Patent application title: GENE METHYLATION IN CANCER DIAGNOSIS
Inventors:
Jared Ordway (St. Louis, MO, US)
Jared Ordway (St. Louis, MO, US)
Jeffrey A. Jeddeloh (Oakville, MO, US)
Joseph Bedell (Chesterfield, MO, US)
Assignees:
Orion Genomics LLC
IPC8 Class: AC12Q168FI
USPC Class:
435 611
Class name: Measuring or testing process involving enzymes or micro-organisms; composition or test strip therefore; processes of forming such composition or test strip involving nucleic acid nucleic acid based assay involving a hybridization step with a nucleic acid probe, involving a single nucleotide polymorphism (snp), involving pharmacogenetics, involving genotyping, involving haplotyping, or involving detection of dna methylation gene expression
Publication date: 2012-04-26
Patent application number: 20120100541
Abstract:
The present invention provides DNA biomarker sequences that are
differentially methylated in samples from normal individuals and
individuals with cancer. The invention further provides methods of
identifying differentially methylated DNA biomarker sequences and their
use in detecting and diagnosing cancer.Claims:
1. A method for determining the methylation status of an individual, the
method comprising: obtaining a biological sample from an individual; and
determining the methylation status of at least one cytosine within a DNA
region in a sample from the individual where the DNA region is at least
90% identical to a sequence selected from the group consisting of SEQ ID
NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225,
226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239,
240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253,
254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265.
2. The method of claim 1, wherein the determining step comprises determining the methylation status of at least one cytosine in the DNA region corresponding to a nucleotide in a biomarker in the DNA region, wherein the biomarker is a sequence selected from the group consisting of SEQ ID NOs:160, 161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, and 212.
3. The method of claim 2, wherein the determining step comprises determining the methylation status of the DNA region corresponding to the biomarker.
4. The method of claim 1, wherein the sample is from blood serum, blood plasma, fine needle aspirate of the breast, biopsy of the breast, ductal fluid, or ductal lavage.
5. The method of claim 1, wherein the methylation status of at least one cytosine is compared to the methylation status of a control locus.
6. The method of claim 5, wherein the control locus is an endogenous control.
7. The method of claim 5, wherein the control locus is an exogenous control.
8. The method of claim 1, wherein the determining step comprises determining the methylation status of at least one cytosine in at least two DNA regions selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265.
9. A method for determining the presence or absence of cancer in an individual, the method comprising: a) determining the methylation status of at least one cytosine within a DNA region in a sample from an individual where the DNA region is at least 90% identical to a sequence selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265; b) comparing the methylation status of the at least one cytosine to a threshold value for the at least one cytosine, wherein the threshold value distinguishes between individuals with and without cancer, wherein the comparison of the methylation status to the threshold value is predictive of the presence or absence of cancer in the individual.
10. The method of claim 9, wherein DNA region is a sequence selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265.
11. The method of claim 9, wherein the determining step comprises determining the methylation status of at least one cytosine in the DNA region corresponding to a nucleotide in a biomarker, wherein the biomarker is at least 90% identical to a sequence selected from the group consisting of SEQ ID NOs: 160, 161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, and 212.
12. The method of claim 11, wherein the determining step comprises determining the methylation status of the DNA region corresponding to the biomarker.
13. The method of claim 9, wherein the sample is from blood serum, blood plasma, fine needle aspirate of the breast, biopsy of the breast, ductal fluid, or ductal lavage.
14. The method of claim 9, wherein the methylation status of at least one biomarker from the list is compared to the methylation value of a control locus.
15. The method of claim 14, wherein the control locus is an endogenous control.
16. The method of claim 14, wherein the control locus is an exogenous control.
17. The method of claim 9, wherein the determining step comprises determining the methylation status of at least one cytosine from at least two DNA regions.
18. A computer-implemented method for determining the presence or absence of cancer in an individual, the method comprising: receiving, at a host computer, a methylation value representing the methylation status of at least one cytosine within a DNA region in a sample from the individual where the DNA region is at least 90% identical to a sequence selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265; and comparing, in the host computer, the methylation value to a threshold value, wherein the threshold value distinguishes between individuals with and without cancer, wherein the comparison of the methylation value to the threshold value is predictive of the presence or absence of cancer in the individual.
19. The method of claim 18, wherein the receiving step comprises receiving at least two methylation values, the two methylation values representing the methylation status of at least one cytosine biomarkers from two different DNA regions; and the comparing step comprises comparing the methylation values to one or more threshold value(s) wherein the threshold value distinguishes between individuals with and without cancer, wherein the comparison of the methylation value to the threshold value is predictive of the presence or absence of cancer in the individual.
Description:
CROSS-REFERENCE TO RELATED PATENT APPLICATIONS
[0001] The present application is a continuation of U.S. patent application Ser. No. 11/809,355, filed May 30, 2007, and claims benefit of priority to U.S. Provisional Patent application No. 60/803,571, filed May 31, 2006, and U.S. Provisional Patent application No. 60/848,543, filed Sep. 28, 2006, each of which are incorporated by reference in their entirety.
BACKGROUND OF THE INVENTION
[0002] Human cancer cells typically contain somatically altered genomes, characterized by mutation, amplification, or deletion of critical genes. In addition, the DNA template from human cancer cells often displays somatic changes in DNA methylation. See, e.g., E. R. Fearon, et al, Cell 61:759 (1990); P. A. Jones, et al., Cancer Res. 46:461 (1986); R. Holliday, Science 238:163 (1987); A. De Bustros, et al., Proc. Natl. Acad. Sci. USA 85:5693 (1988); P. A. Jones, et al., Adv. Cancer Res. 54:1 (1990); S. B. Baylin, et al., Cancer Cells 3:383 (1991); M. Makos, et al., Proc. Natl. Acad. Sci. USA 89:1929 (1992); N. Ohtani-Fujita, et al., Oncogene 8:1063 (1993).
[0003] DNA methylases transfer methyl groups from the universal methyl donor S-adenosyl methionine to specific sites on the DNA. Several biological functions have been attributed to the methylated bases in DNA. The most established biological function is the protection of the DNA from digestion by cognate restriction enzymes. This restriction modification phenomenon has, so far, been observed only in bacteria.
[0004] Mammalian cells, however, possess different methylases that exclusively methylate cytosine residues on the DNA that are 5' neighbors of guanine (CpG). This methylation has been shown by several lines of evidence to play a role in gene activity, cell differentiation, tumorigenesis, X-chromosome inactivation, genomic imprinting and other major biological processes (Razin, A., H., and Riggs, R. D. eds. in DNA Methylation Biochemistry and Biological Significance, Springer-Verlag, N.Y., 1984).
[0005] In eukaryotic cells, methylation of cytosine residues that are immediately 5' to a guanosine, occurs predominantly in CG poor loci (Bird, A., Nature 321:209 (1986)). In contrast, discrete regions of CG dinucleotides called CG islands (CGi) remain unmethylated in normal cells, except during X-chromosome inactivation and parental specific imprinting (Li, et al., Nature 366:362 (1993)) where methylation of 5' regulatory regions can lead to transcriptional repression. For example, de novo methylation of the Rb gene has been demonstrated in a small fraction of retinoblastomas (Sakai, et al., Am. J. Hum. Genet., 48:880 (1991)), and a more detailed analysis of the VHL gene showed aberrant methylation in a subset of sporadic renal cell carcinomas (Herman, et al., Proc. Natl. Acad. Sci. U.S.A., 91:9700 (1994)). Expression of a tumor suppressor gene can also be abolished by de novo DNA methylation of a normally unmethylated 5' CG island. See, e.g., Issa, et al., Nature Genet. 7:536 (1994); Merlo, et al., Nature Med. 1:686 (1995); Herman, et al., Cancer Res., 56:722 (1996); Graff, et al., Cancer Res., 55:5195 (1995); Herman, et al., Cancer Res. 55:4525 (1995).
[0006] Identification of the earliest genetic and epigenetic changes in tumorigenesis is a major focus in molecular cancer research. Diagnostic approaches based on identification of these changes can allow implementation of early detection strategies, tumor staging and novel therapeutic approaches targeting these early changes, leading to more effective cancer treatment. The present invention addresses these and other problems.
BRIEF SUMMARY OF THE INVENTION
[0007] The present invention provides methods for determining the methylation status of an individual. In one aspect, the methods comprise: [0008] obtaining a biological sample from an individual; and [0009] determining the methylation status of at least one cytosine within a DNA region in a sample from the individual where the DNA region is a SEQ ID NO: selected from the group consisting of 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265.
[0010] In a further aspect, the methods comprise determining the presence or absence of cancer (including but not limited to breast, lung, renal, liver, ovarian, head and neck, thyroid, bladder, cervical, colon, endometrial, esophageal, or prostate cancer or melanoma) in an individual.
[0011] In some embodiments, the methods comprise: [0012] a) determining the methylation status of at least one cytosine within a DNA region in a sample from an individual where the DNA region is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to, or comprises, a sequence selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265; [0013] b) comparing the methylation status of the at least one cytosine to a threshold value for the biomarker, wherein the threshold value distinguishes between individuals with and without cancer, wherein the comparison of the methylation status to the threshold value is predictive of the presence or absence of cancer in the individual.
[0014] In some embodiments, the methods comprise: [0015] a) determining the methylation status of at least one cytosine within a DNA region in a sample from an individual where the DNA region is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to, or comprises, a sequence selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265; [0016] b) comparing the methylation status of the at least one cytosine to a threshold value for the biomarker, wherein the threshold value distinguishes between individuals with and without breast cancer, wherein the comparison of the methylation status to the threshold value is predictive of the presence or absence of breast cancer in the individual.
[0017] In some embodiments, the methods comprise: [0018] a) determining the methylation status of at least one cytosine within a DNA region in a sample from an individual where the DNA region is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to, or comprises, a sequence selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265; [0019] b) comparing the methylation status of the at least one cytosine to a threshold value for the biomarker, wherein the threshold value distinguishes between individuals with and without lung cancer, wherein the comparison of the methylation status to the threshold value is predictive of the presence or absence of lung cancer in the individual.
[0020] In some embodiments, the methods comprise: [0021] a) determining the methylation status of at least one cytosine within a DNA region in a sample from an individual where the DNA region is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to, or comprises, a sequence selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265; [0022] b) comparing the methylation status of the at least one cytosine to a threshold value for the biomarker, wherein the threshold value distinguishes between individuals with and without renal cancer, wherein the comparison of the methylation status to the threshold value is predictive of the presence or absence of renal cancer in the individual.
[0023] In some embodiments, the methods comprise: [0024] a) determining the methylation status of at least one cytosine within a DNA region in a sample from an individual where the DNA region is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to, or comprises, a sequence selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265; [0025] b) comparing the methylation status of the at least one cytosine to a threshold value for the biomarker, wherein the threshold value distinguishes between individuals with and without liver cancer, wherein the comparison of the methylation status to the threshold value is predictive of the presence or absence of liver cancer in the individual.
[0026] In some embodiments, the methods comprise: [0027] a) determining the methylation status of at least one cytosine within a DNA region in a sample from an individual where the DNA region is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to, or comprises, a sequence selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265; [0028] b) comparing the methylation status of the at least one cytosine to a threshold value for the biomarker, wherein the threshold value distinguishes between individuals with and without ovarian cancer, wherein the comparison of the methylation status to the threshold value is predictive of the presence or absence of ovarian cancer in the individual.
[0029] In some embodiments, the methods comprise: [0030] a) determining the methylation status of at least one cytosine within a DNA region in a sample from an individual where the DNA region is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to, or comprises, a sequence selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265; [0031] b) comparing the methylation status of the at least one cytosine to a threshold value for the biomarker, wherein the threshold value distinguishes between individuals with and without head and neck cancer, wherein the comparison of the methylation status to the threshold value is predictive of the presence or absence of head and neck cancer in the individual.
[0032] In some embodiments, the methods comprise: [0033] a) determining the methylation status of at least one cytosine within a DNA region in a sample from an individual where the DNA region is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to, or comprises, a sequence selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265; [0034] b) comparing the methylation status of the at least one cytosine to a threshold value for the biomarker, wherein the threshold value distinguishes between individuals with and without thyroid cancer, wherein the comparison of the methylation status to the threshold value is predictive of the presence or absence of thyroid cancer in the individual.
[0035] In some embodiments, the methods comprise: [0036] a) determining the methylation status of at least one cytosine within a DNA region in a sample from an individual where the DNA region is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to, or comprises, a sequence selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265; [0037] b) comparing the methylation status of the at least one cytosine to a threshold value for the biomarker, wherein the threshold value distinguishes between individuals with and without bladder cancer, wherein the comparison of the methylation status to the threshold value is predictive of the presence or absence of bladder cancer in the individual.
[0038] In some embodiments, the methods comprise: [0039] a) determining the methylation status of at least one cytosine within a DNA region in a sample from an individual where the DNA region is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to, or comprises, a sequence selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265; [0040] b) comparing the methylation status of the at least one cytosine to a threshold value for the biomarker, wherein the threshold value distinguishes between individuals with and without cervical cancer, wherein the comparison of the methylation status to the threshold value is predictive of the presence or absence of cervical cancer in the individual.
[0041] In some embodiments, the methods comprise: [0042] a) determining the methylation status of at least one cytosine within a DNA region in a sample from an individual where the DNA region is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to, or comprises, a sequence selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265; [0043] b) comparing the methylation status of the at least one cytosine to a threshold value for the biomarker, wherein the threshold value distinguishes between individuals with and without colon cancer, wherein the comparison of the methylation status to the threshold value is predictive of the presence or absence of colon cancer in the individual.
[0044] In some embodiments, the methods comprise: [0045] a) determining the methylation status of at least one cytosine within a DNA region in a sample from an individual where the DNA region is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to, or comprises, a sequence selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265; [0046] b) comparing the methylation status of the at least one cytosine to a threshold value for the biomarker, wherein the threshold value distinguishes between individuals with and without endometrial cancer, wherein the comparison of the methylation status to the threshold value is predictive of the presence or absence of endometrial cancer in the individual.
[0047] In some embodiments, the methods comprise: [0048] a) determining the methylation status of at least one cytosine within a DNA region in a sample from an individual where the DNA region is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to, or comprises, a sequence selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265; [0049] b) comparing the methylation status of the at least one cytosine to a threshold value for the biomarker, wherein the threshold value distinguishes between individuals with and without esophageal cancer, wherein the comparison of the methylation status to the threshold value is predictive of the presence or absence of esophegeal cancer in the individual.
[0050] In some embodiments, the methods comprise: [0051] a) determining the methylation status of at least one cytosine within a DNA region in a sample from an individual where the DNA region is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to, or comprises, a sequence selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265; [0052] b) comparing the methylation status of the at least one cytosine to a threshold value for the biomarker, wherein the threshold value distinguishes between individuals with and without colon cancer, wherein the comparison of the methylation status to the threshold value is predictive of the presence or absence of colon cancer in the individual.
[0053] In some embodiments, the methods comprise: [0054] a) determining the methylation status of at least one cytosine within a DNA region in a sample from an individual where the DNA region is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to, or comprises, a sequence selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265; [0055] b) comparing the methylation status of the at least one cytosine to a threshold value for the biomarker, wherein the threshold value distinguishes between individuals with and without prostate cancer, wherein the comparison of the methylation status to the threshold value is predictive of the presence or absence of prostate cancer in the individual.
[0056] In some embodiments, the methods comprise: [0057] a) determining the methylation status of at least one cytosine within a DNA region in a sample from an individual where the DNA region is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to, or comprises, a sequence selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265; [0058] b) comparing the methylation status of the at least one cytosine to a threshold value for the biomarker, wherein the threshold value distinguishes between individuals with and without melanoma, wherein the comparison of the methylation status to the threshold value is predictive of the presence or absence of melanoma in the individual.
[0059] With regard to the embodiments, in some embodiments, the determining step comprises determining the methylation status of at least one cytosine in the DNA region corresponding to a nucleotide in a biomarker in the DNA region, wherein the biomarker is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to, or comprises, a sequence selected from the group consisting of SEQ ID NOs:160, 161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, and 212.
[0060] In some embodiments, the determining step comprises determining the methylation status of the DNA region corresponding to a biomarker.
[0061] In some embodiments, the sample is from any body fluid, including but not limited to blood serum, blood plasma, fine needle aspirate of the breast, biopsy of the breast, ductal fluid, ductal lavage, feces, urine, sputum, saliva, semen, lavages, biopsy of the lung, bronchial lavage or bronchial brushings. In some embodiments, the sample is from a tumor or polyp. In some embodiments, the sample is a biopsy from lung, kidney, liver, ovarian, head, neck, thyroid, bladder, cervical, colon, endometrial, esophageal, prostate or skin tissue. In some embodiments, the sample is from cell scrapes, washings, or resected tissues.
[0062] In some embodiments, the methylation status of at least one cytosine is compared to the methylation status of a control locus. In some embodiments, the control locus is an endogenous control. In some embodiments, the control locus is an exogenous control.
[0063] In some embodiments, the determining step comprises determining the methylation status of at least one cytosine in at least two of the DNA regions.
[0064] In a further aspect, the invention provides computer implemented methods for determining the presence or absence of cancer (including but not limited to breast, lung, renal, liver, ovarian, head and neck, thyroid, bladder, cervical, colon, endometrial, esophageal, prostate or melanoma) in an individual. In some embodiments, the methods comprise: [0065] receiving, at a host computer, a methylation value representing the methylation status of at least one cytosine within a DNA region in a sample from the individual where the DNA region is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to, or comprises, a sequence selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265; and [0066] comparing, in the host computer, the methylation value to a threshold value, wherein the threshold value distinguishes between individuals with and without cancer (including but not limited to breast, lung, renal, liver, ovarian, head and neck, thyroid, bladder, cervical, colon, endometrial, esophageal, prostate or melanoma), wherein the comparison of the methylation value to the threshold value is predictive of the presence or absence of cancer (including but not limited to breast, lung, renal, liver, ovarian, head and neck, thyroid, bladder, cervical, colon, endometrial, esophageal, or prostate cancer or melanoma) in the individual.
[0067] In some embodiments, the receiving step comprises receiving at least two methylation values, the two methylation values representing the methylation status of at least one cytosine biomarkers from two different DNA regions; and [0068] the comparing step comprises comparing the methylation values to one or more threshold value(s) wherein the threshold value distinguishes between individuals with and without cancer (including but not limited to breast, lung, renal, liver, ovarian, head and neck, thyroid, bladder, cervical, colon, endometrial, esophageal, prostate or melanoma), wherein the comparison of the methylation value to the threshold value is predictive of the presence or absence of cancer (including but not limited to breast, lung, renal, liver, ovarian, head and neck, thyroid, bladder, cervical, colon, endometrial, esophageal, or prostate cancer or melanoma) in the individual.
[0069] In another aspect, the invention provides computer program products for determining the presence or absence of cancer (including but not limited to breast, lung, renal, liver, ovarian, head and neck, thyroid, bladder, cervical, colon, endometrial, esophageal, or prostate cancer or melanoma) in an individual. In some embodiments, the computer readable products comprise: [0070] a computer readable medium encoded with program code, the program code including: [0071] program code for receiving a methylation value representing the methylation status of at least one cytosine within a DNA region in a sample from the individual where the DNA region is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to, or comprises, a sequence selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265; and [0072] program code for comparing the methylation value to a threshold value, wherein the threshold value distinguishes between individuals with and without cancer (including but not limited to breast, lung, renal, liver, ovarian, head and neck, thyroid, bladder, cervical, colon, endometrial, esophageal, or prostate cancer or melanoma), wherein the comparison of the methylation value to the threshold value is predictive of the presence or absence of cancer (including but not limited to breast, lung, renal, liver, ovarian, head and neck, thyroid, bladder, cervical, colon, endometrial, esophageal, or prostate cancer or melanoma) in the individual.
[0073] In a further aspect, the invention provides kits for determining the methylation status of at least one biomarker. In some embodiments, the kits comprise: [0074] a pair of polynucleotides capable of specifically amplifying at least a portion of a DNA region where the DNA region is a sequence selected from the group consisting of SEQ ID NOs: of 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265; and [0075] a methylation-dependent or methylation sensitive restriction enzyme and/or sodium bisulfite.
[0076] In some embodiments, the pair of polynucleotides are capable of specifically amplifying a biomarker selected from the group consisting of one or more of SEQ ID NOs: 160, 161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, and 212.
[0077] In some embodiments, the kits comprise at least two pairs of polynucleotides, wherein each pair is capable of specifically amplifying at least a portion of a different DNA region selected from the group consisting of SEQ ID NOs: of 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265.
[0078] In some embodiments, the kits further comprise a detectably labeled polynucleotide probe that specifically detects the amplified biomarker in a real time amplification reaction.
[0079] In a further aspect, the invention provides kits for determining the methylation status of at least one biomarker. In some embodiments, the kits comprise: [0080] sodium bisulfite and polynucleotides to quantify the presence of the converted methylated and or the converted unmethylated sequence of at least one cytosine from a DNA region that is selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265.
[0081] In a further aspect, the invention provides kits for determining the methylation status of at least one biomarker. In some embodiments, the kits comprise: [0082] sodium bisulfite, primers and adapters for whole genome amplification, and polynucleotides to quantify the presence of the converted methylated and or the converted unmethylated sequence of at least one cytosine from a DNA region that is selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265.
[0083] In another aspect, the methods provide kits for determining the methylation status of at least one biomarker. In some embodiments, the kits comprise: [0084] a methylation sensing restriction enzymes, primers and adapters for whole genome amplification, and polynucleotides to quantify the number of copies of at least a portion of a DNA region where the DNA region is selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265.
[0085] In a further aspect, the invention provides kits for determining the methylation status of at least one biomarker. In some embodiments, the kits comprise: [0086] a methylation binding moiety and one or more polynucleotides to quantify the number of copies of at least a portion of a DNA region where the DNA region is selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265.
DEFINITIONS
[0087] "Methylation" refers to cytosine methylation at positions C5 or N4 of cytosine, the N6 position of adenine or other types of nucleic acid methylation. In vitro amplified DNA is unmethylated because in vitro DNA amplification methods do not retain the methylation pattern of the amplification template. However, "unmethylated DNA" or "methylated DNA" can also refer to amplified DNA whose original template was methylated or methylated, respectively.
[0088] A "methylation profile" refers to a set of data representing the methylation states of one or more loci within a molecule of DNA from e.g., the genome of an individual or cells or tissues from an individual. The profile can indicate the methylation state of every base in an individual, can comprise information regarding a subset of the base pairs (e.g., the methylation state of specific restriction enzyme recognition sequence) in a genome, or can comprise information regarding regional methylation density of each locus.
[0089] "Methylation status" refers to the presence, absence and/or quantity of methylation at a particular nucleotide, or nucleotides within a portion of DNA. The methylation status of a particular DNA sequence (e.g., a DNA biomarker or DNA region as described herein) can indicate the methylation state of every base in the sequence or can indicate the methylation state of a subset of the base pairs (e.g., of cytosines or the methylation state of one or more specific restriction enzyme recognition sequences) within the sequence, or can indicate information regarding regional methylation density within the sequence without providing precise information of where in the sequence the methylation occurs. The methylation status can optionally be represented or indicated by a "methylation value." A methylation value can be generated, for example, by quantifying the amount of intact DNA present following restriction digestion with a methylation dependent restriction enzyme. In this example, if a particular sequence in the DNA is quantified using quantitative PCR, an amount of template DNA approximately equal to a mock treated control indicates the sequence is not highly methylated whereas an amount of template substantially less than occurs in the mock treated sample indicates the presence of methylated DNA at the sequence. Accordingly, a value, i.e., a methylation value, for example from the above described example, represents the methylation status and can thus be used as a quantitative indicator of methylation status. This is of particular use when it is desirable to compare the methylation status of a sequence in a sample to a threshold value.
[0090] A "methylation-dependent restriction enzyme" refers to a restriction enzyme that cleaves or digests DNA at or in proximity to a methylated recognition sequence, but does not cleave DNA at or near the same sequence when the recognition sequence is not methylated. Methylation-dependent restriction enzymes include those that cut at a methylated recognition sequence (e.g., DpnI) and enzymes that cut at a sequence near but not at the recognition sequence (e.g., McrBC). For example, McrBC's recognition sequence is 5' RmC (N40-3000) RmC 3' where "R" is a purine and "mC" is a methylated cytosine and "N40-3000" indicates the distance between the two RmC half sites for which a restriction event has been observed. McrBC generally cuts close to one half-site or the other, but cleavage positions are typically distributed over several base pairs, approximately 30 base pairs from the methylated base. McrBC sometimes cuts 3' of both half sites, sometimes 5' of both half sites, and sometimes between the two sites. Exemplary methylation-dependent restriction enzymes include, e.g., McrBC (see, e.g., U.S. Pat. No. 5,405,760), McrA, MrrA, and DpnI. One of skill in the art will appreciate that any methylation-dependent restriction enzyme, including homologs and orthologs of the restriction enzymes described herein, is also suitable for use in the present invention.
[0091] A "methylation-sensitive restriction enzyme" refers to a restriction enzyme that cleaves DNA at or in proximity to an unmethylated recognition sequence but does not cleave at or in proximity to the same sequence when the recognition sequence is methylated. Exemplary methylation-sensitive restriction enzymes are described in, e.g., McClelland et al., Nucleic Acids Res. 22(17):3640-59 (1994) and http://rebase.neb.com. Suitable methylation-sensitive restriction enzymes that do not cleave DNA at or near their recognition sequence when a cytosine within the recognition sequence is methylated at position C5 include, e.g., Aat II, Aci I, Acl I, Age I, Alu I, Asc I, Ase I, AsiS I, Bbe I, BsaA I, BsaH I, BsiE I, BsiW I, BsrF I, BssH II, BssK I, BstB I, BstN I, BstU I, Cla I, Eae I, Eag I, Fau I, Fse I, Hha I, HinP1 I, HinC II, Hpa II, Hpy99 I, HpyCH4 IV, Kas I, Mbo I, Mlu I, MapAl I, Msp I, Nae I, Nar I, Not I, Pml I, Pst I, Pvu I, Rsr II, Sac II, Sap I, Sau3A I, Sfl I, Sfo I, SgrA I, Sma I, SnaB I, Tsc I, Xma I, and Zra I. Suitable methylation-sensitive restriction enzymes that do not cleave DNA at or near their recognition sequence when an adenosine within the recognition sequence is methylated at position N6 include, e.g., Mbo I. One of skill in the art will appreciate that any methylation-sensitive restriction enzyme, including homologs and orthologs of the restriction enzymes described herein, is also suitable for use in the present invention. One of skill in the art will further appreciate that a methylation-sensitive restriction enzyme that fails to cut in the presence of methylation of a cytosine at or near its recognition sequence may be insensitive to the presence of methylation of an adenosine at or near its recognition sequence. Likewise, a methylation-sensitive restriction enzyme that fails to cut in the presence of methylation of an adenosine at or near its recognition sequence may be insensitive to the presence of methylation of a cytosine at or near its recognition sequence. For example, Sau3AI is sensitive (i.e., fails to cut) to the presence of a methylated cytosine at or near its recognition sequence, but is insensitive (i.e., cuts) to the presence of a methylated adenosine at or near its recognition sequence. One of skill in the art will also appreciate that some methylation-sensitive restriction enzymes are blocked by methylation of bases on one or both strands of DNA encompassing of their recognition sequence, while other methylation-sensitive restriction enzymes are blocked only by methylation on both strands, but can cut if a recognition site is hemi-methylated.
[0092] A "threshold value that distinguishes between individuals with and without" a particular disease refers to a value or range of values of a particular measurement that can be used to distinguish between samples from individuals with the disease and samples without the disease. Ideally, there is a threshold value or values that absolutely distinguishes between the two groups (i.e., values from the diseased group are always on one side (e.g., higher) of the threshold value and values from the healthy, nog-diseased group are on the other side (e.g., lower) of the threshold value). However, in many instances, threshold values do not absolutely distinguish between diseased and non-diseased samples (for example, when there is some overlap of values generated from diseased and non-diseased samples).
[0093] The phrase "corresponding to a nucleotide in a biomarker" refers to a nucleotide in a DNA region that aligns with the same nucleotide (e.g., a cytosine) in a biomarker sequence. Generally, as described herein, biomarker sequences are subsequences of the DNA regions. Sequence comparisons can be performed using any BLAST including BLAST 2.2 algorithm with default parameters, described in Altschul et al., Nuc. Acids Res. 25:3389 3402 (1997) and Altschul et al., J. Mol. Biol. 215:403 410 (1990), respectively. Thus for example, a DNA region or biomarker described herein can correspond to a DNA sequence in a human genome even if there is slight variation between the biomarker or DNA region and the particular human genome in question. Such difference can be the result of slight genetic variation between humans.
[0094] "Sensitivity" of a given biomarker refers to the percentage of tumor samples that report a DNA methylation value above a threshold value that distinguishes between tumor and non-tumor samples. The percentage is calculated as follows:
Sensitivity = [ ( the number of tumor samples above the threshold ) ( the total number of tumor samples tested ) ] × 100 ##EQU00001##
The equation may also be stated as follows:
Sensitivity = [ ( the number of true positive samples ) ( the number of true positive samples ) + ( the number of false negative samples ) ] × 100 ##EQU00002##
where true positive is defined as a histology-confirmed tumor sample that reports a DNA methylation value above the threshold value (i.e. the range associated with disease), and false negative is defined as a histology-confirmed tumor sample that reports a DNA methylation value below the threshold value (i.e. the range associated with no disease). The value of sensitivity, therefore, reflects the probability that a DNA methylation measurement for a given biomarker obtained from a known diseased sample will be in the range of disease-associated measurements. As defined here, the clinical relevance of the calculated sensitivity value represents an estimation of the probability that a given biomarker would detect the presence of a clinical condition when applied to a patient with that condition.
[0095] "Specificity" of a given biomarker refers to the percentage of non-tumor samples that report a DNA methylation value below a threshold value that distinguishes between tumor and non-tumor samples. The percentage is calculated as follows:
Specificity = [ ( the number of non - tumor samples below the threshold ) ( the total number of non - tumor samples tested ) ] × 100 ##EQU00003##
The equation may also be stated as follows:
Specificity = [ ( the number of true negative samples ) ( the number of true negative samples ) + ( the number of false positive samples ) ] × 100 ##EQU00004##
where true negative is defined as a histology-confirmed non-tumor sample that reports a DNA methylation value below the threshold value (i.e. the range associated with no disease), and false positive is defined as a histology-confirmed non-tumor sample that reports DNA methylation value above the threshold value (i.e. the range associated with disease). The value of specificity, therefore, reflects the probability that a DNA methylation measurement for a given biomarker obtained from a known non-diseased sample will be in the range of non-disease associated measurements. As defined here, the clinical relevance of the calculated specificity value represents an estimation of the probability that a given biomarker would detect the absence of a clinical condition when applied to a patient without that condition.
[0096] Software for performing BLAST analyses is publicly available through the National Center for Biotechnology Information. This algorithm involves first identifying high scoring sequence pairs (HSPs) by identifying short words of length W in the query sequence, which either match or satisfy some positive-valued threshold score T when aligned with a word of the same length in a database sequence. T is referred to as the neighborhood word score threshold (Altschul et al., supra). These initial neighborhood word hits act as seeds for initiating searches to find longer HSPs containing them. The word hits are extended in both directions along each sequence for as far as the cumulative alignment score can be increased. Cumulative scores are calculated using, for nucleotide sequences, the parameters M (reward score for a pair of matching residues; always >0) and N (penalty score for mismatching residues; always <0). For amino acid sequences, a scoring matrix is used to calculate the cumulative score. Extension of the word hits in each direction are halted when: the cumulative alignment score falls off by the quantity X from its maximum achieved value; the cumulative score goes to zero or below, due to the accumulation of one or more negative-scoring residue alignments; or the end of either sequence is reached. The BLAST algorithm parameters W, T, and X determine the sensitivity and speed of the alignment. The BLASTN program (for nucleotide sequences) uses as defaults a wordlength (W) of 11, an expectation (E) of 10, M=5, N=-4 and a comparison of both strands. For amino acid sequences, the BLASTP program uses as defaults a wordlength of 3, and expectation (E) of 10, and the BLOSUM62 scoring matrix (see Henikoff & Henikoff, Proc. Natl. Acad. Sci. USA 89:10915 (1989)) alignments (B) of 50, expectation (E) of 10, M=5, N=-4, and a comparison of both strands.
[0097] As used herein, the terms "nucleic acid," "polynucleotide" and "oligonucleotide" refer to nucleic acid regions, nucleic acid segments, primers, probes, amplicons and oligomer fragments. The terms are not limited by length and are generic to linear polymers of polydeoxyribonucleotides (containing 2-deoxy-D-ribose), polyribonucleotides (containing D-ribose), and any other N-glycoside of a purine or pyrimidine base, or modified purine or pyrimidine bases. These terms include double- and single-stranded DNA, as well as double- and single-stranded RNA.
[0098] A nucleic acid, polynucleotide or oligonucleotide can comprise, for example, phosphodiester linkages or modified linkages including, but not limited to phosphotriester, phosphoramidate, siloxane, carbonate, carboxymethylester, acetamidate, carbamate, thioether, bridged phosphoramidate, bridged methylene phosphonate, phosphorothioate, methylphosphonate, phosphorodithioate, bridged phosphorothioate or sulfone linkages, and combinations of such linkages.
[0099] A nucleic acid, polynucleotide or oligonucleotide can comprise the five biologically occurring bases (adenine, guanine, thymine, cytosine and uracil) and/or bases other than the five biologically occurring bases. For example, a polynucleotide of the invention can contain one or more modified, non-standard, or derivatized base moieties, including, but not limited to, N6-methyl-adenine, N6-tert-butyl-benzyl-adenine, imidazole, substituted imidazoles, 5-fluorouracil, 5-bromouraci1,5-chlorouracil, 5-iodouracil, hypoxanthine, xanthine, 4-acetylcytosine, 5-(carboxyhydroxymethyl)uracil, 5-carboxymethylaminomethyl-2-thiouridine, 5-carboxymethylaminomethyluracil, dihydrouracil, beta-D-galactosylqueosine, inosine, N6-isopentenyladenine, 1-methylguanine, 1-methylinosine, 2,2-dimethylguanine, 2-methyladenine, 2-methylguanine, 3-methylcytosine, 5-methylcytosine, N6-methyladenine, 7-methylguanine, 5-methylaminomethyluracil, 5-methoxyaminomethyl-2-thiouracil, beta-D mannosylqueosine, 5'-methoxycarboxymethyluracil, 5-methoxyuracil, 2-methylthio-N6-isopentenyladenine, uracil-5-oxyacetic acid (v), wybutoxosine, pseudouracil, queosine, 2-thiocytosine, 5-methyl-2-thiouracil, 2-thiouracil, 4-thiouracil, uracil-5-oxyacetic acidmethylester, 3-(3-amino-3-N-2-carboxypropyl) uracil, (acp3)w, 2,6-diaminopurine, and 5-propynyl pyrimidine. Other examples of modified, non-standard, or derivatized base moieties may be found in U.S. Pat. Nos. 6,001,611; 5,955,589; 5,844,106; 5,789,562; 5,750,343; 5,728,525; and 5,679,785.
[0100] Furthermore, a nucleic acid, polynucleotide or oligonucleotide can comprise one or more modified sugar moieties including, but not limited to, arabinose, 2-fluoroarabinose, xylulose, and a hexose.
BRIEF DESCRIPTION OF THE DRAWINGS
[0101] FIG. 1 illustrates a general overview of the experimental design of differential methylation screening. A graphical representation of the transcription start site and 5' structure of one predicted differentially methylated gene is indicated (A). The bar graph (B) indicates the relative local density of purine-CG sequences within this region. The relative position of the DNA microarray feature that reported differential DNA methylation at this locus is indicated by (C). PCR primers were selected to amplify the region indicated by (D). The vertical bars (E and F) represent the microarray DNA methylation measurement representing all breast tumors (E) and all normal breast samples (F).
[0102] FIG. 2 illustrates an example of McrBC-based real-time PCR strategy to monitor DNA methylation status. Panel A shows the untreated/treated PCR replicate 1 for amplification of the GHSR locus in a breast tumor sample. The delta Ct (Treated 1--Untreated 1) is 5.38 cycles. Panel B shows the untreated/treated PCR replicate 2 for amplification of the same locus from the same tumor sample. The delta Ct (Treated 2--Untreated 2) is 5.40 cycles. Panel C shows the untreated/treated PCR replicate 1 for amplification of the GHSR locus in a normal breast sample. The delta Ct (Treated 1--Untreated 1) is 0.18 cycles. Panel D shows the untreated/treated PCR replicate 2 for amplification of the same locus from the same normal sample. The delta Ct (Treated 2--Untreated 2) is 0.03 cycles. Tumor samples produce a change in cycle threshold ("delta Ct") of 1.0 or greater. Normal samples produce a delta Ct of less than 1.0.
[0103] FIGS. 3A-B illustrates verification of microarray DNA methylation predictions. Open boxes represent loci that are unmethylated (average delta Ct<1.0), grey boxes represent loci that are methylated (average delta Ct>1 and <2), and black boxes represent loci that are densely methylated (average delta Ct>2).
[0104] FIGS. 4A and 4B illustrate validation of DNA methylation differences in biomarkers from independent tumor and normal samples. Boxes are as indicated for FIG. 3.
[0105] FIG. 5 illustrates DNA methylation differences in biomarkers from a larger panel of breast tumor, normal breast and normal peripheral blood samples. Boxes are as indicated for FIG. 3.
[0106] FIG. 6 illustrates demonstration of threshold adjustment for determining sensitivity and specificity.
[0107] FIG. 7 illustrates bisulfite sequencing confirmation of differential DNA methylation.
[0108] FIG. 8 illustrates the correlation between qPCR based DNA methylation measurements and DNA methylation occupancies determined by bisulfite sequencing. Primers were designed to amplify approximately 150 bp amplicons within the region of three loci that were analyzed by qPCR as described above. The loci included feature ID halp--39189 (locus number 2), ha1g--00644 (locus number 3) and ha1p--104423 (locus number 12). For each amplicon, products were amplified from three normal breast DNA samples that reported average dCt values <0.5, three normal breast DNA samples that reported average dCt values between 0.5 and 1.0, and three breast tumor DNA samples that reported average dCt values greater than 1.0. Amplicons were purified and cloned using TA cloning kits (Invitrogen). At least 29 independent clones were sequenced per amplicon, per locus. The graph shows the median 5-methylcytosine content for all sequenced clones per amplicon plotted against the average dCt value for that locus in the same DNA sample. The dashed vertical line represents the dCt=1.0 threshold used to indicate a positive qPCR measurement for DNA methylation detection.
[0109] FIG. 9 illustrates an example of selection of a potentially differentially methylated region based on an analysis of CpG density (identification of a CG island).
[0110] FIG. 10A illustrates the frequency of differential DNA methylation of 16 loci in stage I breast tumors relative to stage II-III breast tumors. The 16 loci include those listed in Table 5.
[0111] FIG. 10B illustrates the DNA methylation density of three selected loci relative to tumor stage. The averaged approximate percent depletion of methylated molecules by McrBC was calculated to determine the load of methylated molecules in each sample [1-(1/2 delta Ct (McrBC digested--Mock treated))*100]. Data are plotted (from left to right) for normal breast samples, stage I tumors, stage IIA tumors, stage IIB tumors and stage III tumors.
[0112] FIG. 11A illustrates the differential DNA methylation of four selected loci in breast tumor, normal breast tissue and peripheral blood from a cancer-free woman. Each data point represents the averaged delta Ct value for an independent clinical sample.
[0113] FIG. 11B illustrates ROC curve analyses of the four loci depicted in FIG. 11A. Sensitivity (percentage of tumor samples scoring above a methylation threshold) and specificity (percentage of non-tumor samples scoring below that same threshold) were calculated for all observed delta Ct values.
[0114] FIG. 12 illustrates the analysis of DNA methylation of four selected loci by bisulfite sequencing. Analyzed loci included locus number 2 (A, B), 3 (C, D), 4 (E, F) and 12 (G, H). Bisulfite sequencing was performed. The average number of molecules sequenced for each locus within each sample was 587. The calculated DNA methylation density (number of methylated CpGs divided by the total number of CpGs sequenced) for each sample is plotted versus the qPCR DNA methylation measurement for the same sample (A, C, E, G). In addition, the percent methylation occupancy at each analyzed CpG dinucleotide is shown (B, D, F, H). Analyzed samples included normal breast tissues (open circles), adjacent histology normal breast tissues (filled circles) and breast tumors (filled squares).
[0115] FIG. 13 illustrates the correlation between DNA hypermethylation and gene expression. Transcription of GHSR (locus number 2), MGA (locus number 4), and NFX1 (locus number 12) were analyzed by RT-PCR. Serial dilutions of cDNA from normal breast tissue and four breast tumors were used as template as indicated. GAPDH expression was analyzed as an internal control for each sample. The DNA methylation measurement (qPCR) for each locus in each tumor sample is indicated (-average dCt<1.0, +average dCt>1.0 but <2.0, and ++average dCt>2.0).
[0116] FIG. 14 illustrates the comparison of DNA methylation detection in fine needle aspirate (% POSITIVE FNA) samples relative to unmatched primary breast tumor samples (% POSITIVE TUMOR). Each sample was scored as positive if the average dCt was ≧1.0, as described in Example 3. Analyzed samples included 7 FNA samples and at least 14 primary breast tumor samples.
DETAILED DESCRIPTION OF THE INVENTION
I. Introduction
[0117] The present invention is based, in part, on the discovery that sequences in certain DNA regions are methylated in cancer cells, but not normal cells. The inventors have found that methylation within the DNA regions described herein are associated with breast cancer, particularly ductal carcinoma, as well as a number of other cancers.
[0118] In view of this discovery, the inventors have recognized that methods for detecting the biomarker sequences and DNA regions comprising the biomarker sequences as well as sequences adjacent to the biomarkers that contain a significant amount of CG subsequences, methylation of the DNA regions, and/or expression of the genes regulated by the DNA regions can be used to detect cancer cells. Detecting cancer cells allows for diagnostic tests that detect disease, assess the risk of contracting disease, determining a predisposition to disease, stage disease, diagnose disease, monitor disease, and/or aid in the selection of treatment for a person with disease.
II. Methylation Biomarkers
[0119] In some embodiments, the presence or absence or quantity of methylation of the chromosomal DNA within a DNA region or portion thereof (e.g., at least one cytosine) selected from SEQ ID Nos: 213-265 is detected. Portions of the DNA regions described herein will comprise at least one potential methylation site (i.e., a cytosine) and can in some embodiments generally comprise 2, 3, 4, 5, 10, or more potential methylation sites. In some embodiments, the methylation status of all cytosines within at least 20, 50, 100, 200, 500 or more contiguous base pairs of the DNA region are determined.
[0120] In some embodiments, the methylation of more than one DNA region (or portion thereof) is detected. In some embodiments, the methylation status at least one cytosine in 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52 or 53 of the DNA regions is determined.
[0121] In some embodiments of the invention, the methylation of a DNA region or portion thereof is determined and then compared (e.g., normalized) to the methylation of a control locus. Typically the control locus will have a known, relatively constant, methylation status. For example, the control sequence can be previously determined to have no, some, or a high amount of methylation, thereby providing a relative constant value to control for error in detection methods, etc., unrelated to the presence or absence of cancer. In some embodiments, the control locus is endogenous, i.e., is part of the genome of the individual sampled. For example, in mammalian cells, the testes-specific histone 2B gene (hTH2B in human) gene is known to be methylated in all somatic tissues except testes. Alternatively, the control locus can be an exogenous locus, i.e., a DNA sequence spiked into the sample in a known quantity and having a known methylation status.
