgags 300agaaattgaa ggaaatatca gcgttctcag tagttaagat agtaaaaatc aaaaagattg 360aaattttggt tttaatttga cgtaatttta gcatttatat taaataagcc cactaaactc 420aaatggtatt gatattataa aaatctgttg aagatttttc atatatctaa cttacttttt 480gctattggag atggacacag ttattgacta tatttataat aaggagatcc ttcttgttgt 540gaattaaatg taaaagtttt gtttgtcgtt tttgtagcaa gtaatttgca agtcttttg 599259599DNAHomo sapiens 259tgacttgtta tgtttatggg gagacaaaga aataaaaaca ctattgttta ctatatactg 60aaggatctaa aagtgattag acttttgtca ttggtgatac tctttttcag aaagctaaag 120catagtcatt gcagttctca aatgactcat aaaaatagct gtaagtgtac tgagtgtgtt 180ttcctagggt gcatatgaaa caattcttct agggaaaaga agtaggtttg ggctgggtaa 240gaataaggga tggggtcttc cccctctgat tttatatatt ctgtactgtt agtaatatak 300ttcctaatga ttatgtactt ttataacttt ataacaatag aaaagaaaaa ttattttacc 360tcatcagatt cccaatgcta accactatta atacttttgt atgtatcgtt ataggcttct 420taattaggat ttactctgag agaagatata tgagcatttt aaaattctaa cgtgcctgtt 480gcaaggcatt agattttctt tattaacagg aaaaaggttt aaattacaga aaaaaaatgt 540gttttgagta ctttctctta tattggtgtc atcgtttgta ctgattttca attattttg 599260599DNAHomo sapiens 260cttctgaaag aatcaggccc atcaggaatt gaaacagagc tgcgaagctt gtctcctgat 60tgtggtgggt ccatagaagt tatgcagagc ttcttgaaaa tgattgggat gatgctggac 120agaaagcgtg attttgagtt agcccaggca taccttgcat tgtttctaaa ggtaagtcta 180atgtaagaca gtactgccca gcttgtcttc ttctggggca gtgctatcta acagaacttt 240ctgcaaagat gggtatgctg tatatccatc ctttccagta tcatagccac ttgccacatr 300tagctattga gttcttgaaa tgtaaatagt gtgatcaaga aactggattt ttaattttat 360agaattttaa ttaatttaaa tttaaataac cgcatgtggc tagtgactac cacattggac 420agctagacag tgcagcttgg gagtcttgtt ttgttttttt actcaactgc acaataattt 480tgactttacc ccctgacatt tttatgctat ctgcttgatc caatgtgctg aaccattaac 540ttttcttttt ttagtggtta gttacatttt ggaagttttt tgtgattatg aatagaaag 599261599DNAHomo sapiens 261ttcttttaga aatgtgtatt gacttattaa agccactgac agaaatgtta atcatgactt 60aagttctaat ttaaaaaact attttcctct ttcctaaata ctatattcta aattggaata 120tggcaaaatc ccaatatata attctatacc tagtaaagat tgtaaataac taaaacaaaa 180tgataagagc tgtgaactga aattgtattg cttacagaaa tcatgaaccg aattttcttc 240tctttttaaa gtgagcataa agacttaagt gtattgttac cagagatata tttagatagw 300atacatcatt ttggcaggta atcttctaga acctttcatg tactgtttcc atcaagggag 360ggaaagaaat agaaaatata attttatcta tattttcctt aaaatatatc aatctgtgca 420cactctttca gttttttaat tactcatgta atatatgact acattttgct tgtgtgcttt 480ttgaaaacca tcttcagtcc caatatcctc tgtagaagta atagttttaa ctctcctaga 540tcttctttta gagtgttttt atgagtgttt aatgtaggaa tgtgtatata ttatctaca 599262599DNAHomo sapiens 262aaaacccacg agtatttcac cctctataaa aaaatgttaa atgtaccctt cccaaaaaga 60aatacctata accaattcct gtaactattt tccaaccttg tatgaataat gttgtaatcc 120tgctaaagga aactcctctg tctctgccta cataaatgaa accttaactt ctctacttta 180gaatactgac tctgtatctt tggagttgat gtttccgggt gggctatcct caaattttgc 240acttgtataa gctctttaaa ttagattcat acccttttga ttattttagg ttgacgtaar 300gagcttgtta aacaaaaaat tggggaaggc catggttttg cactgaactt ctgcactggg 360tcccagcaga ccagaacaaa ctaatggagc tgctcatact aaatgccaca taatcaaact 420gaaacttcaa ggaagcagat aaattccaaa gcagaccatt gtttcctttg aaaacagatt 480tcagtctacc tgagtcagca caataaggaa gtcccctcta ctttaatcct tacaaaaaag 540taacccgatg ttaacctttt ttctctattt ttctgtttcc caccttaaaa aaccccttg 599263599DNAHomo sapiens 263ataaatgaaa ccttaacttc tctactttag aatactgact ctgtatcttt ggagttgatg 60tttccgggtg ggctatcctc aaattttgca cttgtataag ctctttaaat tagattcata 120cccttttgat tattttaggt tgacgtaaag agcttgttaa acaaaaaatt ggggaaggcc 180atggttttgc actgaacttc tgcactgggt cccagcagac cagaacaaac taatggagct 240gctcatacta aatgccacat aatcaaactg aaacttcaag gaagcagata aattccaaar 300cagaccattg tttcctttga aaacagattt cagtctacct gagtcagcac aataaggaag 360tcccctctac tttaatcctt acaaaaaagt aacccgatgt taaccttttt tctctatttt 420tctgtttccc accttaaaaa accccttgtt ctgctattgt ccagtgggat ttctcattct 480actttataga atgaagggct tccctgatga atggtggata aaaggcaatt aaatttataa 540ctaaatatgt tgtaattttg tcttctgaca agctaaatta gcattatata gtccaatca 599264599DNAHomo sapiens 264aatcttccct ttagcataac agagttataa gaaacatgaa gacaggaagg tgggggtgtg 60tgggggtggg gcgaagcttt tttgtccctg gaggatggtg aaaagattac aaaaagaaaa 120cagaaggatt cctcttcctt cagaggaaga aagggaagtg tcataagtga gggggaagac 180ttaggaccca gaagggaggg tttttagtct ccagtgtgca atcttggact ttaggaagag 240gctgcacatc aagtggattg ttgactgcct ttggcaggca ctagttgcag aagaaatacr 300caatcaaagg aatgcagcac tctgcaaaga aaagcagaat tcaaagagta tttcttgaat 360ttctcagtgt cacagatcac aaaaaaattc cggaaaacaa agatattatt agataatcca 420gtattcctga attcttaaat ttccattcct gtttaaacat aacatttctg taatttgcag 480tcaagagtcc taaataatgt tagaaagtat aatttaaaaa atattaacat tggccttgca 540ggcagagaca ttagtaaaat cttgtttcag tgacctggct ctctctgggc actttgatt 599265599DNAHomo sapiens 265ttatactttc taacattatt taggactctt gactgcaaat tacagaaatg ttatgtttaa 60acaggaatgg aaatttaaga attcaggaat actggattat ctaataatat ctttgttttc 120cggaattttt ttgtgatctg tgacactgag aaattcaaga aatactcttt gaattctgct 180tttctttgca gagtgctgca ttcctttgat tgtgtatttc ttctgcaact agtgcctgcc 240aaaggcagtc aacaatccac ttgatgtgca gcctcttcct aaagtccaag attgcacacw 300ggagactaaa

aaccctccct tctgggtcct aagtcttccc cctcacttat gacacttccc 360tttcttcctc tgaaggaaga ggaatccttc tgttttcttt ttgtaatctt ttcaccatcc 420tccagggaca aaaaagcttc gccccacccc cacacacccc caccttcctg tcttcatgtt 480tcttataact ctgttatgct aaagggaaga ttacattttc agaggatgga aagctatcat 540ctcactgaaa aatcccattt ttgaatggta gattatgagt attcgcatag tatttcacc 599266599DNAHomo sapiens 266aaaaaagctt cgccccaccc ccacacaccc ccaccttcct gtcttcatgt ttcttataac 60tctgttatgc taaagggaag attacatttt cagaggatgg aaagctatca tctcactgaa 120aaatcccatt tttgaatggt agattatgag tattcgcata gtatttcacc ttacagccct 180gcaaaacaaa atggtagtcc ccttctaata tgacagttgc gtcaaatctc agaaaaggtg 240atacgtttgg aaaggcaaag gaagaagacc acatcaccct ttaaagaatt attcttacay 300atttttggtc attattagcc ttatttaagc tctgcagact ctcttgtttt ctgctgttaa 360tagtttgaga tcctgaaagt ctcaagccaa aattgtttcc aagagtaatc tcactgattc 420agatataaat ttaatacaat ataaggcata taccttgcag tccttccccc attaaggcta 480agccatggga cttattgcaa gggaaaggga gcagtgatat tagagaaggt cacagtatag 540gtcagtagtt ctcaaagtgt gtttccccaa ttagcaatat caacatcacc tgggaactt 599267599DNAHomo sapiens 267ggaactgggt acaaaggaga ctttatctgc aatgttttgt gtaattttaa attaaacaaa 60ataagataaa acatcaacta ctattgattc taggtgttga tgtctatata ttttcatact 120ctatatttag tttagttttt tttaattgta tttcaatctt tttttttgtc tagcttttca 180aatagaatgt atttacacat ctctaaccat tcatccatcc atccattcat gctacttcgt 240agatatatct tgtgtggctg accagatctt atttcctctg gaaggtggcc tttggaagcy 300gcaattgtgt ttgccaccca agtcactgga cctttcccaa aattccaggc caccacttga 360cctaaccaca ttcatttcga tgcaagtccc tggcattggg tctttatgag gcgcagatgg 420tctccaggtc agcactgagc cctgtctctt tctctctgtg cccagctggc atgaattgga 480aggcagagga accgagggag ttctgagtca cctagcttga ctgagtcaga gatttctcca 540gggagtggtg gaaagggtgg ctcttggcag aagagatcct catctcaatg gtgtggtac 599268599DNAHomo sapiens 268caattctaga agcatcattc aactcttaca gctacttaga gatgctgaac caggttccca 60agccagaaca agttggagta tttgtaccaa cttgttttat ttcacaccaa aatattttgc 120cattgataaa gtatacatca aaatgtcttt agtttaaacc atcccatgta taacatgcat 180gaaaactatc tctatagaca gtgaatggtg taaaaggagt attgggcctt atgaactaga 240agacagagtc tactgccaat gtaacagcga gctctgcttt ccctttcttt ctaacagaay 300cctgattttg tgtttagata gtggccagag gtatctttcc catgcctctt ttatttcctg 360atttaggttt tctgaggtct gatgtctaga gctgtggtag ccagcttgag actgtaaaat 420gacacacata aggaaaaaaa gtcttgttgt aaaaatgaaa cagaggaagt aggggaaaaa 480aagcctgtgt ctttctcagg accattgagt aattgcaaca ttgtgaaaaa ctacttttag 540atttcttgat gtacgagaaa aattaattcc tacttgtgaa aatcaaggtt actaagttg 599269599DNAHomo sapiens 269aattaatttt tctcgtacat caagaaatct aaaagtagtt tttcacaatg ttgcaattac 60tcaatggtcc tgagaaagac acaggctttt tttcccctac ttcctctgtt tcatttttac 120aacaagactt tttttcctta tgtgtgtcat tttacagtct caagctggct accacagctc 180tagacatcag acctcagaaa acctaaatca ggaaataaaa gaggcatggg aaagatacct 240ctggccacta tctaaacaca aaatcaggat tctgttagaa agaaagggaa agcagagcty 300gctgttacat tggcagtaga ctctgtcttc tagttcataa ggcccaatac tccttttaca 360ccattcactg tctatagaga tagttttcat gcatgttata catgggatgg tttaaactaa 420agacattttg atgtatactt tatcaatggc aaaatatttt ggtgtgaaat aaaacaagtt 480ggtacaaata ctccaacttg ttctggcttg ggaacctggt tcagcatctc taagtagctg 540taagagttga atgatgcttc tagaattgga agtaatatgg ctcatagaaa aaaggtgac 599270599DNAHomo sapiens 270ctatttacca gcaggtgtgc ctcttttgtc cagcagagac ctggaagaga gagctgggaa 60cccaatacca gcccctgcta gggctgctgc ttcagctctg acgtgaaagg cttcagttta 120aggtaggaaa gcaatgtgtt ttcttcacaa agctggtaga ctcttatcat ataggcttct 180cagacatctt agattgcagg ccacaggccc acacctgctc tcttagctgt cagaatgact 240agctttagta tgaattcatt tctttcaagt aggactttgc aaaactcagc aataagaaay 300acgcacattt taaatttttc tattacttcc cttgatgctg cagctacaat aagcacaaaa 360atataaatat ttaataacca cattaaaaag gtcatcaact tcgcagcttg taatgggtga 420gacctgtcta cttctctacc ttgtattcct ggagatttca catttttatt ccttttactt 480gcaatatccc actttcaggt accccatttt gcatcagagg agagggtgca ggcaagcagt 540agaaaaccca ctacagtggc ttaaccagat gaggtttttt ttagtctgtg taggctgct 599271599DNAHomo sapiens 271gtctttagca tgtagcttct gttctaatgg ccacaggatg cctattttac atttgcccac 60gttactggta gaaagtatga agaagaattg catgtttatc aggaagcaaa acttttcccc 120agaaattccc agcagactgt tgttatcgac attccattga tgagaactgt ttcatgcaga 180ggcccgtaac tgaagggcat ggggtgctag ttgagttttg tagcttggga caatttttct 240tggaacaaaa tttgaatgct gttagtaaag gggaagaggc taatagatat tgggaagatr 300aatctcaggg tttgttatag ggttcctcca gataggctga ttataacact cacaagcatt 360attcagtaca attaaaataa atcaggagcg gggaaggctc ctaatattct ggatttataa 420gtctttgaaa ttttagttta atccacagaa ttcttttaaa gtttcctcca aaacattttt 480tttctgtatt tctattctcc acaaatattt ttttctgcat cagaacacaa tttgattgaa 540cactaactct gatattcaga gacagcatca gattttggtc actagtacta gtctttatg 599272599DNAHomo sapiens 272ttactctctc ggagtcctca gcatctcagg aatgagctgc aataccacat tgtgccagta 60gatgacgaca ccatctaaca tgtgaggact ccttacccga aatcccttaa atttcaagca 120tcgaattaga aattattttc tgttatcaag tatgttagtt tgacttccta ccagttgatt 180ttagaaatga gaaacatata ttgaaatagt aacattaaat atcagaattt ggtgtgtatt 240tgtctttcaa ttagtggtaa tttctgcaaa atgaaaatca tcttcaaggc aatgcaaatr 300atttattata ggcgagcaca agtttccagg tgaaccaact gttttgtgaa ggagccagag 360gaaaactgat tagatgagtt taactgttgt ggccacaaag tcttatggca gccactggtt 420ttcaatcttg actgaatatt gaaatatatt tgtactaact gcccagatta tattgaaata 480atgtaggcag ttaaaaaaat acctgtctgg ttcttaactc aaaaaacgct catttaattg 540gtctacagta cggtctgaga gtcaagcctt ttaaacgctt cccaggtgat tctattttg 599273599DNAHomo sapiens 273agatgagttt aactgttgtg gccacaaagt cttatggcag ccactggttt tcaatcttga 60ctgaatattg aaatatattt gtactaactg cccagattat attgaaataa tgtaggcagt 120taaaaaaata cctgtctggt tcttaactca aaaaacgctc atttaattgg tctacagtac 180ggtctgagag tcaagccttt taaacgcttc ccaggtgatt ctattttgca gcccatattg 240agaacacctg cccttggctt aaggctccca tcaccccatg ttgcaattag ttgcttaaay 300gggccgatct cacccaaata cagagttggt gattatctac caggtgtaat ctgtgaaact 360aggaaggccc ctgctcctcc ttaggaaaaa aaccatggtg tctgcacatc taccatcatg 420aatgcatttc ttcgttgcac agatagatgg taaaacaaac caatcacaaa ctaacagaaa 480aattcaggag aatcacactc tgagctttat tcaacattgc tattaatttg ttttaattgt 540gtttcaatga atgttctttg tgtgaaaggg acataaggga agagagtttt ggagtttga 599274599DNAHomo sapiens 274tgtctacatc acatataagg caacccaaaa aacaagagtg tgtttcaata acttggccaa 60ggtcactgta ctagtccatt tttatgctgc tataaagaac tgcctgagac tgggtaaatc 120ataaacgaaa gaggtttaat tgactcacag ctccaaagag ctgtagaggc ctcagaaaat 180ttacatcagg gcagaaggaa aaagcaaaca cgtccttatt cacatggtgg cagtaaagag 240aagaatgaga actgagtgaa gggggaagac ccttatatat ccatcagatc ttatgggaam 300ttactatcac aagaacggca tgggggaaac cgcctccgtg attcaattac cttccacttg 360gtccctcaca tcgcacgtgg ggattacaga aactataaaa tgagatttgg ctggggacgc 420agacaatcca tatcaatcgc ttaactggta agtggcagag ctgcaccatt tggggttcca 480accaatgcat ttcacccttc tcattcatgt ttgctgccct tatgaactga atgcctccaa 540gtccgttagc tatatttcct tatttattat ttggaaatgt taatgcccct acatcttag 599275599DNAHomo sapiens 275atgagaactg agtgaagggg gaagaccctt atatatccat cagatcttat gggaacttac 60tatcacaaga acggcatggg ggaaaccgcc tccgtgattc aattaccttc cacttggtcc 120ctcacatcgc acgtggggat tacagaaact ataaaatgag atttggctgg ggacgcagac 180aatccatatc aatcgcttaa ctggtaagtg gcagagctgc accatttggg gttccaacca 240atgcatttca cccttctcat tcatgtttgc tgcccttatg aactgaatgc ctccaagtcm 300gttagctata tttccttatt tattatttgg aaatgttaat gcccctacat cttagagttg 360tactgagaaa tacaaggtac aacatattta aaagtgctca gagcacagca cgaaggtcac 420actgtttaga tcccagtgcg gtgcgtcctg ttattatctt tctgacactt agacattact 480gcctctctag actcattgct atgatctgaa tattttgtct tcccaaaata catatgtgaa 540atctttattt tattttattt tattttattt taccttttct atgtttagat atttaaaaa 599276599DNAHomo sapiens 276aaactataaa atgagatttg gctggggacg cagacaatcc atatcaatcg cttaactggt 60aagtggcaga gctgcaccat ttggggttcc aaccaatgca tttcaccctt ctcattcatg 120tttgctgccc ttatgaactg aatgcctcca agtccgttag ctatatttcc ttatttatta 180tttggaaatg ttaatgcccc tacatcttag agttgtactg agaaatacaa ggtacaacat 240atttaaaagt gctcagagca cagcacgaag gtcacactgt ttagatccca gtgcggtgcr 300tcctgttatt atctttctga cacttagaca ttactgcctc tctagactca ttgctatgat 360ctgaatattt tgtcttccca aaatacatat gtgaaatctt tattttattt tattttattt 420tattttacct tttctatgtt tagatattta aaaaaaattt tccataagac attggggtac 480agatggtatt tggttacagg agtaagttct ttagtggtga tttgtgagat tttggtgcac 540ccatcacaca agcagtacac actgcacttt atttgtagtc ttgtatgctt cgtccctct 599277599DNAHomo sapiens 277gaaggtcaca ctgtttagat cccagtgcgg tgcgtcctgt tattatcttt ctgacactta 60gacattactg cctctctaga ctcattgcta tgatctgaat attttgtctt cccaaaatac 120atatgtgaaa tctttatttt attttatttt attttatttt accttttcta tgtttagata 180tttaaaaaaa attttccata agacattggg gtacagatgg tatttggtta caggagtaag 240ttctttagtg gtgatttgtg agattttggt gcacccatca cacaagcagt acacactgcm 300ctttatttgt agtcttgtat gcttcgtccc tctcccactc ttcctcccaa gtttccaatg 360tccattgtat cattcttatg actttgcatc ctcatagctt gactcccaca tatcagtgag 420aacatgcgat gtttggtttt ccattcctgt gttacttcac ttagaataca tatgttgata 480tcttaatcct caaagttatg gtattaggag ctggagcctt tgggagatga ctaggtcctt 540agtgcagagc accctcatca atggaattag tgcctttata aaagaggccc cagaaaagc 599278599DNAHomo sapiens 278ccagtgcggt gcgtcctgtt attatctttc tgacacttag acattactgc ctctctagac 60tcattgctat gatctgaata ttttgtcttc ccaaaataca tatgtgaaat ctttatttta 120ttttatttta ttttatttta ccttttctat gtttagatat ttaaaaaaaa ttttccataa 180gacattgggg tacagatggt atttggttac aggagtaagt tctttagtgg tgatttgtga 240gattttggtg cacccatcac acaagcagta cacactgcac tttatttgta gtcttgtats 300cttcgtccct ctcccactct tcctcccaag tttccaatgt ccattgtatc attcttatga 360ctttgcatcc tcatagcttg actcccacat atcagtgaga acatgcgatg tttggttttc 420cattcctgtg ttacttcact tagaatacat atgttgatat cttaatcctc aaagttatgg 480tattaggagc tggagccttt gggagatgac taggtcctta gtgcagagca ccctcatcaa 540tggaattagt gcctttataa aagaggcccc agaaaagcaa aatgggtaac tgagatgat 599279599DNAHomo sapiens 279aagttcttta gtggtgattt gtgagatttt ggtgcaccca tcacacaagc agtacacact 60gcactttatt tgtagtcttg tatgcttcgt ccctctccca ctcttcctcc caagtttcca 120atgtccattg tatcattctt atgactttgc atcctcatag cttgactccc acatatcagt 180gagaacatgc gatgtttggt tttccattcc tgtgttactt cacttagaat acatatgttg 240atatcttaat cctcaaagtt atggtattag gagctggagc ctttgggaga tgactaggty 300cttagtgcag agcaccctca tcaatggaat tagtgccttt ataaaagagg ccccagaaaa 360gcaaaatggg taactgagat gatgaatatg ttgatacatt catctgttcc ctgtagtaac 420catcttacta tatatgtatc ctacaacatc atgttgtatg acttaaatgt gcacaataaa 480attgtttttt taaaaaagaa atagttccat tcaaataaat aatttgtatt aagtaaatat 540aaaaggcctc agagagctgc tttgttcctt tcgccatttg aggacatagc tagaaggtg 599280599DNAHomo sapiens 280gattttggtg cacccatcac acaagcagta cacactgcac tttatttgta gtcttgtatg 60cttcgtccct ctcccactct tcctcccaag tttccaatgt ccattgtatc attcttatga 120ctttgcatcc tcatagcttg actcccacat atcagtgaga acatgcgatg tttggttttc 180cattcctgtg ttacttcact tagaatacat atgttgatat cttaatcctc aaagttatgg 240tattaggagc tggagccttt gggagatgac taggtcctta gtgcagagca ccctcatcar 300tggaattagt gcctttataa aagaggcccc agaaaagcaa aatgggtaac tgagatgatg 360aatatgttga tacattcatc tgttccctgt agtaaccatc ttactatata tgtatcctac 420aacatcatgt tgtatgactt aaatgtgcac aataaaattg tttttttaaa aaagaaatag 480ttccattcaa ataaataatt tgtattaagt aaatataaaa ggcctcagag agctgctttg 540ttcctttcgc catttgagga catagctaga aggtgctgtc tatgaattag aaagccctt 599281599DNAHomo sapiens 281cttatgactt tgcatcctca tagcttgact cccacatatc agtgagaaca tgcgatgttt 60ggttttccat tcctgtgtta cttcacttag aatacatatg ttgatatctt aatcctcaaa 120gttatggtat taggagctgg agcctttggg agatgactag gtccttagtg cagagcaccc 180tcatcaatgg aattagtgcc tttataaaag aggccccaga aaagcaaaat gggtaactga 240gatgatgaat atgttgatac attcatctgt tccctgtagt aaccatctta ctatatatgy 300atcctacaac atcatgttgt atgacttaaa tgtgcacaat aaaattgttt ttttaaaaaa 360gaaatagttc cattcaaata aataatttgt attaagtaaa tataaaaggc ctcagagagc 420tgctttgttc ctttcgccat ttgaggacat agctagaagg tgctgtctat gaattagaaa 480gcccttacca gacactgaat ctgttgacac cttgatctta gacttcccag cttctaaaac 540catgagaaac taatttctat tgtttataag ccacccagtt tattttgtta tagcagcct 599282599DNAHomo sapiens 282tcctcaaagt tatggtatta ggagctggag cctttgggag atgactaggt ccttagtgca 60gagcaccctc atcaatggaa ttagtgcctt tataaaagag gccccagaaa agcaaaatgg 120gtaactgaga tgatgaatat gttgatacat tcatctgttc cctgtagtaa ccatcttact 180atatatgtat cctacaacat catgttgtat gacttaaatg tgcacaataa aattgttttt 240ttaaaaaaga aatagttcca ttcaaataaa taatttgtat taagtaaata taaaaggccy 300cagagagctg ctttgttcct ttcgccattt gaggacatag ctagaaggtg ctgtctatga 360attagaaagc ccttaccaga cactgaatct gttgacacct tgatcttaga cttcccagct 420tctaaaacca tgagaaacta atttctattg tttataagcc acccagttta ttttgttata 480gcagcctgca catactaaga cacccagaaa acctccaaaa attttaaacc acttaaataa 540tatgattatt taaacaaaga aaagcatgag caaaaagtct gaaaatttta ttcattcac 599283599DNAHomo sapiens 283gatgaatatg ttgatacatt catctgttcc ctgtagtaac catcttacta tatatgtatc 60ctacaacatc atgttgtatg acttaaatgt gcacaataaa attgtttttt taaaaaagaa 120atagttccat tcaaataaat aatttgtatt aagtaaatat aaaaggcctc agagagctgc 180tttgttcctt tcgccatttg aggacatagc tagaaggtgc tgtctatgaa ttagaaagcc 240cttaccagac actgaatctg ttgacacctt gatcttagac ttcccagctt ctaaaaccaw 300gagaaactaa tttctattgt ttataagcca cccagtttat tttgttatag cagcctgcac 360atactaagac acccagaaaa cctccaaaaa ttttaaacca cttaaataat atgattattt 420aaacaaagaa aagcatgagc aaaaagtctg aaaattttat tcattcactt attaggcaaa 480catttaataa aaatctgata tatactagct attgcagtaa ggatacagag ttaaaagagt 540catagattcc acctgatatg gttcagctgt gtccccaccc gaatctcatc ttgaattgc 599284599DNAHomo sapiens 284taagacaccc agaaaacctc caaaaatttt aaaccactta aataatatga ttatttaaac 60aaagaaaagc atgagcaaaa agtctgaaaa ttttattcat tcacttatta ggcaaacatt 120taataaaaat ctgatatata ctagctattg cagtaaggat acagagttaa aagagtcata 180gattccacct gatatggttc agctgtgtcc ccacccgaat ctcatcttga attgcaattc 240tcatagtccc catgtgtcag gggaggaacc cagtggaagg taattgaatc atggaagtgs 300ttacccccat acttctgttt tcatgatagt gaatgagttc tcacaagatc tgaatggttt 360taaagggact ttaccccgct ttacttggct cttcctcctg ctgccatgtg aataaggaca 420agtttgcttc cccttctgcc atgattgtaa gtttcctgag gccttcccag ccatgtggaa 480ctgtaagtca attaaacctc tctcctttat aaattaccca gtattgggta gttctttaca 540gcagtgtgag aagagattaa tacactacct acaaggagct tatagtaata gctcaggca 599285599DNAHomo sapiens 285ccatgttctt ctgcctgctt ttattctggc cacactggca gctggttaga tggtgcccac 60acagattgag ggtgtgtctg cctctcccgt ccactgactc aaatgttaat ctcctttggc 120aacaccctca cagacacacc aggaacaata cttcgcattc ttaaatccaa tcaagttgac 180attcaatatt aaccatcaca actattcaga gtaactcata ataactaagg tttattgagt 240acttactatg tgccagacat tgtgctccat gctttatggt ttcaaattaa tcctcagaar 300ttccttatga agtaggtgtc cacaatattt ccacacagaa atgagaaaac gaaagcacag 360aaaggtaaaa taacttgttg aagttcttac agctaggaaa gggtaaaaac acatctggat 420ctagacaatc tgactccaga acctggaaag aagcatctaa gtgatcctgg gaggatccat 480gtgagatgct aggaggccat gagctttgaa tatatgcata ttttcatttt taaagcgctc 540aaacaagttt gtgtattgaa atcctgtgat ataagtgttt gctatcttca ttttagtat 599286599DNAHomo sapiens 286aggtcaaggt cataaatgga atgtttatga ctaacataga tgttaggtgc ctcaatgaag 60agtttaaaat tgatgccaaa ttcagtttca ggccctgata tgagctctga taaggtgggg 120tgatggtggg atgggtgatt ctctgtgtct attgtgcagt ctgtgcctaa cggactggtc 180catgtgctgt gctttaggac ctttggttat gtcaattata tgaagacatg ctttttgaca 240tcaaaagtaa cctttcattg gagtccaaat acaggcctac gtatttcata cttggtgatr 300gatttgagtg gtgttcaaat tctcccacct caaatacctt gatagcccca ctcagtaatt 360caagactgaa aatttatcat taatgctctt gttggttcaa tggattgcac cttttaaaat 420gtgaacatcc ctcctagagg ggaaagatca ctttttagaa tgttgtcagt tattgaattg 480gtttaacagt ctcttcctag tcaggtgact aaatgctccc ccaaaagaaa aaaagaaagc 540agaggcttct tatttacaga tgtaagtgtg aactgaagag ttaagaagag tattaacac 599287599DNAHomo sapiens 287atatgagctc tgataaggtg gggtgatggt gggatgggtg attctctgtg tctattgtgc 60agtctgtgcc taacggactg gtccatgtgc tgtgctttag gacctttggt tatgtcaatt 120atatgaagac atgctttttg acatcaaaag taacctttca ttggagtcca aatacaggcc 180tacgtatttc atacttggtg atggatttga gtggtgttca aattctccca cctcaaatac 240cttgatagcc ccactcagta attcaagact gaaaatttat cattaatgct cttgttggtw 300caatggattg caccttttaa aatgtgaaca tccctcctag aggggaaaga tcacttttta 360gaatgttgtc agttattgaa ttggtttaac agtctcttcc tagtcaggtg actaaatgct 420cccccaaaag aaaaaaagaa agcagaggct tcttatttac agatgtaagt gtgaactgaa 480gagttaagaa gagtattaac acagagaggg aagggatttc ttttagttca ttttgtgttg 540ctataaagaa atgcctgagg ctaattattt gacacacaat tctgatgcct ggaaagttc 599288599DNAHomo sapiens 288gtgagccaag attacaccac tgcactccag tctgggcaag aagtgagact ctgtctcaaa 60acaaacaaac aaaaaactca cagaatgaga attcaccctt ccctaagaaa aggcattaat 120ccatttatga aggatctgcc cccatgaccc aaccgcgtcc taggaggccc aaccttgaat 180atcaaatttc aacataaggt ttggagggga caaatatcca aactatagga ggcactaggg 240ccagaaagct cattccacaa ttctgccctg aacacctgca aaggctgatg tcacggggay 300taaattcaat taaggaaggc tttctctttc actgaggaag tgactacata gaaataagtg 360gatatcttgc tgccattctt tgccattcag tctattcgct atccagtagc cagagtaatt 420ttgatgaagt ataaatggaa ttatgtcact cctgtctttg aaatctttca atagctccaa 480gttgtcctta aaattaatta ctgcaggtat ccttcccatg gcctgccagg cctacttgat 540tctctgcctg tttcataaat ctcagtttac accagtctct ttctttgcac tgtagtctc 599289599DNAHomo sapiens 289ctgctcttgc atctggtcct gattcctctc tggcatccag acttgggttt ccagcctctg 60gtccattcca taaagtgctt gttatccctt taatacattc cctatattgc ttaagtaacc 120cgaattgttt cctgttactt gcaaatgaag actcttatct gagaagtatt cccctgtgaa 180tctttgaagt ctcattacat tttaccttgt tttgttgtaa tttgtatatt tgcaaggcca 240gatgctatct

tttaaaagtc tgttcacata tttttttctc ccacaagacc tttcttaatr 300tgtctacttg ttaatttttc tattattcaa actatgactg atggtattaa taaccaagag 360tcattatttg aatatagatc tctcattttc ctttcaagac tccaacagaa ttaaatcaac 420tttcttagtg gaatgatagc tggctgatct aactagtttc attaactaaa ctcaccagaa 480agacatatgc aaaccgccta ccaggtaaag atatttaaac aagtaagagg tcttctcaat 540atacaacgct ttacattccc agaggtaacc aaacaaggga gacaaggatg tcagattga 599290599DNAHomo sapiens 290ttcacatatt tttttctccc acaagacctt tcttaatatg tctacttgtt aatttttcta 60ttattcaaac tatgactgat ggtattaata accaagagtc attatttgaa tatagatctc 120tcattttcct ttcaagactc caacagaatt aaatcaactt tcttagtgga atgatagctg 180gctgatctaa ctagtttcat taactaaact caccagaaag acatatgcaa accgcctacc 240aggtaaagat atttaaacaa gtaagaggtc ttctcaatat acaacgcttt acattcccar 300aggtaaccaa acaagggaga caaggatgtc agattgaagg gtgcttaatg gagtctttca 360gggatttcct cctggaaggt caaagaacac tctacatctg tggcagccca acctacctac 420acacaggctc tgaatgaata atagatgttt tatatgcagc ctccttgacc ttgaatttat 480tatttccatt ctataggtaa agaataaatg gctcatggaa cttcaatgac ttggaacact 540gtattctgaa tttatcaagg tctctaaatc ctgatctttt tccacctaac ctcattaaa 599291599DNAHomo sapiens 291tcattatttg aatatagatc tctcattttc ctttcaagac tccaacagaa ttaaatcaac 60tttcttagtg gaatgatagc tggctgatct aactagtttc attaactaaa ctcaccagaa 120agacatatgc aaaccgccta ccaggtaaag atatttaaac aagtaagagg tcttctcaat 180atacaacgct ttacattccc agaggtaacc aaacaaggga gacaaggatg tcagattgaa 240gggtgcttaa tggagtcttt cagggatttc ctcctggaag gtcaaagaac actctacatm 300tgtggcagcc caacctacct acacacaggc tctgaatgaa taatagatgt tttatatgca 360gcctccttga ccttgaattt attatttcca ttctataggt aaagaataaa tggctcatgg 420aacttcaatg acttggaaca ctgtattctg aatttatcaa ggtctctaaa tcctgatctt 480tttccaccta acctcattaa aatgttgatt aatgataaga ggtagcagat gctaaaagga 540atcatcatag ggagtgtcaa gtgaagactg aattctaata ccagccctgc cactgtcca 599292599DNAHomo sapiens 292tcctgatctt tttccaccta acctcattaa aatgttgatt aatgataaga ggtagcagat 60gctaaaagga atcatcatag ggagtgtcaa gtgaagactg aattctaata ccagccctgc 120cactgtccag ctagttgggt caccttcggg cagtcactca gtttgttaca ggctttagtt 180ttattattta tattaggttg aagtctatga agttgctgtt tttgcaggtt acaaaaggtt 240agagttcaac aatttgagta aaatgagact gtaggatgaa tataacaaca tgatttgttw 300ttgtctatta ttttccataa ttacaatttg tgctatgatc taaatgtgtc cttcaaaatt 360catatgttga aacataattg ccagtgtgat aaaatgaatt ataatgtaaa aagatagagc 420ctttaggagg agattaagtt atgattataa atggaattac tgaccttata aagagctgga 480gggaactaac taggcccttt attgcccttc tgccttctgc aatgtgaaga cacagcattc 540atgtcttttg tccgtttgcc ccttctgcca tgtgaagatg caacatgaat gcctaactc 599293599DNAHomo sapiens 293aagactgaat tctaatacca gccctgccac tgtccagcta gttgggtcac cttcgggcag 60tcactcagtt tgttacaggc tttagtttta ttatttatat taggttgaag tctatgaagt 120tgctgttttt gcaggttaca aaaggttaga gttcaacaat ttgagtaaaa tgagactgta 180ggatgaatat aacaacatga tttgtttttg tctattattt tccataatta caatttgtgc 240tatgatctaa atgtgtcctt caaaattcat atgttgaaac ataattgcca gtgtgataaw 300atgaattata atgtaaaaag atagagcctt taggaggaga ttaagttatg attataaatg 360gaattactga ccttataaag agctggaggg aactaactag gccctttatt gcccttctgc 420cttctgcaat gtgaagacac agcattcatg tcttttgtcc gtttgcccct tctgccatgt 480gaagatgcaa catgaatgcc taactcacca taccctgaat ctgcaggcac cttgatcttg 540gacttcccta tgtccagaac agtaagaaat aagttgttat aataaattac ctggtctca 599294599DNAHomo sapiens 294atgattaatg gtgatgacat tgcaaggtca ggcaagtcag ttgattcctt gggagctgca 60ttacttagta ttgacatggg atgattccac ccaaccagaa gcacagtatg ataattttct 120attgtttcta tgcaatacat caaggcttta aaacttgcat accgaaggca aggaagcagt 180gaatgctaga atagcacact gaaatcttac ttcatgtgaa aaattaaaat aaggataaac 240aggaagaacc cagggaattg atctgaattt cattttcctt ttgcctttta tcccaattay 300aggaccattt ccaggagtgg ctgtctcatg gaaagcccag gagtcttttg ttgtaatcag 360gacaggaagc ctaatgcttt aggatgctgt aattacgttt tccatgagtg ttttctcagg 420ggactggctt cagaactcag aaaattctcc tcaaggaaat gaaattgttc tgatttaaaa 480ctcatggttt ccactgaaac tcgagtggtc tttagcttca gaagtttagg acaggaagtg 540atgggtagaa ttgaataaac ctgagggtga atgaagtggg agatgccatc ttttaactg 599295599DNAHomo sapiens 295tgcagcaaga aatcagagaa ataatgagaa tggctttagg ttctcataag gcaagtgtgg 60tagattatct tttccaagat ggccctaaca atatttctca ttctacatgc gtttttgcaa 120tgttacttct cccactctgc cattaggaaa tgagatctgt ttcccatacc cttgaatctg 180gctggatgac ctgaagcaga agtgatgcca tataacatct aaggctgggc cttaagagat 240ccctgccttc tgacttcgct actgagaata gttctccttg gaaaccagct accatataak 300aaatcatgct accatgagac caccattttg tgaggaagtc caagctacac atatgaagag 360aaacaggata caagagaagc acaaaaatac aacatataaa tacgtaaata aagccttctt 420ggacctctaa ggaactaact taactcagtt gactgagtga cctggccaat gtcaccagta 480aggcctgctt gaattcttga cccttagaat catgagcaaa taaaatggtg gttgtgttaa 540gtcactacat tttggtatag tttgttacac tgcaatagaa atggatgaag aactcagca 599296599DNAHomo sapiens 296ttcttatatg gtagctggtt tccaaggaga actattctca gtagcgaagt cagaaggcag 60ggatctctta aggcccagcc ttagatgtta tatggcatca cttctgcttc aggtcatcca 120gccagattca agggtatggg aaacagatct catttcctaa tggcagagtg ggagaagtaa 180cattgcaaaa acgcatgtag aatgagaaat attgttaggg ccatcttgga aaagataatc 240taccacactt gccttatgag aacctaaagc cattctcatt atttctctga tttcttgctk 300cagagcactt catgggaatg actgaaggct taattgcaac tgcacagcaa ttccatgtct 360ccctctgctt ccccagcttc ctctatgaga ttgtggctga gaccactccc tagtaaactt 420cctgcacaca attctccacc tcagattctg tctcttggga attaacctaa gaaaaatgtt 480ttcgtgtatt tttccctagt gagagaactg ctcttctgtc agagacatct ctttattctc 540taggaagata agcactaggg taggcatgca aaggagtcat ttttgaatat ccaaattag 599297599DNAHomo sapiens 297aacactttaa aaaatagcta gaggaaagag agcaaaccag gagcagtggc tcatgcctgt 60aatcccagca ctttgggagg ccgtggcagg agaattgctt gaacccagga gtccgagtcc 120agcctgggca atacagtgag attccatctc taaaaacaga aagagaaaga gagagaagac 180atttaataca cacaggacaa ctaaacaaag gcacattggg aacaataaac taagagccca 240aactgaagtg gtagctttgg atttagagaa agaaatagtt caatggggta taaataacay 300aatttagtga tttgttgaat ttggagagca agagagaagg aggggtctag gacaacccaa 360ggtttgtatt attaagagag atggtaaatt tgtgagagtg tgtgtgtgtg tgtgtgtgtg 420tgtgttagca taagactaaa cagctttaaa aagataactg acaataatcc agtagcttac 480ctgagatagg cctttaaata cagcttctta caccttagtt caaggtcagc attccaggtt 540ggtgcgtagc tctgcttctt attcagtaac ccaggttcct aggttgctct tccattcct 599298599DNAHomo sapiens 298aaaaatttta atactgactg ctgataaaac tctaaaatta acatttcttc catccctctg 60tctttccttc attccttctc cctctcacac attgccttga aggagtaata cttgatagat 120agtaaaaaaa ttaaagtaca aaggtatatg gtaaaaacag gttgatggct catcaccagt 180ctcttgtctc tctccccata ggcacctgct ggggaacagc caatttaatg tgaatcattc 240tagatatagt ctatgctata catgtgtata tacacagatg ttaaattttt aatttttcts 300aaaggtttgc atatcacaca tactttttga accttcatta tcacatcata atatacatag 360gagagtttct gtttaggaat atttatgttt aacagctgtg actgccattg cgtagatgtg 420gcagcactga acatatatcc tactggtgaa aatttaggtg gtttttactt ttatgttact 480acaaacatgt ggtaatatat actctagtat atattcttca tacataaggg ataaatatct 540gcagaataaa ttcccaaata tgtaattgct ggggaatgaa gtatgtatac ttaccattt 599299599DNAHomo sapiens 299tatcaaattt tcatgcggtg tttggttttt tgttcttgcg atagtttact gagaatgatg 60gaccagcatg gcacatgtat acatatgtaa ctaacctgca caatgtgcac atgtacccta 120aaacttaaag tataataaaa aaaaaagcta ccaaaaaaaa aattttcatt ttttctgtcc 180tgattgaaaa atctggactc ttttagtttt attttgcatt tatctattat aaataaggtc 240cagcattctt tcattattat aagtgccatt tcgatttgac tttttatatt ctttgcctay 300ttctctattg gacggttgat tggtacaagt ttattatatt aatgacatta gttcttatta 360tcttttgtgc tgcaactatt ttttcctaat ttttagttat tgtttgaacc aatttatgtt 420aaaatttttg tttttaggaa gccaaatata tcttatttta attgcttctg gtttctgttt 480gattgttcag agagagaata agagttcaaa atgtttctct tattttcttt tagcaatctt 540tagtaacctc aactaccttt taaaatccac gttacacaaa aaatgcttta cctgggatg 599300599DNAHomo sapiens 300aaacacttca gtgtcatctt tgccagagag taagtatgat tttttgcaat gtccattata 60ttccactggt caatttgcta atctgtgtgc caatactact tttgtcttaa gtaatatacc 120ttttaataga tattaatatc tggttttgta atatctctag tttcattctt taaaattgct 180gtgactgtat ttagctcttt gtacctctat gtgaattttg aaaccagctt gtcaggtttt 240tttttttttg aaaataaata aataaaatac ttcctaatat tttgactggg acagaactam 300atgtatatac taatttaaga agaattgaca tcaacatctt ttcaccatgg agttttccaa 360tccatatgca tggtttatta ctcttgtcat gcatttcttt tttctttttg agacagggtc 420ttgctctgtt gcccaggctg tgaatatggc tgactgcagc cttgacctcc tgggttcaag 480aaatcttcta cctcagcttc ccaagtagct gggaccacag gtgcatacca ccatgcccag 540ctaatttttt aaaattattt ttgtagagat gaggccttgc catgttgtcc aggctggtc 599301599DNAHomo sapiens 301tgtcaatgat tttgtgtact tctaattcct ctctgtcttg aacttctgag cctcataaaa 60taaaaattac ttattaggaa aaaaaaagac aattgaaacc agaccctgag gttgtacctc 120gtaaggttat aggggactag ctttgggaga gtataacccg agatacagca cgtggggatc 180tccaggggca gccctgcagt gatagccagg gatcttgcaa aacccacgct gaagaacagc 240aacacaggtt ctgtaaggtg aagcataatc agtgctacaa ttaagaggat tttccaaaam 300cttttaatgg agaacatgta tagcttgcca aaaaggatga aaaacaagca gtaacactca 360gtaatcaggt ttttatgcct tagtagatat tcacactaaa aaaaatttta ctcatttcat 420gttttcactt tttattacat ctatattttt tcaaatgtac atttctctcc caatcccagt 480gattaggatg caattcaatt ttttttctat tttggatagc ttactgctgt cacatgaata 540aacttgtaaa atgtgcgcac cttttctttg ccttataaaa aaaattaatc tatcggtta 599302599DNAHomo sapiens 302acttgaccct gaaacacaga ctatggggga agggcattcc aggaagggtg aatagcactt 60gaataaaggc atgagatgaa attggaaagt gtgaacattt tagaagaaaa aagggagaaa 120atatgttggc agggatggtt gaaaaaagag aatagaaaag gaaaaacaaa aaagtaaatt 180cacctttttt tttttttttt gccaaagggt tgtggattag tacttagctg acattctggt 240ttaactttgg tatataaccc tgaggtaatc ataaccattg ccatggttat ttaccacaay 300cataaccaca atcacaatca tacccatatt cactgaatct ttgtgaaata acagatctgt 360ggctcttaac tctatcaaac tagacacccc attcactgtt ctttgattaa atttaggaat 420attaaaacct gaaaatgaca tacctttaaa atcaatataa tgccctaact ttattaaaaa 480tagaaaatag ttcataaaat tatatataga tatgtaaata ttaaataaga ttacaacaga 540aaacatactg agcaagctag atatatgcac tttttcaaaa tgaacaaata tggattaag 599303599DNAHomo sapiens 303tctgttacat atttgcacat gaactaagca ttagaaggca ggccaatagt agtgtagtgt 60atgggcaact caaaatccac tagcagtgtt gctctccata atgcgatttc ctaaaataat 120ggtcaatatt tcagttgtgt ttttgaaaag tattcaaacc atgagaaata ttttgtggtt 180atattttaaa gattttgtgt gtttatatgt caagtgtttt aaactcagct aattataaac 240cattctttca attgcataaa catctgtcaa ggtgttggaa agttgtgttt atgtgagacr 300attcttcaac gtgcacaact gttccttgca ttgcaggacc cctaacattt ctcactctgt 360ccactaaatg aaagtagcaa ccactgttgt tttctctgct tttatgagtt tgacagctat 420aggtatctca aatacttcat gatttcattc atttttatga ggtatccata atcattaaac 480tcatgaagca gagaatacag cagtggttgc cagatctggg ggttggggaa gtggagagtt 540gttcaatggg tataaagttt cagttacact agctaagtaa gttctggaga tctgctgta 599304599DNAHomo sapiens 304aagagagaga gaaacaagag aaaagaggca ataattaaat actagagaaa aattctctag 60cttcaagaca gatttgattc tgcaaattga aagttctcac taactttgag caggagtgac 120tggtaaaaca tgtccaagat aaagaaaaaa attaacaaca taagtttcaa aacagaaaga 180atcagttaca aaagaaaaat gaaacagact gacatcagat tttttatctg tgatccttga 240agctggatga catttaaata actccacagg ctagtgagag aaaagatctg tgacccaatr 300agcaagaaat cacagatggt atccacacac atctcttcca atgagaatac ttaaaaaaac 360aaaaaacaaa aaaaccactt tagccaaaga aatgaatcag aacagaaatc ataatgtaag 420gaaaggtgag gaagaaagaa aatgatggtt agaaatgaac tttgcaatat atatctctct 480atataatgag agaatgactt gaaataataa agggctttga aataaaatgg aactctaaaa 540taatacagat taatagttta taattaaagc acaaaatatt tccctgtaac ctttgggtt 599305599DNAHomo sapiens 305tgatacattt cacctagttt tctaaatgtc tggcataaag gtaataaaaa tattttccta 60tgattcttgc tctaatataa ttttaaattt cctttgcact tacaatgttg tttatccaca 120tcttttctag ttttcttttc attataattg ccaaatgttg aatttaatgg tctttccaaa 180aacagttttg attttgttga ttggtgggac agatcctgag gaagatgcat actctctgat 240aagccagagg tctctgtagc atcttcaatc aagggaggtg caatagcctt taatagggar 300gaatgggcca cttctgcagg tggttcaggg aaactggggg tttcaaattt ctttagtgtg 360tcaaccaaga agttcccatc tcaagactcc ttccaaaaga ggacctgacc tgggtttaga 420agcacttcca agattgagaa ttcagtgttt ttgcaactgg ccagctttac aaataagtcc 480tgtacctgat ccaccactct ttctgctatc cagctgcagc agttgagagt ttcttcaaaa 540gctgccaagg aagcccacca gctttctcac tttgcctgta gttcatgata atcaccctc 599306599DNAHomo sapiens 306aaagctttta ggcttcctgg attacctctt ctaacaattc acagccaaaa aacactccta 60ccaaagccta gaagaagata atatatttaa ttttgtaaat gttgaacaag gaacgaaata 120tgttttaggt cagaagatac agctgaggcc atattgaaaa gagagattaa gtgaaactct 180gcacgataag tagcgagacc cctgagggca cacgctccca gaatgttgag aaataggttt 240atgtctattt tgcccctagc catacaacta ttggtggatt tttcactgaa caaaataaay 300aacccaagga gggttatata tataacacaa aatactacaa ataattccct ctatatgata 360ttcaaggaaa ggcaaaactg aagtgacaga atgcagatca gtagttctcc agggctaaag 420tgggagggaa tcaaatgcaa aagactctaa gggatttggg gagtgatgga aaggttttat 480atcatggtta tggtggtgat tacaggattt tattcatttg tcaaaactct gaattatact 540ttttaaattg ataaatttta ttgtacctaa gttacatctt aataaaaaca attaaaatt 599307599DNAHomo sapiens 307agacccggtg ctgccttagg acaaaaatag ggccacaagt taagaactac ctatgtagtg 60tgacagatcc cctgccaggt tgtttaaggg tacatgtcca ctgcctgaac cctgaaggcc 120aggcaatgag ccaaggccat ggtgtatagc tgaggaatag gtgtccctgg gaacccaaac 180atcctggaga atagctgaga acctaccaag ggaaacagtc ccatcacaca cacatagtag 240gtaaagagac agaaaattag cttagagatg ggaggtggca cagatctcta aagctgtccy 300gctgccattc aggagtgcct catgcataag tcctaataaa ctcatctact agccaagctg 360aacttgtccc agacatgctt ggtctctttg ctccctccca gtttggggta aggttttttt 420taaatacaat tccaggtttt tctcattaca attgctgtca tgagcaggat ctgagaaacc 480aatggatgaa ttaggaaggc gcatctgcgg ggagaatcct agggtggttg gcaacatgca 540tgtggcgtgg agttgcccga ctgctcaatc ttcacaggcc accgtggact ctgggaaaa 599308599DNAHomo sapiens 308ccatgtccca gaagccattc ctacctagta tgaaggctac cacatagttg gagatctggc 60ccatgcccac gatgacaaat aacacagtga acatctccca gctgatggag aaaatctgca 120ggaagctgaa gccagtctgt acagccatgg ttgcgaagag aacgttcttc ctgccaaacc 180tagagaatgc agtataacac aaaacatgag atgtgtaggt tgccaaggtg tgttgcaagc 240cctgagtcag gcatcaatgc agacttagtg ttttttcagg gctctggcag acttttttcy 300ctgtcacatc ctcccatctt cctccttggt gaggtctcag gcatccatct gctcaggaga 360tatcttttga gattctcagc ttcctgtgga gacaccatgt ctcaaaagca tggagcagtg 420tacgcaagga ccttgtggaa atatgctctt tagaaggagc cacagataga tgctaccagc 480acatttctgg aaagtgggta cagcacagat tgcagatatt tcttgaatca gcaacatgaa 540aattctgtaa atccagaact aagagtcact ctgcaagtgg tttttaacct tggctgcac 599309599DNAHomo sapiens 309ggctccagaa tcaccctgtg ccactaaaaa ggcagatctc agtgctgccc attctataga 60accggggatg ccaccacctg gcacaagtcc caccttgttc ccattcccac ggagagagct 120tctctggctt caccgtgact ctctaccctt ctgttccaga tggtccttca ggtcctcctg 180ggatatgggc ctgctggtca gagtcctccg ttttggggag gcctgtttgg cttttggtat 240gtgtctggcc caagcagagc cacatgttgg gtttttcagg cttagggagg atcgtcacay 300ggaagatgga ttctggggac tttgaacatg aagacaatag gctttgcctt gtgttcttgg 360agccactggg gactaggagg ttgcaatttc tatcttaagt tcctccaacc tccagtttcc 420aacaacactg gcctgaagct ccctgtgccc tctacacaaa tgatcttcaa gaaaatcttg 480ccccgctcct tccccctgca ggaaggggag cagcctcctc ccgctggggc ctgctgaaga 540gtgtgctacc tgctgggacc atgtggctcc agcatgttct tcccaccttg tctcctccc 599310599DNAHomo sapiens 310gctctcagta gaccccagct caagaaacaa gactgtagtg cagctgccag gatatgaggc 60gagacccagg aaccatgggc taggagtgtc ctccatctgg cacggggaga acctgggttc 120cttgatgctg agttgctact agagtgactg tgataagccg tctttcatgg agatattatt 180atgaagactg agatcatgta tgcaaagtgc ctaggagggt gtctggcatg tggcaggtgc 240tcagtaatag ttattcttta tcctgatcaa gcagttgaaa tgtgctacat gtcaggggar 300tgatggaaag tacaatgctt ttgatccaaa aaggcccagt ggaagacaga actcctcttc 360agggcttaac agatgttccc ctgctcaggg cttcccctct gtctgcacca atcactccag 420tcaaaagtaa catttcctat ctctgtgtat acccagcaat atgtgcccca ctcccttgac 480ccatgtcccc atgtccacag tgacagctgc attggctgca gaggcacaac caggcagtga 540gctccttgtg aatagacagg agtaagttct tgctcttccc tgggtctccc cagttcttc 599311599DNAHomo sapiens 311tgtcataaaa atatcatgcc cagccccaag agctaatccc ttctgagaat gccacatttc 60caaaataaga gccccaacat gagaagcaga gagagcattt caggagacaa gcagtggctc 120ttctgagggg ccatgtgggg tcaaggtgtg tgtagccttt ccaacagttc tgaactgtaa 180ataaacagac attggcccat caggaagcag tggagagttc atcatttcca agacctcagg 240gcacacttac ccatgcctga gccctgagaa atcagttgga gtgagctggc tctggaggtr 300cacagacagg ccttcctgca gcatgctgtg cccagagatc agcccaggca gacacagtcc 360acagtccatt tggaccaagg aaagaaaagc aggcgctgtt ctgctgcccc tgcaggcagc 420agccctagac ctgtccacac acccattgaa ctcacagtgc tttccctgaa cagcagaaag 480gcccatgact gcttggtgcg ggcactgctt tttgggaaag gacatgcagg cgactattgg 540cctctgctct gctcagtgcc acagtgagca gagatggcac cagatgggag tccaagaac 599312599DNAHomo sapiens 312ccttagggca cagtgagcag gctccctgtg ggatggacct tctctgctgg aaactctgga 60ggctgactct ggagggctaa tggatcagag ctgttcgttc ctcgctgtga catatggtcc 120cgaggcaaag atcccatccc tactaatctc tgtacagccc atcagaggct ttatattgtt 180attctctctc tctctttctc tctgatagaa tcatacctta atcagattga ttataacttt 240ttttttgaga cagcatctca ttctatctgg gctggagtgc agtggcatga tcatatagck 300cactgtaatc ttgaactccc aggctcaagg gaccctccca cctctgcctc ctaagtagct 360gggactacag gcgctcacca ctgcacccag ctaatttttt atttttagta cagacagggt 420tttgccatgt tgcccaggct ggttttgaac tgctgggcta aagtgatcct cccaccttgg 480cctcccaaag tgctgggatt acaggtgtga atcaccatac ctggctaatt ataacatttt 540gaaagtactg gtctcttagg tcaaaatgac aactagagcc agagaacata gtttattaa 599313599DNAHomo sapiens 313aggcggcagg gtccatgtca gctctaagca tccctccata ccccaaccac tagactgatg 60agcatccctt tgggaagacc cacctgcaag gatgggatgt tcagaagaaa gctattttct 120tttataggaa aatggtaaga ccactggtaa atgttcaggg ggagcactca gcttgtcagt 180gctggtccca

ggctggcctc tgtctggggc aagtcctgtc cctggtacag tatgcccaca 240gccaggagca ttcatggacc agctcctggg gaatagaaga aaaagctctc cttagggcas 300agtgagcagg ctccctgtgg gatggacctt ctctgctgga aactctggag gctgactctg 360gagggctaat ggatcagagc tgttcgttcc tcgctgtgac atatggtccc gaggcaaaga 420tcccatccct actaatctct gtacagccca tcagaggctt tatattgtta ttctctctct 480ctctttctct ctgatagaat cataccttaa tcagattgat tataactttt tttttgagac 540agcatctcat tctatctggg ctggagtgca gtggcatgat catatagcgc actgtaatc 599314599DNAHomo sapiens 314tttgggtcat tgggtcattg ccatggaaag gggcaataaa gcctgagtgt tgtcatggca 60acagtaaact gacatggcac acgggtgggc gtgtcttatg gaaagcgtct tctgccctgg 120ctgtgtttta gctggtcctc aatttggtcc agtgtccaag ccctgcctct ggagtcgtgt 180ctggcctcct acctcagtag gttaggtgta ttgacctaga atattctcaa tttacaatgg 240gcttattggg atgtaacccc attataagtc aaagagcatc tgtacttact tagcctagam 300aacaaattat aagtagcaga cacagagtcc tgtgtagtta attggcccca aacccacact 360aggaattagc tcagagcaaa acaaatgacc aaccagcagg tcccctctcc agcttaatag 420cacatgagtt gaaaaatgag cctagtttgc atttttcaga atatgccttt agtgggtccc 480tataggaact acaataatgt taggtcactg actctcagta attagaactg tgctgtccga 540tagaaacttc tgaaatgttc tgtatctgta ctaagacagc acccactaac cacatgtag 599315599DNAHomo sapiens 315cagctttatt gaagaggcaa tgttacagct ccgtgactgc tcctgcagag cagggctgcc 60ccacaggcag agagtagcag ctcaggacag ttttgcactc atatttataa ctacttttaa 120ttacatgtag atgaaaggtc agtttatgca gaaatttcta gggaaagggt agtaattttt 180gggtcattgg gtcattgcca tggaaagggg caataaagcc tgagtgttgt catggcaaca 240gtaaactgac atggcacacg ggtgggcgtg tcttatggaa agcgtcttct gccctggcts 300tgttttagct ggtcctcaat ttggtccagt gtccaagccc tgcctctgga gtcgtgtctg 360gcctcctacc tcagtaggtt aggtgtattg acctagaata ttctcaattt acaatgggct 420tattgggatg taaccccatt ataagtcaaa gagcatctgt acttacttag cctagacaac 480aaattataag tagcagacac agagtcctgt gtagttaatt ggccccaaac ccacactagg 540aattagctca gagcaaaaca aatgaccaac cagcaggtcc cctctccagc ttaatagca 599316599DNAHomo sapiens 316aaattttttt aaagtgtgtg tgtgtatata tatatatata tatatatata tacacataca 60cacatatata tacacattta tatatgcgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtata 120tatatatata taaaggcact gccagaacca tgtgttttaa cactgaacta tattcttatt 180tgtccataac tatatatctc atatctattt tatgattgct gtcatccaca taggtagatc 240cctacaacta gactctaagt ttcacagata ggaatcaggc cacctagctg ataaataccr 300ataaacaccc cagcacagcc ctgaagggca gaagtgttag acactcccaa tgttgttgtt 360gttgttgttg ttgttgtttt atccatttaa attgactgag acttgaaatg gacttcttga 420tttgaagggc aaaggattaa gggatgtttt gtcctggcag ccctctgaga gcttgagttc 480atggccagtc taagcctcta gccatagcca gagtatctgc ttctggaaaa ggtcctgaag 540gccagggact ggggaagccg tgggggtgag cagtggcatg cccaccgtcc tctacagag 599317599DNAHomo sapiens 317ccagacatct tcttggaggg ttccagggtg gtgcacacag acaggacctg tggaccagtc 60ctgtgctaat acttggtggt tccacggggc ccttcttaaa tgcaggttgc caggttcctc 120cctgggcttg cctacttcga ctcttttaaa cagaggcctg agaatctgta ttcttaaagc 180acttgggtga ttgtgatgag cagccaggat tggaaacctc agaacaagaa tatgcttgta 240tccagtggtt gtccctggcc tgggtggagc caccaaaatg tctttggatc aggtaccagr 300agcaggttga aggtgcttct tctgaagcca aggatgcttg agattgcttt ctaagacaat 360actctactct atatcttttc ctatccaagt taatgctact gcctgtaaca tgaagtgaaa 420aatcacagtt gttaagagca tgtactttgg tgcctgggag aactaggtca caaatcccag 480tttaacatct gtgtgatcct gggcaagtta cttaacttcg ctgtgcctta gtttcttttt 540ttgaaaaaaa aaaaaagcat gagcaatgag cagaacacag tgcctggcat ttggtaggc 599318599DNAHomo sapiens 318atgaagtacc aggactttgt gactttgtgg ccctacagtg catgcgcagt aagagactga 60tggaggagtt tttattatga agaagtggga gtgccaggcc tgccttcaca gcaggtcctc 120tccaaatgtg agtgtccttt tttctaggaa tgatcagaca cttacacagc tcacagccac 180attgcctttt ctctcttgca ctatttggat tgtagagccc cagaacatgc ccccagcaga 240ataaccctgg tattataaca aagcaaagcc actgcataaa ctagtgggaa ccagacatcy 300tcttggaggg ttccagggtg gtgcacacag acaggacctg tggaccagtc ctgtgctaat 360acttggtggt tccacggggc ccttcttaaa tgcaggttgc caggttcctc cctgggcttg 420cctacttcga ctcttttaaa cagaggcctg agaatctgta ttcttaaagc acttgggtga 480ttgtgatgag cagccaggat tggaaacctc agaacaagaa tatgcttgta tccagtggtt 540gtccctggcc tgggtggagc caccaaaatg tctttggatc aggtaccaga agcaggttg 599319599DNAHomo sapiens 319taaaaagtca ctttccttac atcagacttt gctcttgtta attggacgct gcaagctgtg 60agtgactgaa cctgagtttt tgttacaact gcactatgca gacacccctg tgtagaaatt 120tgcttattat taacatgact gagaagcaga ggatatctga aaaatgactt caggaacact 180agtggatctt tttacacata ctagacccaa attagataat acaaggacta attcataaac 240acaacaaata agtatgctca agggatctta gtgattttcc catttagtaa taggagtagy 300ttagatagaa ctagtgacta attttttatt agcttagtag caccactacc caagaacatt 360tgcatcaggg atataggctg aaatgtaaga actaagaagc ccatgtacct aggacacact 420tgcttaattc agacgcataa gctctgtcat tgatctcttc taattgccaa gtaggatggc 480ccttaaaaat aaacttagat tagctgcagc ctaaatctac cagttctgac gatcatcgtg 540tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgctgcca tcatagagta ggaattttc 599320599DNAHomo sapiens 320taactgagta cccccatttt tctaagagat agtttatttt ctctctctct tcttttctct 60ttcctccttt tctgcacttt ctacttagct ctttagaagt gcaattatag ccttttaacc 120tcctcttcac tggacactcc ctgcagggca aattcatcta actatgtgct tagaagctcc 180agagtggaac tctcaccgcc cagatttcct caagcgatat cagtcaattt ccaactcaaa 240gtatgcctgc tagagttttt ggccacctat acaacctgtt tctgcccatg aaggcaccam 300ctcaactgcc cagtagataa ggcagcaagc tagccctctg atccctcacc tgctcgcgtc 360ctcccctgcc ttttagaagt gcctgctttc cgcttcaaaa agaggagcgg tggtaccctt 420caggcaggaa gccgatacct ttctccctaa gctagctttg gaataaaaag tcactttcct 480tacatcagac tttgctcttg ttaattggac gctgcaagct gtgagtgact gaacctgagt 540ttttgttaca actgcactat gcagacaccc ctgtgtagaa atttgcttat tattaacat 599321599DNAHomo sapiens 321gtaggcatct ccatgtaaat taggagcatc cagagacaga gcaaagtaac ccactgaggt 60cagcatcctg aaagaagaag gtaaaaatga caaagggatg gtgtgaatcg ctctaaaatt 120ttatgatggt caagaaattc tctatatctt gctgtcttat aagtagccac taccctcatt 180ggctacttaa atttgaataa attaaaatta aataagatta caaattcagt tccttagtta 240cactagccac acttcaagtg ctcaatagcc acgtgtagct agtggctact atattgaacr 300acatagatat gaaacatttc cgtcactgca gaaagttcta ttggacagtg ctagtctaga 360tataccaata ttcaacaata acttttctca gctagttgat ttcaagtttt cctatttcct 420gaatagtttg tacctcctca atctcttaga gctattatat gaagaaaaaa tattagtcac 480atcagtgaac ataaaatcca gatttcattc tttaacaaaa aagagataca agggtcatac 540tgtgggattc acttagaata aattctgatt ctctttaggg aaaagagtga atgtcccct 599322599DNAHomo sapiens 322atttttttat ttttagtaga gacagggttt caccatgctg gccaggctgg tcttgaactc 60ctggcctcag gtgatccacc taccttggcc tcccaaagtg ctgggattac atgcatgagc 120caccacgcct gagttgcttg tgtgtttaaa aaattatata catacctgtg tacatgatgt 180tgtgcaaaac aaaatgtctg tagcgctact caccagtttg tgattggctt tctagagctc 240ctcctgggag aggagaggtg aacttgtact tttttccagt acattctatg ctatttgacr 300ttttcacaat gaaaatctta cttttacatt gaaaactaat ttaaaggaag aacaaatgca 360caagatgcag ctcaccgagg taaacaaagt agggggcaat gatgctgccc actctggagg 420ccgtggatgt gacccccacc gccatgttcc tgaccagggt tgggtagagc tcagcagtga 480agacatacag catggagaaa gcagaggtga tcccaaattt tcccagcatg accagaccaa 540tggataagaa gtaataatct ggaaaagaga cccggtataa acaatggtgc ttttagaag 599323599DNAHomo sapiens 323gaatggattt aaatctgaac attttcagag aaaaaaaagt aagcaaaata tcagtttctt 60tttggcagat gacattgtgc atgtctataa tccttttgca ttatcataag gcttttcatt 120ctttcctgtc aactggtatc ctctaagcta ctactcagtc atgtgtgaca gatgttcctt 180tggtagagtt ctttgcctac cagagttctc ctcttaaggt ggaggtaatt ggaaatgggg 240gatgggagga catcaaggag aaggaggtta accaggatgt ttcagggata ggttttggcy 300atgataggtc tggcatgact ctgcttttgc ccaaactagt aggctgcagt ggaaagttag 360gtccacaggg ctatgagact caaaaaaaaa aaaaaaaaaa aaaaaaacaa ctaagtatta 420tgttcacttc agattaaatc agtaaattat aagtatcagg cacattctgt aaaggcactg 480tgtgcctgga tttggcttct ttttggagca cttacatgtc ttgggttaat atgtaatctc 540tttgtgaagc tttactcaca caggagaaaa acagatcctc atcttgcttt gcccctgta 599324599DNAHomo sapiens 324atatatctta agccattttt aggaaacagg aggtttagtc acgtgctcaa caaaagcaca 60acaaatgggg agcatttaat ggtgtaaggg ctgtgaggtg tagctgctga aactgtagct 120aggagctgcc ttgctgcctt cttgcaggca gattggccag atgagccagg ctaaaataca 180attaatatct accattgtgg tttaatatga aatatggata cctggtcttt gtctcagttc 240ttgtcataga gttccccaaa cctttagaac ttcctgagtg gtaggaatat ctcattagts 300ataatgagcc cctttgattc gataactcct gagtttatgc taatgaggtt acttaatgtg 360gggccctaga tattcttagg atggggctag ttcccggaaa gaccaggtca tttgaggatt 420agagggttgg aacttttagc tctacccact gatctctggg tggggaaggt gctggagatc 480aagctgccta aaaactcttg aacaacaaga tttgaggagc ttccagtaaa tgcgtccaca 540agctgggagg gcactgcacc ccagtttcac tgggacagaa gctcttgcac ttggaatct 599325599DNAHomo sapiens 325gtataggtga aggtcaagta ctgcgaggct aaggtgtagc actactcatc ttcctgagca 60caaaagtcac cagcaccttg ggctgggtgt cagagagctc acagaatgtg gataaccaac 120caggcagatg ttggtaacag caaccaggag ggcacagcac aaacctgagc aggtctttta 180tgtatgtgaa ggtgaaggag ttatgattta gaaatggcag tgggaagcaa ggagaatgct 240gagagcctgc tcagctcttg tcttccagga tcatggatag tgcaaaatga gtagccttcm 300tttgagagac agagccatga ggctagtgga gtgctcagaa agaagccaga tctctatcaa 360ggaaaggaga tggagagaac aaccagggat gtacttgaaa gaggagagtt gcatgtctac 420aatggaatat gtgttgcaga ggactcagtc acagagaaga caactgcagg agggtgagct 480ggagggctct gcaggggcag gagcacagta gggcattaga atgggagttt tagatgagaa 540ggattacatt tgcagtgctg gaggaagatc atctcaaggt tcacaaaatc aagctttaa 599326599DNAHomo sapiens 326gggctgctaa acttaacaat gcaagatatt cctttttaaa atagtagtgg cttagtgata 60gaaacagaac taagtgtata tttttacaat ataatgtgtt gagtaaagaa tatttaatag 120tcactatatt atgagttgaa aataaagcta cagaaaggga acctaacctg gccagcagat 180ttttaacaag gaaatctaaa catttgcata aagcataata gacttaaaaa aattatgata 240aagatgttat cacaggactt gtttgtttct ttatacttac tattcactat tcttacttcs 300tgaagatgga tggttatacc ttcagcaatg tacttaaatc cttctaacat cttatgtgaa 360gttatagttc ttatctagaa ctaactgaaa aagaaagcaa agcttcttga aaataaactc 420cttttttgtg tgctaaaata ttattttaat gcttcaaaag aaatgaaagc ttttatgaga 480agaatgttga cctctgtcca gaccaaacaa gatgaagaag tcttatttta acatttgaga 540aatatcagtt gggcatcaga taacattcct gaaagggact gaaaacaatg cagtatact 599327599DNAHomo sapiens 327ccagagcccc tgtaagcccc tctgaggctc caggagggga ggctcagcac caacatccag 60cagggcttga agctgtgcca gggcctgtgg cactctccct ctctatgaac tctcccctct 120ctgtgaactc cgccgtcctg ctgggtggtt tcttgctgct gcactggggc cttcagctca 180ctattatgct gagctgaaca ccctaggctc acggagaggc ctcctcttct gggaagcctt 240ctctaacctg cgaattggtc atctgcacat ttagtgagcc tatctatcaa tgagggctay 300tcactggcta cttactcaat gctgctgaaa cttcagggag ctagagtgcc agtgtctaaa 360aaagacacaa aacacataca tcattaacat catgttccta catccagctc caacaactgc 420tccaacaggt tcggagggga cagacaaaac cacccagagg gaaaatccaa ggggatgaga 480aatgagaaag gctcccctac accctatgac ctaaggctgt atgctttaac taaatctggc 540cgacagcctt gcctcataat acctgagaaa atattccagg tcaacaagtc accctgaac 599328599DNAHomo sapiens 328attattcatt aactcattca ataaaaattt tcctgagaac ctccctctgc atccagaatt 60gtgtcagaaa ttgaggaaga cgcaaagatc taaatccacc acaaagtttg gtactacatg 120tatgtacttt aacttgaaca aattaaaaaa atccaaacag gacacctgag gttccagtct 180tcagtggaaa aaatatgact agtaattcaa taccagtgta cttacaaaca cctttatgta 240tgatttgggg cagagggcag gcttagagac atttagcagg catgggacta gatgcagtgk 300tcagcaggcc aggtttgggt tgaaagacaa caggccatag aaaaagccat tagaatgttg 360atgcagcaac ttccagcagt agctgttcac ctgggaacaa gcagctctga acttcaagtc 420aagcattcca gtagcccaaa acaaagatct aagcattaat ctggcctccc tgcaaagact 480gacaacatat aagtaggtga aagggcacat aactcctttg aaactgctaa gacagctaaa 540taaatagtct aaatattaaa aaacaaaagg ctgacattgg cagcaagata aggtcagac 599329599DNAHomo sapiens 329gttttagaac tggtttactc agaagtaatg cactcagaag ctgtccatcc cacagggccc 60tgggccttcc aagggggcac agacaggctt gaggcagggc attgggaatt gaaggcaggg 120gctgcaggca gaacagccat acttttagcc acttagggtg tatttcattt actagactta 180aattatccta ctttaatgaa agttctgtgg ccaaaatgtt tagaaaggtt tgaaaaacac 240tatattagcc cttctgtaga ctaaagtggt cctaaacaca ctcacaaatt ttgtttccas 300tttccctggg aatagacctt ttggaactta aatgctttcc tcaggtaatc attgtgtcac 360atggcaagaa ggttcttaag ctgacccatg acacagctga cccagaaaaa tacactgcat 420ttctactctg aacttggggt atctcctttt cacatcaagg gcattcttct gagccgcagc 480tgtcacttag ctccgtgaga aggaatctcc catgtccact caggtggcct ctaagcatag 540cacaatcctc ccccagttcc cccctcccct ccccactccc ctctccccag gcaacctca 599330599DNAHomo sapiens 330caggcctgga taaagttctt gttgcagaac ttgctactgc acaaactttt gttccagggt 60tagatcagga aggatagtaa ggaaaacaga gctgtctcca aaaggtggga tagaaagctg 120tcctttagaa gttaaattat aaatcaagcc aatcagagca aagatacaaa atgtctccat 180aaagaaaaat aagggctgag agaccttact gagtaatgtt actcagtaac gccttgctct 240atctaaaaat gtccatctga ggagaggcgg cctgggtacc ataatacaga gagcctcaty 300gacacaaaca gatggtgtcc accaggcccc atctagggag aagggctggc caggccagca 360gggatgagtg aacagtactt cctataggtt ttgacctgtg ttgtggaaag agacatccca 420cattgcccga gcctgatatc atcaaacatt taagtcagac aattcactct tccgattctg 480attttaggct cactaagcca ccttctgact atggggctcc aaactgcatg gctacaagaa 540gagaatgtgt tcatcaggtg gcctcgagtc cagtgttccc gacagtcttg cttctaaca 599331599DNAHomo sapiens 331cagtacttcc tataggtttt gacctgtgtt gtggaaagag acatcccaca ttgcccgagc 60ctgatatcat caaacattta agtcagacaa ttcactcttc cgattctgat tttaggctca 120ctaagccacc ttctgactat ggggctccaa actgcatggc tacaagaaga gaatgtgttc 180atcaggtggc ctcgagtcca gtgttcccga cagtcttgct tctaacagga atggataagc 240ttcaggtttt ggggtcagat ggccttgatt caaaccctgc cactaacata catagtaacy 300atgtgacctt gggatttcct tcatcttttt ttctcccaaa tgaaaaataa atagattata 360atataccaca tgatagtagg gagaaataat gaggtaataa tgcatgtaat gcatttagca 420tagcacttct ctagcaaata gtgaatgaaa tcagtcagtt gtcattctga ctttatgcaa 480cagtgctaat cgactctggt acactggaag tcagatgaga tttttggccc cacaaagtca 540aggaccaaac ctggaccttg ggaagttgcc aagatgaaaa acatcaggcc ggccttgac 599332599DNAHomo sapiens 332tgcttctaac aggaatggat aagcttcagg ttttggggtc agatggcctt gattcaaacc 60ctgccactaa catacatagt aactatgtga ccttgggatt tccttcatct ttttttctcc 120caaatgaaaa ataaatagat tataatatac cacatgatag tagggagaaa taatgaggta 180ataatgcatg taatgcattt agcatagcac ttctctagca aatagtgaat gaaatcagtc 240agttgtcatt ctgactttat gcaacagtgc taatcgactc tggtacactg gaagtcagay 300gagatttttg gccccacaaa gtcaaggacc aaacctggac cttgggaagt tgccaagatg 360aaaaacatca ggccggcctt gacctcctga tgctctctgt tcacatgtgt gatgtctata 420aaaggtaacc aggatttggc ttatctgctt acatctcttc ctgtcttttc ctgatcttca 480tcttcccaaa catagttttt atgcagaagc agatttaact ctactttgct atcttggagt 540caagaattgt cctataagga ggaagaggct ccaaggcttg ccttttttgt tttttcttt 599333599DNAHomo sapiens 333gcagaaactg tttgtggccc agcaggtgtt ggcactgggt gagtgcttct ggctcttgtc 60ccacgacggg catccaggtc ttccagcggc ctgaggatat aggaggggct tcaggcggat 120gattggggcc gttgcttatg ttttttcctt gtttggcctg caggtggcag cacaccctgg 180gccccccact ccccgccgca agtcctgagg atggccagca gagaaacaag aaaatggact 240ccctggctgc tggagagttg aatgccagcc accagccatg ggtgagtgga gagcctgacy 300ggagtttttc tctaatttgt tctgcattat ttgtgttttg atatatgaat tggtgtaaat 360cacatgtgtt caattttgag gccatttgtt gatttttgcg gtttatttac aaaaacaaca 420aacaatagca gtgaaaccag aattattcct gcaatgtttc agagagtatg agggacaagg 480gcgcatcctc tgcattgtaa gtgtgacttc ccttcccttc tgcatcttgg gcctgtctcc 540tttgccatcc aggtaggagg tatccaccca gaatagttca acaagtgtgt ggcaagctg 599334599DNAHomo sapiens 334tttctgtttt gatcacattt gttagctttg tgcttagaat aaaataattt cagtttcata 60aatgggaata agcccttatg tcaagggcca ctacatcact tcttggcatt ccagtgaggg 120gtctagtgaa gagcttccct gaatttcagt acctttcaag gcctctcttg aaagaatgtg 180gaattaattt gggtggaggc ttgtgcatgg acttttttct gagtgtattt ggccagtggg 240ccaatgggga agcagaggca tggacagaga gaggaatgcg gcagaaggag aagctggggy 300tgcaggatgc catttgctgt ttgtatggct tcccatggcc cactgtagtg gctagagggc 360actgccagga atccttcatg tggctgttgc ttgctgttgg ggaacatgat tcagagctgt 420gtagctccat gtccagttcc actctgcatc tcactcacaa agctctagcg ttgggctgct 480gggttttggt gaaagcaggt gctatgaata tattgaagga caaatcagtc cctaagggac 540ttcgatagac gcagtcctaa aaacatttcc gggctggttt ctttttttta aacaccagt 599335599DNAHomo sapiens 335cctttgttct gtttggggaa tcaaaactgt gttcctccct gtaacaccaa atactagagc 60cccaggggca ggtcccatca tgaatgccca gtagtcagtg ccaaaaaaac ccaagtcagg 120gaagactatg agacctgcct ctggggctct agtaaattca gatgagagaa aagaaggtgg 180gtggtgtttc caggcacaca ggtgtgagaa ggactaggga gcacttaggt ccaacttgaa 240cattatttgg aggagtgcag agagattgta ttggacaggt tggttaacca gatttcagts 300gtggtgagag tttgactatc aagccaagga gtttgaattt gataccataa ggaataggaa 360gtggccgggc gcggtggctc acgcctgtaa tcccagcact ttgggaggcc gaggcgggtg 420gatcacgagg tcaggagatg gagaccatcg tggctaacat ggtgaaaccc cttctctact 480aaaaatacaa aaaattagcc aggcatggtg gcgtgtgcct gtagtcccag ctactcagga 540ggctgaggca ggagaatggc gtgaacctgg gaggtggagc ttgcagtgag ccaagattg 599336599DNAHomo sapiens 336tgtttataca ccctgtcctg gcctgagcct cctgaaggct ggcacattca gcacagaccc 60ctctcactcc tacttcccac ccaccgccct tctgtgggtc acctgcccac tactcaagat 120agcactcttg gcttcttctg gaacttctgt cttcaccacc ctgtgttcgg ctctattcca 180actcatctct aatttctctt taccgagacc aggccgctga cagccctctc aacgattcta 240ggagattttt gttatttctt ctctggaaat acaatataaa gaatttttat atggttttcy 300aagtagatat gaagcttttt aaattaaaat tttgtgttct gataagagaa atgaaccatc 360ttcatcattt taagaagtag aaaatatatt atagaaaagc accaaagaaa ataaaaacaa 420catagaaagt aaaaagtgaa agccctacca ccttcaagag gtgacctctg tcaacagttg 480atatatctct ttccagactt atttatacaa acaaatgtgg atctttataa atatacgtat 540gcacagcttt gttcatgaaa atgggagcat gctatatact ttgtacagca actggcttt 599337599DNAHomo sapiens 337ggtgtggatg gacaggtgga gtgggccaga gcctgagacc tttggctact gtctgcggag 60tttaggccta attctgtaga cttaatttag ggcctcaata gatggacata gtgtaatgac 120ctgttctcta

gggaagtcct actccagggt ttataacacc ctctacctga agcttaaagc 180tgtacacaca ggcaggtgat aagttcatac tgagtttggt cctacagaga caagccctgc 240actgtccccc acagcatacc tgccagggga gacacagttt acactgatag actgaagcar 300ttgaagcaag gcactatttt aaatgtgcaa catcaggatt atttgtagcc atgcatgcag 360tggggatggc aagtggaaga ggaatcagtc aatctgacca ttcaggcaaa agcagcagtt 420ttggtctcaa taaagagata attggtctgt ttgtttgttt gtttgttttt tctcatatca 480taggtccctt ccagattccc aggggcaagg atttatacca catccccagt ccatttttgt 540cactagggaa gcacctagat ccaggtagtt tcctccaagt ggtgtctctt tggctaaga 599338599DNAHomo sapiens 338tcttgtcttt aactgccctg aagcttcatg gaggagttgg acaagtacac acacaatgtg 60ctgcatacta caccagaggt atgtctaggg tgtggtagta gcagtgtgga ggtaaactag 120ttctgccaaa aagaggagac tacaaagcat ggggcgtggt ggaagtagcc ctccagggct 180ttggactcta atgtttctca aacagtagag tgttaactgt attaagttgt atttagtccc 240tacaacaaac ctgtgagata ggtgtcatcc atttcacata tgagcagctg aggctcagam 300aggatcatgc attggcctgg cctggtattt atagagcccc tgttgaatgc taaggggcgc 360aaatctaagt tccttcctcg tagctcacat tccacaggtg aagtcacttg cccaagacga 420ggctggaatg tcagagcctg gattcaaacc ctcatctggt ggcctcccac cttaccctag 480aactcactag ccctcaggac atcctcttac ggggagcata gactgtccct gccagcccct 540gtggggaatt tgaggattta gggaaaaggc tgggtcaggg ataggacagg ccctgctac 599339599DNAHomo sapiens 339gtgctgcata ctacaccaga ggtatgtcta gggtgtggta gtagcagtgt ggaggtaaac 60tagttctgcc aaaaagagga gactacaaag catggggcgt ggtggaagta gccctccagg 120gctttggact ctaatgtttc tcaaacagta gagtgttaac tgtattaagt tgtatttagt 180ccctacaaca aacctgtgag ataggtgtca tccatttcac atatgagcag ctgaggctca 240gaaaggatca tgcattggcc tggcctggta tttatagagc ccctgttgaa tgctaagggs 300cgcaaatcta agttccttcc tcgtagctca cattccacag gtgaagtcac ttgcccaaga 360cgaggctgga atgtcagagc ctggattcaa accctcatct ggtggcctcc caccttaccc 420tagaactcac tagccctcag gacatcctct tacggggagc atagactgtc cctgccagcc 480cctgtgggga atttgaggat ttagggaaaa ggctgggtca gggataggac aggccctgct 540actcctatgg aaccttctgt ttcctgagca ttccctggca gcccctcccc aaagagaga 599340599DNAHomo sapiens 340tgacttctgt acttactgga gtgatttgag aaggaaaata agcatgtaaa tcaagggaag 60ccaggatcac tcactctcct ggtcccagtc agccctcgtt tttgtttaat ttgtgtattt 120cgaagcacac atatctctag ggaagaaaat gaaatcaaga actcctcctg gccaccggtt 180tcctgaagca tgaaaaggaa gcatttcata aatgctttgt aaagaagaca acaggaaggg 240gtagtgtcac tggctggcaa gagctgctgt tgtggtattt cacagacaag ggaggtgacr 300tggcacatgg gggctgaggt cccagccaga ggccacacag gcacaggcct cagagcccag 360gcctccctct ggcctgtaga ccctcagccc tactggacag gaggaaaagg cctaggggac 420attgccccca tttcacagag aggaggctga agccagtgaa gcagagagtt gcagcttcag 480tggggagaca ctgttatgcc ccgcctgtct tattcatgct tcttttacct gtagggattt 540ttttttacat ggctaccctt gagtgataga gccttcatca gcttagcttg tcctcttgc 599341599DNAHomo sapiens 341tacagtcatt tctcctgttt tcaaacttta tatgatgtaa atggaatcag gcagtatata 60tcctcttgtt gtgtttgtga gatgattcat ccaagttgtt acttagagct gcagtttatt 120cactcttctt gctatagagt attccactct atggatattc ctcgatttat ccattctact 180gtgatgcatt tttggatatt cgagttgtta tttataattc ggaactattc tgactattgc 240aatgacatgc tagtgtgtat ttttggagta catgtatatc cattgctggg gaagcatggr 300tatgagtatg ttcagcttta gtaccttatg ccaaataatg ttcccaggtg gctgtaccca 360tttacactcc ctccagcaat gtatgagagt tctggttgct tcacattttt gccaaccata 420gatattttct atctttttca tgttagccat tctggcaggt atgtagtggt atcacagtgt 480ggtttgaatt tgcatttccc tgatgactaa tacagctgag caacctttca tatgtttgtt 540agccatttag atcttctctt tgcaaagtgc ctgttggaat atttggacat gagtatttt 599342599DNAHomo sapiens 342aatgacatcg tgtcttgatt gcatccccat tgcatcatct gggctcatct catccccacc 60tctggactgt aacatcatcc cagggactgc cggacactca tctgtgctcc cccacagaga 120gtataatgcc atttggtaat tcagtacagc ctcttccaac ttgagaaaga agatgcattt 180ccttccctca gtcttgagct gtgcaggtgt cacgctgagc tgccctgtgt gggctccatg 240ttggcacaca tcggttgcaa ggggctctgt gtagtgagtc tggagttgga ccactggccr 300ggcgctggga tgctagtgcc tggactgagt gtgcacagag gcccctcagg cagagccaca 360gtgggcgctg aacctcctgg tgaagttcac cgcagtaact agagctcagt gggaggggct 420ggcctatcag cacctgtcct gtgtgctttt tgaaaagagc agggtctacc ttctgtcaac 480tgaagtcctg ccagctgcat ggcatgagat gagggacaaa gtggcacgtg aacaaagttg 540acattttgga ggctgttagg ctcagagcca accctgggct ccatgtagtg ccatgactc 599343599DNAHomo sapiens 343ctgtaacatc atcccaggga ctgccggaca ctcatctgtg ctcccccaca gagagtataa 60tgccatttgg taattcagta cagcctcttc caacttgaga aagaagatgc atttccttcc 120ctcagtcttg agctgtgcag gtgtcacgct gagctgccct gtgtgggctc catgttggca 180cacatcggtt gcaaggggct ctgtgtagtg agtctggagt tggaccactg gccaggcgct 240gggatgctag tgcctggact gagtgtgcac agaggcccct caggcagagc cacagtgggy 300gctgaacctc ctggtgaagt tcaccgcagt aactagagct cagtgggagg ggctggccta 360tcagcacctg tcctgtgtgc tttttgaaaa gagcagggtc taccttctgt caactgaagt 420cctgccagct gcatggcatg agatgaggga caaagtggca cgtgaacaaa gttgacattt 480tggaggctgt taggctcaga gccaaccctg ggctccatgt agtgccatga ctcatggatt 540caggcccatc ttggaaattg ctctgggcgt agagctctca tttctgatag tccaagtgc 599344599DNAHomo sapiens 344ttggaccact ggccaggcgc tgggatgcta gtgcctggac tgagtgtgca cagaggcccc 60tcaggcagag ccacagtggg cgctgaacct cctggtgaag ttcaccgcag taactagagc 120tcagtgggag gggctggcct atcagcacct gtcctgtgtg ctttttgaaa agagcagggt 180ctaccttctg tcaactgaag tcctgccagc tgcatggcat gagatgaggg acaaagtggc 240acgtgaacaa agttgacatt ttggaggctg ttaggctcag agccaaccct gggctccatk 300tagtgccatg actcatggat tcaggcccat cttggaaatt gctctgggcg tagagctctc 360atttctgata gtccaagtgc agatattggg gttcctctaa ttggcccaaa tggtggcctg 420caccaaccag cgaccagagt gctgtctgaa tctagaataa caggaagaac acgcctccag 480cagtgtagga gagttcccca tgcagtgtgc ttcccattct taccagcagt tggtatcttc 540tgtctttttc acactggcca tctgagtctc ataaggagac tcctctcctt ccactgagc 599345599DNAHomo sapiens 345ctgtataatg cttcctgcca tcctgccttc cccgtggagt acagccatgc tgtctgctgc 60ttacagccaa gattctggaa agaaatgtct cctttttcct cgtcatcaac cactcattta 120ttcagcaagt gtttctttta cacttgcctg tgctgggcat ggcagcaatg cagcagtgaa 180caaaaccatc agccctgctc tcatgcagct tataatcaag tagagagaca gacataaatg 240attaatagat gctcctgtaa tggtggttgt gaggtgtgct gccacagccc agccacacay 300gccagttccc ttctctgcac atgtacatgt ctgctcatcc ttcccacctg aactcatgtg 360ccacctcact tatgcccctt cccaatgccg cacccacaca acagggtgtc cctctgtgcc 420cacagcagcc cttgggtata actgttcccc acagaggctg aaccccaagg gcagagtcca 480ggccacactc accacggaga cccctgcctg gcacagagcc cagcccagca gagatgctca 540gaagatgaat gaaagtccct gctgagattg atccaatctg tttgtgaaca tctctgggg 599346599DNAHomo sapiens 346ctgctctcat gcagcttata atcaagtaga gagacagaca taaatgatta atagatgctc 60ctgtaatggt ggttgtgagg tgtgctgcca cagcccagcc acacacgcca gttcccttct 120ctgcacatgt acatgtctgc tcatccttcc cacctgaact catgtgccac ctcacttatg 180ccccttccca atgccgcacc cacacaacag ggtgtccctc tgtgcccaca gcagcccttg 240ggtataactg ttccccacag aggctgaacc ccaagggcag agtccaggcc acactcaccw 300cggagacccc tgcctggcac agagcccagc ccagcagaga tgctcagaag atgaatgaaa 360gtccctgctg agattgatcc aatctgtttg tgaacatctc tggggtccaa gaattcacgg 420ctttcttttt ctttagagag ccttttgttt ctttttgcca ttatatacta tatttgggtt 480agggcacaac aatgtgaata tacttaatac tgaactctac acttgaaaat ggttaagatg 540gtaaagtttt aagttatatg tattttgcca caatttttta aaatgcagag cataggtac 599347599DNAHomo sapiens 347ttattgcaac tttgattaat gattgatcaa aaactgatac tagaaacact gaagaacaaa 60tttgctgtag acattaggaa aggtctacat ctggcaggcc tggagacctg cccaccctct 120ccccccacgg tcaaaccagg gcaaaggtac attggaagac ccaaccccta cacactctta 180cacgtgcact cgcacacaca cactgagggg aaagaaatat ttaattgtcc ttaaatcctc 240ttggattagg ctataaattg caaataaatg gagcaacaga cagagcaaaa gcacataagk 300tcctttaata gaatttctct atcttattct gtttctatga atgcctgtta caaattagca 360gcttaaaggg aaacctggag tgtgggaaag agcgaccctt gtgtgaagtc cacagccggg 420gtttcctaca gacctcaggt cccagagaac atctaagatg cctccaacac cagatggagg 480agggcaggag atgctgcaca gagaagcagc acttcccgag catctgtggc aggaagtgac 540ttggagagga tgaggccgtg cctcaggtgt gctctagctg ttctgatggt ctctgaggc 599348599DNAHomo sapiens 348gttctgatgg tctctgaggc cacgactgcc atggtgaggt ccacagcctg catcagaatc 60accaaagggc ccaaacgtac ggcctcagag cctggagagc caggaatcgg cattgcaaca 120actccctgct cagtgggttc taccagtcca gtacctgccc tctgagggtg cccagggagc 180agggtgcttg ctggctggaa cactttttcc tgcccctcag ctcctctgtg atgccctgag 240gcacgggcac tggaaagctg gcagagctgc ttctaaattg aaactggaaa atgaaactgk 300aaatcacagt ttcattttcc agtttcactc gctcccccta ctgttggggt ttcttttcca 360caaggagagt cccccaggga gaaagaagca ggagtgggag tgggggagca tgttggggga 420aggcagtgag ggtgtcctgt ctgcagcagg gcatggaggg gccccagcgc tgcacttgct 480tcctttaagc ctggcctgct tgctgtcagc cccgggggtg gtttcctctc taggaaaagc 540taatgtcatg cttatgctga aaaactcttt tcagaggtac tttaggaggg gcctggctc 599349599DNAHomo sapiens 349accatcacac ccagccaatt tttgtgtttt tagtagagac ggggtttctc catgttgctc 60aggctagtct cgaactccca acctcaggtg atccacccac ctcagcctcc caaagtgctg 120ggattacagg catgagccac cgtgccgggc tgacagtggt ttttaaaggg ggagggcaga 180tgaaggacgt tggtggacca tcctctggga ggagatgtgg actgaggaag caacgctgac 240ctcaggcccc acaccaccct ttcacctcag cctcactttc tcatcagtaa atggaactcr 300ttcttgtgta tgtgccatgg aggcaatgta gcagaagaga atagggcaga ctttggaact 360cagccatctg ggagaaaatc ctagttatgt gatgaccttg agccaatgac tgaatttctc 420tgtctcattt tctcttctgt aaaatgggga caattacagt gaattctgtg aattcattca 480tgtccctgac acatggtgtg agctcagtca ttacctttgc gagggttgca aggatgtaat 540gagatggcag atgtgagcac agctcccaga cccgaaggtg ctgtatgaat gggagggag 599350599DNAHomo sapiens 350ttgttttttg tttttttttt gagatggagt ctcgctttgt cacccaggct ggagtgcagt 60ggcgcgatct cagctcactg caagctctgc ctcccgggtt cacgccattc tcttgcctca 120gcctcctgag tagctgggac tacaggcgcc tgccaccacg cctggctaat tttttgtatt 180tttaatagag atgggatttc accgtgttag ccaggatggt ttcaatctcc caacctcatg 240atccaccggc ctcggcctcc caaagtgctg ggattacagg tgtgagccac cgcgcccagy 300gactagtctt taaaaaaatg aataatataa atttttttaa aagatgaaaa catatatata 360ccctgtaacc caagagtccc actcctcaga ctcttctcaa accacactct tacccatgtg 420caccagaata cccacacagc accagaaaat gtccaaatga ccatcaaaag tggagagtac 480aaataaattg tgcagtgttc ctggagtgaa atgaactaca gcgacttgca ataactgtaa 540tattgtcata ttggataata atactgtaat aacaaatgac tcatcaatga ataaaacct 599351599DNAHomo sapiens 351tgtgttgttt taagccccta agtttatgtt agtttattag agcagcaaca ggaagctgat 60ccactgggaa accatctggg atatgcagct gcccaaaatc cctgctcgtg gttagattca 120gccttacgag gctccacagc ccctctgcga aagactccat tccctcttgg agaagctcag 180actctagagc cctgggcaag gaatgggcct tcatggcatg ggggcgatca agaaggatgc 240cccccaggac agtgactctg ctggacttct ctacagaaaa cagtatatcc ctcagtggcr 300tgagaagatc caatagggtc accacactcc acaactgcag gggacactgt tcacatttta 360gtctatgcag cctctggtgg ccaaagatta aatgagaaca cctttgctgt gtgacctgaa 420gttcatggtc agtaaattgt agctattgtt atgcacgact tagggggaag caggggtcac 480tgcagagcag cagtggtttt atagagattt gctttatgat tatttgttaa actgaacata 540tattctatgt atttttctgc ataattattg tttcacaatt tttaaaaagc atatacaca 599352599DNAHomo sapiens 352ctcagactct agagccctgg gcaaggaatg ggccttcatg gcatgggggc gatcaagaag 60gatgcccccc aggacagtga ctctgctgga cttctctaca gaaaacagta tatccctcag 120tggcatgaga agatccaata gggtcaccac actccacaac tgcaggggac actgttcaca 180ttttagtcta tgcagcctct ggtggccaaa gattaaatga gaacaccttt gctgtgtgac 240ctgaagttca tggtcagtaa attgtagcta ttgttatgca cgacttaggg ggaagcaggk 300gtcactgcag agcagcagtg gttttataga gatttgcttt atgattattt gttaaactga 360acatatattc tatgtatttt tctgcataat tattgtttca caatttttaa aaagcatata 420cacacatgaa tcttctctag ccccgaacag cacagtgaat ggatagggca gcagatgagc 480tctgccccac gccggccctg tttcagaaca gcactccaga gtgccgcact gcttgctgaa 540ccacagctgt tactgcagat tgaggagcct cagagggaac agaagataaa gatcattat 599353599DNAHomo sapiens 353caccacactc cacaactgca ggggacactg ttcacatttt agtctatgca gcctctggtg 60gccaaagatt aaatgagaac acctttgctg tgtgacctga agttcatggt cagtaaattg 120tagctattgt tatgcacgac ttagggggaa gcaggggtca ctgcagagca gcagtggttt 180tatagagatt tgctttatga ttatttgtta aactgaacat atattctatg tatttttctg 240cataattatt gtttcacaat ttttaaaaag catatacaca catgaatctt ctctagcccy 300gaacagcaca gtgaatggat agggcagcag atgagctctg ccccacgccg gccctgtttc 360agaacagcac tccagagtgc cgcactgctt gctgaaccac agctgttact gcagattgag 420gagcctcaga gggaacagaa gataaagatc attatggaat ttaggattgc aggacattct 480ttgacatttc ataacagcca ggggagatca actgtggtca ggggacaggg gcaggaagaa 540accatggcca aggcctgtct ggcaggactt gaaggggcag agggaccctt gcaaatgac 599354599DNAHomo sapiens 354agaagctgag acaggagcct agaggatgga cagtaaggag tcgaaggctc aggatgaggc 60tttcctgact ttctccccta gaggactgat gttctctact ggtacagacc ttgttttatt 120catccttatg tccctaacct ggaatgggcc cagggtgaca gttataataa gtgtttgtca 180agtgagcaag tgtgtggagt gtgcattgta gagagtaagg tctctacagg atcctgctgg 240agaggcagcc cactgggctc accacttctc cagaggaggg actggtccct tgccagacar 300ccctgccagc tggagcaggc ttcctcaggg gtgcctggag ctgttgacca tggctgttgc 360cctctggccc ctcttgggaa gagcaacctg tcaggtgtta aagacggtct tcatttctct 420tctccaagta aacatgacta gtttccatct caccatcttc tggccctcag cagactggtt 480atccagtctg gagaggcaac agtagtatcc agatgtgatc cgaacagaca gaacgatgga 540tgcagacgga aaattcaggt ttgtgtgctt cggcagtcag tatatgcaag tcgtaatgg 599355599DNAHomo sapiens 355ctggacttgg agggaactga ctagggatca cctcccagct ctgccatgga cccactgtgt 60gaccatgggc aagttacttg acctctctga gcctcagtta tcttatcagt gaaactgggt 120taataatata tctctcagtg gcacaggagg atcacatagg gtcaccacac tccacaactc 180caggagatgc tgttaacatt ttagtctatg gatcctctgg tggcctaaga tttaaatgag 240agcacttttg ctatgtgacc tgaagttaat gtcaataagt tatagctatt gttatgtacr 300atgtaagcag gggtcactgc aggccagaag gctgacacaa tttggccagg ctttgttctt 360caaggaaggg cagggctctg agaagtgcag accgtgatgc aggtgaaggc caggaggcag 420ggactcccag ggcaggtctg gaaggagcga ggctggtgac ggaagtggtc agcaacctca 480aggcatgagt aaggcgcttg cccttctctc caggcacaga ggagtcactg gaagctgggc 540aaagagctgg gatggatgag accaaggcga atactttact tattaagctg caaaggacc 599356599DNAHomo sapiens 356tcttcattta agaacccttg tgattacact gggcccacac caataatcca gggtaatctc 60tctatttgca agtgagctgg ttagcaacct taattccatc tgcagtttta attcctcttt 120gccatgtagc aacatattca taggctcatg cattaggacg tggacctctt tattccactg 180tggaccaata ctctgccttc cacacctagc ctctcttctg agttttccaa gggcccccca 240tcctcaggca tcctcaggca tagacagccg gctgggccag accacagtca ggatgttccy 300gccactatca gagaggtcct ttctacctaa gtcccctccc acctgcctgc tcctctttca 360gctcggtctg tcctggattc ctcttccttc atcctctgct cccagtctta ggtagagaag 420agctgagcag gaagtgccag ggggtgtgga gatggaggag ggggaaggta aggcctgagg 480caccagggct ctgggagccc agggagctga ggcctttcaa tccagacacc ctgcacttct 540ctggctctgg ggcctctggg gaccacacac tcagctccag ggctggaggg gtggccagc 599357599DNAHomo sapiens 357gtaggaaggg gtcagataag gtgggcattt ggggcctctg atcaggggct tgggccttat 60gcacagggtg aaatgggcca gtgtgcattt tacttatttt taaactttta agttttctgt 120ttttcatttt tttagatgga aaaatgttgt ccaggctggt ctcgaactct tgagctcaag 180catttatcct gcctcagcct cctgagtagt tgggattaca ggtgctcatc actgtgcctg 240gctcagtgtg cattttagaa agctcactgg ctgctgtttg cagactgggc tgcagtgggr 300caagtgtgga aataaggaga ccactgggga gactggagta ggagggatga actagagtgg 360tggtggtggc aatgatgaga atggggaatg aacccaggca gagtatagag gggaggacac 420acagagatga ataaaatgtg gtggctccga atgggagaaa atatttgcaa aacatatatc 480tagtaaaggg tatgtatcta gcatatgtaa agaatgctta caactcaata aggcaatgca 540tttttgtttg tttgtttgtt tgtttgtttt ttgagacaga gtctcactct gtagcccaa 599358599DNAHomo sapiens 358ctcaagctga ccactggagg gtgcacacac aggacagatc taaacagcac tataaaggct 60ttgaaaatgg aacaaacatt gaaactacaa tccacagaag gctggtcgga acttgtggcc 120caaatgcagc tgcattgatt gcctgctaaa atataaacat taacactctc cacaatgttc 180aaataatacc cagagtctca taaaatttaa aatgtccagg atacaaaacc aaagtatgat 240cttcctggcc tatgatagga aaaatctcat tttgcatggg aaaagacaat caaaagagam 300caatgatgag atgttggaat taagtaacaa agactttaaa gtactactat gaaaatgctc 360caagtaaacc ctcttggaat gaatggaaga tggacagtct cagcaaagaa ataggagata 420taaagaatag ggaagtaaaa gttttggaac ttaaaaatat aagggccagg catagtagtt 480catgctataa tcccaacact ttgagaggcc aaggcaggag gataacttga gcccaagagt 540tcgaagctag cctgggccac aaagtgagac cccgtctcta aaaaaaataa taagttagg 599359599DNAHomo sapiens 359ttccctattt tttgtttgca ggtggcgggg gctccctgga cctgggattc ccacgttctt 60cctcctaact tgctgcctcg tggccctaga cccctcttgt gtaacacaga catcagtcag 120gctctctcag gctcctaaga cctggacgac aggctcaagc tcctatttgc tcacgtgcaa 180gtggaaagct tttgccaggg tgtttgcaag ttcccttgtg catgactgtg catgactagc 240actgactctc tcctgataca gcatggttag atctgtgtgt ggctcatcag gacattcaam 300aagtaatgcc cctgttctgc accccacaga aggcagtcct ttccactgag tcccattcac 360acagccaagc tgaccatcac ccggatctgc ctgtggcaga agcaacttca aagtgagcgc 420tagtgctcct attcttgaag tcctgtggtc acgctacagt gatagaactt cttcttcttc 480accccctttc cattctgtct gcagctttgt gccatcttgc cagttccccc tctctcttca 540cccaattgca gtttatttct aatacacaga gcaatttctg tagccctttt gtaacaatt 599360599DNAHomo sapiens 360tttttaaaag atctctagct tttgtgtggg cacagattag gttgtaatgt tcgaccagag 60aaacaagtta ggatgctatt gctccatggt gagtgacatg gttatacagg gtgaatggtg 120cagggtgggc tggaggagaa gacagaatcc tacagtgcag ggcattgtag tgggcatctg 180atctctctct tctcccacct ctatgcagct gcttctctct cctcagaatc cagacccaaa 240ttttaccttc tgctgggaaa gccttccttc cctatttttt gtttgcaggt ggcgggggcy 300ccctggacct gggattccca cgttcttcct cctaacttgc tgcctcgtgg ccctagaccc 360ctcttgtgta acacagacat cagtcaggct ctctcaggct cctaagacct ggacgacagg 420ctcaagctcc tatttgctca cgtgcaagtg gaaagctttt gccagggtgt ttgcaagttc 480ccttgtgcat gactgtgcat gactagcact gactctctcc tgatacagca tggttagatc 540tgtgtgtggc tcatcaggac attcaaaaag taatgcccct gttctgcacc ccacagaag 599361599DNAHomo sapiens 361ggaaactgcc acactggcac cccctattcc tccacagtca tccctcactt gtctgttcat 60ttggttgttt