[0122] A DNA region comprises a nucleic acid including one or more methylation sites of interest (e.g., a cytosine, a "microarray feature" as exemplified in FIG. 1C, or an amplicon amplified from select primers as exemplified in FIG. 1D) and flanking nucleic acid sequences (i.e., "wingspan") of up to 4 kilobases (kb) in either or both of the 3' or 5' direction from the amplicon. This range corresponds to the lengths of DNA fragments obtained by randomly shearing the DNA before screening for differential methylation between DNA in two or more samples (e.g., carrying out methods used to initially identify differentially methylated sequences as described in the Examples, below). In some embodiments, the wingspan of the one or more DNA regions is about 0.5 kb, 0.75 kb, 1.0 kb, 1.5 kb, 2.0 kb, 2.5 kb, 3.0 kb, 3.5 kb or 4.0 kb.
[0123] In some cases, the DNA region comprises more nucleotides than simply the wingspan of the discovery method because the relevant microarray feature or amplicon reside in a larger region of higher CG density in the chromosome. This range corresponds to identified lengths of nucleic acid sequences having higher CG density (e.g., a "CG island") than flanking nucleic acid sequences (e.g., "local minimum" CG density) (see, for example, FIG. 8). DNA regions having extended sequences of heightened CG density include, for example, sequences 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265 (see, Table 2 and section "SEQUENCE LISTING").
[0124] The methylation sites in a DNA region can reside in non-coding transcriptional control sequences (e.g., promoters, enhancers, etc.) or in coding sequences, including introns and exons of the designated genes listed in Tables 1 and 2 and in section "SEQUENCE LISTING." In some embodiments, the methods comprise detecting the methylation status in the promoter regions (e.g., comprising the nucleic acid sequence that is about 1.0 kb, 1.5 kb, 2.0 kb, 2.5 kb, 3.0 kb, 3.5 kb or 4.0 kb 5' from the transcriptional start site through to the transcriptional start site) of one or more of the genes identified in Tables 1 and 2 and in the "SEQUENCE LISTING" section.
[0125] The DNA regions of the invention also include naturally occurring variants, including for example, variants occurring in different subject populations and variants arising from single nucleotide polymorphisms (SNPs). Variants include nucleic acid sequences from the same DNA region (e.g., as set forth in Tables 1 and 2 and in the "SEQUENCE LISTING" section) sharing at least 90%, 95%, 98%, 99% sequence identity, i.e., having one or more deletions, additions, substitutions, inverted sequences, etc., relative to the DNA regions described herein.
III. Methods for Determining Methylation
[0126] Any method for detecting DNA methylation can be used in the methods of the present invention.
[0127] In some embodiments, methods for detecting methylation include randomly shearing or randomly fragmenting the genomic DNA, cutting the DNA with a methylation-dependent or methylation-sensitive restriction enzyme and subsequently selectively identifying and/or analyzing the cut or uncut DNA. Selective identification can include, for example, separating cut and uncut DNA (e.g., by size) and quantifying a sequence of interest that was cut or, alternatively, that was not cut. See, e.g., U.S. Pat. No. 7,186,512. Alternatively, the method can encompass amplifying intact DNA after restriction enzyme digestion, thereby only amplifying DNA that was not cleaved by the restriction enzyme in the area amplified. See, e.g., U.S. patent application Ser. Nos. 10/971,986; 11/071,013; and 10/971,339. In some embodiments, amplification can be performed using primers that are gene specific. Alternatively, adaptors can be added to the ends of the randomly fragmented DNA, the DNA can be digested with a methylation-dependent or methylation-sensitive restriction enzyme, intact DNA can be amplified using primers that hybridize to the adaptor sequences. In this case, a second step can be performed to determine the presence, absence or quantity of a particular gene in an amplified pool of DNA. In some embodiments, the DNA is amplified using real-time, quantitative PCR.
[0128] In some embodiments, the methods comprise quantifying the average methylation density in a target sequence within a population of genomic DNA. In some embodiments, the method comprises contacting genomic DNA with a methylation-dependent restriction enzyme or methylation-sensitive restriction enzyme under conditions that allow for at least some copies of potential restriction enzyme cleavage sites in the locus to remain uncleaved; quantifying intact copies of the locus; and comparing the quantity of amplified product to a control value representing the quantity of methylation of control DNA, thereby quantifying the average methylation density in the locus compared to the methylation density of the control DNA.
[0129] The quantity of methylation of a locus of DNA can be determined by providing a sample of genomic DNA comprising the locus, cleaving the DNA with a restriction enzyme that is either methylation-sensitive or methylation-dependent, and then quantifying the amount of intact DNA or quantifying the amount of cut DNA at the DNA locus of interest. The amount of intact or cut DNA will depend on the initial amount of genomic DNA containing the locus, the amount of methylation in the locus, and the number (i.e., the fraction) of nucleotides in the locus that are methylated in the genomic DNA. The amount of methylation in a DNA locus can be determined by comparing the quantity of intact DNA or cut DNA to a control value representing the quantity of intact DNA or cut DNA in a similarly-treated DNA sample. The control value can represent a known or predicted number of methylated nucleotides. Alternatively, the control value can represent the quantity of intact or cut DNA from the same locus in another (e.g., normal, non-diseased) cell or a second locus.
[0130] By using at least one methylation-sensitive or methylation-dependent restriction enzyme under conditions that allow for at least some copies of potential restriction enzyme cleavage sites in the locus to remain uncleaved and subsequently quantifying the remaining intact copies and comparing the quantity to a control, average methylation density of a locus can be determined. If the methylation-sensitive restriction enzyme is contacted to copies of a DNA locus under conditions that allow for at least some copies of potential restriction enzyme cleavage sites in the locus to remain uncleaved, then the remaining intact DNA will be directly proportional to the methylation density, and thus may be compared to a control to determine the relative methylation density of the locus in the sample. Similarly, if a methylation-dependent restriction enzyme is contacted to copies of a DNA locus under conditions that allow for at least some copies of potential restriction enzyme cleavage sites in the locus to remain uncleaved, then the remaining intact DNA will be inversely proportional to the methylation density, and thus may be compared to a control to determine the relative methylation density of the locus in the sample. Such assays are disclosed in, e.g., U.S. patent application Ser. No. 10/971,986.
[0131] Kits for the above methods can include, e.g., one or more of methylation-dependent restriction enzymes, methylation-sensitive restriction enzymes, amplification (e.g., PCR) reagents, probes and/or primers.
[0132] Quantitative amplification methods (e.g., quantitative PCR or quantitative linear amplification) can be used to quantify the amount of intact DNA within a locus flanked by amplification primers following restriction digestion. Methods of quantitative amplification are disclosed in, e.g., U.S. Pat. Nos. 6,180,349; 6,033,854; and 5,972,602, as well as in, e.g., Gibson et al., Genome Research 6:995-1001 (1996); DeGraves, et al., Biotechniques 34(1):106-10, 112-5 (2003); Deiman B, et al., Mol. Biotechnol. 20(2):163-79 (2002). Amplifications may be monitored in "real time."
[0133] Additional methods for detecting DNA methylation can involve genomic sequencing before and after treatment of the DNA with bisulfite. See, e.g., Frommer et al., Proc. Natl. Acad. Sci. USA 89:1827-1831 (1992). When sodium bisulfite is contacted to DNA, unmethylated cytosine is converted to uracil, while methylated cytosine is not modified.
[0134] In some embodiments, restriction enzyme digestion of PCR products amplified from bisulfite-converted DNA is used to detect DNA methylation. See, e.g., Sadri & Hornsby, Nucl. Acids Res. 24:5058-5059 (1996); Xiong & Laird, Nucleic Acids Res. 25:2532-2534 (1997).
[0135] In some embodiments, a MethyLight assay is used alone or in combination with other methods to detect DNA methylation (see, Eads et al., Cancer Res. 59:2302-2306 (1999)). Briefly, in the MethyLight process genomic DNA is converted in a sodium bisulfite reaction (the bisulfite process converts unmethylated cytosine residues to uracil). Amplification of a DNA sequence of interest is then performed using PCR primers that hybridize to CpG dinucleotides. By using primers that hybridize only to sequences resulting from bisulfite conversion of unmethylated DNA, (or alternatively to methylated sequences that are not converted) amplification can indicate methylation status of sequences where the primers hybridize. Similarly, the amplification product can be detected with a probe that specifically binds to a sequence resulting from bisulfite treatment of a unmethylated (or methylated) DNA. If desired, both primers and probes can be used to detect methylation status. Thus, kits for use with MethyLight can include sodium bisulfite as well as primers or detectably-labeled probes (including but not limited to Taqman or molecular beacon probes) that distinguish between methylated and unmethylated DNA that have been treated with bisulfite. Other kit components can include, e.g., reagents necessary for amplification of DNA including but not limited to, PCR buffers, deoxynucleotides; and a thermostable polymerase.
[0136] In some embodiments, a Ms-SNuPE (Methylation-sensitive Single Nucleotide Primer Extension) reaction is used alone or in combination with other methods to detect DNA methylation (see, Gonzalgo & Jones, Nucleic Acids Res. 25:2529-2531 (1997)). The Ms-SNuPE technique is a quantitative method for assessing methylation differences at specific CpG sites based on bisulfite treatment of DNA, followed by single-nucleotide primer extension (Gonzalgo & Jones, supra). Briefly, genomic DNA is reacted with sodium bisulfite to convert unmethylated cytosine to uracil while leaving 5-methylcytosine unchanged. Amplification of the desired target sequence is then performed using PCR primers specific for bisulfite-converted DNA, and the resulting product is isolated and used as a template for methylation analysis at the CpG site(s) of interest.
[0137] Typical reagents (e.g., as might be found in a typical Ms-SNuPE-based kit) for Ms-SNuPE analysis can include, but are not limited to: PCR primers for specific gene (or methylation-altered DNA sequence or CpG island); optimized PCR buffers and deoxynucleotides; gel extraction kit; positive control primers; Ms-SNuPE primers for a specific gene; reaction buffer (for the Ms-SNuPE reaction); and detectably-labeled nucleotides. Additionally, bisulfite conversion reagents may include: DNA denaturation buffer; sulfonation buffer; DNA recovery regents or kit (e.g., precipitation, ultrafiltration, affinity column); desulfonation buffer; and DNA recovery components.
[0138] In some embodiments, a methylation-specific PCR ("MSP") reaction is used alone or in combination with other methods to detect DNA methylation. An MSP assay entails initial modification of DNA by sodium bisulfite, converting all unmethylated, but not methylated, cytosines to uracil, and subsequent amplification with primers specific for methylated versus unmethylated DNA. See, Herman et al., Proc. Natl. Acad. Sci. USA 93:9821-9826, (1996); U.S. Pat. No. 5,786,146.
[0139] Additional methylation detection methods include, but are not limited to, methylated CpG island amplification (see, Toyota et al., Cancer Res. 59:2307-12 (1999)) and those described in, e.g., U.S. Patent Publication 2005/0069879; Rein, et al. Nucleic Acids Res. 26 (10): 2255-64 (1998); Olek, et al. Nat. Genet. 17(3): 275-6 (1997); and PCT Publication No. WO 00/70090.
[0140] It is well known that methylation of genomic DNA can affect expression (transcription and/or translation) of nearby gene sequences. Therefore, in some embodiments, the methods include the step of correlating the methylation status of at least one cytosine in a DNA region with the expression of nearby coding sequences, as described in Tables 1 and 2 and in the "SEQUENCE LISTING" section. For example, expression of gene sequences within about 1.0 kb, 1.5 kb, 2.0 kb, 2.5 kb, 3.0 kb, 3.5 kb or 4.0 kb in either the 3' or 5' direction from the cytosine of interest in the DNA region can be detected. Methods for measuring transcription and/or translation of a particular gene sequence are well known in the art. See, for example, Ausubel, Current Protocols in Molecular Biology, 1987-2006, John Wiley & Sons; and Sambrook and Russell, Molecular Cloning: A Laboratory Manual, 3rd Edition, 2000, Cold Spring Harbor Laboratory Press. In some embodiments, the gene or protein expression of a gene in Tables 1 and 2 and in the "SEQUENCE LISTING" section is compared to a control, for example, the methylation status in the DNA region and/or the expression of a nearby gene sequence, and/or the same gene sequence from a sample from an individual known to be negative for cancer or known to be positive for cancer, or to an expression level that distinguishes between cancer and noncancer states. Such methods, like the methods of detecting methylation described herein, are useful in providing diagnosis, prognosis, etc., of breast cancer.
[0141] In some embodiments, the methods further comprise the step of correlating the methylation status and expression of one or more of the gene regions identified in Tables 1 and 2 and in the "SEQUENCE LISTING" section.
IV. CANCER DETECTION
[0142] The present biomarkers and methods can be used in the detection, diagnosis, prognosis, classification, and treatment of a number of types of cancers. A cancer at any stage of progression can be detected, such as primary, metastatic, and recurrent cancers. Information regarding numerous types of cancer can be found, e.g., from the American Cancer Society (available on the worldwide web at cancer.org), or from, e.g., Harrison's Principles of Internal Medicine, Kaspar, et al., eds., 16th Edition, 2005, McGraw-Hill, Inc. Exemplary cancers that can be detected include, e.g., breast cancers, including ductal carcinoma, as well as lung, renal, liver, ovarian, head and neck, thyroid, bladder, cervical, colon, endometrial, esophageal, or prostate cancer or melanoma.
[0143] The present invention provides methods for determining whether or not a mammal (e.g., a human) has cancer, i.e., whether or not a biological sample taken from a mammal contains cancerous cells, estimating the risk or likelihood of a mammal developing cancer, classifying cancer types and stages, and monitoring the efficacy of anti-cancer treatment or selecting the appropriate anti-cancer treatment in a mammal with cancer. Such methods are based on the discovery that cancer cells have a different methylation status than normal cells in the DNA regions described in the invention. Accordingly, by determining whether or not a cell contains differentially methylated sequences in the DNA regions as described herein, it is possible to determine whether or not the cell is cancerous.
[0144] In numerous embodiments of the present invention, the presence of methylated nucleotides in the diagnostic biomarker sequences of the invention is detected in a biological sample, thereby detecting the presence or absence of cancerous cells in the mammal from which the biological sample was taken. In some embodiments, the biological sample comprises a tissue sample from a tissue suspected of containing cancerous cells. For example, in an individual suspected of having cancer, breast tissue, lymph tissue, lung tissue, brain tissue, or blood can be evaluated. Alternatively, lung, renal, liver, ovarian, head and neck, thyroid, bladder, cervical, colon, endometrial, esophageal, prostate, or skin tissue can be evaluated. The tissue or cells can be obtained by any method known in the art including, e.g., by surgery, biopsy, phlebotomy, swab, nipple discharge, stool, etc. In other embodiments, a tissue sample known to contain cancerous cells, e.g., from a tumor, will be analyzed for the presence or quantity of methylation at one or more of the diagnostic biomarkers of the invention to determine information about the cancer, e.g., the efficacy of certain treatments, the survival expectancy of the individual, etc. In some embodiments, the methods will be used in conjunction with additional diagnostic methods, e.g., detection of other cancer biomarkers, etc.
[0145] The methods of the invention can be used to evaluate individuals known or suspected to have cancer or as a routine clinical test, i.e., in an individual not necessarily suspected to have cancer.
[0146] Further, the present methods may be used to assess the efficacy of a course of treatment. For example, the efficacy of an anti-cancer treatment can be assessed by monitoring DNA methylation of the biomarker sequences described herein over time in a mammal having cancer. For example, a reduction or absence of methylation in any of the diagnostic biomarkers of the invention in a biological sample taken from a mammal following a treatment, compared to a level in a sample taken from the mammal before, or earlier in, the treatment, indicates efficacious treatment.
[0147] The methods detecting cancer can comprise the detection of one or more other cancer-associated polynucleotide or polypeptides sequences. Accordingly, detection of methylation of any one or more of the diagnostic biomarkers of the invention can be used either alone, or in combination with other biomarkers, for the diagnosis or, prognosis of cancer.
[0148] The methods of the present invention can be used to determine the optimal course of treatment in a mammal with cancer. For example, the presence of methylated DNA within any of the diagnostic biomarkers of the invention or an increased quantity of methylation within any of the diagnostic biomarkers of the invention can indicate a reduced survival expectancy of a mammal with cancer, thereby indicating a more aggressive treatment for the mammal. In addition, a correlation can be readily established between the presence, absence or quantity of methylation at a diagnostic biomarker, as described herein, and the relative efficacy of one or another anti-cancer agent. Such analyses can be performed, e.g., retrospectively, i.e., by detecting methylation in one or more of the diagnostic genes in samples taken previously from mammals that have subsequently undergone one or more types of anti-cancer therapy, and correlating the known efficacy of the treatment with the presence, absence or levels of methylation of one or more of the diagnostic biomarkers.
[0149] In making a diagnosis, prognosis, risk assessment or classification, in monitoring disease, or in determining the most beneficial course of treatment based on the presence or absence of methylation in at least one of the diagnostic biomarkers, the quantity of methylation may be compared to a threshold value that distinguishes between one diagnosis, prognosis, risk assessment, classification, etc., and another. For example, a threshold value can represent the degree of methylation found at a particular DNA region that adequately distinguishes between breast cancer samples and normal breast samples with a desired level of sensitivity and specificity. It is understood that a threshold value will likely vary depending on the assays used to measure methylation, but it is also understood that it is a relatively simple matter to determine a threshold value or range by measuring methylation of a DNA sequence in diseased and normal samples using the particular desired assay and then determining a value that distinguishes at least a majority of the cancer samples from a majority of non-cancer samples. An example of this is shown in FIG. 6 and the accompanying text in the examples. If methylation of two or more DNA regions is detected, two or more different threshold values (one for each DNA region) will often, but not always, be used. Comparisons between a quantity of methylation of a sequence in a sample and a threshold value in any way known in the art. For example; a manual comparison can be made or a computer can compare and analyze the values to detect disease, assess the risk of contracting disease, determining a predisposition to disease, stage disease, diagnose disease, monitor, or aid in the selection of treatment for a person with disease.
[0150] In some embodiments, threshold values provide at least a specified sensitivity and specificity for detection of a particular cancer type. In some embodiments, the threshold value allows for at least a 50%, 60%, 70%, or 80% sensitivity and specificity for detection of a specific cancer, e.g., breast, lung, renal, liver, ovarian, head and neck, thyroid, bladder, cervical, colon, endometrial, esophageal, prostate cancer or melanoma. More detail regarding specificity and sensitivity for various cancers can be found in, e.g., Tables 5-6, and 8-20.
[0151] In embodiments involving prognosis of cancer (including, for example, the prediction of progression of non-malignant lesions to invasive carcinoma, prediction of metastasis, prediction of disease recurrance or prediction of a response to a particular treatment), in some embodiments, the threshold value is set such that there is at least 10, 20, 30, 40, 50, 60, 70, 80% or more sensitivity and at least 70% specificity with regard to detecting cancer.
[0152] In some embodiments, the methods comprise recording a diagnosis, prognosis, risk assessment or classification, based on the methylation status determined from an individual. Any type of recordation is contemplated, including electronic recordation, e.g., by a computer.
V. Kits
[0153] This invention also provides kits for the detection and/or quantification of the diagnostic biomarkers of the invention, or expression or methylation thereof using the methods described herein.
[0154] For kits for detection of methylation, the kits of the invention can comprise at least one polynucleotide that hybridizes to at least one of the diagnostic biomarker sequences of the invention and at least one reagent for detection of gene methylation. Reagents for detection of methylation include, e.g., sodium bisulfite, polynucleotides designed to hybridize to sequence that is the product of a biomarker sequence of the invention if the biomarker sequence is not methylated (e.g., containing at least one C→U conversion), and/or a methylation-sensitive or methylation-dependent restriction enzyme. The kits can provide solid supports in the form of an assay apparatus that is adapted to use in the assay. The kits may further comprise detectable labels, optionally linked to a polynucleotide, e.g., a probe, in the kit. Other materials useful in the performance of the assays can also be included in the kits, including test tubes, transfer pipettes, and the like. The kits can also include written instructions for the use of one or more of these reagents in any of the assays described herein.
[0155] In some embodiments, the kits of the invention comprise one or more (e.g., 1, 2, 3, 4, or more) different polynucleotides capable of specifically amplifying at least a portion of a DNA region where the DNA region is a sequence selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265. Optionally, one or more detectably-labeled polypeptide capable of hybridizing to the amplified portion can also be included in the kit. In some embodiments, the kits comprise sufficient primers to amplify 2, 3, 4, 5, 6, 7, 8, 9, 10, or more different DNA regions or portions thereof, and optionally include detectably-labeled polynucleotides capable of hybridizing to each amplified DNA region or portion thereof. The kits further can comprise a methylation-dependent or methylation sensitive restriction enzyme and/or sodium bisulfite.
[0156] In some embodiments, the kits comprise sodium bisulfite, primers and adapters (e.g., oligonucleotides that can be ligated or otherwise linked to genomic fragments) for whole genome amplification, and polynucleotides (e.g., detectably-labeled polynucleotoides) to quantify the presence of the converted methylated and or the converted unmethylated sequence of at least one cytosine from a DNA region that is selected from the group consisting of SEQ ID NOs:213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265.
[0157] In some embodiments, the kits comprise a methylation sensing restriction enzymes (e.g., a methylation-dependent restriction enzyme and/or a methylation-sensitive restriction enzyme), primers and adapters for whole genome amplification, and polynucleotides to quantify the number of copies of at least a portion of a DNA region where the DNA region is selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265.
[0158] In some embodiments, the kits comprise a methylation binding moiety and one or more polynucleotides to quantify the number of copies of at least a portion of a DNA region where the DNA region is selected from the group consisting of SEQ ID NOs: 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, and 265. A methylation binding moiety refers to a molecule (e.g., a polypeptide) that specifically binds to methyl-cytosine. Examples include restriction enzymes or fragments thereof that lack DNA cutting activity but retain the ability to bind methylated DNA, antibodies that specifically bind to methylated DNA, etc.).
VI. Computer-Based Methods
[0159] The calculations for the methods described herein can involve computer-based calculations and tools. For example, a methylation value for a DNA region or portion thereof can be compared by a computer to a threshold value, as described herein. The tools are advantageously provided in the form of computer programs that are executable by a general purpose computer system (referred to herein as a "host computer") of conventional design. The host computer may be configured with many different hardware components and can be made in many dimensions and styles (e.g., desktop PC, laptop, tablet PC, handheld computer, server, workstation, mainframe). Standard components, such as monitors, keyboards, disk drives, CD and/or DVD drives, and the like, may be included. Where the host computer is attached to a network, the connections may be provided via any suitable transport media (e.g., wired, optical, and/or wireless media) and any suitable communication protocol (e.g., TCP/IP); the host computer may include suitable networking hardware (e.g., modem, Ethernet card, WiFi card). The host computer may implement any of a variety of operating systems, including UNIX, Linux, Microsoft Windows, MacOS, or any other operating system.
[0160] Computer code for implementing aspects of the present invention may be written in a variety of languages, including PERL, C, C++, Java, JavaScript, VBScript, AWK, or any other scripting or programming language that can be executed on the host computer or that can be compiled to execute on the host computer. Code may also be written or distributed in low level languages such as assembler languages or machine languages.
[0161] The host computer system advantageously provides an interface via which the user controls operation of the tools. In the examples described herein, software tools are implemented as scripts (e.g., using PERL), execution of which can be initiated by a user from a standard command line interface of an operating system such as Linux or UNIX. Those skilled in the art will appreciate that commands can be adapted to the operating system as appropriate. In other embodiments, a graphical user interface may be provided, allowing the user to control operations using a pointing device. Thus, the present invention is not limited to any particular user interface.
[0162] Scripts or programs incorporating various features of the present invention may be encoded on various computer readable media for storage and/or transmission. Examples of suitable media include magnetic disk or tape, optical storage media such as compact disk (CD) or DVD (digital versatile disk), flash memory, and carrier signals adapted for transmission via wired, optical, and/or wireless networks conforming to a variety of protocols, including the Internet.
EXAMPLES
Example 1
Identification of Breast Cancer DNA Methylation Biomarkers
[0163] Loci that are differentially methylated in breast tumors relative to matched adjacent histologically normal breast tissue were identified using a DNA microarray-based technology platform (U.S. Pat. No. 7,186,512) that utilizes the methylation-dependent restriction enzyme McrBC. In this discovery phase, 10 infiltrating ductal breast carcinomas (9 Stage II, 1 Stage III) and 10 matched adjacent histologically normal breast tissue samples were analyzed. Purified genomic DNA from each sample (60 μg) was randomly sheared to a range of 1 to 4 kb. The sheared DNA of each sample was then split into four equal portions of 15 μg each. Two portions were digested with McrBC under the following conditions: 15 μg sheared genomic DNA, 1×NEB2 buffer (New England Biolabs), 0.1 mg/mL bovine serum albumin (New England Biolabs), 2 mM GTP (Roche) and 120 units of McrBC enzyme (New England Biolabs) in a total volume of 600 μL at 37° C. for approximately 12 hours. These two portions represent a technical replicate of McrBC digestion (Treated 1 and Treated 2). The remaining two 15 μg portions were mock treated under identical conditions with the exception that 12 μL of sterile 50% glycerol were added instead of McrBC enzyme. These two portions represent a technical replicate of mock treatment (Untreated 1 and Untreated 2). All reactions were treated with 5 μL proteinase K (50 mg/mL) for 1 hour at 50° C., and precipitated with EtOH under standard conditions. Pellets were washed twice with 70% EtOH, dried and resuspended in 30 μL H2O, Samples were then resolved on a 1% low melting point SeaPlaque GTG Agarose gel (Cambridge Bio Sciences). Untreated 1 and Treated 1 portions were resolved side-by-side, as were Untreated 2 and Treated 2 portions. 1 kb DNA sizing ladder was resolved adjacent to each untreated/treated pair to guide accurate gel slice excision. Gels were visualized with long-wave UV, and gel slices including DNA within the modal size range of the untreated fraction (approximately 1-4 kb) were excised with a clean razor blade. DNA was extracted from gel slices using gel extraction kits (Qiagen).
[0164] McrBC recognizes a pair of methylated cytosine residues in the context 5'-PumC (N40-2000) PumC-3' (where Pu=A or G, mC=5-methylcytosine, and N=any nucleotide), and cleaves within approximately 30 base-pairs from one of the methylated cytosine residues. Therefore, loci that include high local densities of PumC will be cleaved to a greater extent than loci that include low local densities of PumC. Since Untreated and Treated portions were resolved by agarose gel electrophoresis, and DNA within the modal size range of the Untreated portions were excised and gel extracted, the Untreated portions represent the entire fragmented genome of the sample while the Treated portions are depleted of DNA fragments including PumC. Fractions were analyzed using a duplicated dye swap microarray hybridization paradigm. For example, equal mass (200 ng) of Untreated 1 and Treated I fraction DNA were used as template for labeling with Cy3 and Cy5, respectively, and hybridized to a DNA microarray (described below). Equal mass (200 ng) of the same Untreated 1 and Treated 1 fraction DNA were used as template for labeling with Cy5 and Cy3, respectively, and hybridized to a second DNA microarray (these two hybridizations represent a dye swap of Untreated 1/Treated 1 fractions). Equal mass (200 ng) of Untreated 2 and Treated 2 fraction DNA were used as template for labeling with Cy3 and Cy5, respectively, and hybridized to a third DNA microarray. Finally, equal mass (200 ng) of Untreated 2 and Treated 2 fraction DNA were used as template for labeling with Cy5 and Cy3, respectively, and hybridized to a fourth DNA microarray (the final two hybridizations represent a technical replicate of the first dye swap). All 20 DNA samples (10 tumor samples and 10 adjacent normal samples) were analyzed in this way. Therefore, the discovery experiment included a total of 80 microarray hybridizations.
[0165] The microarray described in this Example consists of 85,176 features. Each 60mer oligonucleotide feature is represented by four replicates per microarray slide, yielding a total of 21,294 unique feature probes. The features represent 19,595 randomly selected human transcriptional start sites (TSS) representing 79% of the identified human genes, 1395 GenBank BAC annotated CG islands (CGi), 161 features spanning ˜165 kb along the MTAPase/CDKN2A/B locus on chromosome 9, 66 additional features dedicated to cancer gene promoters, and 77 features designed as copy number (HERV, LINEs, SINE) and other controls. Together, the TSS features and CGi features scan more than 9000 UCSC annotated human CG islands.
[0166] Following statistical analysis of these datasets, loci that were predicted to be differentially methylated in at least 70% of tumors relative to normal tissues were identified. As described in the Examples below, differential DNA methylation of a collection of 53 loci identified by the microarray discovery experiment described herein was verified within the discovery panel of 10 infiltrating ductal breast carcinomas relative to 10 matched adjacent histologically normal breast samples, as well as validated in larger panels of independent infiltrating ductal breast carcinomas, normal breast samples and normal female peripheral blood samples. Tables 1 and 2 and the "SEQUENCE LISTING" section list the unique microarray feature identifier (Feature name) for each of these 53 loci. Locus number is an arbitrary locus identifier that will be used to identify the loci in the following examples. Of the 53 features, 48 represent sequence within 1 kb of at least one annotated transcribed gene. These are referred to in the table by the Ensembl gene ID, as well as the official gene symbol for each gene (Gene Name). The genomic region in which a given microarray feature can report DNA methylation status is dependent upon the molecular size of the DNA fragments that were labeled for the microarray hybridizations. As described above, DNA in the size range of 1 to 4 kb was purified by agarose gel extraction and used as template for cyanogen dye labeling. Therefore, the genomic region interrogated by each microarray feature is at least 1 kb (i.e., 500 bp upstream and 500 bp downstream of the sequence represented by the microarray feature). Note that 5 features represent loci in which there is no annotated transcribed gene within this 1 kb "wingspan" (Locus numbers 3, 9, 20, 31, and 47). Also note that 8 features represent loci in which more than one annotated transcribed gene falls within wingspan (Locus numbers 21, 26, 27, 29, 35, 38, 39, and 53). DNA methylation at these loci can affect the regulation of any of these neighboring genes, and thus detection of gene expression from neighboring genes is also useful for determining the presence or absence of cancer for numerous types of diagnostic tests.
TABLE-US-00001 TABLE 1 Microarray Features Reporting Differential DNA Methylation And Identity Of Annotated Genes Within 1 kb Of Each Feature. Locus Featurename Number Ensembl Gene ID Gene Name ha1g_00681 1 ENSG00000105997 HOXA3 ha1p_39189 2 ENSG00000121853 GHSR ha1g_00644 3 N/A ha1p_81674 4 ENSG00000174197 MGA ha1p_81149 5 ENSG00000122971 ACADS ha1p_83841 6 ENSG00000178187 ZNF454 ha1p_38705 7 ENSG00000163638 ADAMTS9 ha1p_40164 8 ENSG00000118855 MFSD1 ha1p_23178 9 N/A ha1p_46057 10 ENSG00000132640 BTBD3 ha1p_40959 11 ENSG00000111707 SUDS3 ha1p_104423 12 ENSG00000008441 NFIX ha1g_00847 13 ENSG00000116106 EPHA4 ha1p_08347 14 ENSG00000134802 SLC43A3 ha1g_02416 15 ENSG00000172238 ATOH1 ha1p_87540 16 ENSG00000159403 PREDICTED: similar to Complement C1r subcomponent precursor ha1p_110107 17 ENSG00000122254 HS3ST2 ha1p_89799 18 ENSG00000163739 CXCL1 ha1p_45173 19 ENSG00000120915 EPHX2 ha1p_80771 20 N/A ha1p_69407 21 ENSG00000180667 YOD1 ENSG00000198878 O9P1L8_HUMAN ha1p_05406 22 ENSG00000165556 CDX2 ha1p_80287 23 ENSG00000109113 RAB34 ha1g_02345 24 ENSG00000122592 HOXA7 ha1p_36172 25 ENSG00000185070 FLRT2 ha1p_70459 26 ENSG00000163481 RNF25 ENSG00000163482 STK36 ha1p_105937 27 ENSG00000161551 ZNF577 ENSG00000198093 ZNF649 ha1p_89099 28 ENSG00000062485 CS ha1g_03099 29 ENSG00000066032 CTNNA2 ENSG00000162951 LRRTM1 ha1p_67625 30 ENSG00000130711 PRDM12 ha1g_00218 31 N/A ha1p_12535 32 ENSG00000149090 RAMP ha1p_105474 33 ENSG00000033627 ATP6V0A1 ha1p_74707 34 ENSG00000010278 CD9 ha1p_93325 35 ENSG00000101019 C20 orf44 ENSG00000125965 GDF5 ha1p_101161 36 ENSG00000130176 CNN1 ha1p_101251 37 ENSG00000142235 LMTK3 ha1p_69214 38 ENSG00000158927 C8 orf58 ENSG00000158941 KIAA1967 ENSG00000183646 ha1p_88517 39 ENSG00000101412 E2F1 ENSG00000125967 APBA2BP ha1p_103824 40 ENSG00000167178 ISLR2 ha1p_108445 41 ENSG00000175287 PHYHD1 ha1g_02210 42 ENSG00000151615 POU4F2 ha1p_103872 43 ENSG00000129009 ISLR ha1p_56412 44 ENSG00000175182 C3 orf40 ha1p_18292 45 ENSG00000115561 VPS24 ha1p_12075 46 ENSG00000164619 BMPER ha1p_22519 47 N/A ha1p_29531 48 ENSG00000060718 COL11A1 ha1p_58853 49 ENSG00000113648 H2AFY ha1p_35052 50 ENSG00000111341 MGP ha1p_67002 51 ENSG00000159445 THEM4 ha1p_45580 52 ENSG00000168079 SCARA5 ha1p_12646 53 ENSG00000107833 NPM3 ENSG00000198408 MGEA5
Example 2
Design of Independent DNA Methylation Verification and Validation Assays
[0167] PCR primers that interrogated the 53 loci predicted to be differentially methylated between breast tumor and adjacent histologically normal breast tissue were designed. Due to the functional properties of the enzyme, DNA methylation-dependent depletion of DNA fragments by McrBC is capable of monitoring the DNA methylation status of sequences neighboring the genomic sequences represented by the features on the microarray described in Example 1 (wingspan). Since the size of DNA fragments analyzed as described in Example 1 was approximately 1-4 kb, we selected a 1 kb region spanning the sequence represented by the microarray feature as an estimate of the predicted region of differential methylation. For each locus, PCR primers were selected within this approximately 1 kb region flanking the genomic sequence represented on the DNA microarray (approximately 500 bp upstream and 500 bp downstream). Selection of primer sequences was guided by uniqueness of the primer sequence across the genome, as well as the distribution of purine-CG sequences within the 1 kb region. PCR primer pairs were selected to amplify an approximately 400-600 bp sequence within each 1 kb region. For demonstration, an example of one such PCR amplicon design is shown in FIG. 1. A graphical representation of the transcription start site and 5' structure of one predicted differentially methylated gene is indicated (A). The bar graph (B) indicates the relative local density of purine-CG sequences within this region. The relative position of the DNA microarray feature that reported differential DNA methylation at this locus is indicated by (C). PCR primers were selected to amplify the region indicated by (D). The vertical bars (E and F) represent the microarray DNA methylation measurement representing all breast tumors (E) and all normal breast samples (F). For example, this locus is predicted to be hypermethylated in the breast tumors (positive value) relative to the adjacent normal breast samples (negative value). Suitable PCR cycling conditions for the 53 primer pairs were empirically determined, and amplification of a specific PCR amplicon of the correct size was verified. The sequences of the 53 microarray features, primer pairs and amplicons are indicated in Table 2, and in the "SEQUENCE LISTING" section.
TABLE-US-00002 TABLE 2 Sequence identification numbers for all sequences described in the application. Locus Feature Feature Left Right Annealing Amplicon DNA Selection Number Name Seq. Primer Primer Temp. Seq. Region Seq. Criteria 1 ha1g_00681 1 54 107 66 C. 160 213 CG 2 ha1p_39189 2 55 108 66 C. 161 214 CG 3 ha1g_00644 3 56 109 66 C. 162 215 CG 4 ha1p_81674 4 57 110 66 C. 163 216 CG 5 ha1p_81149 5 58 111 66 C. 164 217 CG 6 ha1p_83841 6 59 112 66 C. 165 218 CG 7 ha1p_38705 7 60 113 66 C. 166 219 CG 8 ha1p_40164 8 61 114 66 C. 167 220 CG 9 ha1p_23178 9 62 115 66 C. 168 221 CG 10 ha1p_46057 10 63 116 66 C. 169 222 CG 11 ha1p_40959 11 64 117 66 C. 170 223 CG 12 ha1p_104423 12 65 118 66 C. 171 224 CG 13 ha1g_00847 13 66 119 66 C. 172 225 CG 14 ha1p_08347 14 67 120 66 C. 173 226 CG 15 ha1g_02416 15 68 121 66 C. 174 227 CG 16 ha1p_87540 16 69 122 66 C. 175 228 CG 17 ha1p_110107 17 70 123 66 C. 176 229 CG 18 ha1p_89799 18 71 124 66 C. 177 230 CG 19 ha1p_45173 19 72 125 66 C. 178 231 CG 20 ha1p_80771 20 73 126 66 C. 179 232 CG 21 ha1p_69407 21 74 127 66 C. 180 233 CG 22 ha1p_05406 22 75 128 66 C. 181 234 CG 23 ha1p_80287 23 76 129 66 C. 182 235 CG 24 ha1g_02345 24 77 130 72 C. 183 236 CG 25 ha1p_36172 25 78 131 72 C. 184 237 CG 26 ha1p_70459 26 79 132 66 C. 185 238 CG 27 ha1p_105937 27 80 133 66 C. 186 239 CG 28 ha1p_89099 28 81 134 66 C. 187 240 CG 29 ha1g_03099 29 82 135 66 C. 188 241 CG 30 ha1p_67625 30 83 136 72 C. 189 242 CG 31 ha1g_00218 31 84 137 66 C. 190 243 CG 32 ha1p_12535 32 85 138 66 C. 191 244 CG 33 ha1p_105474 33 86 139 66 C. 192 245 1 kb 34 ha1p_74707 34 87 140 66 C. 193 246 CG 35 ha1p_93325 35 88 141 66 C. 194 247 1 kb 36 ha1p_101161 36 89 142 66 C. 195 248 1 kb 37 ha1p_101251 37 90 143 66 C. 196 249 1 kb 38 ha1p_69214 38 91 144 66 C. 197 250 1 kb 39 ha1p_88517 39 92 145 66 C. 198 251 CG 40 ha1p_103824 40 93 146 66 C. 199 252 CG 41 ha1p_108445 41 94 147 72 C. 200 253 1 kb 42 ha1g_02210 42 95 148 72 C. 201 254 CG 43 ha1p_103872 43 96 149 66 C. 202 255 CG 44 ha1p_56412 44 97 150 72 C. 203 256 CG 45 ha1p_18292 45 98 151 72 C. 204 257 CG 46 ha1p_12075 46 99 152 66 C. 205 258 CG 47 ha1p_22519 47 100 153 66 C. 206 259 CG 48 ha1p_29531 48 101 154 66 C. 207 260 CG 49 ha1p_58853 49 102 155 66 C. 208 261 CG 50 ha1p_35052 50 103 156 66 C. 209 262 1 kb 51 ha1p_67002 51 104 157 72 C. 210 263 CG 52 ha1p_45580 52 105 158 72 C. 211 264 CG 53 ha1p_12646 53 106 159 66 C. 212 265 CG See, section "SEQUENCE LISTING" for actual sequences as listed by locus number in the table.
Example 3
Verification of Microarray DNA Methylation Predictions
[0168] Initially, the DNA methylation state of these 53 loci was independently assayed in the 10 infiltrating ductal breast carcinoma samples and the 10 matched adjacent histologically normal samples described above (i.e., the discovery tissue panel used for microarray experiments). DNA methylation was assayed by a quantitative PCR approach utilizing digestion by the McrBC restriction enzyme to monitor DNA methylation status. Genomic DNA purified from each sample was split into two equal portions of 9.6 μg. One 9.6 μg portion (Treated Portion) was digested with McrBC in a total volume of 120 μL including 1×NEB2 buffer (New England Biolabs), 0.1 mg/mL bovine serum albumin (New. England Biolabs), 2 mM GTP (Roche) and 80 units of McrBC enzyme (New England Biolabs). The second 9.6 μg portion (Untreated Portion) was treated exactly the same as the Treated Portion, except that 8 μL of sterile 50% glycerol was added instead of McrBC enzyme. Reactions were incubated at 37° C. for approximately 12 hours, followed by incubation at 60° C. for 20 minutes to inactivate McrBC.
[0169] The extent of McrBC cleavage at each locus was monitored by quantitative real-time PCR (qPCR). For each assayed locus, qPCR was performed using 20 ng of the Untreated Portion DNA as template and, separately, using 20 ng of the Treated Portion DNA as template. Each reaction was performed in 10 μL total volume including 1× LightCycler 480 SYBR Green I Master mix (Roche) and 625 nM of each primer. Reactions were run in a Roche LightCycler 480 instrument. Optimal annealing temperatures varied depending on the primer pair. Primer sequences (Left Primer; Right Primer) and appropriate annealing temperatures (Annealing Temp.) are shown in Table 2. Cycling conditions were: 95° C. for 5 min.; 45 cycles of 95° C. for 1 min., [annealing temperature, see Table 2] for 30 sec., 72° C. for 1 min., 83° C. for 2 sec. followed by a plate read. Melting curves were calculated under the following conditions: 95° C. for 5 sec., 65° C. for 1 min., 65° C. to 95° C. at 2.5° C./sec. ramp rate with continuous plate reads. Each Untreated/Treated qPCR reaction pair was performed in duplicate. The difference in the cycle number at which amplification crossed threshold (delta Ct) was calculated for each Untreated/Treated qPCR reaction pair by subtracting the Ct of the Untreated Portion from the Ct of the Treated Portion. Because McrBC-mediated cleavage between the two primers increases the Ct of the Treated Portion, increasing delta Ct values reflect increasing measurements of local DNA methylation densities. The average delta Ct between the two replicate Untreated/Treated qPCR reactions was calculated, as well as the standard deviation between the two delta Ct values.
[0170] For demonstration purposes, amplification profiles for one locus (GHSR) in a tumor sample and a normal sample are shown in FIG. 2. Panel A shows the untreated/treated PCR replicate 1 for amplification of the GHSR amplicon in a breast tumor sample. The delta Ct (Treated 1--Untreated 1) is 5.38 cycles. Panel B shows the untreated/treated PCR replicate 2 for amplification of the same amplicon from the same tumor sample. The delta Ct (Treated 2--Untreated 2) is 5.40 cycles. The average delta Ct of the two replicates is 5.39 cycles, representing a ˜97% reduction of amplifiable copies in the treated relative to the untreated portions [100%-((1/2 delta Ct)×100)]. The standard deviation of the delta Ct's between the two qPCR replicates is 0.01 cycles. Panel C shows the untreated/treated PCR replicate 1 for amplification of the GHSR amplicon in a normal breast sample. The delta Ct (Treated 1--Untreated 1) is 0.18 cycles. Panel D shows the untreated/treated PCR replicate 2 for amplification of the same amplicon from the same normal sample. The delta Ct (Treated 2--Untreated 2) is 0.03 cycles. The average delta Ct of the two replicates is 0.11 cycles, representing a ˜7% reduction of amplifiable copies in the treated relative to the untreated portions. The standard deviation of the delta Ct's between the two qPCR replicates is 0.11 cycles. The average delta Ct of the tumor sample would be scored as a methylated locus. In contrast, the average delta Ct of the normal sample would be scored as a relatively unmethylated locus. An average delta Ct of >1.0 cycle, representing >˜50% reduction of amplifiable copies in the treated relative to the untreated portions, was set as the threshold for scoring a sample as positive for DNA methylation. Any average delta Ct measurement with a standard deviation >1.0 cycle in qPCR replicates was excluded as an unreliable measurement (ND in FIG. 3). Finally, any average delta Ct<0 was adjusted to 0.