attcattcac tcagcaaata ctcacacagc tgcaatgtgc caggcactgt 120tctaagtatt ggtggcacag cagggagcag gacatagccc tgctctagca gcatcataca 180catttaggag ggtcagacaa caaacaaata aaacaactat aaattgtggt aagtgccttc 240agtgcaagta gtagaagcaa aacaacccag tgttaagatg ctaaagtcag gctacctggk 300tttaagttct gcttctactg ctacctgcca ttgggcaagt taattaatct ttctaggagt 360cagttttcct ttctatagat tggaagtgat catcaaacct actgaatagg attgattgaa 420gatttattct ttccaaaaat atttattgag caccactatg tgccaggcac catgccaggc 480actaaggatt aatagtgaag gtgacagaca aggttctgcc ctccaggaac atacatgata 540gcagaggaag agtcactgga caagcaaagg ccatgtcgga tgtgataagg gctagggac 599362599DNAHomo sapiens 362cttaaggtcc cagctcttgc caattggccg tctgcatgta gtgctctgta tcgctgtagt 60gctctgtatc tctgtgtgct ctgtatctct gagtttcagt aaatagtccc tctcctgttg 120cagttcctgt taccagtcgc caagggcttt gttttcccta cactctattc ttttataatg 180gtccctttat taaataaact gccttaagtt actcaatatg agtgtcccta ctgtttcctg 240ctggataagc ccactcccag gtcatatttt ctgtttttaa attagttttt caccggtctr 300tctgtctacc cctaggattt ctcaaccctg ccactactga cattttggat gggagaattc 360tgctgtggag ggctgttgtg tgtactgtag gatgtttagc agcatccgtg acctctaccc 420agtagatgcc agtagcatcc cctccttccc ctccaattct gacaacccca aattgccaaa 480tgttcccttg gggttgggga atcaccctct gttgggaact actgttataa ccccttgtca 540aaaccacact taattattaa ggcttgatat ctagcaagac aagttctccc atttgggtt 599363599DNAHomo sapiens 363ggcagggaag tgtaaggtgt gcaggagttt actaatatgt actgtcagaa tccagaatcg 60agtgcatcct gcagctgttt gtccagaaga atatagagtt gaatgggatt ggatttattg 120gtgtgggtat acttacgact cagaattaag ttttcgcaag aacaactgga gttagtccta 180atagtttgct ggagtggctc cttgaagcct gatcctgatg atggtgtaca gaatatgaag 240tggagacacc tgaacttcct cccatagtat tgaagaaaag agcagatagc tcagagaagy 300aggaatacta aaatggattt tttgtatctg gcctgagaac ctactatctg agtatgttcc 360tggaggacac agaatatact ccttttacta acacagcaac agatacacta gtgaagagaa 420gcaggcatca ttgcaaacat tggtggtgga tgtcccctgt aagctgggtt gaaggtgaaa 480gatgctgcca atgacatgga ctccctaata tcaataggca acatgagatc cctagaatgg 540cagagctcag gttggaagca cttaaacatt agaggcaagg gggacataat taccaccac 599364599DNAHomo sapiens 364tttcaccatc ttggccaggc tggtctcaaa ctcctgacct cgtgatccgc ccgcctcggc 60ctcccaaagt gctgggatta caggcatgag ccaccgtgcc cggcctcaag gagtctttta 120cctgcagcta ggagcctaaa gtaacaaaca acaggagttc tttggcagaa ctcctgggca 180aaagagagca aagctttaaa gttcagctac agagacggag gcaatgtgaa ctaccattta 240gattttttaa aatccacgtt attttaggga aatagaaaga aataaacaat tagtacttts 300atttttaaat aattactggt tggtaatttt ataatttaaa aaaagcactt tgattaatat 360tgaaaagtta cattggtggg taacatccat ccttttgccc taaaactttt atctctatta 420gtgggtaaca cattggcaac atgtctttaa aactgataac tgtggttttt actgtgtagt 480ccttaaggtc aaatgacttt tccatgaact gattctaatc aactgagcat gatgcctcgc 540aattttcatg atgactaaat gtaaattgat aacatctctt tttcttcttg actctattc 599365599DNAHomo sapiens 365gcttcagccc aggagttcaa ggctagcctg gacaatatag tgagacccac tgtctagaaa 60aaaaagtatc atgataaaaa tctttgtgta tgaatcattg tttgaattat ggtgtttata 120ctattcgtat gtgtaaagga catagaattt ggtctatagg tttgtttttg cacatataga 180agtgaaacaa caatacacac acacacacac acacacacac atatatatat agtttattcg 240tttttagtgg ggtcatgtgc ctctctagcc gctccctgac cccagttcca ctatgtttty 300gttacgtatt cttccaagct tttttctgct tataaaacca tgtctacgtg agcacataaa 360tgcattcaca catacatatt ttagcacatt aatataattt tatacttcta ttttattgtt 420tttaattagt aaattgtatt ccattgagtt tatatcctgt agtttattaa atgaccccct 480gttgattatt atttgtttct accttagtgt gattaaagat aactctgtaa ttatgaaaat 540atttatgaat tttcctctta gaaatgtaat agtatttagt acatttactg agtcctctc 599366599DNAHomo sapiens 366ccacaaatag gggggatcca gctcagaagc agagtgtcca cgccagggaa tagtgtgggg 60attcagagcc tgataatgat gagaaggggg cccacctgag ggttaagtcg gctaggggga 120agtcagatca tagagtagag acggcattct tgcaagaagc cacctggtat aaagtatcag 180actgagaaga gtgaccctct cagtgacaca gatctgggga gattcaggtc agagtacagt 240gggcatccct gcaagaggcc acctggtatc agagaagggc ggggaatgag gacatgatcy 300agcaccagaa gtcaaagtgt atacagaatg gaaaagcatc ccatgaggga gtcagaatga 360agagtcaaga gcctacgcag gataaggaag actggcatac agggatggag tcagcccata 420tgaggtgcta gggccctgat gcaacgatga gacattgatt acatacagga ggattgatta 480agtcaatata ttaagattat ggttgtataa gtacattctt gcactgctat aaaaaaaaaa 540cctgaaactg ggtaacttat aatgaaagga ggtttaattg gctcacagtt ccacatgct 599367599DNAHomo sapiens 367atacttcaga acaatttcta tcaaaaagaa taaaataaaa aataagaaaa acccttcttt 60ctccaaacaa tctagttgta aaaccattag gtggggcaga agaaggtgcg tgttcatgcc 120agctgaaggt taaggcacct ataactcagc ctagagtgga ataaatgagc ttgagtaggc 180tgagaagggt accctcatgg ggaaacagct tggcatagac agagtttcaa gagtccaatg 240gtatcagagt tccagcagga tgaaagagga atccacaaat aggggggatc cagctcagam 300gcagagtgtc cacgccaggg aatagtgtgg ggattcagag cctgataatg atgagaaggg 360ggcccacctg agggttaagt cggctagggg gaagtcagat catagagtag agacggcatt 420cttgcaagaa gccacctggt ataaagtatc agactgagaa gagtgaccct ctcagtgaca 480cagatctggg gagattcagg tcagagtaca gtgggcatcc ctgcaagagg ccacctggta 540tcagagaagg gcggggaatg aggacatgat ctagcaccag aagtcaaagt gtatacaga 599368599DNAHomo sapiens 368atccaaaatg aaagaaataa tagaattagt agataagaac cctaaaacct tattataact 60cttataaata tgctcataga tataaaggaa aacataagca taatgagaaa aatggaaaat 120aattttaaaa acccaaataa acggaataat ggtgttttgt atataatggt acaaataggt 180taaaagcaaa aggattgaaa aaatatactg tgccagctaa tgaaaagaaa gctgaagtga 240ccatattaat accagacaga agacatcaga actagggaaa atgaaacatt ttatgatgak 300aagaggtcaa tttaatgcaa ggacacaaaa attctaaatg taaaacttcc aaatatatga 360ggcagaaacc tatggaacag aatggagaaa tacacaaatc tgcaaggtca attggagatc 420tcaatacccc tctcagtaga gaaaagaagc agatgaaata tcagtaagta tatggaaaat 480tttaacaaca ctgttaacca aatcaacctg attgacattt ataggacatt ccattgaacg 540atagcagaat acactttatt ttcaagtgca tgtggaacat tctgtaagat agaccaaca 599369599DNAHomo sapiens 369atccggaaaa tccccaaata attgaaaaat taagcagcat acttctaaat attacatgga 60tcaaaaaagg aatcacaagg gaaattagaa aaaatacttt aaatgaatca aaaatatagc 120atgtaaaaat atgtggggtg cagctagata atgcttagag agatacggta gaaaagaaac 180caatcagtat aatttgccac attaacagaa taaaaaagaa atatcatatg aacaccaata 240gatacagaaa acgcatttca atttaatagt ctttcgtggt aaaaaccctc agcataactr 300atggaggaat attaattcct gaataattca gtccaaaatc cgttaggtgt ggctgagtga 360ggaaggcatc cacaaaaaca agctgtgaca gcctggtggg ggattggagc ccaagtaagg 420aatctatgag tttatactga tacaagaaaa tgggggggga aatggagaaa gagcaaagcc 480ccttatacta gaaccttaac taatataaaa ggaataatgg aactagaaaa ttactatagg 540cataccttag atattgcagg ttaagttcta atggatggcg gtcttgtcta cattgaaaa 599370599DNAHomo sapiens 370aattatggta tatattcata cagtgggata ttatgctgtc actaagatta cagttacaat 60gagtttttaa taacttgtaa aatgcctatg acataatggt aagtgaaaaa aattacattt 120atactgtcaa tcaggtaaat aaatatacgc acagaaagac aagtgaaaga aaatatgccc 180aatggttgct gctggatgag aggtagtaac tgatgacctt tctgcttttt aaattttttc 240tgttaaaaag aagcatccaa attgcaaaca cagttcaata acttaatgga ctacaaagty 300tatttaaggg ttacaaacct tgttgctgaa aaaatctcat caaacttttg cttcaaagcc 360tttccttcac ttaaaggcca attagaatct tcttgatgac agaaaatgac attatttagc 420acagccttgg aaaccccaag agaactgatc atttctcggt caatttctgc acacttagag 480ctcagactga ccttttcacc atgcctacag aaaatgaaaa tcaagaatat atgtaaaata 540accttcagtg tatctattct attgcttaat caattcatac tgtacttctt taaaagaat 599371599DNAHomo sapiens 371tcttttactt tctgaccttg tgtctgacgt acctgccgaa gtgtttctaa ggctttaatg 60tatctttgaa gatatgaaac aaaaatcaaa tttctggcaa agtaaattat ggtatatatt 120catacagtgg gatattatgc tgtcactaag attacagtta caatgagttt ttaataactt 180gtaaaatgcc tatgacataa tggtaagtga aaaaaattac atttatactg tcaatcaggt 240aaataaatat acgcacagaa agacaagtga aagaaaatat gcccaatggt tgctgctggr 300tgagaggtag taactgatga cctttctgct ttttaaattt tttctgttaa aaagaagcat 360ccaaattgca aacacagttc aataacttaa tggactacaa agtctattta agggttacaa 420accttgttgc tgaaaaaatc tcatcaaact tttgcttcaa agcctttcct tcacttaaag 480gccaattaga atcttcttga tgacagaaaa tgacattatt tagcacagcc ttggaaaccc 540caagagaact gatcatttct cggtcaattt ctgcacactt agagctcaga ctgaccttt 599372599DNAHomo sapiens 372ttaccattac atgtgcttgt catctctcca accaagatgc tcctcaagaa aataaaacgt 60ggagtggggc aagggggaaa gaagaaaaaa aaaggaaatc tgttctaata tcttggtaat 120taccacggga cccacacaga gttatcagga caactcatcc taaaatataa catagtcttc 180cactcttctg tctattgaac taagtctgaa atccattagc tttctataat ctgaccccga 240ttcatattgg tcatttactc cttttatatt gatttactta acccagactc ttcctctcay 300aatcctgttc tgattaagct tgtaaaggta aatatgcaca tacatacaag tgaatgtttg 360tatatacata tgtattgtat atatgcagtt aaaaaaagtt gcaggtaaaa tatactctgg 420aaggttagag atgagaaatg gaagactatc ttttactttt cacctaatat ccttttataa 480cttttttact aggggcacat attactttta aaagaaaagt caaaataaat acaaacattt 540ccaggtgcgg tggctcacgc ctgtaatccc tgcactttgg gaggccgagg cgggcagat 599373599DNAHomo sapiens 373agtgctcagt ttctttccat cagtgttttc actgcctctt ggtagcacaa acattatgat 60aatcatctgg gcttggatct ttcatgacat ctctacctgc ttcattcctt aaatccagcc 120agtcaccaga tcccctgaat tccttctttg acatctgtgt tttggttcta atctcagagc 180acaaaacata ggttctatcc ccagagtaca cacctagtaa aaggagctag gacaagcagg 240cagacaacaa taacaaaaac agccaagggt ttaaagctta ggtgccagtg tgaaatgagm 300taaaaaaaat agagcagctg ggctatcaag tatagaagga ccatgaactt gtgtgcagaa 360aaaaaaagtt agaaacatat tcctctagca attcccattt aaggcaagaa aggaaaacag 420atctaagtag gccaaaaaaa gaggacagga tatggtggga tggtaataaa gtagtttatg 480agagagtgag agttcccgaa gataaaggga atcagtaaaa atgggaaagg atgcattcta 540gtgcatggtt gaaaggacgt agtcttttct gggaaggtga tttgacccaa actttaatt 599374599DNAHomo sapiens 374tttggagatg taatagaaat ctcttatttc atgcttacct gtttaattgt tttaaaataa 60tttattgtca tgaaatggta tgttatattg ataaacttta gttcttacat acaaggagac 120ttcagaaagt tcatggaaaa atggaattaa aagataaaaa ttttaaataa actgtatttc 180tcaacataag ctccatcaag ttcaagactc ttctgagcag tgataccagc aatttagttc 240agtcctaaag aactgagggt cctgggaatt taaccatgtc agtgtagtct tttttacaty 300gctagcataa aaatgggtgc cctttaaaga tttttttaag attaagaaac tagaagacag 360gaggagccaa atcaggactg taaggtggat gcctaatgat ttcccatcga aactcttgca 420aatggccctt gtttgatgag aggaatgagc aggaacattg ttgtggtgga aaaggactct 480ctggtgaagc tttcctgggc atttttctgc taatgctttg gctagctttc tcagaacact 540ctcataataa gcagttgtta cctttcttcg gccctccaga aagtcagcaa gcaaaatgc 599375599DNAHomo sapiens 375gtatgtatat gtactacttt gagaaatttg tttcagataa atgtgtgtga ctgcacacat 60gcttcttcat catgactacc catcctgagt cacagtaaac atttggaaaa aagtaactaa 120tatgatgata ttttcattat cctagactcc cttgagcact tctcatcaag atcaccagtg 180acctaagtgc caagtacagt cttcatctta ctctacctct acgtagcacc aaacactgtt 240gaccttctcc ttgaagacta ttttcccaag gcacctagac accacagcta tctggctctm 300accctggttc cctgggcaca tcccagtttc cttcacttgc tccttttcct ttgcctgcta 360acattttaaa tgtttgtgct tcccaggaat ctaattgtaa ctccttccct ttgcataact 420ctctcaaggt gacatactaa tgactttgag tatcccttac atagcaacaa cttccaatct 480cctgaatttc aaactccaat attgtattcc ctcacagata cttccacaag aaacacagat 540taaacaccac caaagccaag tccttctact ttcctcaaaa atctgtgtgg aatttttga 599376599DNAHomo sapiens 376gtgcttaaaa aatgattcaa acagatgtgt taggtaagaa gggaggagcc aatggataca 60gaatgagaag aatattttga gaatgaggca ggaagaggaa tataagacct ggagaagttc 120attcagctca actgagagga gacggaagtc agaacacggt gcaaagggaa gaggagtatg 180acctatgctg cagtagaaat gttatctgga gtttggggaa ttatttatag ggattgagtc 240ctgtatgttg gggagatagg gctacattat attcaggtct agttgtaact ctgataggtr 300atgaggagcc aacctaaggg agttagtgaa agatgtattt taggaaaatt aatctaatat 360taatatattg actgaaacag gctgagaaaa gctcaggaag cagaaaaacc aggagagtga 420aagtgattgt cctggaaaac caaggaggag tttcaggaaa aggagaaaga aaggcctaag 480aagatgtggt ttgtggcagc caacttctaa gatggtccct agtaatctcg gcctcttggt 540atttatactc ttgtatagtc ccatctcatg ctgttgcatg attggtctat ataactgat 599377599DNAHomo sapiens 377acattatatt caggtctagt tgtaactctg ataggtgatg aggagccaac ctaagggagt 60tagtgaaaga tgtattttag gaaaattaat ctaatattaa tatattgact gaaacaggct 120gagaaaagct caggaagcag aaaaaccagg agagtgaaag tgattgtcct ggaaaaccaa 180ggaggagttt caggaaaagg agaaagaaag gcctaagaag atgtggtttg tggcagccaa 240cttctaagat ggtccctagt aatctcggcc tcttggtatt tatactcttg tatagtcccm 300tctcatgctg ttgcatgatt ggtctatata actgataaaa caggcagaag tgatagcatg 360gcctttccaa cattaggtta tttaaggtac tatggcttct tctgttctcg caatgtgctt 420gtacccttgt gtgaactcgc tcactctccc ccactcctcc cctctctcac tcactctgtc 480tccctctgtc tcttgtctga gggaagctag ctgccatgtt gcaagcagcc ctctggagag 540gcccatatgc caaggacctg aggcctttga gcaagtgagt ttggaagcag actttgtag 599378599DNAHomo sapiens 378ataacattat aaaacacttt ttttaagttt aaataaatcc acaaatgaaa ggtcaataat 60gaattaagag gacttgattg attgatagat agggtcttgc tcctgtcacc caggctggag 120tgtagtggtg tgattgatta tagctcatcg aagcctcgaa ctcctaagct caagcaatcc 180tcctacctca gcctcccaaa gtgctaggat tacaggcata agccaccatg cccaaccaag 240aggacttttt ttttttttaa atatgggaaa gcaattgcct aagagtgcag tcaggttgay 300ttcaaattcc aactctgctg ggtgacctta gggatgttac ttaacccatt tgggccttcg 360tatcccccac gtaaagtgag gggattgatt tacatgatca ttaagcttcc ttccacctct 420ggttaggata ctactttcaa atatcccgtg gggtcacttt cagagacatt gtggaggtct 480atttatgata gtcacttagg tggaaggtta ttggtgaaga ggggtaaagt aacaagatta 540aatttatctg tgcaccattt gctttttcac ctttagaata tgcccttgat gccaccact 599379599DNAHomo sapiens 379agaccatatc gaatttagca gtttttccat caatgccttt tctgtttcag ggttccatgc 60aggatcccac gtagcatcta gttgttattt ctccttaggc tcctgcagtc tgtaacaatc 120tgtctttatc tttcatgacc ttaacacttt tggtcaatat gaccagttca ttagtagaat 180atttctcagt ttgacaaaca ccacagtaat aattattgca agcaagatct gtcagtggat 240actaaaatca gtaggcagaa agttgagaag caagatattt acatagtctc aacatttcty 300tcctaagata cttgttaatt acaaagacta aaacagtaac tttacagtgg agaaacctgg 360ccaacaccat ctaagccaag tgaataagga ttaacatcat cagtaataag acatattgat 420atcatgattc catatccact gatatgatac cctgaaaaga acacaatgtc acttctgtgg 480tattcttcct aaaaatacat aacctcagtc taactgtgag aaacatcaga tactttattt 540ttaattgtgt tttctattta ggcaaagcat aattgatttg aaggagaagg aaataccag 599380599DNAHomo sapiens 380tcttaagatg gaacttaaag atgttgaaag aaaaattgca caacaagcag ctaagctaca 60aggaatagac ttagatcgaa ctgtccaaca agtcaaccag gagaaacaag agaaacagca 120caagttagac acaggtaata cagtctgtgt ccttctgtac tcatagagac tttgacattg 180cgagcacatg ccttttacag tcaattttat atctgttaca tggacaacga agttccttcc 240tgtccacata tatttgctct ttttttctga aaagcatcac ttctctttgt tctcttactk 300tgcacaacag attttgaaca gtaggagagt atgaaataag ctgtattctc ttttcctttt 360tttttttttt aagatagagt ttcacttttg tcgcccaggc tggagtgcaa tggtgcaatc 420ttggctcact gcaacctccg cctcccgggt tcaagtgatt ctcctgcctc accctcctga 480gtagctgggg ttacaggcac acatcactat gcccagctaa tttttgtatt ttttcgtaga 540gatggggttt cactgtgttt gtcaggctga tctcgaactc ctgacctcag gtgatccac 599381599DNAHomo sapiens 381ttttaccatc atgttttcat ctgaaaaaga aaagtctgga ctgaatgagc tttcctattc 60tttgatcatg cagcagtgac gggcacctat aaaatcatga aaactcatgc ttgaagccac 120acgctaatat aattgggagc acatggccta gattaagaat caaattagtg gttgatgcag 180tatagcatgc gtagtggtta agagcgtgaa ctctggagct ggactgggtt aaaatcttgg 240ctgcttcatt tactggctgt tgtgaccctg gacaaatcat tctctgtgtc tgtttgctcr 300tttgaaatat aggactgaaa atgatggtac tgtcctcata gggtcattga aaggagcaaa 360tgagttgact tttagagcct ggcacataga aagtgctttt attaagactg tgaagtctga 420cccctaaagt aagataatgg aatattatat aatactttat cttttttata tttttaggat 480gctaaagagc aggtaagccc tttggaaaca acattggaaa agttccagca agaaaaagaa 540gaattaatca acaaaaaaaa tacaagcaac aaaatagcac aggataaagt aagatttca 599382599DNAHomo sapiens 382ttgtactgta agcagtgaga attccaatta tagtctacaa aatgtatcag agaaaggaag 60ggaaaaaaaa tcagatgcag ttatagtata ccacaaatgt ttttccattc tactagaaat 120ttgatagtgt agggtccagt tctacctgtt actacttttt gtgaccttgg acaagtcagg 180tcacctacag ttctcttcat atattccttc agctgaaaac tgagaaaggc agttaagttt 240ccaaattatt ttattctgtg gactaaattt agcagggctt aaatcagtac gtaaataagy 300gactgttagg ctcctcagct cttaaatatt aaccccaatc atccaactca gatgacagtt 360aatgcatgca gctggtcacc tatggaaaca taaaaattag ctgcattcta gatacctgtg 420agagagtggc atgctgaaca gattacagtc caatgtccac caaaagtcta gctgggaata 480acaccacttc tacaagactg cctgaaagct atgcagtcca tccagtgctg gctcagttat 540tgacagctaa agggatatat tagaacctct aaggaatttc aacaaaacac acatatctc 599383599DNAHomo sapiens 383acaagaaagg tggctacaag ataaccttac tttaagaaaa agaaatgagg aactaaaaga 60agttgaagaa gaaagaaaac aacatttgaa ggaaatgggt caaatgcagg ttttgcaaat 120gaaaaggtat gcttttaaaa taatcttcag tttaaataaa cgtctttatt actggaatgt 180gaagaatatt aaatacctgt tttaaaagaa ttttagcctc agcctggtat cctttgagag 240ttactagaag gtgaacagtg ttttgataca attatatttc atggccttaa gaactttaty 300actgaagaag tgatatagaa ttggtaatca cactgtagtg atgggcctta gttattcagt 360attgaacatg cttagccccc atacatctgc tagcctgctg cacagaatag tggtactaag 420cataaagaat atggagctgt ggaccttgtc tgggtcagag cttgtacagt ctataatatt 480gtcaatggag ttgttgccag agtgatttat ccacagagat tcattttaga ttttctcatt 540tgtaattatg tgtccaccag agcatttctt ttgaaagatg agcctcattc ttcctttat 599384599DNAHomo sapiens 384gtatcctttg agagttacta gaaggtgaac agtgttttga tacaattata tttcatggcc 60ttaagaactt tattactgaa gaagtgatat agaattggta atcacactgt agtgatgggc 120cttagttatt cagtattgaa catgcttagc ccccatacat ctgctagcct gctgcacaga 180atagtggtac taagcataaa gaatatggag ctgtggacct tgtctgggtc agagcttgta 240cagtctataa tattgtcaat ggagttgttg ccagagtgat ttatccacag agattcatty 300tagattttct catttgtaat tatgtgtcca ccagagcatt tcttttgaaa gatgagcctc 360attcttcctt tatctggtct tattgttact tattgtagtt gctaccttcc tggtacagca 420gaaaagattt tattcctgcc ttgactgcct tagagttagt tgccttagga attctgtaag 480aaccttgttg atgctaaggc actagactgg tataaaaggt tgtactaggc aaatacttag 540attgtcaacc acctcagctg gttaaatcca ggcctctcat ttattaaacc cttccttgt 599385599DNAHomo sapiens 385cagaaaaatc

acagaggaaa ttatgatgaa agccaagaat gtgaccctaa tatcctagtt 60cccaagcctc agttctttta cacgatactc tccatggcaa gttggaaaag taatgcttct 120agaagaaatt ttgatataaa ataatatatt cgtggctact aaagaccaaa accagatatt 180taaaaaattt cttctgtaat tggtacataa cagtactttt tacattcatt cacattacta 240agtacaacta tttttcaaac gtttcttcaa ccaggacata acagaaatgc caacaagacw 300tgtaatccag tcgactctgt aaggatgccc ataagcttga gagtagtgcc tgacacataa 360gaggatgctt aataagtgat aataaataaa tgaagatttt taaagcatac attgaaattt 420gtataatctg ccaaaatatc agaaaagttt gaatatttta cttttttggt cattattatg 480gtttttacac ttgtgcaaga gaaattttgt tttcatggag gaatctaaat ttttaataag 540tattactgca gaaaattaat atatgattta attcgtattg tgcctttgac atgagcaaa 599386599DNAHomo sapiens 386aggatgctta ataagtgata ataaataaat gaagattttt aaagcataca ttgaaatttg 60tataatctgc caaaatatca gaaaagtttg aatattttac ttttttggtc attattatgg 120tttttacact tgtgcaagag aaattttgtt ttcatggagg aatctaaatt tttaataagt 180attactgcag aaaattaata tatgatttaa ttcgtattgt gcctttgaca tgagcaaaat 240gatgatgaag cctgttatcc ataacttctt agtgttgata attgtgcatt ctcagttcay 300aatcagaaga ttgtgaattt gtaatattaa tcaccagagt gctttactta gcgtctaaag 360gccaggaact ttatcagtga tcacatgcta tgagggttct gtaatacaca aaattagcta 420tttagcaacc tatgtgcggc agagatatgg aaggaagaga ggggttttct ttagtaccaa 480agccctaaat aataagcaag gagagactct gttataatat actgattgct aaggagaatg 540atacttaacc tatctaaaga aatctatgac ttttccactt caggttgtta aaagctaaa 599387599DNAHomo sapiens 387gctttattct aagacgtgaa agaatgaggg aaattttgta ccttactttc ttctgggtga 60gaaggcaaat ttagggctca ccgtataaat cttgagaagg ccactgtttg cgagcataag 120ccacaaagac tcaattttgg ggaaatttgt atcacctctt ttcatttaga agaatccatc 180tgagtaccag gtaagagaac tcagtaaaca gcctggcttt gttccttaac aagcctaaat 240tgctagaaag cactcctgta cctctccacc ccgccaggct ccaccaagct ccctcatagr 300tcctcattct gctcagcatg cctctgtgac tgaggcactt ttctctgctg aaaagccctt 360ccttcttatc ccaggcccag gtcaaaaaca gactatggag cacctaccaa ggtctccatc 420agacagactg tcagcagttt ggaggaggga cagggaaaga tattcctgtt ttcccagagc 480ctgacaagaa agtggcagag caagggttgt tgaattcttt tttatttttt ctcttatagc 540ctaatcttgg aagtgaaggg aattcttatt cctgctgcca ctggttctca gggtatgca 599388599DNAHomo sapiens 388gaaaatgcac tgctgacttc ctgtgttacc ttaaatagac agctgaacgc aacaattaca 60ctgactgcat gctttattct aagacgtgaa agaatgaggg aaattttgta ccttactttc 120ttctgggtga gaaggcaaat ttagggctca ccgtataaat cttgagaagg ccactgtttg 180cgagcataag ccacaaagac tcaattttgg ggaaatttgt atcacctctt ttcatttaga 240agaatccatc tgagtaccag gtaagagaac tcagtaaaca gcctggcttt gttccttaay 300aagcctaaat tgctagaaag cactcctgta cctctccacc ccgccaggct ccaccaagct 360ccctcatagg tcctcattct gctcagcatg cctctgtgac tgaggcactt ttctctgctg 420aaaagccctt ccttcttatc ccaggcccag gtcaaaaaca gactatggag cacctaccaa 480ggtctccatc agacagactg tcagcagttt ggaggaggga cagggaaaga tattcctgtt 540ttcccagagc ctgacaagaa agtggcagag caagggttgt tgaattcttt tttattttt 599389599DNAHomo sapiens 389ttttaaatat gtgctactac agataatgct gcagagtgtg tctttgcaca ctaaagcaga 60tatgtcaaaa agacagcttc ctagaaatgg agttactggc tcagatgtta tgtatatttt 120ttagttaatg ccaaattgcc ttctaaaaac acttagaaaa tttccaccaa tagtatatga 180aagtgcccat tccatgtctg gattttgtta ctgacatttt attggctgca caaaaaaagc 240ttgcacttta atttacattt ccctctttac tagtgaagtt aaatgtcttt ttgtatgttr 300tctatttgta tttcttctcc aagaattacc tattcatatc tctttgccag tttttctact 360aggttgtctg tttcttgatt tgtcacattt taatagattc tagatgttaa ttattttcac 420atacattgca agtacctatt cccagtttat cgtttgtcca tcaattttct ttcgtttttt 480cttttttttt tttttttttt tgagacagag tctagctctg tcgtccaggc tggagtgcag 540tggcacaatc tcagcttact tccttccgcc tccatctccc gggttgaagc gattctcct 599390599DNAHomo sapiens 390ggttggataa cgggtaataa tttttttttt atcttttgta acactgttga aaactttcca 60gttgatttga actgttgcag ttataaacta acgttctata tgcatttggg tttgtttctg 120gattttcctt tgtataccaa cttttaaaat ttattttttt tcttttgtat tatctcttct 180atatgaactt tagagtcagc ttatggattc tgttaagcat tttttaattt tattggggtt 240tctgtttgga ttgcatttaa tttatggatt atttgaggag aacggacatc tttgtaatay 300cacatctacc attctggact ccttagtatg catctcctgc tcaatcattt ccttttatcc 360tattgtaaag ttttacagct ttttcctcta gctcctatac ccttttgtta gacttattcc 420taggcatttt agggttttta tcgccactgt gaataggatc cttttttttt ctattgcctt 480tcctattggt gtttgcctct agataataaa acttcatttt tatatattta tctctggcta 540tctcattagt ctgaataatt tttcagttga ttttcttgga ttttctaagc atacaattc 599391599DNAHomo sapiens 391attctcatca acaagcagaa tatggttttt tccagtcttc tactacttca cagtccttca 60tctgatattt aaaatgtatt tatgttgagt catttctttc tctcttgctg gtgaaccaga 120agatcacgaa atgattctac agaggcagta gcattatatt cagtttcttt ttttgtatgc 180atcagataag aggcctgcaa atggaagtaa gtcgcctcac atcctcacat cctttgtatg 240atgatcgcag taatgtttgc ctttttacca ctggtgcaac atttattagt tcataaaccy 300gcttccaaag aacctaaggg ctttttgatg aaaggtgact gtggtgggaa caatgttagg 360ttttgacagg ctacttttgc ttttacaaac atttctcctc tttgttttta gtgtttagaa 420actactacct taaaagagag ttgaggacag ggacatgtct ggactaagtg gaatttagtg 480cttagagtta ggatttggaa tataaatatg gaagttaata tttagaatta ggatttctga 540atctgtgaag gaaaggtaaa ataaaatttt gatgtcagtt cagcttaagc ttctaaatc 599392599DNAHomo sapiens 392taggttttga caggctactt ttgcttttac aaacatttct cctctttgtt tttagtgttt 60agaaactact accttaaaag agagttgagg acagggacat gtctggacta agtggaattt 120agtgcttaga gttaggattt ggaatataaa tatggaagtt aatatttaga attaggattt 180ctgaatctgt gaaggaaagg taaaataaaa ttttgatgtc agttcagctt aagcttctaa 240atcattctcg ctgaaccaaa gcttccagtt ggtaaaaatc taagatctga ggaataaaas 300caacataaga agctgacttt tggtaagcct taacagtgat agaagaggga caaggtggca 360gttcgattct cctattttcc ccatagactg caggcccctt ggctaaccgt aaaccttcta 420ccctttaact ccctgtcgtc cattcagcag gccttcctgt gacccgtgag tatcagtgga 480agcattccct ccaataagtt accacggcct aagaaaaaag tctaaaaaat tatgtttcct 540gaagttttca cagtatttaa gtatttacgt aaaggagtat ttgttgtatc ctagagagt 599393599DNAHomo sapiens 393cctatcgtgg acaaggtgag taccatggtg tatcacaaat gctctttcca aagccctctc 60cgcagctctt ccccttatga cctctcatca tgccagcatt acctccctgg acccctttct 120aagcatgtct ttgagatttt ctaagaattc ttatcttggc aacatcttgt agcaagaaaa 180tgtaaagttt tctgttccag agcctaacag gacttacata tttgactgca gtaggcatta 240tatttagctg atgacataat aggttctgtc atagtgtaga tagggataag ccaaaatgcr 300ataagaaaaa ccatccagag gaaactcttt tttttttctt tttctttttt ttttttccag 360atggagtctc gcacttctct gtcacccggg ctggagcgca gtggtgcaat cttggctcac 420tgcaacctcc acctcctggg ttcaggtgat tctcccacct cagcctcccg agtagtagct 480ggaattacag gtgcgcgctc ccacacctgg ctaatttttt gtattcttag tagagatggg 540gtttcaccat gttggccagg ctggtctcaa actcctgccc tcaggtgatc tgcccacct 599394599DNAHomo sapiens 394acaggtgcgc gctcccacac ctggctaatt ttttgtattc ttagtagaga tggggtttca 60ccatgttggc caggctggtc tcaaactcct gccctcaggt gatctgccca ccttggcctc 120ccagtgttgg gtttacaggc gtgagccacc gcgcctggcc tggaggaaac tcttaacagg 180gaaactaaga aagagttgag gctgaggaac tggggcatct gggttgcttc tggccagacc 240accaggctct tgaatcctcc cagccagaga aagagtttcc acaccagcca ttgttttccy 300ctggtaatgt cagcctcatc tgttgttcct aggcttactt gatatgtttg taaatgacaa 360aaggctacag agcataggtt cctctaaaat attcttcttc ctgtgtcaga tattgaatac 420atagaaatac ggtctgatgc cgatgaaaat gtatcagctt ctgataaaag gcggaattat 480aactaccgag tggtgatgct gaagggagac acagccttgg atatgcgagg acgatgcagt 540gctggacaaa aggcaggtat ctcaaaagcc tggggagcca actcacccaa gtaactgaa 599395599DNAHomo sapiens 395ctgtgtcaga tattgaatac atagaaatac ggtctgatgc cgatgaaaat gtatcagctt 60ctgataaaag gcggaattat aactaccgag tggtgatgct gaagggagac acagccttgg 120atatgcgagg acgatgcagt gctggacaaa aggcaggtat ctcaaaagcc tggggagcca 180actcacccaa gtaactgaaa gagagaaaca aacatcagtg cagtggaagc acccaaggct 240acacctgaat ggtgggaagc tctttgctgc tatataaaat gaatcaggct cagctactaw 300tattacactc tcctgaagct aaccaacatt tcctgcaaca ttatgtagac ttttaaaaga 360agggcctgaa gcattctcac aggataggct aaatgtagaa caagaagctg aagacccgtt 420agagttttca tggcactcct tatcagaata aggtcactgt ctcatcagtt ataagacata 480ccactatttt atgtgccagc aggaatgaaa aaatgcaatt ataaccataa gatgtttcag 540aatcaatgac ataatagtat tgcaaaccag attctagctt aagctagaat gaatattcc 599396599DNAHomo sapiens 396gcaattagca tgccctgcta agacatctgc aggtagtggt agtgggttta ggactgtctc 60cccagctttc cacatgtgtc agagaactgt gaggaatgac agagctctta ctcaaaaagc 120ttatttgaga ttaggtaaag tccagtgagg gtaaaattgc acacctttta ccacattcac 180ctggggtcag tgtagacgcc aaggttgtca agcagctctt gcataaggac tatgctggca 240gagaaaaagg cagtttccct gaggtcaaag gaggtgtttc aggcactcct ggctccagay 300agtccctttc tggcagagag ggccagaagg agagctcagc agcgcagggc cacctttctg 360cagccatcat cacaagtaag ggcgagtgct tttgaaacct caaatgcatc cagctccagg 420aaggggataa gtggctagct aaaagaaaaa gtctttcagg tttcagtcac attgctggtt 480acctcagcaa aatgttccca gaacacccac tcaggtccct gtgtgtcata gtaatgatgc 540atctagtgac tggtggtggc agaattctaa gtagacccag ctcttaagaa agcagtgtt 599397599DNAHomo sapiens 397ctgtccaatt attcgcttac ccactaggct gagtagagac ttcaggaacc aaacatgaca 60aagcatatag aatttgcaga attagtccag gaaagacaca gaacaaacca acagcagcaa 120caataagaaa tagtaacagg tgcaagccct ggagagtagg taatctgact tcaataattg 180atagagtatt taaaacaaga cacacaaaga acaggaacat ctgacccatg ccataaacag 240caatttaaaa aacagtcaat agaaacaatc tatgaggaag cccagatgtt agacttactr 300ggcaaagact ttagatatca gctattataa acatgttcaa ggaactaaca gaaacaaagt 360ctaaagaatt aaaggaaatt atgagaatga tgtttcacca aattatcagg actatcagta 420aggagacaaa cattataaaa aagaatcaaa tagatattct ggagttgaga aatacagtaa 480tggaaataaa aattcactag atgggggtca acagcaaatt tgaactggca gaagaaagaa 540tcagtgagtt caaagaccgg tcaattgaga ttatacagtc tgaggaatag acagaagaa 599398599DNAHomo sapiens 398gatgctggga ctatggggct ttttattttt ttgcatatct gtactttaca caataacatt 60ttgtgtaatc tttttttaaa tgcagaatac tgacattgga gaatgctctt catatatttt 120aagtgaaaaa ggagtaaaaa ctatataatg tattatctca tttttctaac aaaatgtaaa 180tgtgcatagc aaagatacag aggtgttata gtgccaggga aaaggggtgc aagactagtg 240tttgcctctt atttcttgtc ttgtttataa attctctaca ttaaaaatat aaattccaar 300tgaaaacaat ggaataaaca caaactccca ctttataacc aactaaaatg acagtaactg 360aattttctaa agttttaaac ccaccaaaat gggagaaatg gatgacagca ccagcgtttg 420aaaggtggaa agtggaggga cggtgggcag actacttggc tgacccaaga aaactgaatc 480ctaggccagc tgagacctat gttgatttac agaatcccaa gaatgctcag gaactgggag 540aagaccaagg acatcagaag agaagggggt gaaaataagg aaagttgttg aaactcagt 599399599DNAHomo sapiens 399agaggaagag gaggaattag tcaattccta acaaaagcga gagagcagtg cgtgcagctg 60aagaaaggag taaagtctcg gagcagctgg agctctgtga tgagcacgtg tcttccagat 120cacagacagg agaggattgc acaaagctct ttgacttctc taatgcaagg gaccattgca 180tggcccacaa atcctttaac agtttgaaat gaatgtgcag actccttcac cccagctttc 240atcacctggg catttctcta tggttttaaa tataacattt gtttctaatt tgtgtaactr 300taagtccatg tgaacctcat ggatttttgg cttaggcaaa tagcttctct gtaattggca 360gcaattccat cttaataagg gaactgtgat ttgcaaaacg aaaaaatata ctgttttttt 420ctttttcctt ttttttattc aagggctagt gaatcttggg atctcagggt tacatcgagg 480tatatttatc atcatcatta tagtccagga ctaaaaggaa gttattccag gctctttgca 540aagaatctca gttttttttg tttgtttgtt ttattttgtt ttgagatgga gtcttgctc 599400599DNAHomo sapiens 400atgttcggtt tttttttttt gagacggagt tcgcttttta gttgcccagg ctggagtgca 60atgatgcgat ctcggatcac cacaacctcc acctcctggg ttcaagagat tctcctgcct 120cagcttccca agtagctggg attacaggca tgcgccacca caccaggcta attttgtatt 180tttagtagag acggggtttc ttcatgttcg tcaggctggt ctcgaactcc tgacctcagg 240tgatctgccc accccatcct cccaaagtgc tgggattaca ggcataagcc atcggccccr 300gctcattcaa gttttaaaca ttattgaggg cttatgatat gtcaggcaca atagcatagg 360tcactttatc cccattttta gaaaaaagcc tcacagaggc tgagtgattt gtcaaagtga 420caaagcttat agtggtggag aatgttggtt catggtattc cttgctcttc atgaaatctg 480tcatgggcct gagtaccttg tttggacatg tgtttttgac ctgcctgcat tctttgaggt 540taaggctgtc ttacacagct ggaatccccc ttggtgcgtg aaaccatctg ctgtagtgg 599401599DNAHomo sapiens 401agtactgcat ttcacaaaat gaaacccatt gttaagaaat tacaaattcc caataatttc 60aaatataaaa atttattcat gaaaattata ggttataaaa ttaaatgtcc gtcttagtcg 120atggttgccc atattttgat gaacgagtca ttcctagcct atctttgttc aaatgatttg 180catacattat gcaaataggt agaactgccc gaagaatgcc tacgctgcgt ggtgcggacg 240aaacgcttcc cggggccttt ggattggtct gtctagccac ctcatttgca tgacgtaatw 300taataactgg aaggccccgc ccctctggtg catttccccg ctccaaccac ctcctcaaac 360tcacggcaaa gggatgcgag agctggaact cttaccaggc ctgcggaaac tcagccctcc 420ggcagctaat cccgcccgcc agcccccgtc ctctctctct ttctccctag ctgaaggcgc 480cacgggccgt gtgtcgttgc cttccacttt tggcgtccca acgtctctcc gctcccatct 540ttctactaac gtccgacgca cgctccgcct ctttctccca cattcgtcgt gtaaattct 599402599DNAHomo sapiens 402tctcccgcgc cggaaaaggg cgtcagcgca cggttcaccc agactcacct ggccgggtgc 60gcggggatcc gggacccggg cctaggggct ccccgggacg ggatggcggt ggggcggggg 120aggatggcgg cggatggcgc cgggttcggc tcctcccgtc tccctcgctc actccgcggc 180tgagccccga ctaacggccc atccgggcaa ccgccgcccc cgggagcacc ccctcccacc 240tcccacctcc ctccgcgcct agacacgccc cttaatttgc ataaagggcg gggcactttm 300taccctaacc ctctacttcc agggctgtct ttagtttaaa aaaaaaaaaa aaagggccgg 360gcgcgcggag catgcggagg ttatttgcat aaagaggagg gacttaaggg cactaggacc 420ccgattggct aaggaggcgg gcccccagcg tcggccgttg agccgtgttg agggggcggg 480aatgcggtgc aggtcggctg ggcggttggg acgcagaatt tacacgacga atgtgggaga 540aagaggcgga gcgtgcgtcg gacgttagta gaaagatggg agcggagaga cgttgggac 599403599DNAHomo sapiens 403tgcaggaagg tatgctggga gtttaaggat tttatgagct tgctcagccg gaatgggggt 60tggtaccaga gaaatcctca tagaacaact agggctgtac atactcccag gctataggaa 120cctcaagtat ttgaaatatc ccatcttttc ctaaacttgc tcctgtattg gctcctggaa 180aaaatcgcct ccagatgaaa tactgtttta ccatatgaag aactgagaaa aagcattatg 240gagccacctt agcaccctgt aaccatgggc cagaaaacag agggccaagg ccagagccay 300cttcgttttc ctatcctcat taaaaatgtc catcaccagt gtttctttac tcgatacctc 360cagctcccta agcaagccgg acgacaggtc tctcagtcca ttccagagtg accaggcatt 420cgtttatgga cgggaacagt gtaaagagat gagaaatagt ggggaagaaa gcagggaaat 480ccagacaggc ccagaatgaa agctaaaatt ggggagaaag aactttatga caagctagag 540ataagatgga tgttgcttcg taggtgtttg aggaggccaa tctgtgaaga taaatatat 599404599DNAHomo sapiens 404tggcgcatgc ctgtaatccc agctactcag gaggctgagg caggataatc gcttaaaccc 60aggaggtgga ggttgtggta agtcaagatc acaccattgc actccagcct gggcaacagg 120agctaaactt ggtctcaaaa aaaaaaaaaa aaaaaaaaaa atctatgaaa tccctatcaa 180gaaggctgag atatgtaaca ttcaatactt ttatgtgaga ttggttgatc atgagcctgc 240aagaagcaag ctggcctcaa agtttcccaa atccacattt attttcctcc aattcttacr 300tgtccaaaga cagggaacca cagacacgcc tttgtaggag gataactggt gttcacccag 360agcccacacc ccctttaaag gacccagtgt aaagttggga aatctcctct agtcttttgg 420tatttctact acagccactt ccctttaaag agctctaaaa cgtatgcccc atgcatgcct 480agctttcaac catcagaagc atctttgcag gactctcacc agcgggtttc tggatctcta 540aggacttgcc cttatacgta tcaaacaggt tgagcgagga atacttcttt ccatccttt 599405599DNAHomo sapiens 405aaatatggca tgttgtataa ccacatgcga gactgatcct agactgagcc tcctggctag 60aaaaccatct cctcccccaa taagcttccc ctgcccccag ccacaaaccc agacctggat 120tgctcacctg ggcccatcag gagtggggta tcggtaaggc ccctggggtc catagggcgg 180agggaacggg agatatgggg gatacatctg taaaagggtc caacagtagc tgctcagagg 240gacagtcata tacccttcta gctccttaag cctgctatca atcatcctcc caccctcccy 300tctatctcat aggtcaaaga ctaagtcctg attcctagct ctccagcttc cagtgtaatc 360gttccaagac aagacaccaa gactcacgaa aggcggcatc attccgcggt agggagggaa 420ctggggtggg cctgaaggct gtagcccacc ccggggatca tgaccatgat gaagtttgga 480gtccgggccc tccagctcat cagggccacg cccacctccg tccctccaag ttgtagaatc 540tgtattttgg aaaaggtaga gagaggtatc aatgattgga ggacaagtga acacagctg 599406599DNAHomo sapiens 406ggtggggcag caggctctgc tttgagccgc ttgtcaggtg ccccaaactt ttcatcgagt 60cgcttgagct tctcagcaca ggctgcccgg cgctcttctt gcatgcgccg ctcctcttct 120tctcgccgtc gccgggcccg ctccactgcc agggaaatct cagatgacga ctgctttcgt 180cgctgccgcc atgcctcatc ctcatcttca ggtgctgggg gcttgcaggg aggaccccca 240cgatcctgtc aattggcaag acccagcagg gccaggggaa tcagttacta tgctttctay 300catctctttt acaacaaatc aactgtcgct acttgcagga tgcaacgacc caggctttgg 360ggttgatctc tctgggtggt gacaaactca ttatcctggt cttctttgag accacgtctt 420gctatgttgc ccaggctggt cttgaacttg ggctcaagtg atccttctgc ttcagcctgc 480tgagtagctt ggactactga tgcatactaa cagatccagc tatctagcca ccctagtctt 540tttatttttc tgttccctct ctccttccga aacccaaaca cccagggctc ctttttctt 599407599DNAHomo sapiens 407gacaggggac caggggaagg gggaggaggg gaagtgaggc cccagcccca gaacccctcc 60ccgcccaccc ctttccccct tatatattta taatctatat acaagccccg ggggtagggg 120gcaagaggaa ctccctcagc ggggtggggg caacccaggc tccttgtccc ctcgggaccc 180aggctcctct gcccgtcggg agggcccttc tcgaggtggc ggccctgtcc gctcccaagg 240cttaggtatc cagcgcaggg catctggtgg ggaggcctag gggacaggca tgtgttaaas 300agtgagtcac agtgagaggt cagcgatgag acggaaggac aggaaatcag gtggcaactc 360gaatttagag ttggggccac aagggtttct ccttcacctg ctggtaaagg tcgacgcgct 420gggtgcggaa gactccactg taggtggaag gcgtggcctt gagacgggaa ttgaggccag 480agaaggacct aagggaagaa gggcgtctaa ggcaagccta ggatccagac cctggttcca 540aagtaaggaa gcacttggaa agtccacatc cctattccgt ttcaccttcc agttggggg 599408599DNAHomo sapiens 408caccaacaca gctaccacag ctggccccgc tcctgggggg cctgcccagc ctccacccac 60ccctcaaccc tccatggctg atcttcagtt ctctcagctt ctggggaacc tgctagggcc 120tgcagggcca ggggctggag ggtctggtgt ggcttctccc accatcactg tggcgatgcc 180tggtgtccct gcctttctcc aaggcatgac tgacttcttg caggtgagtg gctggcttgc 240cattcacctc atcttcctgt cccccggccc agccaggcag tggtaccttc ttgccattay 300ataaccactg ggtaagagcc cctagtgaca tgttagggga aggggccctg ggaattcatt 360gactctgaac ctttcatttt aaagatgaag aaaatgaggt ttagaaaaag aaagtatagt 420aattagtgtc actgctttct gacagcctgt tcagaggaag aggtaggtaa gttgtgctgc 480ctgactctgt taaataccta ccatacttct gctttaagca gtgaagatca gaatgtaact 540ccccatcttc ccagacccgt tggtttgtgc cctcttgatg

ccgtattatt tccgtgtgt 599409599DNAHomo sapiens 409agcagttctc atgccttggc ctcccaaagt tgctaggatt acagccaaga gccaccatgc 60tcagcccagc tttctttttt tggtttctta cagctcaggg gaccccaggt atggctccac 120cgccagcccc tgccactgct tctgccagtg ctggcaccac caacacagct accacagctg 180gccccgctcc tggggggcct gcccagcctc cacccacccc tcaaccctcc atggctgatc 240ttcagttctc tcagcttctg gggaacctgc tagggcctgc agggccaggg gctggagggy 300ctggtgtggc ttctcccacc atcactgtgg cgatgcctgg tgtccctgcc tttctccaag 360gcatgactga cttcttgcag gtgagtggct ggcttgccat tcacctcatc ttcctgtccc 420ccggcccagc caggcagtgg taccttcttg ccattatata accactgggt aagagcccct 480agtgacatgt taggggaagg ggccctggga attcattgac tctgaacctt tcattttaaa 540gatgaagaaa atgaggttta gaaaaagaaa gtatagtaat tagtgtcact gctttctga 599410599DNAHomo sapiens 410gaatccgctg ccgcaggaag atgagcatca gcagcaggat ggcttcaagc accgccaaca 60cgatcactgc agaggacggg gcagacagac ctaggtcagg gccagggctg gggccgggca 120tggcccaggg cggtccttgg gcagctggtg gcttgggggt gggcaggaca ctcacgggcg 180gccagccagg tctcctgcac gctctggtag gcactgaggt tggtggtgaa acccagctgg 240gagatggagg cgcccttgtc ccgcagcact cggtactcct cccagcagta gtagatgccr 300tatgccagca cgcccagcac tcccaggatc agcaccagca ccaggggccc agccaccagg 360cgcagaagca agataaacag taggctcaag accagagcca cccccagggc actgtaggca 420gggtgaggac agtgaggttc agccctagcc cctcaaatct ttccccttac agaggccctc 480cctgcctttc cacacaccac ccaatgtccc cagattaggc ctctttccct tataaatcct 540gttggtcttg gaatccattc ggagctctgg ctcctcctcc tctgtccaaa gcctgtgtt 599411599DNAHomo sapiens 411tcagtgggct gcttttgatt tcacaaatgg gcttctgccc tgtggagccc agtctatccc 60ctgcctcccc tccctgtcgt gccttggttt ggaccctcct ctccgctggc ctcaactctt 120agaacaccct gtcacccttc catccaccct ccacccgagt ggagtgccag ggagaccgtg 180gcactgcctg gacttcatca ctccagggtt ctgggtccct ttgtgactca gacatctcca 240gaggctctgc cccagagaca gcatccacac tccctggcca ggcttccagg ctctcctgts 300caaatccagc ccatgttccc ttctactctg tacctttgct cttactgtgc ctctctctca 360gggctctctt tccaccagaa atcccatcca tgactccctg ttcaaatcca gctccatctc 420acctcctcca ggaagccttc tgaccttatc cccacctcct ttggcaactg ttatgtgcct 480acagagccac ttactgccat ccttgcaaca actttgccag gcagccttgc tttgtcattt 540atttatctat ttatttattt attttcttat ttttgagtca aggtcttgct ctgtcaccc 599412599DNAHomo sapiens 412atcccagcac tttgggaggc cgaggcgggc ggatcacaag gtcaggagtt cgagactagt 60ctggccaaca tggtgaaacc ccgtctctac taaaaataca aaaattagcc aggtgtggtg 120gtgggcacct gaaatcccag ctactcggga ggctgaagta ggagaattgc ttgagcccag 180aggcggagtt tacggtgagc cgagatggtg ccactgcact ccagcctggg caacagtgag 240actccatctc aaaaaaaaaa aattagacaa tttatagcat aagatgagat atccagttay 300caatttaagt acagtaagga gtatctcaag tgaatacttc aaagtcaagt agatctgaat 360ataaattcta gcactttcca gccctatggt cttgacccaa ctatgcaacc tctctgaacc 420ttgtttcctc atctttagaa tgtaaatgac agtgaggtgc agtggctcat gcctgtagtc 480ccaactgctc aggaggctaa ggcgggagga tcacttgagt cctggagttg gaggttacag 540tgagctatga ttgtgccact gcactccagc ctgggcaata gagtgagaaa ccctgcctc 599413599DNAHomo sapiens 413ttaaaaaaaa ttagccgggc agtagtggca cgcgcctgta atcccagcta ctcgggaggc 60taaggcagga gaattgcttg aacccaggag gcagaggctg cagtgagcca agattgcacc 120actgcactcc agtctgtgtg acagagtgag accctgtctc aaaataaaaa agtaaaagca 180ataaaaaaat aaaaataaag cctactgatg cccatgctgc agcatcaccc aactctctaa 240cccttaaccc ctccagacca taagccctac ctccccaagt ctccttagct cagcctcccr 300tttcgtttct ctctcagaag ctgcacagat gtcatctgct gcgtcctctt cctgctcttc 360attctaggtt acatcgtggt ggggattgtg ggtgagtttc cagctgctca gagccagggc 420agtgggtgag ggacaggaac ccagggaggg accattccca taactgcccc actaagtccc 480tgccctccaa tgactcatct gtgcctctgt ctgcagcctg gttgtatgga gacccccggc 540aagtcctcta ccccaggaac tctactgggg cctactgtgg catgggggag aacaagtga 599414599DNAHomo sapiens 414ccttttccag cttcccagcc ccttcttccc gtcttctgca gggacgtggc tcggggctat 60gagaacgtgc ccattccctg tgtcaacggt gtggatgggg agccctgccc tgaggattac 120aagtacatct cagagaactg cgagacgtcc accatgaaca tcgatcgcaa catcacccac 180ctgcaggtga gtagggggcc cggggcctcc ccaaaaggac accgagagct gccaagtaca 240gttggacaag cttcaaacca gcaaaggcac ctggccaagg aagggttggc tgaaagggak 300ccctggtgtg gggtcgcatc cccaccaggg gagggatcct tttcctaggt cacagcaagg 360tatcatatga gctcccagta gccctgggga caccaccata ctgattaccc gtcaccctag 420gaccatcacc acccactgtt gtaacacatg gaccccaaag aaaggacagt ggttaggggg 480tcagggggca tcaagagtag aggggcccag accgatcatg gggttgagct gacctctgcc 540tcctcgcccc agcactgcac gtgtgtggac gactgctcta gctccaactg cctgtgcgg 599415599DNAHomo sapiens 415ttcccagggc ccaggcatcc tggacccccc aactctctac tgggctgacc agccctcctg 60tcccttgtct cccctcccag ggggaggccc ccgctgagat gggggcgctg ctgctggaga 120aggaaaccag aggagccacc gagagaggtg agtgcagcta aaacgggccc caattggacc 180gtcaccttcc ctaaacacag gatctcctga gcccttagct ctgaactttt tctcttcctc 240tacagttcat ggctctttgg gggacacccc tcgtagtgaa gaaaccctgc ccaaggccam 300ccccgactcc ctggagcctg ctggcccctc atctccagcc tctgtcactg tcactgttgg 360tgatgagggg gctgacaccc ctgtaggggc tacaccactc attggggatg aatctgagaa 420tcttgaggga gatggggacc tccgtggggg ccggatcctg ctgggtgaga ggctgggtag 480cctggggggt tggtgggaaa tttctgactc ttgccttctt tcttatcttg ccttttgctt 540gcctgttttc taggccatgc cacaaagtca ttcccctctt cccccagcaa ggggggttc 599416599DNAHomo sapiens 416agctaatttt cgcattttta gtagagacgg ggtttcacca tgttggccag gctggtctcg 60aactcctgac ctcgggtgat ccaccttgct cagcctccca aagtgttggg attacaggcg 120tgagccactg cgcctgaccc aaaagaactt taaaaattct gtttttctat ctcatctctt 180cttttccgca ttgccaaact tctcagaaga atagttcaca ttccagtgag agcagaaata 240caaaaagctg tcaagttaag aattagagtt tgtaaaattt tgtttcttgt ccctttctts 300ctacttttcc tttctaggaa tgtagatggg acagggggcc taactcagcc catggctcaa 360gacaggtagt ccttggtggc aggtggagtt gacagccaat gaatccttca agtgtccagc 420ccacccagtt acaactctgc gtaaaaacaa gcagaggtgc acaaactctt ttccatgtag 480tctggtggag agatgatgtg gagccatttc ccatgcatcc catccagggg gtttacaatc 540atctagatcc ttgtcccttc ttccccaact tctgccagta taaaaccagg ggctttcct 599417599DNAHomo sapiens 417tcaagcaatt ctcctgcctc agcctcccaa atagctggga tgacaggcac atgccaccac 60gccaggctaa tttttgcaat tttagtagag acagggtttc gtcgtgttgg ccaggctggt 120ctcgaactcc tgacctcagg tgatccaccc acctcagcct cccaaagtgc tgggattaca 180ggcgtgagcc accatacccg gccaacatca ttctcttaaa ctggcctttc ctccttcagg 240atctcacact ccctatagcc tcgcttctgc tttctgggat cacctaaatt aactacctay 300ggccaagtcc tgtctcaagc tctgctgtca gggtcaccaa aattaagatc atccctttcc 360atcctcctct ccctataaac tactgccctt cttccacaaa ctccttccac gccagcaaac 420ccagactgta acattaacac agagttataa tccatccata tactggtctc tccacattcc 480tggagcacaa actgctaaag ggtaggaacg ctgtgacacg tttggttccc ccactgtcca 540gtgggagaga gatatgtgag ccagtcagcg ctacaccgag ttgaggcagc cattgaggc 599418599DNAHomo sapiens 418cagctactcg ggaggctgag gcaggagaat cacttgaacc cgggaggcag aggttgcagt 60gagccaagat catgccactg cattccagcc tgggtgacaa gagcaagact ctgtctcaaa 120aaaaaaaaaa agagtacaca aattgagact ccccttggac agggctaagt gcatgaaaat 180caggacatcc tggtgttagg gactccaaag tggctgctgt ggcagagctg ctagtgcctc 240ccctgcccct caagtatctt ttctccctcc ttccacagta agagatggtt aggggaacay 300acagtcaccc agctaaagac catatttcct agcttccctt gcagctaggt agccaggtga 360cttggttctg gctaatggga tgttagtaga acttatgtat gtcatttcca agttatgtcc 420ctaaaataaa aaggcagtgt gccttttctt ttcatgggct ggaatataaa cctagcggag 480atccgtcttc caccaggagg atgagggcaa catgctgggg atgacagagc aaacagacag 540aggagcctgg gtgtctgaca cagtgttgat gtcataccag ccctgcacag ccacttaga 599419599DNAHomo sapiens 419tctcaaattc ctgacctcat gatccacccg cctcagcctc ccaaaatgct gggattacag 60gcgtgagtca ctgtgcccgg tcttattttt tttttttctt tttgagatgt agtcttactc 120tgttgcccag gctggagtgc agtggcacaa tcttggctca ctgcaacctc catcttctag 180gttcaatcag ttctctaagg actcacttat aaatcaaaag ggtttttacg aacctaaatg 240atcacttcag agaggtttca tgttcatttt tttattggtc ttatttattt ttaccctacr 300ttgttcaaaa aggtattgaa aagacttctg tgggtcaggg agactaacac actagcttca 360agtttctttg cttcctgcat ttcatacaag tgtaggttat gatttaaagg catatcccag 420cccccgcaaa agttttattc ctttgagtaa ccaaccccaa atgtatttac tttgccagtt 480gggaatttca tctactagac tttccgtaaa aatgttgtaa acatttttcc tgtctccaaa 540actaagtgtt gatttcattt tttccaccta gattatctct agggaaggat tgtagggaa 599420599DNAHomo sapiens 420agccttcagg agggacgtca tctggccagc tcatcatgct gtacactgcc tggagggcct 60tcttggtgtt agtccctgac ttcaacttgt ggtctgtgga gagggaagag accatcacct 120cacctggtct tccaagccat cttttaaccc cagagaccaa tctgcaactg aaatcccaca 180tctttcaact ttttaagtta atcatcatta cacggacttc cctttgacca caaagtggcc 240cttccagccc ccaacaggtt cccactaacc tccattgccc aacgatcctg ctgttcaacy 300tttgactaca aagtggtcct ccctgtcgcc ctcaaggtag tctcatgacc ccctccaccc 360tgaacctcct gaccccaaag tgaacctccc accattccct aacctctgac cttcataatt 420gatttcattg agctgcttcg tgacccagtc tgcattactg ctgtctgctt cagacacttt 480gacccaaatt ttggggtatg tggcatatgt cactagacca tatcttggct tcacaccata 540acttgccacc tgtgggtgag gagaacaagg cgccatggca ttgaaaatag aatactgtg 599421599DNAHomo sapiens 421atcaatgctt tggcttccaa gaaagacaat gagcaacatg tgttcaaagt caaggatatg 60gaaaacctgg aagatgtttt ctaccaaatg atcggtaggg agatacaagg gaataaagaa 120cacaactctc ctcaggttcc cctgaagtaa ttcattcttc ctctacacct gaagctctag 180ttgcctggaa agccttcttc attcctcctt ctctacctca gtgtcactat tcttgtttcc 240tggcactgtt cacttaacct tagaatcaca gagctctgag cacttcagag atctttctay 300agtcctacat ttgacacgtg gaaacagaag ccaaaggagg tcaagggaca gcaagttagc 360aacaagggtg ggcttgaaaa cagccaggcc tctgacagct tgatcccaag ttctttccct 420tttcagtcca ccatagcagt tttctcctaa cacgaggaaa caaatacccg tggtctttcc 480ctttctcctt ttgggccttt gctccccata gactcctacc caaaaggctg ctgccatttg 540ggaatgaagt gttccgagtt ttcagcacat tctccttctc tgccagatga aagccagtc 599422599DNAHomo sapiens 422ggatctggaa cacaggtgtt gtcgcagctg ttttaattca atcccacgcc cctgtccagc 60aggaaacccc ttatagaaaa cccaaatcct catcttggag tttctccttc agccagggca 120gcacttgaaa gaggttgatg tgaaagtctc gggcgtgagc aggtacctgc ttttgccgct 180tctggttttt gcagacatcc actactcccc agctgattac accaacctgc agaggcagtg 240gggtgccatg gatcattcag tagaattcct aatcctggaa gcatggctgt tcctgcttgy 300gtcttagctg acctaaagga atcagactag ggacccagct cagcctcgtt cttgacacac 360gcaggcaaga catgcggtcc taaggtgagg caggctctgc ctacctcgaa ttactagcca 420catgcattga gctttcctgc tttggggccc atgctgacca cttggcatct ccccagatag 480gaaagggagg actcacttga atgaaacgac ttctcttgtg aactatcaag gggccgccag 540aatcacctgc aaggagagga gaagctgtag agaaaaggac tgttgggcct tgggcactt 599423599DNAHomo sapiens 423gttggttcct cttgataaag aaagcctctc cctattcaca cagaaaaact cacattctca 60gattccttat tcagtctcct cctaggatag caactcctgg aataacttct ttggtttatc 120tgtaatgttt tcctccccat cctctgcctc ccctcttctg cttcagctca acgggaccca 180ggtggagtct gtacagctca aagtcaacat agcccgaaaa cagcccatgc tggatgccgc 240tactggcaag tctgtctggg gctccctcgg taagaatggg attcttcctt tcccatccty 300tcccccacag gccattcctt ttggttcccc cacacatcct tgggtttcct agagatgatc 360gaggtcagag tgtgtgcgga ggctatggga atgggaagga aaatttcaga tcctctgtca 420gttagaggta aagaaaggag agaaaaggat tgaaaacagc ttccaaagca gtgactggaa 480cagggaagaa agtgggagct ggagtgagat tggtgaggaa gatgagtgtc tcatggggct 540tgttcatttt gagatggagt agagtgagtt tcataagtat tcgaaatcag ggatctgga 599424599DNAHomo sapiens 424gtggtgccca ctcctcagcc tcccctcccc gaagccgcag ccgggaccgc agccatgaga 60ggaaccggga cagagaccga gatcgggagc gggatcgaga ccgggatcga gacagagaca 120gagagcggga cagggatcgg gatcgggatc gagatcgaga ccgggaacgg gacagggatc 180gggagcggga tcgagaccga gaccgagagg gtcctttccg cagtgagtga ttttggctgg 240aggtcaaggt gaccttaact gaggtttatg tgggtcctac taagtgaaat gtggcatggk 300ctatgtcttg tgactatgat ttgtgctccc aaagggtcgg attcattccc tgaacggcga 360gcccctagga aagggaatac tctctatgta tatggagaag acatgacacc cacccttctc 420cgtggggcct tctctccttt tggaaacatc attgacctct ccatggaccc acccagaaag 480taaggatgac aacagggcat gatgagaagt cctgggagaa tcctggggtg tgagacctga 540gggaagaagc tgccctccct gcagccgcct attatcactg ggtttggttg ggtccagaa 599425599DNAHomo sapiens 425tactgaatta cctggggcag attttggatt tcagaaacat ggaggctgga cctaggaatg 60tgcattttta aaaagctccc tggctaatca tgaagcacac tgaaattgga gactcactga 120ttttagaaaa aggggtccca gacctaagga tgaaaggttg gaggctcaaa gcctatcatc 180tcagtcacca agtgccctgg tgcttggata cagaagggag ctccacggag aaatgccaca 240tttgaaagag cagctctcaa agcaaaaata tccccagccc tttctgctct gtcctcacay 300gtactgcagg tacactgggc tgtaatctgt ccagcacccc ttcaggctgg gatggacagg 360agtacaggca cagatgaaca aggttaagct agatcctact gtgaggaggg tgaaggaggt 420ttggactcaa tgcgggtcaa aggttagggt caaaagtcac tcacgctact ctctggagct 480ccaggcaagt tcagcagctc ccagtgcccc gtgcatccga gctccacggc ccgaaggggt 540aggtccaggg gatctggagg gggtagcact acggggaaag gtcaaaagtc aggggtcaa 599426599DNAHomo sapiens 426gagctggagt tggacaatct gaggagcaag ccaacaaggt caaccttgtc atgtccatct 60ctgttcctta ggagaaggac atgacttctc ctacacccca ctcaaaaact aaaactaacc 120ttttggtgca aagtccatgc ctttcttgaa accaggtgga atagtaagaa gatctgtagg 180atagggacat gaaatcaggt cactgcacac tggtgaacaa attgtgtaca ttatataaac 240ctaaaagata ccatttacag gacagatgct gtagataggg atgtttgcta tgacacttty 300ccaacagatg acagtaaagg ttgttgtaga aatttcccag cagatgacag taaaggttgt 360tatggacaga atatcttttt ctaattttct caaaaacatg ggagggctag cagtagccca 420gtgatagcct gggctcttcc tcctcaaggc tcagactcag agccccacct tacctttctc 480aaagtctatc tcctcctcag cctcctcccg tgtgttcaga tctgttatgg tgggttcatc 540catcccccct gggaagagac aggacagaca gggattcatg ggatgagggt aatacgaga 599427599DNAHomo sapiens 427cagtgtcccc tctgggacct cctggctgtc ccactgcctc attctcatcc tcgtcacccc 60cacccaaatc cagaggctcc aacatacagc taaggcttag tagtccagga gctggagttg 120gacaatctga ggagcaagcc aacaaggtca accttgtcat gtccatctct gttccttagg 180agaaggacat gacttctcct acaccccact caaaaactaa aactaacctt ttggtgcaaa 240gtccatgcct ttcttgaaac caggtggaat agtaagaaga tctgtaggat agggacatgr 300aatcaggtca ctgcacactg gtgaacaaat tgtgtacatt atataaacct aaaagatacc 360atttacagga cagatgctgt agatagggat gtttgctatg acactttccc aacagatgac 420agtaaaggtt gttgtagaaa tttcccagca gatgacagta aaggttgtta tggacagaat 480atctttttct aattttctca aaaacatggg agggctagca gtagcccagt gatagcctgg 540gctcttcctc ctcaaggctc agactcagag ccccacctta cctttctcaa agtctatct 599428599DNAHomo sapiens 428caggggtagc agtgataaag atacaaccag agggctctca attagcactc ctcccaaaag 60atgtcccttt cttcccctca gacccatcct agccagccca catcctggtg gcaaggctct 120ttcttgcctc cactacacag aaccaccaac cttcaacact aggtcttcca agctgcttgc 180tcgggccagg ggagcactgc agggagaggc tgaaacagtg tcccctctgg gacctcctgg 240ctgtcccact gcctcattct catcctcgtc acccccaccc aaatccagag gctccaacak 300acagctaagg cttagtagtc caggagctgg agttggacaa tctgaggagc aagccaacaa 360ggtcaacctt gtcatgtcca tctctgttcc ttaggagaag gacatgactt ctcctacacc 420ccactcaaaa actaaaacta accttttggt gcaaagtcca tgcctttctt gaaaccaggt 480ggaatagtaa gaagatctgt aggataggga catgaaatca ggtcactgca cactggtgaa 540caaattgtgt acattatata aacctaaaag ataccattta caggacagat gctgtagat 599429599DNAHomo sapiens 429gggctccatg tgggagagga agtgcgggcc atgagtctgc ggagggactg gctaacttca 60tgctctcttc ccagcaccat ctacacttcg cccatcaagg ccctgagcaa ccagaagttc 120cgggacttcc gaaacacatt cggggatgtg gggctgctca ccggggatgt acagctgcat 180ccggaggcct cctgcctcat catgaccaca gagatccttc ggtgagagat ggacactcaa 240tacaggggag ttttggctgg gaagatgtgg ccgttgtgga gagtgtgctg tctgaggagk 300gggtggagac gagccactgg ggagtcaatc cttggcctct tctccccagc tccatgctgt 360acagtggctc agatgttatt cgggacctgg agtgggtcat ctttgatgag gttcactata 420tcaacgatgt cgaggtaagg gccatgggct ccccagaacc cggcagtcct ctcctttggg 480accagttgag cgtctccctt attccacaca ctcagggccc cttactgctt tctttacccc 540catatggaat cctgtgcctc tttatgggca gaagggcggc ccctgccctc atgtgacct 599430599DNAHomo sapiens 430gggcacttac agggctggag ggggtcacct gggggactac ctgaaggtga aggtcaggaa 60tgccacagcc ctggcaggga gaaaggggtg gtgtccccta cctgcttgag ggtgtttggg 120agctgatccc cagcgtcccc agggctctgg cagaccaggc cagagagcaa ggcagcaatc 180tcctcaggcc gcagggtgct cagtgcattg tcaaacatga gctcagtgag gagcaactca 240tggctgctca tggcacaagc cacccgccct gccagcttca cagtgcccgc ctcgtccacr 300taacccaggg ttcggagcac ctgcaagaaa aagggtgggc attggacaca ctgctgtccc 360ctagcccccc tgccccaacc actgccccac ccacctctac tcgctgatgg tactcaggaa 420gcagcagcaa tgactgatcc gacagtagga agcgcagccg ctccatctcc ttctgtatct 480gcattcgctc ccgcagcttc aggtactgca gagagccacc cgtcagcctt ctccttgccc 540cttagcaggg gtgcactgag gacaagggct gagatggggg cggtcagtct acaggggac 599431599DNAHomo sapiens 431ttttatttgt tttaaacatt gaatcccata ctcctcccca ccttacccta cccagaattt 60agactgttaa tgttttgaag ccacagcctg catcttaatc actattttat cttagtgcct 120ggtcttagaa attatattga ctctttgata gaccatatat aaggcaggtg gatgagaatg 180tgggtagcta gttggaaaag gctgcttggt catttgcttg attattttct cacacagttt 240ttcctttact aagagaaaat gcccccatat tggcaaacaa aatctccctg cctgagagcr 300cccagagtat agcagagcat cttaccctga tacgcctctt ttcactctct tctctgtgga 360gacagaagga gcttcaagag cagggggaga tcagaatcgt ccagctgggc ttcgacttgg 420atgcccatgg aattatcttc actgaggact acaggaccag agtatgtgac tgtgtgcgtc 480aggggtgctg gggggagggc acaggttggg ggagacaggg aacttgggaa acagaaataa 540aaacaaaaga aagaatttcc ctgcccccac atcccatgga gagggcacag ggccctggt 599432599DNAHomo sapiens 432cctgagccag atacagcctc tcaaaattag atttttattt agctcctgcc cagttgtttt 60ttagctttgg gttttttttg ttttaatgtg aatgtttagg ggtatcccag ctcctaccat 120tctctatcct cttagtccca gtatgattaa catcaagctt ttacacttcc tgccaggccc 180ctgtgtgctt ttgataagcc accaagaact gaattctatt tcagggctct ttctaaggcc 240caggtaagat aggcctcctc tcttgtgggg aggaatacaa acttgggtca ttttattaam 300aagaagagtc agctttttgg cagcttttct ggcaggttca ccaaaaaaac aggaggacag 360gctggatgga actggaggga ggcagggaag caccagatgc ctgactttgg ttggttccac 420aagtctcacg tgatttctga gtccctgaag ccaaaggtct gtgtcatttg gtcctgctgg 480aaactaaggt ccccacaggc tggaagtact gaagctagaa