[0171] FIG. 3 shows the results of the DNA methylation measurements for the 53 loci in the 10 tumor samples and 10 normal samples used in the microarray discovery experiment. Open boxes represent loci that are unmethylated (average delta Ct<1.0), grey boxes represent loci that are methylated (average delta Ct>1 and <2), and black boxes represent loci that are densely methylated (average delta Ct>2).
Example 4
Validation of DNA Methylation Changes in Independent Breast Tumor and Normal Breast Samples
[0172] The differential DNA methylation status of the 53 loci was further validated by analyzing an independent panel of 16 infiltrating ductal breast carcinoma samples (1 Stage I, 4 Stage II, 11Stage III) and 25 normal breast tissue samples. The normal breast tissues included in this panel were obtained from biopsies unrelated to breast cancer. Each sample was split into two equal portions of 4 μg. One portion was digested with McrBC (Treated Portion) in a total volume of 200 μL including 1×NEB2 buffer (New England Biolabs), 0.1 mg/mL bovine serum albumin (New England Biolabs), 2 mM GTP (Roche) and 32 units McrBC (New England Biolabs). The second portion was mock treated under identical conditions, except that 3.2 μL sterile 50% glycerol was added instead of McrBC enzyme (Untreated Portion). Samples were incubated at 37° C. for approximately 12 hours, followed by incubation at 60° C. to inactivate the McrBC enzyme. qPCR reactions and data analysis were performed as described in Example 3.
[0173] The DNA methylation state measurements are summarized in FIG. 4. As described above, each locus was scored as unmethylated (average delta Ct<1.0, open boxes), methylated (average delta Ct>1.0 and <2.0, grey boxes) or densely methylated (average delta Ct>2.0, black boxes). Measurements with a standard deviation between pPCR replicates >1 cycle were not included in the analysis (ND). Table 3 indicates the percent sensitivity and specificity for each locus. Sensitivity reflects the frequency of scoring a known tumor sample as positive for DNA methylation at each locus. Specificity reflects the frequency of scoring a known normal sample as negative for DNA methylation at each locus. As described above, an average delta Ct>1.0 (Treated Portion--Untreated Portion) was used as a threshold to score a sample as positive for DNA methylation at each locus (representing >˜50% depletion of amplifiable molecules in the DNA methylation-dependent restricted population relative to the untreated population). Percent sensitivity was calculated as the number of tumor samples with an average delta Ct>1.0 divided by the total number of tumor samples analyzed for that locus (i.e. excluding any measurements with a standard deviation between qPCR replicates >1 cycle)×100. Percent specificity was calculated as (1--(the number of normal samples with an average delta Ct>1.0 divided by the total number of normal samples analyzed for that locus))×100. As shown in Table 3, the 53 loci have sensitivities >13% and specificities >80%. Notably, 33 of the 53 loci have 100% specificity. It is important to point out that the sensitivity and specificity of the differential DNA methylation status of any given locus may be increased by further optimization of the precise local genetic region interrogated by a DNA methylation-sensing assay.
TABLE-US-00003 TABLE 3A Sensitivity and specificity of differentially methylated loci in a panel of 25 normal breast and 16 breast tumor samples. FEATURE LOCUS ID NUMBER SENSITIVITY SPECIFICITY ha1g_00681 1 86% 100% ha1p_39189 2 81% 100% ha1g_00644 3 79% 100% ha1p_81674 4 69% 100% ha1p_81149 5 69% 100% ha1p_83841 6 69% 100% ha1p_38705 7 63% 100% ha1p_40164 8 63% 100% ha1p_23178 9 63% 100% ha1p_46057 10 56% 100% ha1p_40959 11 56% 100% ha1p_104423 12 50% 100% ha1g_00847 13 50% 100% ha1p_08347 14 50% 100% ha1g_02416 15 44% 100% ha1p_87540 16 44% 100% ha1p_110107 17 38% 100% ha1p_89799 18 31% 100% ha1p_45173 19 31% 100% ha1p_80771 20 25% 100% ha1p_69407 21 25% 100% ha1p_05406 22 25% 100% ha1p_80287 23 25% 100% ha1g_02345 24 20% 100% ha1p_36172 25 20% 100% hal p_70459 26 19% 100% ha1p_105937 27 19% 100% ha1p_89099 28 19% 100% ha1g_03099 29 14% 100% ha1p_67625 30 13% 100% ha1g_00218 31 13% 100% ha1p_12535 32 75% 96% ha1p_105474 33 75% 96% ha1p_74707 34 69% 96% ha1p_93325 35 69% 96% ha1p_101161 36 56% 96% ha1p_101251 37 87% 96% ha1p_69214 38 81% 96% ha1p_88517 39 69% 96% ha1p_103824 40 17% 96% ha1p_108445 41 60% 95% ha1g_02210 42 18% 95% ha1p_103872 43 94% 92% ha1p_56412 44 79% 92% ha1p_18292 45 60% 91% ha1p_12075 46 31% 90% ha1p_22519 47 88% 88% ha1p_29531 48 88% 88% ha1p_58853 49 50% 88% ha1p_35052 50 31% 88% ha1p_67002 51 64% 83% ha1p_45580 52 40% 83% ha1p_12646 53 81% 80%
Example 5
Further Validation of Selected DNA Methylation Biomarkers in a Larger Panel of Breast Tumor Samples, Normal Breast Samples, and Normal Female Peripheral Blood Samples
[0174] A panel of 15 loci were selected for further validation in a panel of 9 additional infiltrating ductal breast carcinoma samples, bringing the total number of tumor samples analyzed to 25 (1 Stage II, 8 Stage III). In addition, 25 normal female peripheral blood samples were analyzed. Samples were treated and analyzed as described in Example 4. FIG. 5 shows the results of these analyses, including the 25 normal breast samples described in Example 4. As shown in Table 4, these loci display >17% sensitivity, >92% specificity relative to normal breast tissue, and >92% specificity relative to normal female peripheral blood.
TABLE-US-00004 TABLE 4 Sensitivity and specificity of differentially methylated loci in a panel of 25 normal breast and 25 breast tumor samples and 25 normal blood samples. SPECIFICITY FEATURE LOCUS SENSI- VS NORMAL SPECIFICITY ID NUMBER TIVITY BREAST VS BLOOD ha1p_39189 2 84% 100% 96% ha1g_00644 3 83% 100% 100% ha1p_81674 4 76% 100% 95% ha1p_74707 34 72% 96% 100% ha1p_101251 37 88% 96% 92% ha1g_02416 15 54% 100% 100% ha1p_110107 17 52% 100% 100% ha1p_89799 18 40% 100% 100% ha1p_80771 20 36% 100% 100% ha1p_69407 21 26% 92% 96% ha1p_05406 22 32% 100% 100% ha1g_02345 24 17% 100% 100% ha1p_36172 25 38% 100% 100% ha1p_70459 26 24% 100% 96% ha1p_67625 30 35% 100% 100%
Example 6
Demonstration of a DNA Methylation Measurement Threshold
[0175] In the examples above, a threshold for scoring differential methylation (average delta Ct>1.0) was established and indiscriminately applied to all loci. However, the most informative threshold is dependent upon the specific locus in question. This is demonstrated in FIG. 6. The graph shows the average delta Ct (Treated Portion--Untreated Portion) for the analyzed region of the GHSR locus in 25 tumor samples, 25 normal breast samples, and 24 normal female peripheral blood samples. Using an average delta Ct threshold of >1.0 as the criteria for a positive DNA methylation measurement, sensitivity is 84%, specificity relative to normal tissue is 100% and specificity relative to blood is 96% (Table 4). However, an optimal threshold may be set for each individual locus, and this threshold is dependent upon the technology used to detect the differential DNA methylation state. For example, in the GSHR example shown in FIG. 6, a threshold of >1.3 (hatched line in figure) would adjust the specificity relative to blood to 100%.
Example 7
Validation of Selected DNA Methylation Biomarkers in a Panel Including Approximately 100 Breast Tumor Samples and 100 Normal Breast Samples
[0176] A panel of 16 biomarker loci was further validated in additional breast tumor and normal breast samples. In total, approximately 100 samples were analyzed for each group. The total number of samples analyzed for each biomarker and for each sample category is reported in Table 5.
TABLE-US-00005 TABLE 5 Sensitivity and specificity of differentially methylated loci in a panel of approximately 100 breast tumor samples, 100 normal breast samples and 25 normal blood samples. No. % No. % No. Positive Total Specficity Positive Total Specficity Locus Positive Total % Normal Normal (Normal Normal Normal (Normal Feature ID Number Tumor Tumor Sensitivity Breast Breast Breast) Blood Blood Blood) ha1p_39189 2 87 102 85% 1 103 99% 1 24 96% ha1g_00644 3 74 101 73% 1 104 99% 0 25 100% ha1p_81674 4 71 99 72% 10 93 89% 1 19 95% ha1p_101251 37 67 101 66% 4 102 96% 2 24 92% ha1p_74707 34 55 102 54% 1 104 99% 0 25 100% ha1g_02416 15 41 101 41% 1 104 99% 0 25 100% ha1p_67625 30 36 91 40% 1 99 99% 0 21 100% ha1p_69407 21 37 100 37% 6 103 94% 1 23 96% ha1p_104423 12 36 98 37% 0 97 100% 1 24 96% ha1p_36172 25 34 102 33% 0 104 100% 0 23 100% ha1p_89799 18 27 101 27% 0 99 100% 0 24 100% ha1p_80771 20 27 103 26% 0 104 100% 0 25 100% ha1p_70459 26 26 101 26% 0 103 100% 1 24 96% ha1p_110107 17 24 101 24% 0 104 100% 0 24 100% ha1p_05406 22 23 103 22% 0 103 100% 0 24 100% ha1g_02345 24 17 102 17% 0 103 100% 0 22 100% No. Positive Tumor: Number of tumor samples that reported avg. dCt ≧ 1.0 (methylated locus). Total Tumor: Number of tumor samples tested. % Sensitivity: (No. Positive Tumor/Total Tumor) × 100 No. Positive Normal Breast: Number of normal breast samples that reported avg. dCt ≧ 1.0 (methylated locus). Total Normal Breast: Number of normal breast samples tested. % Specificity (Nomral Breast): (1 - (No. Positive Nomral Breast/Total Normal Breast)) × 100 No. Posivite Normal Blood: Number of normal blood samples that reported avg. dCt ≧ 1.0 (methylated locus). Total Normal Blood: Number of normal blood samples tested. % Specificity (Normal Blood): (1 - (No. Positive Normal Blood/Total Normal Blood)) × 100
Example 8
Bisulfite Sequencing Confirmation of Differential DNA Methylation
[0177] An example of confirmation of differential DNA methylation by bisulfite sequencing is shown in FIG. 7. Primers were designed to amplify a 130 bp amplicon within the 412 bp region of Nuclear Factor 1X-type analyzed by qPCR (as discussed in the Examples above) from bisulfite converted genomic DNA. Primers sequences lack CpG dinucleotides, and therefore amplify bisulfite converted DNA independently of DNA methylation status. Products were amplified from one tumor sample (positive for DNA methylation) and from one pooled normal female peripheral blood sample. Amplicons were purified and cloned using TA cloning kits (Invitrogen). Eighteen (18) independent clones were sequenced for the tumor sample. Seven (7) independent clones were sequenced for the blood sample. Bisulfite treatment results in conversion of unmethylated cytosines to uracil, but does not convert methylated cytosines. The percent methylation of each CpG dinucleotide within the region was calculated as the number of sequence reads of C at each CpG divided by the total number of sequence reads. FIG. 7A shows the % methylation occupancy for each of the 18 CpG dinucleotides in the tumor sample. FIG. 7B shows the % methylation occupancy for each of the 18 CpG dinucleotides in the normal blood sample. All 18 CpG dinucleotides are methylated in the tumor (occupany ranging from 11% to 89%). However, only one CpG dinucleotide displayed methylation in the normal blood sample (14%).
[0178] To provide further confirmation of DNA methylation differences and to justify the qPCR based strategy for high-throughput detection of DNA methylation, three loci were analyzed by bisulfite genomic sequencing. Primers were designed to amplify approximately 150 bp amplicons within the region of three loci that were analyzed by qPCR as described above. The loci included feature ID ha1p--39189 (locus number 2), ha1g--00644 (locus number 3) and ha1p--104423 (locus number 12). Primer sequences lacked CpG dinucleotides, and therefore amplify bisulfite converted DNA independently of DNA methylation status. For each amplicon, products were amplified from three normal breast DNA samples that reported average dCt values <0.5, three normal breast DNA samples that reported average dCt values between 0.5 and 1.0, and three breast tumor DNA samples that reported average dCt values greater than 1.0. Amplicons were purified and cloned using TA cloning kits (Invitrogen). At least 29 independent clones were sequenced per amplicon, per locus. FIG. 8 shows the median 5-methylcytosine content for all sequenced clones per amplicon plotted against the average dCt value for that locus in the same DNA sample. The dashed vertical line represents the dCt=1.0 threshold used to indicate a positive qPCR measurement for DNA methylation detection. These data verify the differential DNA methylation content in tumors relative to normal breast samples. Furthermore, the linear relationship between the qPCR measurement and the 5-methylcytosine content determined by bisulfate sequencing (R2=0.7965) provides justification for the high-throughput qPCR method for DNA methylation detection.
Example 9
Selection of Sequence Identified as Potential Region of Differential DNA Methylation
[0179] As described in the examples above, the loci identified as differentially methylated were originally discovered based on DNA methylation-dependent microarray analyses. The sequences of the 53 microarray features reporting this differential methylation are indicated in Table 2 and in the "SEQUENCE LISTING" section. Because the "wingspan" of genomic interrogation by each feature is conservatively 1 kb, PCR primers that amplify an amplicon within a 1 kb region surrounding the sequence represented by each microarray feature were selected and used for independent verification and validation experiments. Primer sequences and amplicon sequences are indicated in Table 2 and in the "SEQUENCE LISTING" section. To optimize successful PCR amplification, these amplicons were designed to be less than the entire 1 kb region represented by the wingspan of the microarray feature. However, it should be noted that differential methylation may be detectable anywhere within this sequence window. For each locus, the sequence representing at least this 1 kb region flanking the sequence represented by the microarray feature was selected as the claimed potentially differentially methylated genomic region. These sequences are indicated in Table 2 (DNA Region Sequences) and in the "SEQUENCE LISTING" section. Sequences claimed based on the 1 Kb region flanking the sequence represented by the microarray feature are indicated by "1 kb" in Table 2 (Selection Criteria).
[0180] In addition, the local CpG density surrounding each region was calculated. Approximately 10 kb of sequence both upstream and downstream of each feature was extracted from the human genome. For each 20 kb region of the genome, a sliding window of 500 bp moving in 100 bp steps was used to calculate the CG density. CG density was expressed as the ratio of CG dinucleotides per kb. An example is shown in FIG. 9 and illustrates the position of the transcription start site of the GHSR gene relative to the regional CpG density of the surrounding sequence. In this example, methylation anywhere with the ˜4 kb peak of CpG density associated with the promoter region of the gene is monitored and is useful in a clinical diagnostic assay. Loci in which the claimed region was determined by analysis of local CpG density are indicated by "CG" in Table 2 (Selection Criteria). As diagrammed in FIG. 9, the claimed sequences were selected based on setting the local minimum of CpG density flanking the sequence represented by the PCR amplicon as the upstream and downstream boundaries.
Example 10
Demonstration that Differential DNA Methylation is Detectable in Early Stage Disease
[0181] Although fewer Stage I tumors compared to Stage 11 or III tumors were analyzed (8 of 103 samples), the inclusion of a small number of Stage I tumors allowed a determination of whether the differential methylation events are related to tumor stage. FIG. 10A shows a plot of the frequency of hypermethylation of the 16 loci in the 8 Stage I tumors (i.e. the percentage of Stage I tumors scoring as intermediately to densely methylated) versus the Stage II and III tumors. The relationship between the two sensitivity calculations (R2=0.887; slope=0.9815) indicates that the frequency of hypermethylation of these loci is similar regardless of tumor stage. Therefore, for the majority of loci, the differential methylation events are just as likely to be present in a Stage I tumor as they are in later stage tumors. The proportion of methylated loci in tumors at each stage was then analyzed for three selected loci. The percent depletion by McrBC for each sample in which a given locus scored as methylated was calculated [1-(1/2 delta Ct (McrBC digested-Mock treated))* 100] to provide a measure of the load of methylated molecules within the sample. The mean percent depletion at each tumor stage is shown in FIG. 10B. While there is a trend for increased methylation density at these loci with increasing tumor stage, methylation density of Stage I tumors is not significantly different than Stage II-III tumors, yet is dramatically different than the average of all normal samples. Therefore, differential methylation of these loci is independent of tumor stage in regards to both the frequency and the density of hypermethylation.
Example 11
Receiver-Operator Curve Analysis of Biomarker Sensitivity and Specificity
[0182] Receiver-operator characteristic (ROC) analyses were performed for each of the 16 loci described in Table 5 to determine optimal thresholds for calculation of sensitivity and specificity of the differential DNA methylation event. Examples of the primary qPCR data for four selected loci are shown in FIG. 11A. These plots demonstrate the overall discrimination between tumor, normal breast tissue and normal peripheral blood samples. The frequency at which tumor tissues were scored as differentially methylated at these loci was not significantly associated with either age of the cancer patient or estrogen receptor status of the patient's primary tumor. ROC curves for the corresponding four datasets are shown in FIG. 11B. Optimal thresholds were identified as the maximum sum of sensitivity and specificity calculated at each observed delta Ct value. The minimum allowed threshold was set at 0.5 so that calculations could not be based on thresholds within the variability range of the qPCR platform. Results are summarized in Table 6. Sensitivity and specificity calculations based on optimal thresholds are similar to those calculated using a standard delta Ct threshold of 1.0. As hypothesized, the direct global profiling of DNA methylation identified numerous novel DNA methylation-based biomarkers that display substantially improved sensitivity and specificity relative to the vast majority of previously identified differentially methylated genes in breast cancer. In fact, a single differentially methylated biomarker, located in the promoter region of GHSR, was capable of distinguishing IDC from normal and benign breast tissue with sensitivity of 90% and specificity of 96%. Other biomarkers displayed similar specificity, with decreasing sensitivity. Several of these biomarkers were hypermethylated at a higher frequency than the majority of previously reported hypermethylated biomarkers (i.e. 12 of 16 displayed sensitivity between 53% and 90%).
TABLE-US-00006 TABLE 6 Breast Cancer Biomarker Validation. BREAST TUMOR VS. Locus BREAST TUMOR VS. NORMAL BREAST NORMAL BLOOD Feature ID Number Sensitivity Pos. of Total Specificity Neg. of Total Threshold Specificity Neg. of Total Threshold ha1p_39189 2 90% 92 of 102 96% 99 of 103 0.64 100% 24 of 24 1.22 ha1g_00644 3 89% 90 of 101 92% 96 of 104 0.555 100% 25 of 25 0.695 ha1p_101251 37 77% 78 of 101 87% 89 of 102 0.755 96% 23 of 24 1.06 ha1p_81674 4 70% 69 of 99 92% 86 of 93 1.11 95% 18 of 19 0.935 ha1p_74707 34 69% 69 of 100 82% 84 of 103 0.615 87% 20 of 23 0.63 ha1g_02416 15 65% 66 of 102 97% 101 of 104 0.705 100% 25 of 25 0.535 ha1p_70459 26 63% 64 of 101 97% 101 of 104 0.525 100% 25 of 25 0.57 ha1p_69407 21 63% 64 of 101 93% 96 of 103 0.5 71% 17 of 24 0.55 ha1p_110107 17 60% 61 of 101 98% 102 of 104 0.51 96% 23 of 24 0.51 ha1p_36172 25 58% 59 of 102 100% 104 of 104 0.515 100% 23 of 23 0.515 ha1p_67625 30 56% 51 of 91 97% 96 of 99 0.545 95% 20 of 21 0.545 ha1p_104423 12 53% 52 of 98 97% 94 of 97 0.61 96% 23 of 24 0.855 ha1p_05406 22 48% 49 of 103 97% 100 of 103 0.51 100% 24 of 24 0.51 ha1p_89799 18 42% 42 of 101 99% 98 of 99 0.545 100% 24 of 24 0.71 ha1p_80771 20 38% 39 of 103 97% 101 of 104 0.5 100% 25 of 25 0.72 ha1g_02345 24 34% 35 of 102 97% 100 of 103 0.535 100% 22 of 22 0.535 Thresholds indicate the optimal average dCt value for distinction between tumor and non-tumor tissues.
Example 12
In-Depth Analysis of DNA Methylation by Bisulfite Sequencing
[0183] To provide an in-depth analysis of DNA methylation states relative to the qPCR-based measurements of methylated DNA load between different tissue types, we selected four loci (Locus Number 2, 3, 4 and 12) for extensive bisulfite sequencing analysis (FIG. 12). For each locus, analyzed regions overlapped those amplified in the qPCR assay. Primer pairs were designed to flank, but not include CpG dinucleotides. For analysis of each locus, we selected tumor samples that scored as intermediately to densely methylated and normal breast samples that scored as sparsely methylated. In addition, we selected three histology normal tumor-adjacent tissue samples. Loci were amplified from bisulfite-modified genomic DNA with primers that included patient-specific sequence tags to identify the tissue sample, and amplicons were pooled and sequenced. The average number of molecules analyzed for each locus in each sample was 587. To provide a general measurement of local DNA methylation density at each locus, the total number of CpG sites sequenced as C (methylated) was divided by the total of number of CpG sites sequenced for each individual sample. This percent methylated CpG value was then plotted against the qPCR methylation measurement for the same tissue sample (FIGS. 12A, C, E, G). Methylation load values obtained by bisulfite sequencing and by qPCR displayed a strong correlation for Locus number 2, 12 and 3 (R2=0.76, 0.87 and 0.78, respectively). While tumor samples displayed higher DNA methylation load at Locus number 4 than normal breast and adjacent histology normal breast samples, the non-tumor tissues displayed higher baseline DNA methylation densities than at the other loci (FIG. 12E). Next, the average occurrence of DNA methylation per CpG site in each tissue type was calculated (FIGS. 12B, D, F, H). In general, tumor samples displayed higher variability in methylation per CpG site than non-tumor (i.e., normal) samples (indicated by higher standard deviations for the average percent methylated CpGs). At each locus, the DNA methylation pattern was significantly hypermethylated relative to non-tumor samples. Furthermore, analysis of DNA methylation per CpG site provided an explanation for the higher baseline DNA methylation densities detected at the Locus Number 4 (FIG. 12F). In non-tumor samples, methylation densities at the first three CpG dinucleotides of the analyzed region were greater than 50%, while methylation of the following four CpG dinucleotides fell to lower densities more consistent with the baseline levels of methylation at the other analyzed loci. Interestingly, tumor samples displayed the same general methylation density pattern, but with significantly higher methylation density per CpG across the entire analyzed region. Together, these results confirm the hypermethylated state of these loci in breast cancer and provide an extensive validation of the accuracy of the qPCR-based method used to screen for DNA methylation changes in this study.
Example 13
DNA Hypermethylation is Associated with Decreased Transcription
[0184] To address the association between hypermethylation and transcription repression, we performed RT-PCR analyses of Locus Numbers 2, 4 and 12 (FIG. 13). Four breast infiltrating ductal carcinoma samples (>90% neoplastic cellularity) were analyzed for both DNA methylation and transcription of the three genes. DNA methylation was analyzed using the qPCR-based assays described above. For gene expression analyses, RT-PCR was performed using gene-specific primer pairs designed to flank intronic sequences so that the contribution of contaminating genomic DNA could be excluded. Analysis of GAPDH expression was performed as an internal control. Serial dilutions of first-strand cDNA preparations from tumor samples and a normal breast tissue sample were used as templates for PCR. As shown in FIG. 13, expression of Locus Number 2 transcript (GHSR) was undetectable in all four tumor samples, while expression was detected at 1:10 dilution of the normal breast cDNA. Consistent with the high sensitivity of hypermethylation at the GHSR locus (90%), all tumor samples demonstrated intermediate to dense DNA methylation at this locus. Likewise, all tumor samples displayed reduced expression of Locus Number 12 (NFX1) relative to normal breast tissue. Expression was undetectable in three of four tumor samples, whereas expression was detected in one tumor using undiluted cDNA as template. In normal breast tissue, expression was detected at 1:10 dilution of the cDNA. Interestingly, the tumor sample in which NFX1 expression was detected was scored as sparsely methylated by the qPCR-based assay. Methylation of the analyzed region of Locus Number 4 (MGA) was detected in all four tumors. However, reduced expression of MGA relative to normal breast was demonstrated in two of the four tumor samples.
Example 14
Detection of Tumor-Specific DNA Methylation in Fine Needle Aspirate Specimens
[0185] A common procedure to biopsy suspect masses in the breast is to perform fine needle aspiratation (FNA) of the tissue. The procedure involves removal of a small amount of fluid and cellular material from the suspect mass using a fine gauge needle. In addition, random periareolar fine needle aspiration (RPFNA) can be used to sample breast tissue in asymptomatic women to assess the risk of breast cancer development. Both approaches typically involve a cytological based diagnosis. Therefore, applying molecular tests to specimens obtained by these approaches promises to offer significantly improved clinical sensitivity and specificity relative to the current practice. To assess the ability to detect breast tumor-specific DNA methylation of the claimed differentially methylated loci, eight loci with varying frequency of differential DNA methylation in primary breast tissue were analyzed in a panel of 7 FNA specimens taken from women with confirmed infiltrating ductal breast carcinoma. DNA methylation was measured as described in Example 3. These included Locus Number 1, 2, 3, 4, 12, 37, 38 and 43. In FIG. 14, the percent sensitivity for each locus as listed in Tables 3A and 3B (i.e. the percentage of tumors that report and average dCt >1.0) is plotted against the percentage of unmatched FNA samples that report and average dCt>1.0. The frequency of DNA methylation detection (i.e. samples that report an average dCt>1.0) is very similar regardless of whether primary tumor samples or unmatched FNA specimens from confirmed breast cancer patients were analyzed (R2=0.7415, slope=0.817). These results suggest that the DNA methylation biomarkers described herein can be detected in a sample type relevant to molecular diagnostics of breast cancer.
Example 15
Analysis of DNA Methylation in Various Cancer Types
[0186] To address the applicability of the claimed DNA methylation biomarkers to cancer types other than breast cancer, all 53 claimed biomarkers were analyzed in panels of lung, renal, liver, ovarian, head and neck, thyroid, bladder, cervical, colon, endometrial, esophageal and prostate tumors. Adjacent histology normal tissues were analyzed as controls. In addition, melanoma tumors were analyzed, although no adjacent normal tissues were available. The number of samples analyzed for each cancer type is provided in Table 7. DNA methylation was measured as described in Example 3. For each locus and each cancer type, the sensitivity and specificity for discriminating between tumor and adjacent normal tissue are reported in Tables 8-20. For melanoma tumors (Table 20), only sensitivity (the frequency of DNA methylation detection (i.e. samples that report an average dCt≧1.0)) is reported due to the unavailability of adjacent normal tissues. For each locus, the optimal threshold for discriminating between tumor and adjacent normal tissue was calculated following ROC curve analyses as described in Example 11. These data demonstrate that particular biomarker loci are applicable to cancer types other than breast cancer.
TABLE-US-00007 TABLE 7 Number of Tumor and Adjacent Normal tissues tested for methylation of the 53 biomarker loci. Cancer Type Tumor Adjacent Normal Lung 10 10 Renal 10 10 Liver 9 9 Ovarian 8 8 Head and Neck 9 5 Thyroid 9 9 Bladder 9 9 Cervical 10 9 Colon 8 8 Endometrial 14 9 Esophageal 9 10 Prostate 9 9 Melanoma 7 0
TABLE-US-00008 TABLE 8 Sensitivity and Specificity of differentially methylated loci in lung tumors relative to adjacent histological normal lung tissue. Pos. Neg. Feature Locus Thresh- Sensi- of Speci- of ID Number old tivity Total ficity Total ha1p_105474 33 1.98 80% 8 of 10 100% 10 of 10 ha1p_39189 2 1.17 70% 7 of 10 100% 10 of 10 ha1p_23178 9 3.015 70% 7 of 10 100% 10 of 10 ha1p_89099 28 1.38 70% 7 of 10 100% 10 of 10 ha1g_00644 3 1.445 60% 6 of 10 100% 10 of 10 ha1p_40164 8 1.96 60% 3 of 5 100% 5 of 5 ha1p_81149 5 2.37 50% 5 of 10 100% 10 of 10 ha1p_08347 14 1.67 50% 4 of 8 100% 7 of 7 ha1p_12075 46 2.33 43% 3 of 7 100% 7 of 7 ha1p_40959 11 2.435 40% 4 of 10 100% 10 of 10 ha1p_36172 25 0.835 40% 4 of 10 100% 10 of 10 ha1p_56412 44 3.86 40% 4 of 10 100% 9 of 9 ha1g_03099 29 0.635 30% 3 of 10 100% 10 of 10 ha1p_67625 30 0.965 30% 3 of 10 100% 9 of 9 ha1p_93325 35 2.93 30% 3 of 10 100% 10 of 10 ha1p_103824 40 0.765 30% 3 of 10 100% 10 of 10 ha1p_69407 21 2.77 29% 2 of 7 100% 6 of 6 ha1p_81674 4 2.165 25% 2 of 8 100% 7 of 7 ha1p_80771 20 1.05 20% 2 of 10 100% 9 of 9 ha1g_00218 31 0.71 10% 1 of 10 100% 10 of 10 ha1p_45173 19 1.66 100% 10 of 10 90% 9 of 10 ha1p_83841 6 1.54 90% 9 of 10 90% 9 of 10 ha1p_46057 10 0.9 90% 9 of 10 90% 9 of 10 ha1p_105937 27 1.375 80% 8 of 10 90% 9 of 10 ha1p_69214 38 3.735 78% 7 of 9 90% 9 of 10 ha1p_18292 45 2.06 60% 6 of 10 90% 9 of 10 ha1p_12535 32 2.05 50% 5 of 10 90% 9 of 10 ha1p_67002 51 2.025 50% 5 of 10 90% 9 of 10 ha1p_87540 16 0.98 80% 8 of 10 89% 8 of 9 ha1p_108445 41 1.9 40% 4 of 10 89% 8 of 9 ha1p_88517 39 1.38 50% 3 of 6 83% 5 of 6 ha1p_29531 48 1.01 90% 9 of 10 80% 8 of 10 ha1p_58853 49 1.315 80% 8 of 10 80% 8 of 10 ha1p_103872 43 2.96 70% 7 of 10 80% 8 of 10 ha1p_89799 18 0.5 63% 5 of 8 80% 8 of 10 ha1p_104423 12 0.83 40% 4 of 10 80% 8 of 10 ha1p_80287 23 0.82 40% 4 of 10 80% 8 of 10 ha1p_74707 34 0.76 78% 7 of 9 78% 7 of 9 ha1p_38705 7 0.62 63% 5 of 8 78% 7 of 9 ha1g_00681 1 1.965 56% 5 of 9 78% 7 of 9 ha1p_35052 50 1.6 70% 7 of 10 70% 7 of 10 ha1p_45580 52 3.1 70% 7 of 10 70% 7 of 10 ha1g_02345 24 0.51 67% 6 of 9 67% 6 of 9 ha1p_05406 22 0.615 71% 5 of 7 63% 5 of 8 ha1p_22519 47 1.6 100% 10 of 10 60% 6 of 10 ha1g_02416 15 0.58 90% 9 of 10 60% 6 of 10 ha1p_101161 36 0.885 80% 8 of 10 60% 6 of 10 ha1g_00847 13 0.53 63% 5 of 8 60% 6 of 10 ha1g_02210 42 0.605 60% 6 of 10 60% 6 of 10 ha1p_70459 26 0.54 100% 6 of 6 56% 5 of 9 ha1p_12646 53 5.455 78% 7 of 9 56% 5 of 9 ha1p_101251 37 1.34 100% 10 of 10 40% 4 of 10 ha1p_110107 17 0.55 86% 6 of 7 40% 4 of 10 Threshold: Average dCt value established by ROC curve analysis as optimal threshold for distinguishing tumor and adjacent normal tissues. Sensitivity: % of positive (i.e. methylation score above Threshold) tumors. Pos. of Total: Number of positive tumors relative to the total number of tumors analyzed. Specificity: % of negative (i.e. methylation score below Threshold) adjacent normal samples. Neg. of Total: Number of negative adjacent normal samples relative to the total number of adjacent normal samples analyzed.
TABLE-US-00009 TABLE 9 Sensitivity and Specificity of differentially methylated loci in renal tumors relative to adjacent histological normal kidney tissue. Pos. Neg. Feature Locus Thresh- Sensi- of Speci- of ID Number old tivity Total ficity Total ha1p_29531 48 0.68 80% 8 of 10 100% 10 of 10 ha1p_23178 9 1.52 70% 7 of 10 100% 10 of 10 ha1p_69407 21 1.255 70% 7 of 10 100% 10 of 10 ha1p_22519 47 1.68 67% 6 of 9 100% 10 of 10 ha1g_00644 3 1.135 60% 6 of 10 100% 10 of 10 ha1p_83841 6 1.2 60% 6 of 10 100% 9 of 9 ha1p_80771 20 0.535 60% 6 of 10 100% 10 of 10 ha1p_103872 43 3.25 60% 6 of 10 100% 10 of 10 ha1p_89099 28 0.935 56% 5 of 9 100% 9 of 9 ha1p_74707 34 1.6 56% 5 of 9 100% 10 of 10 ha1g_02416 15 0.56 50% 5 of 10 100% 9 of 9 ha1p_45173 19 0.675 50% 5 of 10 100% 10 of 10 ha1p_105937 27 0.99 50% 5 of 10 100% 10 of 10 ha1p_93325 35 1.155 50% 5 of 10 100% 10 of 10 ha1p_108445 41 1.025 50% 5 of 10 100% 10 of 10 ha1p_103824 40 0.82 44% 4 of 9 100% 10 of 10 ha1p_56412 44 1.84 44% 4 of 9 100% 10 of 10 ha1p_38705 7 1.28 40% 4 of 10 100% 9 of 9 ha1p_70459 26 0.74 40% 4 of 10 100% 9 of 9 ha1p_36172 25 0.92 33% 3 of 9 100% 10 of 10 ha1g_02345 24 0.565 30% 3 of 10 100% 10 of 10 ha1p_80287 23 1.135 22% 2 of 9 100% 10 of 10 ha1g_03099 29 0.555 20% 2 of 10 100% 10 of 10 ha1p_58853 49 1.195 11% 1 of 9 100% 10 of 10 ha1p_08347 14 2.65 100% 9 of 9 90% 9 of 10 ha1p_46057 10 1.325 80% 8 of 10 90% 9 of 10 ha1g_00681 1 1.905 60% 6 of 10 90% 9 of 10 ha1p_18292 45 1.09 60% 6 of 10 90% 9 of 10 ha1p_87540 16 0.925 40% 4 of 10 90% 9 of 10 ha1p_89799 18 0.605 40% 4 of 10 90% 9 of 10 ha1p_05406 22 0.52 40% 4 of 10 90% 9 of 10 ha1g_00218 31 0.505 20% 2 of 10 90% 9 of 10 ha1p_39189 2 1.03 80% 8 of 10 89% 8 of 9 ha1p_67625 30 0.79 60% 6 of 10 89% 8 of 9 ha1p_88517 39 1.98 50% 5 of 10 89% 8 of 9 ha1p_35052 50 1.495 100% 10 of 10 80% 8 of 10 ha1p_40164 8 0.825 90% 9 of 10 80% 8 of 10 ha1p_67002 51 1.565 90% 9 of 10 80% 8 of 10 ha1p_40959 11 0.88 80% 8 of 10 80% 8 of 10 ha1p_12535 32 0.93 70% 7 of 10 80% 8 of 10 ha1p_12646 53 4.23 60% 6 of 10 80% 8 of 10 ha1p_110107 17 0.53 56% 5 of 9 80% 8 of 10 ha1p_101161 36 0.93 40% 4 of 10 80% 8 of 10 ha1g_02210 42 0.52 33% 3 of 9 80% 8 of 10 ha1g_00847 13 0.7 56% 5 of 9 78% 7 of 9 ha1p_81674 4 1.365 89% 8 of 9 67% 6 of 9 ha1p_12075 46 1.66 89% 8 of 9 56% 5 of 9 ha1p_45580 52 2.1 100% 10 of 10 50% 5 of 10 ha1p_81149 5 0.875 90% 9 of 10 50% 5 of 10 ha1p_105474 33 1.035 70% 7 of 10 50% 5 of 10 ha1p_101251 37 1 70% 7 of 10 50% 5 of 10 ha1p_104423 12 0.68 80% 8 of 10 40% 4 of 10 ha1p_69214 38 1.085 100% 10 of 10 33% 3 of 9 Threshold: Average dCt value established by ROC curve analysis as optimal threshold for distinguishing tumor and adjacent normal tissues. Sensitivity: % of positive (i.e. methylation score above Threshold) tumors. Pos. of Total: Number of positive tumors relative to the total number of tumors analyzed. Specificity: % of negative (i.e. methylation score below Threshold) adjacent normal samples. Neg. of Total: Number of negative adjacent normal samples relative to the total number of adjacent normal samples analyzed.
TABLE-US-00010 TABLE 10 Sensitivity and Specificity of differentially methylated loci in liver tumors relative to adjacent histological normal liver tissue. Pos. Neg. Feature Locus Thresh- Sensi- of Speci- of ID Number old tivity Total ficity Total ha1p_89799 18 3.01 67% 6 of 9 100% 9 of 9 ha1p_81674 4 1.66 56% 5 of 9 100% 9 of 9 ha1p_56412 44 1.94 56% 5 of 9 100% 9 of 9 ha1p_67002 51 1.825 50% 4 of 8 100% 9 of 9 ha1p_81149 5 1.39 38% 3 of 8 100% 9 of 9 ha1p_83841 6 1.305 38% 3 of 8 100% 9 of 9 ha1p_74707 34 1.335 38% 3 of 8 100% 8 of 8 ha1p_80771 20 0.87 33% 3 of 9 100% 9 of 9 ha1p_70459 26 2.785 33% 3 of 9 100% 9 of 9 ha1p_89099 28 2.715 33% 3 of 9 100% 8 of 8 ha1p_12535 32 2.1 33% 3 of 9 100% 9 of 9 ha1p_39189 2 4.805 25% 2 of 8 100% 9 of 9 ha1g_00218 31 0.775 22% 2 of 9 100% 9 of 9 ha1p_12646 53 3.49 17% 1 of 6 100% 7 of 7 ha1g_00847 13 0.86 78% 7 of 9 89% 8 of 9 ha1p_05406 22 1.465 78% 7 of 9 89% 8 of 9 ha1p_105474 33 1.55 78% 7 of 9 89% 8 of 9 ha1p_69407 21 3.06 67% 6 of 9 89% 8 of 9 ha1g_02416 15 0.94 50% 4 of 8 89% 8 of 9 ha1p_40164 8 1.91 44% 4 of 9 89% 8 of 9 ha1p_101251 37 1.195 44% 4 of 9 89% 8 of 9 ha1p_110107 17 1.955 38% 3 of 8 89% 8 of 9 ha1p_105937 27 1.585 38% 3 of 8 89% 8 of 9 ha1p_18292 45 2.51 63% 5 of 8 88% 7 of 8 ha1p_35052 50 6 89% 8 of 9 78% 7 of 9 ha1p_67625 30 1.97 83% 5 of 6 78% 7 of 9 ha1p_23178 9 2.655 78% 7 of 9 78% 7 of 9 ha1p_93325 35 4.85 78% 7 of 9 78% 7 of 9 ha1g_00681 1 0.615 75% 6 of 8 78% 7 of 9 ha1p_22519 47 1.975 71% 5 of 7 78% 7 of 9 ha1p_38705 7 2.51 67% 6 of 9 78% 7 of 9 ha1p_08347 14 1.08 67% 6 of 9 78% 7 of 9 ha1p_101161 36 1.07 67% 6 of 9 78% 7 of 9 ha1p_69214 38 3.31 67% 6 of 9 78% 7 of 9 ha1g_02345 24 0.695 63% 5 of 8 78% 7 of 9 ha1p_87540 16 1.45 56% 5 of 9 78% 7 of 9 ha1p_45173 19 4.58 56% 5 of 9 78% 7 of 9 ha1p_88517 39 1.86 44% 4 of 9 78% 7 of 9 ha1g_00644 3 0.545 22% 2 of 9 78% 7 of 9 ha1p_103824 40 1.045 75% 6 of 8 75% 6 of 8 ha1p_108445 41 1.595 67% 4 of 6 75% 6 of 8 ha1p_45580 52 2.055 63% 5 of 8 75% 6 of 8 ha1p_80287 23 3.75 83% 5 of 6 71% 5 of 7 ha1p_46057 10 1.685 67% 6 of 9 67% 6 of 9 ha1p_36172 25 2.95 67% 6 of 9 67% 6 of 9 ha1g_02210 42 0.52 67% 6 of 9 67% 6 of 9 ha1p_12075 46 1.725 67% 6 of 9 67% 6 of 9 ha1p_29531 48 3.385 67% 6 of 9 67% 6 of 9 ha1p_58853 49 1.905 63% 5 of 8 67% 6 of 9 ha1p_103872 43 1.02 56% 5 of 9 67% 6 of 9 ha1g_03099 29 0.68 67% 6 of 9 56% 5 of 9 ha1p_104423 12 0.845 100% 7 of 7 43% 3 of 7 ha1p_40959 11 3.51 75% 6 of 8 33% 3 of 9 Threshold: Average dCt value established by ROC curve analysis as optimal threshold for distinguishing tumor and adjacent normal tissues. Sensitivity: % of positive (i.e. methylation score above Threshold) tumors. Pos. of Total: Number of positive tumors relative to the total number of tumors analyzed. Specificity: % of negative (i.e. methylation score below Threshold) adjacent normal samples. Neg. of Total: Number of negative adjacent normal samples relative to the total number of adjacent normal samples analyzed.