atttctgcac tgccccagca 540tacggtcggc catcacaggc cttgaggacc tacaagcaga gatgagagac atggtccat 599433599DNAHomo sapiensmisc_feature(300)..(300)n is any nucleotide 433ctgtaagggc cgggggcatt ttttctttct taaaaaaatt tttttttaag agatgggttc 60ttgctatgct gcccaggctg gtcttaaatt cctagtctca aatgatcctc ccacctcagc 120ctcaagtgtg agccaccttt ggggcatccc caatccaggt ccctggaagc tcttgggggg 180gcatatctgg tggggagaaa gcaggggttg gggaggccga agaaggtcag gccctcagct 240gccttcatca gttcccaccc tccagccccc acctcctcct gcagacaagc tggtgtctan 300gaactacccg gacctgtcct tgggagacta ctccctgctc tggaaagccc acaagaagct 360cacccgctca gccctgctgc tgggcatccg tgactccatg gagccagtgg tggagcagct 420gacccaggag ttctgtgagg taaggctggg ctcctgaggc cacctcgggt cagcctcgcc 480tctcacagta gcccccgccc tgcccgctgc acagcggcct gctgaactca cactgtttct 540ccacagcgca tgagagccca gcccggcacc cctgtggcca ttgaggagga attctctct 599434599DNAHomo sapiens 434gtggccattg aggaggaatt ctctctcctc acctgcagca tcatctgtta cctcaccttc 60ggagacaaga tcaaggtgcc tcacagcccc tcaggcccac ccccagcccc tccctgagcc 120tctccttgtc ctgaactgaa agtactccct ccttttctgg caggacgaca acttaatgcc 180tgcctattac aaatgtatcc aggaggtgtt aaaaacctgg agccactggt ccatccaaat 240tgtggacgtg attccctttc tcagggtgag gacctggagc ctagacaccc ctgggttgtr 300ggggagaggc tggggtggag ggagaggctc cttcccacag ctgcattctc atgcttcctg 360ccgcagttct tccccaatcc aggtctccgg aggctgaagc aggccataga gaagagggat 420cacatcgtgg agatgcagct gaggcagcac aaggtgggga ctgtacgtgg acggcctccc 480ctcggcccac agccagtgat gctaccggcc tcagcattgc tatgaggcgg gttcttttgc 540ataccccagt tatgggcctg ttgccactct gtactcctct ccccaggcca gccgctcag 599435599DNAHomo sapiens 435catcagggtc ctggtgtcca cagggccccc atccccatcc gtagttcccc agtccctgtg 60aggcactgac ccagccagaa ctctccagag atgttcccaa aaccatgggc atagtcctcc 120cagtccctcc agaagtctgt ctgtccatcc atgcggcgct ggaacacctg ggaagcaagt 180gggggcacca tcagcctctg gctcccgggg caacagaccc tgccctgcac agacccctgg 240gcttcccaat gccacccacc agccagccgc ccccatcagt ctccatgtcg caaaacacgw 300tcaggggccg ctcgcggttg ccgttgagga agatggtgct ggtcctggag gcaccggctc 360cgttctgcat ctcctccccg cagtccctgg ggaaggggat ccgcagccca cctgggagag 420gagagcaggg gccagtcctt ttccaagcct taggccctgg ctgcccaccc agcccccggc 480cccgggcccg tgcgtccagg tacccgtggt gaaagaggtg gacacgggcg gcaggaggct 540ctggccccac atggcctgga gccgtgcatt gtaggaggtg gagggaaaga ggccaagga 599436599DNAHomo sapiens 436gtctcagttg ccttctggag gtttctaaca gtgcagctct gccagcagta caggccgggg 60gctcggggat acctcaccgg ctcttattcc aagagtcact gaacggcgaa cacaaagctg 120ccccagccct cagcctgctc tggaggggca catttgatgt atgacctctg ttgacagcac 180cagcaaagca agttgccctt aaacccttaa actctgtatc cccctatatt acctttcagc 240cccacaagag gatgtggacg agacccccag ccctacagaa ccaggcacag aggccccagr 300gccccccgag gagcctctcc tgggggagct gacagtgaca ggatcctccc ctgactcgct 360gagcctttcc tggaccgtcc cccagggccg ctttgactcc ttcaccgtgc agtacaagga 420cagggacggg cggccccagg cggtgcgtgt tgggggccag gagagcaagg tcactgtgag 480gggcctggag cctgggcgca agtacaagat gcacctgtac ggcctccacg aggggcggcg 540cctgggcccg gtgtctgccg tgggcgtcac aggtgagtga gtgtgggtgg ggcagggtt 599437599DNAHomo sapiens 437atggaagaac tcacgatggg gttattcatg acagcagatg tgtcaggaac acaaatgacc 60cgtagaagat gattaatttt gttatagtgc tttcaccgca acgcatcaaa taaccattga 120aacgatgatg aatgctggtt gtgtagccgt gaggtgaatg attacaatgt acttgtgtac 180aaaaaaggaa gtgccaagaa ctttatgaac actgattgca actttaaaac acgctctgca 240tgcaaaatac aggaagggaa tgtgcactac acacattgtt attaatgccg gcagctgggr 300gagaaagtag gactatgaga ttcttgtttt ctgtttttca agctttccac ataatgttgc 360tgtattattt tcactagaaa aacgtgggct aaaaaagaaa ttctgggctg ggagcagtgg 420ttcacgcctg taatcctagc attttgggag gccgaggcgg gtggatcacc tgaggttggg 480aattcgagtc tagcttggcc aatatcatga aacccggtct ctactgaaaa tacaaaaatt 540agccaggcgt ggtggcatgc acctgtaatc ccagctactc aggaggctga ggcaggaca 599438599DNAHomo sapiens 438tgagattaca ggcctgagcc accacacccg gccctggttg gtgttcttat aaagcatcaa 60ttctgtcctg caaaacaaat ttgcttggca gctcctaagg gtcccaggcc tgcacactga 120gcatcacagg gatgccacct gagcatcatg acttcaccac aggtgtggtg ttaactgaac 180attcaaagca gaaaaatgat attctaagct tggggcacca gcatccagac tgtgggccct 240tggtgtgtct aagagaatcc cagagtccct tggttaaaag gaggcccacc aggcatgccy 300acccattcta ttttctgatg cagccccagg aaaggatgaa gaaatggccc cagcctcgac 360agaacctccc acccctgaac cccccatcaa gcctcgcctg gaggagctga ccgtgacaga 420tgcgacccct gactccctca gcctgtcctg gacggttccc gagggacagt ttgaccactt 480cctggtccag tacaagaatg gggatgggca gcccaaggca acacgggtgc caggacatga 540ggacagggtc accatctccg gcctggagcc agacaacaag tacaagatga acctgtacg 599439599DNAHomo sapiens 439ccaaagtctc ggagtgaagg caccagcaga accattccca ggagcttggg aggcttggtc 60tcagggaaag taaaataaag ccaccagata ctgacaataa aagggaaact gagtctagtt 120cagggcaggg cccagtgccc tactgcacac tcaccagtta aaccaacagc agacacgggg 180cccacgcgct ggccaccgtg gaagccgtac aggttcatct tgtacttgtg gtctggctcc 240aggcccgaga tggtgacccc atcctcgtgt cccggcaccc gcaccgcctt gggctgcccr 300tccccattct taaactggac caagaaatgg tcaaactggc cctcggggac tgtccaggag 360aggctgaggg agtcggaggt gatgtctctc actgtcatct gccctaggcg cagctttgca 420agaggagcat caggggactc ctcttcgggg gctaggaaga gatagaaaca gaatcttttc 480tcttgctgca aggaggtgtt gaggccccag ctgtcttgaa ttcaggtcag aaggtgggcc 540cagtctggcc ctaacttaag atcgatttct gattataatc ataatcagat tttgtggct 599440599DNAHomo sapiens 440tcgtgtcccg gcacccgcac cgccttgggc tgcccgtccc cattcttaaa ctggaccaag 60aaatggtcaa actggccctc ggggactgtc caggagaggc tgagggagtc ggaggtgatg 120tctctcactg tcatctgccc taggcgcagc tttgcaagag gagcatcagg ggactcctct 180tcgggggcta ggaagagata gaaacagaat cttttctctt gctgcaagga ggtgttgagg 240ccccagctgt cttgaattca ggtcagaagg tgggcccagt ctggccctaa cttaagatcr 300atttctgatt ataatcataa tcagattttg tggcttcctt atggtccctc aaccatgcca 360ggcagcctcc tacctcagta cttttacaat gactgttccc tctacctaaa tgttctttcc 420ccagatatct tcatggctca tccccacact tcctttaagt ctttgttcaa aagccacctt 480cttctgtggg ccttccctga ttactctatt taaaatttca gttttctcaa ttgcaatgta 540tcctccttct atagacctga tttcagcaac aaattgggaa acaacaatta tgagacact 599441599DNAHomo sapiens 441attgggaacc agaggagccc agcccagctg tgcccctttc cgagggttca gtccaagccc 60tcccctgccc ctgggggctc cctattgcca gaaaacttgc aataacaatg tcgtcagcgt 120cctcaccgtc caggaaggca gcaggccagc tccttctcaa gccctgggat ggctcctcag 180gcagacacca gatcccttcc ctgcctgagc tccccggcat catccccctc aacattctca 240caggcagccc acgctccttc accaggccca gtgggagcct tagttctccc gggccagccr 300gtgcagaata agaaagggaa cggagaaggg tgagaactac ctgtgtcgta acatcctgcc 360tccctgacct gccgagtgcc cccatcaggg atcctgcgct cctcggggcc ggccaaatca 420cccctttcct caggggccgg ccaaatcacg gccaaatcgt gtgctcctgg gtaagaggag 480atagagaccc agtctgtaag aagctgcacc ctgctgggga agcagtctgt gagaggcgga 540aagaggctgg acagaaaggg gagtaagatg aggcagggag ctagggaatc tcttttcct 599442599DNAHomo sapiens 442ggcctggcag ccatgactca ccagtcttgg ccaccacaga ctcgggcccc acacgctgcc 60tgccacgaag cccgtagagg ttcatcttat acttccggtc gggatccagg ccggggacag 120taacctcatt ctcatccccc gcaacaggca ctgcctgggg ctgcccctgt gcatccttgt 180actggaccat gaatgagtcg aaggggccct gggccactgt ccatgagaga cgcaaggagt 240ctggggtcac gccggtcact gtcagttccc ccaggagggg ctgctccagg aactcagggy 300gggggggctc ctctttcctc tctggagctg taaacaagga gatccagcca ggtgctgaac 360tggcagcctg ggactggggc ttggggtttc gacgggatgt cacacctatg gggggtgggg 420ggtcactagt ccattaattc gagtgctaaa cttctgggaa gcctgacaca gccagggtat 480gacacacctt ctgggccacg gggagctgct gcttgggatg gaaggggccc agcagtgcgg 540gggagtctgg ctgcccctca gccctggagt ggggccggga agctggagtc agctgtctt 599443599DNAHomo sapiens 443gggctgagaa ggggtcacat gggggctgag gtggctgcta ctcaccagtg gtgccatcgg 60ccgtgagggg gccataccgc ttcttgttcg caattccaaa cagagtgaat ctgtacttgt 120ggtcagggtc cagtgaggag acaacaaatg aacgctcggg cccttccaca ggtaccacct 180ggggccgtcc atccctgtcc ctgtactgga ccatgaaggt gtcaaactgg ccctcaggga 240cagtccagga gaggtgcagt gaatctgggg tagggtctgt cacccacagg tttcccaggy 300ggggtggagt ccctggactt gggtcactct gaggcactag gaagagtggg tagagagaag 360ggagagactt aggtccaagg agaatgggga agccaaatcc cacataggaa tgctgtgtga 420ggctgtgcag gttgttcact gcacaaaagt gcatttgctg agggagtaca gagggactga 480aatccagcca gcactctgct tgccgagctg tgtgccctgg tgaggagtgg tgtccacttt 540aaggaatggg tgccttcttt caaacggcat ggaagcactg cgtggactag tgtggctct 599444599DNAHomo sapiens 444acccattctc ttgggcagag gtgccaacca ttgagggcat gaggatgcat ctcttggagg 60agacaacagt tcggacagag tggaccccgg ctcctggccc cgtggatgcc tatgaaattc 120agttcatccc cacggtgaga gagatgccag gctccaggag gggactgagt gggcaggaca 180ggggggcagg gctcacctcc tggaggaagt tccaggtgat cattggttga gtccagatgg 240ctgggtacct gaagctgctg taaaggcttt cttagcctgc ttgacactgg gcactgaggy 300ctctgcagca tctccagcaa gcattggtcc cacacagttg gaacacctgg taacagagag 360ctcagtactt cctgaggctg tccagtccat tgttggtcat cactgttagc tgttatcatt 420gttgcagaat ccgtctgccc ctattctagc acctgtccgt tggccctagc tgggtattca 480tcagcagctg gaatgttttt tgctttccct gtgtcctaca ccacaggcct tcaggtattt 540ggagacacca gcctgatgtc ttcattcctc aggcaaaacc tcccagtttc ttcgcccct 599445599DNAHomo sapiens 445gtcacattgg accgtgaaga gaaggggcct gctctggctg tgctcagcag caccaggaga 60accaggctgg aggttagagc atactgggct ggcatcattc aggaggctgc agggagaaag 120ggtaggtatg agagcagctt caaaaaggag acaaaatgaa tccccccttc tccagcacat 180acccacggtc ccaccaccca caagtaatct acccaactca catgcatgta aaaattcaca 240ttccgcccaa ccctaaagga taccctccct gggcaagtct gttctctacc tctctgatay 300catttattta ccctgctcct cacccccttt tctattgtgt tcccctacac tggttttttt 360gttttgtttt gttttgtttt gttttgtttg tttgtttgag acggagtttc actcttattg 420cccaggctgg agtgcagtgg tgcgatctca gctcaccaca acctccgcct cccaggtcca 480agcgattctc ctgcctcagc ctcctgagta gctgggatta caggcatgcc ccaccatgcc 540tggctaattt tgtactttta gtagagaccg ggtttctcca tgtcggtcag gctggtctc 599446599DNAHomo sapiens 446aggctggtct cagactccta acctcaggtg atctgctcgc ctcagcctcc caaagtgctg 60ggattacagg catgagccac cgcacccggc tctacactgg tcttttgttt ttcccacgag 120cactacaagc tctcactact ccaagggcct ttgcattgtg tgttccctat gtctgggatg 180ctcttcactc tgctcataaa ggctggctcc atcttcaaat cttaactccc agttagggca 240gtcttccatt actctctatc acaatatcct gttcctgttc ttcatggcat ttactgctgy 300ctgagttatc agtttactta ttacctttct ctcaatgcta caatgggagc tccttgagaa 360caaggacctc atctatccca ggactgctgt atacttgtgt ctggcacata aatgttctat 420ctgacacatc aatgttgaat gaattagtgg atgagtacct agggccaatc cttccccaaa 480cacctggatc ccagctccta ctgtcttcta agaaaagtgc agattatctt ctccctctct 540ctctcacttt tttttttttt tttgagatgg aatcttactc tgtcgcccag gctggagtg 599447599DNAHomo sapiens 447ccccagccct tctctcagcc tggagtgtag ccttgggtaa gagatgggct ctgaccgacc 60ctcaaatcct gtcactttgt gtctaaggcc atgctaatca ctcccacacc ctgggaatgc 120ttgcacaaag atgtgtacac atgtacactt acaaatatat taatgtgtgc tcatccacaa 180gtacaaacat acctgcacag acacacaaat ccacccccaa aacctgcatc cttgtaggta 240cacatatggg tgcccatgca cacacgtgca cacacaccca atctcccctt caggtttccy 300ccacacctag tcattgggtg atgcctaaga aggctgattt cttgttggct ccgagggcag 360ctctgtgagt gaaagaacct ggatggtgtg agaggaacaa agcaggaggc ccttcccagt 420gggaagcagc ggacacatgg cctccaccat acttccccgt acccctggag gcctctgtga 480gttgtccagt gcccctcccc aaataagtgg attcctcatc tttccctgca cagtggggga 540aagcagagag ggtctttgca ccaggaagga gtgaagagag ctcaccagct tttctggaa 599448599DNAHomo sapiens 448tgcaggacca gaaactgcct tcctgtctct cattgcaccc ctaaccattt tcagctgggg 60cctggaaatc ctttctctta atttttccat tcccaggccg attagctccc cagaataagg 120ggtatctgga ttccccaacc tacccctccc tgacacctcc ttcctacctg gttccagccc 180aatatctgag acccccacat tcccttttta gtctcactcc tagaatcctt ctaccttcac 240ctctcattgc cagattcaac tgagggtgta gcaggagggt cagagggagg catgggggcr 300ggaccagaac ccccatctgt ggaacatctt ttatggaagc cagcccctct ccccacccct 360tgggacctat acagtcccta atgagcaaag tgtcaaagtt ggctacaaca caaaataccc 420aggaagctga gtcacagttt gggaagatgc ccccatccct gccagccctc caactgtggg 480gagggtgcca agagggtgag gccatatctc tctccaaaca cacactacag agaaccaccc 540cagacatagt ggcaggggga atggtgaagg ggagacacaa gagacaccca attctttgc 599449599DNAHomo sapiens 449caggctccct gtgaaggagt gtctgggagg agagggtggt atgtgtgtgt tggggtgggc 60agtatgtgtc agggtttgga tgggatgcag acaactgaga ggggctggga acaaaccgag 120ggactccggg agtcagatgg tggaaccagg gtagaggtgg ttattggtga ggtgagcccc 180tgggccctgg aggtgctggg gctagcggga agataggact aggctgaact ggtggccagc 240tgaaccttgg aaggaaagtg cttgcggaat cccaaatgtc gggctagagc agctgagccy 300aggctctggg ggctccaggc tccaggaggt gccagagggt gcttctttgg gcatccaaat 360ggggactccc taggtggcag cgtgagagtt gcagggaggg aggtctggga gatctcttta 420ggaaatactg aaatgggaca gtcaggactc gggtctggga cgtgcacaga gcctgcagag 480aggatcctaa aacttgttct tggccagagc tctgcactca tgactcacgg ttcagcaggg 540ctgggatggc tgagagatgc ctctgggggc acaggggctc cgtcttcact ctgtgcccc 599450599DNAHomo sapiens 450ccaggtggcc aggtgggact gtttcaaatt tccctgatcc ccaggcttgg ggcaattggt 60aaaggaaaga gcaggtgtgg gggttaagca cttatttgag gtgggggtgt tcacctctct 120tctcatccct tttcagaata tagggctcct ctcattcctg tgaaccccca gtcctggctt 180ctttgtttga ggggattgtg tgaggttcag ttgtggggtg ggtggtgagc tgctgcatat 240tttttatttt gtttctctag tgttatggca gtggaggtgg gaatttagtc cccaggtggr 300acaagggaag ttttttcatt ttggagctag ttactgggag taagggaggg tggggtgggg 360gggagttcag gtttatgtgt gtgcatttct tttttattat tattaaataa acaacttgga 420gggagttgaa ggaatggtgg ctgccttcct ggctcgtgat ggggagtttg ggggaaagtg 480gcttttccag agccagcatc aaagaatcaa gcactgaaga catagctggc tctgaggtgg 540ggtgggtgcg ggatcacaga ccgcatgtca tccccttgcc cccacccctg caactctgg 599451599DNAHomo sapiens 451tctcgtcctt tcccattctt ctgagaccca ggcccctagt cctgaaagtc cccagttttg 60ctttcctcca aaaatctgct ccagcttccc cgttccaccc acatataatt tagaactata 120aattccacaa ttccctgcgg ttaaggtagc cgcgccaact acggacaccc ggtcgggtca 180ataagtacct gcgcggccaa agtgcctagc atggtgacag gaggagccgg gccattcgaa 240tcacctctcc ttccaaagct aaatggctac tgaatgctgc cctcggagcc ttgccccacr 300cggagagggc agccggagag gggcgcggtg cgggaggcgg gggtaggggg cggaacaact 360gggaaagata ctgacaacta accctggagc ccgcgagact ccgaatctag tcaaattcct 420ggcagccaat cgggagaagg gaggaatctg gttagcccgc ctattgaacg tgacatcatt 480tcctccgcaa ccatgaagct ccaggcctta gcaactgaac taggccagag caaccgaact 540aggcagaatc gaacagaatt tggcgcggtc gggctggcca ggctgctcaa gagtcaaag 599452599DNAHomo sapiens 452aatacaaaaa ttaggctggt gtggaggtgt gtgcctgtag tctcagctac ttaggaggct 60gaggcaggag aatcgcttga acccgggagg cagaggttgc agtgagccga gatcacacca 120ctgcacttca gcctggcgac aaagtcgcct tatccaattt cctttccttt cctgaggtag 180aaaggaattt gagaaattct gtctcaaaat aataatttgt aaaaaaagaa ataagaaaga 240gtataggctc tcccccaaag tgtagatact acatgcttgt tgactgactc acactatcty 300cctcaagtct aattgtgcca gagctcagct ctttggaggc agtcatcaag gaatcaagac 360gaaagagagc cacaaaccag gaagattata tccttaagcc tggctagaga acaagacatt 420tgagaaagat acataaagag gatgacaagt gaaatttgct tatctgttgg gatagatgct 480tggactggaa agtggggaaa cagcaatgtc tctctcctct ccctttcccc taaagatttg 540agaatgaaat ggaagatgag caggcatgag aggaagagat gaaaaggaat cttcttccc 599453599DNAHomo sapiens 453ctcccaaagt gctgggatta caggcgtgag ccactgcgcc cagccaagaa atctttactg 60agggcctcct ttgtaccaag cactgtgcta catgctggga ataaggcagt ggaaaaagcc 120ttggatctct ggtaacttac attgaattga agatgacaga cgataaaaaa atcaataaaa 180tttaatacaa tgtcaggcac taacaagtgc tatgaacacc atgaagcagg gtgaggggta 240agggaatggg atagaaagtg ctcccaggta tgcatggtgc tatatttatt gatgatgatk 300attattatta tttatagagt cttgctctgt tgcccaagct ggagtgcagt agtgtggtca 360tggctcaccg cagccttgac ctcctgggct taagtgatcc tcccaccgca gcctcatgag 420tagctgggac tgcaggttca tgccaccatg tctggctaat tttttttttt ttttttagag 480acgaggtttc actatgttgc ctgggctggt ctcaatctcc aggcctcaag caatcctcct 540gcctctgcct cccaaagtgc tgagattata agcaagagcc actgtgcctg gccatggta 599454599DNAHomo sapiens 454aatctaaccc agaggaaaga gagacacctt tttgctacag tgagggatga attgatccgg 60actttgaaag atattgtaaa taaaatttga ccaagtagag aggcagatgt caagaggggg 120agaacatcat gagcaagagc ctagatgtgg tctaaagcct ctgaaatttg tgacaagctg 180caaacaattt ggtttataat aggcagagat ttgggaagga ggtctaagat ttgggaacag 240ctgggcaaat acctggaggt gggaatgatg agtaattcag tatggttaga aattagaatr 300aacagagaag ctggatgatt ttaaattatg gaaggtgtta aaggccagat taaaattttg 360taaataattg agtaggcaat agggaacctt gaagggcttt tgagcagtgg agttatgaaa 420gtgtgtttag ggaggctgat ctgacaatag tgtggaggga gacttgaggt agggagaagt 480aggaagtagg gagacctgtt gggaaagctg atgcaataat cctaatgagg taatttttcc 540agcaagggct ggggaaaaat tacagattca aaagacattg tggtggcaga actgactag 599455599DNAHomo sapiens 455tctctctgtt tacaaggtca ttgcttggtc taaatttgtc tcaatcaaaa catttttgcg 60ctcagaatgg tgtagagtga cgatgaggtg gcggtaaggg gttgagcgct cacgcgaacg 120cctaagtgac cagaacgact ggtgtgaagc cgtgatctga ctctgtggag cctgggactg 180gtttcagcga gagcctctgt actgctctgt agtctctgct aggacatgga cgaaaaggga 240cgcagccggg agagcgactg ccccaggtgg gggctggggg gacgtaaggg aagaataatr 300attatctggc tgtgtttttg tttaaaaaaa aaaaaaaact ggtgtaaatc tccatagact 360tcctatcctc gctcccttca cccacccacg cgctcccaag atgcaataag caaataaaaa 420gactaataac gctgtactgc aggtcgactc aggagctgga gatgcgtctt ggtgggaggt 480ggtgggtggg agtagggggg tttagggaat ggatctgaac attgaccagc ccagagactc 540taagcagcct caaaagcaaa gggaaagtgg gggaacaagc acacattacc aacagagct 599456599DNAHomo sapiens 456gcctgtaatc ccaacacttt gggaggccga agcaggcgga tcacaaggtc aggagatcga 60gaccatcctg gctaacacag tgaaaccccg tctctaccag aaatactaaa aattagccag 120gcatggtggt gggcacctgt agtcccagcc acttgggagg tgaggcagga gaatggcttg 180aacccaggag gcggaggttg cagtgagccg agattgtgct attacactct agcctgggcg 240acaagaacaa aactctgtct caaaaaaaaa aaaaaggaag aaacagtgac ttggaacatk 300aaaaatgtta tataaccatg agctatcact gtcattcata gggttgtggt agatgtgaaa 360tgacatgatg tacataaaac tcatcactta ctattatatt

attacaatat tttaagagat 420gtcctgcctt cactgaaaac tgtccagtgc cttcccatct cactcagaat ttaaaaaaaa 480aaatcaaaag cctggttacc gggactgtcg ggaaataggg atgaggatat atatatatat 540atatatattt tttttttttt ttttttgaga tggagtttcg ctcttgttgc ccaggctgg 599457599DNAHomo sapiens 457ccgcaactca tgcccaccct aaggctctga gtaaacccca ctctttcccc atttgaaatt 60ctctccccac ttgccttcct ctctctctcc attcccacct ggcttctttc tcctgggagg 120cttcaagcag accagcctca gcagaagcag ctcagactgg tgggtgggcc tggcaggcta 180agaaggagag gaggggctgg gccagagagt cctcccattc ctgccccctc ccacaagcct 240cctccttagc tccagcaggg tcagctcagt agggtcaagt cccactaccc tcatccccay 300cccagcaaag ggctccctag aagtatcttt ccaaccctct gaggccccta tttctggact 360ccccagatca gaagctatga gctctgtaac accaccagta cccccttgaa cccaaaacag 420actaggggag agttaggggg cagggagaga accagctgca gggaacaaag cagttcaggt 480tatgggagaa aaagcaagat cagctgagga aagctagaag ggcaagtcgt cacaaagggg 540caggggggca gcccagggca ccaaggggaa aactgccccc ctctcttcat gacatttgt 599458599DNAHomo sapiens 458ggtgcagtct ccactcttga cccccacctc ctactgtctt gtctgtggga cagttgcctc 60cccctcatct ccagtgactc agcctacaca agggagggga acattccatc cccagtggag 120tctcttccta tgtggtcttc tctacccctc taccccacat tggccagtgg actcatccat 180tctttggaac aaatcccccc cactccaaag tccatggatt caatggactc atccatttgt 240gaggaggact tctcgccctc tggctggaag ctgatacctg aagcactccc aggctcatcm 300tgggagcttt cctcagcacc ttcaccttcc ctcccagtgt agcctcctgt cagtgggggc 360tggacccttc taattcagag gtctcatgcc tgcccttgcc cagatgccca gggtcgtgca 420ctctctggga taccagttca gtctccacat ttctggtttt ctgtccccat agtacagttc 480ttcagtggac atgaccccac ccagccccct gcagccctgc tgcaccatct caccagacac 540aaggggaaga agcagacatc aggtgctgca ctcacttctg ccccctgggg agttgggga 599459599DNAHomo sapiens 459ctccatgctc actgttttcc gggaaatctc cactgatggc cggggtggtg gtgactatct 60gaagaagcct gggggcggtg ggtgaaccct ggctctgagc tctcctccca tctgtcccca 120tcttcctccc cacacctacc cacccagtgg gccctgaagc agggccaaac cctcttcctt 180gtctcccctc tccccactta ttctcctctt tggaatcttc aacttctgaa gtgaatgtgg 240atacagcgcc actcctgccc cctcttggcc ccatccatgg actcttgcct cggtgcagty 300tccactcttg acccccacct cctactgtct tgtctgtggg acagttgcct ccccctcatc 360tccagtgact cagcctacac aagggagggg aacattccat ccccagtgga gtctcttcct 420atgtggtctt ctctacccct ctaccccaca ttggccagtg gactcatcca ttctttggaa 480caaatccccc ccactccaaa gtccatggat tcaatggact catccatttg tgaggaggac 540ttctcgccct ctggctggaa gctgatacct gaagcactcc caggctcatc atgggagct 599460599DNAHomo sapiens 460gctacacgct gtcgcctggc caaggagggc tttattcgtc tgagtagttg tcagtcataa 60ccaaagccat aagcaatttg ctcgggacta cctatagacc tcgcccacta taagcccctt 120tctttccttc gcttcctctt ttagagaatg tccggattgc tattggactt tggagcgtat 180ggctccaaat caactcattg gctaaaactt gacggaaaat ggtggttagg taaaacgcgc 240ctgcgcagca cgcggcggga cgggggtggg ccaatcctgt gagggtttaa ccttctcttk 300ttccacctct tcacccctat cttgtcgcca tggtgactgc tctacaattg gcgaggcttg 360cacttcaaag tcctaggctc gcttcatccg ggtccttcag ctgtggactt tctgctgatt 420gggccttttc cttttcccct gattggccga catcgggaaa gacggcgaag agctaggaaa 480agagggaaaa cactagggtc gcagggttca aaatggctcc aacctccttt ggtgacgtag 540agagcagaac ttgggtctgc ccctcccttt tagttaaggg agcagaactg ggattagcc 599461599DNAHomo sapiens 461ggccggacag aagcttggaa ggtcctgtct ccccagggag gaggcccctg ggacagtgtg 60gctcgtgtcc ttcccaacgg ctccctcttc cttccggctg tcgggatcca ggatgagggg 120attttccggt gccaggcaat gaacaggaat ggaaaggaga ccaagtccaa ctaccgagtc 180cgtgtctacc gtaagaattc cagggtcttc tccaaggcct ccctcttacc taagaaaaag 240ccttcaaccc cagccttggc ccatgagggc ctctgacttc cactggcctc atttccacay 300acagagtttg agaaccttca caattacagc ctctgactgg atttttcctc cttcagagat 360tcctgggaag ccagaaattg tagattctgc ctctgaactc acggctggtg ttcccaataa 420ggtagtggaa gaaagcagga gaagtagaaa acggccctgt gaacaggagg cgagtgtgtg 480tgggtgtggg tgtgtggcat ctctcatttt caaaggattc tgaggtcacc actctttccc 540caggtgggga catgtgtgtc agagggaagc taccctgcag ggactcttag ctggcactt 599462599DNAHomo sapiens 462ggggaacccc tcccattaaa gatccgggca ggactgggga caggttggaa gtgtgatggg 60tgggggggtg ggaggcatgg gccgggggca gttctctcct cacttgtaaa cttgtgtagt 120ttcacagaaa aaaaacaaaa tgcagtttta aataaagaaa tttctttttt ccctgggttt 180agttgagaat ttttttcaaa aaacatgaga aaccccagaa aaaaaatgat tttctttcac 240gaagttccaa acaggtttct ctcctgttcc ccagccttgc cttcatgatg caggcccaaw 300tgcacccttg cagacaacag tctggcctga accctattga tgcaactttg cgcaatcaag 360atggggctcc agtgggtcac caggcagccc tgatggactg atggaataaa taggatcggg 420ggctctgagg gaatgagacc ctagagggta cactccccat cccccaggga agtgactgta 480cccagaggct ggtagtaccc aggggtgggg tgataattat ttctctagta cctgaaggac 540tcttgtccca aaggcatgaa ttcctagcat tccctgtgac aagacgactg aaagatggg 599463599DNAHomo sapiens 463cttgaggctg gagccaaccc caaccagcca gaccgggcag ggcgcacacc ccttcatgct 60gctgtggctg ctgatgctcg ggaggtctgc caggttagca cacactgagg tccctacagg 120gaatggggcg agcttacaag taaagctgga cagaagcatc ccctagagtt tgacaaggag 180gaaattggtg tgattgggaa cctgacaggg aaactgcgga ggatggctga atatggattg 240cgagtggggt taatagtgta aggaactcga gttggcagtc caaggtaccc caggggtcas 300tggccctctg tctccccagc ttctgctccg tagcagacaa actgcagtgg acgctcgcac 360agaggacggg accacaccct tgatgctggc tgccaggctg gcggtggaag acctggttga 420agaactgatt gcagcccaag cagacgtggg ggccagagat aaatggggta tgtagaggaa 480ggggtgatgt atgctataga gaagttgagc agatggggtg ggagatagcg tgcaaaatat 540aggtgcagca gaggggcatt ccctctcatc ctgctgttac ggcggtcaat ctgagatgc 599464599DNAHomo sapiens 464gcctccttga ggctggagcc aaccccaacc agccagaccg ggcagggcgc acaccccttc 60atgctgctgt ggctgctgat gctcgggagg tctgccaggt tagcacacac tgaggtccct 120acagggaatg gggcgagctt acaagtaaag ctggacagaa gcatccccta gagtttgaca 180aggaggaaat tggtgtgatt gggaacctga cagggaaact gcggaggatg gctgaatatg 240gattgcgagt ggggttaata gtgtaaggaa ctcgagttgg cagtccaagg taccccaggk 300gtcactggcc ctctgtctcc ccagcttctg ctccgtagca gacaaactgc agtggacgct 360cgcacagagg acgggaccac acccttgatg ctggctgcca ggctggcggt ggaagacctg 420gttgaagaac tgattgcagc ccaagcagac gtgggggcca gagataaatg gggtatgtag 480aggaaggggt gatgtatgct atagagaagt tgagcagatg gggtgggaga tagcgtgcaa 540aatataggtg cagcagaggg gcattccctc tcatcctgct gttacggcgg tcaatctga 599465599DNAHomo sapiens 465ggctcaggac atcccaacca tgccccttgg aaggtcccgg actgtacttc cccacagcaa 60actgctgaca tcaggggtgt caccccatct gttggtaaga cagagtaatg ggtcaatcta 120aaggacacaa caagggggaa gggacaacat gtaagctcag agagaatcaa aacctgaggt 180gttgggaagc taagttctgg ctctgtgtgg ctttagccaa gtgacttttc tgcttttctc 240tgacttcagt ttcttcctct gtaaaaggaa cctgcagctt aattctctga cattccaggr 300cagtggtttt ctcttttttt tttttttttt tctgagacgg agtctcgccc tgtcacccag 360gctggagtgc agtggcgcga tctcggctca ctgcaagctc ctcctcccag gttcacgcca 420ttctcctgcc ttagcctcca gagcagctgg gactacaggc tcccgccacc acgcccggct 480aattttttgt atttttagta gagacggggt ttcactgtgt tagccaggat ggtctcgatc 540tcctgacctt gtgatccacc cgccttggcc tcccaaagtg ctgggattac aggcgtgag 599466599DNAHomo sapiens 466ggactgtggg gtaaggagag ggggactcag gacctcccta aaacctgact cttttcttca 60ccctagaaag aattccccat attttgtgcc ctctagggct ttggttgcta agtgggggca 120gctgtggagc aatgagctta gtcaagtcct ggatggtagt ccagacaccc caatgtctgc 180taacacccct gtctccctag actgtcccct ctctgtaccc tcccaagctc tcctctgttt 240ctaaaggaga gtcccaggcc cttttccctc tgtgaggtgc tgactgctag gggaaatacy 300ccatggcagc aaggcttagg gaaggaggct tgagacctga gttccttcaa ctcttagaga 360ggagcccaaa ggccacgccc cacattaaat actgatgcca ccccattacc ctaggttgga 420gtccagagtc ttcgacccct gtttagtgat ggttattagg gtggaaactc cctggagccc 480aaggctgtgg ccacactgta actcagagcc atctacgtcc ttcctcctcc tctcacccac 540ccctctcctt ccctggctcc agtggatttc aggctcacgt gcaggctgga ggggtctca 599467599DNAHomo sapiens 467ccagcctgga caacaagagc gaaactctgt ctcaaaaata ataataataa taatataata 60gcattctatt aactgtttag tcttctagga cttgcactgt aatgccacag tccatcaggt 120tgttgcacac agctgtgctt catccatttt caacagaatg taatatgtca ttgtgtgaaa 180ttaccacagg acatggtttc aacatccaca aaatgattaa cttgatgctc tctgaggcgc 240cttttagata tgagaatcta ggaccctctg caccgtctta acccaagagt ttgcttgatr 300gagagcggga agaataatgc aagttgcatc tccaatatct cccctcccct ccacagggtt 360ttgaaggccc cacctgcagc cacagggccc cttcctgcgg cttccatcac tgccaccacg 420gaggcctgtg tctgccctcc cctaagccag gcttcccacc acgctgtgcc tgcctcagtg 480gctatggggg tcctgactgc ctgaccccac cagctcctaa aggctgtggc cctccctccc 540catgcctata caatggcagc tgctcagaga ccacgggctt ggggggccca ggctttcga 599468599DNAHomo sapiens 468ccacaggcac tgcagcctgc cactctctgg ccaatgcctt ctactgccag tgtctgcctg 60gacacacagg tgaggcccca agacaagggg cacaagtgtg tctggagcac agccaagcag 120accatggaga gccagatagt ctccacccat gcggcagccg tcacctggtc catcccctgc 180ctccacgccc acccccgccc agaaaagatg ccccaggatc ccttcacctg cacatctagc 240actgggccaa catccaggaa tgagctagga tggaggcagt gactgatgca gtgtgtgacr 300tctaatctcc cccataatta caggccagtg gtgtgaggtg gagatagacc cctgccacag 360ccaaccctgc tttcatggag ggacctgtga ggccacagca ggatcacccc tgggtttcat 420ctgccactgc cccaaggcaa gtgaccacaa atctgccttc tctgttgccc cctatgctga 480caaggcaaga atacctcagt tggaatccca gaagggactg tgggtgagca ctgatgtgga 540aattattgga aaaagccatg ccaagctcac agtgggaagt gtctctcaga agcagtcaa 599469599DNAHomo sapiens 469agtgagccaa gattatgcca ctgcccttca gcctggggga tagagcgact ctgtctccaa 60aaacgagaga gaaaaaaaaa aagaaaccaa aaaactcaca tgtaccccat agatacgtat 120gactaccgtt tgtcaataac aaaagaaaat aaaatggcaa ccacacacac aaaaaagttg 180tggttctgag catatgaatc aggctgctta gacttgaatg ccagctttgc ctctcctggc 240ttagtgacct ggaccacaaa gaagaggccc taatccagcc tggggagaag ttagggacay 300cttcctgaag aagatgcctc ctgaacacca gcctgtggaa gaggggttgg gaaggccatt 360ccaggtagtg tcaatagcag ggataaaggc tgagaggcaa gaatcagtat ggggtacgtg 420gcaaagtcag cagcagtttc atgttgctgg agcagagagt agaagggtgg gatggggaga 480gctgaggcct gagaggcagg cagggctggg tcatgcaggc cttggacttt attcagaatg 540aggcgggcag cctccgaagg ttcagcaggg gagagacagg tcaactggac attttcagt 599470599DNAHomo sapiens 470cctgccccgt tcctgtgggc ttccacacag cttttggcca aaacaaccat ctgagaatca 60aaaccacaca gacaaatcag ttcttgattg cagaggtgtt gaattgtgca atcagagaag 120cctaacacaa ttcctgttac ctcatttaac gcaattcaag caacaccaac cagcccattc 180cacaggattc cagtttaacc caaccatgag ggacatgact caacgtggag caactcaact 240ctgtcctgat catcataacc caggcagagt ggaccacact taatccagct acactcaacr 300catttcaccc caccccactc acttcgatgt cacgccaccc tctttgtaaa agaacactaa 360aataaggttt gatatgagaa gagctcggga aagagattat gatggagtta agggatagct 420gatgggaatc acagggagag aacattaaag gaatgcagaa ctcaggggac agacttaagc 480cacttgtcct cacttgaggc ataccttgaa ttatttcttg ctcaagcctt gctttaagcc 540aagaaaacag ttgctttaac attatgataa gctttagggg tatgtctcca atattctgg 599471599DNAHomo sapiens 471ccagtgtaaa tggtgtgatt gcggcttggg agcagaggac ggggctcaaa gaaaaggcat 60tcacttgctt atttagcaag cacttaccaa ctgcctacta tgccagatac ggaggcaaat 120ctgagtaaga cagttgccat cttcatgtga ctttaagtct aatacagaga gaccaacaag 180tctcctgttg atcatagccc acagaggtgc tctgagagaa aaacgtgcag gatattacaa 240gagcacagag gaccagccaa cccagactaa aaatggagga ggtgatggct gagatgagty 300ttgaaagata agcagaggct gggcgtggtg gctcacgcct atagtcccag cacttcggga 360agccgaggcg ggtggatcac ccgagattag gagttcgaga tcagcctggc caacatggtg 420aaacctcgtc tctattaaaa atacaaaaat tacactttgg gaggccgagg cgggtggatc 480atgaggtcag gagatcgaca ctatcctggc taacacggtg aaaccccatc tcaactaaaa 540atacaaaaaa ataactgggc gtggtggcgg gcgcctatag tcccagctac tccagaggc 599472599DNAHomo sapiens 472gcagaagctc tccctgtgcc aatggtgggc agtgccagga ccagcctgga gccttccact 60gcaagtgtct cccaggtaaa ctggggcaca cactgtgggg gacagcggga gcaggaggca 120gacatccgtg caggtccctg accttcctgc tgtgccacag gctttgaagg gccacgctgt 180caaacagagg tggatgagtg cctgagtgac ccatgtcccg ttggagccag ctgccttgat 240cttccaggag ccttcttttg cctctgcccc tctggtttca caggttcaca ggggaggcay 300tggaaagaac tggcagaata ttttattcca tttgggttgg ggcagagttc attggtgggt 360gtttgatggt tgggatgtga gaatagaatg agaatggtat cctttaaagt tatttagtgt 420aaaacctgca caattgtaca accatgggga caagggcagg ggttaccgta gggcccacat 480gggcccagtg taaatggtgt gattgcggct tgggagcaga ggacggggct caaagaaaag 540gcattcactt gcttatttag caagcactta ccaactgcct actatgccag atacggagg 599473599DNAHomo sapiens 473ctgacttgcc ccactcaggc ggtcctcccc cgaggtgctg tctgcatggg gttgaataag 60atgaaccctg aggccctgct gcttcgcagt gtgtggccct gctccttgag gtgtgaaagg 120ccagggaaca gggtgcttgc tggggacctg cgggaggact acaaggcttt ctggtggcca 180ttcctgtgta tacagagggc ggggctcacc agggcaggct gatcagcctg gaggacctca 240aggtacaaat aggaacaaat tggcttggag aatgagtccc gcttcttgtt ctccctgggy 300gggcctccat gctagggaga acagagatcc caaagtggag gaatttgaag tgcatctggg 360aagcttgttg ctcctatatt tgtcccgttg ctttgggttc atcctggtct ccactgtttc 420atcctgaatt gaggtgggat caacctctgg accttggctt cctttctttt cttgcctgag 480gagtctgctt ctgaagctcc ttgatatcta caatgttgtc ccttgggtta ccgaaccgtt 540ttctcttatt tctctatgat tgtctgttgg gtgacctgag ccagtatctt tgggtgccg 599474599DNAHomo sapiens 474tttcttttct tgcctgagga gtctgcttct gaagctcctt gatatctaca atgttgtccc 60ttgggttacc gaaccgtttt ctcttatttc tctatgattg tctgttgggt gacctgagcc 120agtatctttg ggtgccgctc agtttagaaa gtcaatatgg ggtagtggtt ataattgttg 180aagcccttgg tttgaatctc agctctgcca cttgctagct gggtgacctt ggacaagtca 240cttaaactct ctgtgcctca gtttcttcag ttataaaatg ggcagtgctg acctcatagr 300gttattgtaa taagtagatg agacaatgcc tgtaagatgc tcagacagta cctggcataa 360agttggcgat tatttttctg atttcattca actccttgat gttggctctg ttgctgtctc 420cctggggcga cttttccccc ttaaaactag cctggaggtg ggtgctgtct tgcagcaatt 480tttttcttgt tgtaccaaat tttcctgttg tatcacaggg cttttgggat tttaagggat 540taccttgaat ctctacatgg gagagtttct ataatcagag ggagcattct gggttgacc 599475599DNAHomo sapiens 475agggttattg taataagtag atgagacaat gcctgtaaga tgctcagaca gtacctggca 60taaagttggc gattattttt ctgatttcat tcaactcctt gatgttggct ctgttgctgt 120ctccctgggg cgacttttcc cccttaaaac tagcctggag gtgggtgctg tcttgcagca 180atttttttct tgttgtacca aattttcctg ttgtatcaca gggcttttgg gattttaagg 240gattaccttg aatctctaca tgggagagtt tctataatca gagggagcat tctgggttgr 300cctgagcaaa ggctgcagca cagaaagttt atgaactgct cttctaccct ctcttgctgg 360gctgctgtgt acagtggacc aggttgtgca gcctctatga tgactatgaa atgaatggca 420gcttcccccc aagttgagga atgcataacc tcactaccat ctgtggtaac ccctctccta 480ggggtcttgg gtgtccctga gttttcgtct gggggtagag agagaagcat ctgtggtaac 540ttacgccaat tggcctgaag ctgtccttac tctggagggg gcattcctag tgggttcag 599476599DNAHomo sapiens 476aatttttttc ttgttgtacc aaattttcct gttgtatcac agggcttttg ggattttaag 60ggattacctt gaatctctac atgggagagt ttctataatc agagggagca ttctgggttg 120acctgagcaa aggctgcagc acagaaagtt tatgaactgc tcttctaccc tctcttgctg 180ggctgctgtg tacagtggac caggttgtgc agcctctatg atgactatga aatgaatggc 240agcttccccc caagttgagg aatgcataac ctcactacca tctgtggtaa cccctctccy 300aggggtcttg ggtgtccctg agttttcgtc tgggggtaga gagagaagca tctgtggtaa 360cttacgccaa ttggcctgaa gctgtcctta ctctggaggg ggcattccta gtgggttcag 420gactagttcc ctgttttccc cacccaaggc cccatccagc tgatacctgg cgggcagagg 480cagtggaagg tggcaagtag gtccagacag gtgcttcctg ggtggcaggg ctgggagagg 540cactcattgt gatcagcctc acaacgggag cctgtgtagc caggtggaca gaggcagtt 599477599DNAHomo sapiens 477gtgccatggg gatgcccaat gcagcaccaa ccccctcaca ggctccacac tctgcctgtg 60tcagcctggc tattcggggc ccacctgcca ccaggacctg gacgagtgtc tgatgggtga 120ggccactccc acttcagagc ctctctgagc ctcagacagg cctctgcact gaagacagaa 180aagggcagat tgcttttcca attaaaaaac caaacatctt tttccttgaa tttgcccaga 240tttggcatct cttgcctaca tgaccctctc tccaatgttc agcccctcag tccccatgar 300tttggtccct tatttccttt ccatcttaaa gacacaagcc ccttccccaa tttggtctcg 360tctgccacac gcaggccccc acaccttccc tgacagtctc acctccttgc ccttcctgcc 420ctgacccctg tggactccca gctcttctct cctcccagcc cagcaaggcc caagtccctg 480tgaacatggc ggttcctgcc tcaacactcc tggctccttc aactgcctct gtccacctgg 540ctacacaggc tcccgttgtg aggctgatca caatgagtgc ctctcccagc cctgccacc 599478599DNAHomo sapiens 478aaaagatgtt tggtttttta attggaaaag caatctgccc ttttctgtct tcagtgcaga 60ggcctgtctg aggctcagag aggctctgaa gtgggagtgg cctcacccat cagacactcg 120tccaggtcct ggtggcaggt gggccccgaa tagccaggct gacacaggca gagtgtggag 180cctgtgaggg ggttggtgct gcattgggca tccccatggc acggctggct cagacacatg 240tcttccaagt ggcacaggag tcctggaggg gtaagagggg gtgaggctct caaaggccay 300ttgaagctcc tagcagtcct cctggtgctt ctctcaccct ccttctctac ctcccacctc 360ctgataccct ctacccccat acctgtgcgt ccaggtgggc agaggcagga gaaagagccc 420acccggtcaa tgcaggtgga tcccggggca caggtggcag caatacagtc atccaggttc 480tcctcacagc ttgtgccgcc ccagccactc acacacacgc agtgaaagct accagcagag 540ttctggcagg tgcccccgtt tctgcagtga gggggaccct gggtctcaca ctcatccac 599479599DNAHomo sapiens 479aatgggggca cttgccagga tgggctggac acctacacct gcctctgccc agaaacctgg 60acaggtgagt tgtttaagcc acatccatga cacccatggc ccagagagtt ggcccctggc 120ctcccctact catagggctc ccagccttag ccctcgtccc ctccccaacc ccctgcaggc 180tgggactgct ccgaagatgt ggatgagtgt gagacccagg gtccccctca ctgcagaaac 240gggggcacct gccagaactc tgctggtagc tttcactgcg tgtgtgtgag tggctggggs 300ggcacaagct gtgaggagaa cctggatgac tgtattgctg ccacctgtgc cccgggatcc 360acctgcattg accgggtggg ctctttctcc tgcctctgcc cacctggacg cacaggtatg 420ggggtagagg gtatcaggag gtgggaggta gagaaggagg gtgagagaag caccaggagg 480actgctagga gcttcaagtg gcctttgaga gcctcacccc ctcttacccc tccaggactc 540ctgtgccact tggaagacat gtgtctgagc cagccgtgcc atggggatgc ccaatgcag 599480599DNAHomo sapiens 480cccacagctg atccatgacc ctgtcaggtt tcataggccc agactgtgag gtgaatccag 60acaactgtgt cagccaccag tgtcagaatg ggggcacttg ccaggatggg ctggacacct 120acacctgcct ctgcccagaa acctggacag gtgagttgtt taagccacat ccatgacacc 180catggcccag agagttggcc cctggcctcc cctactcata gggctcccag ccttagccct 240cgtcccctcc ccaaccccct gcaggctggg actgctccga agatgtggat gagtgtgagr 300cccagggtcc ccctcactgc agaaacgggg gcacctgcca

gaactctgct ggtagctttc 360actgcgtgtg tgtgagtggc tggggcggca caagctgtga ggagaacctg gatgactgta 420ttgctgccac ctgtgccccg ggatccacct gcattgaccg ggtgggctct ttctcctgcc 480tctgcccacc tggacgcaca ggtatggggg tagagggtat caggaggtgg gaggtagaga 540aggagggtga gagaagcacc aggaggactg ctaggagctt caagtggcct ttgagagcc 599481599DNAHomo sapiensmisc_feature(300)..(300)n is any nucleotide 481ttccagtgcc tctgccctgt ggggcaggag ggtccacgtt gtgagctgcg ggcaggaccc 60tgccctccta ggggctgttc gaatgggggc acctgccagc tgatgccaga gaaagactcc 120acctttcacc tctgcctctg tcccccaggt gtgtcctcac aggggctctc cggccgcccc 180tctctctggg cagggcagga tgtctccgtt ggagcctcct cccacagctg atccatgacc 240ctgtcaggtt tcataggccc agactgtgag gtgaatccag acaactgtgt cagccaccan 300tgtcagaatg ggggcacttg ccaggatggg ctggacacct acacctgcct ctgcccagaa 360acctggacag gtgagttgtt taagccacat ccatgacacc catggcccag agagttggcc 420cctggcctcc cctactcata gggctcccag ccttagccct cgtcccctcc ccaaccccct 480gcaggctggg actgctccga agatgtggat gagtgtgaga cccagggtcc ccctcactgc 540agaaacgggg gcacctgcca gaactctgct ggtagctttc actgcgtgtg tgtgagtgg 599482599DNAHomo sapiens 482ccccaaaggc acctcctgcc ataacaccct gggctccttc cagtgcctct gccctgtggg 60gcaggagggt ccacgttgtg agctgcgggc aggaccctgc cctcctaggg gctgttcgaa 120tgggggcacc tgccagctga tgccagagaa agactccacc tttcacctct gcctctgtcc 180cccaggtgtg tcctcacagg ggctctccgg ccgcccctct ctctgggcag ggcaggatgt 240ctccgttgga gcctcctccc acagctgatc catgaccctg tcaggtttca taggcccagr 300ctgtgaggtg aatccagaca actgtgtcag ccaccagtgt cagaatgggg gcacttgcca 360ggatgggctg gacacctaca cctgcctctg cccagaaacc tggacaggtg agttgtttaa 420gccacatcca tgacacccat ggcccagaga gttggcccct ggcctcccct actcataggg 480ctcccagcct tagccctcgt cccctcccca accccctgca ggctgggact gctccgaaga 540tgtggatgag tgtgagaccc agggtccccc tcactgcaga aacgggggca cctgccaga 599483599DNAHomo sapiens 483caatactctc atcatcactt tagaagatat ggtcactcca gataaaccct cccaagccat 60gacatcgctc agagcagggg tgatggaaca gagcaaagaa agtatggtaa taaagggaag 120gaaatatgaa aatgagaccc agagataatc cagagtgagc actgggtaac ctcagatggg 180ctagaattcg tacaatgcta gaaacggctc cctctgtcct ctgcctcagg tgagcagtgc 240cagcttcggg acttctgttc agccaaccca tgtgttaatg gaggggtgtg tctggccacr 300tacccccaga tccagtgcca ctgcccaccg ggcttcgagg gccatgcctg tgaacgtgat 360gtcaacgagt gcttccagga cccaggaccc tgccccaaag gcacctcctg ccataacacc 420ctgggctcct tccagtgcct ctgccctgtg gggcaggagg gtccacgttg tgagctgcgg 480gcaggaccct gccctcctag gggctgttcg aatgggggca cctgccagct gatgccagag 540aaagactcca cctttcacct ctgcctctgt cccccaggtg tgtcctcaca ggggctctc 599484599DNAHomo sapiens 484tcattctagg ggctctgcac cagcccctgg atccaaatgc tagctctgcc actgatcagc 60tacatgacct catataagat attttagctt tctggtgttc agttgtcagc tgacaaacag 120ggagagtaat ggtcacactt cataaggttg ctgagaggac agaaggggcc gatgctcagg 180agatgcttgc tcagctcagc acctggcacc tccactgctg ccgccattac cactggtgca 240catggactgt gaagtgagtc tccaggtgcc taaacccact taaagattag gaaatgaggw 300tcagaaaggc aaagtggctc acccaagggt atacaaccag ttgtggcaca gcatggtgcc 360acctgagtct cctgcctgca gacgtggggt gcttttcacc tcccccaaga tcacccacgt 420cccagatttt ctcaggcaag gccaatttgc aatactctca tcatcacttt agaagatatg 480gtcactccag ataaaccctc ccaagccatg acatcgctca gagcaggggt gatggaacag 540agcaaagaaa gtatggtaat aaagggaagg aaatatgaaa atgagaccca gagataatc 599485599DNAHomo sapiens 485gcctgctgcc ttcaaacagt gccagcctgt gcctgtgcgg agctacagcc cagaacaaaa 60ccaggagcgc atcctgaatg cggccaataa actattagca gaaaaagaac aaggagcaaa 120cgtgtgaacc ttgatatgct aggaagaggc catattgtat tagctttcca gtagcagtcc 180caaaggcagg aaaaactgaa ggatgtatat ttagatctct tgaaatcggg ctacttctac 240taggtattct atagccaagc aaactgtagg tgtacctagc aatattctta ttgtcatcar 300gattaacttg tgattcaaga ttttatttta ttattattat tattatttta ttttttaatt 360tatttttttg agacggagtc tcactctgtc gcccaggctg gagtgcagtg gtgcaatctc 420ggctcactgc aagctccgcc tcctgggttc atgccattct cctgcctcag tctcccaagt 480agctgggact acaggcgccc gccaccacgc ccagctaatt ttttgtattt ttagtagaga 540cggggtttca tcgtattagc caggatggtc tcgatctcct gacctcgtga tccacccac 599486599DNAHomo sapiens 486ctcgatctcc tgacctcgtg atccacccac ctcagcctcc caaagtgctg ggattacagg 60cgtgaaccac cacacctggc cccaacttaa gattttaatt gactctctgg agcaggcagg 120tgtctttgat ttgatggggc tgtttaagtc tgcgtcacta ttgtgctgcc agtcgcccac 180cctggggagt ggaacttgcc tgcagtagca ccgttctggt gttgaagaca ggaagcaggg 240tgagggaacc ctgtgggtgg aggggatttc ccagacaagg atcagaaaga caaagcccay 300gatgtcactg gaatcgattg tgctgctgag tggaagattt ctataaacta taggtttgct 360ccaactctgt gcctgccccc caaccccaac acctaattac ctgctttatc caggagtttg 420cacaacatcc acgcagtcac tgaagtcagc tcactgggct tggctatcac agtgttccct 480gcagccatcg ctggagctat cttccaggtc agcaagtaga gtggcaaatt ccaggggctg 540atcagaccag ctaagggatg agagcagaag cactgcctgt gacggcatac ccctctgag 599487599DNAHomo sapiens 487ggtgcagtgg ctaatgcctg taaagtccca gcactttggg aggctgagga gagtagatca 60ccttaggtca ggagtttgag aaactccgtc tctactaaaa atacaaaaat tagttgggaa 120tggtggcatg tgtctgtaat cccagctact cgggagactg aggcaggaga attgcttgaa 180cctgggaggc ggggattgcc gtgaaccaag atcacgccac tgcactccag cctgggcgac 240agagccagac tccgtctcaa aaaaaaaaaa aaagaaagaa aagaaattac ttagacagak 300agtgagggta tagaagacct cggtaaggtt ttcctttaaa tgaaaagcag ccccaagtca 360ttttgcttac taacaaagag cagcctgtaa aatcgagctg cagacataca agctggcagt 420tgttgtcaat tgtgttcaaa atggcgactc catcttccct tcttggccag ccaggtgtac 480aggaaggagc aaacaaagtg gcaccggaca aggggaaagt tcatttgcat aataagatta 540gggtggggcg gccagccttc tcctgagcta tgtaaaccta gtacctgatt caaccaatc 599488599DNAHomo sapiens 488tctcagccct ggacctagga gtattggctt gatgaattct gaactccttg tatagagctg 60ttgccttgtg atttactcat tctacttagg gaaaagaacc tttcaggggc acactgatgt 120ttagggagga agtgtcccac aaggagagag atttttaaat tctttatgtg ccttaatata 180ggcactctag aataaggggt aaatcaggaa ttcggaaata acctgtatca tggtaagcct 240attagtagga ctgatttctg gtatccttca tgtcatggca aatttccagt atttagcatr 300tctctcaaag aacctaagaa gagtacttca tttaccaata gaagcagtgg ctgcagaaaa 360ctttgtcatg aagaaatgca tgggaaggct cctttgtttt gcctcctatc aaaaagcaac 420ttggtgcaag gcaaagaata tctatctata atttaggaac gcttcaggtt agcaatcaac 480taactgtgtc aaggcaactc actttgccag cctctgtttg tttgtttgtt tgcttttaaa 540caggttttac cacaggacct ctaagtttct ttccggttta attttttttt ttttttttt 599489599DNAHomo sapiens 489tttagatata aaagatgatt agcttttctc acaactttca tgcaaacata actaaaaatt 60aacactattg atttttgcta aataaaagta ccaaaaacct gttatctaca tgacttgttt 120gcttaaaagc atttgccttg ggaggcaatt acttttgcac caacctaaaa acatccacca 180aagcgtttgg ggcttcccag agcctccatg ttagcaaatc ttgggctaac atgaagagga 240tgtgatgttg ttggatatgg ccaataccat atgaagctaa gtctagctga gtgttagccy 300gggggatact gccaggaaca aatgaggccc agctcccagt aatgggatat gtgtctcctg 360gatgcactct gaggattaaa ttccgtgcgc tgacacacac taaagcctct agcaaagtct 420tcatttaatt aactacaaac ttagatatat gaaacaaaac ctctgtaaaa aatcttaagg 480tcgagaacat actatataat aggcacaaga ctgaagcagt gtggggcaga tgtgatgata 540gagtctttga tgttgataga aaagcaaact ggaaaatatt cattcgtcct ccagaacct 599490599DNAHomo sapiens 490tctaactgat ggaacaaatg gaactgcaac ctagttctcc agatttctaa tctagcccgt 60ccagacactc attgttattc ttctcctcta tggtaaccgg agcaaattga ataactttta 120catccattta atggcaccat catggtttca gtgcatatca tttttaagtt ctggttttag 180gctcggttgt gaaaataatt ttgtgatgtt gcagaagaac aaagcaattt ggttttcccg 240attaagaaac tctactgaca caacatcagg attaaattca ctctggacag cagatgttay 300tatatcaaaa ccacaaaatg ttatcagggc ggttccctca gaagacactt actggcaaaa 360acttctggca tttactattg aaaaaattaa catttttctc ttataagagt ttatggtaga 420aaattcagaa aatacaaaga aaaaaaagag taaaatagaa gtctccagaa ataccatcac 480tgagaaaagc ataagcctgg ggtgggtttg gggtgggaga agaaataatg gaattatatt 540ggattatatg caatatttgt aatttgtgtt ctgcttctac aatagacatt tttcatgtc 599491599DNAHomo sapiens 491tctggacagc agatgttact atatcaaaac cacaaaatgt tatcagggcg gttccctcag 60aagacactta ctggcaaaaa cttctggcat ttactattga aaaaattaac atttttctct 120tataagagtt tatggtagaa aattcagaaa atacaaagaa aaaaaagagt aaaatagaag 180tctccagaaa taccatcact gagaaaagca taagcctggg gtgggtttgg ggtgggagaa 240gaaataatgg aattatattg gattatatgc aatatttgta atttgtgttc tgcttctacr 300atagacattt ttcatgtcat tagatatttt gtacaacatc accttaaaag gcggtattgt 360atggatatac aataatgtaa ttaactgaac atatggttat ttacagtttt ttcacaagca 420accctgctgt atttctgtgc acagatatag ttaaaatctt gggataagtt ctgaaagtgg 480aatcacttga acaaatgttt ttaatgcttg ccaaagtgct tctggcagtg aattaacctt 540gtaacaataa atagtattac tgaaaacaat cttagtccat ttgttattgt tttacttta 599492599DNAHomo sapiens 492aaattaacat ttttctctta taagagttta tggtagaaaa ttcagaaaat acaaagaaaa 60aaaagagtaa aatagaagtc tccagaaata ccatcactga gaaaagcata agcctggggt 120gggtttgggg tgggagaaga aataatggaa ttatattgga ttatatgcaa tatttgtaat 180ttgtgttctg cttctacaat agacattttt catgtcatta gatattttgt acaacatcac 240cttaaaaggc ggtattgtat ggatatacaa taatgtaatt aactgaacat atggttatty 300acagtttttt cacaagcaac cctgctgtat ttctgtgcac agatatagtt aaaatcttgg 360gataagttct gaaagtggaa tcacttgaac aaatgttttt aatgcttgcc aaagtgcttc 420tggcagtgaa ttaaccttgt aacaataaat agtattactg aaaacaatct tagtccattt 480gttattgttt tactttaaat ggtatcttgc caggttttta aaactctgta tttcttttgt 540tactaatgat actcaaattt taaaatatat ttatctttta ttttactttc ttttgtgaa 599493599DNAHomo sapiens 493acttcatcat ttttatactg ggcatttttc attattcatt tctgtggatt gttatgtagt 60actcctttgt tatacatgta gcaatgtctt tatcagtctt ttttcttttg atttttattt 120tttactaatt tatttttgtt tgtctttgct tttttttttt tggagacaga gtcttgctgt 180gtcacccagg ctggagtgca gtggcacaat ctcatctcac tgcaacctcc gcttccaggg 240ttcaagcaat tctcgtgcct cagcctcctg ggtagctgag attacaggcg catgcaaccr 300cacccgacta attttttgtg ttttagtaga tacgatgttt caccgtgttg ctcaggttgc 360tctcgaactc ctgagctcag gcaatccacc tgcctcagtc tcctaaagca tgattacagg 420tgtgagctac tacacatggg cagattctta atttttcatg ttttaacata aaacagctct 480caaagtttta agctttatgt aaactaatct gctacctttg gcaccaaact tagaaattct 540cactctacct gaatattgta aaaatattaa caattattct ctggtactca aaggtttta 599494599DNAHomo sapiens 494gtttcaccac gttggccagg ctggtctcga gctcctaacc tcaggtgatc cacccacttt 60ggccttccaa agtgctggga ttacaggcgt gagccaccgc actgggtcaa gggtgtctct 120tgatagcggt gggaaaagtc atgaaaaatt cctcaagagt agcagctcct aaaattatct 180tagaacccag attgagacaa aaggctgcaa ggacttgcca tctcacagat tgccaggctg 240tcttgcattg tgagcccatg gatgggatct acctctggct gattggggta ggccataggw 300caggacattt aacatcccca aaggaccctg cagaacaaga tttgtcagcc aggactgcac 360cagcccagat taagcttact ctctttctct tccttcatct ctttgtccct acaccacaga 420aaagtggatt gaaagaatga aactatcctc aaacattagc tcataaggga aagaacaaat 480atgtctcaga ggtaagttaa aatagagtta gggagaacaa gccacactat attatagaaa 540gcagaatttt gaactaagct ttaattcaat ttccagttaa attcagtata aacaagagg 599495599DNAHomo sapiens 495tcatcagagt ttcccaaaat gaaactctgt atccattaaa cagtaactcc ccagatctcc 60ctctgcagcc cttattaacc actattcttt ttgtctctat ggatttgcgt gttctagatc 120cctcatataa atggaatcat tcactatttg cccttttgca tctggcttat ttcacttagc 180acaatgtttt caaagttcgt ccatgttgta gcatgtatta attttatttc tttttaagat 240ggaataattt ttcactgtat gtatacacat tttgtttatc catatgttta tccatttgty 300catgaacatt tggtttattt ctaccttttg attactctga atattggtgt acaaatatct 360gttctagttc ctgctttcaa ttcttttggg tatagatcta gaagtggaat tgctgggtca 420tatggtaatt ctatatttaa tttttttgag aaattgtcac accatttttc caaagcagct 480gcaccctttt acatttccat aagcaatgca caagggtttc aatttctcca cttcttctcc 540aacactttac aaaatatata caatgagcat tctaataggt gtgatgtaat atctcattg 599496599DNAHomo sapiens 496agtttgaagt tggccagagc acacttgaat gacagaatcc aaggaaccta ggaggatatg 60acagcatctg ctatgtttga atacctactt tgtcccaggt attattctaa gtgttgggat 120ataggccata gacaaaaatc caagctcatg aagtctatat attctggctg ggggagacaa 180atgataaaca aacatatagc aaaagatggt aagtactata aaaaagtaaa gctggttatg 240ggaatagaga gtgatggggg taagaaggaa accagtttag aaagcgtggc tggggaaagw 300ctctttgtaa agtgatacat gagcagagaa ctgagtaagt gagggagata acctagtaag 360tatctgggga cagggagatc cagagagaag agtaagttcg aaggccctca gataagagtg 420tcccagcatg tttagaaaag agtaaggagg ctaatgttac tggctagatt atagggagaa 480agaaaaaaat ggcagctggt gaagtcagaa tattgggtag cagtgagatc ctgtagggct 540ttgtagacca caataagaac gtgttgtttt attatattat ggtgttatat tatattgca 599497599DNAHomo sapiens 497agagcacact tgaatgacag aatccaagga acctaggagg atatgacagc atctgctatg 60tttgaatacc tactttgtcc caggtattat tctaagtgtt gggatatagg ccatagacaa 120aaatccaagc tcatgaagtc tatatattct ggctggggga gacaaatgat aaacaaacat 180atagcaaaag atggtaagta ctataaaaaa gtaaagctgg ttatgggaat agagagtgat 240gggggtaaga aggaaaccag tttagaaagc gtggctgggg aaagactctt tgtaaagtgr 300tacatgagca gagaactgag taagtgaggg agataaccta gtaagtatct ggggacaggg 360agatccagag agaagagtaa gttcgaaggc cctcagataa gagtgtccca gcatgtttag 420aaaagagtaa ggaggctaat gttactggct agattatagg gagaaagaaa aaaatggcag 480ctggtgaagt cagaatattg ggtagcagtg agatcctgta gggctttgta gaccacaata 540agaacgtgtt gttttattat attatggtgt tatattatat tgcaagatag atagaaaga 599498599DNAHomo sapiens 498atattatatt gcaagataga tagaaagaaa gtggaggctt ttgagcagag aagcaatttg 60atctgtgatg ttgccagtca aaattggtga ttgccatatt gtttctgttc ttcactctaa 120aacaccaaaa atagtaaagc aaacacatga tcacccatcc attcatccat acattgagaa 180agcctttcag agttgagtaa ttccggctcc ctttctgcta ctgccatctg ggacaagctg 240ctgtggggag gtagtaactg ggaggtagct catatgaaga agacaggcag aatgagaaam 300aaagacgaac aatgttggcc aacccaatga tcaccactct tcattttttt tctttttctt 360tccttttcat ttcttttctt tgaatctcta ccttaaagaa ctacacatag tccttcacat 420cagaaggtga cactatagtt cttgacagac agaagatatt caagaaatat taatgaactc 480ctaaaatctg tgttaattta tggcatgtaa ctggtgcagg gttaaaaaaa aaaagaccaa 540taatgacata aaatgcacat taacataagc agcagaatat acacaggtta aaccaaaca 599499599DNAHomo sapiens 499atagatagaa agaaagtgga ggcttttgag cagagaagca atttgatctg tgatgttgcc 60agtcaaaatt ggtgattgcc atattgtttc tgttcttcac tctaaaacac caaaaatagt 120aaagcaaaca catgatcacc catccattca tccatacatt gagaaagcct ttcagagttg 180agtaattccg gctccctttc tgctactgcc atctgggaca agctgctgtg gggaggtagt 240aactgggagg tagctcatat gaagaagaca ggcagaatga gaaacaaaga cgaacaatgy 300tggccaaccc aatgatcacc actcttcatt ttttttcttt ttctttcctt ttcatttctt 360ttctttgaat ctctacctta aagaactaca catagtcctt cacatcagaa ggtgacacta 420tagttcttga cagacagaag atattcaaga aatattaatg aactcctaaa atctgtgtta 480atttatggca tgtaactggt gcagggttaa aaaaaaaaag accaataatg acataaaatg 540cacattaaca taagcagcag aatatacaca ggttaaacca aacaatcaca caggggatt 599500599DNAHomo sapiens 500cctcttttgc taggaggttg gactatcgtg ctcgttgaaa atgggggcga ggaatcagga 60gacagagttg aggtttcccc ctattgcatt gtaaggtatc tgtagaatgt tctatagaca 120ccttttcaat tcaattcctt gttccaggaa gaacaagaag catttccacc aggagagcta 180catcctgaaa acgttaaatt ttcatggtgc agagtggaat aaaagaaaaa accgacttca 240attctctatt ccatctgtga gaagagagca gagaagttta aagtgtgtga ccttgagacr 300gatttttctt ttctgttctc tgtcatccga ctaaaagcag gaaagcagag gagtcatctc 360tacacctctg gaaaagagca cccattgtga caatgacaaa gggcagtttt gtccatcgca 420aacacgggcc tcggggcagc agttctggtg aaggggaaag gagaagcccc agaaagcttc 480atggtcacgc cacgtatggg atgctcggca gctgccctgg ctgggatcta acaacaggaa 540gccagcggac ctcacggggc cattcccagg cttagattga agggagtaag ttggggagt 599501599DNAHomo sapiens 501tccagaagat aattaaaaaa ttcacggaga aattatgcaa aaatacgtaa taaatgatgg 60gggaaaatca caatcactgg accttgcatt actatagagg aaaacataag ctttactaat 120gaaaataata tgatatgggc attgaagtgg acataaaaag agaaaataat tggtaaccaa 180gaattcaacc ttacttgtat agaaatatgg taatttaaat ctaagggaga aaggtaataa 240atgttattgg gaaatttaga aaatgatttg gaaaagaaca aattgaataa gacatggtty 300ctccgctaaa gaagtaaagg gtttagtcaa cgcataccac atttcctcat tttcttatct 360ctcgtgacac gcacactatt ttcgggagga aaccaaggac ttttttccca atctcttttc 420tttattccca agaaaattag tagttccaag accatggaga cagtaagctt aatgatgcat 480atttgaggtg gatttttctg caccttatta aacaaatgct gcttattttt gctttttata 540aagactctga tttattgttt ctagtatttg ataaaaagaa aatgttttat tgctatttg 599502599DNAHomo sapiens 502tgagttcttg attgtttacc agtaaatgtt atttttcata tctgttgaga taattatata 60tattttcttt ttatagattt ggtcttaata gcttttctac gaggttgtaa acgttattcc 120caaagaggtt tataactggc actttttctt ctttcacaga tctaagttcg ggaaaacaat 180tggtacagga tgtgcagctt gaagaagctg aggggatgag tatactaaat atgccacact 240gtctgcacca tgccaggtag tctagtatgt attgggttcc attgagactg atgctgcaty 300gaattctgat gatacagttc gctgcgcttg tccactctgg tctgtaggag aattgccaca 360gtcttatgaa tataaggctg ggtttggagg gggtcagttg aaattttagg agttttcata 420tgactcttac tctttcagat ttgctatctg caattgcaca tctgccagtg acctctgtct 480gttactgaag aaggctgctg gcttctttgc tgtatatcct gatcacgctg acttccttct 540gcaacttcta gataagtaaa tttttttgat ttatcaggaa gtgtctttgg tctctcagt 599503599DNAHomo sapiens 503tgcttatggc ttttggatgt acaatttaag ccaaaacagg atgggttaca ttggtgaagt 60ttactttttg cttctgaaat aacatctaga atgttagttt gtagaataaa cattttctaa 120gaattttttt acatttttta cctgtaaatg caactctttt tacaattctt catttccttt 180ggaaggagtc caaaactact tacctggaag accttccacc accccctgag tatgaattgg 240ccccgtccaa gttagaagag gaagtggatg atgtctttct cattcgagct caaggactgy 300cctggtcatg cactatggaa gatgtgctta actttttttc aggtatattt tatgtatgtt 360ttatttattt attttttttc cttatattgt ttctcacaag caggtatgta tgttttaagt 420atgtaatttt gtctgagtaa aaggtagtgc tacaaatcca tgtcagacta cgctgtcacc 480ttcctttttg atggttggga actgtctcat tctggttggt tgcatatacc aaatgatacc 540atgtgtgctg tttgcggtat gtaacgaatt gaaagacttt gggccagggg cagtggctc 599504599DNAHomo sapiens 504gtactctaca catgtgtcaa caatttaatg tacactatga tacaagaaga taaagataaa 60agaagaaaat atttatacat ttctttacaa ctaaaaagcc tttctaaacc aagtctcaaa 120atctggaagc caagaattaa aaaaaaaaaa aaaaaagact gatcaagtag actgcataaa 180aatggaaaaa tgcaacatgg caaaagacac cacaaacaac

tgtacagaca aatgacaaat 240tgagataaag catttgaaat tcgtagcaga agcaatactc taaaagcccc tccataccay 300ccctaatact ttaaaagccg ctagaaattg agaagaaaaa aaaaaaacct gaaagaaaaa 360ctattgttca cagaaaagaa aatacagatg gccctaacat atgaaaaaaa tgtccaacct 420tgtttataac aagagaaaca cacattaaaa ctacactaag ataacattgt tcgcctgaca 480gatttgcaaa gtttccacca gcaagttggg ggagaagtcc tattcagggt aggtgtgcaa 540agcagagcaa ccaccataaa gggcaatttg gccagatata agaaactgca agctgcacc 599505599DNAHomo sapiens 505gaagaaaaaa aaaaaacctg aaagaaaaac tattgttcac agaaaagaaa atacagatgg 60ccctaacata tgaaaaaaat gtccaacctt gtttataaca agagaaacac acattaaaac 120tacactaaga taacattgtt cgcctgacag atttgcaaag tttccaccag caagttgggg 180gagaagtcct attcagggta ggtgtgcaaa gcagagcaac caccataaag ggcaatttgg 240ccagatataa gaaactgcaa gctgcaccct acttctgcag tgttttctca caaatacacy 300ggcctgtata taaaattctg tatttacaag gctgtccact acattattat ttattataga 360aaaaaattaa atgggacagg cagaattcag aagagaactg ctaaactcag ttatagtcaa 420tgcagacaat ggaaaagcag gctattacaa aagcaagtga ggaagctttc cttatatttg 480tgtggaaaga tcttcagaat acatggttaa gtggaaaata ggcaaggtga ggatgaagtg 540tatagtatgc tacccgtact ggtattaata tcaatcagat atggaaataa ccacttcac 599506599DNAHomo sapiens 506gaagaaatga gtaggcactg ccaggcaagt ctaagaaaac agaccacaac cacttgcttt 60ttgaaccttg tctttcccat aaagaaattt acaaaaagaa aaagaggatc acaaaatata 120aaatactccc agaagtctag tccaaaaatg tctatcaaaa ttaaactttt ttttcccttc 180agacttgtaa gggcaaaagt aaagcagata atccatgtga gttctagatc ataataaaca 240aaaattcaaa tgggcaattt atttttctaa gtgacaagta agtatagatc tactaaatay 300aggatttgtg gtcattgcta tatgtaggta gggaccagat gcttggtcac aagggatacc 360gaatgagagt gaaaagccac ttctactatt cagacactca aaagcatgtg gcatttgctg 420tttataaaat gtttttccct tgtgtgaaat atttctgaac cgtggtctcc agggcacgca 480cgttgcgctg ttttttcctg gagtcgtgtt tcgtttgcac aaactaaccc acattttctt 540ctgtgattct tcatatgact aatgaagcac agctctgagg ttatgattta gaggaatat 599507599DNAHomo sapiens 507tttccaacaa acttaaacag gacttttagg acctggtgat gactctgtta tattttaaag 60tataattcat ccccaggaaa tctatgaatc acatagagtt ggcccccaga gataagttgt 120ctacactttg aaaaattatt ttttatctct gtatgctctt aaattgggag aattctggtt 180aattgatcag aagttaggga gctttcaata catgctgttt tcacctcacc acaccactgc 240atacaatgaa ttccacaagc tcggacatat tagggagcat ttgctataaa gtggccccar 300gaatctacac atttctaatg gtaaacagtt gagataatcc aatatctttg cccaacacaa 360tgggttggaa caacctgtca cataagacaa acttccactt ctaatgaaga taaaactgcg 420cttattcttt cattcgttct ttaggcaaag ttccttcccg tctcatctgt gccttgccct 480ccaccctctg ctctcaccac aaagccctac ttgtgccttc tgataatcct catccactct 540cccttctcta accacttaac ctcttcacct tcaagccatt ttctccctcc ctcaattct 599508599DNAHomo sapiens 508gagtcctgca agtgctaagt gggccagctg aactgcaaac ccaggtgatc tagctccata 60gcctctatat tgtacatcat gtagactcag gccactctca cagtataggg gctacattca 120agatggtcct gcagatgctt tgacttcgta aatgagccta gtattctcag ggagtgctgc 180ccgcctgtcc ctaccttttg ggagaaaggt catgaagtaa attgttatga ctccttggcc 240cacatcgctg gactcgttgc attggaaggg acctggcctg cataagtgtc gaatctctaw 300cagtggtacc attaacctct taacaaacat ctattctgtg tggagtactg tttcaggttc 360taagcatttc aactaatcag agatggccat gatacttacc ctcgagagtt agggaaacag 420caaatacaga aaaacaggct agggctaggc acaaaattgt cttgtgcacc aaatttaagg 480ttgtgggggg tgtgtcataa aaaacaaagt catccaggga aataatattc taatgaataa 540ttttagaaat ctgaattaac acacaaaaaa tcatgatgaa caaaatatta aaattttaa 599509599DNAHomo sapiens 509taaaatttta aatgcaggta agatcagtat cagtgccttc ccaaaccata ttggagcctg 60aggcaaaaag aataatcaga ggtacccact cctctcccta gtcccgccct gtaggaagga 120atcaataatt caagatgcat atgtccattt ctttggccct cagggccaca ctcaatccca 180gaatagaatc aagactctct tttaataact tcagtattaa acttcattcg gatgctttat 240atagcactaa aatggacaat taccatccat tcccagcatg atactctccc acagccatcr 300tgtgggcata aaataatatt cagaattgaa ataatctaat taaccttatc tttaaaaatg 360ggataaacca ctattttctt atcgattttt aaaaatcttt gagttaaata agaagtagga 420ttacaggtga ctgaaaatgt caagattcag taatattctg taaatgagga aactgaaaat 480agaatataag cactagctta tatctttatt tttatcctat tatgataagt gataacaata 540taactatatg caataattta aattttgaaa ttcccaaact aaatgtaaaa aaaaaaact 599510599DNAHomo sapiens 510gtagtcccag ctactcggga ggctgaggca ggagaattgc ttgaacccag gaagcagaga 60tcgtgccact gcactccagc ctggcaacag agcgagactc catctcaaaa aaaaaaaaat 120ttttttagag acaagatctc cccatgttgc aggtctccac ctcactcaag caatcttcct 180gtctcaacct cccaaagtgc caggattaca gcagtgagcc actgcgccta gccctgtttt 240ccttccttta tggctgtttt agagtttatt gagatgagcg ttagggctag tattgatgar 300taatacacat ttatattaat aaaagattgg atagaagata ctacctcctt tctctcaacc 360cctctcagag attttacctt aaaaaagagg gaccaattca atctagttct aaaaagggaa 420aactgacttt attcatcagt gctgaattca ttacaatagg gacctctcta tccaaaaatc 480acaagccttc aatttctgcc ctcatattta gtctcaagga gtgacccact gagtggggaa 540aataatttca aaggtgtcac aaaggtacct tttctttccc tttttttttt ttttttttt 599511599DNAHomo sapiens 511gttaaactgc ttagctatgc atgaaaagtc aagagttgac tatatgcagt tcaatttaac 60tttctgtaaa gaatccatta gggactaaag ccaggcttca gcaaaaatta aaaagacatt 120tcctgaaacc aataaacatc actcactaca gttgctactc agtacaattc cctttaccaa 180tagcaatttt aacgttcaca gagaacttcc catgtgccaa atgctaggct cagtgctagg 240gctgggtgtg catgctttct cttcattctt ataagcccct gtgatttacc tgctgtcaty 300gtcctccttt tagagttgag aagtgaagta actagctcag gttgacactt tcaaccaaag 360ggagagcaga attgtgaatg aaattatttc tctctgattc gctgcacaca tttcattgaa 420aaatacaaaa agttcaggag gaaatgttca gctctgactg gccagtggca ggatttggtc 480atttggccat gttaagtctc gacaatttct ctctggaaac ccttttagaa ctatattcca 540tgagggagct tctgctttgt gagaaacctg acaaaagcag cctctttgct tactgacaa 599512599DNAHomo sapiens 512agagagacaa aaggtgattt gacaaagacc ttcaaatgaa gttagtctca tcactcctaa 60tccacagttc tacttttaaa tgaactttcc tgctttatta cctctgggct ggtagagatt 120tgaagattca ttttcccctt aaggatagtt atgtcctagt tctaagacct actatgacta 180aatgctccaa gtatgatttt agtcattagt ttcaactttt gaccctaaac tctgtctgga 240cctgtgtaaa gccagagacc ctacttaaag ctccagtgaa gaggaggcaa gagaacacaw 300ccctcctgcg gtgcttataa ctcagctcgt aacttgatgc caggaacatt aaaccccact 360acaaagtcag actcctccat atacaagact gtagatcatc ggagtctcat ttcagcatgc 420tgaagaaggg gctgaatttt aatgtagacc taccatctcg cagtatgtgc agctatggca 480atgcattgat cctctggtag aaattagaga tctctttcct ttaagcccat tcattaccag 540gcctcggcgt gtagagagaa gggagtggta gagtggttta ggttagacag tggtggcca 599513599DNAHomo sapiens 513attgatcctc tggtagaaat tagagatctc tttcctttaa gcccattcat taccaggcct 60cggcgtgtag agagaaggga gtggtagagt ggtttaggtt agacagtggt ggccaaagca 120atgccagtag ccatggccat gatgcaggta gacagtgtgt gatagcccag tcacttcctt 180ctggcatgag gtcaccccaa ctttgaccca gctctatgca caaacaagta aaagtctaag 240gaagtgttct gttgtgttta ttctagctgc gcatgtcaaa ttgcttttag caaggctgaw 300tctgtttaat gctgagaatg ggaggtggct gacaaccctt tttaacagta cagacaattc 360tggctgagta cccagtttac acaattgcat ctgtaaacac atgtggtgga ggtggtggta 420atagacttgt attatggttc gcttagttcc tgagtacgtg attaatacta attgtaacta 480caaacaagta ctgaagctac tcctctgcag acaaaaaaaa aatatatata tatatatata 540tatatatttt tgtctttaaa cccatttatt accaggcttc agtgagtaca gagtagtag 599514599DNAHomo sapiens 514agctttcagt tcttcaagtg caaaaaataa aagcttatga ctagaattct gattctcttt 60agtttaatgt gtatttctgg ggagaggaaa agattaacgt tcttatacca aaatcttaca 120caaggtttca tctttttttg gaaatcaaca actacatttt aaaagcaaat tctttgaact 180agaagtttct gacttttagc agaaaactac acgatttaat ttttaataat tataaaatac 240aatacttaga tttgtctcca atctttgtat gtagcaaata acatacttga ctatggttcy 300atcaaattca catttatgga tgaaatagtt gtttagaact agatttaaat tagttgaact 360tctttcagct tcattctgta aggcagaatt aggttgattc tacaaaatgg cacataataa 420gacacgagtg actcctcact ttttgggtcc aacagtaact tcatgaatct aatgactgct 480atggaaactc tcgcctttaa aaaacgaaaa cttgaatata ttcattgtat tttacataaa 540attttgtctc ctaaagtcta ctcacagacc taaaatatac attgaatttt taatttgta 599515599DNAHomo sapiens 515agagaggcag agcaaaactg aaaaagtcct ctttccaagg ctaccaaatg caatacactt 60gctaagattt atcacctacc taatgaggtt aattgagatt tttttactcc agagtctcat 120gtgggcctat tcttgaccaa acccccgctc aaaaactaat gtacaccaag aggtaatggt 180tacaaatgga tcaatgtggt catttaattc aaagcaatgg ttggaacagg agtctgacaa 240caccctaggg ttattaagtg tcagaacaac agggaaagta actttgctca gggcaatctr 300ctgaaaacac ttaacattgt gctgtgcacg gtggctcaca cctataatcc cagcactttg 360ggaggctgag gagacaggat cacttgagcc caggagtttg agcccagcct gggcaaacat 420agggagaccc tgttgctaca aaaaataaaa ctaattagcc aggcatggtg gcacacatct 480gcggtcccag ctactcagga ggctgaggtg ggagggtcac ttgggcccag gaggtcaagg 540ctgcagtgaa ctgtgattgc gccaccgcac tccagcctgg gtgacagagc aagaccctg 599516599DNAHomo sapiens 516gtcataaaat aggaagtgat gagttttgaa tatttattgt cttttaaaat aaaatatatt 60taactgtaag tttatataat ttacttttta ataatggctg tgtctaacaa ttaactcaca 120aaatttagct cccgtgtatt cctgacccag cttgacttcg ccagcaggct ctgatcccac 180actctctacc acctgctgaa caactctacc cggatgtctt ccataagaaa ccacaaattt 240aacataccga aatctaaaca tgctttcctc tttgaatctc ccagtgcata cttctcttcr 300cctcttgact tccctatttc tattaatggt gcctctaata tccttagcaa cccaatcagt 360tgctaagtct tgaaggctct gcctatgttc ttctgatctg cctcctcctt ttcattccac 420ttacggttac tgtcctaccc cagacaatta cctagcctct tccccttgtc tcttctcact 480ccaatctatc tgacaatact gatagattaa tcttccacac acacagctct gataatatag 540ctttgctatt caacgcacat acatgaatcc ggccttcaaa gctctccttg cttcaggca 599517599DNAHomo sapiens 517gagttccttt gagtaactta accagctacg tgaactgcca gagacaaact gtcttcagtt 60tctttctatg catttagagt tttatagttt accaagtcct ttgacattca ttttacttga 120tcctaacact ggccctgtat gattcatttt ggaaatgggg aaattgaggc tggggaaagc 180taaatgtctt cacccagggc tcactgtcag gtggatcctg gaagttctca accaaataaa 240ctctaagatg tcttcaatct ctaaaagcta tgtagctggt ttatctaata aaacacttay 300gactgatgaa atataattta ctcaccatac atttaaagca gaatgttcaa tacccactcc 360ctcattcttc ccgatcaata tattttttga catattatta ccgtccaggc agtagctttg 420cgatttctgc ccatctgttc cccagtctct tgtgtgcctg gtaaataatt ctgtcttcct 480cttctgtcca ggaggttttc ttaacttctg gattcaagtg gttatgccac ctctccctac 540attgttttcc aattctcccc tttaagtgct tggcaataac agaccaacgt ttcggaccg 599518599DNAHomo sapiens 518agtaaaaagg aaagggaaca tggagaggag agcagagtct tggccagcaa tctattaatc 60ttgtcttcta gaatgagttt gctctggaat tttctgattc tttgatgttg caaggtgaaa 120taactcatca gtcagcatcc actctagcct gagatttcac atcactccct taagtctgaa 180ataacattca caaagatttc tgcaggagcc aaatttggtt ggtggtgttg tcacagtgag 240gctctttggg ctgtgcggca cctcatgacc atattggcta cacccattgt atttgcagcy 300tccaatcaga cctttgtctt tatttccctt actttgtaat ttcagagaca ctataatgat 360gaagaccctg agaaggaaaa gcgaataaag gaattagaat tgctcctaat gtcaaccgag 420aatgagctaa aaggacagca ggtgctacca gtaagactgt catcatgtgc ttgaatgagg 480ggatagcagc tttgcctcag tttacctaag cgctcttctc ttctaaatat tacacttagc 540aaggctccat atatccattc agaatgtctc aacacaagaa gttgcttgta gtaaaatgt 599519599DNAHomo sapiens 519ctaccgagag agacaaaagt atttataaat acttacaaaa taggactttt gaaggaagag 60ttttttttca cattttcaca cttttccttc aaaagtcata tttttaaaaa tagtcagatt 120gatgacttat aaagcagagc ttggattatg ggaacggaat ggtgtttgag ttacttttaa 180cttttttttt tctttgctta cttcatggtg cttctctaga attttgtctt gcttttgaac 240agcacattaa tgatttggct tactcagagc tgaaagcaat cttttagtgt atttgaagtr 300ataatcagct ccttggtcat acctggctct ttccacaaaa tggtgattat tgattactgg 360tcccattgct tcactgagat gaatcatctt tcgtgaaaca aatttgtatt cagcacctcc 420tcagcgaaca cttggttcct ttcccagttg attaaaaatc atttattgca cactcattgg 480ttaggagatg accattgccg taatatgcca tctagaaaag gtcttcattt tgctttccat 540tgcatgcaga tgtagagtgt cgggaggtcc ctgcagcaca tcagagggcc agccttgag 599520599DNAHomo sapiens 520atcatctttc gtgaaacaaa tttgtattca gcacctcctc agcgaacact tggttccttt 60cccagttgat taaaaatcat ttattgcaca ctcattggtt aggagatgac cattgccgta 120atatgccatc tagaaaaggt cttcattttg ctttccattg catgcagatg tagagtgtcg 180ggaggtccct gcagcacatc agagggccag ccttgaggca gcccactaga ccctgctcta 240ctgcagtata atagagcaac tgctcatctt gaagctgttg ctcaagaagc caaaccaacr 300ggcctagtgt ttgctttgcg ttgagcatct ctctctcagt gctgtttcag gtgatgatgg 360cacacactat ctcaaagttc tgtgcctccc acattgtttc aggattcttc atcatggtgt 420gatctcagca gttttgaatt ctttgaagaa gcagattttt cacctagcca acatcacaca 480ggcaaagccc tacagcttca gcaaagagag ggcaatggga ctaaacctgc aggagaacct 540agcccaaggg tgaacaaacg tatgttgagt gagagttcac ttgacccacc caaggtctt 599521599DNAHomo sapiens 521gtatctgttg aatttgtttt aagaacagat ttaggtatga tataggtata tacatttggg 60aaacactgaa tcaaacaaag ttacaagtag gtttcttagc tgggcatagt ggcatgggcc 120tgtagtccta gctactgggg aagctaaggc aagaggattg cttaagcaca ggagttcaag 180ttcagcctgg tgaacatagc gagatcccat ttctttaaaa actttctttt ttttaactgc 240aggccttctc agagttatta atatgccgtt gtgccttgtg aatttccagg aggagattay 300gatatgttgt gtttcccaaa tttattttac cttggaattg tttaaggaac acctagtttt 360ttcccagaac tttagtgttc tgagagacac agtttattat tcaagaattt tccatataat 420gtaaaccttc tgtaatacta attttggttc atagattatt aaagagaaaa aacaaagtat 480gaaaggaaac tattaattat taactattat tttccccaaa atcactaaag ccttttaaat 540gttaataaag aacacatctc attctcttta atgacaagtg tcatttattg agagtattt 599522599DNAHomo sapiens 522aaaataaaat ccttgacgga tacaacacta ctaggtgtat cattaaaata tattcttaat 60agaataaaca cctagaatca gaacattggt tgaaaacgta ggagctttac aggggcagta 120aatttggagc tagtcacatt tcaaatttgc catcagtgtt tctttgttga atccagaaga 180tagagcaaat tgagctgata gtgtaagtta gcaacatagt tttataaaag tatttgaggg 240actggccaga aatatactcc tgactgtaca tgtttcatag gaagttctag aaacaacaar 300gcactttcta tatgctttta ggtggaatct ccaactgata aatcaggaaa cttcttctgc 360tcacaccact gggaagggga cagtctgaat acccaactgt tcacgcagac ctcgcctgtg 420gcagatgcac cggtaagtac gtgtgcacca gcccccaagt tgttatgtga cactggtgcc 480tcatgaaatc ctgtgtgtgg catagggctg ctgcggtttc agcactccct ctttaacaca 540tcttatttct aaatgttctc ctgcacatga tttttaaaaa atgattatta atgtagagt 599523599DNAHomo sapiens 523agtccttggc tccatgtgca tctaatcctt gccataagcc ctgcatcgta cttcatattc 60accatattga actattcacc ctcaagtagt cactattaaa tgtcacactg ttgtagcgac 120tacaaatgca agctcagtaa ctgaaaagat aacattaaat tttgtttttt aattggtttc 180ctgtgtcaat ttcatgtttc gggaatttgt atggacagat agacaccaga gagatatgcg 240tatttcacct gcatgcttga ggctagagaa acatgattta ttcagaacta tttcaaatay 300tgtaactaac ctggtaattt tgtttaggaa aacattaaat tcggaataga aggcaattca 360gaatacctgt ctgttatctt tgtcttgtca tttttgagat actcagttcc tggaaaatat 420tatgataatc catcttgcta tgtagtattt caagttatat gttgagcctc tgagcttgca 480gagtgaacat ttctattcat agacagtgct gttgacatca gtggggagat ggcacaagct 540ttgtgcccta ggaaagttta aaagctagaa cattacactg caaaccctat gtcaggaaa 599524599DNAHomo sapiens 524tctctcccct aatcttagct gttttcaccc tttccccaca gcattgcctt gacagttcct 60cagtgtccca tcccctcttc ccatggacaa caccacaaac ctgcgcacac ggcctgttat 120tattcctcct gtttcacctg tgtccattct gtctcataaa ggacactgta ggctctgaac 180agctaaggcc tttcttattc ttttgtccca tggaaaataa tccctccaga tagcaatacc 240aggaatagtg ccttttctaa cccactggtt tccttttgag cttacagcca ccaaatcttr 300tatctgtttg tttctgttcc cctctctgca ttgactgcta gagagatcag agtcaagcag 360gaggttacat ctagctgggg cactgtgctt tatgctggtg tttcgtgtgc aaatctcata 420ccatcttcat gttacagttg ttccttagtg tccatggggg atttgtttca gaacccgcaa 480ggacaccaaa gtccagggat gctcaagtcc ctgatataaa atagcattgt gtttgcatat 540aatctacaca catcttacca tataattttt tttattattt gtatacattc gtggggtac 599525599DNAHomo sapiens 525ctgggctttt gctgccaata gagatcaaaa tctatgacca cttggtgcca gctccttggc 60atgctcagaa tacaaaagaa ctgggccaca gggaagcaga gaaatgacag gtcctggctg 120gcactgaggg taatggaggc atcaaaggag ctgtcactca gagaccccat ctcagtggct 180gtgatggcag caagggccta ggatatgcca tcatgggaag gggctgcagg cactcagtgg 240agccagtggt aacagtagag atgtcaggta cagagcctga attctcaggg actctatggr 300aaaaaaagga gttggtgcag gcttctggga atggggcccc tggaatgaag tgaggtgggc 360actgaggtgt aagtgaggct cctctcctgg gaaccagact tggtgggctg cagaggagcc 420cccagcaacc aagcaacccc cacaaccagg ccaccagcct atgggtataa aggaagtcac 480atttcccagc aactctagaa gaagcacctg gggagccacc tgacctccca tcagggaaag 540gggctgcctc ttgacagcct cgcagaagtg cttgacactc ttgtcctctc cagaaaacc 599526599DNAHomo sapiens 526gaattgctcc ctcctctctc tccaccacct catccctcca cccagaggta agagacatct 60tcatagctct gtaattgtga ctgtggctaa gcagccgtgt gatcgcaggg aaaggggagc 120caggcacgcg ggaggggctc ggacaggctc tgacccatgc tgccaacaca cctccatctg 180tcagcgacag ccctccctgc gtggggagtt gatggagcgg tgactgccag tttgctaacg 240tccttgtctg cggatgctgc aaagacatgg ttttccatgg aggaattctg aggcttacay 300gcaagtcttc tctgaattac agtaattaaa gttgagaaga gcaacacgcc agaactcctc 360ctttacctgt catttctggg ctgatgacgg ggctccaact tcaaggtcac tctgtcctcc 420tccctctttc cttcctgccc ctggctcctc tccacaccag gcctgaaaca gccaaggacc 480caaccttccc ccatcacaaa aggcagccaa ccagatccgg gggaaaagca ggcaccttcg 540aactccagtg cttgggattt caagttgagt cttactggct tggttcccag caggaaaac 599527599DNAHomo sapiens 527ctgacaccgg gtttattcca ctaccccagg gccatttgtt gaagccagcc gttgtgttaa 60gcgctttaca taaattattt ctaattttta cagcaacttt tcagggtatc attatcccca 120tttcaggatt gaggtaatgg agtgatttgc ccaaggtcgc atagatagaa agtggcaggc 180gaggaattca agtctgttat cccattcttt ctcataaata tccatcaggg gcagagagag 240gcgagtctga gtgggtttgg ggatgtgtga gggtgtccca aaggaagaag tcctgaaags 300tacctgctgg aacatcccag ctacaggctt ccacggatta cattcacctc accaacggta 360aggcccacat atggccagtt gttaacaaac atcgtaccaa gaaggaaaaa agccctgagt 420acaagtgcct ggaggttgat cttcaacagg gaagatgtag aaaggcagat gaaagctaag 480gaccctgaaa ctgacagaag gtcagggaga acctactaaa acccacaggt ctcccttggg 540tttttgtggc taagctggtg ggagtgagaa gaaacccaaa ctcccaattt agtttccag 599528599DNAHomo sapiens 528acctcacaga aaatgatggg attcttgtgc tcccagagcc caaattctat actcctcact 60cctacccaag gcctggaaag gtaagaggct ttagcagaga caaatcagag aaggagtggg 120gtcggggggg caaggagtaa gaaagtggct ttgtggggaa