TABLE-US-00011 TABLE 11 Sensitivity and Specificity of differentially methylated loci in ovarian tumors relative to adjacent histological normal ovary tissue. Pos. Neg. Feature Locus Thresh- Sensi- of Speci- of ID Number old tivity Total ficity Total ha1g_00644 3 0.535 100% 7 of 7 100% 8 of 8 ha1p_46057 10 0.6 100% 8 of 8 100% 8 of 8 ha1p_81674 4 1.47 88% 7 of 8 100% 8 of 8 ha1p_81149 5 1.335 88% 7 of 8 100% 8 of 8 ha1g_00847 13 0.69 88% 7 of 8 100% 8 of 8 ha1p_12535 32 0.695 88% 7 of 8 100% 8 of 8 ha1p_69214 38 1.06 88% 7 of 8 100% 7 of 7 ha1p_22519 47 1.395 88% 7 of 8 100% 8 of 8 ha1p_12646 53 0.88 88% 7 of 8 100% 8 of 8 ha1p_38705 7 0.65 80% 4 of 5 100% 5 of 5 ha1g_00681 1 1.01 75% 6 of 8 100% 8 of 8 ha1p_39189 2 0.97 75% 6 of 8 100% 8 of 8 ha1p_83841 6 0.83 75% 6 of 8 100% 7 of 7 ha1p_23178 9 0.655 75% 6 of 8 100% 8 of 8 ha1p_08347 14 1.165 75% 6 of 8 100% 8 of 8 ha1p_45173 19 0.74 75% 6 of 8 100% 8 of 8 ha1p_105474 33 1.115 75% 6 of 8 100% 8 of 8 ha1p_101161 36 0.53 75% 6 of 8 100% 8 of 8 ha1p_103872 43 0.77 75% 6 of 8 100% 8 of 8 ha1p_104423 12 0.54 63% 5 of 8 100% 8 of 8 ha1g_02416 15 0.665 63% 5 of 8 100% 8 of 8 ha1p_05406 22 0.92 63% 5 of 8 100% 8 of 8 ha1p_89099 28 0.575 63% 5 of 8 100% 8 of 8 ha1p_103824 40 0.635 63% 5 of 8 100% 8 of 8 ha1p_12075 46 0.87 63% 5 of 8 100% 8 of 8 ha1p_18292 45 1.335 57% 4 of 7 100% 8 of 8 ha1p_110107 17 0.7 50% 3 of 6 100% 8 of 8 ha1p_67625 30 1.105 50% 4 of 8 100% 8 of 8 ha1p_93325 35 0.505 50% 4 of 8 100% 8 of 8 ha1p_56412 44 1.63 50% 4 of 8 100% 7 of 7 ha1p_58853 49 1.215 50% 4 of 8 100% 8 of 8 ha1p_45580 52 1.6 50% 4 of 8 100% 8 of 8 ha1p_87540 16 0.715 43% 3 of 7 100% 8 of 8 ha1p_89799 18 0.865 43% 3 of 7 100% 7 of 7 ha1p_36172 25 1.235 38% 3 of 8 100% 8 of 8 ha1p_105937 27 0.81 38% 3 of 8 100% 8 of 8 ha1g_03099 29 0.6 38% 3 of 8 100% 8 of 8 ha1p_74707 34 0.665 38% 3 of 8 100% 8 of 8 ha1p_80771 20 0.505 25% 2 of 8 100% 8 of 8 ha1g_00218 31 0.59 25% 2 of 8 100% 8 of 8 ha1p_80287 23 0.675 13% 1 of 8 100% 8 of 8 ha1p_40959 11 0.515 88% 7 of 8 88% 7 of 8 ha1p_69407 21 1.335 75% 6 of 8 88% 7 of 8 ha1p_29531 48 0.865 75% 6 of 8 88% 7 of 8 ha1p_40164 8 0.625 63% 5 of 8 88% 7 of 8 ha1p_108445 41 0.56 63% 5 of 8 88% 7 of 8 ha1p_70459 26 0.605 50% 4 of 8 88% 7 of 8 ha1p_35052 50 1.63 43% 3 of 7 88% 7 of 8 ha1g_02210 42 0.715 38% 3 of 8 88% 7 of 8 ha1g_02345 24 0.525 38% 3 of 8 86% 6 of 7 ha1p_101251 37 1.045 88% 7 of 8 75% 6 of 8 ha1p_67002 51 1.175 63% 5 of 8 75% 6 of 8 ha1p_88517 39 0.59 43% 3 of 7 75% 6 of 8 Threshold: Average dCt value established by ROC curve analysis as optimal threshold for distinguishing tumor and adjacent normal tissues. Sensitivity: % of positive (i.e. methylation score above Threshold) tumors. Pos. of Total: Number of positive tumors relative to the total number of tumors analyzed. Specificity: % of negative (i.e. methylation score below Threshold) adjacent normal samples. Neg. of Total: Number of negative adjacent normal samples relative to the total number of adjacent normal samples analyzed.
TABLE-US-00012 TABLE 12 Sensitivity and Specificity of differentially methylated loci in head and neck tumors relative to adjacent histological normal head and neck tissue. Pos. Neg. Feature Locus Thresh- Sensi- of Speci- of ID Number old tivity Total ficity Total ha1p_108445 41 2.695 89% 8 of 9 100% 5 of 5 ha1p_39189 2 1.035 78% 7 of 9 100% 5 of 5 ha1p_45173 19 1.195 78% 7 of 9 100% 5 of 5 ha1p_08347 14 0.94 67% 6 of 9 100% 5 of 5 ha1p_105474 33 2.15 67% 6 of 9 100% 5 of 5 ha1p_12075 46 0.795 67% 4 of 6 100% 4 of 4 ha1p_12646 53 2.28 67% 6 of 9 100% 5 of 5 ha1p_67625 30 0.505 63% 5 of 8 100% 5 of 5 ha1p_35052 50 1.575 63% 5 of 8 100% 5 of 5 ha1p_23178 9 1.715 56% 5 of 9 100% 5 of 5 ha1p_74707 34 0.76 56% 5 of 9 100% 5 of 5 ha1p_103872 43 2.535 56% 5 of 9 100% 5 of 5 ha1p_18292 45 1.725 56% 5 of 9 100% 4 of 4 ha1p_22519 47 2.27 56% 5 of 9 100% 5 of 5 ha1p_83841 6 1.69 50% 4 of 8 100% 5 of 5 ha1p_81149 5 2.98 44% 4 of 9 100% 5 of 5 ha1p_93325 35 2.145 44% 4 of 9 100% 5 of 5 ha1g_02210 42 1.11 38% 3 of 8 100% 5 of 5 ha1p_58853 49 2.815 38% 3 of 8 100% 5 of 5 ha1p_40959 11 1.42 33% 3 of 9 100% 5 of 5 ha1p_05406 22 0.685 33% 3 of 9 100% 4 of 4 ha1g_02345 24 0.54 33% 3 of 9 100% 5 of 5 ha1p_29531 48 1.465 33% 3 of 9 100% 5 of 5 ha1p_40164 8 1.63 22% 2 of 9 100% 5 of 5 ha1p_110107 17 0.62 22% 2 of 9 100% 5 of 5 ha1g_03099 29 0.68 22% 2 of 9 100% 4 of 4 ha1p_80287 23 1.625 13% 1 of 8 100% 5 of 5 ha1p_36172 25 0.73 11% 1 of 9 100% 5 of 5 ha1p_56412 44 1.53 89% 8 of 9 80% 4 of 5 ha1p_38705 7 0.855 75% 6 of 8 80% 4 of 5 ha1p_105937 27 0.545 67% 6 of 9 80% 4 of 5 ha1p_45580 52 1.315 67% 6 of 9 80% 4 of 5 ha1p_87540 16 0.865 63% 5 of 8 80% 4 of 5 ha1p_46057 10 1.18 56% 5 of 9 80% 4 of 5 ha1p_104423 12 0.675 56% 5 of 9 80% 4 of 5 ha1g_00847 13 1.125 56% 5 of 9 80% 4 of 5 ha1p_70459 26 0.555 56% 5 of 9 80% 4 of 5 ha1p_101161 36 0.765 44% 4 of 9 80% 4 of 5 ha1p_67002 51 1.67 44% 4 of 9 80% 4 of 5 ha1g_02416 15 0.71 38% 3 of 8 80% 4 of 5 ha1p_103824 40 0.525 33% 3 of 9 80% 4 of 5 ha1p_89799 18 0.69 22% 2 of 9 80% 4 of 5 ha1p_80771 20 0.86 11% 1 of 9 80% 4 of 5 ha1p_81674 4 1.15 78% 7 of 9 75% 3 of 4 ha1p_69407 21 1.315 67% 6 of 9 75% 3 of 4 ha1p_89099 28 0.59 67% 6 of 9 75% 3 of 4 ha1p_88517 39 0.985 86% 6 of 7 67% 2 of 3 ha1g_00644 3 0.52 89% 8 of 9 60% 3 of 5 ha1p_12535 32 0.95 78% 7 of 9 60% 3 of 5 ha1p_69214 38 1.39 78% 7 of 9 60% 3 of 5 ha1g_00681 1 1.045 89% 8 of 9 40% 2 of 5 ha1p_101251 37 0.78 67% 6 of 9 40% 2 of 5 ha1g_00218 31 -- -- -- -- -- Threshold: Average dCt value established by ROC curve analysis as optimal threshold for distinguishing tumor and adjacent normal tissues. Sensitivity: % of positive (i.e. methylation score above Threshold) tumors. Pos. of Total: Number of positive tumors relative to the total number of tumors analyzed. Specificity: % of negative (i.e. methylation score below Threshold) adjacent normal samples. Neg. of Total: Number of negative adjacent normal samples relative to the total number of adjacent normal samples analyzed.
TABLE-US-00013 TABLE 13 Sensitivity and Specificity of differentially methylated loci in thyroid tumors relative to adjacent histological normal thyroid tissue. Pos. Neg. Feature Locus Thresh- Sensi- of Speci- of ID Number old tivity Total ficity Total ha1g_02345 24 1.02 86% 6 of 7 100% 8 of 8 ha1g_02210 42 0.745 80% 4 of 5 100% 5 of 5 ha1p_05406 22 0.63 57% 4 of 7 100% 9 of 9 ha1p_88517 39 1.815 50% 4 of 8 100% 5 of 5 ha1p_56412 44 2.98 50% 4 of 8 100% 9 of 9 ha1p_45580 52 3.76 44% 4 of 9 100% 9 of 9 ha1g_02416 15 0.57 43% 3 of 7 100% 9 of 9 ha1p_36172 25 0.515 38% 3 of 8 100% 9 of 9 ha1g_00218 31 0.655 33% 3 of 9 100% 9 of 9 ha1p_105937 27 1.055 22% 2 of 9 100% 9 of 9 ha1g_00847 13 1.35 11% 1 of 9 100% 9 of 9 ha1p_80771 20 1.305 11% 1 of 9 100% 9 of 9 ha1p_80287 23 1.635 11% 1 of 9 100% 9 of 9 ha1g_03099 29 0.76 11% 1 of 9 100% 9 of 9 ha1p_108445 41 0.665 88% 7 of 8 89% 8 of 9 ha1p_89099 28 1.25 78% 7 of 9 89% 8 of 9 ha1p_29531 48 0.825 78% 7 of 9 89% 8 of 9 ha1p_67002 51 1.65 71% 5 of 7 89% 8 of 9 ha1p_39189 2 0.85 67% 6 of 9 89% 8 of 9 ha1g_00644 3 0.62 67% 6 of 9 89% 8 of 9 ha1p_22519 47 2.2 67% 6 of 9 89% 8 of 9 ha1p_38705 7 1.575 63% 5 of 8 89% 8 of 9 ha1p_89799 18 0.775 56% 5 of 9 89% 8 of 9 ha1p_74707 34 0.62 56% 5 of 9 89% 8 of 9 ha1p_93325 35 0.935 56% 5 of 9 89% 8 of 9 ha1p_23178 9 0.77 44% 4 of 9 89% 8 of 9 ha1p_110107 17 0.545 38% 3 of 8 89% 8 of 9 ha1p_101161 36 1.11 33% 3 of 9 89% 8 of 9 ha1p_103824 40 0.57 33% 3 of 9 89% 8 of 9 ha1p_12646 53 4.84 33% 3 of 9 89% 8 of 9 ha1p_81674 4 1.43 75% 6 of 8 88% 7 of 8 ha1p_67625 30 0.57 50% 3 of 6 88% 7 of 8 ha1p_69407 21 2.045 33% 3 of 9 88% 7 of 8 ha1g_00681 1 0.93 89% 8 of 9 78% 7 of 9 ha1p_83841 6 0.67 78% 7 of 9 78% 7 of 9 ha1p_46057 10 1.735 78% 7 of 9 78% 7 of 9 ha1p_40959 11 0.86 78% 7 of 9 78% 7 of 9 ha1p_45173 19 0.96 78% 7 of 9 78% 7 of 9 ha1p_101251 37 1.74 78% 7 of 9 78% 7 of 9 ha1p_58853 49 0.97 78% 7 of 9 78% 7 of 9 ha1p_103872 43 0.83 67% 6 of 9 78% 7 of 9 ha1p_12535 32 1.325 89% 8 of 9 67% 6 of 9 ha1p_12075 46 2.32 67% 6 of 9 67% 6 of 9 ha1p_104423 12 1.07 56% 5 of 9 67% 6 of 9 ha1p_105474 33 2.395 56% 5 of 9 67% 6 of 9 ha1p_08347 14 1.255 100% 9 of 9 56% 5 of 9 ha1p_69214 38 2.315 100% 9 of 9 56% 5 of 9 ha1p_18292 45 0.885 100% 8 of 8 56% 5 of 9 ha1p_81149 5 1.305 89% 8 of 9 56% 5 of 9 ha1p_40164 8 0.51 78% 7 of 9 56% 5 of 9 ha1p_87540 16 1.105 67% 6 of 9 56% 5 of 9 ha1p_35052 50 0.825 89% 8 of 9 44% 4 of 9 ha1p_70459 26 0.58 88% 7 of 8 43% 3 of 7 Threshold: Average dCt value established by ROC curve analysis as optimal threshold for distinguishing tumor and adjacent normal tissues. Sensitivity: % of positive (i.e. methylation score above Threshold) tumors. Pos. of Total: Number of positive tumors relative to the total number of tumors analyzed. Specificity: % of negative (i.e. methylation score below Threshold) adjacent normal samples. Neg. of Total: Number of negative adjacent normal samples relative to the total number of adjacent normal samples analyzed.
TABLE-US-00014 TABLE 14 Sensitivity and Specificity of differentially methylated loci in bladder tumors relative to adjacent histological normal bladder tissue. Pos. Neg. Feature Locus Thresh- Sensi- of Speci- of ID Number old tivity Total ficity Total ha1g_00681 1 0.865 100% 9 of 9 100% 8 of 8 ha1g_00644 3 1.245 100% 9 of 9 100% 9 of 9 ha1p_81674 4 1.895 100% 5 of 5 100% 6 of 6 ha1p_46057 10 1.255 100% 9 of 9 100% 9 of 9 ha1p_45173 19 1.39 100% 8 of 8 100% 9 of 9 ha1g_00847 13 2.315 89% 8 of 9 100% 8 of 8 ha1p_105937 27 0.89 89% 8 of 9 100% 9 of 9 ha1g_03099 29 1.155 89% 8 of 9 100% 7 of 7 ha1p_12535 32 0.745 89% 8 of 9 100% 8 of 8 ha1p_105474 33 0.96 89% 8 of 9 100% 9 of 9 ha1p_101161 36 1.185 89% 8 of 9 100% 9 of 9 ha1p_69214 38 2.12 89% 8 of 9 100% 9 of 9 ha1p_103872 43 1.045 89% 8 of 9 100% 9 of 9 ha1p_38705 7 0.54 88% 7 of 8 100% 9 of 9 ha1p_18292 45 2.025 88% 7 of 8 100% 8 of 8 ha1p_104423 12 1.54 78% 7 of 9 100% 9 of 9 ha1p_08347 14 2.225 78% 7 of 9 100% 8 of 8 ha1p_110107 17 0.995 78% 7 of 9 100% 9 of 9 ha1p_70459 26 2.27 78% 7 of 9 100% 9 of 9 ha1p_74707 34 1.24 78% 7 of 9 100% 9 of 9 ha1p_101251 37 1.655 78% 7 of 9 100% 9 of 9 ha1p_88517 39 3.035 78% 7 of 9 100% 9 of 9 ha1p_29531 48 0.625 78% 7 of 9 100% 9 of 9 ha1p_39189 2 0.525 75% 6 of 8 100% 6 of 6 ha1p_40164 8 1.815 67% 4 of 6 100% 8 of 8 ha1g_02416 15 2.01 67% 6 of 9 100% 8 of 8 ha1p_40959 11 0.54 56% 5 of 9 100% 7 of 7 ha1p_93325 35 1.845 56% 5 of 9 100% 9 of 9 ha1p_22519 47 1.265 56% 5 of 9 100% 9 of 9 ha1p_23178 9 1.66 50% 4 of 8 100% 9 of 9 ha1g_02345 24 0.665 44% 4 of 9 100% 8 of 8 ha1p_45580 52 1.22 22% 2 of 9 100% 8 of 8 ha1p_56412 44 1.725 100% 8 of 8 89% 8 of 9 ha1p_58853 49 1.125 100% 9 of 9 89% 8 of 9 ha1p_83841 6 0.8 89% 8 of 9 89% 8 of 9 ha1p_80771 20 0.67 89% 8 of 9 89% 8 of 9 ha1p_89099 28 1.08 89% 8 of 9 89% 8 of 9 ha1p_103824 40 0.575 89% 8 of 9 89% 8 of 9 ha1p_12075 46 0.705 88% 7 of 8 89% 8 of 9 ha1p_80287 23 0.595 78% 7 of 9 89% 8 of 9 ha1p_36172 25 0.63 75% 6 of 8 89% 8 of 9 ha1p_67625 30 0.765 75% 6 of 8 89% 8 of 9 ha1p_05406 22 2.03 56% 5 of 9 89% 8 of 9 ha1p_67002 51 2.215 56% 5 of 9 89% 8 of 9 ha1p_87540 16 1.395 89% 8 of 9 88% 7 of 8 ha1p_35052 50 0.65 56% 5 of 9 88% 7 of 8 ha1p_89799 18 1.05 89% 8 of 9 78% 7 of 9 ha1g_00218 31 0.83 89% 8 of 9 78% 7 of 9 ha1p_12646 53 0.79 78% 7 of 9 78% 7 of 9 ha1g_02210 42 1.145 60% 3 of 5 78% 7 of 9 ha1p_108445 41 1.99 100% 9 of 9 75% 6 of 8 ha1p_81149 5 0.615 100% 8 of 8 67% 6 of 9 ha1p_69407 21 1.185 100% 9 of 9 67% 6 of 9 Threshold: Average dCt value established by ROC curve analysis as optimal threshold for distinguishing tumor and adjacent normal tissues. Sensitivity: % of positive (i.e. methylation score above Threshold) tumors. Pos. of Total: Number of positive tumors relative to the total number of tumors analyzed. Specificity: % of negative (i.e. methylation score below Threshold) adjacent normal samples. Neg. of Total: Number of negative adjacent normal samples relative to the total number of adjacent normal samples analyzed.
TABLE-US-00015 TABLE 15 Sensitivity and Specificity of differentially methylated loci in cervical tumors relative to adjacent histological normal cervical tissue. Pos. Neg. Feature Locus Thresh- Sensi- of Speci- of ID Number old tivity Total ficity Total ha1p_83841 6 0.905 100% 9 of 9 100% 8 of 8 ha1p_23178 9 1 100% 9 of 9 100% 9 of 9 ha1p_74707 34 0.61 100% 9 of 9 100% 9 of 9 ha1p_108445 41 0.995 100% 10 of 10 100% 9 of 9 ha1p_40959 11 1.49 90% 9 of 10 100% 8 of 8 ha1g_00847 13 1.01 90% 9 of 10 100% 9 of 9 ha1p_69214 38 0.515 90% 9 of 10 100% 8 of 8 ha1g_00644 3 0.725 89% 8 of 9 100% 9 of 9 ha1p_40164 8 0.655 89% 8 of 9 100% 9 of 9 ha1p_103872 43 0.785 89% 8 of 9 100% 9 of 9 ha1p_110107 17 0.775 88% 7 of 8 100% 7 of 7 ha1p_39189 2 0.59 80% 8 of 10 100% 9 of 9 ha1p_46057 10 0.89 80% 8 of 10 100% 9 of 9 ha1p_45173 19 0.53 80% 8 of 10 100% 9 of 9 ha1p_58853 49 1.215 80% 8 of 10 100% 9 of 9 ha1p_88517 39 0.635 78% 7 of 9 100% 9 of 9 ha1p_80771 20 0.52 70% 7 of 10 100% 9 of 9 ha1p_105937 27 0.64 70% 7 of 10 100% 9 of 9 ha1p_101161 36 0.57 70% 7 of 10 100% 9 of 9 ha1g_02416 15 0.545 60% 6 of 10 100% 8 of 8 ha1p_103824 40 0.515 60% 6 of 10 100% 8 of 8 ha1p_38705 7 0.59 56% 5 of 9 100% 7 of 7 ha1g_02345 24 0.56 56% 5 of 9 100% 8 of 8 ha1p_104423 12 0.515 50% 5 of 10 100% 9 of 9 ha1p_36172 25 0.77 50% 5 of 10 100% 9 of 9 ha1p_70459 26 1.27 50% 5 of 10 100% 9 of 9 ha1p_05406 22 0.73 44% 4 of 9 100% 8 of 8 ha1p_87540 16 0.73 40% 4 of 10 100% 8 of 8 ha1p_89799 18 0.63 38% 3 of 8 100% 9 of 9 ha1p_08347 14 1.745 33% 3 of 9 100% 9 of 9 ha1g_03099 29 0.5 33% 3 of 9 100% 8 of 8 ha1p_89099 28 0.8 30% 3 of 10 100% 9 of 9 ha1p_67625 30 0.91 22% 2 of 9 100% 8 of 8 ha1p_80287 23 0.865 20% 2 of 10 100% 9 of 9 ha1g_00218 31 0.705 10% 1 of 10 100% 8 of 8 ha1p_12535 32 0.585 100% 10 of 10 89% 8 of 9 ha1p_93325 35 0.595 90% 9 of 10 89% 8 of 9 ha1p_29531 48 1.05 80% 8 of 10 89% 8 of 9 ha1p_101251 37 1.635 70% 7 of 10 89% 8 of 9 ha1p_81674 4 0.975 50% 4 of 8 89% 8 of 9 ha1p_67002 51 2.055 50% 5 of 10 89% 8 of 9 ha1g_02210 42 0.845 38% 3 of 8 89% 8 of 9 ha1p_45580 52 1.765 67% 6 of 9 88% 7 of 8 ha1p_12075 46 0.59 78% 7 of 9 83% 5 of 6 ha1p_81149 5 1.11 100% 9 of 9 78% 7 of 9 ha1p_105474 33 0.525 100% 10 of 10 78% 7 of 9 ha1p_22519 47 1.2 100% 10 of 10 78% 7 of 9 ha1p_12646 53 2.385 100% 10 of 10 78% 7 of 9 ha1p_18292 45 1.195 70% 7 of 10 75% 6 of 8 ha1p_56412 44 0.59 90% 9 of 10 67% 6 of 9 ha1g_00681 1 0.58 89% 8 of 9 67% 6 of 9 ha1p_35052 50 1.135 80% 8 of 10 56% 5 of 9 ha1p_69407 21 0.665 90% 9 of 10 44% 4 of 9 Threshold: Average dCt value established by ROC curve analysis as optimal threshold for distinguishing tumor and adjacent normal tissues. Sensitivity: % of positive (i.e. methylation score above Threshold) tumors. Pos. of Total: Number of positive tumors relative to the total number of tumors analyzed. Specificity: % of negative (i.e. methylation score below Threshold) adjacent normal samples. Neg. of Total: Number of negative adjacent normal samples relative to the total number of adjacent normal samples analyzed.
TABLE-US-00016 TABLE 16 Sensitivity and Specificity of differentially methylated loci in colon tumors relative to adjacent histological normal colon tissue. Pos. Neg. Feature Locus Thresh- Sensi- of Speci- of ID Number old tivity Total ficity Total ha1p_56412 44 1.855 88% 7 of 8 100% 8 of 8 ha1g_00644 3 1.46 86% 6 of 7 100% 8 of 8 ha1p_40959 11 2.16 71% 5 of 7 100% 6 of 6 ha1p_23178 9 1.805 63% 5 of 8 100% 8 of 8 ha1p_105937 27 1.425 63% 5 of 8 100% 8 of 8 ha1g_03099 29 0.63 63% 5 of 8 100% 8 of 8 ha1p_74707 34 2.08 63% 5 of 8 100% 8 of 8 ha1p_101161 36 0.65 63% 5 of 8 100% 8 of 8 ha1p_103824 40 0.605 63% 5 of 8 100% 8 of 8 ha1g_02210 42 0.82 63% 5 of 8 100% 8 of 8 ha1p_81674 4 4.63 50% 3 of 6 100% 8 of 8 ha1p_83841 6 2.175 50% 4 of 8 100% 7 of 7 ha1p_80771 20 1.31 50% 4 of 8 100% 8 of 8 ha1p_101251 37 1.29 50% 3 of 6 100% 8 of 8 ha1p_103872 43 2.36 50% 4 of 8 100% 8 of 8 ha1p_67002 51 1.57 50% 4 of 8 100% 8 of 8 ha1p_104423 12 0.575 43% 3 of 7 100% 8 of 8 ha1p_81149 5 2.82 38% 3 of 8 100% 8 of 8 ha1g_02345 24 0.58 38% 3 of 8 100% 8 of 8 ha1g_00218 31 1.745 38% 3 of 8 100% 8 of 8 ha1p_67625 30 0.515 25% 2 of 8 100% 8 of 8 ha1p_105474 33 1.99 100% 8 of 8 88% 7 of 8 ha1p_18292 45 1.545 100% 8 of 8 88% 7 of 8 ha1g_00681 1 0.705 88% 7 of 8 88% 7 of 8 ha1p_108445 41 2.175 88% 7 of 8 88% 7 of 8 ha1p_88517 39 1.645 86% 6 of 7 88% 7 of 8 ha1p_45173 19 1.145 75% 6 of 8 88% 7 of 8 ha1p_89099 28 2.22 75% 6 of 8 88% 7 of 8 ha1p_58853 49 1.85 75% 6 of 8 88% 7 of 8 ha1p_80287 23 1.485 63% 5 of 8 88% 7 of 8 ha1p_29531 48 1.3 63% 5 of 8 88% 7 of 8 ha1p_87540 16 1.52 86% 6 of 7 86% 6 of 7 ha1p_12535 32 0.93 75% 6 of 8 86% 6 of 7 ha1p_38705 7 1.01 50% 3 of 6 86% 6 of 7 ha1p_110107 17 0.74 100% 8 of 8 75% 6 of 8 ha1p_36172 25 0.53 100% 8 of 8 75% 6 of 8 ha1g_00847 13 2.085 88% 7 of 8 75% 6 of 8 ha1p_69214 38 2.085 88% 7 of 8 75% 6 of 8 ha1p_89799 18 1.295 75% 6 of 8 75% 6 of 8 ha1g_02416 15 1.295 63% 5 of 8 75% 6 of 8 ha1p_08347 14 1.415 88% 7 of 8 71% 5 of 7 ha1p_39189 2 0.575 86% 6 of 7 71% 5 of 7 ha1p_46057 10 1.06 100% 8 of 8 63% 5 of 8 ha1p_93325 35 1.07 100% 8 of 8 63% 5 of 8 ha1p_40164 8 0.815 75% 6 of 8 63% 5 of 8 ha1p_70459 26 1.21 75% 6 of 8 63% 5 of 8 ha1p_12075 46 0.935 75% 6 of 8 63% 5 of 8 ha1p_22519 47 1.15 50% 4 of 8 63% 5 of 8 ha1p_05406 22 1.64 75% 6 of 8 57% 4 of 7 ha1p_12646 53 2.16 67% 4 of 6 50% 4 of 8 ha1p_69407 21 0.565 100% 8 of 8 38% 3 of 8 ha1p_35052 50 0.565 100% 8 of 8 38% 3 of 8 ha1p_45580 52 1.505 100% 8 of 8 38% 3 of 8 Threshold: Average dCt value established by ROC curve analysis as optimal threshold for distinguishing tumor and adjacent normal tissues. Sensitivity: % of positive (i.e. methylation score above Threshold) tumors. Pos. of Total: Number of positive tumors relative to the total number of tumors analyzed. Specificity: % of negative (i.e. methylation score below Threshold) adjacent normal samples. Neg. of Total: Number of negative adjacent normal samples relative to the total number of adjacent normal samples analyzed.
TABLE-US-00017 TABLE 17 Sensitivity and Specificity of differentially methylated loci in endometrial tumors relative to adjacent histological normal endometrial tissue. Pos. Neg. Feature Locus Thresh- Sensi- of Speci- of ID Number old tivity Total ficity Total ha1p_39189 2 0.75 93% 13 of 14 100% 9 of 9 ha1g_00644 3 0.91 93% 13 of 14 100% 9 of 9 ha1p_83841 6 1.07 93% 13 of 14 100% 9 of 9 ha1p_103872 43 0.75 93% 13 of 14 100% 9 of 9 ha1p_56412 44 0.685 93% 13 of 14 100% 8 of 8 ha1p_12646 53 2.175 93% 13 of 14 100% 9 of 9 ha1p_40959 11 0.945 86% 12 of 14 100% 3 of 3 ha1p_58853 49 0.51 86% 12 of 14 100% 8 of 8 ha1p_12535 32 1.025 83% 10 of 12 100% 9 of 9 ha1p_18292 45 1.32 83% 10 of 12 100% 8 of 8 ha1p_46057 10 0.935 79% 11 of 14 100% 9 of 9 ha1p_45173 19 0.6 79% 11 of 14 100% 9 of 9 ha1p_105474 33 0.555 79% 11 of 14 100% 9 of 9 ha1p_101251 37 1.28 79% 11 of 14 100% 9 of 9 ha1p_22519 47 2.2 79% 11 of 14 100% 9 of 9 ha1p_29531 48 0.82 79% 11 of 14 100% 9 of 9 ha1p_87540 16 0.56 77% 10 of 13 100% 9 of 9 ha1g_02210 42 0.665 75% 6 of 8 100% 6 of 6 ha1g_00681 1 1.145 71% 10 of 14 100% 9 of 9 ha1p_23178 9 0.795 71% 10 of 14 100% 9 of 9 ha1p_110107 17 0.91 71% 5 of 7 100% 9 of 9 ha1p_105937 27 0.525 71% 10 of 14 100% 9 of 9 ha1p_101161 36 0.55 71% 10 of 14 100% 9 of 9 ha1p_69214 38 0.555 71% 10 of 14 100% 9 of 9 ha1p_88517 39 0.855 69% 9 of 13 100% 8 of 8 ha1p_108445 41 0.805 67% 8 of 12 100% 8 of 8 ha1p_38705 7 1.085 64% 9 of 14 100% 9 of 9 ha1p_40164 8 0.785 64% 9 of 14 100% 9 of 9 ha1p_104423 12 0.705 64% 9 of 14 100% 9 of 9 ha1p_89099 28 0.565 64% 9 of 14 100% 8 of 8 ha1p_05406 22 0.53 50% 7 of 14 100% 9 of 9 ha1p_67002 51 2.02 46% 6 of 13 100% 8 of 8 ha1p_36172 25 0.56 43% 6 of 14 100% 8 of 8 ha1g_03099 29 0.64 43% 6 of 14 100% 9 of 9 ha1p_74707 34 1.885 43% 6 of 14 100% 9 of 9 ha1p_35052 50 1.63 43% 6 of 14 100% 9 of 9 ha1p_45580 52 1.435 43% 6 of 14 100% 8 of 8 ha1g_02345 24 0.6 36% 5 of 14 100% 8 of 8 ha1p_67625 30 0.56 31% 4 of 13 100% 8 of 8 ha1p_80287 23 0.51 21% 3 of 14 100% 9 of 9 ha1g_00218 31 0.535 21% 3 of 14 100% 9 of 9 ha1p_103824 40 0.645 21% 3 of 14 100% 9 of 9 ha1p_81149 5 1.165 86% 12 of 14 89% 8 of 9 ha1p_81674 4 0.875 82% 9 of 11 89% 8 of 9 ha1g_00847 13 1.11 79% 11 of 14 89% 8 of 9 ha1p_69407 21 1.59 79% 11 of 14 89% 8 of 9 ha1p_93325 35 0.795 77% 10 of 13 89% 8 of 9 ha1p_70459 26 0.655 71% 10 of 14 89% 8 of 9 ha1p_80771 20 0.58 64% 9 of 14 89% 8 of 9 ha1p_08347 14 1.86 57% 8 of 14 89% 8 of 9 ha1g_02416 15 0.61 50% 7 of 14 89% 8 of 9 ha1p_89799 18 0.52 62% 8 of 13 88% 7 of 8 ha1p_12075 46 0.915 85% 11 of 13 78% 7 of 9 Threshold: Average dCt value established by ROC curve analysis as optimal threshold for distinguishing tumor and adjacent normal tissues. Sensitivity: % of positive (i.e. methylation score above Threshold) tumors. Pos. of Total: Number of positive tumors relative to the total number of tumors analyzed. Specificity: % of negative (i.e. methylation score below Threshold) adjacent normal samples. Neg. of Total: Number of negative adjacent normal samples relative to the total number of adjacent normal samples analyzed.
TABLE-US-00018 TABLE 18 Sensitivity and Specificity of differentially methylated loci in esophageal tumors relative to adjacent histological normal esophageal tissue. Pos. Neg. Feature Locus Thresh- Sensi- of Speci- of ID Number old tivity Total ficity Total ha1p_110107 17 0.515 67% 6 of 9 100% 9 of 9 ha1p_38705 7 2.58 43% 3 of 7 100% 9 of 9 ha1p_87540 16 1.21 33% 3 of 9 100% 9 of 9 ha1p_67625 30 0.665 33% 3 of 9 100% 9 of 9 ha1p_103824 40 0.72 13% 1 of 8 100% 10 of 10 ha1p_05406 22 0.71 11% 1 of 9 100% 10 of 10 ha1g_03099 29 0.6 11% 1 of 9 100% 10 of 10 ha1p_39189 2 1.165 89% 8 of 9 90% 9 of 10 ha1p_29531 48 1.27 78% 7 of 9 90% 9 of 10 ha1g_02416 15 0.65 38% 3 of 8 90% 9 of 10 ha1p_80771 20 0.675 22% 2 of 9 90% 9 of 10 ha1p_45173 19 0.985 100% 9 of 9 89% 8 of 9 ha1p_88517 39 1.14 100% 8 of 8 89% 8 of 9 ha1p_89799 18 0.53 14% 1 of 7 89% 8 of 9 ha1p_40959 11 1.52 78% 7 of 9 88% 7 of 8 ha1g_02210 42 0.905 33% 3 of 9 88% 7 of 8 ha1p_23178 9 1.645 100% 9 of 9 80% 8 of 10 ha1p_46057 10 0.92 100% 9 of 9 80% 8 of 10 ha1p_104423 12 0.65 100% 9 of 9 80% 8 of 10 ha1p_08347 14 0.75 100% 9 of 9 80% 8 of 10 ha1p_108445 41 1.715 100% 9 of 9 80% 8 of 10 ha1p_105937 27 0.855 89% 8 of 9 80% 8 of 10 ha1p_105474 33 1.655 89% 8 of 9 80% 8 of 10 ha1p_101161 36 0.785 89% 8 of 9 80% 8 of 10 ha1p_22519 47 1.77 89% 8 of 9 80% 8 of 10 ha1p_81149 5 2.02 78% 7 of 9 80% 8 of 10 ha1g_00644 3 0.905 75% 6 of 8 80% 8 of 10 ha1p_56412 44 0.74 67% 6 of 9 80% 8 of 10 ha1p_74707 34 1.035 56% 5 of 9 80% 8 of 10 ha1p_80287 23 0.62 22% 2 of 9 80% 8 of 10 ha1p_36172 25 0.6 22% 2 of 9 80% 8 of 10 ha1p_67002 51 1.925 78% 7 of 9 78% 7 of 9 ha1p_89099 28 0.6 56% 5 of 9 78% 7 of 9 ha1p_18292 45 1.18 89% 8 of 9 75% 6 of 8 ha1p_58853 49 1.105 100% 9 of 9 70% 7 of 10 ha1p_83841 6 1.125 89% 8 of 9 70% 7 of 10 ha1p_12535 32 0.78 89% 8 of 9 70% 7 of 10 ha1p_101251 37 1.025 78% 7 of 9 70% 7 of 10 ha1g_00847 13 0.825 100% 9 of 9 67% 6 of 9 ha1p_69407 21 1.005 100% 9 of 9 60% 6 of 10 ha1p_93325 35 0.93 89% 8 of 9 60% 6 of 10 ha1g_00681 1 0.52 67% 6 of 9 60% 6 of 10 ha1p_70459 26 0.515 100% 9 of 9 56% 5 of 9 ha1p_40164 8 0.645 56% 5 of 9 56% 5 of 9 ha1p_69214 38 0.73 100% 9 of 9 50% 5 of 10 ha1p_103872 43 1.5 100% 9 of 9 50% 5 of 10 ha1p_81674 4 0.645 75% 6 of 8 44% 4 of 9 ha1p_12075 46 1.02 100% 7 of 7 40% 4 of 10 ha1p_45580 52 0.73 100% 9 of 9 40% 4 of 10 ha1p_35052 50 1.84 100% 9 of 9 30% 3 of 10 ha1p_12646 53 1.085 100% 9 of 9 30% 3 of 10 ha1g_02345 24 0.83 89% 8 of 9 10% 1 of 10 ha1g_00218 31 -- -- -- -- -- Threshold: Average dCt value established by ROC curve analysis as optimal threshold for distinguishing tumor and adjacent normal tissues. Sensitivity: % of positive (i.e. methylation score above Threshold) tumors. Pos. of Total: Number of positive tumors relative to the total number of tumors analyzed. Specificity: % of negative (i.e. methylation score below Threshold) adjacent normal samples. Neg. of Total: Number of negative adjacent normal samples relative to the total number of adjacent normal samples analyzed.
TABLE-US-00019 TABLE 19 Sensitivity and Specificity of differentially methylated loci in prostate tumors relative to adjacent histological normal prostate tissue. Pos. Neg. Feature Locus Thresh- Sensi- of Speci- of ID Number old tivity Total ficity Total ha1p_38705 7 0.595 78% 7 of 9 100% 9 of 9 ha1p_36172 25 1 67% 6 of 9 100% 9 of 9 ha1p_56412 44 1.63 67% 6 of 9 100% 9 of 9 ha1p_45580 52 1.785 67% 6 of 9 100% 9 of 9 ha1p_12646 53 3.13 67% 6 of 9 100% 9 of 9 ha1p_67002 51 2.05 56% 5 of 9 100% 9 of 9 ha1g_02416 15 0.845 44% 4 of 9 100% 9 of 9 ha1p_103824 40 0.59 22% 2 of 9 100% 9 of 9 ha1p_104423 12 0.655 11% 1 of 9 100% 9 of 9 ha1p_45173 19 0.53 11% 1 of 9 100% 9 of 9 ha1g_03099 29 2.165 11% 1 of 9 100% 8 of 8 ha1p_89799 18 0.51 75% 6 of 8 89% 8 of 9 ha1g_02210 42 0.715 75% 6 of 8 89% 8 of 9 ha1p_46057 10 0.605 67% 6 of 9 89% 8 of 9 ha1p_108445 41 0.83 67% 6 of 9 89% 8 of 9 ha1p_80287 23 0.545 63% 5 of 8 89% 8 of 9 ha1p_87540 16 0.54 56% 5 of 9 89% 8 of 9 ha1p_74707 34 1.425 56% 5 of 9 89% 8 of 9 ha1p_18292 45 1.5 56% 5 of 9 89% 8 of 9 ha1p_35052 50 0.73 56% 5 of 9 89% 8 of 9 ha1g_02345 24 0.635 44% 4 of 9 89% 8 of 9 ha1p_88517 39 0.885 44% 4 of 9 89% 8 of 9 ha1p_12075 46 1.15 44% 4 of 9 89% 8 of 9 ha1p_69407 21 0.75 38% 3 of 8 89% 8 of 9 ha1p_80771 20 0.585 33% 3 of 9 89% 8 of 9 ha1p_05406 22 0.745 33% 3 of 9 89% 8 of 9 ha1p_70459 26 0.615 33% 3 of 9 89% 8 of 9 ha1g_00218 31 0.675 11% 1 of 9 89% 8 of 9 ha1p_69214 38 1.175 88% 7 of 8 88% 7 of 8 ha1p_67625 30 0.53 33% 3 of 9 88% 7 of 8 ha1p_110107 17 1.15 0% 0 of 8 88% 7 of 8 ha1p_105937 27 0.545 100% 9 of 9 78% 7 of 9 ha1p_103872 43 1.64 100% 9 of 9 78% 7 of 9 ha1p_22519 47 1.38 100% 9 of 9 78% 7 of 9 ha1p_29531 48 0.77 100% 9 of 9 78% 7 of 9 ha1p_83841 6 0.515 89% 8 of 9 78% 7 of 9 ha1p_105474 33 1.35 89% 8 of 9 78% 7 of 9 ha1p_101161 36 0.875 89% 8 of 9 78% 7 of 9 ha1g_00644 3 0.56 88% 7 of 8 78% 7 of 9 ha1p_39189 2 0.53 78% 7 of 9 78% 7 of 9 ha1p_81149 5 1.17 78% 7 of 9 78% 7 of 9 ha1p_08347 14 1.405 67% 6 of 9 78% 7 of 9 ha1p_12535 32 1.19 67% 6 of 9 78% 7 of 9 ha1p_40164 8 0.7 63% 5 of 8 78% 7 of 9 ha1p_23178 9 1.575 56% 5 of 9 78% 7 of 9 ha1p_89099 28 0.5 56% 5 of 9 78% 7 of 9 ha1p_40959 11 0.745 100% 8 of 8 67% 6 of 9 ha1p_93325 35 0.535 100% 9 of 9 67% 6 of 9 ha1p_101251 37 1.27 100% 8 of 8 67% 6 of 9 ha1p_81674 4 1.245 78% 7 of 9 67% 6 of 9 ha1g_00847 13 0.63 78% 7 of 9 67% 6 of 9 ha1g_00681 1 0.55 50% 4 of 8 67% 6 of 9 ha1p_58853 49 0.835 100% 9 of 9 22% 2 of 9 Threshold: Average dCt value established by ROC curve analysis as optimal threshold for distinguishing tumor and adjacent normal tissues. Sensitivity: % of positive (i.e. methylation score above Threshold) tumors. Pos. of Total: Number of positive tumors relative to the total number of tumors analyzed. Specificity: % of negative (i.e. methylation score below Threshold) adjacent normal samples. Neg. of Total: Number of negative adjacent normal samples relative to the total number of adjacent normal samples analyzed.
TABLE-US-00020 TABLE 20 Frequency of methylation of each locus in melanoma tumors. Feature ID Locus Number Sensitivity Pos. of Total ha1p_81149 5 100% 7 of 7 ha1p_38705 7 100% 5 of 5 ha1p_23178 9 100% 7 of 7 hal p_45173 19 100% 6 of 6 ha1p_12535 32 100% 7 of 7 ha1p_69214 38 100% 7 of 7 ha1p_108445 41 100% 7 of 7 ha1p_45580 52 100% 7 of 7 ha1p_12646 53 100% 7 of 7 ha1g_00644 3 86% 6 of 7 ha1p_46057 10 86% 6 of 7 ha1p_40959 11 86% 6 of 7 ha1p_104423 12 86% 6 of 7 ha1p_105474 33 86% 6 of 7 ha1p_93325 35 86% 6 of 7 ha1p_103872 43 86% 6 of 7 ha1p_56412 44 86% 6 of 7 ha1p_18292 45 86% 6 of 7 ha1p_22519 47 86% 6 of 7 ha1p_29531 48 86% 6 of 7 ha1p_58853 49 86% 6 of 7 ha1p_35052 50 86% 6 of 7 ha1p_67002 51 86% 6 of 7 ha1p_81674 4 83% 5 of 6 ha1p_69407 21 83% 5 of 6 ha1p_12075 46 80% 4 of 5 ha1g_00681 1 71% 5 of 7 ha1p_39189 2 71% 5 of 7 ha1p_83841 6 71% 5 of 7 ha1p_40164 8 71% 5 of 7 ha1g_00847 13 71% 5 of 7 ha1p_87540 16 57% 4 of 7 ha1p_101251 37 57% 4 of 7 ha1p_88517 39 57% 4 of 7 ha1p_08347 14 50% 3 of 6 ha1p_05406 22 43% 3 of 7 ha1p_105937 27 43% 3 of 7 ha1p_89099 28 43% 3 of 7 ha1g_02210 42 43% 3 of 7 ha1p_89799 18 40% 2 of 5 ha1p_80287 23 29% 2 of 7 ha1p_36172 25 29% 2 of 7 ha1p_70459 26 29% 2 of 7 ha1g_03099 29 29% 2 of 7 ha1p_101161 36 29% 2 of 7 ha1p_110107 17 14% 1 017 ha1p_80771 20 14% 1 of 7 ha1p_67625 30 14% 1 of 7 ha1p_74707 34 14% 1 of 7 ha1g_02416 15 0% 0 of 7 ha1g_02345 24 0% 0 of 7 ha1g_00218 31 0% 0 of 7 ha1p_103824 40 0% 0 of 7 Sensitivity: % of positive (i.e. methylation score above 1.0) tumors. Pos. of Total: Number of positive tumors relative to the total number of tumors analyzed. Note that adjacent histology normal or normal skin samples were not available for analysis. Threshold for a positive methylation score was set at an average dCt of 1.0.
[0187] Although the invention has been described in some detail by way of illustration and example for purposes of clarity of understanding, it will be readily apparent to one of ordinary skill in the art in light of the teachings of this invention that certain changes and modifications may be made thereto without departing from the spirit or scope of the appended claims.
[0188] All publications, databases, Genbank sequences, patents, and patent applications cited in this specification are herein incorporated by reference as if each was specifically and individually indicated to be incorporated by reference.
Sequence CWU
1
SEQUENCE LISTING
<160> NUMBER OF SEQ ID NOS: 265
<210> SEQ ID NO 1
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_00681
<400> SEQUENCE: 1
tcgtagtagg tcgctttttg catcgcgttg tttcacgatc ttgatcgcac actctgacag 60
<210> SEQ ID NO 2
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_39189
<400> SEQUENCE: 2
accctacagc agactctcta ccactaccga gtgatacaaa ggactgggat tctggacagg 60
<210> SEQ ID NO 3
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_00644
<400> SEQUENCE: 3
cagttcctcc accgcagcgg tcacaccgtt gatttgatcc agaaataaga cggatagtac 60
<210> SEQ ID NO 4
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_81674
<400> SEQUENCE: 4
ctttcggtct cctccccatt ttcctagtcg tcttcggttg tggatgttgt aaactcgacc 60
<210> SEQ ID NO 5
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_81149
<400> SEQUENCE: 5
cccaggaggc tatgggaatc agaatcacac ttgcacaaga gaagaccctt atgggacaag 60
<210> SEQ ID NO 6
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_83841
<400> SEQUENCE: 6
aaataccacc ttcttaaata ccacccagct gtccaagatg gagacttcct ggcatccagg 60
<210> SEQ ID NO 7
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_38705
<400> SEQUENCE: 7
ggaggagtaa aggctgttta caaacttgac gtacacacgc agtcctatcc ctacggtcct 60
<210> SEQ ID NO 8
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_40164
<400> SEQUENCE: 8
aaacaagcac cctgactggc gcattcttac tcattctagc ctgggtttca acttcaagga 60
<210> SEQ ID NO 9
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_23178
<400> SEQUENCE: 9
cccttactgc tgctgctgta acagctaagt gccaattatc tcccaagcgt gaaagcaaat 60
<210> SEQ ID NO 10
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_46057
<400> SEQUENCE: 10
gaaacatgca ctgcctgaca tcggcaagct gcccacacca agttacaggc ttatggaaag 60
<210> SEQ ID NO 11
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_40959
<400> SEQUENCE: 11
cgtgggcctt agccaaataa cttctggtag gcaaattctc cccttcttca gttgagagct 60
<210> SEQ ID NO 12
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_104423
<400> SEQUENCE: 12
gagagggaag cctgatctgt ttcctcactc gcttgctcgt ggatgtcatt ttctgtcttc 60
<210> SEQ ID NO 13
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_00847
<400> SEQUENCE: 13
atacgctgga acagagcacg agcatacact cgaacacacg cgcacacact caggacatct 60
<210> SEQ ID NO 14
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_08347
<400> SEQUENCE: 14
atggtttctg aaaagccctc agtcctggtt cttggcttcc tgattctgtg gttgggattt 60
<210> SEQ ID NO 15
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_02416
<400> SEQUENCE: 15
caacgacaag aagctgtcca aatatgagac cctgcagatg gcccaaatct acatcaacgc 60
<210> SEQ ID NO 16
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_87540
<400> SEQUENCE: 16
gaggcaattc agggagacag gaacaccctt ctctcttcac acacctcatc agttccactg 60
<210> SEQ ID NO 17
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_110107
<400> SEQUENCE: 17
tgtgtgtgtc catttggcga gatgtcgaga gcggggggag tgtccttgtc ggtgtatctg 60
<210> SEQ ID NO 18
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_89799
<400> SEQUENCE: 18
tctcccagca ccttgttaat ttctctcaat ctccagccac aaatccgaga cacaacgctc 60
<210> SEQ ID NO 19
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_45173
<400> SEQUENCE: 19
agcgtgccta gaggagtggt caggatagtg agggatctgt gatccttcgt tctgaatcta 60
<210> SEQ ID NO 20
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_80771
<400> SEQUENCE: 20
ccggagagcc tgtcaaggga agagctgaat cttttatctt ttgtaacgac tacccagtga 60
<210> SEQ ID NO 21
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_69407
<400> SEQUENCE: 21
ggcctgtctc cttggcatgt tcccttgctt ctgcttgtcc agttaatcct ttctgacata 60
<210> SEQ ID NO 22
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_05406
<400> SEQUENCE: 22
gaaggaatgg cccatctctt agggctctct gcttgtcacc taccaggttg gtcagaaacg 60
<210> SEQ ID NO 23
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_80287
<400> SEQUENCE: 23
gctccagaca cagagaaagg tttcttaaca ctcaggttcg cttctcctaa ggtgtgtgcc 60
<210> SEQ ID NO 24
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_02345
<400> SEQUENCE: 24
ttttgacctg tgatttgttg tccggcagct ttcagtgtcg gttttacgag gtagagtgat 60
<210> SEQ ID NO 25
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_36172
<400> SEQUENCE: 25
tttcctagtc gatcccagct tctctaggga gtgtcaggcg cacacagggt taagttagtt 60
<210> SEQ ID NO 26
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_70459
<400> SEQUENCE: 26
tttccatgac agaggtttca ggatctctta gaaggaagaa agtagagacg gtgaagagct 60
<210> SEQ ID NO 27
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_105937
<400> SEQUENCE: 27
atcctcagga gtaataaccc ctccgattgt tgctcaggtc cctccctctt gaaattcctg 60
<210> SEQ ID NO 28
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_89099
<400> SEQUENCE: 28
ggctcggaaa gccttcatag taagggcgca gttaagactt ggatttcctg ccattacaca 60
<210> SEQ ID NO 29
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_03099
<400> SEQUENCE: 29
catgcagaaa gctgggcagc atagaaagtt cacagccacg gaaagatcaa agagatggtg 60
<210> SEQ ID NO 30
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_67625
<400> SEQUENCE: 30
tttgccatct ctacagattt caccatctct cttcccctct ccccctcgtt cgctttcctc 60
<210> SEQ ID NO 31
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_00218
<400> SEQUENCE: 31
ttccatcttt tgtggcgcga aaataaccct ttgctccctc gttggttttg ttgaggttga 60
<210> SEQ ID NO 32
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_12535
<400> SEQUENCE: 32
tgctatcttg tacctaaact gagccctttt ggtggaggca gtgagggttc ttgtgtgttc 60
<210> SEQ ID NO 33
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_105474
<400> SEQUENCE: 33
ttctccttcg agcatattcg ggaagggaag tttgaagagt gagtccctgt gagggccgtg 60
<210> SEQ ID NO 34
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_74707
<400> SEQUENCE: 34
ggccttgagg gcaagacgag gaatttcgac ttaggtcctt gaatctggag agctacagaa 60
<210> SEQ ID NO 35
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_93325
<400> SEQUENCE: 35
tggagcacac aggcagcatt acgccattct tccttcttgg aaaaatccct cagccttata 60
<210> SEQ ID NO 36
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_101161
<400> SEQUENCE: 36
agagagataa agagagatga cctcagagac aaagagactc agacccagcc agaggcccaa 60
<210> SEQ ID NO 37
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_101251
<400> SEQUENCE: 37
tattctttgt tgcccatttg tctagggact gtctgcgtgg ctgtgactat gagtgtcagc 60
<210> SEQ ID NO 38
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_69214
<400> SEQUENCE: 38
acaacctggg aactgaataa ctttcaaagc cagtgctcag cttctctgct ccgtactagc 60
<210> SEQ ID NO 39
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_88517
<400> SEQUENCE: 39
ctgtgtcagg tatttaacag ttctggggac acgggtgtta cctcctttca tggtgctctc 60
<210> SEQ ID NO 40
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_103824
<400> SEQUENCE: 40
agactcgctg ttcccgactg tcgctcccta gctctgatga aaccccgaca tttctttcag 60
<210> SEQ ID NO 41
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_108445
<400> SEQUENCE: 41
gtgttcttgg cacatggtag gcatctgtct ttgttgggca gttgcatcag aagggttaag 60
<210> SEQ ID NO 42
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_02210
<400> SEQUENCE: 42
ctgcactctc ggcttctttc tgtggcttcc ctctttttct cttcacctct gttttcagga 60
<210> SEQ ID NO 43
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_103872
<400> SEQUENCE: 43
gctaaaatcc tcctggcccc atcatttctt gggtcctttc cagacagtgc tgtgtcttta 60
<210> SEQ ID NO 44
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_56412
<400> SEQUENCE: 44
gggatgtgtg cctccaactt cattaagtga gggaaacatt tgctggggct tgtcagggag 60
<210> SEQ ID NO 45
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_18292
<400> SEQUENCE: 45
tttggtttgt cacctgtgag ttgcctactg gacacaaaga tgaagctgtc gggaaagtga 60
<210> SEQ ID NO 46
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_12075
<400> SEQUENCE: 46
gttgatcttc aacatggcta accaaatgga cgatcagcag gcagacacga ggtattttca 60
<210> SEQ ID NO 47
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_22519
<400> SEQUENCE: 47
tgtttggatg atgggacaca tcaccctggg aactgtctca aagcacaacc acatcttagg 60
<210> SEQ ID NO 48
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_29531
<400> SEQUENCE: 48
cctccttctc cctcagagta cagttcaact cttttaagag gaaagccact gaatgaacct 60
<210> SEQ ID NO 49
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_58853
<400> SEQUENCE: 49
ggggagggtc tctgcacctt tcctgacatc ttttcttcgg gagatcctca tagaaccata 60
<210> SEQ ID NO 50
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_35052
<400> SEQUENCE: 50
gagacaacgc cctcagaaat gagagaacag taccctctta tccttgctgc actttccagc 60
<210> SEQ ID NO 51
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_67002
<400> SEQUENCE: 51
atgctctttg tgcccagact gccctctata aatcagcact atcaaccctg tccagagact 60
<210> SEQ ID NO 52
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_45580
<400> SEQUENCE: 52
gccatctgca tagcctaact ctgccaccct ggcttggaca attatggtga tttctctgat 60
<210> SEQ ID NO 53
<211> LENGTH: 60
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_12646
<400> SEQUENCE: 53
agggcctcta gtttgagttt tgccatctat taggatagaa agcacacagt ttgcctgatt 60
<210> SEQ ID NO 54
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_00681 left PCR primer
<400> SEQUENCE: 54
agatcgccga gctgtcgtag tag 23
<210> SEQ ID NO 55
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_39189 left PCR primer
<400> SEQUENCE: 55
cgttctcgat ccagttccat ctc 23
<210> SEQ ID NO 56
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_00644 left PCR primer
<400> SEQUENCE: 56
tatcatcatt agacccggga tgg 23
<210> SEQ ID NO 57
<211> LENGTH: 24
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarrayfeature identifier
ha1p_81674 left PCR primer
<400> SEQUENCE: 57
ttcggtctcc tccccatttt ccta 24
<210> SEQ ID NO 58
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_81149 left PCR primer
<400> SEQUENCE: 58
gcaaataggt caatgctggg aac 23
<210> SEQ ID NO 59
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_83841 left PCR primer
<400> SEQUENCE: 59
aagttcccaa gcacgaagtg ttc 23
<210> SEQ ID NO 60
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_38705 left PCR primer
<400> SEQUENCE: 60
tccaggtagt cgtttctgaa gcc 23
<210> SEQ ID NO 61
<211> LENGTH: 19
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_40164 left PCR primer
<400> SEQUENCE: 61
gcccgccctg caaccaacc 19
<210> SEQ ID NO 62
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_23178 left PCR primer
<400> SEQUENCE: 62
ttctcagagt gttggtaccg cag 23
<210> SEQ ID NO 63
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_46057 left PCR primer
<400> SEQUENCE: 63
ggttgccagg acacaaagta agc 23
<210> SEQ ID NO 64
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_40959 left PCR primer
<400> SEQUENCE: 64
tcagttgaga gctcagagca agc 23
<210> SEQ ID NO 65
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_104423 left PCR primer
<400> SEQUENCE: 65
tgatctgttt cctcactcgc ttg 23
<210> SEQ ID NO 66
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_00847 left PCR primer
<400> SEQUENCE: 66
atgggtggat ggatggatag atg 23
<210> SEQ ID NO 67
<211> LENGTH: 24
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_08347 left PCR primer
<400> SEQUENCE: 67
ggaggactgc cccatatttt cact 24
<210> SEQ ID NO 68
<211> LENGTH: 21
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_02416 left PCR primer
<400> SEQUENCE: 68
gcgccccggg acgaggtgga c 21
<210> SEQ ID NO 69
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_87540 left PCR primer
<400> SEQUENCE: 69
gttaatggag ggtgagggtt tcc 23
<210> SEQ ID NO 70
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_110107 left PCR primer
<400> SEQUENCE: 70
gctgggtgaa tagtcacgga atc 23
<210> SEQ ID NO 71
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_89799 left PCR primer
<400> SEQUENCE: 71
aacgctcttc ctccaaagag gtc 23
<210> SEQ ID NO 72
<211> LENGTH: 27
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_45173 left PCR primer
<400> SEQUENCE: 72
gttcttctaa gcttcattcc acaagag 27
<210> SEQ ID NO 73
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_80771 left PCR primer
<400> SEQUENCE: 73
ggtgaaatat gtgcggactg atg 23
<210> SEQ ID NO 74
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_69407 left PCR primer
<400> SEQUENCE: 74
ctcattcatg cataggtcac act 23
<210> SEQ ID NO 75
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_05406 left PCR primer
<400> SEQUENCE: 75
ctccttccca ctaggctgca gag 23
<210> SEQ ID NO 76
<211> LENGTH: 22
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_80287 left PCR primer
<400> SEQUENCE: 76
aggcctggga ggtgactcat ag 22
<210> SEQ ID NO 77
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_02345 left PCR primer
<400> SEQUENCE: 77
gtagatgcgg aaattggcct cag 23
<210> SEQ ID NO 78
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_36172 left PCR primer
<400> SEQUENCE: 78
cctagacagc aacacaccca ctg 23
<210> SEQ ID NO 79
<211> LENGTH: 24
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_70459 left PCR primer
<400> SEQUENCE: 79
ttcaccgtct ctactttctt cctt 24
<210> SEQ ID NO 80
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_105937 left PCR primer
<400> SEQUENCE: 80
ctctaaacac tcgcctctac ccg 23
<210> SEQ ID NO 81
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_89099 left PCR primer
<400> SEQUENCE: 81
tagcccttga cagcagttgt gac 23
<210> SEQ ID NO 82
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_03099 left PCR primer
<400> SEQUENCE: 82
agagccacgt gagctgcatt aac 23
<210> SEQ ID NO 83
<211> LENGTH: 22
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_67625 left PCR primer
<400> SEQUENCE: 83
cctggagtcc tagagagcct cg 22
<210> SEQ ID NO 84
<211> LENGTH: 21
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_00218 left PCR primer
<400> SEQUENCE: 84
gccgcgccac cccacctgag t 21
<210> SEQ ID NO 85
<211> LENGTH: 21
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_12535 left PCR primer
<400> SEQUENCE: 85
agtgttgggt gctgggagga g 21
<210> SEQ ID NO 86
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_105474 left PCR primer
<400> SEQUENCE: 86
ctctgggctt tctctagctt ccc 23
<210> SEQ ID NO 87
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_74707 left PCR primer
<400> SEQUENCE: 87
agtttgtgag ctcaggagaa gcg 23
<210> SEQ ID NO 88
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_93325 left PCR primer
<400> SEQUENCE: 88
ccagtcccat agtggaaatg ctc 23
<210> SEQ ID NO 89
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_101161 left PCR primer
<400> SEQUENCE: 89
actaccttgg gtgtcagtcc tgc 23
<210> SEQ ID NO 90
<211> LENGTH: 24
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_101251 left PCR primer
<400> SEQUENCE: 90
tggacacatg tgctacacgc taag 24
<210> SEQ ID NO 91
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_69214 left PCR primer
<400> SEQUENCE: 91
aggtcactgc agaaggatgg aac 23
<210> SEQ ID NO 92
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_88517 left PCR primer
<400> SEQUENCE: 92
gggactcatt caatgtcaag tgc 23
<210> SEQ ID NO 93
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_103824 left PCR primer
<400> SEQUENCE: 93
tctttagacg ctgcgctctt agc 23
<210> SEQ ID NO 94
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_108445 left PCR primer
<400> SEQUENCE: 94
catctgtctt tgttgggcag ttg 23
<210> SEQ ID NO 95
<211> LENGTH: 21
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_02210 left PCR primer
<400> SEQUENCE: 95
cccaagtact cggcactgca c 21
<210> SEQ ID NO 96
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_103872 left PCR primer
<400> SEQUENCE: 96
tgagattcaa tttctcgccc ttc 23
<210> SEQ ID NO 97
<211> LENGTH: 18
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_56412 left PCR primer
<400> SEQUENCE: 97
tgccggtctg ctctgctc 18
<210> SEQ ID NO 98
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_18292 left PCR primer
<400> SEQUENCE: 98
ttctcctggg tctttccaaa cag 23
<210> SEQ ID NO 99
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_12075 left PCR primer
<400> SEQUENCE: 99
gtttgccaaa tgacagctgt ttg 23
<210> SEQ ID NO 100
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_22519 left PCR primer
<400> SEQUENCE: 100
ctcacgttaa tcaacccgag tcc 23
<210> SEQ ID NO 101
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_29531 left PCR primer
<400> SEQUENCE: 101
ctccagcact ttgggaatga aag 23
<210> SEQ ID NO 102
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_58853 left PCR primer
<400> SEQUENCE: 102
atgtcaggaa aggtgcagag acc 23
<210> SEQ ID NO 103
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_35052 left PCR primer
<400> SEQUENCE: 103
atcttcccag tagggctgaa tcc 23
<210> SEQ ID NO 104
<211> LENGTH: 24
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_67002 left PCR primer
<400> SEQUENCE: 104
cagtgctccg tgtccccaag tagt 24
<210> SEQ ID NO 105
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_45580 left PCR primer
<400> SEQUENCE: 105
gggtgcagga tgaagactag ctg 23
<210> SEQ ID NO 106
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_12646 left PCR primer
<400> SEQUENCE: 106
gccttaggaa tttccatccc aac 23
<210> SEQ ID NO 107
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_00681 right PCR primer
<400> SEQUENCE: 107
aggccaagga gcagaaacta agc 23
<210> SEQ ID NO 108
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_39189 right PCR primer
<400> SEQUENCE: 108
accgagtgat acaaaggact ggg 23
<210> SEQ ID NO 109
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarrayfeature identifier
ha1g_00644 right PCR primer
<400> SEQUENCE: 109
gggttaatgg agcactacat gcc 23
<210> SEQ ID NO 110
<211> LENGTH: 24
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_81674 right PCR primer
<400> SEQUENCE: 110
acggccccag agcagcagca agac 24
<210> SEQ ID NO 111
<211> LENGTH: 19
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_81149 right PCR primer
<400> SEQUENCE: 111
atgcctgccc tgaccacac 19
<210> SEQ ID NO 112
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_83841 right PCR primer
<400> SEQUENCE: 112
ttagaaccag gtctctgcct tgc 23
<210> SEQ ID NO 113
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_38705 right PCR primer
<400> SEQUENCE: 113
ccttccttct ctgcctttca atg 23
<210> SEQ ID NO 114
<211> LENGTH: 19
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_40164 right PCR primer
<400> SEQUENCE: 114
tgccctcccc agcgtcttt 19
<210> SEQ ID NO 115
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_23178 right PCR primer
<400> SEQUENCE: 115
gaataaagac atgccaaggc cag 23
<210> SEQ ID NO 116
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_46057 right PCR primer
<400> SEQUENCE: 116
catggaagca taagaccatg ctg 23
<210> SEQ ID NO 117
<211> LENGTH: 18
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_40959 right PCR primer
<400> SEQUENCE: 117
acttccggag acagccgc 18
<210> SEQ ID NO 118
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_104423 right PCR primer
<400> SEQUENCE: 118
gcgattgttc tacgaaagtg tgg 23
<210> SEQ ID NO 119
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_00847 right PCR primer
<400> SEQUENCE: 119
gggcggtgat catttagttt ctg 23
<210> SEQ ID NO 120
<211> LENGTH: 24
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_08347 right PCR primer
<400> SEQUENCE: 120
ctggctgtcc cctatcgtaa cctc 24
<210> SEQ ID NO 121
<211> LENGTH: 22
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_02416 right PCR primer
<400> SEQUENCE: 121
gctggaggcg gcggtggctg tt 22
<210> SEQ ID NO 122
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_87540 right PCR primer
<400> SEQUENCE: 122
gttcattccc tccaacattc ctc 23
<210> SEQ ID NO 123
<211> LENGTH: 22
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_110107 right PCR primer
<400> SEQUENCE: 123
caaggcatag tactcctccg gg 22
<210> SEQ ID NO 124
<211> LENGTH: 21
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_89799 right PCR primer
<400> SEQUENCE: 124
gctgtgagag gagcggaaga g 21
<210> SEQ ID NO 125
<211> LENGTH: 21
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_45173 right PCR primer
<400> SEQUENCE: 125
gggttaaggc tggactctgg c 21
<210> SEQ ID NO 126
<211> LENGTH: 19
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_80771 right PCR primer
<400> SEQUENCE: 126
ccctttcatt cacctggcg 19
<210> SEQ ID NO 127
<211> LENGTH: 21
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_69407 right PCR primer
<400> SEQUENCE: 127
tggggaggag caatagagat a 21
<210> SEQ ID NO 128
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_05406 right PCR primer
<400> SEQUENCE: 128
aaacaaccac tgctcctgtc tcc 23
<210> SEQ ID NO 129
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_80287 right PCR primer
<400> SEQUENCE: 129
taaggtgtgt gcctaaccca tcc 23
<210> SEQ ID NO 130
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_02345 right PCR primer
<400> SEQUENCE: 130
atatttgagc ctcttgccct tcc 23
<210> SEQ ID NO 131
<211> LENGTH: 22
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_36172 right PCR primer
<400> SEQUENCE: 131
gtcttctcct tgcaatgggc tc 22
<210> SEQ ID NO 132
<211> LENGTH: 24
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_70459 right PCR primer
<400> SEQUENCE: 132
gttgctgttc ttatccccat tcta 24
<210> SEQ ID NO 133
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_105937 right PCR primer
<400> SEQUENCE: 133
cccatcctgt agacagatca ggg 23
<210> SEQ ID NO 134
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_89099 right PCR primer
<400> SEQUENCE: 134
gactaatgcc catgacccag aag 23
<210> SEQ ID NO 135
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_03099 right PCR primer
<400> SEQUENCE: 135
catgcttaga ggtgaacgtg tgg 23
<210> SEQ ID NO 136
<211> LENGTH: 19
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_67625 right PCR primer
<400> SEQUENCE: 136
gtgcagggtg ggtgagagg 19
<210> SEQ ID NO 137
<211> LENGTH: 22
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_00218 right PCR primer
<400> SEQUENCE: 137
gcggctccgg ggccaatgaa tg 22
<210> SEQ ID NO 138
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_12535 right PCR primer
<400> SEQUENCE: 138
tgagggttct tgtgtgttct tcg 23
<210> SEQ ID NO 139
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_105474 right PCR primer
<400> SEQUENCE: 139
gggtgctcct tccatctaca atg 23
<210> SEQ ID NO 140
<211> LENGTH: 20
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_74707 right PCR primer
<400> SEQUENCE: 140
ggcgttctgc tttgggagac 20
<210> SEQ ID NO 141
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_93325 right PCR primer
<400> SEQUENCE: 141
ctccatgagg tggaggtgaa gac 23
<210> SEQ ID NO 142
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_101161 right PCR primer
<400> SEQUENCE: 142
gttgaagtga gcagaggaca tgc 23
<210> SEQ ID NO 143
<211> LENGTH: 24
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_101251 right PCR primer
<400> SEQUENCE: 143
tgtctgtggg tattctttgt tgcc 24
<210> SEQ ID NO 144
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_69214 right PCR primer
<400> SEQUENCE: 144
atgcctagcc agtcaggaat cag 23
<210> SEQ ID NO 145
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_88517 right PCR primer
<400> SEQUENCE: 145
ggtgttacct cctttcatgg tgc 23
<210> SEQ ID NO 146
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_103824 right PCR primer
<400> SEQUENCE: 146
aaacgtccgc tactcttgag cac 23
<210> SEQ ID NO 147
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_108445 right PCR primer
<400> SEQUENCE: 147
ataacacttg cacaccacca ccc 23
<210> SEQ ID NO 148
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_02210 right PCR primer
<400> SEQUENCE: 148
agagggaagc cacagaaaga agc 23
<210> SEQ ID NO 149
<211> LENGTH: 21
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_103872 right PCR primer
<400> SEQUENCE: 149
agggatggac caagagggaa c 21
<210> SEQ ID NO 150
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_56412 right PCR primer
<400> SEQUENCE: 150
taactccacc ctgtacctgg ctc 23
<210> SEQ ID NO 151
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_18292 right PCR primer
<400> SEQUENCE: 151
ttagtgacca ggtgatggtg gtg 23
<210> SEQ ID NO 152
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_12075 right PCR primer
<400> SEQUENCE: 152
ctcaggaatt gcagccttga gac 23
<210> SEQ ID NO 153
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_22519 right PCR primer
<400> SEQUENCE: 153
atcctgcaat gtttggatga tgg 23
<210> SEQ ID NO 154
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_29531 right PCR primer
<400> SEQUENCE: 154
tcaccctctt aatgtcagct ccc 23
<210> SEQ ID NO 155
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_58853 right PCR primer
<400> SEQUENCE: 155
caggctgttc tctcctagca atg 23
<210> SEQ ID NO 156
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_35052 right PCR primer
<400> SEQUENCE: 156
ggcatcaaac tgaaatcctc ctg 23
<210> SEQ ID NO 157
<211> LENGTH: 24
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_67002 right PCR primer
<400> SEQUENCE: 157
cagtccgatt tcaaggtccc agtg 24
<210> SEQ ID NO 158
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_45580 right PCR primer
<400> SEQUENCE: 158
cagggcagtc actgagaatg agg 23
<210> SEQ ID NO 159
<211> LENGTH: 23
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_12646 right PCR primer
<400> SEQUENCE: 159
tttctcctct ttcatgcctc acc 23
<210> SEQ ID NO 160
<211> LENGTH: 533
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_00681 amplicon
<400> SEQUENCE: 160
agatcgccga gctgtcgtag taggtcgctt tttgcatcgc gttgtttcac gatcttgatc 60
gcacactctg acaggggttt gacacccgtg agggcgcaca ttggcacgcc cccgcggtca 120
cgtgacactc cgccgccaat ggccgccccg cgcagacctg gtggggcgag aagcgcagcg 180
cggtgagggc tccgcgcaaa tccatcttac tctcaatagc taagtgacat gaaagccata 240
aaagaaaaag tggtcagcaa tatttagcag cacgacttgg ccccgggcgc agggagccgt 300
gctataaaaa accgctggaa tttactggca gctacaaata tttgcttaac ttgcgtctgg 360
agttggggga ttttccgggg agaaggagaa tgagtgaggg ctgcaagctg attctcagga 420
gccgggatcc aaaaggagaa aggcttgata ggctagaaag gaaaaaggct gggatctttc 480
ttttccaggg aagaagaaac ttggggtgtc gcttagtttc tgctccttgg cct 533
<210> SEQ ID NO 161
<211> LENGTH: 535
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_39189 amplicon
<400> SEQUENCE: 161
cgttctcgat ccagttccat ctcgcacttc ccaaagcgtc gcagcgagtg gggaccgcag 60
ggaccaggcg ccgcgaagcg ggagcgtgag gcgctctctc cgaagccctg ggcgacgctg 120
gactagtgtg ccccggaagg acaggtcaca cccgggggtg ggggtgaaga cgacggtggc 180
ggtggggagg acacctttag cagctgggac ctgatttctt cctccacaag gctgcagctg 240
gctatggccc tggtggaaag aaaaagcgag cttgaccaac tcgacttggg aagggggata 300
gagagagaaa agaaggacct tgtgtttgta ttcataccgg tgagcaccaa agaatagtct 360
cacgcagtta taggacccag gttcagcgat gtgactactt gtccaaggtc acacagcgag 420
ctggggactc ggggaccagt gtcggatctc ccacccggtt gggacttctg agcgcacagg 480
ggcaagatat gtgagtaaac cctgtccaga atcccagtcc tttgtatcac tcggt 535
<210> SEQ ID NO 162
<211> LENGTH: 451
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_00644 amplicon
<400> SEQUENCE: 162
tatcatcatt agacccggga tggagcggcg ggggggagtt tctctttact taccaaaccg 60
caacaacaaa caaacaacga cgaacaaccg ccccctacaa acactcattc tcacacaacg 120
ttgccctacc tccctcgccg cttgccctgg ccgctgttgc acactcccct gggggctgtc 180
tgcacgccct agagcagaca ctgcggtcac ttaaagtgcg cccagttcct ccaccgcagc 240
ggtcacaccg ttgatttgat ccagaaataa gacggatagt accgagcgtt ggcgctaggg 300
gttgtctatg tcaaaggcga aggttggctg ggaagttctg tccgtttctc ttgccttagc 360
ataggagtca atccttttct tgtcacccga ttctgcaaat tctcgctgta ttaaaggagc 420
agagatctgg catgtagtgc tccattaacc c 451
<210> SEQ ID NO 163
<211> LENGTH: 464
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_81674 amplicon
<400> SEQUENCE: 163
ttcggtctcc tccccatttt cctagtcgtc ttcggttgtg gatgttgtaa actcgaccat 60
ccgtctctca aggtctttgg cttcaaggtt tcccaatgct ctggagctgt ccaagccccg 120
gtactccggg gtggaagacc tcagattcat ttgacgggct tgtggaggtt gggggtctgc 180
ggagccccgt gtgggtgggg ctgggcgcgg ccggggcgga gccggcgagg agccctaggg 240
aaagggtgaa aggcacagtt gagaaaggcc cgccgggcat tggtttcaca gtttccacga 300
aggcttcgtg tgcaagcctg aggagtttag gtgcctccct cctgcctcgc ctttcttggt 360
tctagaacct tcagtaggct tttctgggtt gcagggaccc ggaaaagcag cggcttccac 420
tcggggggcg ggtcccaagg gtcttgctgc tgctctgggg ccgt 464
<210> SEQ ID NO 164
<211> LENGTH: 505
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_81149 amplicon
<400> SEQUENCE: 164
gcaaataggt caatgctggg aacagatgcc tgcctggctg agtgctggga aagaaaggca 60
gttggaggga tgtgtgggtg cctgggaggg cgtgggtggt gcccaggagg ctatgggaat 120
cagaatcaca cttgcacaag agaagaccct tatgggacaa gtaaaatcag catagtttct 180
tgggcggggc aaaggtgtcc tgatgaggat gctaggggtc aaatatgtgt ctgggttctg 240
ccccaatcgg gaatgagaca cagtactgaa gtggaacggg ggtagcatct ccacccacct 300
tcacagcctc tggggaaaag aaagctttcc ttgcagccca actccagggg cctaaatatt 360
gagcaccaac acaagacagg tccttgagct tctcggagcg agtcggggaa gcagataatt 420
tcagatgcaa agtgccttga ataaacagaa cgaaagatag agagccagag ggggagaaac 480
ggcttggtgt ggtcagggca ggcat 505
<210> SEQ ID NO 165
<211> LENGTH: 425
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_83841 amplicon
<400> SEQUENCE: 165
aagttcccaa gcacgaagtg ttctgcgtcc cgaacattcc aggggccgcc agccaccatg 60
ggctctgtcc tgaggtgcca agcaggacat ccctgcccga catccttgtc ctcccgcacc 120
gcacacgcgt tagtggctgt ggcgtcgcca ccccagcaca cgctggcccg cccgcagtgc 180
caggctggaa gtgtcgggcg cttgccaggc caaggggcaa ttctgttgcc ttccaggcct 240
tttcggcgcg gtcccagtca ggaacgcgcc ctgtcgcctc ccactccgtc ttccggaccc 300
tcccgatcct ctctcgtcag cgatcgggcg tcgctcccct ggactaacct cccttgcccc 360
atcttcagct tttcgctgat ctgcatcttc ctgcgcctta gtgcaaggca gagacctggt 420
tctaa 425
<210> SEQ ID NO 166
<211> LENGTH: 585
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_38705 amplicon
<400> SEQUENCE: 166
tccaggtagt cgtttctgaa gccctagtcc tcagttccca aagaaaccac gtgcgcacta 60
ccacctaaaa ctgccaatga aaatgaaggt cctgcgcagt aaaatattta tacaactgct 120
ggggccacta ggcttcagcg ggtgtggagg cggggagaga ggaggagtaa aggctgttta 180
caaacttgac gtacacacgc agtcctatcc ctacggtcct ggaattgggg gttactatct 240
tggaatctag gggcactcca ggctctgggc tcagacggct ggcttctgcc tacccgagcc 300
ttaacctttc aaggaccaga aggattccag agctcttgcc ctaggtcctg gggcagcgat 360
gactcactgc agcaccccct cccacttcgc caagctgccg tctccgccca cccccaaaca 420
atctcgacag cgcatttcgg gagccacggc tccgggcgct ttgctggggg ctaaaggggt 480
ttatcccttt ccttgaatcc cagcaggcta gaactacccc ctcccagtct tcaggcttgc 540
cacgctctcc acccgatcct tccattgaaa ggcagagaag gaagg 585
<210> SEQ ID NO 167
<211> LENGTH: 407
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_40164 amplicon
<400> SEQUENCE: 167
gcccgccctg caaccaaccc gctcaaacaa gcaccctgac tggcgcattc ttactcattc 60
tagcctgggt ttcaacttca aggagcttca gcgcccctca ctcccttgcc ctgaaagctg 120
gctaaactac gcaccttttc tccccttttg aaatgacctt tccagatatt tctatggaat 180
tcagtgccat tttctgccgc tgttctcacc acattcattc atcatgttta gttttaaaag 240
taccagattc tgtcgatttc tccaactgaa ctctgaaatc tttgaggtca gggagcttgc 300
ctcattctat tttgtattcc cagtacgtga cacatggctg gacacaccag aaattgtccg 360
atcaagtttg tgggtattaa gagtggtcaa agacgctggg gagggca 407
<210> SEQ ID NO 168
<211> LENGTH: 526
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_23178 amplicon
<400> SEQUENCE: 168
ttctcagagt gttggtaccg cagattcaac tggggccaga gaagcccatc acgggagccc 60
gaggaaaagc agccacagct ctccttccta gtacaagcat tcaacagtaa gctcccacgc 120
aaagaatcag actgcagcaa atttcagcgc tgcctcagga acactgtcct tggctcccac 180