gacccagtcc tacacagctc 180aggaatgcgc tagagggctg accagtccta taatgccttg cctttgtgga cacaggactc 240aaacatttgc aagaagatgt tagacaccat aacgttagct ctcgccacaa cacgaaatar 300ctagtatgtc attgtcagtt gagttatacc aactttctca tcatttttct ttgcaaaatg 360aggacaataa tagtatgcac cgcacaggat gtttgtgaga attaaatgag atgcaaagta 420cctagtatag ttcctggcat ataatcagca cacaataaat gttagatttt tattgttgtt 480tttacttcta tcttgatgaa aaatgtatta tttttacact gttataaacc taagagaacc 540atgagttagg ttccacaaat ttcattgctg aaatcatgta ccttggacag ttctattat 599529599DNAHomo sapiens 529tcctgcgtct ctgccaggct tcagcccgac aggaccctca cccaagcatg agaggttcac 60aaccttgagg agtttggaag ggcacgcaaa ggggatcgac tgctcttttt taaaaagcat 120actgcagagc tgtttggcca ttttacaaga cttctgatac ccagccctcc tccactgctg 180ttcaggttct aacccctctc cttgcctagc ccctttccag catgagggtc agccttacac 240tagcaccatt gcccgagtgg ggcggggtgg agggagttca ccacgggtgc atgttctgay 300tgatcagagc ccacgctgtt caaggtgcta cctacttcga acatcatctc tgcctgcatc 360cctgtttccc attactcccc agatatctat tcccctacag agagtttgac caccattcct 420cctagaatct tctgtcccag aatgacttac ttttaccgat ccagccccta cccatcctcc 480acaaggctgg tcaagcgtct tttcctcctg gaagccctcc tagatcagcc ccaggccagc 540gtttacctcc attttctagc tcccagaggc tttttcgaac tgcaggtggt gtatcatta 599530599DNAHomo sapiens 530agatcagccc caggccagcg tttacctcca ttttctagct cccagaggct ttttcgaact 60gcaggtggtg tatcattagc aggtcatgga catcaattca gggcattgca atgagcattc 120tttaaccaaa tagaatacaa aatatcagaa gataccgtct gtgataaaga tcacagcatg 180tatatgaaca tacgtatgtg tcgcatactg atgtgatata aaaaacgttc cttactgctt 240cttgcagtca aaacctttga aaaacattgg atattaatgc cttccatcct aaatagtacy 300aagcatctaa aatctgccta acttctccaa agacaccagg agtgaagtca gggagaagag 360aggagagtga gggggtcagc caggctggag ccactctgac atgggagagg aaagtatatg 420aggacaggga ctaggtttct ctacttacct ctcccctggc acctggcata agtgtcaatg 480aatgggtagc acaccagtta ggctagatta ctctgtgata acaaaagaaa tcaaggccag 540gcgcggtggc tcacacctgt aatcccagca ctttgggagg ccaaggtggg cggatcacg 599531599DNAHomo sapiens 531aagtgcagag aacaccagca gggcaaaggg aagtgatcca ggagatgcat tttattaagc 60ctgttacctc agtggatgtc tgaagcccaa tcccatggag aaggtctgga aaatagtgta 120aagcgcacct caaaattatc cccactttag ggttgaggaa gctgaagtct ccctcaaccc 180gctccccatc agcgctgatt caagctgctc ctgagggatg ttagtgcccc agcccttcca 240gcctgctcca ctcactcagg ggagtggagt aaccttccag aaaaatccct cgttcaaags 300caggtgaagt tcccagagca aacttctcag taagggtaag gtctgaggga aatgagcagg 360aaactgacag ccccagcttc cacacaggtg aacttaccag gcaggagaag aaagaggcag 420atatgcaaat aaacattagc aaaggagaaa atgctacaat tgaggaagca acaaagcgtc 480caggcacaga ggaggtagca gctgatcctc ccaaggatgg aaaaagactt cctagaagtg 540atcaaatctg ggctgaatcc tgaaggccaa gtaggagtta cctctgagaa gaggaagaa 599532599DNAHomo sapiens 532agaaaatgct acaattgagg aagcaacaaa gcgtccaggc acagaggagg tagcagctga 60tcctcccaag gatggaaaaa gacttcctag aagtgatcaa atctgggctg aatcctgaag 120gccaagtagg agttacctct gagaagagga agaagagatg caatggggac tgcttgcctg 180cccatcacct ccattgtccc tttcttccca gctgacccag ttctgcttag ggtgcactgt 240gctcagcccc aggtacctct ctaggactgg tctgcacctg ttgcaaaatc cttatgcccr 300tttgccagag tcttggtttt ccagcctctc ttgcacctgg cagtgggcgt gtcaactggc 360cctggccaat aaaggtagta agagggggtt gggtgcaatg gctcacacct gtgatctcat 420ctcagcactt ggggaggcca aggcaggaag attacgtgag gccaggaatt tgagaccatc 480ctagccaaca cagcaagacc ccagatttct tttttttaag gtaataagag ggggtctgcc 540agggaggatt ctgtggcagc atttgctttc ctgagctaaa gagcagatgg atttgctgc 599533599DNAHomo sapiens 533agccctgacc tcaggtgatc cacccgcctc agcctcccaa agtgctggga ttacaggcgt 60gagccacctt tttttcattt ttttctctca cccaactatt atttcaaaac caaagatgac 120gggagagggg aaatcaagtg ttttctcatt gggcattcaa agagtgacca attaaccccc 180caaattaggc aagtaccagg gagacccata aagatgagac attggacttc atgttcacac 240acccatcaac actccagccc taaattatat ttgacattta attaaaaccc caaggcagcr 300aagtcaagag ttgaactgct acagtactgg aaaaggagcc gctctttagg atggattcat 360ttacctcctg ttaccaaagc catcaacact gacctccccc agcccagctt tactcactgg 420tagaaataca acagaggcat gactggggaa gtgtgttccc cgtctcctgc actcccctca 480tcgcctccac agacatactc agacgccatc actgccagag tggaactggt ccttctcagg 540ttccatgcca cccagcacta acttccctcc tggccaccca tacaggaagt cacccaacc 599534599DNAHomo sapiens 534ttccttctct cttctttctt ccttccctcc ttccctcctt cccttctctc cttccctcct 60cctctccttc cctccttccc ttctcctctc cttcacttcc tttcttctct ccttcctttc 120cctccttccc tccttccctc cttctctcct tctgtccttc cctccttctt tcttctctcc 180tttcctcctt cccactttct ttcccttctc tccttccctc cttctctcct tcccttcttc 240cttcctgact gcccacatga tgcactgagc agcctccaca ttctagtgcc atgctaaatr 300ttacaggcac acaaagatcc ataaaacaac tcttgccctt gtgatcttct ggtggagaca 360aagcaattta tgaaatgcct aatatctata ttagatataa taagacaatg tgtgccaacg 420aagagtccag gcaacaggag cttccaggtc agaggaagga gagacctgag tagttagaaa 480ggaccttgct gaggatcagg actcctgctg gacctccaag accgccatga cttagaaaga 540tgagaggaag aggaaaggtg cagggacaga gaacagtaca tgtgaaggtc tagaaacag 599535599DNAHomo sapiens 535agaaagtgtc cttggacccc agacgccact ctcttcctcc gattttgagg catcaaaaca 60aaatgatgct ttcctgatac agatcacaaa cccagcagag aatcaagaca cattagcact 120gattcaaaca cacatgaacc tcactgtctt agaaacagag catttcaaag cctctcaact 180caccttgatc acaatttcat ccccagaaga tttaggaagt aacaaaggca acagcctttt 240caggattaat tctgatccac caggaagaaa ttactgggaa tctgaaatga cagaaaccay 300agacagaaga gacaggatat tagaagaaag tgaacatgtc atcttagact tcagagcagc 360ccagaaagag aatagtagag agacatgtgt caaagacttt agaaagtcta atttccagac 420atttggagaa aaggtagcta caatccagta accagagtct ctacagggga agatatttca 480agaacgaagc gtagcagttt ctggagacaa ggttctgtct acacaattgc aaaatatttc 540actgggggag aaaggagaaa gaaatcttaa aaagataata acaatttcag ctgcactag 599536599DNAHomo sapiens 536catctacatg actggtccag gccctggccc cagctctgcc cagcactagc tatgtgacct 60tggacagcca tgtcctctct caacctcagc atccttatct gaaactcaag ggactgggct 120aggttcttcc agacccttgc agcagtaatg ttctgggagg gatggcttta agacattaag 180cataatatag gccttgggga agcctgagca aatgtgggtg gaggctgggg gagcaagagt 240gttggttgga cacagcccag aacccctcac tgtggtttgt ttgaaagctt ggtaagggcr 300tgttgcaagg agaaaggaca ttgacctagc aaatggggcc tgctggcaga cctgtgctca 360gcacacagag ctcagctgtg tgagagtaca caggagagca cacacacaca cacacacact 420acacacatca catacacaca gagagtcagc ttttggcatg ctcctagctg aggaggaaga 480aactagagcc acagagaggg acagagggac agatagggat accgtttttt ttttgtttgt 540tttttttttg agacagagtc tcgctctgcc acccaggctg gagcacagtg gcacaatca 599537599DNAHomo sapiens 537ctgttctgct tcagttctgc acacagcgaa tcccagaata actgccccca ttttaaaaag 60agaaactgag gcagtctcac taagagcatt ccagcagact ggaagcaagt cggaggcttc 120ggctgctgac aactatctgg gtttcccttt tagtgctggc caggagggag ggagggaggc 180aggcagggag gggagtgtgg tacgggacgg ctcaggtaga gggtggtgct ggaaaatacc 240tcaccctcga tggaggaaaa aaccacagcc aaacagctac gatcagcagg gaggaaagar 300aggaacattc tgggctctga ggcctgtggt cagataagtg gccccaacct gacttcctct 360ccatcctcga tgtgcttttc catttatcct tccccttgcc cataagccag cctccaaaca 420gaggagcatt tgataacatt caagccccac agctctctat tccgagcccc tgtttttttt 480ttttttttag gctggagtga agtggtgtga tctcggctca ctgcaacctc cgcctcctgg 540attcaagtga ttctggtgcc tcagccccct gagtagctgg gaccacagac acgtgccac 599538599DNAHomo sapiens 538aagatgcttt tcacttaact tccagccctg ctgttgacct cactctctgt tttcaatctc 60cacggatatt tctcaatgcg ttgtaaatgt ctctcaaaac gaaactcaca cttgaccaaa 120ctcaggttat ctccctgaat tctgctctct ttaagttcac gctgggaatg gagtccagga 180gccactgaag gagaccaggc ttcctcttcg tagacatgta ccccatgtgt caccgagggc 240cggtggggag agagggagtt ggtgcagttg tctttccgta tgcttatcct gaagcatccs 300tcattcccct taataccctg tcacagagcc atcgtctgcc aagtcaacga agcccctagg 360gaacctgttt ctatttctag cagatctctc aagggctggt gcgatcctat gtttactacc 420cacagtgtga ggagggcctt tctgtgtggc ctaaaactgc ttcccccggc ctctctgagg 480gcccccgttc tgggattcag catgtcctcc ccggccaatg gcaaggggca gggggctgaa 540tcccctgtcc agtcctgttg ccgtgagcca tgtcgggggg actccacaag gcctcaggg 599539599DNAHomo sapiens 539acaaagattt attctctcac agtcctggag gccagatgtc tgaagtcaca gtgttagcag 60gaccagaggc tctaggggag gatccctcct tgcctctccc agctcctggc agctgccagc 120attggctagc ttgtggctgc ttcactccag tctctgcctc tgtcttctca tggccttctc 180ctctgtgtct caaatctccc tgtccttaat tttagaagga cagcagtcat tgaatgtagg 240gcccacccta aatccaggat gatcttacct agagatcctt aatcacatcg gcaaagacam 300cattttcaaa taacttcaca atccctggta ccagaatgtg cacatgtctt tttgggggac 360aaaccatccc actgcactgg tctgctactc attcccttgc aagtgatcct ctctgccgaa 420tttcgagacc cagactcttc tgtgagccat gcaaggcccc cactttcctt agccagccgc 480atttctcata ttccccacag catatccccc accctgccgg cagccctctc actttacccc 540catcaatgtc cttctttctt ttgtaacttt tttttatttt actttaagtt ccgggatac 599540599DNAHomo sapiens 540aagatctctc tgtcttctgc acaggccaaa taggagaggt gaatggggat gtggttggaa 60ttactatctg tccatgcttc aaggcttcac actaatctct gcaatttatc caggatgaaa 120tattgctttt ggtttactat tttcctaagt agagctctca tggcctccaa ttggcctttc 180caccaaaata gctctcactc tgtaggtcat ggaaccaata tgaggattct tccagctgct 240aaatatgtct attccaatta tgcatctaga actggggaaa taacctggat ggtctcaggk 300acccactgaa cccactgtga aatgaacctg agctaaaatt ccattaatca ccttacctcc 360aaagacctct gttaggaaat aaaaaataaa aaacccacaa actgtttttt cctctgctct 420cacatcgcag caacaatcac cacagaagat ccgtgactaa atgtgtgggg atttctcccc 480accaaaaagc aagcaagcaa ttctgtacca actaggtgtc ctccaattca attaattttg 540atgctttcta cctagagata acctcagaaa ccacaagttg agggctcagt ctctaagac 599541599DNAHomo sapiens 541ttgagattca tacgttaaaa actattagtc taaaagctag tattattgtt aactttggct 60tgtaactcct attgacagaa attaaggctg ttgaggcaga aataatttga taaaggttta 120ttggaagcca aatgtgagga tcaacctggg aagacacatc agaaagttgg gagtgttcca 180gaatctgtta caagttggaa ggcttttata agtaagttta ggagaaggga gaggggctcc 240tcatagtgaa gttgtccttt ttcattggag ggtacaacac aaagattggc tgcaaagtay 300gacatacagg gcaacataca ggttaaaatt ctatgcacaa gacaatcagt gaaacttcat 360gattcagaaa caaatcacca aaacattatg attcagaaac aaatcagcag cctttttgat 420gtcagtaggt tataaattaa tcattatacg tcaataattt gagaaactca gataagattc 480tttactcatg aacaggatgt tgccatgaat cacaagactg ccccaagata ggttaattta 540agaagccctg tttactttta aagtaaactg ccaaatatga actgtaggtt atcacccca 599542599DNAHomo sapiens 542tgttgtttaa tttccacaaa tttatacatt ctccatttca cttcggttat tgatttctaa 60ctttatgtca tttggtcaga gaagatactt tgtatgatat ccatctttta aaaatctatt 120gagacttaat ttgtggccta acatatgatg tatcctgcaa aatgtcccat gtgcacttga 180gaaaagtttg tatactgtag ttgttggaga gaggattgtg tatatacctg ttagtctggt 240tggtttattg cattgtttaa gtcttctgtt tccttgctta ttttctgtct ggttgttctm 300accattattg cgagttgggt attgaagtct ccaactattg ttatagaact atctcttttt 360ccctttcatt ctgtaagctt ttgctttatg tgttttgatg gtctgtcctt agatgggtaa 420atgtttataa ttgaatatct tcttgctgtg ttgggtcttt tattaatata taatgtcctt 480ctttgtccac tatagccctg taagtttatt tcgcctggga gcagtggctc atgcctgtgc 540tcctagcatt ttgggaggcc gaagcaggtg gaacacttga gcccaggagt tctagacta 599543599DNAHomo sapiens 543agaattcagg aaagggcaag tggaggaaaa gagaggagag gagaagagaa gagataaaaa 60tatgaaaaag aagtttataa tttagaagat agtatgagaa gagctaatat atgtataatt 120ggagccctag aagaaaggac taaagaaaat gaaggaggga caaatttaat gagataatgg 180ctgagaactt ttagaattga tgaaatacat gagtccacat gctgaggaag catattgtat 240accatttagg gttttttttt ttaaaaagca actcatgatt agatacatca gaataaagcr 300attcatgact agacactgca taataccaaa gataaagata tatttaaagc attgataatg 360aaaagagaga ttacatagaa ataaatgaaa taaggcagat tatgtatttt ttccagtttt 420ttatgatgat aaaatataca taacatttat caccttaccc tttgtttttt tttttttttt 480gagacagagt ctcactctgt tgcccaggct gggagtgcag tggcatgatc tcggctcact 540gcaacctcca cctcccaggt tcaagtaatt ctcctgcctc agcctcccaa gtagctggg 599544599DNAHomo sapiens 544ttcatctctg tttctctctc tatgtcattt acattctctt tcctttttct gaggccatgc 60agttctctac ttctttttac gttttataga agatggctgt cccacagttt atataatcct 120cagtttcagt cacacacggg gactaactga ctgagaaata gaacctgact gatccatctc 180aggcaaatgt accccctgat ccaatcagct gtaactacag gtcaggaaca catagcacaa 240agatggctgt ggacttccca gccctgagga agagaggacc aattctcaga caggaataay 300tgagcaaaaa tatgtcttcc aaacaccctg tcctctcaat ccctgttgtt gtttctgcct 360tcattcatca tttcactatg aatggctgca aacatttcct gacaacttgc ctttcttcca 420gccttttctt ctcaatccac tctctaccag agtgatcttt gtacaatgaa aatcgcatca 480tgttactttc ctaatgaaaa cccttcaaga attctctata acctctatga caaattccag 540acttcttagg ttggctggaa gaagtaattt actaatttga gtcctaacgc ctaatcttt 599545599DNAHomo sapiens 545tgcttattat tcacaacaat cctatgaagt aggtactatt attatccaca ttttgtatat 60aggaaaatta aggcacagag aacttaagta acttgcccaa ggtcagatac tttatacatg 120gtagaggtag gctccagagt ctgcttttga tgattatgca atattatttc tctgaaactg 180gggttaaatt gattagtagc tggttgtgag caaggataag taggaaggtt acattttgct 240gagactttgt gttaaatatg gctaagagca catgttctaa gtcaggctgt ctggcttcar 300atcccacctt tgctacttat cagccctgta gctttgggtt atttgattca cttcctatat 360ctcacttttc tcatctgtga aacagggtta ataacagtgc ctacttcaga taatgctatt 420agcgccaact attaaatact taagccttca gatagatgat aacttttatt agaacacctt 480gattcaccat ggggcaattt tcctgaattg tagaatgact cccacaaaaa aaaaaaaaaa 540aaaaaaaaaa aaaaaacaga aaaaaactgc ctttttaaaa ctcacttagc cttccaagt 599546599DNAHomo sapiens 546tttggttaac ccgtttgcca aggaaactaa aaaataaatt tgaaaaggtt ctttttgtaa 60tgccaaaata tttgttgaac agattgtgag gccacttgaa tcactttagc tcactcctgg 120gctcaagtga tcctgaatga gagttatttt aaagctggag ttactttgac aaagagcatg 180cctctctgac cgctcagctg tgtctcgtct tgcctttgct gaatttcact cactgtagca 240tattacattt gtgaaagatg gaaacgagtt ttcacatgtg aaaaatggct atcagaggay 300gggaaaactt tagtagaagt tgaaagggag ttaacacctg tggcttgaga atatgcacag 360aaaacaggag actctcagtg ggatctatga tttgagggaa ggtcaggtac ctgcctaaac 420atttctatgt tcacaaatat ggacattcat gaccatcttt gaacatgttc atgttgtgtg 480ttaaagtttt attgttttga accatgattt cttattagtt aattaccctc aaactcagaa 540caaaactgat taagttgctc actaacagca tgtgatcact ttccaaatgt gtctttttc 599547599DNAHomo sapiens 547cagtgagtga aattcagcaa aggcaagacg agacacagct gagcggtcag agaggcatgc 60tctttgtcaa agtaactcca gctttaaaat aactctcatt caggatcact tgagcccagg 120agtgagctaa agtgattcaa gtggcctcac aatctgttca acaaatattt tggcattaca 180aaaagaacct tttcaaattt attttttagt ttccttggca aacgggttaa ccaaaaggat 240cttctgtaag tggacaagga ttgagaaaac taaggaattt gatccattga acctattgts 300acggaaatgc agtggttttg tatggaccta aataatttgg gcaacatagc gagaccttgt 360ctccacaaaa gaaaaattga ggccaggcgc ggtggctcac gcctgtaatc ccagcacttt 420gggaggccga ggcaagcaga tcacaaggtc aggagatcaa gaccatcctg gctaacacgg 480tgaaaccccg tctctactaa aaaatacaaa aaattagccg ggcttggtgg cgggcgcctg 540tagtcccagc tacttgggag gctgaggcag gagaatggcg tgaacccggg aggcggagc 599548599DNAHomo sapiens 548gagttccaac agctttgact ttgaattact tattttcaca ataacacaaa caaaacttga 60tataataaat gcatatatcc ttagaattga caatatatat tttatatgac catgatttgt 120acaaaaattg tatttgctgc aaaaaacatt aaaatataaa acagtaaaga tttttaaaac 180cacaaactct gatcctcatc caataaaatc agaaatatat catataaaaa tgaagtgaca 240agagggcaga atagaaggta acccgctcat atctccctat aagaattctg catccatccr 300tggtaaaaag tcactctgca ggagcctcag gattgaggta ggagtttgtg aaaccctagt 360gaagtccaag acatcagagg atcatttgca gagggaagac ctacacatag gtggctgatc 420caccaagctt gttcctgggt tcaagccaga aaatgaccca gtctcccaag gggtttggat 480acaaccccac ttggccttga tcctgcaacc aaagccatct gccgaggagt caagaaggaa 540ttgtgcacac taatagaaag gctcatctac ccactgacag tcgtgttggc agtcaatct 599549599DNAHomo sapiens 549gatagccatc catcttggcc accaggacag tcttctggat tcaggtccct gtccagcatt 60cccacacagc ccaagtaccc tccttgagtc ttcccctgat ccttctgggc tggaaagctg 120tgccaatctc atagtcctca tgagacttgc agcaagcctg tacttagagc atcttctact 180gctgagatgg ctgcagaggt cagaggctca gagaaaacaa tagtcagact gtatagaatc 240cctacaagga taagcacaaa gaaagctaga ctacaaagac taaaatatta aataaatacy 300taacctatca atacgcagac atcatttcat gttcacagca ttaaaaacac acacggaaat 360atgactcttc atatggaaaa actaaggtgc cagaggctga ccctaaaggg atagagatat 420gcactttctt agacaaataa tacaaaatag ctgttttaag aagcttgatt gacttctaca 480aaatacacat aatcaattca gaaatgtatc agagaaattt aacagagatt aaaataatta 540aaaaaaaaaa aacccagaaa tcctggagct gaaaaataca atgaatgaaa ggaaaaatg 599550599DNAHomo sapiens 550atatggaaat ccatgagaaa acactatgct tagtcagggc catgtgacaa tagaatttct 60gcagacagtg acaattaaat tgagatctga aaagtgagaa agatgtatac agattaaaga 120gaggttggtt ggagaaaata tttctgggat agagaataac ccttacaaag gcctggatag 180gagagaacga aagtaagttg agtatggcga aagtacagag caagagctca ggatgaagtg 240tgtaatacaa actgcgaaga aaggctcagc ccagatcagg aaggctttgg aagccaaaty 300taggagcttg gactttaccc tacatgcaat gtgaagacat ggctgggtgt taagtagaag 360agttgcactg gttcttttgt ttcccatacc tccagatcca ttctctgccc tggaaatcag 420atccccatag ggtctgtcac ccactctccc ttgcctactg gcttccagat gggttcagcc 480aatgcggtgc cttttccctg ggtccccttg cttcagtgct acacccgata gtaaatgtat 540ccctccttga acacaggtcc tgccaggcag cccttttgtg gctccagctt tcactgagt 599551599DNAHomo sapiens 551ccttcactag gagaggtaat tttggcaaag taaaataggg atctgtcacc caaagatatg 60gaaattgttc ctgagcagaa aacacacaaa caaaaccagc tacccctgca gtccctgtta 120ccaggtactg ttctctactt tcctccctcc accctataga atatagccta ttctatattc 180ctctgggata atggcttcca ttcttccttc ctgggaattg cagcctaact cttgtcgcta 240gtctggtggc ctggagcttg gtgacccacc ctggacagtc cttctgagcc tcagacctgs 300tatctatata tttattgaat tatctagtta ctttagcttg caacttttga gagtaattat 360taagagcagg ttttgctcaa atgtaaacag aagttttaat gaactttcaa ctctcttctt 420caatcagata aatatttctt ggcatcctct gcaccctgga cagctcccca agtgaccttc 480tgttactcac aatctcttct aatttccatg aaaagtgaat taaagccatg acattatctt 540cccatttggt ctatatcttt ctttaccttc tttcttcctc ccaaagtctg gcccacttc 599552599DNAHomo sapiens 552aaacctgctc ttaataatta ctctcaaaag ttgcaagcta aagtaactag ataattcaat 60aaatatatag ataccaggtc tgaggctcag aaggactgtc

cagggtgggt caccaagctc 120caggccacca gactagcgac aagagttagg ctgcaattcc caggaaggaa gaatggaagc 180cattatccca gaggaatata gaataggcta tattctatag ggtggaggga ggaaagtaga 240gaacagtacc tggtaacagg gactgcaggg gtagctggtt ttgtttgtgt gttttctgcy 300caggaacaat ttccatatct ttgggtgaca gatccctatt ttactttgcc aaaattacct 360ctcctagtga aggtgcaggc cttcccaagg ttaccaattc attttcttcc tttgaatgtt 420gaatcttcag tagatattta aaaatgaaaa atggttagta tgaattcctc tgagctttgc 480agcactcatc ccggggacac tgactcacaa cacagtttat atgaaaagag gggatgctca 540tcatcccctg aagttcaaga cgaggctgag aaacatagtg ggactctgtc tctacaaaa 599553599DNAHomo sapiens 553ctgcaggggt agctggtttt gtttgtgtgt tttctgctca ggaacaattt ccatatcttt 60gggtgacaga tccctatttt actttgccaa aattacctct cctagtgaag gtgcaggcct 120tcccaaggtt accaattcat tttcttcctt tgaatgttga atcttcagta gatatttaaa 180aatgaaaaat ggttagtatg aattcctctg agctttgcag cactcatccc ggggacactg 240actcacaaca cagtttatat gaaaagaggg gatgctcatc atcccctgaa gttcaagacs 300aggctgagaa acatagtggg actctgtctc tacaaaaaaa aaattctaaa aattagtcat 360gcttggtggc acacacctgt agtgccagct actcgggagg ctgaagccag aggataactt 420gaggccagga ggtcggggct gcagtgagcc atgattgcac cactgcactc cagcctgggt 480gacagagtga gactttgtca caaaacataa caaaacaaat aactaaataa caaaacaaat 540aacaactccc tgggaaagct gacttttagc ttaattcctg cccttcaata ttctctata 599554599DNAHomo sapiens 554catcttactg attgtactca tgtgttaaca ttcccaccaa aagtgtaata gtaaatcact 60ctcagttatt aattggtgtt caattagaaa ggcagaattt ctctaggcat tcaaacagag 120agaataaaat ccaaggaggg gcaaaaaggg ccagtgatgg tacccagaat tcaaaagagc 180tatgttgctg aggttgccag catccttttg ttaatgctgc tgctgctgct attgaaacca 240ctgctgctgt tacctttcaa gaggctgaga atttgcacat ttacagaagc tgcaagaack 300tgggagccca tagtcccctt gatgttactg gactcactgc caagacgtct ggatcctgtg 360gctgcctgtg gctactgcca gatccagaaa cagaaaatgg aggataaaat agcttctccc 420ttttgccttc tggtctttct ctgagacctg cctttgggaa aatctaactg gaaactacct 480agttaggaaa cttgggaatc tagtttgtaa atttttagca ccttacaata tagagaatat 540tgaagggcag gaattaagct aaaagtcagc tttcccaggg agttgttatt tgttttgtt 599555599DNAHomo sapiens 555ctgaggtttg gttaagttat ttgcctaaga taacactgct aataggtggg ggagcctggt 60ttaaacacaa gtctgttcaa ttgtactgca tcttactgat tgtactcatg tgttaacatt 120cccaccaaaa gtgtaatagt aaatcactct cagttattaa ttggtgttca attagaaagg 180cagaatttct ctaggcattc aaacagagag aataaaatcc aaggaggggc aaaaagggcc 240agtgatggta cccagaattc aaaagagcta tgttgctgag gttgccagca tccttttgtk 300aatgctgctg ctgctgctat tgaaaccact gctgctgtta cctttcaaga ggctgagaat 360ttgcacattt acagaagctg caagaacttg ggagcccata gtccccttga tgttactgga 420ctcactgcca agacgtctgg atcctgtggc tgcctgtggc tactgccaga tccagaaaca 480gaaaatggag gataaaatag cttctccctt ttgccttctg gtctttctct gagacctgcc 540tttgggaaaa tctaactgga aactacctag ttaggaaact tgggaatcta gtttgtaaa 599556599DNAHomo sapiens 556caccactgac ctggctccat tgtccagtcc cactcttaga ggagaaaggc tctggccaag 60actgttccag aaggataata cctttttttt ggtctctttc ccagatataa gaaacctggt 120gacatttctg cctccaaatt tttgtgtaat ttaagaacag tttcctcctc tgagcttagg 180ttctctgatc taaaatatga gaggtgagag tctttaaagc atcatccact actagtatct 240tataattcta tttcagcata aacatcttta attcccaatc ttttctcatg aagacaccak 300catgacctct tattcttatt tatatctttt ggactccaaa tacttcattt tagagatcta 360gtgctctgaa gggtcaaagg ggcaccttgt gaaaagccat atttgtctct ttacattcac 420catgacttat actaaattat aataagtgtg aaatgtctcc acggacagat acaaaataat 480tttgtatctt ctggccaggg tccggtggct caatgcctgt aatcccagca ctatgagagg 540gcaaggcagg cagactgctt gagctcagga gttttaagac aagcctgggc aacatggtg 599557599DNAHomo sapiens 557caataatgca atctcagctc actgcaacct ccgcctccca ggttcaaatg attctcccgc 60ctcagcctcc tgaatagctg ggattacagg aacccaccat catgcccagc taatttttgt 120atttttgtag agatgaggtt tcactgtgtt gggcaggttg gtcttgaagt cctgacctca 180ggtgatctgc ctgccttagc cctctaaagt gctgggatta caggtgtgag gcactgcatc 240cggcctgaat gttgcataat tttggattgc atcctcaata ttgtgaatga tgtgttgtar 300aaattccgga atctgaatgt tcctctgaat agtactgatt ttaagcatat atttaacttt 360tatagaatga aactgtaaca ctgtatttcc actgtgatga gtgtagctga aattttactt 420caattccttt aactttaact aatttgcttt gagtctttcc ccaatagtca tgttcaagga 480tcactcagag atttgggaaa attttgtacc tagaatatga gacccattgt ttggctctct 540cctttctggg agtttcttct tcactttcca gtggatctag ttccccaaac acaagtcct 599558599DNAHomo sapiens 558aagaagcagg aaaacatgac caattcatag gagaaagatt aatagaaaac aagctaggat 60gacccagatg ttggccaaca attatttaaa actgtatatt aaaatgatgc tcagtagtaa 120aaaggaaaat atgctcacag ctaataaaaa gtgggaaatt tcagcagaag aaaagagatt 180atttttttaa agcccaaata gaaattctag aactgaaaaa caaaacagct gaaatataaa 240attaactggg taagcttaag aaccaaatgg aatgatggag gaaagaaaca atggacttam 300aagtcaatag aaattatctg atttgaagaa ggcagagaaa taaattttaa ttaacagagc 360ctatggatct gtgagacaat tcaaaactga agacctgaaa gaagacgaga gagagaattg 420agaggaaaat catggcccaa attccctaaa cgtggcataa aacatatagt tacaaattta 480tgaagcttag acagaattag tagaaaaaac actcctattt acatcataat caaactatgg 540aagaaaaata tttgaagaca aagaaaaatg acacattgaa tacagggaaa caattaaaa 599559599DNAHomo sapiens 559catggcagta ccaatgggag caggaatgcc tggcctcaat aacaatagga gccagaaacc 60acacatgtat ttactaaaat gtctttcaag agggcacacc tgtaagtctc tgcattttgc 120cacttataca acttcatctt tgagcgctta catagggtca gattacctaa caatagctgt 180aagccaagac aaaattggag gaggagagaa ttagtagata cctgatacag gatataaggg 240ctaagcttta gatttttcta tcctgactcg atccagggta tttggtttct attgtttttm 300actaaataaa gataggtctt tcaacaatcc cagcttctgt ggaattagct gaaaataaac 360caagagctag agactcaaag tatttacagt agatacattt gagtaggtat attgctcaag 420tcacactgta actgcccagt gggttcattt tgcctgctgc ccagataaac tcaatttatt 480aagacagagg aattgtaata gacaaagagt ttaattcatg cacagccagc taaacagaag 540acagaaaatt cagagattgg agttttttaa gggcaatttg gccggtaggg ggccagaga 599560599DNAHomo sapiens 560tgggaggtgg agagtgggcc tggaggggtg cacagaggca tccagccaaa aggccagggg 60tttccttttt taggctactg ccctcagcag tcatgtctct ctgagggcca ggaatctaga 120ctgaattgaa gctggcgaca taatccctgg gtcactcatg tctttctaga gtgacactgc 180ctcctggagg aaatccctga tggtgcctca tttttatttc tttttttttt ttacatcctc 240cgtgtccagt acctgctcat aggagacaca gtaaagatat aggtgttgac caagtgcacr 300tggaaaacac attgttgttc tgcatcagtg attttaatta aaaaatacgc ctctgaaaga 360aagaaagctc actggtttgt agtcctttaa acaaagtaat gtgatattta gttgaggttt 420aagttattgc accacgtctc tagtacagtt cagtgtcttt ctatttttag acaaaggtaa 480accttatttt tgtttccttt cagaaggggt atatccactg agaccagagg ccaaactccc 540tttgtacttt tctttttatt ttattttttt tgagatggag tcttgcttca tcacccagg 599561599DNAHomo sapiens 561ttcagtgtca tcagtcattg gggaaatgcc aatcaaaacc acagtgaaat gctacttttc 60acccactagg atgcatgtaa ttttttttta aaaaaaaagg aaaaataact attgttgagt 120atgtggagaa tatgaaacag cttttacaaa aatgtccact taaaagtaat tttttaaaat 180tgaggtaaaa ttcacatgat ataaaattaa ccaatttaaa atgtacaatt cagtagcatt 240tagtacattc acaatattgt gtaacattac ctgtgtctag ttccaaacag tttcatcacy 300ccaaaaggaa atcttgtatg cataaagcat ccattcccca ttttccctta cctctagccc 360ctggcaacca tcaatttgct ttttatttct gtggactgtc ttttctggat atttcatata 420aatggaatca tacattatgt gatattttgt gtctggcttc tttcacttag cataatgttt 480ttattcatgt tgtagcaagt atcagtacct tattcctttt tatgtctcaa caatattctg 540ttatgtcaat ataccacatt ctatttattt attcataagt tggtgaacat tttaattga 599562599DNAHomo sapiens 562cattaaaggg tgacagattt tgtcaaaagc tttttctgca tctattgaga taattatatg 60ggtggggttt tttccttcat tctatgggtg tgatttatta cattgattgg ttgttatatg 120ttgaaccact cttgcatttt tggtataaac ctcacttagt tatgacatag aaccttctta 180gaatgttgct ggatttatgc agcagttctt atagggcagg tctactagtg atgaactccc 240tatgttgccc tgtttttctt tatctgataa catcttaatt tcttaatgtc ttacttacts 300tctcattttt aaagaatagt ttttccagat atagaatttt tggttgacaa tgtttttctc 360tcagcctttt aaatatgttg tcccactgtc ttctggcctc catggcttct gaagagaaac 420tagctggtaa tcctacacat gagtatccct tatacatagt gagaaacatc tcagttgctg 480ctttccagat ttgctttttg tctttggctt ttaaccgttt ggttatagtg tatctcagtg 540tgaatctttt gagttatcct gcttggagtt cattgagtat ttcgaatgtt taaaatctt 599563599DNAHomo sapiens 563tgtctttggc ttttaaccgt ttggttatag tgtatctcag tgtgaatctt ttgagttatc 60ctgcttggag ttcattgagt atttcgaatg tttaaaatct tggttactaa tcaaatttgg 120gacattttta ccatcatttt gccaaatatt ctctctgttc cattctctct cctttcccta 180taggactctc attgtccacc tgttggcatg cttgatgatg tcctacaggc cttttagact 240ctgctcattt ttttcccatt ctttttgctt tcttttcctc ggactggacc atttcaattr 300acctatcact ggttcttgct tctgactgct caaatctgct actgaatccc tctagtgaat 360tttttatttc agttattcta cttttcaacc tcagaatttc tatttggttc ctttttataa 420tttatatcta ttatttctat tattgatatt ctctatttgc aaagacataa ttttcatggt 480ttcctttagc tctttaaata tatttaagac agctgattta aaggctttgc ctaataagtc 540atatatctgg tctttctcaa gaatgattac tgtcactttt taaagtccat acttcattg 599564599DNAHomo sapiens 564ttccatgcaa gcaggaagtg aagaccaaag cagagttgta aatggctttg ctatgcgttg 60aaggcatgtc ccaacacaga gccaatctga aaacactagg ggaataattt ttctttttct 120ttcttcagct tctatttttg gctctagttg tttaaggaaa tcattgtcat aacactagct 180gaccactaag ctaatggaac accgacttca gtgaccacac ataacaaaga atacagactg 240tagaaaaatg ttttagaaaa gtcactaaac agacagataa caacaaccca ctacaagcar 300caacaacaaa ccatggggat gtggagaact gaatttcctg agttactgta ttataatgtg 360caaaatgtcc acctttcaac acaaaattat gagacactca aacaatgaag tatggacttt 420aaaaagtgac agtaatcatt cttgagaaag accagatata tgacttatta ggcaaagcct 480ttaaatcagc tgtcttaaat atatttaaag agctaaagga aaccatgaaa attatgtctt 540tgcaaataga gaatatcaat aatagaaata atagatataa attataaaaa ggaaccaaa 599565599DNAHomo sapiens 565aatgattaat aacattcttt tcattctcaa aaatttatga ttcagataac aaattatacg 60attactagaa taaagtctgt atgacctaac ccttagtcgt cctgccttct agagccatgc 120tttcatcttc attcaactag ctacttgaat agcatggagt aacttgtggc agtccaatat 180taccattgag tacaaccaga aaggcagatc aggagagagc tgctgaagca cgaaggatga 240ggggctaaga ttccatggag agattagcta acagtagtta gctacttttt aatagttacr 300agagcattgg ccaaggcagg gaatctgtat tttaccaagg taggaggtca ctgccaggag 360acagagaaat cactgttgat cggtgttgtg ggaatgaaga gacaaaattg gaaattggaa 420gggccaggcc cccagcaaga agagagggct ggagaactga acctacatat aatgagtttc 480ctcttcaaaa cacttgccga attacgcagc tgcatggggg caaaggcaaa aaaaaaaaaa 540aaaaaaaaaa aaatcagcct cttaaaagca gagctgtggt tttagcagcc tttttggtt 599566599DNAHomo sapiens 566tgacctaacc cttagtcgtc ctgccttcta gagccatgct ttcatcttca ttcaactagc 60tacttgaata gcatggagta acttgtggca gtccaatatt accattgagt acaaccagaa 120aggcagatca ggagagagct gctgaagcac gaaggatgag gggctaagat tccatggaga 180gattagctaa cagtagttag ctacttttta atagttacga gagcattggc caaggcaggg 240aatctgtatt ttaccaaggt aggaggtcac tgccaggaga cagagaaatc actgttgaty 300ggtgttgtgg gaatgaagag acaaaattgg aaattggaag ggccaggccc ccagcaagaa 360gagagggctg gagaactgaa cctacatata atgagtttcc tcttcaaaac acttgccgaa 420ttacgcagct gcatgggggc aaaggcaaaa aaaaaaaaaa aaaaaaaaaa aatcagcctc 480ttaaaagcag agctgtggtt ttagcagcct ttttggtttt gttcttgttt cataaaaagt 540caagagttat agttcatgac tgctgggaga aaattgaata atttttagaa attgtttca 599567599DNAHomo sapiens 567ctccatatat atatatgttc tccatatata tatatatata tatatatata tatatatata 60tatatatgtc tacatcagaa aatttatatg tcagtaaatc tgataccata agggtttttc 120tggagatgtc agtcagactg tgccaaaatc aatgtatctt tcattcaagt tgaaattttg 180gcaaacatgg tggaaatcaa gaggttcatt ggaattcacc ttctttgtat ctcagtttgt 240agcaggaaca tttagaaaca ttaagaccaa atataaactc ctgaaacagc agaaagaaak 300ggaccttaat tctatcaaca acaaaatgat tgggttgggt tcaagaactt caggaaatca 360tggtagaacg tctaatctct tcggtttcct gtagattctc tggtgctgat gtctgcaagc 420aaaagtaact tttaagggga cacaacctta gtgggcctca aaaagttcag gcaaagttca 480gtatgcaggg agtggtaagg gggagtgagg aattgggggc gcttcctccc tatagcggac 540tcctggcaca tgctgctcat gttattatcg gtagattaca gtatacctac gaaggtatt 599568599DNAHomo sapiens 568tcattgctgt tgtcaccctt agtgactgct ttgactcttt aacactcctc agcagttcac 60ccaaaaaatc tcattctgac caccatcatc atcagaacat ctttctctct aagataagga 120acactggaat tcttctgttt atgaacaaac tcccatcttt ctacttcctc cactcccatt 180taaaaaattc ctttttgaac cattttttaa aattgtggta aaacatacat aatataaaat 240ttaccatttt gaccattttt aagtgtacgg ttcagtggca ttcacattgt tgtacaaccw 300taaccactct ccatctccag aacatttttt tcatcttcca aaactgaaac tctatgctca 360ctgaacaata acaccacatt ccaaagttaa ttctttttta tattctctaa ggatctgttt 420cagatttttc ccacttatac ttaaaacttc aaaccaatgc ttatttctct taatctccgt 480ctctttcaga acctacatta caaagattga agccatttta taagaccctt aagttcacat 540ccctagacct taaaacttca catcttctct cattctctca ctagttcctc ctctactgc 599569599DNAHomo sapiens 569caaccataac cactctccat ctccagaaca tttttttcat cttccaaaac tgaaactcta 60tgctcactga acaataacac cacattccaa agttaattct tttttatatt ctctaaggat 120ctgtttcaga tttttcccac ttatacttaa aacttcaaac caatgcttat ttctcttaat 180ctccgtctct ttcagaacct acattacaaa gattgaagcc attttataag acccttaagt 240tcacatccct agaccttaaa acttcacatc ttctctcatt ctctcactag ttcctcctcy 300actgcaggaa gaagtgtgcc tcctcctttt caaagctgat ccttccactt gtgttctttc 360cccctctctt ctgtatctcc tctggaaata ttatgtaagt tttcctcttt tcattggcta 420ctttctttct gcattgaagc atactcaaga gtctatcaca tcccaatata aacctcaata 480ttaatgacaa taataataac aaacatattg agtctctact gtgcaccagc tactgtgcta 540agcgctgaaa atatatcttc tcatttaatt ctcacaacaa cctaatgagt taaattatg 599570599DNAHomo sapiens 570gccaacatgg tgaaacccca tctctataaa aatacaaaaa aaattggcca ggtgtggtgg 60catacacctt gtagtcccag ctacttggga ggctgagaca gaagaattgc tttaatctgg 120gaggtggagg ctgcagtgag ctgagatcgt gccactgcac tccagcctgg gcagcagagg 180gagactctgt ctcaaaaaat aaataaataa ataaaatgaa agtgctacag ctaaaataat 240ctctgtttag gatctgacgg taggaaaaag ataagctccc acacgttcta atgcatttaw 300gtagctccat ctgcattgcc tcatacatca atactgtcat ccaatgttgc ttaatccatg 360tgtgtgtgtg tctatataag tagaactggg atgtaactgc cttaaatact acaattgctg 420actacaggaa acctcatcat ctgagaccag cactttataa attaggtgag tatcataacc 480agtgtgcagg gatatctgct gtatatcatt gggaatagca gcaaaaaaga acaagtgatg 540ttcctattgc catatgttct gaaatatttc tgatataaaa ataggggagt aatgagtca 599571599DNAHomo sapiens 571tgatataaaa ataggggagt aatgagtcaa ttttagtatg aaaaaaatgg tgaaaagagt 60gatcaaggca aagaatttgc aggttatttg aagaaaatac tttttcagaa taggatttga 120aaatatttcc tgactatgct tttgacttat catgtggttc tataaagggt gttgactttc 180tctgtgtcaa tgactccatt gtaaatgtgg tattttcagc ttctctatct tgctcaatta 240tacaagccaa tactggttta cagcaaagtt cttccaagtg cgttctctca aactagtccm 300tgagggtgat aagacgggag aaaaaggtta tgagatcaaa taactactga aaacaatagt 360taaacaaagg tacccatgag tcttcaataa aggactatca acaccttttc tatgctaaca 420tgactctgac tctcctagag atagaatgta gattggaaca tttcccatat ttatttgaaa 480atataacttt ttgttaaaat attctaagat tattaaaaaa agtaactttt ttgaatgacc 540aggaattgtt ttttctagga tataagtatc tttgggtaga agagaaaaca aacaacgtc 599572599DNAHomo sapiens 572taacataatg tatctactta tttgctctat actaaagtat aacaaaacag tctcagaact 60tcagtaccag tatttccact atctacaaaa agagtccaac tttgtaaaat agttgaagag 120atttattctg agccaaatat gagtgaccac ggcctgtgac aaagccctca ggagatcctg 180agaacatgtg ctcaaagtgg ttggtgtgca ttttggtttt atgcatttta gggagacatg 240agacttcaat caaatacatt taagaaatac attcatttgg tccagaaagg tgggataacy 300tgaagcgtgg ggtggagggg ttcagctggg agatgggtaa gggataaaag actacagtca 360actgggatca ataaaaagga atgtctgggt taaaataaag gattgtggaa accaaagttc 420ttatttgcag aggaagcctt caggttgtag gcttcagaga gaatagatta taaaatgtca 480attctaatac agtggtattt gtgtatctaa acatatctaa acacagaaaa agtaaagtaa 540aaatatggta tgaagattta aaaatggtgc acttgtattg ggcaattaac catgaatgg 599573599DNAHomo sapiens 573tgaaccaccg cacttggcca gaaagcatgc aattttagga tctgtttttc atatgggagt 60agtaacacaa aagtaagtta atggagcctt ggtgaacagg aaagaaaatg gaggataagg 120aatgatggtg gggactggca taaccttgtc cttcatgctc ctttccattt ctctgtacat 180ctttaaggct agaaaagaaa gcagagttaa tatcatttct gtctcattct gtcttccctg 240aggctgtggc ccacccacac tgttctttgg tgaccaggga aagcactaat ttgactgtgs 300tttctgaaca accaggaaat cacagcagaa ccaatccttt tacttgtagc tgagtcaaaa 360tgctctctgt agaaacagtg actcagtgac tttgcatccc taaattgcct ctcataaaaa 420gtacattttc tttgtacctc aggaagtatg ggctctttat agaaactgga atgagggagt 480gggctagagt ttatgccaga gttggtggta ttgatacaaa agttaaaatg taacccctcc 540tttaagggaa cagtggccct aactacttac ctataccatt tagaggacag tgataaaaa 599574599DNAHomo sapiens 574aaaagataat taatattcaa acacacatat ttattagcct agcatgctaa aaatatgtga 60gctgtgggtc ctaggtacct caggacagct gattacagga acactcctca cagaaggaag 120ggacagaaga aaatgcacag ggacttttag gaagataagt tggactggag gtcagagact 180gacccaggga tcatccatga gtgtcagtca cctatcctgg atacatgtgt aaatttcgga 240tctctacctg agttggaggc tgctttaaag ttgtctcaaa tggattcctc tccaggagas 300atgcctgctg agaactcaaa agaacgttcc tgataatttc taaaagattc aatccttaaa 360acttgtttcc aaacagactt ataaggaagc tgatttttga ggcagaggcc ttaaaagtgt 420catatacaag tggcatcatt ttaagtccaa agtgaaaccc ttgattttaa taagctagtt 480tattaactaa agctgttttc ttatgttaca gtatttcagc acatttcatt caacataaaa 540agaatattaa atatccctgg ttgtgggaga gtgtttattt ttctcaaaat tatctagca 599575599DNAHomo sapiens 575tatcatcata tgagtggtat tatccacttg tattataact cactattatg ctctttgaaa 60tgtttattgc catttaaaaa aatagcctaa atcctgaaag aagcaggtgt cttcagagag 120aaaagagtaa taaacggtgg taagcataat catcttgtat gcctccatga ctctgtgaac 180tcacctctag agaggtgcct gccttctgca agtcactggt ccctgccctc tcctacaggt 240aggcagtttg gaaacctgcc ccagctgctg cagtcatatc agacttgttc tctggcttay 300agccatgaag acacaaccac agccttcatg gtattctcca ctcctgatct tccagcttaa 360tatctggact aacaagaaac ttaggactct gaccagatgt aaaattaaca tgttttggaa 420gcggcagagt aatgcccaac caacttttcc ccaacatggg gcataaacat tgtaacatcc 480agtccaaatg tcaatccagt tttctcagag ataactgctc taatataaga atgtgtgctt 540gtacagagtt tgtgatgtga atatgtaaat tttatttatg ccataatctc actacagta 599576599DNAHomo sapiens 576cagagctgga agaggcaaga agctctctcc ctgagagcct