attgcaaaga ttttccattc cctccacagt cacctcattc atggttaagg aagaaagcgc 240
agctaacaga cagggtgacg acagatgtcc aggcactgag ccatccatag ctgttatttt 300
tcattcacat aggcatgtgc cggatccagc agatgaaaac cagacctacc cccttcccca 360
tgtgtgtgtg ttttttcccc ttactgctgc tgctgtaaca gctaagtgcc aattatctcc 420
caagcgtgaa agcaaatatt gtgatagccc aacaaactct acaaatgtta gaggacacag 480
gtggggatga ctgtttttct gtcctggcct tggcatgtct ttattc 526
<210> SEQ ID NO 169
<211> LENGTH: 404
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_46057 amplicon
<400> SEQUENCE: 169
ggttgccagg acacaaagta agcaacagct gcatgaccgg tttagtcctg acgtttacaa 60
agagggaccc tttccataag cctgtaactt ggtgtgggca gcttgccgat gtcaggcagt 120
gcatgtttca ctcgattagg gagagagcgc accctctcca gagggctttg gccacgctta 180
attttttctt tgtttccttc tatactgctt tatatctcac acatcccctc ttaactctcc 240
agacatggga agttgttgtg acaggtcagg aaagtcgtat gtttaccctt ctcctagaaa 300
ttagttatgt aagctattat tgtatgtatt tagtaatgag gggacatgtg cattaatctc 360
ttaaagcttt gaaataatta gcagcatggt cttatgcttc catg 404
<210> SEQ ID NO 170
<211> LENGTH: 512
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_40959 amplicon
<400> SEQUENCE: 170
tcagttgaga gctcagagca agctgttgga ttaagcaaaa gcacctttta aaaaattaat 60
attcaaggca gctgtaccgc ggagggcctg ggtctcggag tctaaaaaat cagactggac 120
gttactattt ttttttaggc aaacgacagc tcgtttctca tttgtaaaac cgggggaaca 180
tcttaccgaa taaaccttac acaaacagaa aggattccta agggctggga aaatactatt 240
ttgctgtccc caggatggaa tatcagcatc cttgtctttt agctcttaat aaagctctaa 300
ctagtcacag gaggagccag gctgcatgat cacgcacact ctggacgtct aggttttccg 360
acctaataag ggggcaggtc gcgtcgttcc ctgcttaaat tagagaccac ctccacctgc 420
caagggccct tcaaaccctc cgcccctagg tcgctaacga tcaccgcttt agttctagct 480
ccaggcgccg cctggcggct gtctccggaa gt 512
<210> SEQ ID NO 171
<211> LENGTH: 413
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_104423 amplicon
<400> SEQUENCE: 171
tgatctgttt cctcactcgc ttgctcgtgg atgtcatttt ctgtcttctt gggggcggcc 60
aaaaatcgac cggtgtcggg gaccagaggc ggccccgcac gcccccgcgt gtgcgtccac 120
gggcgtctgt gcagacggac actgtgccgg ggcgagctga caggagttca cggctgcgat 180
agaacatgga gatgtcatgg gcgcgacaga gcctggcggg gataccagca gcgtgtgtgt 240
gtggacggca acgttgtctg tgcgcgtgtg tgtgagtgag tgagggagag agagagagaa 300
taggtgtgtg tagaggctcc cggtgcctct gtctggctgc tgaggctgag atgggagcaa 360
gtggctggcg aagctggtgg tggcttcaaa ccacactttc gtagaacaat cgc 413
<210> SEQ ID NO 172
<211> LENGTH: 560
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_00847 amplicon
<400> SEQUENCE: 172
atgggtggat ggatggatag atgaatgggt ggatggatgg agggatggat ggacggacgg 60
acggacagat atatggatgg atgcattatg gatggatgca tggacggacg gacggatgca 120
cggagagatg gatggatgca tggatggata gatagacgga tggacggacg gatagataga 180
tggatgccgg aaaggagaag aatgagagac ggatgtgaga ctagatgcac gcaggccaga 240
gcaccagcat acgctggaac agagcacgag catacactcg aacacacgcg cacacactca 300
ggacatctgc gcacagacat acaatcctcc gcgtccgctt ccacgcaggc attcgcgcac 360
ctacatacac gcagttgcac gcgcgcgcac acacacaggc acacacacgc agacatgcac 420
acacacgcag acatgcacac acaccacaca tgcagacatg cacacacacg cagacatgca 480
cacacacacc acacatacac acacacacac acacagttcg cctctccctg ggtttctcag 540
aaactaaatg atcaccgccc 560
<210> SEQ ID NO 173
<211> LENGTH: 430
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_08347 amplicon
<400> SEQUENCE: 173
ggaggactgc cccatatttt cactcccaaa aaccccttag atgactccct gcctcacccc 60
cgccccccag gttctgaaag agccttcccg ccagactgca ttgattaacc attcattgcc 120
ccatttttta ttaatcaaag acatatataa ttgctcatcg gagcttgtga tcagcgtgag 180
gccttactaa gcagctgcct tactatcctt ccagcccaga gcacgtgagc tgacgtcttc 240
tttggcctgt gtggccgttt ccttgccaaa agctcagttt ggggagagct tcttgcgtat 300
tagatgcagt ctgcagactc ccaaccccag ctacctggat cccctgaggg cccaggaact 360
ccagctattc caagcccact cctctttttt ttaagaggaa gaaatagagg ttacgatagg 420
ggacagccag 430
<210> SEQ ID NO 174
<211> LENGTH: 407
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_02416 amplicon
<400> SEQUENCE: 174
gcgccccggg acgaggtgga cggccggggg gagctggtaa ggaggagcag cggcggtgcc 60
agcagcagca agagccccgg gccggtgaaa gtgcgggaac agctgtgcaa gctgaaaggc 120
ggggtggtgg tagacgagct gggctgcagc cgccaacggg ccccttccag caaacaggtg 180
aatggggtgc agaagcagag acggctagca gccaacgcca gggagcggcg caggatgcat 240
gggctgaacc acgccttcga ccagctgcgc aatgttatcc cgtcgttcaa caacgacaag 300
aagctgtcca aatatgagac cctgcagatg gcccaaatct acatcaacgc cttgtccgag 360
ctgctacaaa cgcccagcgg aggggaacag ccaccgccgc ctccagc 407
<210> SEQ ID NO 175
<211> LENGTH: 542
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_87540 amplicon
<400> SEQUENCE: 175
gttaatggag ggtgagggtt tccacccgtg ggtctctgaa agggctccca caggttcagc 60
aagagcgtct gggagaaacc atctgtggag tgggggacac aggcacagag tgtcccgtcc 120
tgggcaaggg gtcccctcct ctcgctgctc cctgccaaga gcccagaggg aagaaaggac 180
catggcatga gcatctatgt atgaagtctc ctctgatccc taggaggagg gatggggcgt 240
gtgttgtgtg tgtccacgcg tgtgcacagt ggaactgatg aggtgtgtga agagagaagg 300
gtgttcctgt ctccctgaat tgcctcccat gccctggctt ctcccctggc ttctccctcc 360
cacctggttg cccatcaccc ttactcacat ttctcaaggc ccgtgttgaa tcctgggctc 420
tcccgacagc gtcttcgtgc actgtgtgca gagggagccc gcgtcatgca cagcagggag 480
gggagggttt tctgtggagt ggagggggga ccattcccgg aggaatgttg gagggaatga 540
ac 542
<210> SEQ ID NO 176
<211> LENGTH: 432
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_110107 amplicon
<400> SEQUENCE: 176
gctgggtgaa tagtcacgga atctcactca cgctcggctc ctccacccat cccgtctaca 60
gcgcgtgtcc cagtccaggg cgtgcgtgcg ctcggtgtcc gattccgggc tgtgtgtgtc 120
catttggcga gatgtcgaga gcggggggag tgtccttgtc ggtgtatctg ggcccaggtt 180
aggggacttc tcctccccac ccccgcgtgg gtgtgggggt gtgtccgggc tagggcgcgt 240
gtgcttctgt gcctgtgcgt gcgtgtgcgg gtcagggtgg tgggaccgcg catcagggca 300
gggtgcctgc gtctgcgtct gggtctgtct ggtctgcatg tcggcgcgat ctcgacctgg 360
attcgtgtcc ctggatgtcg agaggccagc gtggtggggg tgtccagcct cccggaggag 420
tactatgcct tg 432
<210> SEQ ID NO 177
<211> LENGTH: 472
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_89799 amplicon
<400> SEQUENCE: 177
aacgctcttc ctccaaagag gtcgcgcctt ctctgtggtg gttctcaggg atccgcccca 60
gctccttctc cgttcccagc cccacacact gggatcacca ggcacccaag atcccacctc 120
tcaggtggta tcttcagcgc aggctgccac tcagcccccc tccagggatc tggggcagaa 180
ggcgaatatc ccagagtctc agagtccaca ggagttactc tgaagggcga ggcgcgggct 240
gcatcagtgg acccccacac cccacccgca ccccaagcgc tccaccctgg gggcggggcc 300
gtcgccttcc ttccggactc gggatcgatc tggaactccg ggaatttccc tggcccgggg 360
gctccgggct ttccagcccc aaccatgcat aaaaggggtt cgcggatctc ggagagccac 420
agagcccggg ccgcaggcac ctcctcgcca gctcttccgc tcctctcaca gc 472
<210> SEQ ID NO 178
<211> LENGTH: 600
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_45173 amplicon
<400> SEQUENCE: 178
gttcttctaa gcttcattcc acaagagatt gaaatcgaag tattctgggc tggcacacga 60
tagctggaac atcatatttt attctagaaa cacatttgcc ttggcaaaga agagcgtgcc 120
tagaggagtg gtcaggatag tgagggatct gtgatccttc gttctgaatc tagaaaagtc 180
actggatatg cccctccccc gccccccaac acggtcttat gttctgaatg tagaagtcac 240
tggatgtgct gacacacaca cacacacaca cacacacaca cacacacaca cacacacaca 300
cacacagagt ctgtggcctc tttcccaggc attccaagtc cagcaagttc gcagggagct 360
gtcagtccgt ccaggaaggc ccgggcctgg gtttgcctct tcaagcagct actgcagggg 420
cgtggggagg gggcataaga gactttggac tttcctttga gacagtagaa agcgttacat 480
ccagaggcga gattctagcc tggggtcccc gccttcccgg cctcctcttc ctctccctct 540
gactcccttt cctgtgcccc tccccctgcc tctttcccgg ccagagtcca gccttaaccc 600
<210> SEQ ID NO 179
<211> LENGTH: 410
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_80771 amplicon
<400> SEQUENCE: 179
ggtgaaatat gtgcggactg atgagtcaaa gctcttattc cctggactgc attaataccc 60
acgacgtgct tttcgctctc cagacaaaga gaccggtact tggcaggtcc ctcaagtggg 120
actcaaaaga ccgaaccgag ctgcagcctt tcgctagcac tggtcctcgc cccttttggc 180
atcttggtac ttgtagtttt gtccactcta tctttacccg aaaagccagc gctgagacca 240
caactcccat caccctgcga gcaccagcgc cttcagagcg catcctccga ggggcaccag 300
cgccattgac caccctgctg gccgaagggc ccgccttccc gaggccaggc gctcccgcga 360
ttggccagcc gccccgcctc tcatcggagg gcgccaggtg aatgaaaggg 410
<210> SEQ ID NO 180
<211> LENGTH: 409
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_69407 amplicon
<400> SEQUENCE: 180
ctcattcatg cataggtcac acttctccaa agttggtatg gcctgtctcc ttggcatgtt 60
cccttgcttc tgcttgtcca gttaatcctt tctgacatac catgcatctc agggtgaagc 120
ggttgacatc agtaaactgt ctccttcttc tagcttcatc tgctaattcc agtgcttgta 180
caagaacaat atcatcatta gaggagaaaa tggtcagagg aggtgtatct ggatcaggga 240
agttacgctg aagtggatca tagtggatgc catcataaat aagcagaacc cttttggtat 300
atcctgcatc ttccccaaaa cgatcaattc ttactgtctg tgtatccact acacatattt 360
cacattggta aaacttggac aaaatcgata tctctattgc tcctcccca 409
<210> SEQ ID NO 181
<211> LENGTH: 411
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_05406 amplicon
<400> SEQUENCE: 181
ctccttccca ctaggctgca gaggcgggga agacccgcca caggctggcg tgcggagccc 60
caggccggcg gccttccgtg attaacgagt gtttacaaga ctctattagt aatgacacag 120
acaccaatgg ttggagacgt cgaggcgcag cgcgcactct acgcacaacc cctcgaaaca 180
taatttgcat tttaaaagat aaaggggagg gaggctcgtg agagggcagc gacctgacac 240
agctaaatat tcaaaccttt attgttaaga gcttcctcct tccaacctgg tgcactttaa 300
cctccaatca caggttcaaa gaatgaaatc aagagactta caaaagagag gggaagagaa 360
aaggctatct tggtaggaat ctgagcttgg agacaggagc agtggttgtt t 411
<210> SEQ ID NO 182
<211> LENGTH: 488
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_80287 amplicon
<400> SEQUENCE: 182
aggcctggga ggtgactcat agagtctgcc ccctctcgcc cttctgccct gggaggtcgg 60
gggtgaggat ggtggagggg aagcgtgcga agggggtgcc agggttagaa tgaggtgccc 120
accgaggaga gagacgtctg aagtctggcg tcttttcctt caaggctgct gtgtagattg 180
tgaggtggga gggctgaaga tcaagttccc tcgagggagg ttaaagaagg gctaagtgga 240
cccggaaact ctgctcttcg gggtggtctc cgctctggga ggcggggact cccctctggt 300
atgggtgttc attgttctgg ccccattgga atctatcccc cagggacaac tcctttgtgc 360
aaagtcctgc aggatagaag agggggcagt gcacaatcaa tttcaccgtc aaaggggaca 420
tgtctggttt tatgaaggga gagggaagaa gaaaggatca agtggggatg ggttaggcac 480
acacctta 488
<210> SEQ ID NO 183
<211> LENGTH: 599
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_02345 amplicon
<400> SEQUENCE: 183
gtagatgcgg aaattggcct cagccgcgcc atgcagcgcg ccctcgtccg tcttgtcgca 60
ggcgcctttg gcgaggtcac tgcagagccc ggggatgttt tggtcgtagg aggcgcaggg 120
caggttgccg taggcgtcgg cgcccaggcc gtagccggac gcaaaggggc tctgataaag 180
ggggctgttg acattgtata agcccggaac ggtcgaggcg aaggcgccgg cgcccgcccc 240
gtagccgctt ctctgtgagt tgggagcaaa ggagcaagaa gtcggctcgg cattttggaa 300
cagagaagcc cccgccgtat atttgctaaa aagcgcgttc acataatacg aagaactcat 360
aattttgacc tgtgatttgt tgtccggcag ctttcagtgt cggttttacg aggtagagtg 420
atatatgata acattacacc cccagattta caccaaaccc cattttcttt tggacggagc 480
tcgccgcagc acgtgaccgc ccacatgacc gcctccgcca atctcagcag tcctcacagg 540
tggtctcgct ccgcagggcc cgcagccgcc tagaatggaa gggcaagagg ctcaaatat 599
<210> SEQ ID NO 184
<211> LENGTH: 584
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_36172 amplicon
<400> SEQUENCE: 184
cctagacagc aacacaccca ctggaaacgc acgtgaacaa agctctcgcc cccgggagcc 60
gctgcctgcg gtttcctagt cgatcccagc ttctctaggg agtgtcaggc gcacacaggg 120
ttaagttagt tccctccctg gtaggaggga gaggaggagg aggggaaaag cagcatactg 180
tctcaggctg ggtaccttgt agttagttgt acgttcgaaa cctgtcgccg tcacttgcgc 240
gtttggcatt atccattgtc accgcggagg aacgagcgct cgagatatca tcagtgcccg 300
caaatctccg cgccaaggcg ctgagctact cctttccgag gtgcgcctct ggtcctccgt 360
ccctggtgcc cagcagcggc gaggcggcat ctccgctccc gccgccgtgt ccaccgagcc 420
ctgggatcag ggtggcagtt ctcaacgatg ggcaggaggg acctcggcgg cgacccctaa 480
aacaatacca tgccccggga tccccgctgc tgccgcgcca gcgtcttccc tttccacctc 540
cctgaccctg tcggattcgg atgagcccat tgcaaggaga agac 584
<210> SEQ ID NO 185
<211> LENGTH: 400
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_70459 amplicon
<400> SEQUENCE: 185
ttcaccgtct ctactttctt ccttctaaga gatcctgaaa cctctgtcat ggaaaagtac 60
cacgtgttgg agatgattgg agaaggctct tttgggaggg tgtacaaggg tcgaagaaaa 120
tacagtgctc aggtgttgca caaagaggga taccttttgg gtgggatttg gtacccccaa 180
ctccagtgga aaatggatct agaaggaatg tatttatacc agtttgtatt cctaaggtac 240
tgactccctc atacttctta tggagtataa gctttgaagt tggattattt gggtgcaaat 300
tccatctcca ccgctttcta gccctagaat tatggacaaa ttacttaact tccctatgtc 360
tcaatttcct tatctctaga atggggataa gaacagcaac 400
<210> SEQ ID NO 186
<211> LENGTH: 408
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarrayfeature identifier
ha1p_105937 amplicon
<400> SEQUENCE: 186
ctctaaacac tcgcctctac ccgccgcccc gcgaacccca cacactgcag acgcgacact 60
cgcaagtttc ggggatggcg gccggcgagg gccatactgc gtctttccgg agacacggaa 120
tacggcacca gccgtccctt tatgatgcaa tatgtctgcg cccaggggac gcttgctggg 180
agcagccatt ttcaacccta ctgccgtaga gcaggcggag tccctctttt cgcgccttaa 240
gacaggtagg ttctgacgat gaaaagcaat tgaaaacgac ccatttcacc ctttttccag 300
tccacgtgaa ctgctagatc ttggctttgc aacattagcc aggggcgcta cataaactgc 360
ttagtttctc aaaggctcaa gcctgccctg atctgtctac aggatggg 408
<210> SEQ ID NO 187
<211> LENGTH: 591
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_89099 amplicon
<400> SEQUENCE: 187
tagcccttga cagcagttgt gacggggagg attggaccgc ccggattagg gctaattaag 60
ggtggatggg tggcgggcgg ggaagtgcgg gtggctaaat aggtgcctga taactcagtt 120
aacttccctc ttggcttttc cctttgacct taacactttt ggggttatct ctgaggcgaa 180
tgctaaagga gacgctccag gactcgacct ctgaaggtcc ttggagccaa ttccgtaata 240
tgatcatgga aactgatcat tgcctgatcc ttctaccgcc ttggcgcgct ttcttgagga 300
atgtctttgg ttaatggctt cacggccatg gaggtgacat catgtggaca acaggctagg 360
atgccagagt tagctgctcg gtggagatca tttgaggtca gcagaggcca cgatattata 420
gatactaaca gaccccgata tggggagaaa agcaaaagca ggagcctgaa tatccagtgc 480
tttgtgagct gtcagttctg tgtgtaatgg caggaaatcc aagtcttaac tgcgccctta 540
ctatgaaggc tttccgagcc agccacagct tctgggtcat gggcattagt c 591
<210> SEQ ID NO 188
<211> LENGTH: 470
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_03099 amplicon
<400> SEQUENCE: 188
agagccacgt gagctgcatt aaccccgtga actggccggc gcgcagctcc gagaggctgt 60
tgtagcgcag ggacaagccc agcaggccgg acaggttgtg gggcgcctcg gtgaggttga 120
gcgcctcgca gtacagcagc cgcccctcgc accggcacag ctgcgggcac ccgctggggg 180
cggcgggcag catctgaaag caggccccca gcagacacaa gaccaccccc gagggcctcc 240
tcagcagcca gtatagacag agaccgagca gcaggaaatc cattagcgag aatctttcca 300
gagagactgg agaatgtcca ttggaagcgc tcggtcagaa atctacatca tattttattc 360
cgagggaggg gaagcggggg agggggagaa aagggcaaaa aatcaaataa atacatagaa 420
ataaagaagg acccccctcc ccaaaaacca cacgttcacc tctaagcatg 470
<210> SEQ ID NO 189
<211> LENGTH: 426
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_67625 amplicon
<400> SEQUENCE: 189
cctggagtcc tagagagcct cgccgcaccc cctccccttc tccgtcccct cctctcctca 60
gagccggctg agcctccctc cctgccctgc gcttcccacg gggagagaag gaaaaacagg 120
aggggggagg aaggaccagg aaggggagag aggagtggag gggtactgtt tggagcggtc 180
cgcgcgcccc cgcccctcgc gctctcgcga cgaaggctcc tcgagcccag ccgggtacaa 240
caagtctgtc ctccgacgtc agggggtcat taataaccaa ttaggagggt cactgcggct 300
cctataaagg cgctgagatt ttgccaaggg gaagacggcc ccggccgagt gtgcgagagg 360
ctagcgcgcg cctgagcccc ttgctgccgc ttccctgcaa ccacccgcct ctcacccacc 420
ctgcac 426
<210> SEQ ID NO 190
<211> LENGTH: 407
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_00218 amplicon
<400> SEQUENCE: 190
gccgcgccac cccacctgag tccgccggcc agcgcgggga cgcaccgggc agcgtgtgtt 60
tggcgaccct cccgcacctc tggtctcagt tgcgtgtgtg cacgaggggt tccatagggc 120
ccagggatgc ttggtaccca cgggggagaa tccctcgccg aaccctgcgg gtctgcgggg 180
cgggccgcga gactggcgcg caaaagcggc tccaaggcgg ggctcccgcg ctccccgggg 240
ccggcttgcc gagtccaagt tgagcaaccg gcgtcgagag agacaccgcc cctgctgcgg 300
gcgggggcct ctcctcgctt ccgattggct gacgggggga acctatcgcc gtcggccgcc 360
tccgccagag cggtttgctg gttttcattc attggccccg gagccgc 407
<210> SEQ ID NO 191
<211> LENGTH: 497
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_12535 amplicon
<400> SEQUENCE: 191
agtgttgggt gctgggagga ggggccatag gaccctgggc gggagcagag gtacccaggg 60
ctgcggggcg ctcaggtgag gccgggagat cttcctacgg gaggctgaga cgggagctgg 120
ctttgccctc tctgactgca cgcggggagc ctgattaaaa gcctggcctg aggagaagga 180
ggagttggtg atgggaggag aaagggagcc tccctccact ccgcacgcaa cactcctcgt 240
ttatctcctt tcctctccgt ttgctccagg tgatcacagg ttggaaagct tattatcttt 300
tgcaactaca ggctactgga aaaagttttc ctcttcctat gatccccgtc atggtgaatt 360
cagcgacata agcagctcct gagctactgg aaaaagtttt cctcttcctg tgatccccac 420
gatggtgaat tcagcaacat aaatagctcc tgcgcacacg ccaggcaggg atggcgaaga 480
acacacaaga accctca 497
<210> SEQ ID NO 192
<211> LENGTH: 590
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_105474 amplicon
<400> SEQUENCE: 192
ctctgggctt tctctagctt ccccagggaa gggaggctcg gggtgaggtg ggcacggggc 60
atctttcctg cccaactgtg aagtcctaaa aagcttcaca aagtttctat tgaatgacag 120
ctttcttctt ctctttctcc agggttgagt tccagaataa attctacagc gggaccggtt 180
tcaagttctt acccttctcc ttcgagcata ttcgggaagg gaagtttgaa gagtgagtcc 240
ctgtgagggc cgtgtgcccc atgctaccct ccccgcctcc ctccacagtg atcagctgtg 300
cctctctgcc tgttggttgt gatctgtggg caccagctca ttcgtgtcac cctgtctgtg 360
agtcatttag atagaatagt cctccttggg tctcccacca cccctagctt tgtgtgtagt 420
gtagtgattt tctggctgtc actcatactc actgggcacc agccttgccc tcttagcctc 480
catccatcca gacagccctt cccacctcct ggtggtgagc cagtctgcat tcccacgcca 540
tcccaaagcc ctttcatctt ccccgtgcat tgtagatgga aggagcaccc 590
<210> SEQ ID NO 193
<211> LENGTH: 489
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_74707 amplicon
<400> SEQUENCE: 193
agtttgtgag ctcaggagaa gcgctccgag ctcggcatct ggagcagttc aaggcagcag 60
cgagcaagtc caaagacgca ggagggaggg tggggtggag gagtagagag aaaacagaag 120
ccgtctacag accctttttc cctctggggc aactaaacct caagtgcagg aagcgcttgg 180
ggactgccca gccctcagct gtgttattat tcggtgatag gtatttgcta attacttcca 240
aaagcctccc atctgtcatc ccacccagac tgcgcgcttc taattcctcc taccccacat 300
gctgtgccca atgaaaagta tggtcagcga gcgaaggttt gcaaggagac agacgagggc 360
gaaattaagc caggcggctt ccctttaaat cctcgcaaag cagaagggcc cctcactctg 420
gcagcaggcc ttggccaagg ggcctttagc cctgacgacc cggggaagag tctcccaaag 480
cagaacgcc 489
<210> SEQ ID NO 194
<211> LENGTH: 567
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_93325 amplicon
<400> SEQUENCE: 194
ccagtcccat agtggaaatg ctctcgtatc cagacgtgca ccgtctccag tcagcagctg 60
aaaataactc gttcttgaaa ggagaaagcc aaccgccccc tttctcctgc acaactgact 120
gagggcttga aggaggcttg tataaggctg agggattttt ccaagaagga agaatggcgt 180
aatgctgcct gtgtgctcca gttttttttt ccccctagtt ttgaatcctt tccagtgaaa 240
atacttcaca cacacacaca cacacacaca cacacacaca cacacacaca ctcacaggcc 300
tgcaggtgct cagaaaaatc ttttacaaac ctgaactcag gaattggaaa cggaattcca 360
acccaaacca atttaattac tctctgatgt catgctgtct aaactcattt aagtgcgata 420
tatttatgtg aaaaaaatca ccgctgccct ttcgaggcca tggctcacgg gggctcctgg 480
cacagagccc tgcagcggga ctctaggctt agggggcctc cccctccacg gggcagactc 540
aggggtcttc acctccacct catggag 567
<210> SEQ ID NO 195
<211> LENGTH: 460
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_101161 amplicon
<400> SEQUENCE: 195
actaccttgg gtgtcagtcc tgcttcaaga ctccagagag ataaagagag atgacctcag 60
agacaaagag actcagaccc agccagaggc ccaatggaca gtgggagggg tgggtggaag 120
aaggctggtc tctgtctgac caagcccccc cagaataacg caggctgccc ccctaggtgg 180
aaacaatgac acaatcagct cccaatacca agggcctgac atcacaaggg gaggggaagg 240
cagctgaggt tgtgggggga ggtgccccgc cccttggcag gcccctacag ccaatggaac 300
ggccctggaa gagacccggg tcgcctccgg agcttcaaaa acatgtgagg agggaagagt 360
gtgcagacgg aacttcagcc gctgcctctg ttctcagcgt cagtgccgcc actgcccccg 420
ccagagccca ccggccagca tgtcctctgc tcacttcaac 460
<210> SEQ ID NO 196
<211> LENGTH: 400
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_101251 amplicon
<400> SEQUENCE: 196
tggacacatg tgctacacgc taagatgcag atgtcaggca cgcgcagccc acacacagct 60
gacacacgtc gcagggaccc tcatagacaa gcgcatcaca tacaaaggtg gacagccatc 120
agcagacggg gacacgtaca cgtcacacac aaagacgcag ggaccgcact ggaaacgcac 180
aggcaggcca gcttccagca cagatgcacc cggccacgca ggaacgtcaa agcatcacaa 240
agacccacac atgccccgga caaagtaaag ccccagatcc acagacgcac acgccacaga 300
caaagatccc cacggacacc actgtgacat gctgacactc atagtcacag ccacgcagac 360
agtccctaga caaatgggca acaaagaata cccacagaca 400
<210> SEQ ID NO 197
<211> LENGTH: 597
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_69214 amplicon
<400> SEQUENCE: 197
aggtcactgc agaaggatgg aactgacctt tattccccag tgggcagtta ctgagctttc 60
ctcctcagag ccatgctggc agccctggga cagagaacgg tgtggctttg gctgcctctg 120
catggaatct tgccccggac tcctgaagac tgcacaagga atgaggaaga tcagggacaa 180
cctgggaact gaataacttt caaagccagt gctcagcttc tctgctccgt actagcgttt 240
acaggtctta attcaaacca gatgcctgta ctagttttta gaccccaagt caacctttct 300
gagccacagc ttcccgctgg gaataatgat gcctgcccta tctacctcac agacttgtta 360
tgaggataaa gtgagattaa actgcctcaa agtgctttgt aaacctcagg tgaataggaa 420
aggggaaagt aaggctggag tgatgatggg gaggtcggag gataaggggg ggctgggatt 480
gctaatgggg actaaaatgg ccagtctcct ggcaagattt tgagcaggtc atttcattga 540
ggcctcttag atttcatatt tgagaattag ggcactgatt cctgactggc taggcat 597
<210> SEQ ID NO 198
<211> LENGTH: 527
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_88517 amplicon
<400> SEQUENCE: 198
gggactcatt caatgtcaag tgcttacaac gggggctggc gcagaggaag cccacaggtc 60
cgtgcggccg aatcccaggc atcccgacgc ccgccctctc tggcactaag cgcagccctt 120
tcccctcccc tccgtgactc tggccctccc ttcaacccgt tctccacaca gcagccgggg 180
ggagctttta agatgcgaaa gaggaggtgt cacttcggtc tccagtgact ccttggcccc 240
tgaataaagc ttaagactga acgccccact ccaggagcac cactctgacc ctcacctcag 300
gaccgcagcc acactgcttt ctctccggtc ctctatcccg ctccctcctg cccaaggcct 360
ttgcccatcg tgtcctctgc ttggtgtttt cttcctctgg ttaactccta cttattttac 420
agcgctcagc ttaagcacca cccattccag aacgcctttc ccgattttct catttatgca 480
gatctcctct ttcagaccct gagagcacca tgaaaggagg taacacc 527
<210> SEQ ID NO 199
<211> LENGTH: 591
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_103824 amplicon
<400> SEQUENCE: 199
tctttagacg ctgcgctctt agcctgtctc tcttccccac cccctcccct agctcattaa 60
gatgctcaac actcaaatcg gggtattgat ctccacggaa gccccaaacc ctcgccatcg 120
agagaccccc atggcccggg gtgatggctg tggggcttgg tgctcccaga gagctcagtg 180
gctacagaat gggtggggat tctgcgtgtc tcccggagcc tgaacccctt tcctggttat 240
ggccggtagc tgtctccagg gctaacgtgg gcagcgcagg ggggcggaaa ccgggtttta 300
gccaaatgcc tcgacatcgc cgcgcctccg cctcctcgtc gctgaaagaa atgtcggggt 360
ttcatcagag ctagggagcg acagtcggga acagcgagtc tgccgaagcc ggctgttgtg 420
tgagggtgtg agacggcggg gcggtgaggg gccaccgcgg cttgggggat agtgcgtgtg 480
gggttgaccg tgtgtctgct tgagaggctg tgaagatatg gggggcagat atgggagaaa 540
tgctcgggcc tgaagtcccc agcccaccgt gctcaagagt agcggacgtt t 591
<210> SEQ ID NO 200
<211> LENGTH: 405
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_108445 amplicon
<400> SEQUENCE: 200
catctgtctt tgttgggcag ttgcatcaga agggttaagg acagctggga acacatcctg 60
cctctagtga acctcgtggt tctgtcatct gcctgcccct cacccagcct aacccctctg 120
aaccaggagc ctgagctgca cttactgctc ccccctgccc cccggacggc ctggaccaag 180
cagcagctcc cagagcggtg gcccagcaaa cacgacttga ctcgaggcca aggctcttga 240
gggctgagca gtgtccccat gcacactcct gaaacacttt gtcccttcgc cattcagaag 300
gcatcatttt ggggaaggca gcagccggtt tttcagagcc agcgagtggc cctgccagct 360
gctgagcagg gcaagctgag aagggtggtg gtgtgcaagt gttat 405
<210> SEQ ID NO 201
<211> LENGTH: 494
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_02210 amplicon
<400> SEQUENCE: 201
cccaagtact cggcactgca cagcacctcg ccgggctcct cggctcccat cgcgccctcg 60
gccagctccc ccagcagctc gagcaacgct ggtggtggcg gcggcggcgg cggcggcggc 120
ggcggcggcg gaggccgaag cagcagctcc agcagcagtg gcagcagcgg cggcgggggc 180
tcggaggcta tgcggagagc ctgtcttcca accccaccgg tgcgtatttc tgcataatca 240
ccgcttaaag gcacattttg acagccccct ttatctgctt gatgtttttt tcatgtctgc 300
acagcaaatc accccacacc tccaaccaat tttcccctct ctctctctta agtattcagc 360
aggtcttgcc tttcatatta atttttatga cctgggatgt tgcctgtgcg cgtgttgtgt 420
tgtgtttcgt tgtgtctaca ggctcacttt cctcctcctc ctgcactctc ggcttctttc 480
tgtggcttcc ctct 494
<210> SEQ ID NO 202
<211> LENGTH: 578
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_103872 amplicon
<400> SEQUENCE: 202
tgagattcaa tttctcgccc ttcccccgct aaaatcctcc tggccccatc atttcttggg 60
tcctttccag acagtgctgt gtctttaagg aagttgaagc tgctaaaagt gagtgagaga 120
gagagaaaaa acacaaccca aaaaaatttg gcatctcttc ccccctcaag tttctggtgt 180
cacttatgaa acacaggtcc ttgttgctgc agagaagcag ttgttttgct ggaaggaggg 240
agtgcgcggg ctgccccggg ctcctccctg ccgcctcctc tcagtggatg gttccaggca 300
ccctgtctgg ggcagggagg gcacaggcct gcacatcgaa ggtggggtgg gaccaggctg 360
cccctcgccc cagcatccaa gtcctccctt gggcgcccgt ggccctgcag actctcaggg 420
ctaaggtcct ctgttgcttt ttggttccac cttagaagag gctccgcttg actaagagta 480
gcttgaaggt aagccagtgg ggaggagggc tccagggcca gcggcgggag cgggaggcct 540
gttggacata ggggctggtt ccctcttggt ccatccct 578
<210> SEQ ID NO 203
<211> LENGTH: 495
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_56412 amplicon
<400> SEQUENCE: 203
tgccggtctg ctctgctcgg cgctgtgcca gcaggcggag agctcgcgcc ttccgcgctg 60
acgtcagcgc atcccgggcc gtatcccggg agaccctgtt gcgtggtgat gggttgccag 120
ggagacatac accttttctc tgggcctggg ccgcagctgc gcggagcgcc gggcacggat 180
ggcggcggct gaggggagcg aagcgaggga gggagagcaa gctaagaaac acccagcagg 240
tgctcccccg cctaggcctg gctggaggct actggcgcca ccctgggggc cctgtcagcc 300
aggtacccaa ggggagggat cgagggtggg cctcaggtca aggggcagtg ttggctgccc 360
ttgtgaggga cgggaacgtg atagaagaga gctgggcaat gccggggagg gatgtgtgcc 420
tccaacttca ttaagtgagg gaaacatttg ctggggcttg tcagggagcc ctgagccagg 480
tacagggtgg agtta 495
<210> SEQ ID NO 204
<211> LENGTH: 545
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_18292 amplicon
<400> SEQUENCE: 204
ttctcctggg tctttccaaa cagccccatg acgaactgaa cccgtcttgc cccttccggc 60
tttcagttcc ccgcgcccag gcaggtcacg ggcagccgcc tgggcggggc ccgcggaaaa 120
ggaggtagtc ccaaccccca gagtagggag cggcggcact aggggatgtt gcgcatgcgc 180
catacgcctg cgcagaatcg agtgagtggg agactagtca aaaaggctga cgtcatcgca 240
catgttctgg tcatgtctgt gtgggggaga ccacggattc ggtgcttttc gtaaggtgta 300
gaaatgattg ctctgaaaga tacgaatttg ttggctacaa ctgcttctaa tacttcacct 360
aaacctagat gttgcaccag aagtctggat ctccacgcag acgtgtacac ttagcatcac 420
tttcccgaca gcttcatctt tgtgtccagt aggcaactca caggtgacaa accaaaaata 480
acctcttttt cctcccgcca acccactcct cccctctgct tgcaccacca tcacctggtc 540
actaa 545
<210> SEQ ID NO 205
<211> LENGTH: 597
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_12075 amplicon
<400> SEQUENCE: 205
gtttgccaaa tgacagctgt ttgcctccca ggcaggcttt gctgtcatca gagacaggga 60
tggagggaaa ataatgccat catctagggg aagggtcttg tgttgatctt caacatggct 120
aaccaaatgg acgatcagca ggcagacacg aggtattttc attttcactc ttatttcaag 180
agatttgtga tggtgtttca tagtctaaaa ataaaggatc cgcccgcaga catttctccc 240
tccactaccc tcatcatatt agctgctgcg ttttcctctc cagattttga ttctattatt 300
ttttattata aatgaaaggt caaggaatac ttttcgtatt ccataatagg attggttctg 360
gaagaatctt tgaaaaaaaa aatacgttca agacattggg gctgggaata gaacggaagc 420
atctcaaaag catgtttttc tggttaagga aagcacacga gaacgtttca cagcggtgct 480
ctgctatctt ctctgtaccc ctccgcccta cgctcatggg agagctcatt tctctcccca 540
tcagacactg ggaaatactc ccaaggctct ggcagtctca aggctgcaat tcctgag 597
<210> SEQ ID NO 206
<211> LENGTH: 477
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_22519 amplicon
<400> SEQUENCE: 206
ctcacgttaa tcaacccgag tccatcttgg tgggattgtc ttgctccgag gccctcccac 60
tgagctttat tttcctgcct gatttcgggg tccgctaaca ggatgaacag cggaccatac 120
aggcacggtg aaaatgacac ttggtgacgt ggaagaccca gcttgccaca gttgaggcag 180
agctcctcag ggtcttttgt cttagttatc cccgagctat ttttcaggaa ccgacaggct 240
cccccacccc aacaccggat gaaggccagc aactggaggc caggaataat caagcacgct 300
ctcatttcaa agaggtgacg attgtgcccg tgtttaaaag ggatgcctga gaccatgagg 360
atttggagtt ttggaggcgg atctgccttt ggggagtgag cgtagggccc taagatgtgg 420
ttgtgctttg agacagttcc cagggtgatg tgtcccatca tccaaacatt gcaggat 477
<210> SEQ ID NO 207
<211> LENGTH: 525
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_29531 amplicon
<400> SEQUENCE: 207
ctccagcact ttgggaatga aaggaattgc aggagagccc cggagcacac ggagttttca 60
aggagcttct gtattcaata aaaacagcta cttgtctact tgcacccgtc tgttagcctc 120
tcgctggtcg gcgggagagg ggaggaggcc agcgcctgat cggccacacc gctggagtcc 180
tgggctggca gcggtaacct tatccttgtg caaaaatctg cttcgtatgg cagacgtgga 240
accagtggac tcattgcgct gcctactctg aaaagtgttt ttatttttat ttttttaacc 300
caataattag aagaaaggaa tgaagataga atggagggac cctagaagtc aaaacctaga 360
gcatgtaggg aagtcctctt tggagatctg aaactgacag gtttatctct taaacgttta 420
aattcagcac taggttcatt cagtggcttt cctcttaaaa gagttgaact gtactctgag 480
ggagaaggag gaaaaaattt atgggagctg acattaagag ggtga 525
<210> SEQ ID NO 208
<211> LENGTH: 507
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_58853 amplicon
<400> SEQUENCE: 208
atgtcaggaa aggtgcagag accctccccc acacaccaca ttgttgttcc atccttctct 60
gtgcctttgg gcaaggactc tccgttctgt agggaccacc aggtggaatt aaagtctaca 120
ctcctccaag agctgatctt ggggcggccc cacctccatg cccctctaca gcgtgccatt 180
ctcatagaac acactaggac ctttgtcctc tggagctgtt cagtgcagca gctctgacct 240
catccttctc cagaagcctc caccttctct cccctctctc ctcctgcgct ttgtgtgtcc 300
tgttcttcca cttcggtgac ctgtctcctc ccctaatctg gctcagagag gggtaccagc 360
tgctgctgct gctattgctt cttcttctgt taaaggtttt ttattttttt ccaatgacaa 420
agctatgctc attctgaaaa catgaaaaat aaaaatgctc aaaaaataaa actcactcta 480
cattcattgc taggagagaa cagcctg 507
<210> SEQ ID NO 209
<211> LENGTH: 526
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_35052 amplicon
<400> SEQUENCE: 209
atcttcccag tagggctgaa tcctagacca atctatcaat cccagactaa tcaggcattt 60
gcctggggat atgcatcttt ggcatttttc caagggttca tcaggatgga gatatccggt 120
gcaccatgag ttctgtttcc ttaatcaaca ccgttgtaac ttgcccatcc agttttgtga 180
cattaattca aacctgtgcc ctagtcctct tttaggcagc gtatcagtgc tggaaagtgc 240
agcaaggata agagggtact gttctctcat ttctgagggc gttgtctcga taattaacta 300
acttgataga ctttttagtg agtggcaggt gagatgcaag gtactgtgct aggtgctgtg 360
ggggatgtac agacaaacaa cacacctccc taaggaggta agtaatagct acttactatt 420
cactttgctc tttcactgta atgtatcctc aagcacaggt tttcactaca ccatcaggcc 480
cagaagtact agcttatttt ccacaggagg atttcagttt gatgcc 526
<210> SEQ ID NO 210
<211> LENGTH: 451
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_67002 amplicon
<400> SEQUENCE: 210
cagtgctccg tgtccccaag tagttatccc tcccccggaa gactgaagtc cctggggcgg 60
gtaggagcgc acgctaggag tagtatgaat aaagtgtttt cttggaggtc atgggcaagt 120
ctctggacag ggttgatagt gctgatttat agagggcagt ctgggcacaa agagcattta 180
tacgatcgaa aagctgcttt ccctgccaac agccccatac cctccccagg agcgcgctta 240
cgccttaaaa gactcttttg ttatgtaaac tgacagttaa attaaacgaa ggtaatggat 300
actaaaggcg taacaggtat tgtaactatt ttactgttat cgatgctttt gaggttactt 360
acctcgcttg tattcgtatg gtgggaatac taggcgcata ccttctgagc ttcgaattca 420
gtaacctcac tgggaccttg aaatcggact g 451
<210> SEQ ID NO 211
<211> LENGTH: 571
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_45580 amplicon
<400> SEQUENCE: 211
gggtgcagga tgaagactag ctggctgtcc atagcaattc agtatgggag ggggacccag 60
gcacgaataa tcctaaacct gagcatgatt gcttacgttt gaaaaaggac atctaggccg 120
ggtgcagtga ctcacacctg tggtcccagc actttgggag gctgaggtgg gaggattgct 180
tgagcccacc cacaagttca agaccagcct gggcaacata gtgagacccc atctctaaaa 240
aaaaaaaaaa tctctttaaa ggcaatctaa ccatatgtga agggagctgc taaattcaga 300
ttgaggtggt agtatcaggg gcatcagaga aatcaccata attgtccaag ccagggtggc 360
agagttaggc tatgcagatg gcttccagag gacagcaccc agaggtaaca ttcatgaatg 420
cattcctgtt tgttggtgaa aagttcagcc tcaagactcc agggtcaggc ttcgtacatg 480
aaaagtgttt gccaagactc agctgtgtca ctgcagctgc ccgcccacag ctgagtcaga 540
aacgccgtcc tcattctcag tgactgccct g 571
<210> SEQ ID NO 212
<211> LENGTH: 550
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_12646 amplicon
<400> SEQUENCE: 212
gccttaggaa tttccatccc aacacgtctg tcctgtctgt cctctcggct aagcctctct 60
taattcttcc tgctctaaag accccgcaac ttgctatgcc ttcactgaga cttagctgct 120
ggcacttgct agcagaggac tagttagctc atgtgtgttg gctgttcctg gcccacccac 180
gctttttgag cttttaattc caaatcatcc aggagtatct ttgcgccgtg gattattttg 240
tcagtttatg ctactcgcgc catctttcgc cttttaagaa tcaggcaaac tgtgtgcttt 300
ctatcctaat agatggcaaa actcaaacta gaggccctat ttcacatcca ggttataact 360
gtggcaagag ggtggggtgg cttggctaaa aactagtcta cttttcttag ctcttgtctt 420
aatgaaaatc tggaagtctt actggtgatg gaggtagggg agggctgcct tcaagatcca 480