ccagagggaa tcaaccctgc 60tgactcttga ctttaaactt ctggcctcca gagctgtgag aaaacacgtt tctcttgttt 120taagaccccc agtttgtggc aattaattac agcaaccctt ggaatctaat atattgacca 180ttccaaatgc tggggaagaa tgtggaggaa ctggaactct tgtacattgc tgatgggaat 240gtaagatagt acaagcgctt tggaaaccag tttggcaatt tttttaaaaa agttaaacas 300ctgctgcagg atccagccat tctgctccta ggtatttacc caagagaaaa gaaagctgtg 360gtaggcaaaa taatggcccc tgaagatgtc catgccctaa tccctggaac ccataaacat 420gttaaattac atgacaaagg agacttttta gatgtgatta gattaaggat cttgagatgg 480agagattgtt ctggattatc caggtgggcc tgatgtcatc acaagggtcc ctataagtga 540aagagggagg cagaagagtg agtgtgagag tgacatcatg tgacaagact tgacttgtc 599577599DNAHomo sapiens 577catgtgttta tttgccatct tgtttggtga aatgtctgtt caaatctttt gcccattata 60aaagctgggc tgtttatttt cttattattg agtcttgaga gttctttatg tattgtggat 120acaagttttt gtttttcttt aattcagatg tgtaacttgc aaacattttc tctcagtcca 180tggctcacat ttccattctc ttaaaagagt tattcaaaga gcagaaggtt ttaattttga 240tgaagatcac tttttcaatt tttttatggc tcatgctttt gatagtgtgt ctaagaacay 300cccgtttgcc taacccaagg tcacaaaaat tttctttttt tttttttttt tgccattgat 360ttatctttat tatagtttaa tggaacaatt tgataagaag acatatctaa tatagcttag 420atgaacagct tatacaggtt cagtatccct tatctgaaat actttggacc agaagtgttt 480gggcagattt tggaatattc gtattatgct tatcggttca gcttccctaa tctgaaaatt 540aaaattcaaa atgctgcagt gagcatttcc tttgaacaac atgttgggcc tcaaaaaat 599578599DNAHomo sapiens 578attcccaaac gttcttctag tactttgcca ctctactgtc aagaggtaag agtcgctgtc 60ccctctcctt gaattggggt gagtttggga ttgcctggag caatagagta tggtggaagt 120ggcttccatc cataggtgac ttccaaggct aagtctgaaa agatggtgcc gcttcctcct 180tgtgacctag aaaactcact cttgaagcct acagcctcca tgtaagcaat ttggccaacc 240tgagactgcc atgttgtgag gaagcccaaa ctagcctatg cagagtgact gcacagagar 300cccggagact ccatgcagag agagagaggc tcaggaacac ccagctgccc cctgctagcc 360cagcaccagc tccatttgac tgtaactgtg caagaggctg tgggccagat ccaggtatca 420gagacctcgg cagggccttg gacatactaa aagcttgtag agtcctgaga aggatgttag 480tgccgaatta agaaaaacgt tattagaaac tggaagaaag gggatctttg ttatgtggtg 540gtggaaagtt tgtcacctgc ggtaacatag aaagaagaca tgtatccagt gaactcact 599579599DNAHomo sapiens 579tttgcaaaat ttgcaccaca catcctttaa atcagtaaaa ttcatcacac aaaaaagtat 60gtatgtacat gcatacatgt atacattttt taagagatgg gagcttgcta tgttgctcag 120gctggtctca aactcctggc ctcaagtgat cctcttacct tagcctccca aagtgctggg 180gttacaggca tgtatcacta tgcctggcct acaatttttt taggacagct ggttgctact 240agcctgccac tgatcaaaac ccaccactga aagaatgaca gttttcattt actgagaagk 300tcgtgaatgt tggaaaataa taatagctaa tattcattgt gtgctgttct aagccctcta 360catgtctcat cacatttaat cctcacaaga gcctgcgagg tgggtactat tattaatacc 420attttcaaga tcaagaaact gagacacaga ggggtagaat aacttgccta aggtcacaga 480gctgaaaaat gacagaacca ggatttaaag tcatgaagac tgaatccaga gtctgtgttc 540ttagctcctg ctctgtgctg tttctccaag ggtaacgtgc tatcttggaa aggcataaa 599580599DNAHomo sapiens 580tttgtgcagc ccttaaaacg gggctctgct tcatcgaatc tcagttttgt gaagctctcc 60tgctgagccc ggcctctgct ccagattcat ccgtatgggc agacctccta aagacaggtt 120cagtccaagg acaggttcga ggtcgaagat ggggttcaga gctctctctg agggcccatg 180ctctctagtt tcctatttgc aggcacacct tttatgaaca gcttggttct gggctaaaaa 240tgcgtgggaa agagctgagg ccctaaattc aggcagacct ggcttcaagt gctagcccar 300caataactgg cctggtgact tgaacttctg tgggtctcat tttcctgtcc tgtaaaatgg 360ggatagtagc agaaattgta tatttggaag ttaaatgaca gaacatgcaa atctcttagc 420acagagcctg acacaatgaa agtaattcat ttttttaaaa tagctttttt tttttttttg 480agacagggtc tcgctttgtc acccaggctg gagtgcaatg gtgcaatcac agcatactgc 540agcctcaacc tcccaggctc aagcaatcct cccacctcag cttcgtgagt agcagggac 599581599DNAHomo sapiens 581ttgctcctca tagggaggct gttggagaga gagagaacac ggaaggctcc gggtggattt 60gtgcagccct taaaacgggg ctctgcttca tcgaatctca gttttgtgaa gctctcctgc 120tgagcccggc ctctgctcca gattcatccg tatgggcaga cctcctaaag acaggttcag 180tccaaggaca ggttcgaggt cgaagatggg gttcagagct ctctctgagg gcccatgctc 240tctagtttcc tatttgcagg cacacctttt atgaacagct tggttctggg ctaaaaatgy 300gtgggaaaga gctgaggccc taaattcagg cagacctggc ttcaagtgct agcccaacaa 360taactggcct ggtgacttga acttctgtgg gtctcatttt cctgtcctgt aaaatgggga 420tagtagcaga aattgtatat ttggaagtta aatgacagaa catgcaaatc tcttagcaca 480gagcctgaca caatgaaagt aattcatttt tttaaaatag cttttttttt ttttttgaga 540cagggtctcg ctttgtcacc caggctggag tgcaatggtg caatcacagc atactgcag 599582599DNAHomo sapiens 582acccggagcc ttccgtgttc tctctctctc caacagcctc cctatgagga gcaactgtag 60ggaccgagag acaatagcag gctgggccat ggggagggat ttttttcccg ggatctcagt 120ggagatgggg aggtagagtg agggaaggaa gcagccaggc agagaggcgc ggggctttat 180taattaattg agggagagac gtaatggagg gtggaatcca cagagggaaa gcgggctcca 240tctcgagttt atgggtcatt tttctggtgg cagttcagtt gccccagaga ggatagcacm 300tcggtctgtc gcctcctgac aagcactagg ggccctcaag gcaagtggga tgtaccccac 360ttctggcctg caatagaaag aactcccttc ccggattcca ggcgcgctgg ctttggccac 420gtggaatggt catggtgggc tgcactggga accacattgc aggttcgaat cccaactgca 480ctgtgtagga gctgcgtgac cttgagtgaa ttggttgacc cttctgtgcc tcaatcacct 540cccctgtgaa gtgggaacaa cagtaccttc ctcgtagagt tgggacgagg attaaatgc 599583599DNAHomo sapiens 583gcagaaaact caagattgga cagtgacttt ctcctaggac actatcttgc cggtgccctc 60acctcagtct ccaccctgga tctccgattt tgtccctgaa acttcaaatt cttttccttc 120aattatacaa tgcagcagct ctcctttcag tagtgctact ttgtacccta ccctggggaa 180gaggtagctc atattcgaac ctgagctctt ggcaaggtct ttttccagat ctaaggcagt 240tcccttccta agggagagtc agatgccact gaggagagag aaaggtagtc ggagggaatr 300ttatggcaga cactgtggtt gctcactaat gtaacatccc ttctcttctt ccttgctgta 360aggactctaa tcttgttccg ggatttaagg aaggtgggtt cagcctctgg cttagaggat 420gggcatgtaa cccagtctga ccagcaaggt ataaaggtca atttatgggc agtctgggaa 480agtttttctt ccccgataag aggaaaacat aaggggatct ctctgctcta agcctccaat 540tacttccttc tccaaaagca gttatgtgag gatgtgatgc ctggagctgt ggaagccat 599584599DNAHomo sapiens 584tcgaacctga gctcttggca aggtcttttt ccagatctaa ggcagttccc ttcctaaggg 60agagtcagat gccactgagg agagagaaag gtagtcggag ggaatgttat ggcagacact 120gtggttgctc actaatgtaa catcccttct cttcttcctt gctgtaagga ctctaatctt 180gttccgggat ttaaggaagg tgggttcagc ctctggctta gaggatgggc atgtaaccca 240gtctgaccag caaggtataa aggtcaattt atgggcagtc tgggaaagtt tttcttcccy 300gataagagga aaacataagg ggatctctct gctctaagcc tccaattact tccttctcca 360aaagcagtta tgtgaggatg tgatgcctgg agctgtggaa gccattttgt gaccatgagg 420agaaagccaa gagaataaca gagacactat cccaatgtcc tgagtattgt tcagctatga 480aactaaccct ggaaactcct tgggccacat agtagatatt ttaagttttg ccagccatat 540gtctctgtca tgactactaa actcttcatt tatatcgtga cagcagcctt tgacaatat 599585599DNAHomo sapiens 585ttacttcctt ctccaaaagc agttatgtga ggatgtgatg cctggagctg tggaagccat 60tttgtgacca tgaggagaaa gccaagagaa taacagagac actatcccaa tgtcctgagt 120attgttcagc tatgaaacta accctggaaa ctccttgggc cacatagtag atattttaag 180ttttgccagc catatgtctc tgtcatgact actaaactct tcatttatat cgtgacagca 240gcctttgaca atatgttaac aaatggatgt gactatgttc tgagaaaact tcattttcar 300aaacgggcta agggccagat ttgccctgtg tgccactgtt tggcacaacc tgtatttttg 360gccatattag ctggatttgc agttacttgc actcaaagca tttctaacag agcatgtatg 420ggctgcccta gagggcagtc tctcacccca aacacagctg tgctcacagg ctcaattgcc 480acttgctgga agcaacagct tattttcttc tgtctaccaa cattcattca ctcaacaaac 540gtctattgag tgcctactct gtgtcaggaa ctgttctgat gctggggcta aaataggag 599586599DNAHomo sapiens 586ttttttttgt ttgtttttga gacagagtct cactctgtca tccaggctgg agtgcagtgg 60cgagatctcg gctcgctgca acctccacct tccaggttta tgtgattctc ctgcctcagc 120ttcctgagta tctgggacta taggcacccg ccaccacgcc tggctaattt ttgtattttg 180agtggagacg ggctttcacc tggtctcaaa ctcctgacct caggtgatct gcccgccttg 240gtttctcaaa gtgctgggat tacaggcatg agccactgtg cccagcccag aaagtattty 300tgaggccttt gtgcagtggc tttatcagaa acaaaggagc aaaaaataga caggagcttg 360ggctcctacc tcataatcaa gttttgcctt gcatttgtcc cagaaaattc actggattaa 420ttggacttca gcacaattgt cttaatttat agcattaagt aaaatctata tatgtcaaga 480tgcaaagtgc aggaatgtaa tggggactgt cacagaggct gctacatctg cagtattctt 540tcctaactgc ctaagaccat gggggaggac atggtctaag agctatgcag gaactagga 599587599DNAHomo sapiens 587ttattggcaa gagctgtgtc ttaattaccc ccagctgcaa gggagtttaa gatggtgaga 60gtttttcttt tttttagctt ttcagcctgt atagtagaaa gtcaagataa aggaggttgg 120gatgggtgtc aagtggtcag tatccaccat ggtccccgtt ccctgtccca cctctcctta 180tcctgagttc tcactctcct gaagtaattc tcttcctcca tttttctaaa taaaatgttt 240attctgtaat ttcttgattt tttcctccat tcagatactg attgtctctc aactatgaar 300ggtaaagata tcttccctca tcactatccc cacatgccac gcacatgcca cacacacaca 360cagtcttcac cacttcatat tccaagtata gattggtgcc atttaaattt ttaaattata 420ttttatttct actttatgtt taatatttta aaattattta agtgacaaac agtaccttag 480gtgatcaaga tcaacatcaa tagtgataaa acatgttgat aatatatgta ccattggtat 540gatgtaatga aaatggcacg ttaccattgt gatcttcctc ctaaacaccc acaacttag 599588599DNAHomo sapiens 588cattcagata ctgattgtct ctcaactatg aaaggtaaag atatcttccc tcatcactat 60ccccacatgc cacgcacatg ccacacacac acacagtctt caccacttca tattccaagt 120atagattggt gccatttaaa tttttaaatt atattttatt tctactttat gtttaatatt 180ttaaaattat ttaagtgaca aacagtacct taggtgatca agatcaacat caatagtgat 240aaaacatgtt gataatatat gtaccattgg tatgatgtaa tgaaaatggc acgttaccay 300tgtgatcttc ctcctaaaca cccacaactt aggctaatgg tgagaaaaac attagacaaa 360ccccagttga aggacattct gtaaaatact tgatcagtac tgttcaaaac catcaaggtc 420atcaaaaaca aggaaagttt aagaaactgc cacagtcaag aggagcctaa ggaaatacat 480acaaataaat gcagtatgga ttcctggatt gaatcttaga acagaaaaaa atcattagaa 540gaaactaagg caatcttaat cacccatgga ctttagttga taataatgta ttgagattg 599589599DNAHomo sapiens 589aacttaggct aatggtgaga aaaacattag acaaacccca gttgaaggac attctgtaaa 60atacttgatc agtactgttc aaaaccatca aggtcatcaa aaacaaggaa agtttaagaa 120actgccacag tcaagaggag cctaaggaaa tacatacaaa taaatgcagt atggattcct 180ggattgaatc ttagaacaga aaaaaatcat tagaagaaac taaggcaatc ttaatcaccc 240atggacttta gttgataata atgtattgag attggtccat taaatgtaac aaatttcacr 300tcagatagta atgtcagatg ttagtgatgg gggaaactgg atatggagca tataggaact 360ccctaaacta tattattaat tttcctttaa acctaagaca gttctttaaa aagtctattc 420aaatattgaa ttaatatttg atggttatat tatgatgatt gggttttgtt gttgttgttt 480tcttgttgtt ttgagagaca gggtctcact ttgtcaccta ggctacagtg cagcggcaga 540atcatggctc actgcaggct tgacctccca ggctcaagca atcctcccac cacagcctc 599590599DNAHomo sapiens 590cacccatgga ctttagttga taataatgta ttgagattgg tccattaaat gtaacaaatt 60tcacgtcaga tagtaatgtc agatgttagt gatgggggaa actggatatg gagcatatag 120gaactcccta aactatatta ttaattttcc tttaaaccta agacagttct ttaaaaagtc 180tattcaaata ttgaattaat atttgatggt tatattatga tgattgggtt ttgttgttgt 240tgttttcttg ttgttttgag agacagggtc tcactttgtc acctaggcta cagtgcagcr 300gcagaatcat ggctcactgc aggcttgacc tcccaggctc aagcaatcct cccaccacag 360cctcccaagg ttcagggatt accggcatgg agccaccatg cccagcctga tgattgttta 420tattattcac aactgggcca cttcgtgtgc tatgactata acattttgtt tttcctagag 480ttagccattg cctctttttt tttgtcttct gtgttcttat caataactca ccccaggctc 540tctgctattc ttataaatct ctcaatacat tcaagaacac tgagtaattt atcagttta 599591599DNAHomo sapiens 591gagcatatag gaactcccta aactatatta ttaattttcc tttaaaccta agacagttct 60ttaaaaagtc tattcaaata ttgaattaat atttgatggt tatattatga tgattgggtt 120ttgttgttgt tgttttcttg ttgttttgag agacagggtc tcactttgtc acctaggcta 180cagtgcagcg gcagaatcat ggctcactgc aggcttgacc tcccaggctc aagcaatcct 240cccaccacag cctcccaagg ttcagggatt accggcatgg agccaccatg cccagcctgr 300tgattgttta tattattcac aactgggcca cttcgtgtgc tatgactata acattttgtt 360tttcctagag ttagccattg cctctttttt tttgtcttct gtgttcttat caataactca 420ccccaggctc tctgctattc ttataaatct ctcaatacat tcaagaacac tgagtaattt 480atcagtttaa tttatttttt ggcttcaagt gctactgcat tgtcctaata ctccattgtc 540gtaatactcc ctcattcaga tggtagcagg gttttaaaac actaaagtag ttttaaatc 599592599DNAHomo sapiens 592gatatgatga cagctgtcaa gagggacaag gcatttcagg tgggaagttt tctagatcca 60aaatggggat cagaagtcac aactccaagc accagggctt gccctggggc tgacttctct 120tgaatcattt cctctgagat tcatgttttc ccataagaac cacttgaatc ccctcttatt 180agtctccctc tgtcgtgagc actggccgca cccctgttcc tgtgtgtaaa ttctcctgct 240tccccaaggg ctgtttcttg gctgaggttt atcaggcatc agagcatcta ctccacaagk 300tcacatgact ctggcatctt cccactcatg catttctttt ttaaaaaatt tttattttat 360tttattttat tttatttttg agattgagtc aggctctgtc acccaggctg gagtgcaaag 420gcatgatctc tgctcacttg caacctcaac ctctgcctct cgggttcaag tgattctcct 480gcctcagcct ccagtgtaac tgggattaca ggcacgcacc acccccggct aatttttgta 540tttttagtag aggtggggtt ttgccatgtt ggccaggctg gtcttgaact cctgacctc 599593599DNAHomo sapiens 593ttgagattga gtcaggctct gtcacccagg ctggagtgca aaggcatgat ctctgctcac 60ttgcaacctc aacctctgcc tctcgggttc aagtgattct cctgcctcag cctccagtgt 120aactgggatt acaggcacgc accacccccg gctaattttt gtatttttag tagaggtggg 180gttttgccat gttggccagg ctggtcttga actcctgacc tcaagtgatt cacccgtttt 240gtcctcccaa agtgctggga ttacaggcat gagccatcac gcctggcccc tactcatgcr 300tttccatcta gccatggcca ggctgcctgc agccagtgta aaataccaat ccatcttgat 360ctatacactt ttaatgagca actactatgt accaggcatt gggcattatt tcagtgtttc 420tcaaacttca gtcatttgaa ttctgcttcc caggttttcc aagtttcatc tgtactactt 480ttgacttaat atttttcttt aaattggctc cttttttgtt tcaataaatt tattttgaaa 540aggaacttta gagcactgcc atcagtgaaa aaaacagtag acagtaatat ttttcaaaa 599594599DNAHomo sapiens 594ctcagcctcc agtgtaactg ggattacagg cacgcaccac ccccggctaa tttttgtatt 60tttagtagag gtggggtttt gccatgttgg ccaggctggt cttgaactcc tgacctcaag 120tgattcaccc gttttgtcct cccaaagtgc tgggattaca ggcatgagcc atcacgcctg 180gcccctactc atgcgtttcc atctagccat ggccaggctg cctgcagcca gtgtaaaata 240ccaatccatc ttgatctata cacttttaat gagcaactac tatgtaccag gcattgggcr 300ttatttcagt gtttctcaaa cttcagtcat ttgaattctg cttcccaggt tttccaagtt 360tcatctgtac tacttttgac ttaatatttt tctttaaatt ggctcctttt ttgtttcaat 420aaatttattt tgaaaaggaa ctttagagca ctgccatcag tgaaaaaaac agtagacagt 480aatatttttc aaaagtagac agtaacctta aaataaatgc ataactatta aaataaaaac 540ttttgctctc tgtcccccta gtacccacca atgctgcata tacctggaat gatgctgct 599595599DNAHomo sapiens 595caccaatgct gcatatacct ggaatgatgc tgcttttcac cccattccca caaggtgggt 60ttcattgcca tctccattct acagatgtgg gaactaaggt tcagaggggt gaagggactt 120gtccaaggaa agaggtttgg aaagtggtgg gatcgaggtt caaatccagg tctgtctgga 180atgaacacca atgagcctca accacaaggc ttggggtctc tgaggcccag tcttggttcc 240caaggtgcat gcaagggtct tctgtcttcc cagtggtggt atgcattgat tccccaggay 300gatgaaaact tgctgtaccc ccttctccat ttatccacag ataaaagagg cagagattac 360cgtgaaagct tcctgatggt gtgagagagt cacagaggtt caatctcaca tcacatgacc 420cagctttgtt ctctgcccat tcactaacca ctatctgtac taatctctgg cgggagctga 480ttggaccaag ctaggctcct ggctccggct gggccaatcg gattctctcc tctactctct 540ctttctctgt cctctagctg ggcttgggtc aaggtgagga gacaatcagc ccaaagcgg 599596599DNAHomo sapiens 596gttgccatga cttgtttaac tttctacctc cttgttgctc tatgggatca gagactgtct 60gtcttattcc cttctgtagc cacagtgcct gtcacttggt aggtgcataa taaacatttg 120ttgaggtcct cctggcctcc ccacttacca gctatagaat ctttggcaag tcacttaaca 180tgtctcagcc ccatccattc cctcatttgt aacacatgga caataatatc tacctcacta 240gtttgtggaa ttgcagtgaa gattaaataa aaggatgatg gaggaaaagc ttagtaaatk 300ctgaaatgct caaccaaagt aaggacccta ctaagtcaga atttctaaaa ctgtcactgc 360actggtttac atgaatcaat ttcagatgat acccagaagc aatcttattg aactaattgc 420atgtttattt gaattaaaat agagaaaaaa tataagcagc cactcaaact cagatgtatt 480aattagggat gcatttggtt tcaaataaca gaaaactcaa caagtagtgg cttaaacaag 540taagggttaa atgttttcag ttaacaagat ttttggactt caacagtcca gggttggtg 599597599DNAHomo sapiens 597ctgggatttg agagtaagtt tttgccaagt acaatgctaa tcacttagcg ggtcctcatg 60gttatttttt tacctaaatg aagttcaggc tgcaaatgta cctgttatgg gttaaattgt 120atccccccaa aagctatgct gaagccctaa cccccagtgc ctcagaatgt gactgttggg 180agacagggtc tttctagagg taattaagtt aaaataaggt cacgaagatg ggtcctatcc 240aatacaacgg gtgtccttat aaagagggga aattcagaca caaagacaca cacaggaagr 300gggtcatgtg aagaagaaga tggagatcgg ggtgctgttt ctaccagcca aggaacacca 360tgcactgcca gcaacccaga agccagggaa gcggcctgga acagatttgc cttcacagcc 420cttgggggga accaacgctg ccaatacttt ggtcttagat ttctggcctc tagaactgtg 480agacaataca tttctgttgt ttaagccacc cagtgtgtgg tacttcgtta tggcagccct 540aacaaactaa tacatcactc ttcttccatc ttattttgtt attgttggat ttttttttg 599598599DNAHomo sapiens 598agtagggtta gccctgcctg aaccatgtgg acagagagta ggagaagggt gactaaatca 60ggtgcttttt ccaaaaggag agaagtggac accaggcaga gcacaccaag aagtgttgct 120gcagaaatgt agtaggggtt ttcccctctt tttccagtag aagagatgca tcatatcaag 180ccattctgat tttctgttct cagttttctc aaatgacaaa taagaggtgt tgtgagcttg 240gtgtgagaag ttccaaagaa ttttctggaa tgatggaaac attctttatc tgtgctgtcy 300ggtatagaag ccacaagcta tgacattgct actggactct taaaatgcag ctagtgggac 360tgagaaactg aatttttcat tttaattaat ttaaatttaa atagccacac aaggccggtg 420gctgctgtaa tcagacaaca cagaataaaa gcctgctaag tttttctgtt agcattggat 480agaaatgtga gatcttcaat gcatctggtc tgtagtaaaa gaaactctct tgcccttgtc 540tgctgccaga gaaactttct gaatctcagg gagtttttcc acgagagtga tgggaggtc 599599599DNAHomo sapiens 599gactggagca ggaggatcac ttgagcccag gagttcaaca gcagcctggg cagcatagca 60agaccccatc tctgaaaaaa aactagcagg gcataatggt actcatctgt agttgctgct 120attcaggagg ctgaggtggg aggatcactt gagcccgaga ggctcagtga gccatgattg 180caccactgca ttccagtctg ggtgacagag caagattctg tctcaaaaaa aaattttttt 240tttgaaagaa tcattagcac caaaatgtta atagtaatag cgcctgagga ggcagaactr 300tagtttgtgt gtgcgtgttt caaacatttt cttctttctg cttgtttggt tagttttcat 360gttgatttct ggtaatgaac attgctctta tgataaggga gcaccagcct cctcctccct 420tgtataaaat agtcaaatgg tgtgtttaca ttaaaacagt attatacctc caaaggggcc 480gggtgcagag gcacatgcct gtaatttcag cactttgaga ggccaaggtg ggcagatcac 540ttgaggtcag gagtttgaga ccaacctggg caacattgca aaaccctgta tctactaaa

599600599DNAHomo sapiens 600attgaacacc agagctttct gcccatcaat gcccttgcca tccctcccct ctgtttgggg 60tctgggttta ctcctgtgtt aaaaaagcaa aaggcccgac acacaaaggg aacccacata 120cccgtaaggc cacccagcct tcttcaaaca cccagccgct ttgctcttgg ctgggattct 180ctgggctttg ggagcctcct gctaatcaga aaccctggtc tgcagtttgt acgtctttga 240tgaataaaaa atggggaaac aaattaatta ttacttaata aattcagttt ggttgacaam 300aatttttcag aacatgaggc ctccaaagtt ggagtcagcc caggtgtcca tcaacgggtg 360gccagtgaaa tggacgatga cgccttctca tggtggcatg cctgggatgg ggagctccgg 420gcagtaacgt ggaaaggtgg gaaggtgtcc ggggcatcat gtctaaaggg aaaagaaaat 480tgcaggggag tttgagtttg gacagcacaa actcattctt gtggatggaa aataaatgta 540catgggcagg gatgtaaata tgatgtagtc acagagaaaa ttctaaaaaa acgccaaat 599601599DNAHomo sapiens 601gacaatcaat ttgaactcca aacccatgcg agtgcaggat tatggttata cattctcagg 60ggaagctacc ttttggtttt ccaaactaga ggcaaggcag agacagatca aggcatgtct 120tcttccagtg ttagtggata gaggtgttct gatccacata ctcgctgagt gtgaaggcct 180cttcagtact aagatgggca cctatctatc ccatgcccca ctcctttatt gcagagggca 240cttaattatt ggttcacata cttagcagtc tgagtgagtt ccctcttcag ttttggcccy 300tgggaatttc ttactttttc cagaactgac ctatatattt aaagggatgc tggtatacct 360tatccagtat ttctgggtgt tttatagtgg gagcatttca ggttatattg tcttccatgt 420tactggacac tgaagtcctc tcaatgtaat gaaaattagt ttctccttta gaattctttt 480tagaaggtct ggtagcctcc tgcttcactg gtgacctgac acttttcact taccctgggg 540tctgagccca ctttgtcact cacagggacc aaaggctgaa caaatcctgg gagtctctc 599602599DNAHomo sapiens 602tccaacagtt cttcagtctt cttttgtctt taatggcctt gacacttttg atgaaaactg 60gccatttatc ttgaagaatg tccctccatt tgagaatgca gggtgtttac ttatgattcg 120attcaggttg tgcattttgg gctacaggag tgatgttgtg tccttctcca tgcattggat 180caggaggcac cactgctgtt aactttggtc acttgctcaa ggtgaagact ggctggatcc 240tctgctgtaa aattattatt tttccctttg taactaataa gtgcttgtgt ggaaacatty 300tgagacaatg taatactctc tgtcatcatt cttttgccca ataattttag catgcatcga 360tgcttcttgc ttgaaacaat tattgctatg gtgtttgcca aatggtgatt ttctgtttcc 420gtcattactt ctacatttat taattgaaga gcttttttcc ttcttcccca tttatttatc 480tattcagttt tttatttata tcagtgtgga ctcagattca tattttaatc tgtttcccct 540ctctctctgc cacctccata cccactgtct ctacccacta tcttttctct ctcttcccc 599603599DNAHomo sapiens 603ggacgtgatg gcatgtgcct gtggccccca gctactccag aggctgagac agaaggattg 60atcgcttgag cccaggaagt cgaggctgca gtgagccgtg attgtgccac tgcactgtgg 120cctgggcgac agagcaagac cctgtctcta aaaagaacaa caaaaaacac tcacaggttc 180tgagggtcaa gatgtctttg aggagccatt attctgcctg ccacagagat gcccccatgg 240aaaactctca aactctgtgg cgccctaccc tctcacccag agctctaata atttcatcay 300ttatcacaca tttcaaacaa cccacgttaa ttgagcacct actatgtgaa gagccagagc 360aggacccagg gaaggaaggg aagactcggg aatgaaaaac aagattccct tggtgttcca 420tggctgtcag gttctctgag aaacgttttc caaacatttt aaagattttt tgtcatttct 480ctctctttca atttgtgttt gtaagagcag ccagtgacat ttagctgatg catcgaataa 540taccattgga caaagtaaac gggaggccct caggtttgcc aagctgcccg gcagagcat 599604599DNAHomo sapiens 604ctgcctcacc ctcccaaagt gctgggatta taagcataag ccactgctcc cagccttcac 60ctgctttttt cactcaatat tatgttatta ggattcacac aaagggcacg gtagctcata 120cctgtagtcc tagctactcg ggaggctgag gcaggagaac cacttgagcc caggagtttg 180agaccacaga gagctatgat cgcacctgag atcgagccac tgcactccag cctgggaagc 240atagcaagac cacatctctt tttttaaaaa aaaaaaaaga ttcatatctg attttgcatr 300aggacttcct ttttcactgc tgcatagtgt tccattgtgt gatcatccca ctattttttt 360ttctagagat ggatgtctca ttctgtcacc caggtcggag tgcaatcttg gttcactgca 420gcctcgaatt cccaggctca agcaatgctc ccaactcaga ccctgaggta caggtgtgag 480ccaccacgcc tggctaattt ttgtattttt tgcagagact gagttttgcc atgttgccca 540ggctggtctc gaactcctaa actcagacaa tttgactgcc tcagcctccc aaagtgctg 599605599DNAHomo sapiens 605cctgagtagc tgggactaca ggcacctgcc accatgccca gctgattttt gtatttttgt 60aattttgtac agaaggggtt ttgccatgtt ggtcaggctg gtctcaaact cctgacctca 120agtgatccgc ctgctttagc ctcccaaagt cctgggacta caggtgtgac gcactgtgcc 180tagccttggc ttcctattct gggagagcag gggaccccgc cacctctact cacatccctt 240cccaggccgt gcatggtccc acctcctagc cgctgcctgt gccattcctt ccacaaggar 300caccattctc catcttctct gcttacctct atcctacctg tggtcaaatc cttccatgac 360aataaaatct acaaccaaaa caatcagaca ttggggaaat gcaaataaaa actacagtga 420aataccactt acacacccac caggatggct agcgtcaaca aatgggagat aacccatgtt 480ggtaaggacc tggagaaaca gaaacccttt gaacttcctc agtaagttaa acacaagagt 540taccatatga tctagccaac tgtactccta gatatatgtt cgaagaactg aaaatgggg 599606599DNAHomo sapiens 606ccaagcaaga aattatagca aactgtgaca atatatattc aaggtgctat tagaccccaa 60aagtctaata gacctcaggg aagggacatt taggactgga tcttgaggaa tgcataggag 120ttcaagatta gaaggaaagt cctcaggatg gcaagaccag cctgagcaaa gacatagggg 180cttagagagg agcctagatg tttgtgaagg ggagtgaggg aaatgctgta gctccagttg 240gcagggacaa gggagttcag agccttaatc accaagacaa ggtgatagac atttcttgcr 300caaggggcaa tggggagcca ttgatgattc tggagcatag gagtggtctg atccgagtga 360ccaactcacc cacgacagag aaggaaggaa cccatcctgg gctcaggatg tctcttctga 420aagtaaagcc gttgctccct tttcttccag ctgtcataca ttttaatggt tattttaaca 480agtttccagc aggtggcagt tgaatgcctc aaggaagagg catctttttc taatgtgctg 540ggattaggtg tggccagtgc tgggattcct agaccccaca ccatgcttgc caacccatt 599607599DNAHomo sapiens 607cactgagctt cccacaccct gtccccttcc ccaaggcctc ttatccactt ccaccatgct 60gtcagcaaac tcagatccca tactttgtgt gtgcctcaca tttcacaggt ctgccctggc 120tcaatgcgtt gttggtcaca gtcggagaga aggtccctga gcctttgacc cacggcatgg 180ggaaatgaat gcctggtcag gtcagggact cttggttgtg tgatcctggg gaagctcctc 240cctgctctgg gcttcactct tttcagggag acagggcttg tggaccttgg agagtagatr 300tgtggtgccc ccagaaagac acacacacac acacacacac acacacacac tcactcttcc 360atggaaggca tattgcccat tagaatagat gtgtggtgcc cccagaaaga cacacacaca 420cacacataca cacacacaca cacaaacaca ctcttccatg gaaggcatat tgcccattcc 480ctctgcctgg gcaatcagaa cggtctgtgc ccctggctat gatgaggggt tcaaggatag 540acatgtgacc catgcctggc cagccaggct cagacctgag accctgttaa gtgggagga 599608599DNAHomo sapiens 608ggagtgcagt ggcacaatca tggcacactg cagcctcaac ctcctggact caagcaatcc 60tcccacctcc gcttcctgag tagctgggac tacaggtgca tgccaccact ccaggcaatt 120tttttgtttg tattttttgt agagacaggg tctcactatg ttgcccaggc tggtctcgaa 180ctgaactact gacctcaagt gatccaccca ccttggcctc tcaaagtgct ggaattacag 240gtgtgagcca ctgcaactgg ccagatatgc cacctttggt ttatccatcc atccatccay 300tgaggaccgc agggtgtctc cgtttgggct actgtgaaca cccaggcatc tttgtggctg 360ggaacaggag aggtgtggag agcagacagt gagtcagaag aactaaaaag ggaaatttgg 420gaactagaac tgggctttgg ccaccgagat caagtcctga ttttacctcc aaaccgtgtc 480ttgaatccat cacttctcca tctctgccac cacttcccca tcccaggcca ccactatctc 540tccccaggtc ggttactgca gcctcccttc cggcctccct tctgccactc ccaactccc 599609599DNAHomo sapiens 609tgggcttttc tcaggaggtt gggaagatgt ggcaggaccc acaaaggaaa tgagaagata 60cagccagtga cataggagaa aaaccaggag aagccaattg caggtcacgt atctgggctt 120gataactatg gatgtaccct tggcgggctt ctccccacat tggaaggcag gtccaggaag 180gcagggggtt tggtctgcct tgttcaccgc tgtgtctcag cacctggcag tgcccaggac 240atagcaggtg cttggtgacg aggatatgag tcagtggctg acctggtgtc ccctggcccy 300gctgtttggc atccagatct cagtctctgg actgatggca gtgatgcccc tcttcaccta 360gccaccagca ggggcagatg gtggtccagg tgggatctga ggcggagctt ccttccacca 420tggccacccc acccaagaag tgggctgagc cagccaccca caagagggaa ccgaaatcat 480cctccaccac aaacacgctg gcctggctcc acactgggca ggacatggag gaagggggag 540cgatagtgag ggccagagtc cctccacttc aagggtcccc ttcccctggt atatacatg 599610599DNAHomo sapiens 610taatcccagc tacttgggag gctgaggcag gagaatggct tgaacccagg aggcagagtt 60tgcagcaagc tgagattgtg ccactgtact ccagcctggg cgacagagca agtctccagc 120tcagaaacat aaaataaaat aaaaataata gctaatgttt accgagcact tgagggtttt 180gcttcttacc atgacactga taattaggaa agactttact atctctattt taaacataaa 240gaaaccaaac agagaggtga cgcggcttgc ctgaagtcac acagcgagca agtaaacccs 300agcttagaat ctgagtagct gtgcaacctt gggcaagtca cttcacctct gtgagcctca 360gtttcctcat ctggaaaatg gagatgataa gggttgttag aagaattcag tgagcttcat 420ggcccatgaa cttgtcactc tgtatttaag ggtatttaac ttgtcacttt gtatttaagg 480attcactttc caactgcctg tctaccatga gaacaaacac catgtctgct gtgttcccca 540ctgtatcccc agtgcctgga gaagtcctag cacatagtag gggctcaaca aatctcaag 599611599DNAHomo sapiens 611aaccttgggc aagtcacttc acctctgtga gcctcagttt cctcatctgg aaaatggaga 60tgataagggt tgttagaaga attcagtgag cttcatggcc catgaacttg tcactctgta 120tttaagggta tttaacttgt cactttgtat ttaaggattc actttccaac tgcctgtcta 180ccatgagaac aaacaccatg tctgctgtgt tccccactgt atccccagtg cctggagaag 240tcctagcaca tagtaggggc tcaacaaatc tcaagttgag gggcagtgta ttctcttgam 300cttatggggc cctaactcct ctcagccttc ctctgctgcc tggtgctgca aacgtccaac 360cccagggcca ttccagtcaa cccaatagat gcaaacagga ccatcccagt ctcctgtttc 420aggtatgagg agcccacaaa gcacatttgg gtgttatgat tgctaggagg acccagtgct 480gttctctggc cattgccaag tggctaaaag ctgcacacaa acaggcttca gccaaaaaga 540aatgactgac ttacagagct gagaagtcca agagtgactg ctttcaggta tggctggat 599612599DNAHomo sapiens 612catcatttat ctcagtctag atccagaaca tttcatcacc cctaaaggaa accccatact 60cattagaagt tacttcctat tcccgctgcc catagcccat ggcaaccact ggtctacttt 120ctgtctctag gggtttacct attctatata ctttacataa gcagaatcac acaatatttg 180tccgtttatg actggcttat ttcacttagc atgatgcttc caagtttcat ccacattgta 240gcatatatca atgcttcggt cctttttatg gctgtgtaat attccattgt atagatagcr 300ttgtcttgat tcattcatcc cctggtgggc acatgagttg tttctatctt ttgcctattg 360tgaatggcac tgctatgaac attcatgtac aagtatctgt ctgagtgcct gttttcaatt 420cttttgcctc tgtactttag ctaacatttt tgtttgttta gagatggggg tctcactatg 480ttgcccagct tggcctccga ctcctgagct caagtgatcc tcccacttca gcctcccaaa 540gtgcagggat tacaggcatg agccatctca cctggcttta gctaacattt tgatgcttt 599613599DNAHomo sapiens 613ccagcctggg cagcatagtg agaccctgtc tctaccaaaa aaaaaaaaaa aaaactgggt 60atggtggcac atggctgtgg tcccagatac ttggaaggac tgcttaaacc cacaaggtca 120tggttgcagt gagctgtgat catgccacta cactccagcc tgggtgacag tcagacctgt 180ctcaaagaaa gaaaaaaaaa aaaaaatcct ccccaagcct cagcagggga attcctacca 240tggataaagg ctttctctgc atgtgggcct gatcattaaa aggaaaattt cagcctcccr 300aattatacta ttatccaggg tgattagata gaggagaggc tgagaagccc tgatctcagc 360ggggcatgga ttaaggggac cccacagctc agccaggttc ccagcgattc aaggtcctgc 420gatttctcac cgacttggtg gctccagggt gcctggggct ggctgtgctt cttggggagc 480accaggtacc actgctgctt cgaggccctc aatagccctt tggtggaccc ggttgtgttc 540tgagcttggg gtcctgagat gcagacaccc cccagcccca gctggtgggc gtgcagcta 599614599DNAHomo sapiens 614ccaagactcc tgttctctgg gagccctgat ggtagggccc catcagattc cctagggctt 60ttcccaatcc agggaaccag ggaggtccca gagggctttg ccgtagccct ggctggctgg 120ggctctgtca caggcttggt ggttgctgcg gggcctgggg tgttgcctgc aaagcaagca 180gccctgggga ggcttctcct agcccctcgg agcatcaggt ggaacagtcc gggcggctca 240ggagcatccc ctcagtgaat ctgtgtccag gtgatgggcc aagggtgctc agaccacaay 300tcttgcatgt gcttgccagg tagtcaactg tgatccctga cctctgaccc aggggttggc 360tctgggaaca gttttaaaca aaaggaaaag aaagttctga caaccagtgg gtggtggcga 420agggcttaag ctttggatct gcacttgcgg tctgtcactt aaagggtgcc ctgcaggaga 480gggagcagat gtaatcccag tgccagcctg gtggaggccc tgctgcccag ggctggaaga 540ggctttggag ggagagagcc aagagaaggc agctgcccag aagtctgagg ccaggtggg 599615599DNAHomo sapiens 615gaaggaggtg agagagactt tgcttctgag ggccccttct gagcccttct agtcttcttt 60agttcaagta cgtagcatgc cacagcacct ttctttgggg tgttgttttc tgagccccaa 120cattcatggc cctgaatgtg tgcctctgtg tgccaggtgt tgccctaaat tcttggacct 180tcccatgagc tggagttcac tgacccattt gacagatgag gaaactgagg cactgggaga 240agcaaagaga cttgcctggg atcatgaagt gaaggggatc tgaaccctga gacaggaacy 300cttgatccca aggggcccct aaccccaagc ccttggcccc ctgctgaact ggttcaaacc 360agagagtgta taacccagct ccaggctggg ctgggcctga ggtgtgcgtc tcacctggca 420gttacaagaa aaggaaattg cactggttgc cacatttaca acctaaagtg gagagatttc 480acagaatcca gacttctggt ttctcttatg gaatccgggg atcggccggg cacggtggct 540catacctgta atcccaggac tttgggaggc gaaggcagat ggatcacttg aagtcagga 599616599DNAHomo sapiens 616acagtgccat caataatact gacagtaagt ccttctaagg actcactgct cacaggggca 60gccaactgcc caggttccaa gcccctctca gccacagggg ctgtgagacc ttgggaaagc 120cacctaagct ctctcagacc tagtctcccc atctgtgaaa tgggcctaat ggcgcagcta 180ccctcacagg gctgctgtga agataaaatg aagccaggtc agtaaagtgc ctgctgtata 240aggaaagccc aataaatggt ggtttaaagg gcatttatca acagctagaa ctccatcatr 300tcctccactg tacagatgag ggaaactgag gctcaacctc cagaaccacc agggctggca 360ggacttcaag accatctcag ctaatccatg cctgggcata tgtggaaact gaggcccggc 420aggctgggca tgctccattt gaaatgggag ccccacctcc ccgggaaggt ctggggccca 480aggccagcta ctccagccta gcagctgctt ctggaatctt tctccttccc cagggccccc 540actgctgtcg cctccccgtc aggctctact gctgaaccag tggcagcaca ggccaggct 599617599DNAHomo sapiens 617catttctgtg acttcctctt ggaaaacttt ttgaaaaatg ttgccggcct gtgaattcca 60caatctggaa actgctggtg ggccacccag gctccaatgc ctggcacaca gcagatgctc 120actaaagggt ggtgtggggt ctgtgagcgt catttccagc cacagtcaag cccctgttgt 180cttctagcct ggggctgtgc cttctgccct ctgggtgttg gctcttgcta ttcccttaac 240ctccagtgcc tttttctcca ccatccccac ttcggagaat attcagcaaa cgctactgcy 300cctttctctg tgctgggcca agaccgaaag atggaaaagg aagagggagg ccttcttgag 360cctctggtgc atgggagcag gggagtgaca actcaggagg gctgcccagg gaggggcctt 420cttgctccca agtctctctt aaggctgagc tcctaaggcc ctgtgctcct ccctgcctta 480ccattcccct gagatccttc cataccctct gggagctctg ttgcacacac tatgctcata 540ttctcaggga agggtagtgg cattattatc ccaccttaga aaatgcagac tcttgcttg 599618599DNAHomo sapiens 618tcattttttc acaaggtgag ctaacacaag cgaaaggcat gactcgcaca gctgttaaca 60ggccggtgag taaagcctgc ttggctccca ctacactact gacagcatga cagtcccctc 120tgagtagcct agccactggg tacaccccca gcttctctca gccttacaga actattgccc 180cattttgtca catgctccct taccatcctg caataaattc cacgtaatat aaccaacata 240ctaccctaac taattacaag acagggacaa caaaggactg tcacttagcc gaaataaaam 300gtgcttcagt gcaactgtag acaacacaac caactacttg gctgcttctg agtttgttgt 360gaaaagaagg ctaagaacat aagggagcca aagggcgggg gagctaggaa agccagcctg 420gttccagatc cacccagggt ccacatggaa atgcagttcc aggctccctt caaatggccc 480tgtgctgtga tcagtccccc tgcaaaggtc tctgagccac agtcccgtca tctgagaagt 540gaagatgaaa caccagcctc gtggggtcac gcagctctcc ctgactcccg cctacctga 599619599DNAHomo sapiens 619tgagcacaac ccaggggttc ttccccaact ccccacagca gcccttgaga gccgcccagg 60cctagagcca caatctcaac ccaagcctgc caagtatcag agccggggtc cgccacagct 120acctggtggt atgggtgtcc tatgccagag gctccagcca ggttgcagcg tgtgggcaca 180tgggcgcagg acaacccctg cttcagtcga aacctcagcc tggacagctc aggctctggc 240cactgcaggg aaggaccacc agatgcccat cagattaagc tatatggggg gatgggtgak 300aggggagaca agctcaaacc tgggggctgt gtcagcagct gtgggggctt taggttccct 360cctctcacat gcccgctatt ccacctccct caaaagtcaa gccaggccag caacagctgc 420tccctggacc tgcttaggct ctactgtggt tgggtgatca aagtggccag atcatttcag 480gtatttgtgg tttgaacagt agactgtcac ccaccacatc ctgcagcgtc tatttctggg 540gagcaagtct tctccattcc cagcatctaa acagatggct tctgtttgtt atggccact 599620599DNAHomo sapiens 620ccaggtccaa tgggctggga gggctggcct tctgccagca catgcttctt gggatctcag 60tgtgaatggt gttcaggagg ctaggggaag gcaccctgga cctcactaca ggctcagagc 120ctgcccagca acaccatgga tactctctct aaaaggggga ctcctgggga gactatagac 180aaactcaggc ctggctggaa gaaagagcat caggaacaag ccttgagtac cccaacttgg 240tctcgtagag ttcaaggccc aagctacaag cagcttgctc cagcatccag gaggtccggy 300ggtgcacacg gcttgagatg cctgacaacc tttacacctt tgtgctgaag gtgagtgaca 360aggcttttca caccctgggg caatacaaat acatacacat acagcagacc caaccctgtt 420cccttcctcc ctgccaggtg aaggaccgga cagacatcat ctttgaggtg ggagacgagc 480agcagctgaa ttcatggatg gctgagctct cggagtgcac aggccgaggg tgaggtcctg 540ggccctcgtc cctggcacca cctttgctgc taccacccct gacctgccca gatccttaa 599621599DNAHomo sapiens 621aatctctatc tatacaagtg atacaattca tagggggctg gctcctccca gaacctgtct 60ggaggctcag aaacgggggc agtgacagtg gagtcagctg ctcttgggtg ccagcagagc 120cattcagtac aacccccagg ctcacagcag tggcttctag gaaactggga gtttagatca 180gctttacaga tacatcgatc agaggctaaa atgaaacctc agcctaaaac tcataggact 240gactgcctgg gaggagggtt aggtctgctt cttccactta tacttagtct ctgtgctccr 300agaggtcaaa tttttgcttc tagaatttcc ttggggtctt tcagagggtg ggggaacaaa 360cccctatgca cttttctttt tttttttttt gagatggagt ttctcttgtc aaccgggctg 420gagtgcagtg gtgcaatctt ggctcactgc aacctccacc ttcctggttc aagcgattct 480gcctcgacct ctcaagtagc tgggattaca agcaccagcc accatgcctg gctaattttg 540tatttttagt agagacaggg tttcaccatg ttggccaggc tggtctcgaa tgtctgacc 599622599DNAHomo sapiens 622cttaaagaaa aatgggacca cctgggtgct tccagcttct agttacactg caccaatgtc 60caaggccaag ccctctcaag agtacaactt atggtcaaag cagatatatg gataaccagg 120gaaaacaatt ggagagatgt gtctggaact catgtgagta acaatcaagt tgacaggccc 180cggtagtcac ttcggagagc tgagactctg tgaaggccat catccctgcc tggcttccaa 240ggtaagtgtg taggggaata tatatgtaca catatatata gtagtgaggc tatatagacr 300tagcaaagca gacacagaaa ggaaagaagg actgggttgc attccagagt caaagatatt 360tttaaggtct cagttggaaa actaaaggac tgaccaatca gcaccttcac tgatcccatg 420acaaaaccac acaaacattc ccttagggcc agatcacgtg tatttgagag ggaaagggag 480acaggcaaat ggcatgacac acagggtttc ctagctggga gagcctctag ctgcttactg 540ataaccttca cattctactt ggccttcaca gaaagttggc taaagctggt attacctga 599623599DNAHomo sapiens 623ttgctaatgg aggcagttaa agatgtcttt gatatctatc agttccctgg ggcagtagtc 60ttttttgact ttagtatgta tgctcagaag tttctaactg ccagactgag aatcaggctt 120ctgtacccta gaaaggagtt gtccagatgg gaggcacctc cagccttgct cttaccaccc 180tgtacattct cctgtacttt ccagtgaccc tcatcatagg cccaagtgtg caaagcttag 240ctttgtgggt atcccttggc tgcttttcat taaagaagtt ttcctctcaa ttctttcctr 300tcgctttgca gcaccatcag caccaggccg cccaggctct ccatctggcc agtccacagc 360agcagtcagc catttaccac gcggggcttg cgccaactcc accctccatg acacctgcct 420ccaacacgca gtcgccacag aatagtttcc cagcagcaca acagactgtc tttacgatcc 480atccttctca cgttcagccg gcgtatacca acccacccca catggcccac gtacctcagg 540taataccagc

tttagccaac tttctgtgaa ggccaagtag aatgtgaagg ttatcagta 599624599DNAHomo sapiens 624gtgtgcacct aaaatgcact tgtttgagta gtttctgcct atgccttcaa gttgcctttt 60tgggaaaacc tagtgaccgt taagagtaaa tgcaaactaa tttgatttta atatcatatg 120tagagctgta ttatatgaac caaatgctag tctgttaagc aatagctaca cttatttttt 180caagacaatg gatggtttaa atggagtcat ctatagaaat tggtagtggc gtgagttatg 240cattgtaacc atcaagaaag ttcagttgat gaagtgtaga ggagcgatgg aggttgtcas 300acatcggttg tgtacatgct cctttttctt tcactttagt ttccacgggc tcccttgctc 360agcagtatgc gcaccctaac gctaccctgc acccacatac tccacaccct cagccttcag 420ctacccccac tggacagcag caaagccaac atggtggaag tcatcctgca cccagtcctg 480ttcaggtaag ggcaactcag aggtctgcat ggagtggctt ctttatccta gtatctgagt 540gctttcttca ggtgccaggt atcgcatcgt cagaacacat ggcatgtcca ccctcgtga 599625599DNAHomo sapiens 625tgccctcagg acattgctcc agggcagtag catggtgagg ttagcctgat gatggccttg 60agctaaagag tgtgcaccta aaatgcactt gtttgagtag tttctgccta tgccttcaag 120ttgccttttt gggaaaacct agtgaccgtt aagagtaaat gcaaactaat ttgattttaa 180tatcatatgt agagctgtat tatatgaacc aaatgctagt ctgttaagca atagctacac 240ttattttttc aagacaatgg atggtttaaa tggagtcatc tatagaaatt ggtagtggcr 300tgagttatgc attgtaacca tcaagaaagt tcagttgatg aagtgtagag gagcgatgga 360ggttgtcaga catcggttgt gtacatgctc ctttttcttt cactttagtt tccacgggct 420cccttgctca gcagtatgcg caccctaacg ctaccctgca cccacatact ccacaccctc 480agccttcagc tacccccact ggacagcagc aaagccaaca tggtggaagt catcctgcac 540ccagtcctgt tcaggtaagg gcaactcaga ggtctgcatg gagtggcttc tttatccta 599626599DNAHomo sapiens 626gcaggcggat cacgaggtca ggagatcaag accatcctgg ctaacacagt gaaaccccat 60ctctactaaa caaaatacaa aaaattagcc gggcatggtg gcgggcgcct gtagtcctag 120ctactcggga ggctgaggta ggagaatggc gtgaacgcag gaggcggagc gtgcagtgag 180ctgagatcac gccactgcac tccagcctgg gcgacaggga gagactccat ctcaaaaaaa 240gagacatcaa agagataagg tttttgacaa aagccctttc taagatagct agaaagaggw 300caaggtcaat acttttttag aataaaataa ttatcctatt ttatcattta actgttcagt 360aatgttagca tatgtgtatt aaacatacta aaaatttaaa aacaataatc aggatttcat 420tttgcagtca ttagtggtcc tatgttttca atgcctttgg ctatggctat aacaattaat 480gaatgagaaa aggtgacata aaattgtcac caacatctgg gtgcatgttc ttctgtttgc 540attaaatgtt ttaaaaacct agatatgatg tagcttaaaa agaaaagcac aattcatac 599627599DNAHomo sapiens 627tattagccag ctgcggtgct gtgcatctat ggtcccagct actcaggagg ctgaggtggg 60aggaactttt cagccaggga ggcagatgcc gcggtaagcc gtaactgcac cactgcactc 120cagcctcggc gaagaagtga gaccctgtct caaaaaaggg gagggtaggg gacaggaggg 180gaagaaaaga aaccaagccc ttgactctgc ctgttatttg aaaaatgcta aaaatatttt 240tatccaatac ctcaaaggat tggaatttag taaaggagca gggtaaaaac taacatatar 300acagcaatag ccttcatata tggtacttca taagtaatta cttagaagat gcaatggaag 360agaagtccct gggttacact aacattaaaa aagaacctac ctaaggcata cactgaaaaa 420aatgtacaaa accttaaaga taaactttat ttttatttat ttattttctt tgagacagag 480tgtcgctcgg ttgcccaagc tggagtgcag tggtgcaatc ttgactcact gcactctctg 540cctcctgggt tcaagcgatt ctcctacctc agcctccaga gtagctggga ctacaggtg 599628599DNAHomo sapiens 628gtggcgcgca cctttagtcc cagctacttg ggaggttgag gtgggaggac cacctaagcc 60caattggtag agactgcact gagctgaaat catgccactg cactccagct tgggtgacag 120agttagacac tgtctcaaaa aacaaacaaa caaaaaaacc tatgacttgg ctgggtgtga 180tggctcatcc agcacctcct aaagtgctgg cctgtaatcc tagcacttta ggaggctgag 240gtagaaagat aacttaagcc ctggaattta ggactagcct gggcaagata gaaagatggy 300gagactctgt ctcaaaaaaa aacaaaaaac aaacaaaaaa acaaagaaga agaaagacaa 360gacaagaaaa gaaaagctgg caaggtggca tgtgcctgta gtcacagtta cttgagaggc 420tgaggaggga ggatcctttg agaccaggaa ttcgcagcag cagtgagcta tgattgcact 480actgcactcc aagcctgggc aacaaagcca gaccccatct caaaaacaaa aaacaaaacc 540aaaaccaact taaagataca cactaaaatg ttggtggata aactgatgca atgtctaga 599629599DNAHomo sapiens 629gtgatccgcc tgccttggcc tcccaaagtg ctgggattac aggcgtgagc caccgtgccc 60ggcccccatt ggtgctattg ttttatgtga tagagccagc ttctcccttt tctttggatt 120tttaaacata ctcttccttt tacttagact attctccatc ccaacacctt tcctaaactt 180ctttcacacc ttagactagc tgacacttta ctgagaaacc tttctttttt ataggttgct 240ttttctatag actctcttag catttactca ttttattgtg aagtgtctga tcttatttar 300atgacaagta taagaggata gaaactattt catatttttc tcacccagca ggcacaattt 360ctgacatgtg gtaagcactc agtaaatatt gaactttaga ggctaggaca tttgagtgct 420ttggtgactg tggttgtgct atataggtac tctgttattg ttagtttata gtaaaagcat 480tactcttaaa gtatgaaaaa agccttattc agaacatttc atgcgtatag ttaatattac 540gtagcttgtg ctcatggcaa aaatgtatta ctaaagttat ttaagatatt taagtataa 599630599DNAHomo sapiens 630aggtccattt acctctaaaa cccacattat taacccaaaa cagatcaaat tactagcaat 60tcttacacaa ataaagctat cagcactctg catatggctc aaaagggaag gaacaacaaa 120cacacaaggt atttctattt ctgcctaaat gaaggactac agatatttgt gaacaaatgc 180agtttggggc tatgagcatg tcatgaagtt agctctaatg aatcactgac tgacagtgca 240gcatgcacta tgcattagtt actattcaaa gcactgctag aagcttaaac accagatggy 300cagccctctt acttactagc catgtgagtt tgggcagatt acttaacttc tctttgccca 360agctgcctaa tatacacagt gcagatacaa acagaacttg cttgacagag atgttagaca 420agatttaaca tacaagcatg aagaacagca tctggtacac aggaaatacg caataaaaca 480taagagaata acattatatt atctgaagag aacaattaga aagttcactc ttttattttt 540ttttaattaa aatttaagtt ctgggacaca tatttttttt ttccactctc ttttttttt 599631599DNAHomo sapiens 631acagtagact gatttagaaa gagtagtcac tagtggcatg gcagaatcaa taatgtagaa 60ttttgacaat tcatatagtg ctgatttctc ccccaaatgt cagttatttt ggtcatctat 120taatagacta atacaagtca tccctttaat agaattttca gctcacagcc tgctaagcct 180aagaaactgc ttacaggtta ctgcttactg ttttaagccg agttttaaaa ttgatgatca 240tgatagaaga gataaataaa ctaaaatttt agagaaattt aagaagggta tgtacatatr 300ttttagtggt atcggggtgt atagggatta atagtcttct gtttaaattt tttttttcta 360attttagaag taatgtagaa aattcgggtc agggaaaggt aaaatatatg gaaagttaaa 420aatattttat catgtagtca taatttctag taacatattt ctttacaaat aagacatagt 480tgaaacagat tgctacagtt cttttaagag ttgacatctt attgttgatt tcttaccacc 540aacttcatcc ctccctttct ttaaaaataa agggaaataa taaaatttat ttataaaac 599632599DNAHomo sapiens 632tacccagcta cttgggaggc tgaggcagga gaatcacttg aacctgggag gcagaggttg 60cagtgagttg agatcgtacc actgcactcc agcctgggcg acagagacag actctgtctt 120ataaaaataa aaataaaata ataattctat tggcaacata tattaatttg aagttctaaa 180gagtttggca gccgggtgag agagtgagga gatttggctt tgacattagg gaagttttcg 240cttggtgtta acaccagtag gcttctctga tgagggccat tctgtccact cttttacctr 300atagattggt ctaatgcaca gtagactgat ttagaaagag tagtcactag tggcatggca 360gaatcaataa tgtagaattt tgacaattca tatagtgctg atttctcccc caaatgtcag 420ttattttggt catctattaa tagactaata caagtcatcc ctttaataga attttcagct 480cacagcctgc taagcctaag aaactgctta caggttactg cttactgttt taagccgagt 540tttaaaattg atgatcatga tagaagagat aaataaacta aaattttaga gaaatttaa 599633599DNAHomo sapiens 633cagcaggttt gttgtataac tagagacttt ctcccaagca atatataaag aaaaatgttt 60gtcattttac ttgtaggggt taagcaggag tactgtctgt tcttgtggat gctcatgaat 120tacttctttg tgattaaaat aaataataag aagtagctta aattaaaatt agaaaccatg 180ggaaatgccg gtgtgttttg ctttaacacc cagccaaata aggtagccta aggaaagtgg 240tgtcttaatt gttgacttca cctagagaag aggttgaagt aggacatttt aagcctcttr 300tctgaagaaa aggttgtcat taagataaat aattaggtta cattggaatt aaagcattac 360ataaatttct tggtcttaaa tttggattat tctccacaaa attcttttat ttctaaaacg 420cctcttgtca catactagtt ttgtttctct ctttaatgca ttatctgtac ttgaagtgct 480tagctgggta tgctggcaca tgcctgcagt cccagctact tgggaggctg aagcaggagg 540atcacttgag cccaggagtt ggagtccagc ctgaatgaca taaggagacc ccttctcta 599634599DNAHomo sapiens 634aaatgcttta tttacttaaa tgtgtgcttt tcaaaaacta gtatgattaa gacattaaca 60ggatcttaga cgtaaaggaa cagtcctgtt gcttcttcca gaagataata tgactcgttt 120ggaattttcc tatagtgtag ttttttgtct agtgttgtga gaattaaagg gatttcagga 180tcttaaggta ggttattatt tgatgttttc ttggaacatt ttacattctt gaaaatacac 240atggctaaat taatttttgc cagcaatcca cataacttta agataatgta gagaagaack 300tgattcaggt tagtatcaaa taaggtcaga tttctagtgc catcagtagc tttcagcaaa 360gatgaggtgt tggtaagata gcattagtct cttagaatct cttagagaga ttttccaaaa 420ttcagccatt tctagtgaat gctccattcc acccccagct gagtcctgct gctctgggga 480actccctcag cacactcttg gctcttagaa ttgctagcaa tgggagtagt gctgctggtg 540gagctggcag ctaagcccag aggtggatta atgcttttat tccctgatgt acaggtaca 599635599DNAHomo sapiens 635tttttgataa ctgcatttca ttgttacttg ttctcatttg atttcctgtg tattttacga 60atttaagtac attctgaata cggtttcata ggcttcccta aaatattgaa ggggcccatg 120gattaagaaa aaggctaaga atccctaatc tagaggctcc ccacagtcct cttttgtcat 180cataccccta ccccattcta gcctgaggag cgtggctcca cctgtgccct tggttttgtt 240gttccagtcc atacatcctg cacccttaac tgtgtttctt atccccaact tgtttctttr 300tgttattctt cagtattata gtctttaata taatctgtat aatacatggt gtagtagtat 360atgctcgtag tatacaattc agttagaaca gatgagtatt caatgaaaag ataatctcct 420ctctaacccc cagtcccact tccctgggga agcctgtgtt cttgtgtaca attcagaaaa 480tgtttataca catatttttt atttatttat tttttgagac ggagtctcgc tctcgccagg 540ttggagtgca gtggcgcaat cttggctcac tacaacctcc gcctccctag tagttcaag 599636599DNAHomo sapiens 636gcgtgtggac ataggttttc aattctcatg ggggtgtgtg tgtatgcata ctcatacata 60catacacata cctgcaagat aattgctggc tcgtatgcta aatctatgtt gaacctttta 120cataactgtt gggctgtttt gttttctttt tattattttt tgaaaataga gttggggtct 180cactgttgca caggctgatt tcctgggcat agtggctgta tcattttaca atcctacata 240gctgtttcca acgtagctgt atcattttac aatcctacta gcagtgtctg aggtttcttm 300tgtttttcac atcctcacca gcatttgtta ttgtctgtct ctttgattat acccatccta 360gtgggagagt aagaagtagt atctcactgt agattttttt tttctgttta caactttact 420ttaaaaatta tatatgcaca catggtaaaa agttcaaaac gtgtgtacca aaagatttaa 480cagtgaaaat agaaaataag tgtggtcctt gttttcttcc accaaggcaa atattgttat 540aatctcctaa acaacttgtc ttccagattt ctcattttca gtcaatcttg ggcattgac 599637599DNAHomo sapiens 637cccaagcaat cctctttgcc tcagcctccc aaagtgctcg gattacaggc ttaagctatc 60acaccaggcc taggctaatt tcatattttg agatggcaca aatttctttc aggtagctag 120cttttcctcc tcctccccac ttaaaataga tcctgatcca gaagcctaat ggagaaaatg 180aaaacagaat gttcacccat aaacagtatc tttgtattgg aatcttttct aaaacttctt 240ttgatctttt taggagatag tgtgggaatc agcaatctag tattacgtac gtggaatctr 300tcaccttgtt tttttaaata cagcaaacct catgaagtga atttccatat tttttcttgt 360tcttgttagt tttgcaccac tcaggctttg ctgtagaatt tgatgtatat ttgattctgt 420agagcatggg ctattgatct tcactcagct ttcagaggaa tctgattagt aagtttgagt 480tttttattat tttttagttg attttgaagt aaaatacagc accattttaa ctgataccat 540ttctaaacaa ttttcagttc aaattttaag ttagctaatt tagagcttaa gaaaattgc 599638599DNAHomo sapiens 638attttcacta ttcaaatcta taccaaaagc tgtttttatt gttgggctga ttcttctaca 60ctgttacttg gaaataataa tataccagga ttctttctct tagacttagg agtctttctc 120tttgcttgct ttttcagagg ctaacagtac tgggtattct ttaactgtct tgatatgctg 180atgaaagcac agtgttctgt ttttgaatct tctcaaatgt ccttgtcttt gattcacaac 240tttttgtctt aagaggcctt cagcatccca tacaaggaaa caagtctttt tttagctgcy 300acctttggag ttgattttgt ttatgtctag gagcactaaa ttatttatac ttatactatt 360gaaatattcc tctgttataa attcaaaaat tgactttgga agataaaatt ttagttgaat 420ttaatacata gcactctgga aagagtattg gccacaacaa aaaaaaaggt tccctactct 480attggatacc aggtcattta acagccattt acggtatgca ttgtcttttt gtttttatga 540tgaattgata tttcccaaat gtggaagagt gaatattact ttgagatgtt tgtgatagt 599639599DNAHomo sapiens 639gcattttcta cagttttgtg gtcaagaatg ctactgatta tattcaactg aaaatttctt 60gtcccatttg gcctacaatg ctttagttta taagtgggca tgtggcaaat ctggaaagaa 120atcaaagtat aaggctaagg aagaaaggta gagaacggtt ggtagaaaac aattgtctaa 180tgaaaatgaa aaagggtgaa gaagtagaac atacgtattt taaaaatatt cagagtatga 240gacaaggttt tgagaattta aaagcgatta tgtagttata ttaaaaattt agtctcttty 300taagtgtcca ttgatgaaca aagtgggaat tcctgttact catttgcaag gcattattga 360gtgttcagta acacgttgca aggcacttct gggcaatcct gaacttggtt ctcaaattct 420tttttttttt ttttttgaga cggagtcttg ttctgtcccc tgggtggagt gcagtggcac 480gatctcggct cactgcagcc tctgcctccc aggttcaagc gattctcctg cctcagcctc 540ctgagtagct gggactacag gcgtgtgcca ccacaccaag ctaatttttg tattttttg 599640599DNAHomo sapiens 640tatttagaga cagagtcttg ctttgtcgcc caggctagac tgcagtggaa tgatcgtagc 60ctactgcagc ctcagactcc tggactctgg tgatcctgcc tcagcctcct gagtagctag 120gactagaggt gcatgccaca tgcctggcta taattattat taatttacgt ttagcattag 180tttttttctt ccagtaggct attttacttt atttatttga ttttgatgaa gtttgattat 240ttctagtttg cttccttcta tgacccctac ctgttgtggg tctccaggca agcagtgcay 300aggtagagcc atccttaggt agcctttaga cttaatatta ggtgagctct ccccacagat 360agcctctcct ttatttgaat ggaattatat tttaagtttg gaaatatttt tcagcttatt 420tagcctgttg aatttaataa aaataatatt taatcttttc agaggtcgaa acagtaacaa 480aggactgcct cagtctacgg tgagtaactt taatgttact tattggggaa aattagtagc 540taaaacatga tctctaacca cagaccaaat gccaaggcaa aagattccct tcttttgaa 599641599DNAHomo sapiens 641ttttgtattt ttagtagaga tggggtttca cgatgttggc caggctgggc tcgaactcct 60ggcttcaagt gatccacctg ccttggcctc ccaaagtgct gggattgtag gtgtgagcca 120ctatgcctgg cctaattggc ctaatttcaa tattgttata tctcagggaa tagagaggca 180cgaggagaaa gagagacaag ctgactgctg gttcgtggag tagtcataac acacaacatt 240tattaagatt gctgtcttat atggaccgtt tgtggtgcct taaaagaaat cagggtaacr 300tcaacgatta ctgattacag attactataa cagatacaat aataattgta aattattatt 360tacaattgta aaatacaatc ttttctttat tatttacaat tattgtaaaa tacaatctga 420ttacagatta ctataacgta tacaataata gtggaaaagt ttgaaaatat tgtgagattt 480atgagaatgt gacacaggcg caaagagagc acatgttact ggaaatacgg cactaatgga 540cttgcccgac tcggggtttc cacagacggt cagcttgtca aaaatgcagc atctgtgaa 599642599DNAHomo sapiens 642gattacaggc gcccaccacc acgtctggct aatttttgta tttttagtag agatggggtt 60tcacgatgtt ggccaggctg ggctcgaact cctggcttca agtgatccac ctgccttggc 120ctcccaaagt gctgggattg taggtgtgag ccactatgcc tggcctaatt ggcctaattt 180caatattgtt atatctcagg gaatagagag gcacgaggag aaagagagac aagctgactg 240ctggttcgtg gagtagtcat aacacacaac atttattaag attgctgtct tatatggacm 300gtttgtggtg ccttaaaaga aatcagggta acatcaacga ttactgatta cagattacta 360taacagatac aataataatt gtaaattatt atttacaatt gtaaaataca atcttttctt 420tattatttac aattattgta aaatacaatc tgattacaga ttactataac gtatacaata 480atagtggaaa agtttgaaaa tattgtgaga tttatgagaa tgtgacacag gcgcaaagag 540agcacatgtt actggaaata cggcactaat ggacttgccc gactcggggt ttccacaga 599643599DNAHomo sapiens 643agggataagt ttatgagcaa cgggtagatc gttgggagag acttgagttt cctgtcagga 60agcattcttg gtgcataagt cagaggtgat atgaatgccg tggaaggggg tggcttactg 120tctggagaac tcgagaagat gggaatgggc actgtccagt attgtggcta cttccacaca 180tggttcttta aatttaaaat tatgttgatt aaaatttaaa tatttcagtt cctcagccat 240actaatcgta tttcaagtgc ttagctgcca catgtgccta atggctgcaa tattggacar 300catgacatag gacatcttca tcattgtaca aagttctctt ggacagcatg ggactagagc 360cctaagatcc ttttctacct gagttgtttg gattttttgg tgtgtctagg ttggatctag 420ttgttcatgg cttcatgacc aagcctttta tccctttctc tagagggact caaggggtaa 480aggcactgaa ggggtaaaac ttcatatgaa gagtgtggtg gtggtggtgg tgttttaaga 540cagggtctcg ctctgtcact caggctggag tccagtggca tgatcctggc tcactgcag 599644599DNAHomo sapiens 644aacatctggg ccctgattgt gcgcatcatt acgaccattc tgctcagcat catcccagtg 60ttgatctttc aagtctatca acagatcagg aggcattatc taggccagga gctctgcccg 120tgatctgatt cccatgtact ccatccaccc tccattcctc gccctgcccc cagagccaag 180ttctctatca gccgtttatc ctcacacact tttctacaat ggcattcaat aaactgcacg 240tgtttctggt ttaaaaaaaa aaaaaaaaca ccagagccat tccaactcca aatgcgtttk 300actctacatt gttgaacatc tactatgtgc caagaacaga acataagaag aatttaggct 360gggtgtgctg cctcatggcc ttaatttcaa tactttggga ggccaaggca agaggagtac 420ttgagggcag aagttcaaaa ccagcccggg taacagtgag actgtctcta caaaaatttt 480tttaaattgt agggcgcaga cactttggga ggcgaaggcg ggcagatcac ttgagctcag 540gagtttgaga ccaacctggg caacatggta agaccctgtc actactaaaa atacaaaaa 599645599DNAHomo sapiens 645ctcctcggag tcccgcggtg gccaccgagt ctcgccgctt cgccgcagcc aggtggcccg 60ggtggcgctc gctccagcgg ccggcgcggc ggagcgggcg gggcggcggt ggcgcggccc 120cgggaccgta tccctccgcc gcccctcccc cgcccggccc cggcccccct ccctcccggc 180agagctcgcc tccctccgcc tcagactgtt ttggtagcaa cggcaacggc ggcggcgcgt 240ttcggcccgg ctcccggcgg ctccttggtc tcggcgggcc tccccgcccc ttcgtcgtcs 300tccttctccc cctcgccagc ccgggcgccc ctccggccgc gccaacccgc gcctccccgc 360tcggcgcccg cgcgtccccg ccgcgttccg gcgtctcctt ggcgcgcccg gctcccggct 420gtccccgccc ggcgtgcgag ccggtgtatg ggcccctcac catgtcgctg aagccccagc 480agcagcagca gcagcagcag cagcagcagc agcagcaaca gcagcagcag cagcagcagc 540agcagccgcc gcccgcggct gccaatgtcc gcaagcccgg cggcagcggc cttctagcg 599646599DNAHomo sapiens 646ctggaggtgg aggttgcagt tagccaagat cgtgccactg tgctccagtc tggacaatag 60agctagagac cccttctcaa aaaaaaaaaa aaaaaaaagg gaaggctggc agagggtgga 120tgttcaggac cctggactca cacaaaagtg gcctcaactc agtactctcc tttcccaaaa 180caacaaaatc gaactaggag ctgtgtcttt tacattccca agtcccaaag ttaggggaga 240tagtagagca gagtggtgat aagcccaggt tttggggtta gatgatgtca agattgagar 300ttgactgagt gtggtggact gcaactgtca tcccagtgct ttgggaggcg gaggtgggag 360gatcacttgg aattcaaggt cagcctgggc aacatagcaa gatcccatgt ctacaagaac 420aaacaaatta gctgggcatg gtggtgtacc tgtagtccca gctactcagg aggctgaggc 480aggaggatca cttgagccca ggagtttgag actgcagtga gctatgatcg cgtcactgca 540ctccagcctg ggcgacagag accttgttta ttaaaaaaaa aaaaaagaaa agaaaagaa 599647599DNAHomo sapiens 647tggttgttat ccgattggag ctcgcggaac actcgcctgt ccccgccggc ttcggcttca 60gcgccgcggg tgagtcccgc ggcctcgccg cattccctgt agccgggtct gggcccggag 120ggcttccctt cccaaagcac tggcccggga aaagcccgcg gcgagggctg ttgcccagga 180agacacggag aggtaatcgg gatccctctc tttcccatcc gcctttgaga ggccttcccg 240tttgttatct cagggaagcc ctgccccgaa cctccctccc tgtgccgtct gagggcatty 300agtttatacc tggcgcgtct ccctctcgag atagtcgagt ggtgtgtttg tctcacttgc 360ttccctatgg gcttcgtaaa ggcagggact gggtccccag caacgctgga cggtccctgg 420gttaattaaa ttgttccctt ttggaacgat atccattgaa gtgcccccta accatagtca 480taactaaaat