atctctaact tggaacagct gtggagagga gagaatacct gcttgtaggt gaggcatgaa 540
agaggagaaa 550
<210> SEQ ID NO 213
<211> LENGTH: 2400
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_00681 genomic DNA region
<400> SEQUENCE: 213
ggagctcagg ttgtttctgc acagaggtcc taactccaag agtggagcaa gaagagattc 60
caactgcact agaccctact tgcccttgga gaagtccaga gggactccca gcaggtctct 120
ggtgttttcc agcctacaga ggcctatcac ctccctaagt tgcaaagact atgaaaacct 180
ttttggtggg cagtggtgtg ggagcagtga attccagaca tgctccatcg ctcctaggct 240
gtgctggatg tcgtgggcag tagcttgggg accaggagcc aggccagagg accctcttcc 300
agaaggcact cctttacctg agctggagct gctggttttc tgctttgtgt tttgtcgaga 360
ctctttcatc caggggaaga tttgtttggc cactgtgggt gagttgagca gggggctctt 420
ggccgcgttg gcaggggtag ggttgttgct ggcattctga ggaggggagg cagaagaggg 480
aggcgggggc gcggcagggg taggtgcagg gggctgaggt gcgggctgag gcggctgtgg 540
ggcagggggc gcggcctggg gcggcggcgg gtgcaggggc ggctctccca ggcttggagg 600
ctggctaggt ggggcgctca gggtgcgcag gcacgcctca ctcagttcgt gtgccttggg 660
gtggcccccg gcgctggagg gagactggag ggagcaggcg ggtcggtggt actcgccgtc 720
ggcgcccaaa gcggcggacg ccgggtacgg ctgctgattg gcattataag cgaacccgtt 780
ggctgcctgg taggggtagc caccgtagat cgccgagctg tcgtagtagg tcgctttttg 840
catcgcgttg tttcacgatc ttgatcgcac actctgacag gggtttgaca cccgtgaggg 900
cgcacattgg cacgcccccg cggtcacgtg acactccgcc gccaatggcc gccccgcgca 960
gacctggtgg ggcgagaagc gcagcgcggt gagggctccg cgcaaatcca tcttactctc 1020
aatagctaag tgacatgaaa gccataaaag aaaaagtggt cagcaatatt tagcagcacg 1080
acttggcccc gggcgcaggg agccgtgcta taaaaaaccg ctggaattta ctggcagcta 1140
caaatatttg cttaacttgc gtctggagtt gggggatttt ccggggagaa ggagaatgag 1200
tgagggctgc aagctgattc tcaggagccg ggatccaaaa ggagaaaggc ttgataggct 1260
agaaaggaaa aaggctggga tctttctttt ccagggaaga agaaacttgg ggtgtcgctt 1320
agtttctgct ccttggcctc ctccagaggg cccaagactc ctccactctg ggaatgttgg 1380
gaagggaacg aggaggcaaa ggggagcttg ggtcgccaat gttttctccg ctttaggact 1440
gatgtttgcc aaaagagccc tgagatgggg taacttccca cccagctcct tcttggacct 1500
tcctgctccc aagagaggtt tgcacaaaaa atttcaggca atttgcccca tccaaccatg 1560
ctggatttca gaagctgagc ttgttaggaa gttaatccac cttgttgggg atatgactca 1620
cctcctccaa atgaacccct tgtggccaag ccaagggggg agggaaaact ttgtgtggaa 1680
cacattgcgt gtgtgtgtgt gtgtgtgtgt gtgtgtttag ggtgagggac caacagtaac 1740
accccaccca gcaagtcaca actaaaatcc tggagagttc tttactcctt tcctctccct 1800
gtttctcagg cacttcccag caagccaccc ccacttcttt acttctttcc cccagttaca 1860
gaaggttccc agaacctcct gtcttggact ttctaaggtg ctgttattcg gggcaactat 1920
caaattctac ctgttaaaac atgatggatt agagggggaa aaaaaacccc tccaggaacc 1980
tgaaaaacca gcgttcatct ccatgaccac agtttgaact ctccttccaa cttaacgata 2040
ataggttctg tcttagaaac tgctatgtaa tttgatgtat gggggtcatt tggctcccga 2100
cgagggatgg aagcacaagc cataaaatcc tgccagagtt tcctgatctt tgtgtgctgt 2160
tgttgttgtt gatattttgt tacttggcct atttacctgc ttcagaaata ccaagtaaag 2220
gataaccctg aaaatctaaa aagcagttga aaacctcctc aaccctcttt catttagaaa 2280
gcagtttgca aaagttaaat ctgttttctt tttgttttca accactgcat ggtcaacctc 2340
tagttctcag cacagaaaag ttccatgtga gtttcaaata ttcacccaca cacacactca 2400
<210> SEQ ID NO 214
<211> LENGTH: 4100
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_39189 genomic DNA region
<400> SEQUENCE: 214
tacaaagctg tatgaacagc agcagggtaa acagaattga tgcaattatc tgaaaaaatg 60
cagggcagaa aacaaatcac aatattgaaa gaaaaatgaa taatctctaa gaggattatc 120
caaattgatc atgtctttgg ttgaatttac cgctgaacgc tttctagatc caaaccctgc 180
ttttcttaat gtaacttaga tattcacaaa tcctacttga ggcaggaagt cagtcctcac 240
ttttaacgct taaagaccac aatggacttt tataagatat ctcgattttt aaagtggagt 300
ttctgggctg atataaaatt tattttaggg aaatacaaat atgggacatt tttgcatgaa 360
agagagaaag gagagacagg aagaaagaga cacaaagaga tagagacggt aagaaagaca 420
ctgacaaagt aaagggggag gagagagaga gacagagaca gagagaaaga ttgagagatc 480
aaaaacatca ctcaagaaag caagaggaga gaataattga gagaaacgca gagagacaga 540
ggcccagaga aactgaagaa agaggtagcg actcaggggg aaatagagat ggagactcag 600
agagaaggga gaaggcacag ggagaggata ggacccgcga gagaaagcct gagcgcgcgc 660
tgagacccac ccagcatttt cacggtttgc ttgtggttct ggtccctgag cgaggcaccc 720
acgacagcat cgccgcgcct cctccgccac agcttcctgc cgatgagact gtagaggacc 780
gtgagacaga agacaggaag gaagaagaag atgctggaca cccacaccat gaccgtgagc 840
agtccagagc gcaccgcaaa ctcggtgggg cggcactcgt tggtgtccca agggtcggtg 900
ccgttctcgt gctccacccc gactagcacg aagatgggcc cggcgctgca gaaggccacg 960
gcccagatga cgaagatgac cagcttcacc cgccccttgg tgaccaccac cttggcccgg 1020
agtgggaagc agatggcgaa gtagcgctcg acgctcagcg ctgtgatggt gagcaccgtg 1080
gcgtaggtgc agctctcact gacgaattgg aagagtttgc agaggaggtc gccgaagttc 1140
cagggccggt actgccagag gcgaacgagg tccaggggca tgcagaggaa gatgagcaga 1200
tcggagaagg ccatgctgga caggtagagg ttggtggtgg tgcgcagctc gcggaagcgc 1260
gacaccacca gcatggtgag caggttgcca gcgatgccca ccacgaagag tgccacgcag 1320
gtggctgtga cgcccgccag cagcggcgcg gggaagagct gcagcagctc gtcgcccagc 1380
gagtcgttgc cgggggaagc atcccagtcc aggtcggcca gtgtgaggtt gaaccccggc 1440
tcttcgctgg gcgtcgcgtt ccacatgctg ccggctcagc tgaacaggct ctgggacgtg 1500
actgcgctgg gaggctggac cgagctggct cccgaggagg tccgcttagg cgcgggaggg 1560
tgcgagggag gagcgggtgc agacgcgtag ggaggatgct tggagaagaa agagagggag 1620
gtgagaggca gaagccgagg aagaaggtga gatggggaca aggaagaggg agagagactg 1680
gtggtcagtg ggtgagagag tgacccactg ctttctctga cacctcccct ttcccccacc 1740
aactccccca aagtttctcc caacacatcc tccggccggc gcccacacgc atacctgtca 1800
ccagccctgc ctcgcatttg cgttctcgat ccagttccat ctcgcacttc ccaaagcgtc 1860
gcagcgagtg gggaccgcag ggaccaggcg ccgcgaagcg ggagcgtgag gcgctctctc 1920
cgaagccctg ggcgacgctg gactagtgtg ccccggaagg acaggtcaca cccgggggtg 1980
ggggtgaaga cgacggtggc ggtggggagg acacctttag cagctgggac ctgatttctt 2040
cctccacaag gctgcagctg gctatggccc tggtggaaag aaaaagcgag cttgaccaac 2100
tcgacttggg aagggggata gagagagaaa agaaggacct tgtgtttgta ttcataccgg 2160
tgagcaccaa agaatagtct cacgcagtta taggacccag gttcagcgat gtgactactt 2220
gtccaaggtc acacagcgag ctggggactc ggggaccagt gtcggatctc ccacccggtt 2280
gggacttctg agcgcacagg ggcaagatat gtgagtaaac cctgtccaga atcccagtcc 2340
tttgtatcac tcggtagtgg tagagagtct gctgtagggt atattacttt tgcttgatgc 2400
aaacctggtg gcggggtgcc gaggttggtc agggagggaa caggagaaag gaaaaaggca 2460
gggttggagg tgtgtggagg cggcaagtga agaagaggct gtgaggctgg cgcgtcgaga 2520
gtgtgcagga aacatttttt gaggcataac tgagagagat cagccattta gtagccgtat 2580
tcccttgggc aaggtcttca acctcctgag cattacgtct ttttctttga attgcaatga 2640
tttgtgcgga ccactggggg tgatatcaag tgtcagggac caccggaggc actcaataaa 2700
tagaagacgc gttgctgttg agaagtagaa gctgtgccgg tgggaacagg tcaaaggcca 2760
cccctacact agcaaggtga ccctctggac gcggtctgtg cgtctcctgc tcagagccag 2820
aaatcagcac ccgaaggcat gagactgcca gttgccagcg aattcacaaa tccgaccggc 2880
ccctcccggc ccaccgacct cgggaccgcc ccaggaacat attcagcact gtggccagcg 2940
ccacatccat cctaccgcaa agcgccgctg gaggaatggc ttccctgtca ctcccaccgt 3000
ttttaacttg cgcttctaac gcctcagtcc taccccacgg aggagcaggg cagactccca 3060
cgaagcacag gccggcgtta gtcactgcct tgaccataca catcggcgct cacccgatga 3120
gataccacgt actgtgtatg agagagtatc cccctcagtt gaatgcgttt gtacttgcct 3180
ttcacagaca gtttgtacca cctctactac ctaaattgtt aatacttaaa agtccacaaa 3240
gacctaagac tgaatgtgtg cacaaatgcg tgaaagactc catgcagtaa attactacat 3300
gagagaagtt tgatacagga aatttaacat agtggtttgg ttgccgctgg tgtgttagac 3360
attggaccaa actgagtttt gtttcgtttt gctttgtttt gttttgtttt gctggttttg 3420
ttttgttttg ttttgagacg gagtctccct ctgtcgccca ggctggagtg cagtggcgcg 3480
atctctgctc actgcaacct ccgcctccca gtattggatc tcccacccgt ttggacttct 3540
gagcgcataa gtccaggttc aagcaactct tctgcctcag tctctctagt agctgggact 3600
acaggcgtgt gccaccacgc ctggataatt tttttttgta tttttagaag agacagggtt 3660
tcaccatact ggccagtctt gtctcgaact cctgacctcg tgatctgccc gcctcggtct 3720
cccaaagtgc tgggattaca gccgtgagcc actgtgcccg gccccaaatt gagtttttaa 3780
aacattaatt tcagactact attttttaag tattacaact aagtcaaact accaattaca 3840
aacaagtttt tatttaatca ataactttgt tactccctga cctatattat cagtaggttg 3900
atgtatgtgg aaagaaaggg agagaaagtg gactgggata aatcagaata ctatgggaag 3960
ttattgccta agactgagaa tcaggaaaat attgttggat atatttctag tctactcagt 4020
gctaaagcta tggctgatag ttgaaaaaac tgaaaacaaa aaccaccaaa actattgtga 4080
taaaaaaaat tttcatgtta 4100
<210> SEQ ID NO 215
<211> LENGTH: 5000
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_00644 genomic DNA region
<400> SEQUENCE: 215
tagatacata cgggattcag actagatttt tggaaggccc tctaccccag aagcacagcc 60
ttagaactca tcagttttaa gatgtattcc tgagctctgg gggacacaga agttgctact 120
attctaggca tttccctgaa atgttcaact ttccattgac caagaaagca gctcgcccaa 180
gtgtgtggga agcacttggg tgggacactt ttctgcccca tttccagaag gattatcttg 240
gtctgaggcc ttctagtgac agctttagag aagctgactt tagtattcgg agagaaccag 300
gattgctcca actttctcag cggtattttt tcggaaagcc attaaattcg tggctcctct 360
gtgcgaagtt gatttctatt tggctttgaa ttgttgacgg ctatttcttc cttaatgaaa 420
gtgttgtctg ggtgaaaaat atatcaggtg gctgggaaat tggttgattt ttttttgaga 480
taggtgccca gtgtcctatt tttctatctg aggaaagatt ttctgcagac tacagaaatt 540
gacagcattg tccgggtaat aaccgtcgtc gacaatattt tcgaaagggc atttgagtgc 600
cgaaagcatt tggatattgc tttttccaat aagaaatttt ctgccctgag cttctttgat 660
tttatagggg gtggggagtt gactaggggg gcgatgggga agaaggagcc tcgcattggc 720
aaagagatgc cttccccatc ctcccagtcc tggaatacca aggtgcttgt cagcttcacc 780
tggaattcct ggatctgaag agccctcaaa taattcggct gcgagtcaaa agggaatttc 840
aggaatgagg aataacactc ttcttgcgct cctgtaaagc aagtgatgga agctctgaaa 900
gtttgcctgc tctcaagtgg gaagttagga agtgtgcgtt ctttctgatt tttttaaaaa 960
taaaaagtgt ctagctttga ttcgattcag gaaagctcct cttgggcaac cattgtccgt 1020
taggggcttc agatctcatt ttaagacctt aacagtcctc gccgttctaa ttaaggaaag 1080
gcaggcgagc ctgccagccg agagcggttg ggtcagcggc ttcatggtgc agccgagtct 1140
caaagcgggt ctgcactctc gcctccctct gcattctctt agccactatt tgcctggtcc 1200
cgtcgcgtgt gtgcaggaag tttcagtctt gatttatcca ctagtcaagt tcccgaccag 1260
ctctttttct ggatgtcagc actaaccccc tcccggagct tggtaaacac agcgcgcgca 1320
tttttctgcc tcagattggc atgttgacga ctctgcttga aggaatgtga caataaagtg 1380
ggaaaccaaa gcttggcaag cacttaatca aggataaaaa ggttccgttg taaggatgtc 1440
actcaattta ttgtgaaagt cgaatgaatt acgtttaatg aaagtgctcc ccagatgaat 1500
attaccagca atttcctgag ttggctctgt cagctcgaga tgaggaaatg ccaacccaga 1560
tcagaaaaga gcgcccgtct caattactat gcaagctttc caagagcggc tttttattga 1620
gataatatat tttggcggct tcttcaaacc cctccgcgcg cccaagagcg cgtttgcgca 1680
ttttccaagt ttgccctgcc ctcgcgggtt ggtggctgtt gtttaaactt ctgatgagcg 1740
cgctgcgttt ctgctacggg atgaaaacct aattacctcc tctgcaaaga gctttcccta 1800
gtatatttta ttgattgcgg aggtgggagc cggcaggggg tctgtggggg tgggcgggga 1860
ggggattctc ttgctccggt gccctctgtt gccgaaagtt ccttaggcgt ctagtcaggg 1920
gttcggggtg gtggaaagcg agatggcgtt gggagccagg gcgttgggac ggcacaagca 1980
gtggggtccc aggagcagca agacagtagc tcctctcggg ccacggctta cgaaaagctt 2040
tcctagctcc ttcttcctat aaattaatga gggtatttta ctcgttcaag ccggaaatac 2100
gatggggagg gggagacaca ggccgcatcc agagcgcatc gcctcatctg catgagaatg 2160
gagaaccggg aggcttttct tgtactgttt ctttctccca caataagaca aattgctgct 2220
tagaaaaact gagtgtttcc ttagaaactg gcttgcggga gctctgcgcg tccccgctga 2280
acctgcctct ggccgcgcct cgccatcacc cccgccgccc taatggattc tgaagcgaag 2340
gatcctagct gccgcggcta agggcgcagg gggaggccgc gcgtcctcgc cacaccggaa 2400
ggagagggca tccggctcac acatcccacc ctatgtctta gaccccgtcc tcacacattg 2460
actttaaaag gccattttcc ttcgtcttct acaagaagca agaaactttt ttcgacgtag 2520
gcttcatacc ctcccttcgg aaactcagtc cgctgaccaa agccgcagtg ttcaggcccc 2580
ggggtttccc agccgtagtg gccgccgcca cagctgcgcg ctttattgtc tgctttcagt 2640
cgcaggtgac ctcgagcgat ctcgacaggt ttatggaaac acagatgcag ccctctcgcg 2700
tccggagccc aagtccccat gcaaaagcgc tgtttctggg taattttcgt cgacgccacc 2760
aagcttcggt gcttttggga cagcgggctg gatagcggca gttctcggga gaataggccg 2820
cgggctataa gatttgatcg cgggcaggcg ggcgtggggc acgccagggc cgggagagcg 2880
actcttcagc accacggcca gcgccacagg ctccgccccg cctggtgcca gcagtagggc 2940
ctgcctcccc cgctgccgct ccggctgggt ccttaaagtc gagttagcac tctcggtttc 3000
cgcagatacc tcctcaaggc ccgctcgcga ctgtgacgac ccgcctaccc cttccagcta 3060
ttcggggggc agctagctcc cgtctctagg tccccagcat gacctgcggt cagaaactct 3120
tgcttgcacc cctctccatt accacactca gtggttgcgg cgtcacgtga tcaccacgga 3180
gattttgcga atccttcttt tccccaactt ctccccctac ccagtctccc attctttcac 3240
agttcattaa atctacccct cccccgaaac agaaacgtga aggctgtaac gaagagctag 3300
aagtgtctct agtaatgtaa aagtctcaac tgacagacaa ggaaactgag gcaaccaact 3360
tattcgcaag agtaaaaccc tatggggaga agcgattcct gcccctcttc ccccggcgag 3420
gaacacggct ggagccaccc aggcgccttc caggctaagg cgcctttagc ggcgcgcagg 3480
ggtgagggag agggtgggga gagtcctaat tattatgaat ttctaaaggc gcagtaatta 3540
ttcacgggga gcaggacaaa ccatggctag gcagggaaat cgatatattt gctatcgaaa 3600
gttcctggct cgcctttaat gcagacgaat gggggatgca gcctcattat tttccgtggt 3660
taggctcgcc agcgtggggc ctgatgcagc gtgaaatcta tcatcattag acccgggatg 3720
gagcggcggg ggggagtttc tctttactta ccaaaccgca acaacaaaca aacaacgacg 3780
aacaaccgcc ccctacaaac actcattctc acacaacgtt gccctacctc cctcgccgct 3840
tgccctggcc gctgttgcac actcccctgg gggctgtctg cacgccctag agcagacact 3900
gcggtcactt aaagtgcgcc cagttcctcc accgcagcgg tcacaccgtt gatttgatcc 3960
agaaataaga cggatagtac cgagcgttgg cgctaggggt tgtctatgtc aaaggcgaag 4020
gttggctggg aagttctgtc cgtttctctt gccttagcat aggagtcaat ccttttcttg 4080
tcacccgatt ctgcaaattc tcgctgtatt aaaggagcag agatctggca tgtagtgctc 4140
cattaacccg tagcataagt tagctcggac ataaggcaag ccctcgagaa gggaacgaat 4200
cagaaggtga aaagagcggt cggaaggtga ggaagagaag gtttaggcgc aacgcctcgg 4260
aggtattctc tgaggccctg gcgagatttc ggcctttagc ttaagggcca gcccgctagt 4320
tttctaggac tgggtatagg ccccgcctcc acccaccgag gtcactgaac tgcccagggt 4380
cttgcctgct ggattacaag cctattccca tttctcctct cttccgcagt ccaccctccc 4440
tggcacagtc tttttcacac tcagaagttg cctgatgccc ccgatggaca gctgctggga 4500
tgaaacttgt attcctgtac aggtgtcttc gcagttacct gcaataccat agtacttagg 4560
gttaactgag gtgtgtgtgt gtggtgtgca tttgtcagtg cctcgtcttc atcgtcttca 4620
tctagctcgc ccctccctta taacagtgaa tcaatcgctg caaagaagat aggatgtagc 4680
agttttaaaa taacctaact cctccttcat tgcagtaaaa tgatcgcatt tataataaca 4740
ttaatgagaa caaaattaaa aattatggcc ttccaggcat taaagtaata ctatctgtcc 4800
tcttctcttg gattttcttt tcctcagagc ccagcctttt tatggcatat tgtgattacc 4860
tgagtgtctt tgtttccttg tggtcagaga cagctagcca acacaatact aggactgtat 4920
gatgtagggc atgatttcct cccaccctct tcatttttag aggctttgta attaaactct 4980
gtgagatata cgtaacttac 5000
<210> SEQ ID NO 216
<211> LENGTH: 3400
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_81674 genomic DNA region
<400> SEQUENCE: 216
ctggtgtcag gagcacagaa gaaagaacag ctggtaagga gtagagaagg agaaagaaaa 60
ctactttttg aaggttagga gaaatactgt ccattgattt acttcagcaa ctgcctgaca 120
cataatagat attcactaat actttctttg cacctcatag cttaaatgtc ttgaagaaac 180
aaaaattgaa tgcacaggat caaggcacta aagcttagat aacacactcc tgcatcgttt 240
ccctgtttta tcaagatatc tttcatcttt atatccggca atttagtggc aactcttcgc 300
tttccaactg cgcactgagt ctttcggtct cctccccatt ttcctagtcg tcttcggttg 360
tggatgttgt aaactcgacc atccgtctct caaggtcttt ggcttcaagg tttcccaatg 420
ctctggagct gtccaagccc cggtactccg gggtggaaga cctcagattc atttgacggg 480
cttgtggagg ttgggggtct gcggagcccc gtgtgggtgg ggctgggcgc ggccggggcg 540
gagccggcga ggagccctag ggaaagggtg aaaggcacag ttgagaaagg cccgccgggc 600
attggtttca cagtttccac gaaggcttcg tgtgcaagcc tgaggagttt aggtgcctcc 660
ctcctgcctc gcctttcttg gttctagaac cttcagtagg cttttctggg ttgcagggac 720
ccggaaaagc agcggcttcc actcgggggg cgggtcccaa gggtcttgct gctgctctgg 780
ggccgtttgg actcctggtg ttgggggagg ggtcagggag gtgctgctcg cgtctccttt 840
tgcgcctgcg cggcgggctc cgagcgggta ggagcgcgtg cgcggtgacg tggacgtccg 900
gtgcgcgcgc gcaggctctt cagctggagc ggacacacgg tgtgcgaacc gaacagaata 960
acccgccccc agcgggatgt gaaggactcc gggtgaggcc ggccacgccc cgcacggtaa 1020
ctctcgggcc tgggtggagg gcatcgctta gtactggccc gattggagtt tttcgagagt 1080
ttgaagctct tgtgtatttg aacggcgtga gaaacgttcc gctgagagag cttcgcacgc 1140
cctcgccagg ccgggccttg cgcagggccg cctttggcgc gcccctgtgg tccctgagcg 1200
aggctgcgca tgtcacctcg cgcgcgtccc cggcctcact tccgcgtcgc tcagctacct 1260
aactgggaac atcgacgcca gagagagcgg ccacgaggcg ggaggggtga gaagcgccca 1320
tggctcggcc ctgccctcgc gtgtgtgggg tgccgctccg cgtggtacgg tccgcgtgac 1380
gacttctcgc ccggcgccgg gctctaggtc gagagccacg cttacgcgct tttcagttta 1440
gagcctaggt ctcgtggttc tagaactcca agggaaacgg tgtcggcgtc gcttttctga 1500
gaacttggcg cagcgttttg acacctgtgc aaacgtcttt tctaacaagt aatttccggc 1560
caaattgttt gaggcaggac gtcaagttta ataaaggagg gcgaggaagt gagctgtagg 1620
agtggggact tggtaaacaa aggaccggtg gtgtgtaagt gcagaaatga gggaggggaa 1680
aacaggtggg aagagcaggt gttattttct ttattcctct gtggggcagc cttttaccta 1740
gttctgttta tggggtttcc cgtttctgtt aaatggtcaa gtaggtctct gccctcagtg 1800
caaggtatct gggacattaa catcaccccc ccaccgcccc cccaaagctc cagtagccaa 1860
agttgaggga tctatgtgtc agaagaatat ggggaaacta gggatcgttt cagactgggt 1920
cgggagtgca aaagtggtag tgtcttgctg tacagatttt tgccttgcct ttcgaaccct 1980
gggaatgcct tctttctctg gccggggtgg aagcaggaac gggtaaatga ggtctgaaag 2040
gaggggttac tgatggcaga ccaacacgag aaaccaaagt gcactctttt attgggaaga 2100
taactttccc aaggttcgcc tcgccggagc aaacacgtgg atcatgagaa gtctcgagcc 2160
cacccgcgcg tgttgttgta gagcttgcca ggcttatgcg gctgagtccc tggttaacaa 2220
ctgcttgctc tgttcgttct ttttgggcac gatgccgcgg ctaggctgca gggaaagtgc 2280
ctgggggcgg cgtgacggct gctgggaagg gggttggcag gggagggtct ggtggctggt 2340
tctgtagtct ccaaggtaac agaacgcggc tgggtcccgc agagcgatca tcgggttccg 2400
gccggcggca cgtgatctgt cgggactctt ccccggaaga gctttccttg cggcattttt 2460
tcacgtggtt cttggccagc tgtcctttgc agttgaaaag cggcggtttg tgggtcatta 2520
atagtcgacg gcgtctgctc ctctcgggga aggcagtgag accgagcctt ttactttcct 2580
gcgtatcgga acagcgctag tgtttcttgc cgccaacggt tgtttctagc gtttgtgtgg 2640
gttaagtggg ttgggtccac tttacagaaa acacaggcta aagacttgag gaaattcagt 2700
gccctgggta ccttggcata cttacttcaa gtttgactac tgccagtttc tgccttaaaa 2760
gttcttcaaa ttctgcttac ccaactgcta gagacctgtc agctttctgg ccctgagttg 2820
tagttagggt ccattcttag gaataaaaaa tactcctgcg gctagcagta acaaatgata 2880
tctgggaaga gaaggaggca gtactctctt acgcaggtgc aattctgtgc cttaaaacct 2940
aaaagtgttt cagataatat tttgacattt gccctataag gttgtgacga taaaatgccc 3000
aggatattgt ctgttccgaa gtgagtagtt cttaataaat ggcaagtacc atttattaaa 3060
ttagtaaaaa taagcaaatg atggttaaga gcgattaaga aagtattaat agttggctat 3120
tttactgtct ttgccaccat ttgctttcat tttattatat ttatatccac attctgtttt 3180
taagaaactt aaaatttctt gacccagtgt ttattggcta aatactgaaa tctgagtgaa 3240
cctgttctct tgaaatttga gtttcacaaa tgtaatttaa ccatattctt atagtgaagg 3300
atcatattaa ggaatatact aacatcttgg tgcctgccat actactgtat ttattgtatg 3360
aaaggttgta gaagtttgta gcaatttgga aaacgttcag 3400
<210> SEQ ID NO 217
<211> LENGTH: 2100
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_81149 genomic DNA region
<400> SEQUENCE: 217
ggcaaatagg tcaatgctgg gaacagatgc ctgcctggct gagtgctggg aaagaaaggc 60
agttggaggg atgtgtgggt gcctgggagg gcgtgggtgg tgcccaggag gctatgggaa 120
tcagaatcac acttgcacaa gagaagaccc ttatgggaca agtaaaatca gcatagtttc 180
ttgggcgggg caaaggtgtc ctgatgagga tgctaggggt caaatatgtg tctgggttct 240
gccccaatcg ggaatgagac acagtactga agtggaacgg gggtagcatc tccacccacc 300
ttcacagcct ctggggaaaa gaaagctttc cttgcagccc aactccaggg gcctaaatat 360
tgagcaccaa cacaagacag gtccttgagc ttctcggagc gagtcgggga agcagataat 420
ttcagatgca aagtgccttg aataaacaga acgaaagata gagagccaga gggggagaaa 480
cggcttggtg tggtcagggc aggcatccat gagacctaaa cgaagagggg gcattccaga 540
caaaaggaac agtgatcaca gaggccccga gtcaggaacc agctaagggt cttagagaag 600
agctgcctcg taaagctaag caacaataac cagggaacgg tgggcatggg ccctgataga 660
caaggcaggt cttggctttt taagccatag aattggattt taggagggat gggcccgccg 720
acaaagccaa caaagtttta acccgaagat cgctatctta tttatgcttt aaaaagacct 780
ctctggcctt tctgcgaagc tctatcctta gctttctctt gttagcattt tgattaacga 840
atgtgggcac gaacagccag ctgaccgacc gcgcgcgcag tcgagcgtcg gttcctcgcc 900
ttgggaggga ccactggagg ccccgccccc tggccgcgag cgcacctcgg ccccgctccc 960
gaggccctac gggcgtggcc tctgtcccgg gtcccgcccc ccagcactcc ggaacagcgc 1020
gctcgcagcg ggaggtcgcg aagcctggga ctgtgtctgt cgcccatggc cgccgcgctg 1080
ctcgcccggg cctcgggccc tgcccgcaga ggtgagtgcg ctggggatcc gtacggcggg 1140
gcttcagccc gcgtctggcc cagcgggcgg aggtcctggc ggccggctct gtcagagccg 1200
ctggcaggcg gagccccact ccgggagcgc tcacggcctt tgccccagtt ctgctgctcc 1260
ttgcgccgac ccagcccggc ccttcaggcg tccctggttc ctgcacagac ccctaccccc 1320
cgattgaccc cagccaccag cccagttccc agttcccata tctccctccc ttcatttcac 1380
ccccactaga ggttcagggt gcgtccttct tccggagcca ggcctgggat tgaaccagac 1440
ccgcatctgt gaccttgggc aagacagccc ctcctcagcc tcggttggcc catgtgtaaa 1500
atgtccacag agaaaatcag agttgttggg aggattaaat catagggtat gtaaagcact 1560
tcgtgcctgg cgtgtaacag gtgttccaca aatgctcgtt cttgctggtt aatacagtac 1620
ctttcccatc ttacgtgtct ccagttgtag cagccgtgac acatatagcc acggcttcct 1680
ttgcctggcc tgaattacaa ggggaacgct actgagaact gtgttaagcg ctagttagtc 1740
tttctttcgc actccgagga gcggaatact attcgcctcc acttgttata gaaacggagg 1800
ctcactgacg tttaaaaccc ttgcctaagg tcacagagct gaggtcttat tactgttggt 1860
attatactga ggactgaagg atgtagtgta tggaaatgtc tagtgagtgt actaagcatt 1920
cagttagtat ggggttttca gtggccgcca tggacatttt gggctgacag ttctttgttg 1980
tgggggctgt cctctgcctt gttggatgtt cagcagggat cccggacccc tatccactgg 2040
gtaccaatag tattcccctg ctctagttgt gacaactaga actggctcca gacattgcca 2100
<210> SEQ ID NO 218
<211> LENGTH: 3200
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_83841 genomic DNA region
<400> SEQUENCE: 218
ccatgtcact ctttcaaatc taatcatttc caggcacaga aataaatcca aatttccttc 60
cttcaaggcc tgtagttact cctgcaacag catctcgcag tcttccttgt tcagtaggcc 120
ctcgccagtc atactgacct tgccaagcct ggagttcacc aagcacactt ctctctggtc 180
agcatttctg ttccctccct ttagaaggca ctttacccat acagtcacat cgtttcttcc 240
ctcactgtat tcaaatctct gctcaggtgt tacctcctca aagagaactt ccaaaactgc 300
tgcttgaaat aattccccgc cccatcacac cctaacccct aacagtagtg ttatcactac 360
cagataaata ctttctactt gtctgacccc tcctctagta caattaaaac tccatgagtg 420
cagggttttc acagctattt ctccagcccc tggactcggg gttcttactc tctggagccc 480
agtttgagtg acctggagtc acgagggagg cgagagagaa gggttaccag cgatactcac 540
acaacatcct ccccctctgg tgctttgccg ggtccctggg aactgctaca ggggctgcac 600
agcggctgac cctggccttg tcaagcactt gacacataag tgctccaaag tgtctatgga 660
atgaaatctt caataaaact ccaaacagaa tgctgtagtc actgacactg cttcctaaaa 720
cgtggccaac aattccgtat gtgacaaaca ggtcacattc ttgatttttt ttaacgacca 780
acaaagttaa aaccctctca tctttccttc ctgagctcca tgcaaattac ctattcaaaa 840
gcaactaagt atctccagtt ggatattctt aggcatcatc tcatccttgc cagtctctgc 900
aaaatatggt cgacaaaaat aaataccacc ttcttaaata ccacccagct gtccaagatg 960
gagacttcct ggcatccagg cgccttcctc tccctcgtcc ccacctctga gaagttccca 1020
agcacgaagt gttctgcgtc ccgaacattc caggggccgc cagccaccat gggctctgtc 1080
ctgaggtgcc aagcaggaca tccctgcccg acatccttgt cctcccgcac cgcacacgcg 1140
ttagtggctg tggcgtcgcc accccagcac acgctggccc gcccgcagtg ccaggctgga 1200
agtgtcgggc gcttgccagg ccaaggggca attctgttgc cttccaggcc ttttcggcgc 1260
ggtcccagtc aggaacgcgc cctgtcgcct cccactccgt cttccggacc ctcccgatcc 1320
tctctcgtca gcgatcgggc gtcgctcccc tggactaacc tcccttgccc catcttcagc 1380
ttttcgctga tctgcatctt cctgcgcctt agtgcaaggc agagacctgg ttctaaagcg 1440
aacggaacgg aaccgattct gtaagttgca atgagcgcgc tgaggtcggc gtggaggggt 1500
ctctgggaaa ggtagtttcc gcgcctaaag cgccggggcc gggccctgtt cccgcaggcg 1560
caaggcagca ctgtctccgc cgattgtccc tctgggaagt ggagtctggc cggcggaact 1620
gcagcagccc tgagacttgt gggaattcgg cccaagggtt cccagggcaa cgcgcaagcg 1680
cagttcggct cccggctgca gactccagct cattgtgttc tgactgcgat gtggcgcttg 1740
cgatctctcg ccgccggcag aggctcctcg aagagcgaca cggggctgac caggcacggt 1800
ggtcaaagcc gcagagggag agcgggagcg gtcgtgaggt cgtctgggga gaagggcgga 1860
ggcaaagccg aggaggtgcg ggttgtggtc cattctggag gacgctgatc gaatgcccca 1920
aacttcccgg aatgtatgtc tgagatttga tcccagagag ggaggacggc caggggtggt 1980
catcctgggc tgagggtcga gtctgtgagt gcctgtggag gagatggagc cagggcctct 2040
ggcatgtgtc ttggagcgga ctccgagaag cccagggttt cctctcaggt gatagataca 2100
cgcctggcgt ggttccgagt cctgcgccag gaactcgcca aggccggagg cagccgctgc 2160
gcagcccctg ccacagcccc cgagggacct ggcgaagcgg caggggcggg acggggctgt 2220
gtgtgattag ggttcctaac ccttccctct cccctcccgc ccagctcaca caaacgccgc 2280
ttctgcccac ccgtgactcc aggccaccca gactgggccc cagagagtga gaacactgag 2340
gccagagaag ggtttgcctg agaggcttcg acagtgaaga gccttcttag cctcctttct 2400
gaggaggaag aagaccaccc tccttttcct cttctcctgt cactgccaga taaggcagct 2460
gttccaaagc cgcagaggga gagcggagcg gtcttccaat ccagtcgaac ccagacactg 2520
ccctccgttg cctctcccca gcgctcccac cttttcgggt acatcctggt gggttctgga 2580
gctgaataac ttgttaaaga gataattctc ggccgagtgc ggcggctcac gcctgtaatc 2640
ccagtacttt gggaggccga ggcgagccga tcacctgagg tccggagttc gagaccagtc 2700
cgaccaacat ggtgaaatcc cggtctctac taaaaatata aaaaattagc cgggcgtggt 2760
ggcgggtgcg tgtaatccca gctactccgg agactggggc gggagaatcg cttgaacccg 2820
gaaggcggag gttgcagtga gccaagatcg tgccactgca ctccagccta ggtgacagag 2880
cgagactctg tctcaaacaa acaaacaaaa aaagaattct cttgagatcg ctcagtgagg 2940
ctgaagggaa agaccagagg gtgggtggaa ggcatgagaa ctggacctgg agcaggcttt 3000
ctgcagggaa aagtcaatgt atagtaccct cagaaggagg agagagaatg gggagcaaac 3060
aggaaccaaa acactcactg cttggggtac tggaggcctc ccaggatgtg aatgctcact 3120
gcctcgctct ggactgctgt atgagagctt ttgacccagt tctctcctaa tagcaggtgt 3180
gtggaccctt ctagcctgag 3200
<210> SEQ ID NO 219
<211> LENGTH: 5900
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_38705 genomic DNA region
<400> SEQUENCE: 219
agaagaccaa gtaaattcca aggcacaaag gcaatgaaga ctaggattga gggtggggtg 60
cagagaaagc agtgtaaaac ccatggcctg aaatgcagga tttgtggagg aaagattggg 120
agctgagact ggacatgtgg atgtgagtga gtgcactgta aatagtctta aatgccaaat 180
ggagttagcg atcgaggaga aagactggag aagaagccca gtgtaatatt tcttagacat 240
cagtcctaag gagagagggg gagaaaagtg aagcgggata gatttagggt agagatgttc 300
aggagaggcg ggcgacccat ctcagatgaa attcagaaaa actgacaact gactaggggt 360
ggcaggatgg cacagcccac tccaaaatct ggtagactct ggtagactct tcaagatttc 420
ctggaagact cctaggcgga gaactagcaa catcttgatg ccactgctgc agaagtggta 480
aggggaagtc ttgggaggag ataacttcca gaaggaagac aaaggggcag gggttttgga 540
gctagattaa tggctgaaga tacgaagaac cagaacgcat atctttaaga tgtatgaggg 600
cccttttccc caaaagaggc agactgcgaa ttaaacgcaa tataaatgag gttatcacag 660
tccaggtagt cgtttctgaa gccctagtcc tcagttccca aagaaaccac gtgcgcacta 720
ccacctaaaa ctgccaatga aaatgaaggt cctgcgcagt aaaatattta tacaactgct 780
ggggccacta ggcttcagcg ggtgtggagg cggggagaga ggaggagtaa aggctgttta 840
caaacttgac gtacacacgc agtcctatcc ctacggtcct ggaattgggg gttactatct 900
tggaatctag gggcactcca ggctctgggc tcagacggct ggcttctgcc tacccgagcc 960
ttaacctttc aaggaccaga aggattccag agctcttgcc ctaggtcctg gggcagcgat 1020
gactcactgc agcaccccct cccacttcgc caagctgccg tctccgccca cccccaaaca 1080
atctcgacag cgcatttcgg gagccacggc tccgggcgct ttgctggggg ctaaaggggt 1140
ttatcccttt ccttgaatcc cagcaggcta gaactacccc ctcccagtct tcaggcttgc 1200
cacgctctcc acccgatcct tccattgaaa ggcagagaag gaaggatgtg cttgggaact 1260
ttaagaccca cgaacgacag cgcactgatg gagcagccca gtgtctgggg gtgagtatcc 1320
aaggccccgc ttagaaaagg gagggagggg ctgtgggtgc ttcgggaaga ataaaggcat 1380
caccgggcac agtgcctacg accccattgc gcttacagcg ccgtgcgctg ggagagactg 1440
acccgggaaa gtttctgcgt cacacgcgcg tggcagaaac gcacgtcgct tgggaaagtc 1500
aaggaccacc cttgctcggg ccagaaccgt accgcagcga ctcctcaaat gtcgtggaga 1560
agtggggggc agatgccttg taagatccac tggagggcac atgcgggggt cgacagagag 1620
tcggggaacc aacgtggatt ccctgctaaa tgctatttgg cagcgcaaga aggcggcctc 1680
cccgccctgc ctcagtccct agggaaacgt gcgccgcagg ctccctctct ccactccctg 1740
gaacccgtga gtagtagaaa ccccagagga accgaaatca cgtccggaca gcctctccag 1800
gctgtctccc actatcccgt ttctcccggc caccccgcca gtagggtgca gagttggact 1860
gcgctgcacc cccactctcg gttccacccc aattcaaagc gtccggggta ggctccgcct 1920
tctcccccgc ccccagagcc ctcggcccac ccttccgttc ctgggacggg acctgctccc 1980
tgtcaatcca gttcagcctc agggttcctg gcgcgtgaat aaaggccctg agagaaagcg 2040
gggactctag attacgcacc gccctccaca acacacactg aaggaactcc cagtgccttg 2100
ggcaggggat cctcagcccc acatccccga tgcaaggcgc accaataagg agtctggtcc 2160
gccctgcgct cagcggctcc gctcccgggt ggccaagttt gctgcaggga accgcaactc 2220
cagtaacttt ctccgagttt ggaaactgac ttccaggccg cctcgcagcg ttgggcaacg 2280
cgccgctgaa ccgagtccaa actccagaaa gctctgaaac atccagaagc ccctgggggc 2340
gggtgtgtgc gctccacgcc agtgtactcg cacgcacaga gctagctacc caaaccatac 2400
gagtttctag ctgatattta acgccggaga ggagcggagc ctcgccacag tgagggtctc 2460
taggcttaga ggacaattaa gtcttctaga agcgggcgag gaggcggaag gggagaggag 2520
gtggcgcgcg cccacttacc attcctgagc agaggctgat gacggccgtg tgctcggagt 2580
tggtattgac atagcctttg tagaaacagt gcttgagttc cgcttcctct tcggaataaa 2640
acttggtctg attcaccccg ggcgtcccga ggagggtgac agtgaacagt ggagcgataa 2700
atccggcatt ggcggtgaga ttaaatagaa actgctggcc gaaggcagag aggcggtaat 2760
gcgcctggga ggaggtagag gaggaagagg aggaggcgaa ggcaggccag gggtcagtgg 2820
cagagttaat gctccgtcgc gttcttttga agtggacgtt cgtgggaaag ggttctccga 2880
gagcgttcac tcggatggga gacacgattt cgtattcgct cagggtctct aataatttca 2940
ctgcggagag aagcagaggt atatgaacca ataattcatt tttccttaag ctttaattta 3000
aaacgaaggt ggggactttg ttctgacctt attttccagc ccattcgagt caatcccttc 3060
acccttaatc agtggacaaa tatttgctga gcacctacta tgtgccagta acaggacctg 3120
tgctaggtgc tgaggataca ctattccgag ccagacaatt aacaagtcaa aatatatatg 3180
atttcagata ttgataaata acctgaataa aataaaacat gacgctatct ggtgccccca 3240
attactaagt tactttagtt tgcggcgtgg gagtggggat ggggatatat ctggcaacag 3300
caaggtaggg gggggttgcc taaattcgtt tccatagtgt ccctccctag caattggttg 3360
gggatgaccc aaagaaggga gaggctgcaa agcgggagat aattctttct aggaaaagga 3420
gagaagcctc cgctgcgggg tgcccctgcc caggagcgag gaccgggagg cggcgtcggg 3480
gccggcgggg tcccgggggc cggagcctgg ttaccttgcc tcgggtgcag cctgtccttg 3540
cgcacggccg ccgcggcgtc tgggctcccc atctcggcca ggtcccgcac caggagcgtt 3600
agcagtgtgg cccaggatac aaactgcatg gtgcttccca cccctccctc cgctgccccc 3660
acccccctcc ctcctgccct ccttggctgc ggcggcgacg cgaggcagcg gccgtggaga 3720
gcgcgcggag cccggcgccc gccgccaact tttgacttta ggagtcgctg aggtctcgct 3780
gcgagggtcc cgtctgcgct cggctgagca acgccgccgc ctgccgagag ctgagccgct 3840
cgggccgcag gaggagccgg aggagcagga ggaggaggag gactggggct cggctgcttg 3900
gccgcataat gcccagcgag cgggcaggag aaggcgagga acttgcgctc cgaggcgcgc 3960
cgggcgccct gtgctggccg ggatagctga gcggcttctt gaatgggggg ctgggggggc 4020
ggaggcgggg gggccgcggg tccacagcct ctcaaatgcc cccggtgcac gcctctaaga 4080
ggaggagagg ggaggagaaa gcgagacgaa cggggaccgc ctccttccag accatgtccc 4140
ctcctcggcc ggcccgtgcg ggactcgcag ccggaggccc tgccggctgc aagaggcgga 4200
ggccagaggc gtcaccagcg ccggggcagc tgttcctggt ccccgccacc tcgctgaagt 4260
ggggttttct gagattccct gccccgggga gggaaagcag ggaaagttct ctccctttcc 4320
tggcgcgcgt gcagccactt cccctctcgt ctttttcctc tcctctcctc tctctcctcc 4380
cttccgagtc tctttttcct cctccccctt gtctctctgc tgctgtgcct ctcggactct 4440
gtcccttctc cccattttcc cctgtgatgt ctgtcttctc cccgccccac cgtgtccctg 4500
tctgtttctc acatttctcc ttttcctttc ctttctcttc cgtccccatc tcttgccacc 4560
agtccccatc ttttggtttc ttacaagtga aagtggccca gcgccggagc gccttccctt 4620
cctacacttt ttcattcggg aagagatttg gcacctgagc tccgctctcg atttaatcac 4680
cccaagtcaa gagttttaga aatggggttc ttaatcctgc aggtcggagt gtgtttctaa 4740
tacgtggtct cttgaaaatt tcgcaaaata tttaagctgt gctttccacc aacctctgtc 4800
accattcatg gagggtccat agcattctgt aggtcccctg ccccaaaaaa ggttaagaac 4860
aaattttggc agcaagaagg ggcggggact ctggcgcccc tcactaccag ggggtttaga 4920
gatgggaggg gaagggggga tggagtgtaa agttgtagat ccctgtggga ggcaccagtc 4980
cctggaggga tttctcaatc acttccgctt gctttcagcc tgagagatgc ttggaaagac 5040
tgggaaagac tgaaagcagg cgcttcaagc tacaccttcg tgtgtgtgtg tgtgtgtgtg 5100
tgtgtgtgtg tgtgtgtgaa ttgttcaatc ttgggtggtt cagtggcgcc ttttctttaa 5160
ccagccctca ggaagataga atttcaagat aatttcaaga ggaaagacat gacaatatcg 5220
ttaaaaatat ataaatatat gactaataaa tatatatttg cccaagtatc ctagaacggg 5280
ggttgaggtt ctgttgcgtg gtaggttagc actcaggact agaaatacca aagattgcca 5340
acaccaggaa ccaaatcgca atatgctagc aatgtcaact attcttgaga tactaataca 5400
tatatttctt ctggtgaagg gtaaaaatga cttggcaaga cgaatttgct aaataattgt 5460
taacccaaat tgataatgtt accatcgtct tattactgga atttcataat ggatatgtaa 5520