ttggacactt cctatatccc agcactgtac taagcacctt ttgtgtattg 540tattctttaa ttatctttgc aacagcccta agaggcagat ggatgtgaca tgtacctct 599648599DNAHomo sapiens 648atttaaggga caattgaata gaattttaaa atcagagagg aggagccatg tttgtattgt 60tcacttttgc attcctggca cctagcacct tagcatagga tcactgttgg gtaaatattt 120attgaataat gaatggttgc catttacgaa accatgttta cagttttgtg ctccagaagt 180gaggtaaagg gttgcttaat gagaacccag tatttctact caaaaggacc ttattgcaaa 240gtatttggaa gtttaaaaga gtgggaacat ggggacgcat agggagtggt gaaactggcy 300cagggaaagt ccattgcagc aagatagagg ttgccaaacc gtaagcagaa caagttgaaa 360ccgcgcctgt ctggcaaaca gtccaaagtg gaattgaaac tcccatcttt gaagtggtga 420aaaaaggccc tggggtgggg gagtggggca gagggctggc gtctgtctgc ctgggttagt 480cttggttcgg gagtgtcccg agcaagcctg gggagatgac tgcccctcgc cttgatcccc 540aactaacctg gggttctgga ttatgtgtgg ggaagaggga atgtgtgtgg cattccgtg 599649599DNAHomo sapiens 649caaccatcac cactaattct ataatattgt cattgcctcc cctaaatatc ctgtacccat 60tagcagtcac tccccattcc tccccctacc aggcccaggc aaccaccaat ctatgttctg 120cctatagatt tatctatttt ggacatttta tgcaaatgga atcctacatg gttctttgtg 180tctggcttct tccaagtagc catgttttaa aggttcatcc atgttgtaat aagaatgtat 240cagaacataa aaggccaagt aatattccat tgtgtgaata gaccacattt tgatttttcy 300attaatctgt tgacagactt gattgtttcc accttttggt tactgtgaat agtgcagcta 360ggggcactaa catttctttc tttcttttga gaccgtctcg ctctgtcacc caggctggag 420tgcagtggca tcatctcagc tcactgcaac ctccacctcc taggttcaaa caattctcct 480gtctcagcct cctgagtagg tgggactaca agtgcacgcc accacgccct gctaattttt 540gtatttttag tagagacagg gtttcaccaa gatggtcagg ctggtcttga actcctgac 599650599DNAHomo sapiens 650atttctaggc tgtctggtct tggaccacct actctcccaa gcctgagatt ctttaagcta 60gcattagcaa cacctgtttt tcagcatgac tgtgtgggtt ggaagtgata tatgtatagc 120acctggtaac ctgctcactt agtgccaata attattccgg gaggtactta atgctgtggc 180acctgttgta ttctttgtac tgctggagta aaatacttcc tgcagagaga gaccagactt 240actgtggata acatgatttg ggatgatttt atctgcaaat aaaatacaga atccaaacar 300aatcacatca acctttaaac tcagcggcac tgcccccaaa ctttcagctt caggattgga 360atggaagtct gactgaggga cagtttccta tgttgcccca gaatattctc ccgtggctcc 420caccttatat actccacagc ctcccgagtg caaagcacag tccctggcct atggcatgca 480cccagtatgc cacatggatg tgcaaagaag gaatggaatt tctcttttca aatatctacg 540tgaccaggca cctgctctgc ttttctttca gatcttccca gacccgtcag attttgacc 599651599DNAHomo sapiens 651tccatatact tatgcatata ttggtgcctg tgcatagata ttaatattat tgatatgtgt 60atagatggat aggcagtatt ttacacctct attagcaaca aaaagtaccc attttgcatt 120ctcttatcat caagaatatt atattttaag aagatcaaag tattacagat caatttatag 180gcctaaattt ctatcacttt ttagtttact tagctgttcc attagtcact actaaagagc 240ccacgcctcg ccccacccct tacgttggca ttttacattt ttttttagca gaaacattcr 300tattattttc ttaactgata tttttggagg ggtgttagtt aatatctcag tgatttaaga 360atattcttaa tattgtgatg tttatacttg agttgtcaca catatttggc atgattattt 420gtttttcctc tgatagagtc agctttcctc tattctgggt tacagtaccc ctattttttc 480ccatcaccat ccagctacat gtaagttgta gcatgtagct gagacttaac ttcatcggta 540taaccattct gaggccataa tgataacgct gttgattagt aagtgccata aaaagaacc 599652599DNAHomo sapiens 652tttattttgt atgtaactat ccagatttcc aaccgtttat tgaaaaggct gtctttcctt 60cattgtgtgt ttttggcaac tttgtcaaaa atcagtttta actgcctaaa tttatttctg 120tgttctcatt tctgtgccat ttgtccatgt gtctattttt atggtagtac aattttattt 180tggttattat agcttgtcgt ttattctgaa gtcaggtagt gtgatgtctc cagctttgtt 240attttgctca aggttgcttt ggctatttga gctattgttg ctctatacga aatttgtgay 300agtttttctg tttctatgaa gtatgtcatt tgtattttga tagggattac actgaatatg 360taggacactt tggttaggat ggacatttta ccaatattca ttcttccaat atattatcac 420aaaatatcct tccatttaat tgtctcttat ttattttctt tcaccagtgt tttctagttt 480tcagagtaga agtttttcac ctccttggtg aaattttgtt ctaagtattt tatttttgga 540aggtattgta agtgtgatag ttttctttat ttcttttttt cacatagttt gctattact 599653599DNAHomo sapiens 653gtgttagcta ggacggtctc gatctcctga cctcatgatc cgcctgctta ggcctcccaa 60agtgctggga ttacaggtgt gagccaccgc gcccagcccc aaccaggtcc agtcttagga 120atagttgtta acatcacttt tgatatcagc atttactaga tctacaagtt agactcagta 180tgtccctgct tttcaaataa ctataaacaa caaccctaag ggaagaatgc cttggatgag 240tgtaattatt tgagcgtaag caaaatgact ttatttaaaa cagtaagagc ctggtgacar 300taactccata atagaaaaga aacgtgaacc gcagcacccc gagcgtgacc gaaaacaagt 360gtaacaactc gcatcgcctg acctcagcgt ggggacccag agaaaagcac tgtcttccct 420cccactgggt tgcttcccag actttccttg aagcacccag ggtgttctgt tcttgaaaaa 480aagatggggt tggcacttcc ttcgctaccc tggtacaaag ttcacagaga tgctaatctg 540atccaccctg gaacatttcc tccctcaata aaattctctc tccaaagaca aagcaaaca 599654599DNAHomo sapiens 654ataaatacct ggttcctgct gtgccctcaa taaatatttg tttaattagc cctttcagta 60aaataaattc aaagaaccca gttgtttaaa ctcacttaca ggaaactttt tccgtatgct 120ccaagtacct ggagttttgt tcactgtgga ttctgatctt gaaatccgat tactcaaagc 180ctgccatatg tccttcagta atttgcaaca caacagttac atggttctgt tacagtaccc 240tactaatctc atcctggact gggcagaaga cactgtgtca gtaattaaat ttatatcacr 300gactaaacag agtttctttt tgtttttact ttgttctggt tttagaaaga agcacacagt 360gcagacattt cagcaggtac taaaagtgta ctctcagaca ctgtcttctc ttctgtaggg 420tcattcatat gggaatttaa ccattaattc taaaaagcag agaaagtagg agagtagggc 480aagctagagg taaggaaggc aaacacccag aacaggggtg ccaccccacg gaaataagga 540agtgcagttg gccccatggt ccctggtctg acttccccat aaagtgacaa tacatagag 599655599DNAHomo sapiens 655tctgtttgcc taacagctga ggcctttttt atctagcctc gtacatgcaa actgcaccat 60gtaagatgtt atatcccaag cttcttcctc gaaaaaaatt gcctaaatag agaaacatgc 120ctacggaagt caagagcttt ctgcaatttg catttgtgct gtattaattg tggctgaggc 180ccacctcagc cataggcaaa aaagctgcca tccgtaagat ccattttcat gcatttaaag 240aacaaactac tcaggaatga ttcccttacc tgagtgagtt tggtacttac agaccccagy 300ttccagaatg gaggttgatt ccttctgctt gaggcattag ggattaaaag cagttggctc 360tgagaaggct tatttagtaa accttagaaa tcttttacac ctgagtgttt ttacttcccc 420catgaggtct ccaaagcatt tttcaactga gaaaagggca ggagagtatc tgaccaggca 480gagcaaactc gctcctgtac ctaaaacacc tgctctgacc acaactgcaa ctcacaagtt 540agagcatgct ccaggtgcag aggacagtgc gaggatgtga tttaagcatt agatccagc 599656599DNAHomo sapiens 656aggtgagttt actttaataa gtcaactaat aggtcgtcag aagacctgta gcttgtagga 60atactgaaaa gggattgggg gtacacatgg agcccaagcc ctagaatgag agccatcccg 120acaagccaca aactgtaggg cagtcgcaac aataccacaa ggataaactt agggcaaaat 180tcagaaaaga aattgtggta acagacttgg gacattgttc aggagtcagg acctagtggt 240tgagaacgtt taaaaggtgg cttccttgat gagattggag ggaaagtcca agtcaactgr 300aacatcattc tttatcattc ttgtgctgta atccgtttct aaaactgccc tggctattca 360tcggatagct tacatctaac ccttttctac ctttttgact ttaacctatt tatggagatt 420gtgatatgta gcttgcatcc ttcccaggac tatttgaaga gtgataagag ataatgcagg 480tgacagcact ttgccagctg aaaagcacta gacaaaggtg aggctccagc atcacataac 540ctgcaaccct acttgctgag gccaggagag gtctgggcca ggagatgctc tgtccccag 599657599DNAHomo sapiens 657aagatctgag tccaaatggg ctggcctcag gtgatgggag cttgaaaata ttcagaagtg 60atgatgccat taaataatgc ttatttccta aattgcagta gcattggaat gtgtctactc 120tatgtgccaa gagctatcta cttttgcata atttttaaca tttgcatatc atcaaaaact 180tttcatagtg cctgttaggt ataagatact ctatgagtta ctggactggg gatggtagca 240gaagctgggg aaggatttag agaaaacttt ctcactctca agaggtttga aaagtaactk 300gaaagacaga gcaggtaaag aggggacaat attagccaga tgtggtggtg tgcacctgta 360atcgcagcta cccaggaggc tgaggcagga gaatcgctgg aacccaggag gcagaggctg 420caatgagcca agatcgcacc actgcactcc agcctgggct acagagcaag actctgtctc 480aaaaaaaaaa aaaaaaaaaa aaagtaaaca atacaaggta cactggtgga atagacaagg 540gtcatgggaa gacagaggca aagatgagag ctacagagtg gttagtagaa gaaaatttt 599658599DNAHomo sapiens 658agtccgggag ttcaagacca gtctgggcaa catggcgaaa gcccattgct acaaaaaata 60tggaaaatta gctgggtgtg gtggtgcatg cctgtaatcc cagctactcg ggaggctgag 120gcaggaagat ctcttgagcc caggaagtgg aggttgcagt gagctgagat catgccattg 180ctctccagcc tgggccacag aagaaaatcc tgtctaaaaa aaaaaaaaaa aaaagaaaaa 240gaaagagaaa aagagaaaaa agaaggaagc aaccagcaac caggcaaact aagatttagy 300atgttattga atcagctaat tcttagtttg gctttataga ttggctagat tattcacaag 360gcaatgttaa gcataaaaaa tccaaaaggg actgctttgg gtgaaaacag acaaaggaaa 420cataaccaaa agtaatatat gatacttgat tagatcctaa taaagcagcc tataaaatac 480attcttgagg caaatggaga aatttgaata tagtccttat agtagattat atcatagaat 540tattattaat attcttagtt atgataatgt ggttagtaga agaatattat tattcctgg 599659599DNAHomo sapiens 659aaaagtgaat ggagtagaat ttattaagca aaaaggtaag ctctcagaga aaagacgggt 60cctaaaagca ggttgttggt tgcccccttc acagttgaac acaagggctt ttatatatcc 120gctgatgggg ctgggttccc taggtgtata aagcgccaat tcctggcggc tccaccctgt 180tcttccagtt gtgcatgccg gccctttgtc tgagccactc cacattgatt tatatccctt 240actgcgcacg tgttgaggga cggaattttt caccaacggc atgtttaagg aagcccctgr 300gcacaacgtc cttggcgggt gggagcatct gcagagaccc tcccatatct gcctaggaga 360gttctctggc acctgcctct atcgatactg ttcagatatt atttggaaat atctggttaa 420tggctttgta gcatctcatt gtatgaacta gatgtataca cttttaaggt gagtcaggcg 480cggaggaagg caaactactt gcagcacact tctgagcttg catttctcta cctagactca 540ccatattcta acaagagtta ctccagacat ctcctgaaca atatcaccag cacttctac 599660599DNAHomo sapiens 660aagtgtttct gtatttaata acacagaaaa aactcttgac tgattcatta attcagtatt 60tttcagtact tctaacatca acctccatgt gacatttctt tgggcatgct gaaccattta 120aagctttgct tcctctgatg tctagaggtt cctccttttg ataggtgtgt aagtgatggc 180atcttccttt acaactctgg ctaccaggaa gctcaggcaa atttgaaatt taactacatc 240aatgatgcag cttttaccag ccacatatat atatattttt tactgttttt aaattgaacm 300gttgaaatat aattttgtct tcgcctgttt aggatgccgt aacaaaatcc tataggctgg 360gtggtttaaa caaccaaaat ttattttcca cagttgtgga gggtagaagt ccaagatcaa 420agtgccagca gggttggtgt ctggtgaggg ttctcccatt gggttgcaga tggctgcctt 480ctccctaagt cctcacatgg tctttcctct gcgcaagtgc tcagaaagag ggaaagcaag 540aaagagagag tgagccatag agagctcact ctctggtgtc tcttcttgta agaacacta 599661599DNAHomo sapiens 661gatgataaac ttgcaaaata aagcaaacta atatttaatg aacgcttgct atttgctaag 60cagtttacat atattattgc atttaattct tataaacagc cctttaaggt ggattttatc 120ttagaattta atcatgattg tgttcctaag gcctagtgca atgcctggta catagtgggc 180acttaacaaa tattgaatta agttaaattc cataaaatca agaatgcata gctgatctca 240agaggaaaca tctgcaaatg cttacctcca cagaatcaaa tatcactgct ggtacagctr 300tgttgttcat ttttgcagct ttttggatga tatcttcagc ctctctaaat cttctctggg 360atatcagcca tcggggagat tcaggaatga acctataatt tatttttaat atttaataat 420ttttcacaac agcagggctg gatactatta aatctgagtt tcccccaaat agttttaatt 480ttgtaaaatt ctagtttgtc tttttaaagg gagtccacat aagatttcta ttggagcata 540ggaataaata aaaccacctt caagtttcaa acttctgatc aaattataag accgatcat 599662599DNAHomo sapiens 662gaggatacca gttgacagga aagaatgaaa agccttatga taatgcaaaa ggattataga 60catgcacaat gtcatctgcc aaaaagaaac tgatattttg cttacttttt tttctctgaa 120aatgttcaga tttaaatcca ttctcttata ctgttcacca acttcacaaa atgatgctca 180agagtgccca gagagtcctc ctatctgatt gatgttctta tgtcccgggc tttacaggtg 240cttacaacag aatgctgccc tacatcgtca tgggtagtct gactgtcctg attggaatcy 300tcaccctttt tttccctgaa agtttgggaa tgactcttcc agaaacctta gagcagatgc 360agaaagtgaa atggtaagta ggacttttaa caaaatgata ccaaaatgcc ttagggagaa 420taagcatgga agaatagcta ggaaggttct gaaatagaag agtaataagt agagactagc 480tctatcagat aataaagcat attgttggct gggcacagtg gctcacgcct gtaatcccag 540cactttggga ggctgaggca ggtggatcac ctgaggtcag gaatttgaga ccagcctgg 599663599DNAHomo sapiens 663tgcggctgta agagtgtctc aacgagccca gtggggagtt ccagccaaag attgcccagg 60agaagagtcg cactttgggc agaaatggac aggcccgagc aaccctgcca tgttctgtca 120ttggctgggg gccacccagg aggcaacatg gtctgacttg aatggtgtgg atccgaggct 180gcagcctgtc agctgtctgc actccatgca acaggtcctt tgaatggcat gtgttcgtgg 240ctgccataaa ctgcagcctg ccttttagcc ttacctcctt tgctcttgct ctctgacccy 300gtgttctggc aacactggcc tgactacacg ccgtatcaca tacaaccaac tgcccatacc 360aaccccaacc ctgacctttg ctcactcagt tctttctgcc tggaatgcca ctccttccca 420gttataccca gcaaaatcct aatgtgcttt caaggcccaa cttaaaaatc atcttctctg 480gttgacctca ccatgtagaa ttaattgttc cttgctccta tggtgctatg tgtatattag 540tacttcccag attggagtat tcttagctgt ttttttctca gatttttgcc tcctctaaa 599664599DNAHomo sapiens 664aagtggtcta tgaaggaagg aaagtttggg tccaggtcat gatctctgca atgagctgtc 60ttggtgtcct taggcaagtt acttaacctc tctgagcttt cacttcctca ttagaaaaat 120ggagatgata ttaaccccaa agcatggact gattaaaatt ttacatgaga tgtattgttc 180tattttgcta ggaaatagga tctcagtaag catctcccac agttgcctgc ccagtatttt 240atcctgtgaa ctaataagaa aggtgcctta taagtaaagt gactgtataa tttattgtcr 300aaaccaaaac acctttgtga ccgaagaagt ccactcttaa taatcacgcc aaaacaacac 360acagaaactg gaatcgtccc aggagaacaa gtcactctac ttacagagac agttagggaa 420atttctggtc caggaaaatc agtgggcttt gctgacaagg atgtccagaa gcttctaaga 480gtagatttga atgaaacctg aagttcacag gctaagaaaa acagacaggc ttctttagac 540gtaaatgggc tgacaaagag aacaatttag tttggccctg ggaaataatt gagttagta 599665599DNAHomo sapiens 665catcctcagg ctgtcagggt gacttcagat gagcctggag ctgagctcag ttccggaccc 60caggtcctgg ctctgtcaat gccggactgg tccaatctct atgccaggtc cttccaaccc 120catccctctc tttatcaaag taggaatcaa gaagatccga aggctcaggc tctcaggttg 180ttagagagta ctgaaattgg aggctgtgga tggctgggcc ctgccgtgct cccggtccag 240ctctgactct ggtatggccc cagctccttc ctgtaaaatg aggggataaa aatcttcagy 300agccctgtgt aaacttctgc aggctctgtt aacaggtcta ggaggacaaa ttgcagggct 360ggtgtcagtc actctagact ctggatcccc agggcacatg tcctccactc agcagaggct 420gcaccttctc ctacctgtac ctcagtacca gctccctgag cttgaggcag aaatttctga 480agactggggt ggagcgccat gcggaggggc cgtagaggaa cagacgagcc agaattcaaa 540tgaggacggt gatggcactg cagggccaca gcctggttta cctgccactc ttccaattg 599666599DNAHomo sapiens 666gaaaggcaga gcttggcact caaggtatcc agggcaagct gtaccctcca caaattctgc 60attcacttcc tgttttgcac attatttata tttctatttg tagaaaaaaa tccaagagtc 120tcctgttcac tagcagagga gagaaggtat gcaacatcct tgcagatacc ttctctctgc 180tcaggagagt taatgaactg gactttgaga actcacttcc agccaggtag atgcaggaca 240ggactctgct attgggtgca gtacccacct ctgagtctga atcttacccc accccatccy 300tccctccatg tacaggtctc ttctctccct aactctccct tcagccctgg gaattctctc 360tccttggcct catctcatcc ctgaggctta tcttataggt aactcactct atctcttatt 420ccaagtttat tatttacata gcttggaata gaagggagtt agagaggaaa caagggtggg 480agaaaaaaaa agaaaagata gttatgtgaa tttaatttag gcattaagga aatacccctg 540acaaaaactt tactatgcca gtggggccac atcaaaatgg cctcggcagg ggaccctgt 599667599DNAHomo sapiens 667aggagaattg cttgaaccca ggaaacagag gttgcagtga actgagattg cgccactgca 60ccccagcctg ggtaagagag ctagactctg tctcaaaaaa ataataagac aaaaaaaaag 120ggcatggatg agaggaccag agggattccc agtaaatgac aaggtgaaat aagaatacta 180aatagtttct gagaatactg atttaatgag acaagaaaat aagtcagaca ctttgaaaat 240tcctactaaa tgacttgaaa caagaaataa caatatgtag atgtagtatc atgtatgttr 300tgttttgtcc ttcagaaact gtgtactgtt cagagtgtca actgcagaga cattgaaggg 360cgtcagtcta caccacttca ttttgcagct gggtataaca gagtgtccgt ggtggaatat 420ctgctacagc atggagctga tgtgcatgct aaagataaag ggtaaatgcc aatgattgtt 480atggactctc ttccttactt ttacttgacc tttttaggaa aacctggaaa tataatatgt 540tttatttttc aagaaagcct gtttcctaac attggcctaa atattaaata gagcttctt 599668599DNAHomo sapiens 668tattctcctc gagggcaggg tttatttgat atttttctgg agcttagaac cataagcctg 60gtgctgggga ggaagcgccc ttagcatttg gtagcctctg tgggcagagc atggaaagtc 120acaacttctg aattgtttgt attttcagtc tcactctaga tggatggcat cttctgctat 180gggaaatgaa atatgtttag gcaacttgag tcccaggtgc agatgaggct gggctaattg 240gtgcactagg gaaggagccg ggggagagat gtgctgttag ctattatcaa tctgtgacar 300ctgtcagctg ctggcagtta gcacccacct gagcctggga tgcaggggtg cctctcctgt 360cctctgtgga agcctctgga cccagcagcc atcttgactg tgcactgttc aagccccaag 420tccgcctgga agaggtgatt gagaacttac tgcaggataa ggaaagcgca ggacaggtgc 480agtggctcac gcctgtaatc tcagtgcttt gggaggctga ggccggagga gggctggagt 540ccttgagtgc gagaccagcc tgggcaacat agtgagaccc tgtctttaca aaaaggaaa 599669599DNAHomo sapiens 669agcactcaaa atctgaaggg aagtaagtgt tatatggggg aagtaccagg agttagggga 60gcatataaca gtgacaacta atccagtcta gtgatcaagg aaggcttccc tgaggaggtg 120gcattaaagt caagacctat agacaactga aaagatgggt aggagtcatt ctagcagaac 180cactcttaga tagctctata accccaggat aactgcctaa tctccctgga actcatttta 240tctttagatg tggataataa ttagcacaat agacagcact caataagagt tggttctccy 300ttccttcaca ggaaggtggc cttccaatct aacgcaccat ctatgagaaa aagagtaggt 360atatgtagag tctaataaca caaaccataa ttgttctttt attcattctg taatatttct 420tgagcactgg ctgtcaagag cttttctaga catggatgtg cagttcctac tcatcaattc 480taatagagaa tgtatcggtc aggatggact aggttctgct gtgtaacaaa cacaccaaaa 540tcccaccagc ttaacacaac aaaagtttac tcctccctca tagagtctgc tgcaggtct 599670599DNAHomo sapiens 670agccagggag gtgaactgta attaaaacgc agatggataa agcaggtact cctttaacat 60gcaaattgag atcctggcgg ccagcaagct ccattttgag cctgggcggc aggctttctt 120agagggggct ttgttagaaa ggcagagggc tttgttagaa aggcaccatg aaggagtgga 180aggaatgggg attaaagaag gttaaaggac ttggttaaag aggccaacaa aaccctccca 240atggctgagt tgcaagtttt taaattacta ttacctactt gagacatatt ttgaaaggcr 300tgaagaagaa taaatggccc caggagcaga ttaagaagta aacatcccca gtctatctga 360aggctcttgt gtgccccgcc tcagcaatac ccacctctgc ctctgcagag ggagcctcta 420ttctgaagta ggtgttactc cagcctcatg ctgtttttat acttttatta cctatttggc 480tggtttgttt attttttgga gacaaagtct cgctctgtca cccaggctga agtgcagtgg 540catgatcaca gctcactgca gcctggacct cccaggctca agcaatcctc ctacctcag 599671599DNAHomo sapiens 671aaccttggct tcacactaaa accacccagg accttttaaa aataacaatg cccggttctg 60cttcaaacta attacatctg aatctctggg agtggagctg acatcagtat tttttaaaag 120cttcccaggt ggttctggtg gcagccaggg ttgaaaaagc actttgcttt attgttttct 180ccctcaaggt agtaactgga tctgcttatt gacaacttta tccccaacac ctagcctagt 240gcctggcact tagtaggtcc tcagtgggtc tttttaatta attcttttgg cacaggtagr 300ctattcacct gatttttaaa atatcaaaag gtatacagtg gaatgtcttc ctccttacct 360tttattcatc tagttctcac ttctccccag tcacctagtc cagggggtca ttgttatagt 420ttattccagg

ataactttat gcaaagataa gtaaaattga atatatatat gtatatacac 480acacacacac acacacacac acacacacac acacacatac atatgcatac cttgttaaat 540acacacatat gtgtccgttt aagtactgtt gagttattgg ccctaatcct ttactctct 599672599DNAHomo sapiens 672gatttttttt gtagtgatgg ggtctcgcta tattgcccag gctggtctct aaatcctggg 60ctcaagcaat cctcctgcct tggcttccca aagtgctggg atcataggca tgagccatca 120tgctcggttt attcatgttt ctaattgtcc tcccatcttc tagagggaag ttaatataac 180tttgatattt gaatttttac ttcgtgattc atgtggcata ctgagtatga aaatcatctt 240cctccctaaa ggccatcgtt ttttctcccc atgaacattt atgccaaata ctgttttgar 300tttaatattt ccacatcccc taagcagaac ccagtctgac ttctctctct tttttttttt 360ccctgcctct gagtctacta tgagaaatga ttctgactca taaaattgat gtatctatag 420aacaaatggc agttgtggcc cctcctgaag atgactcttt gggtttccac actttctgga 480ttggacttga attccttggt gtcattttca gggcctcctg cggctttgcc ccacatatgc 540ctcagaccca tgcaaatcaa gtcctggatt ttctggctat ttttactcta acacagaat 599673599DNAHomo sapiens 673aacaccaagg catctttgtc agttgcctca gctagagagg tgacgacagg gccaaaagcc 60gagagaatgg gatgccaaga ggtggtgtga tcccagaggc cttcaagtta gaaggactct 120ctgagaagag atccttgttt tccatcactg cagagaatgc tataccaagg gcgagaggcc 180tctaggtcag agatcataaa gaagaaaaga atggctggat tttaggggtg gtgcccaacg 240attagtttgt gttgtaatgt ggcatgaagc gtcttcagaa tgcatttgcg atgtttactr 300ggatttggaa aaggatcgta acaaggtcta gcaaggcagt ctagcccaag gagggtccag 360ttgagttccg aactagtttc tgatatctat cccttccaaa actgcatgtt taattaaaga 420acagccctcc tctatcttcc ccagatagag gagggctgtt cttcagtcga agatatggag 480tggttgtgtt tctctaccaa aacctttatt ccattttctc aaattttagc atacatcaga 540atcacctggg gggcacatta atacacacat tatggaccat atactgtatg cctggcatc 599674599DNAHomo sapiens 674taagacagga ctttctgctg gtttacctta gttttgtagt atccagtcaa agggcaagag 60ctgtttccct cagttctagt tttgtccctg aaggaggaag aaacttcttc ctggctggcc 120ttggatccac cccttggtct ctggcagcca cttatcgact gttgtttgtt ttctggggtc 180tacattgaaa gatttcaatt gcttattcta tctctggcct agagtcctac tcagaaggaa 240tttattttga ggcttttcta gcttcattta cctaaacatc atattttaaa acaaaaaaam 300atttgtctcc ttaaacctgt ccactggatt tctttcatcc tctatagctg gagatgacag 360tgccaggaaa tgtgattacc ttagctgctt tgatgagcct attagatgga agtatggtta 420aaaaaaatca acatcataac ctaaaaaggc cttctattaa agacgggaac ctccaccttc 480aacacacaca catacactgc acatatacac atatacattt gcttttaacc cacaaaactc 540agacactccc ctgagggtag agagtaattt tgctcttgta taccgtaaat catgaaaag 599675599DNAHomo sapiens 675gctcagaggc agtgaagcat cactttcttt ttatcaccaa agaaacctct ttgacctatt 60cttgcaattt ttctataagt gcaagacgac attaattttt aaaaaaagaa attaagaatg 120ttatctcttt aggccatccc tatcccatgc agacacctac tttctattta gactgagtta 180ttcaggaagg agggaagagg ggatggaagg aaggatacaa gaacatattt agaatatatt 240tttatggaca tattttatga ctatttgggg tatatataaa aattatgaaa attcagttcr 300ttaggcataa aatggcataa aaatatccat tgtgtctaag ttgataatga ttttactcaa 360attctccata tctttgttta cttttcttct tcaaatgacc gtttttgaaa tagtatgttt 420aaagcctctg ctatgattgc agttttatca ccttcctgtc tatttataac aggttttttt 480ctttgcactt agtttgaatg tagcccaact tcttatgaca acaagaatat taatattttt 540gcagacataa ttaatgtatc ataaggaagt cactatcaag gtcaaagcaa gtgcaggta 599676599DNAHomo sapiens 676actggacaag acgattcatg aggattggaa cttcatctat tttctttatg ctttattcct 60cagcatgaag ttttgcacat attaggcact caataagtaa gtatagaatt agcatttatt 120gaatctcaat aatataaccc cagacatcag atttgtctct attcatcagc cacacagatc 180tgatcatgat attcttccac ttcacaatct ctgaatggac tcgcattgcc tacttagaaa 240gtgaaatcta aatcccttcc aatggcatct aagggcattc acaatccagt tcgccgtacr 300tgatgatgta gtaaaatgtc agccaggaaa cttaggaaga gaggaaaaac agaaagtatt 360agtaccattt ccgccactct gccctctgta caacagccac attaaactat ttattgtgac 420ttattattat gactatgaaa ctgtcatttc attgctccat ccaccaattt tgaaagtgat 480acctttttac aagtttgatt tgcatctcca gtaaatgtag agagctgaga tttccccaca 540tattttaagt aaatgacttt gtttttgtca tttttgctat gggtatatgg gtatttcat 599677599DNAHomo sapiens 677taactaaaaa tattataaat gttaaatatt taaggagaga gacactataa aaaatctatt 60tctgcaaatt tataatgtgg atagaatgaa tcaatttctc caagacacaa agtacaaaaa 120attcatgaaa gaaatagata atttgaatag attttcattt tttaaataag tgaaactgat 180aataacctaa aaaatgacac cttgccaatt ttagtttcac tgtttatttt gatcaaacat 240ttaaggaaaa agtattacct gttgtccaaa atttcttcca gaaaaaggaa gcaaaggacr 300tacttcctaa gtcattcttt gaggccagca ttatgctaat actaaaccat atgcagacat 360gcataagaaa actatagacc aatacctctc atgaacacag aggcacaaac catcagcaaa 420atattagcaa ccctaatata acaatgtgtt acatttatta cagaccacat ccaactggga 480tttatttcag gtacaaaggc tggttcaatt ttcaaaaatc aattattcta atttcaaata 540cactaacaat taacaatcaa aatttgaagt taaaaaatac atttacaata gcatccaga 599678599DNAHomo sapiens 678cgctgccaga taacaatgct ctcgttgtct ctttgctccc atctctgggg gcctctgatt 60ctttctgctc tacaggcacg cagcactgac agcctggatg gcccagggga gggctcggtg 120cagcctctac ccactgctgg ggggcccagt gtgaagggga agcctgggaa gaggtgaggg 180tgagggagga aagggctcag ctaggagctg gggagactca aggagctgct ggtgacgcat 240cccctgtctc ccaggctctc agctcctcga ggccccttcc cgcggctggc tgactgcgcy 300catttccact acgagaacgt tgactttggc cacattcagg tatgggggct ttgcatttgc 360acccaggagg gaagacaata tcctacccaa ccttgcaacg atatcaggtg ctttgcttct 420gaaacttatc cctgtgactg gctgctgcac gcgtctgagc agtcagtagc aaaagttgca 480ggagccacag cagatgggga gagctgctca ttcattcatc catttgttct tttattcatt 540caacaacaac ttttgttagg tatctgctct atgtcaggga ccaggacatc accaggccc 599679599DNAHomo sapiens 679ggcccaccag ctctgagcag atcatgaaga caggggccct tttgcttcag gggtgagttt 60gaggtctgat tattgtggca cagatttgag gagtgacacc ccgttctgat tctgcaccct 120cactccatcc ccactctagt ttcatccagg atcgagcagg gcgaatgggg ggggaggcac 180ccgagctggc cctggacccg gtgcctcagg atgcgtccac caagaagctg agcgagtgtc 240tcaagcgcat cggggacgaa ctggacagta acatggagct gcagaggtgt gggcccctgr 300ggacccagaa gtccagccac tgggctcctt caggacacag gactctcagc cccgcattct 360cctcctcccc taagaactag gagtctgggc cccacaactc agcgcaaaca ttccggactc 420ccagccctcc tctctgccag gatcttaaaa ccctccttca gggagtcatt tttcccacct 480tcctaaatgt ctgtcttgtc cccttccctt gtcccccgtt ggcctgttgc ttttcatttc 540agcctggctt ggggctcagt ctccttatct ttagtgtgcg gtggatgcgg gaattttcc 599680599DNAHomo sapiens 680gttaaaccag gccttggaag catgttctgc agaggcagcc ccttgcatgg taaggtgggt 60ctctgtattt gttatcggtg gctgtgtaac aaaccaccct gaaatgcagc tgcttaaagc 120agcacccatt taatatataa tggtttctgt gggtcaggga tgctggtgtg gctgaactgc 180atcctctgct tcagggcctc ccactggccg taattcagat gttggctggg gctgtggtct 240catctcaaga cttgaccagg gcaggatcca tttgtgagca agctcagttg ttgtgggctr 300cattcagcta cttttggact gttgaactaa gggtctcagg ttgttgccaa ctgttggcca 360gaggccgccc tctattcctt gcaggtgggc ctctcccata gggccactca cagcctggca 420actagcttca acaaagagag caggtgatgg aacaggagag ggcaaacaag atggaagtca 480ctgtctttac taacctgatc tcagatgtga catcccctca ctcttgccca ttctgtttgt 540tagggacaag tcactaggtc cagcacacac tcaaagggta ggcgattata ccagaatgt 599681599DNAHomo sapiens 681gctcaagtaa tcctcccacc tcagccttct gaataccggg accacaggcg tgcaccacca 60tgcccagctt tttttttttt tttttttttt tggtagagac aaggtctccc tcttattgcc 120caggctgttt tctaactccc aggctcaagt caacctcccg cctcggcctc ccaaagtgct 180gggattatag gtgtgagcca ctgcacccag ccagaaatac actattaaag ataaagaatt 240tctgttatga taaccctaac taacctgcca catcaaaaaa gctcagagct gatgactcay 300tcacctcaaa gggccaccat caaagagaca ggctcagagc tactacctcc aaatgaatca 360gctgagccac aggctgatta agtgactaag taaatccaat gtttactgtt ttagagcaga 420catcatctgc aacacaaagt caataaattt aaatgtaccc atatatcatc atcattctca 480acttggatga ttttgaccct catttggtca tgtctggaga cataattggt tgtcacaact 540gtgaggggac aggggtacta tagaaatctg tagcatgctg cttaacctcc tacaaggca 599

Claims

1-22. (canceled)

23. A method of assessing an individual for probability of response to a therapeutic agent for preventing, treating, and/or ameliorating symptoms associated with myocardial infarction, comprising: determining the identity of at least one allele of at least one polymorphic marker in a nucleic acid sample obtained from the individual, wherein the at least one polymorphic marker is selected from the group consisting of rs3184504, rs653178, and markers in linkage disequilibrium therewith, and assessing probability of response from to the therapeutic agent from the identity of the at least one allele of the at least one marker.

24. A kit for assessing susceptibility to myocardial infarction of a human individual, the kit comprising reagents for selectively detecting at least one allele of at least one polymorphic marker in the genome of the human individual, wherein the polymorphic marker is selected from the group consisting of rs3184504 and rs653178, and markers in linkage disequilibrium therewith, and a collection of data on a computer-readable medium comprising correlation data between the polymorphic markers and susceptibility to myocardial infarction.

25. (canceled)

26. The kit of claim 24 or 25, wherein the kit comprises reagents for selectively detecting no more than 55 alleles in the genome of the individual.

27-28. (canceled)

29. The kit according to claim 24, wherein the reagents include an oligonucleotide probe that hybridizes to a segment of a nucleic acid whose nucleotide sequence is given by any of SEQ ID NOs: 1-681, wherein the segment is 15-500 nucleotides in length.

30. The kit of claim 29, wherein the segment of the nucleic acid to which the probe hybridizes comprises a polymorphic site.

31-35. (canceled)

36. A method of treatment comprising administering an anti-myocardial infarction agent to a human individual that has been tested for (a) the presence of at least one allele of at least one polymorphic marker selected from the group consisting of rs3184504 and rs653178, and markers in linkage disequilibrium therewith, and/or (b) the presence of an amino acid substitution in an amino acid sequence encoded by the at least one marker.

37. The method of claim 36, wherein the at least one allele is the T allele of rs3184504 and/or the G allele of rs653178.

38-39. (canceled)

40. A method of diagnosing myocardial infarction or myocardial infarction risk in a human individual, comprising (A) one or a combination of: (i) considering the history of an illness and the symptoms experienced by the human individual, (ii) physically examining the human individual, (iii) conducting one or a combination of an electrocardiogram, a coronary angiogram, chest radiograph, echocardiogram on the human individual, (iv) testing blood of the human individual for cardiac markers, (v) detecting areas of reduced blood flow in conjunction with physiologic or pharmacologic stress, and (vi) determining the viability of tissue of the myocardium; and (B) obtaining sequence data identifying at least one allele of at least one polymorphic marker selected from the group consisting of rs3184504 and rs653178, and markers in linkage disequilibrium therewith.

41-77. (canceled)

78. A method of genotyping a nucleic acid sample, comprising determining the identity of at least one allele of at least one polymorphic marker in a nucleic acid sample obtained from a human individual at risk for, or diagnosed with, eosinophilia, wherein the marker is selected from the group consisting of rs1050152, rs11066320, rs11679137, rs11778166, rs11950562, rs12411706, rs9954643, rs12619285, rs1265566, rs12998521, rs1370631, rs1412426, rs1420101, rs1467412, rs1559930, rs1805419, rs184941, rs2079103, rs2164850, rs2165427, rs2188962, rs2244012, rs2269426, rs231228, rs2335050, rs233716, rs233722, rs2416257, rs2426358, rs2532072, rs2663041, rs272893, rs273148, rs2897443, rs3184504, rs3939286, rs4143832, rs4629469, rs4773225, rs4851400, rs4851411, rs4857855, rs6439132, rs6503609, rs653178, rs6730424, rs6871536, rs7150454, rs7223150, rs7315519, rs748065, rs7635061, rs927220, rs9494145, and rs992969, and markers in linkage disequilibrium therewith, whereupon the identity of no more than 110 alleles is determined.

79-80. (canceled)

81. A kit for assessing susceptibility to eosinophilia of a human individual, the kit comprising reagents for selectively detecting at least one allele of at least one polymorphic marker in the genome of the human individual, wherein the polymorphic marker is selected from the group consisting of rs1370631, rs4851400, rs4851411, rs12998521, rs1559930, rs6439132, rs2335050, rs11950562, rs272893, rs1050152, rs2188962, rs2244012, rs2897443, rs6871536, rs992969, rs1265566, rs7315519, rs927220, rs1467412, rs12411706, rs233722, rs233716, rs1805419, rs9954643, rs273148, rs3939286, rs1420101, rs11066320, rs4857855, rs9494145, rs2416257, rs2079103, rs2165427, rs3184504, rs2663041, rs1412426, rs11778166, rs4143832, rs653178, rs6730424, rs4629469, rs748065, rs11679137, rs2164850, rs12619285, rs2269426, rs7635061, rs184941, rs2532072, rs6503609, rs4773225, rs2426358, rs231228, rs7223150, and rs7150454, and markers in linkage disequilibrium therewith, and a computer-readable medium comprising a collection of data comprising correlation data between the polymorphic markers and susceptibility to eosinophilia.

82. (canceled)

83. The kit of claim 81, wherein the kit comprises reagents for selectively detecting no more than 55 alleles in the genome of the individual.

84-85. (canceled)

86. The kit according to claim 81 that comprises an oligonucleotide probe that hybridizes to a segment of a nucleic acid whose nucleotide sequence is given by any of SEQ ID NOs: 1-681, wherein the segment is 15-500 nucleotides in length.

87. The kit claim 86, wherein the segment of the nucleic acid to which the probe hybridizes comprises a polymorphic site.

88-93. (canceled)

94. A method of treatment comprising administering an anti-eosinophilia agent to a human individual that has been tested for (a) the presence of at least one allele of at least one polymorphic marker selected from the group consisting of rs1050152, rs11066320, rs11679137, rs11778166, rs11950562, rs12411706, rs9954643, rs12619285, rs1265566, rs12998521, rs1370631, rs1412426, rs1420101, rs1467412, rs1559930, rs1805419, rs184941, rs2079103, rs2164850, rs2165427, rs2188962, rs2244012, rs2269426, rs231228, rs2335050, rs233716, rs233722, rs2416257, rs2426358, rs2532072, rs2663041, rs272893, rs273148, rs2897443, rs3184504, rs3939286, rs4143832, rs4629469, rs4773225, rs4851400, rs4851411, rs4857855, rs6439132, rs6503609, rs653178, rs6730424, rs6871536, rs7150454, rs7223150, rs7315519, rs748065, rs7635061, rs927220, rs9494145, and rs992969, and markers in linkage disequilibrium therewith; and/or (b) the presence of an amino acid substitution in an amino acid sequence encoded by a marker of the group.

95. The use of claim 94, wherein the at least one allele is selected from the group consisting of wherein the at least one allele is selected from the group consisting of the C allele of rs1050152, the A allele of rs11066320, the G allele of rs11679137, the C allele of rs11778166, the A allele of rs11950562, the G allele of rs12411706, the G allele of rs9954643, the A allele of rs12619285, the T allele of rs1265566, the T allele of rs12998521, the A allele of rs1370631, the T allele of rs1412426, the A allele of rs1420101, the A allele of rs1467412, the A allele of rs1559930, the G allele of rs1805419, the G allele of rs184941, the T allele of rs2079103, the C allele of rs2164850, the A allele of rs2165427, the C allele of rs2188962, the C allele of rs2244012, the T allele of rs2269426, the C allele of rs231228, the C allele of rs2335050, the G allele of rs233716, the C allele of rs233722, the G allele of rs2416257, the C allele of rs2426358, the C allele of rs2532072, the T allele of rs2663041, the A allele of rs272893, the G allele of rs273148, the A allele of rs2897443, the T allele of rs3184504, the A allele of rs3939286, the A allele of rs4143832, the G allele of rs4629469, the G allele of rs4773225, the A allele of rs4851400, the T allele of rs4851411, the C allele of rs4857855, the T allele of rs6439132, the A allele of rs6503609, the G allele of rs653178, the T allele of rs6730424, the C allele of rs6871536, the G allele of rs7150454, the G allele of rs7223150, the A allele of rs7315519, the A allele of rs748065, the A allele of rs7635061, the C allele of rs927220, the T allele of rs9494145, and the A allele of rs992969.

96-124. (canceled)

125. A kit for assessing susceptibility to asthma of a human individual, the kit comprising reagents for selectively detecting at least one allele of at least one polymorphic marker in the genome of the human individual, wherein the polymorphic marker is selected from the group consisting of rs1420101, rs3939286, rs2416257, and rs9494145, and markers in linkage disequilibrium therewith, and a computer-readable medium comprising collection of data comprising correlation data between the polymorphic markers and susceptibility to asthma, wherein the kit comprises reagents for selectively detecting no more than 55 alleles in the genome of the individual.

126-129. (canceled)

130. The kit of claim 125 that comprises an oligonucleotide probe that hybridizes to a segment of a nucleic acid whose nucleotide sequence is given by any of SEQ ID NOs: 1-681, wherein the segment is 15-500 nucleotides in length.

131. The kit of claim 130, wherein the segment of the nucleic acid to which the probe hybridizes comprises a polymorphic site.

132-137. (canceled)

138. A method of treatment that comprises administering an anti-asthma agent to a human individual that has been tested for (a) the presence of at least one allele of at least one polymorphic marker selected from the group consisting of rs1420101, rs3939286, rs2416257, and rs9494145, and markers in linkage disequilibrium therewith; and/or (b) the presence of an amino acid substitution in an amino acid sequence encoded by the at least one marker.

139. The method of claim 138, wherein the at least one allele is selected from the group consisting of the at least one allele is the A allele of rs1420101, the A allele of rs3939286, the G allele of rs2416257, and/or the T allele of rs9494145.

140-143. (canceled)

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