aatgtaagga tggaaaaata acatctgtat tgtgcacaat tagagatttt tagagaatgg 5580
catttaaacc ttgaacctcc aaattaattc actaaaatac gtttcttcta atacacaatc 5640
tttcttttta ttataacaac attccccaca atcacagtgt ctgggagttg ctgaaaattt 5700
agtaaggaac agaaaaatat caagaaatca atctattggc tgattcctgt ggaaaatatt 5760
ccagtacttc cattgtaaaa ttactcaaaa atatagcact ttccagtatt tcccattaaa 5820
tctttttttc tctttcagtt caaatccttc ctgacaaaga gaagttaact aatggtatag 5880
aaattacgat atgtagggac 5900
<210> SEQ ID NO 220
<211> LENGTH: 3400
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_40164 genomic DNA region
<400> SEQUENCE: 220
tcaattgata gaagttgagt aagatgacag agaagtgact aatgtatttg gaaagatgga 60
gttattactc ctctcggcaa gacagtttta ttagatcggg agctcctcca ctggagctga 120
agagagaatg gactgtgaaa gtggagatat gtatagacat ctcaaaggca gcacctgatc 180
cttgacactc tctcctacct ccttctctct ctaaattttg atctctattg gcggcccaag 240
ctagaaatct gggagacact ctcaagtctt tcctctcttt cagatcgcat aggctattat 300
ttacagttat tcccatttta cctcctaaat aattactgat tttcttctgt gccattcctg 360
ctttttattg ctaacaggcc ctcgtcatct ctaatcgtta cgactgcagc atcttcctaa 420
taatcctcac agttttcagc ctctagcttt gacgccctca aaattctgtt agtaaagcct 480
gagggctccc agaaagcgac gatggtgctg tgctggcaga ccgaatgttt tttaaaacac 540
aaagcttgca gtcctgctgc tgtgctcaaa atccttgcat ggctcttctt gaaacaggtt 600
tagtgtttct actcgagttc cttctctgtc gttcaacaca aacacataca cacccagttc 660
tgtttcacgc ttttgtcttt attatccctc gtaactgccc gccctgcaac caacccgctc 720
aaacaagcac cctgactggc gcattcttac tcattctagc ctgggtttca acttcaagga 780
gcttcagcgc ccctcactcc cttgccctga aagctggcta aactacgcac cttttctccc 840
cttttgaaat gacctttcca gatatttcta tggaattcag tgccattttc tgccgctgtt 900
ctcaccacat tcattcatca tgtttagttt taaaagtacc agattctgtc gatttctcca 960
actgaactct gaaatctttg aggtcaggga gcttgcctca ttctattttg tattcccagt 1020
acgtgacaca tggctggaca caccagaaat tgtccgatca agtttgtggg tattaagagt 1080
ggtcaaagac gctggggagg gcagtgctgg gagaagggca gcgcgcgtct tggcgacccc 1140
agcgcagttc gaactactcc ggagtctggt gtggagccga gagggagccc cgcacttttc 1200
tccccgcgga gctgcgctga gtctgaaata ggtgtacgcg tcagcggggc aggaaacgga 1260
aagacagtgc agtaattggt ggaaagctgg aagtgggcac ctcgagggcc tcagccccac 1320
gaacacagtc acccaggaaa agcgaaccgc gccaggccct gtcatcgacc gctgggtccg 1380
tcctcccagc gctcgcggcc gctcacatgg gcgtggccct gcgtgacctg ccggggcgtc 1440
acgtgagctc ccggagtcat gtgaccgccg tcttgacagt gttccacggg cgctgcttcc 1500
tgcctgggtt tggagttgtc accactttcc cctctccgtc tcctgcgggc gcaatggagg 1560
aggaggatga ggaagcgcgg gcgctcctgg caggcggccc tgacgaggcc gacagaggtg 1620
ccccggccgc ccctggagcc ctgccggccc tctgcgaccc cagtcgcctg gcgcaccggc 1680
ttttggtgct gttactgatg tgcttccttg gctttggtga gccggccggg tgggttgggg 1740
ctgatcttta aggaattccc gactttctct tcgaggtaga tcgtcatcgt ggtcactggt 1800
gccacggggc ctcagcgcag cttctgtctt aagctcctgg gcctccttat tttccccttt 1860
gcgatcgatt ccagccacac ctgtggatgt tgctagttac tccgcgtccg gaacgtggag 1920
gtcgagggac tgagctgggc gagttttgtg gcactccttt gctcttcagt aagtcccagg 1980
ggctagcgac tcgccctaga ggcgatagat atgaaggtaa ctccagattt tcaaggttcc 2040
tcttttggca cacgtggtcg gaggaaattc agaaagcttt aactgttcct aaacaacttt 2100
tgtttgtttg gttttaggtg agacaggggc ttgctctgtc acccagcccg gagtgcagtg 2160
ttgtgaaagt ggcttactgc agcctccacc tcctgggttc aagcaatcct cccgcctcag 2220
cctcccgagt agctgggacc acagatgggg cgccaccaca cccggcttta ttattattat 2280
tatttttaga cacagggtct tacaatgttg tccagctttt aaaaaacgtg aatgatttcg 2340
tcggcagtct tctatatatt tttcaccctc tttgagaaaa tgtatgagtg tgtcttgctg 2400
atagcttcag tgaatagata ttgttctctt aatcttccac tctgccactg tgaagcaatc 2460
atattggacg ggacttgtgg tagtcttgac agtggttggt ttctcttatg aaatctgatg 2520
tctccgaaaa cagtttcttg ataattagaa aaaaattttc cttcctatgt tacagttttt 2580
aatttattaa gcaaaattct aatattaatt tggtatgaat gtgtttttca ggaggctagc 2640
tggagcccgt gtaatcagca ggtttaagaa cattatggtg gataactatt ctagcgctga 2700
acatataagt agacatgaag gatgctttgg gctttggttt ccttgcaact cctttttccc 2760
ccctcccctg ttttttaaaa gatgatgccc atccattagc tttaaagcag gacgttgaat 2820
ccttaaaaga gattaaagca gggtttagaa acaaccacca ccacaacaaa gaaagaacaa 2880
caataaaaca ttaaaaaaaa tggtccccac tcaagcagac agacagtttt tggtaaattc 2940
tggttatctg cctagaattc agaagccaga ttcattcctt tctaatgaca gtttttattg 3000
tcattagaac caatagcctc gtgcacttgt agagttagta gagctatgga ggcaatattt 3060
tcttgtagcc tacgaaggaa tctcaattat tttatcttta aaataaatcc gagtgcatgg 3120
tcagatctct ccctacttct ctctttccag ttcccccaaa gacatgtttt aatttaatcc 3180
tttagaattc tcagtttcat ttttttttca ctcctggccc tgtattcact aaattatttg 3240
attttgggta gtttgtagaa ttagagaact tgtttcaaat attggttttg tcagaatggt 3300
tacactccat tcctttgtcc ttaagctaac attattagga aactgatgag gttgtaaagt 3360
ttttagtgta tgtgtgtttg taaataagga aataaataaa 3400
<210> SEQ ID NO 221
<211> LENGTH: 1700
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_23178 genomic DNA region
<400> SEQUENCE: 221
ttttgggaaa caatacagtg atctatatca agacataaaa atactcacat cccttgactc 60
attctctgga aatgctgaag gaagttattc aaaagaggaa agaagctata cccaaaaagt 120
tattcattgt tgggtttttt ataacaagta ttggaaatgt ttaacaatga gggagggtga 180
acttaaccac ggtacatccg ctctgaaata ataccacaac tataaaatag tgctgatgaa 240
gagaaacaat gtaagaacat gtttatcata aaattttaag tgaaaacaat atatattata 300
caaaaattct attcacacac tgattataat tacgctgaag gatgttggca ggtgggtgaa 360
aactgaaaaa aaaaaaaact aaaaacagtt atgcttggtt ggtgggcccg taagatgttt 420
atttccattc tgtttctgta agattctcag agtgttggta ccgcagattc aactggggcc 480
agagaagccc atcacgggag cccgaggaaa agcagccaca gctctccttc ctagtacaag 540
cattcaacag taagctccca cgcaaagaat cagactgcag caaatttcag cgctgcctca 600
ggaacactgt ccttggctcc cacattgcaa agattttcca ttccctccac agtcacctca 660
ttcatggtta aggaagaaag cgcagctaac agacagggtg acgacagatg tccaggcact 720
gagccatcca tagctgttat ttttcattca cataggcatg tgccggatcc agcagatgaa 780
aaccagacct acccccttcc ccatgtgtgt gtgttttttc cccttactgc tgctgctgta 840
acagctaagt gccaattatc tcccaagcgt gaaagcaaat attgtgatag cccaacaaac 900
tctacaaatg ttagaggaca caggtgggga tgactgtttt tctgtcctgg ccttggcatg 960
tctttattca ttgtaacagc tctcattaaa ggaggatctg gtaggtgcaa agctttctgc 1020
taacaccttc agcactttgc attctttatt ttctcattta tctcttggca ttttgttgtt 1080
gcccgtatcc ccacgaccca cgaatccaga ggtaagtttt gcttttcttt gcctagaaaa 1140
agctccatta aaccacctat tctcaggacc caacttcaca tgggctgata tgaatacttt 1200
cttcaaatat ttgaaggcct gatgtatcgt agtattgtat tgcagtaggt agtattgtag 1260
tattatagta ggtgctttaa tcagggtttt ccagagaaac acagccagta ggagatgata 1320
gtcatagaga gatagataga tacatacata catacagatt tatttttcag gaattgaatc 1380
acacaattat agaggccaaa agtctaaagt tttcagggta ggccagtgag ccggagaccc 1440
agggaagagt taactttaca gctagagtct gaggactgtc ttaaggcaga gttccctgtt 1500
ccttgaggga tctgtctgta ttttcctaag gccttcaact gtttggatga ggcccaccca 1560
cattatgagg gggtaacctg cattactcaa aatctactga tgtaagtgtt gatctcttct 1620
aaaaatacct tcacagcaac atctagagtg gtgtttgacc aaatatctgg gtacctggcc 1680
tagtcaagtt catatataaa 1700
<210> SEQ ID NO 222
<211> LENGTH: 2000
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_46057 genomic DNA region
<400> SEQUENCE: 222
cttcccttat gtttgcaatg attatgaaca gtttagttag aacctttatt tgttgttttg 60
ccttgaagtt actggactgt tgcttagctt gcaagtcttt tgtgggtttt gtatgttggg 120
gaaggggatg ttaaaaatgc aggctgctgt gaattaatga gttgcctctg tttatagaaa 180
tgcgatgatg ttcaataatg atttgatggc agatgtacat tttgtggttg ggccaccagg 240
tgggactcaa cggttgccag gacacaaagt aagcaacagc tgcatgaccg gtttagtcct 300
gacgtttaca aagagggacc ctttccataa gcctgtaact tggtgtgggc agcttgccga 360
tgtcaggcag tgcatgtttc actcgattag ggagagagcg caccctctcc agagggcttt 420
ggccacgctt aattttttct ttgtttcctt ctatactgct ttatatctca cacatcccct 480
cttaactctc cagacatggg aagttgttgt gacaggtcag gaaagtcgta tgtttaccct 540
tctcctagaa attagttatg taagctatta ttgtatgtat ttagtaatga ggggacatgt 600
gcattaatct cttaaagctt tgaaataatt agcagcatgg tcttatgctt ccatggcaag 660
ctaccctgtg taccttggct ttttcaaagc agtagatttt aggtacgcta tgtttactaa 720
acctgattgc ctagtgttgt ttttctgcat tgatttgctg gaaatgcctt caatttagtg 780
tatgaaataa gatttccctt tctacacagt atgttttagc tgttgggagc tctgtgttcc 840
atgcgatgtt ttacggagaa cttgcagagg acaaagatga aatccgtata ccagatgtcg 900
aacctgctgc ttttctcgct atgctgaagt aagcatcatt cgtgtgtttg gaaagagttt 960
gtttatgctg tatttgtacc ctgctggttt cacagttaaa tttaagttct gcataacaga 1020
aaagaagact gatgaagaaa gagggtgctg cttaccttgt aaatgttttc ggaaaagaac 1080
actttagctt tccgtggaaa gcatatggaa ttatgcagca tttataatcg caccttgacg 1140
tagaatttgg gagcaagtgg catgtatagt gatgattttt aacaacttaa aattaaagac 1200
aaataacttt ctggtattag cattatttaa tagaagatgt tctctctgaa agcattgtgt 1260
gtgaaaaagt ctttaaacaa atgtttttgc ttcacaattt cagaagttaa gtaccttatt 1320
taagtaacac cagttgggag atttctgagt attctaagag ttattgtctc ctaagagcaa 1380
atgaaaaact taccatctgt tgaaataatc tgatctttgt gtacacatac atatacatac 1440
tcatataaaa tcagacactc tcaagggtaa aaagtacttg catttgacat tacaggggaa 1500
atcttagaaa gatatggata gtctcgtaca gtttcatgtg gatttataca gaagaacttt 1560
cattggtaat acagaagtat gaaacttaaa gatacgttat atatttataa aaaagatagt 1620
tttctgtctg gtgggtcttc tgcaggcacc agtatgtgtt aaacaggtta tagaatcagc 1680
ttctttatca tgtacggtac tagacagtgt ggtagttcac caagtgatca taatctaatt 1740
attattctaa gtagtattta tatgattttt cctaatcttt attctagcac agcaaagtgt 1800
attactttaa ggttatctgt tgctctaggg atttcagttc attggaataa gtaaaatgtt 1860
tgttgaaaaa agtattcagt gggtcaacaa gttggacagt actcctacat atagttaaaa 1920
tgttgccata cattgtttac tgtcttctga aaaataagta ctgtagttag ttctagaact 1980
taaaagtatt taattcatta 2000
<210> SEQ ID NO 223
<211> LENGTH: 2300
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_40959 genomic DNA region
<400> SEQUENCE: 223
ccaagatttt aattaaaaca aggtagtaaa taaatgtcaa aataagtggg atgagaataa 60
cgtttcattt tcagaagagt ccatagggaa caattcagag ataaatttaa tcacaaaagg 120
tctgagaatg ggaatattcg gttccaccct ggttttcaca tctgttcatt ttcactactg 180
gttgcgtttc ctacggagac tcgggtggaa cataaaagtg gggctacttt ggacaaacca 240
ttaaaaacct tacccttttt tctcgctaca cacaactaga ccacattgct cttagctaaa 300
gggacacctt aaatctattc gttcagcaaa acttataaca ccgtgttcct tttctactca 360
gagggaatcg cacaaattaa ttcttgcaga tactcagctc tcctgttttt taagcttcca 420
cgtgggcctt agccaaataa cttctggtag gcaaattctc cccttcttca gttgagagct 480
cagagcaagc tgttggatta agcaaaagca ccttttaaaa aattaatatt caaggcagct 540
gtaccgcgga gggcctgggt ctcggagtct aaaaaatcag actggacgtt actatttttt 600
tttaggcaaa cgacagctcg tttctcattt gtaaaaccgg gggaacatct taccgaataa 660
accttacaca aacagaaagg attcctaagg gctgggaaaa tactattttg ctgtccccag 720
gatggaatat cagcatcctt gtcttttagc tcttaataaa gctctaacta gtcacaggag 780
gagccaggct gcatgatcac gcacactctg gacgtctagg ttttccgacc taataagggg 840
gcaggtcgcg tcgttccctg cttaaattag agaccacctc cacctgccaa gggcccttca 900
aaccctccgc ccctaggtcg ctaacgatca ccgctttagt tctagctcca ggcgccgcct 960
ggcggctgtc tccggaagtc gcctgcgagc ctcggggtcc tgaccgctgc tgggcctgcc 1020
cgtagatttg cctgactcta gcgaacctgg ctccgcccct cccccactat acgttgagga 1080
ttttaagacg gcgatgaaag ggctgaggtt gtggcgacgg gggcgtccag cggcatctcc 1140
actcccccaa ggatggcgga atcaggccgt tgtcgggcag ctctcgaccc ggaagtcgct 1200
cgcggcgcga ggcccccgtt gccgagcgcg ggcgcggggg gcggagctcg gcggagacgg 1260
ggaaggggtc gccgtggctg ccggtcctcg agttgggggc tgccgcggac actgctaggc 1320
agacggcgag taccgagcgc gggtggccgc ggtgtccgtg ggccacgctc agctgcggtc 1380
agaggcgaca tgagtgccgc ggggctgctg gccccggccc cggcccaggc tggagcgccg 1440
ccggcccccg agtactaccc cgaggaggat gaagagctgg agagcgccga ggacgacgag 1500
cgcagctgtc ggggccgcga gtcggacgaa ggtgagtcct gccgctcgcc cggccgcccg 1560
gagcggaggt gggaccgctg ggggaggggg tggggctgtt cgggagaggg gcggggcggc 1620
ctccggggcc tggggctgcg tggaggggcc gccgggagtt gcggggctcg gggaagttac 1680
ccccatccgt gctggagtag cggggaagcc ctgggtgcgt tacactcgac cgtgatgggg 1740
agaggggact tagatgttgt cacgctgggg gtccctttaa gaccccgtcc tccctcccag 1800
ccgtttctga ttgaacctca ctcactagta ggaattagaa actcatttac tgaatacatc 1860
gagtgtagtt cgcccctttt ttgtgtgtga gagcatcaga gtccaaagtt gcccctcccc 1920
acccccgaaa tgcataagtc atctatactt taggtagtac actattgaga actcaggttg 1980
gttaaaggaa agggacctag aaccagccag atacaggttt aaatttggct ttgtcactta 2040
actcagcttt gtaaacttaa gttttccagc ctcgatttac ccaactgtaa tggagctgtt 2100
taattcccac acctgcccta gaaggcactt cctagggtcg gtatagggat taaatgacat 2160
gcgcataaag tacttggcct ggtactgtaa atactccgta aatgttctcc ccacccgccc 2220
ccctcccgga aacaggtaag agagggagag atttgcttaa tggtccccag gtgttgtgtt 2280
ttcagtccca cgctctttgc 2300
<210> SEQ ID NO 224
<211> LENGTH: 4100
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_104423 genomic DNA region
<400> SEQUENCE: 224
caggtaagaa aactaatctc aggtcaactg gagagggcag atctggagaa ttaaatgcct 60
gtgcagtggt gaggggcgtt ggtcagattc cttgcctctg ctcagaggta gtgtccatct 120
ttttgccttt gtcacttctc cccgggtctg gctgttgttt gtggctgcgt gtagagcttg 180
tcaggcggag tgctgtgaca ggaggctatt ttaataaact gttgcagttt ctcgagccga 240
gctgtgttgc gttggcatcc ctcgtcaccg ctaatggagt gtgcgtggct gggtgtgggc 300
cgaaggagga ggctgagctt gctgggggct gggggagaag ggagggacgt gtggggtgct 360
ggcctccccc ttgtctgaga gtgctccttc agcagccaga cctgggggca tcacaaggtg 420
gcagtaccct gggcaccaga tccctgccct ggaagtactg ctggcatgga cactttctga 480
gctctctttc ttcttatttc tattcatagc accgcaggcc cgtgtgtatg tggccgggga 540
ggaaaacttc cactcgcccc tgtgtgctcc ataggaagaa aaaaaaaaag aaagaaagaa 600
atagaaacag aaaaagagag tgtgcaggcc cgagagaaag actgaaacca aaacacagag 660
agaaggcgca gctgcttccc caaggccttc tggggctccc gcccgccagc ccgccgggag 720
tcaggccttt atttatttat ttttcaggct taaaaaaaaa tttcgagtct tccacaatcc 780
cagtcccccc caatgcccca ccccaccccc agatttgctg ggtggctgct gccaaatgga 840
cccgagtggg agcctggaat gaaaaattca taactgctgg actttgcttg ttcattagac 900
gtgaacttgt cgattgggca aattgttttt ggtctccaac tgccgggggc tctccccacc 960
ctccctgctc gcccggttcc ctcctcccct tggacgcagc cattggctgc tcgtggatgt 1020
ctctttgcca aataggtgga tccttctctc tctttctctc tctctctctc tctctctctc 1080
tgtctctttc tccccccacc cctttttact ggcttggcac aagcaaatgg atggggattg 1140
agcctgaaag gagagagaga gagggagttt gagagagaga aaaggagcaa aaaaaaaaaa 1200
caccccaaaa acccaaccag tgcgcacaca cacgcgcaca ctcacacaca cgccccatcc 1260
catccacgtc ctccctcgat cctcgatctc tccctccccc ccttcttcct ttcctccctc 1320
cctcgctccc tctctctctt ttgcacgcgt ctgccagcaa cggtctgcag ccggtcagaa 1380
ctcgtcctct tccccgggaa tctgcgagct cccccttttc ctccgatcag gcagctcgaa 1440
gtttacaccc ctgtgccgct gccaaagccg aaagcctttt tcttcagctg ccgctttttc 1500
cctcctgggt tttgtttttg tttttgtttt gcacgggggt ggggtggggt gcgttgttgg 1560
ttgtggggag atggtgggag gctggttttg atttttaaat tttgcatttt tttctttttt 1620
ttttttttta aactggaaga ggatgcacag gggaagaaat tgaaaaaaaa attttgttgg 1680
cttttgttta cctggcgtgt gtggcagccg gctcgctccc tctctctgct tgctatccct 1740
gacctttctt tctttttgct ccttttcaaa aaaaatatta atttccccct tctgtgcaat 1800
ggagcatggg gggggggagg agggggaagg gtttgagaat ccacccaagc ccggccccta 1860
ttccccagaa caccaataat aacccccttt aaaacattta ccttcctccc ctgctcctcc 1920
tcctcccccc tccccccacc cgcccccaac tcacaactct tttgagtcca gaatctcaga 1980
atcgggcgtt gggctttgcc gggtgcttca gatcaatggt aattatttaa ttttttccag 2040
ttttattttt gtaaacagaa atcaattatt atttaaactt caaacaagca aacaaccaaa 2100
aaaaaaaaaa aaaaccaaac aaaaccgaga gagcccatcc ttctgtcacc tgactgagtg 2160
ggaaaaaggg tgaaggggtt gtgggaggct ggggaagggg tcgcaagaag acccatgtag 2220
cttttaaccc taatgtggcc gagacaagca ccttatttgt gctaacaaga agtgttttgt 2280
tcattattac tgtgattaac attagtattg gtgtcgataa caaagctgaa atcacatatt 2340
taggatttag gtctgattaa aaaatgttgg ggtggatgtt ccaactggat caggagaaaa 2400
gaaaatgaaa acagcctggg gagagggaag cctgatctgt ttcctcactc gcttgctcgt 2460
ggatgtcatt ttctgtcttc ttgggggcgg ccaaaaatcg accggtgtcg gggaccagag 2520
gcggccccgc acgcccccgc gtgtgcgtcc acgggcgtct gtgcagacgg acactgtgcc 2580
ggggcgagct gacaggagtt cacggctgcg atagaacatg gagatgtcat gggcgcgaca 2640
gagcctggcg gggataccag cagcgtgtgt gtgtggacgg caacgttgtc tgtgcgcgtg 2700
tgtgtgagtg agtgagggag agagagagag aataggtgtg tgtagaggct cccggtgcct 2760
ctgtctggct gctgaggctg agatgggagc aagtggctgg cgaagctggt ggtggcttca 2820
aaccacactt tcgtagaaca atcgcaagag aaaattgttg gggggaggga ggaggaggag 2880
aaggcggttt tccttgtgcc cccccttcta acgctgcttt tctccttctc tctttccccc 2940
tcatcccgtc ttcccctcct cccgtcctcc ctcgccccgc atgctcccgg cttgccgcct 3000
gcaggatgag ttccacccgt tcatcgaggc actgctgcct cacgtccgcg ctttctccta 3060
cacctggttc aacctgcagg cgcggaagcg caagtacttc aagaagcatg aaaagcggat 3120
gtcgaaggac gaggagcggg cggtgaagga cgagctgctg ggcgagaagc ccgagatcaa 3180
gcagaagtgg gcatcccggc tgctggccaa gctgcgcaag gacatccggc ccgagttccg 3240
cgaggacttc gtgctgacca tcacgggcaa gaagcccccc tgctgcgtgc tctccaaccc 3300
cgaccagaag ggcaagatcc ggcggattga ctgcctgcgc caggctgaca aggtgtggcg 3360
gctggacctg gtcatggtga ttttgtttaa ggggatcccc ctggaaagta ctgatgggga 3420
gcggctctac aagtcgcctc agtgctcgaa ccccggcctg tgcgtccagc cacatcacat 3480
tggagtcaca atcaaagaac tggatcttta tctggcttac tttgtccaca ctccgggtag 3540
gtcgttctca accatttttc cctctcattt tattttcctt gctggcattt gttctgttta 3600
ttgttcctct aatttccaag cgataactcg ccatgggcct aactggtgta tgcccgtcct 3660
gcggggcctg caacacggtt ctatgggccc ttttcctttt tcctgtcttc tgtctccccc 3720
gacctgttct attcttcctc ctctgccccc tggccatggt atcgactttg tgcatctcca 3780
tctttggagg acttatctga tcagaaagat gctgcaggtc ttaggattgg ggacatgatg 3840
cccccagaat tatccatgat ggtgagagtt tgagatgaac aacaacagca aaccagtaat 3900
tgctcttatt aaaatgagtc agaagaagta ttgaggggca ggtgctagtt ttactgcagc 3960
ttcacctcca gtcccaggaa aaactgggtt tggtacaagc gggatgggca ggagtccggt 4020
ggagagaagg ggcatgtgaa accctgggat atgagactga atgaacagaa aagaggagag 4080
aagacagtag tgggcagatt 4100
<210> SEQ ID NO 225
<211> LENGTH: 5800
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_00847 genomic DNA region
<400> SEQUENCE: 225
ataactcatc agggtgacag agccacaagt gaattctctc ttctatcaga gagtatccta 60
tccaaagggt caggaaaagg ctctccctaa cattttccct tccacaacca agtaaatagt 120
ccctgaatat ggtatccgct gcttttttaa atatcaaagt ttcagaaaga gggaatgcca 180
gacgtgcaga atcagaatgc aaacgtaccg aaagtattct ctctttctca agatgtgttg 240
ggggacaatc agagactcgt cttccacccg taggaaatca ctggcttgaa ttttaggtat 300
ggagtgctgc ctaacggctt tagtgtgctt gtgctacacc tgagtgcgtc aaagcttggg 360
gggaagggag gacagcccac cgagctgcgg taccccgctc aggctagaag agcgctaggt 420
aaggggaaca tccaaaggga cgcaatgaat tcaaaacctc tctttcccac cgagatctgc 480
agtcctgggg gtcgaaaggc ccacctcaaa ggaaccactg ggttattaat ttgatcagcc 540
aggctggctc ttcaggctgg gggaggggtg ggaatgggaa gccgccatcc gtgctcatgc 600
gcaccccaac actcaagctt acccccagac ccctggattc tgcccacttt ccctctcatt 660
tcacctcaaa gtcaatggag ttaaaaatca gtctctttcc cctacttttc ccggggagtc 720
tgaattcctg gggtctgtta atgattttaa aatgtagagc cttccctggg tcgctcccgc 780
ctggagttcc cgcccccttc cctcctctcc tctccccacc gccaaccccc accgcaacca 840
ttctcttctc tctgtcccta gagaaaagcc cgctacatcc atttggattt atgtaaggtg 900
gattagggac acaaaggaaa caataagacc caatttacaa aaaaaggagg gagtagaaag 960
ggagggtaaa agagagaaaa ggaaacgtga tgggaataga aagcaacaaa gtgaattaat 1020
ttttaagggg gaggtggggg aggggagggg aacagacctc cctccctccc cttcaacatt 1080
agcctagggc tctcagagcc tttttgtctt gggctcccaa gtttttctcc ccccccccca 1140
aaaaaagagg gggtttaaaa aaaagaaaga aaacagtctc tacatctggg gcgagagagg 1200
tctcagggga cgtcctaaca agtgtgtgaa gtggccagga gaacgcggga tccacgattc 1260
ctctcagggg aatgaataac cctagggacc gaggggcggc gacggccgag atggcaccag 1320
aaccaccaga agccacgtcg gaaggagatg ggagatccag agggcgagag agggcccctt 1380
tcctcccaag cgatgtctgt gggcaggtgt ataaatctct cagagcctcc gtctggaggg 1440
ctccgggtac cggctgccca gccaaggcta agttggtttt tggctccctc cttcggaaca 1500
gagaaaacga tagattacac agggatggat ggacggatgt ctggagagat ggaaagatga 1560
atggatggat ggatgggtgg atggatggat agatgaatgg gtggatggat ggagggatgg 1620
atggacggac ggacggacag atatatggat ggatgcatta tggatggatg catggacgga 1680
cggacggatg cacggagaga tggatggatg catggatgga tagatagacg gatggacgga 1740
cggatagata gatggatgcc ggaaaggaga agaatgagag acggatgtga gactagatgc 1800
acgcaggcca gagcaccagc atacgctgga acagagcacg agcatacact cgaacacacg 1860
cgcacacact caggacatct gcgcacagac atacaatcct ccgcgtccgc ttccacgcag 1920
gcattcgcgc acctacatac acgcagttgc acgcgcgcgc acacacacag gcacacacac 1980
gcagacatgc acacacacgc agacatgcac acacaccaca catgcagaca tgcacacaca 2040
cgcagacatg cacacacaca ccacacatac acacacacac acacacagtt cgcctctccc 2100
tgggtttctc agaaactaaa tgatcaccgc ccccccgccc cgccccacct cccgacacag 2160
acacacaggc acatacaatc ctcccagcac gtccgaacgg atgcacagaa aactgagcac 2220
ccagacgggt cccgtcgacc ccgcacgtta gctctaaact gtgtgcaatt ctggggcgaa 2280
aagctaaaac tcgactgcgt tcaacttgcc ggcgggttcc ccaagtctgc ggggcgaaga 2340
gctcgggccc ctcaggcccg caatcgcacc ctcggggcgc tgggcttggc gaggagaaag 2400
gtgtctgact ccgggtgcta gaaatcaggt cactggcgcc tgacgagcgg cgccacgacc 2460
gctgcgctgc ggagcaggcc ccgcagcccg gtcccgagaa gcgcagggct cgggaaactt 2520
tgcagaaacc agagctcgaa aggctttcgc tagaatccgg gagcaccaag ccttcactgt 2580
gctccaggct gcgttttccc ctcgccccgg gctggctcag gagaggacgt ggttcttgta 2640
attttttttt taaatcccgg cgttgtctcc cgtgcatccc ctcagggcgc ctcgagcggg 2700
cctctctggc ggatgctgat aaactttggc ctttggttac aaacttggac agacccgccg 2760
cgtgcacggg tcaccgcctc ggggcaggct gtccggcggt tccccgctgc cccttcgccg 2820
atcccctcgc ctcagccccc ttctcccgaa tcgggacgca ccattcacac tgggctcccc 2880
ccgcaccacc tggccctgcg ctcctgagga cccctcaccc gcgatggccc ctcgctgtcc 2940
ccgaccacag aaaggccgtc ccgctcttac cttcattcgc ggggtatacc ctggaacctg 3000
tgacagcgtc gcaaatcccg aagagacacg aaaatagggc gaaatagaaa atcccagcca 3060
tggttcgccg gtgccaacgc tgctcctgcc gcttctatcc cagtggaata aatgcttaag 3120
ttaggagagc agcgggctga agacattgcc aagggggcgg gcccggccgg tgacgtgagc 3180
ccgccagtcc ggggcccgcg gccaatggcg gcgcagacag ggcggccgag ccccgccttc 3240
accgagcagg gcccgcccca gggttccgcc ccctccgggc tccacggggc gcgcggtctc 3300
ccggggctct agggggcgag cacggccggt ccccgccccc gcctgccgga gggagccagc 3360
gggatccccc acgttacctc gaaggtcgag cccctggacg gcggagggac tttggaaaag 3420
ctcggaattg accgagggga gccagagaag aggttggaaa ccttttctcc caccacgggc 3480
ggtttaagat ggaggaaaac gctcttttat tgaaataaaa gaagtctaag ctgacctgcg 3540
gttgcttctt taggagagtc gacgtgtctg cgtccagcgc gcccgggctg agctgcagac 3600
tcgcgcctgc caccgccacc ctctgccacc ttgccctgtt ttgtctttat ggcgcttccc 3660
cctctgaaat actctttgcg gggagttttg tggctctatc actcgcttct tccctggctc 3720
cccagatgcc tggagagcgg ggacctactt ggtccccaac gtccagtccg cagcagggct 3780
ccgtcactgt ctccagagac tgaacgaatg actttctagc agtaaggaag tccccgctgg 3840
ccccgtcccc ctgcacacgc cgtggacctc gcccagggcc caggacgccc cgagatggcc 3900
ttgggcaggg aaccagttgt ggatttcccg ggggcagggt tgggggcagt ccctggaacc 3960
gggcctagcc cgtctgggag cggtggggta gaagtgaaag gcttaagtgt gggtgcgggg 4020
acttgcagcc gcacagacaa ggcagaccgg gactgggaag ctgcccggag cggctgctgc 4080
gactctccgc tccgacctag ccggggcagc cctccctgcc ccgggagaag acggcgagca 4140
ggaggacccg cagagccccg cccggctgct ccggccccgg gggcactggc accatcgggc 4200
tgtggtcttt tcccgatgcc cgagccgtgg acgcggccac ctaagagcgg tccggcgaag 4260
gcagcgcagc cggtgtccca gggaccggtc cccaacgcca ctcggtgcat ttccccaggc 4320
gctggcaggg gcactgattc ctagcaatga ggcctccctt ccccttccca ggccgcccct 4380
cctctgactc cctccagagc agggccgagt tttcctgggg agcctgggtc ccggcggccg 4440
ggcggccgct gggaggtgga ggagcctctc cagccccggc cgcagctcat cgtgagccaa 4500
ccgcgccacc tgccggccag atgcgggagt gtgcggcccc ggaggaaggg cgagcggaca 4560
aagaccgcaa cccgcaatcc gcaaccccgc agagaggtgg tgcgtgcgtt tgggcgagct 4620
tttcagccac cgccaagtct cgtgcactag ggctactcct accgtggggc tgcggacagc 4680
gctcaagagg tcctggagtc tgtcgtgact ctcgcctgct ggatttcaaa agatggaatc 4740
ggaaagcgtt tcaaggagaa actcctaaca aaccttccgg gggttgcctg agtggctgct 4800
ctcggaaaag cggatcctaa ataaagcggg agggttatag ggcgacgtcg aggagaggac 4860
aggtctcgag tcactgctac agtttcaggt cactgggctc cgcagcagat cgtgttttct 4920
cccgtggctc gagagctgcg ctggtttctc atgcaaactc agagccgagc taatgacatg 4980
agcaactttt acttttacac aagatgagca cgcgtgccga ggcgctgggc ggcggctgtg 5040
tgagttggtg gcccagacga acagcttgtg cgagactctg ggcatttcgg tttctagata 5100
caagatttgc ttaaatgtca cagtccaaag aagtggattt cagtcattgt agctactgat 5160
tgcacacaag taaaaaggga aaaaatatgt actcggggga tatatgtatg tgtgtgtgcg 5220
tgcataaatt atttaaaata actgcactaa atccctttaa gaaatgcatt tctgggttct 5280
ttcatgtgtc tttctgagtt ttacagaaaa agaagacgaa tattggtccc tgtcatttgg 5340
cacacagatt caaaagagaa aagagcaatc cgaattcttt ttgaaacctt tttaaacaat 5400
agatgctggc tgcctctctg caggatcttg agtgttgcat gtatctatct gtgtttgaaa 5460
cgggaaactg actgcctgca ttgttataaa cagtaaaatt tctaaaacat gtaccatttt 5520
tttccccagg atatgcacat tgaatattaa acaaagtctt tccagacaca gctgcctgaa 5580
agcaaggcat catttgctag agtacattca ctgactttcc cttttttctt cctatgtttt 5640
agttcaggac ccaaggcagc ccgataatca ggagaaccaa gaagcaggaa atgctaactt 5700
ggaaaaactg aactataact tcctctttaa atcatttctg ggttgcagaa cagaaatgag 5760
ctgctgaaaa ttcctctgtc cattgtgact acctagaaca 5800
<210> SEQ ID NO 226
<211> LENGTH: 4000
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_08347 genomic DNA region
<400> SEQUENCE: 226
ctgctgaccc ttcctctcat catagaaaga ggggtgggca gggggcagag tccttcctgc 60
tccttgccac cacgtgggag ccagacttaa cttccttaga aaagtcatcc ctgcccttac 120
cagcctgccc tgtggcattg ccaatcggcc cagcatctgg tccacacaga tccttaaagt 180
aatcttcatt cttgaagaca aacactagtg aaggccagcc aaagaggacg ccagcaaagc 240
ccaggcattc cagcagccca gtcagcagtg tggccacgtg caggggcagg ccctggcccg 300
ccatgagcag aagtggagtg gatcttcaaa tcccactttg tcctcctgga cggatcacag 360
gcgccgtaag cctggcgttt gagcacttgg aaaattcctc tggcaagcca agcccttcct 420
ttcccgtagc tctctggttg tttcaggcct gggcaaaaac catcagcggg tgattctctg 480
gatcctgtag aataaagata gaggctgctg gaagaggagg cctgcgggaa agggaaaggt 540
agactagagt tatttgtgag gtgcattaag aggcaggatg atcatggccg ctggcagcaa 600
atgtggggaa taaatactcc aatacatcat cttaggcact gcatttgagt aaccacgtgg 660
caagtagaga ggcaggtctt gatggccacc tggagtcaca ggtgagataa acgacttacc 720
caatagctcc ccgggagcag gtggagaagc ggagctcctg cgctcgaatt ctgaataccg 780
tcccctaaaa taatgacagc aactcaacca ggtgcagagg cagggagatt tcatacagaa 840
gacacaaact cccgctgcca agttggtgtt atcttcagtt tactgacaat gaaacaaaag 900
ctcccatgga tttcaggaac ttgcccaagg tcacagggct agtttagtca cgacgcaggc 960
cattctactg ccagaaatac ccccaactcc catgaccctc gcctaggact cgcaaacctg 1020
gtccccgccg cccttcctcg catcaacttc taccaggaaa gcctccgggg gccgctcccc 1080
gccagcctcc gcaccccgct ccagcctgcg gcctgccctc cccgcagagg agcccgaggg 1140
gccaggccgc gctcggcgcc ccatggcgcc cgaaagggga cccttcgccc tacccgcctg 1200
ctccgcgccg gggctctccg cgccctttcc gcacgggcca ggttcgcatt cgcgcctctc 1260
gcagcccctc ccagtcccct gctcgcctcc gccccctcct gcccgcccgg aaggggctgg 1320
ggcagacctc ccactctcca tcacttcctt cttcttttcc cttgctcaca gcctcccgcg 1380
ccctttttac ctctccctct tgaaacttct ccctctagaa ccccctagaa ccccagcggt 1440
gtctttccct ccctcctcgc tgcctttcag cctcccagcc cccttgcctc tgcctcccct 1500
aaccaagtta gttgaatgct gttactcgct caggcccacc tagggaaaat gtcacaccca 1560
gcacccagag gacacacaga cagcacatga gggcataggg acacacacac tctatttgtg 1620
cattttgcct tgaccgctgg gttggcaggg aacatatttt tcctatttgc tcaccagctt 1680
aaccgtctct cccagtttca cactcccaga gctgccaaaa aaatcccaac cacagaatca 1740
ggaagccaag aaccaggact gagggctttt cagaaaccat cccctggagg actgccccat 1800
attttcactc ccaaaaaccc cttagatgac tccctgcctc acccccgccc cccaggttct 1860
gaaagagcct tcccgccaga ctgcattgat taaccattca ttgccccatt ttttattaat 1920
caaagacata tataattgct catcggagct tgtgatcagc gtgaggcctt actaagcagc 1980
tgccttacta tccttccagc ccagagcacg tgagctgacg tcttctttgg cctgtgtggc 2040
cgtttccttg ccaaaagctc agtttgggga gagcttcttg cgtattagat gcagtctgca 2100
gactcccaac cccagctacc tggatcccct gagggcccag gaactccagc tattccaagc 2160
ccactcctct tttttttaag aggaagaaat agaggttacg ataggggaca gccagaactg 2220
aggattttcc agctcaccac caaagcacaa aagataaaag tctgcaacca ccctagtgac 2280
ttgactgaat ggaggaaggg tggctggggt cctgtacccc aagctactca ctagttatac 2340
aacctgaggc aagctctttg gctgccccac ctgtaagacg aggacaatag taccttaatt 2400
ataggaattg tcataaaaga agtataagat gggtgtatga ggtccctgca tggcgcaggt 2460
gctataggca gattgtaggg tagtagattt tctagtctgc agttatgtag acagagccag 2520
agaagcagct ctggggagga atttcaaagg aacttgccca cggtcattct acaaagctgc 2580
agtaccttcc caactctgaa acgtatgctc tcatcacccc gtcttaacaa acatttggac 2640
attagagaaa acaagtcttt tcttaaaata acattattta tgggagaaaa tccacaaaaa 2700
tatagcatcc caggacaaac agggcttaag atgcaagatt ttctatttta ctgcaagaca 2760
caaagactct gaaattaatg catgccctat cttctgctct ggcatacatt ttagtctcct 2820
ggggggatca gtaagtgtgg aagtagcaag ggagaaacag aaaaaagtca aagtaaagag 2880
acagatttta gaatgttaat ctgcaggagc ctgccagaaa gatctagctc atgggctatc 2940
tgtacatcca ggactgaagc acgggacacg gggcaggtcg tccagggttc tgtccacctt 3000
atcttgttac ctctcttgac tcttagagcc tccactccac atctcccatc aatgtctgca 3060
gaagacgtgg cctccactaa cacaagtctt actgaactga tgggacagga aattagaata 3120
tcctctgaac cattcccatg ttctttggtt cgaattccag cagctagaaa aggcagatgc 3180
tattctgatc actctcctgc gtggctccaa tgaggattaa tgagtaacat cagagagaga 3240
agtgattata ataaggtctg acggtgcacc cgatgtcttc atccttttct cttcgcctcc 3300
ttcctcatca tctcacacct tttttttttt aattgactga ttggttcaac aaatacatgt 3360
ggtacctcag gctctgtgcc aagtgccggg attcgtagag aagagattca gtgcctgctc 3420
tcaaggggct cattctcttg tgggagagac agacaaagaa acccaagatt tctggagtgt 3480
gggaatggtc ttccaggcag atgctagcac agcacattga aaggcacgga acctcaacaa 3540
aacaataaca tttaggaacc agctagagca cagggtggtg aagaaagtgg aaagatttga 3600
ggccagcgtc gccatctaag tgagggcatt aagaattcag cccacatcaa tcaatcatgt 3660
cctattgatt tcacccctta atatctctcc tatctatccg tggccactgc tctatgcaga 3720
cactcatcat ctctcacaga ggcatcatct gcttccaagc catcgccatt ctcctgcaag 3780
agtttatttc catggttccc actggatggc ttcacttaac tgctcaaaac ccttctgagg 3840
tccagtcaac tggctggtaa ggaccagtcc agggtctggg gatgccagcc atgagacatt 3900
gctttgaggg gaagagggag catagaactg gatctcctgc atcctactgc ccaagtacca 3960
atgctggagg tggttttcct tcccatcatc agcaagtctg 4000
<210> SEQ ID NO 227
<211> LENGTH: 4200
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_02416 genomic DNA region
<400> SEQUENCE: 227
gaagaagaaa caggtgaaga ataatgtctt aaacatcatt ttagcaccct attctgccat 60
tctgtatctt tataggatat gtccagtcca gtcccagaaa atctactgcc caaggagttc 120
tagatgacag gttagatcaa gccccggcaa atgtttgcga aaacaacatt caactgcctc 180
tggacattgc aaagacatat tccagggagc tatctcttgg gctctttttt aacatctctc 240
ctagaggatg agactccttt cgggattaca gccactggga aagtaaaagc aacagtagca 300
tcaacaggtt gcatcgcact cccgcgcccc aggggcggtg caggagagcg cccggagcca 360
gagccagggc gcgctgggcg caagctgggg cgcgcccagg gccaatgagc ttctgattgg 420
ctctttgctg tgaatagact aggccgaggc taataggacc ggagggggcg ttcacctggg 480
aattggcctc ccccccttgc caaggacctc cctgattgta tggggcggag tggggtgggg 540
gtgggggctg gaaaggggaa gcccacccta actaaacgga ggggcgggag gaggttaaac 600
tgaggaagcc acgagcccgc agtaaagaga gggcgatcga ggcaaaaggg taggtaactt 660
gggacttctg tgccttgaaa gtgttaagga ttgcagggaa tgcaggcgcc tttcatttta 720
ctttgggcac cctcccctgg ctgggcattt aatgaggagt cctactgtgt gtgttgaaac 780
tctgcataat accgtaaaat attctggccc taaattacac tcaacggaga gatttaggca 840
gattacaatc ctaattggcc gcagggtgct ggggaaaggg gacagagaga attgggggat 900
ctggaatttg gtgtgctatc actacaccgc agctctattt tccattaaga aaaagatcat 960
atgacgaagt cgaactaaga gatctgaagt aaaaaatgaa aagatggagc aaaagtaaga 1020
aacatactct gagacgagtg ggttttcccc ctttattcca acagcaatct taaatgatgg 1080
acgtcatgta gcagttatat atctatgaac atgcatgaga gatttataaa tacctgcata 1140
cataaataca aacatcctat tatacatgag aaatcgtaaa tgcttgggca tcagaagtgg 1200
gagctgtgat cctagcttgg gggcagcaca gggtaggcgg ccttctctct gctttgagtg 1260
gcttctgggc gcctggcggg tccagaatcg cccagagccg cccgcggtcg tgcacatctg 1320
acccgagtca gcttgggcac cagccgagag ccggctccgc accgctcccg caccccagcc 1380
gccggggtgg tgacacacac cggagtcgaa ttacagccct gcaattaaca tatgaatctg 1440
acgaatttaa aagaaggaaa aaaaaaaaaa aacctgagca ggcttgggag tcctctgcac 1500
acaagaactt ttctcggggt gtaaaaactc tttgattggc tgctcgcacg cgcctgcccg 1560
cgccctccat tggctgagaa gacacgcgac cggcgcgagg agggggttgg gagaggagcg 1620
gggggagact gagtggcgcg tgccgctttt taaaggggcg cagcgccttc agcaaccgga 1680
gaagcatagt tgcacgcgac ctggtgtgtg atctccgagt gggtggggga gggtcgagga 1740
gggaaaaaaa aataagacgt tgcagaagag acccggaaag ggcctttttt ttggttgagc 1800
tggtgtccca gtgctgcctc cgatcctgag cctccgagcc tttgcagtgc aatgtcccgc 1860
ctgctgcatg cagaagagtg ggctgaagtg aaggagttgg gagaccacca tcgccagccc 1920
cagccgcatc atctcccgca accgccgccg ccgccgcagc cacctgcaac tttgcaggcg 1980
agagagcatc ccgtctaccc gcctgagctg tccctcctgg acagcaccga cccacgcgcc 2040
tggctggctc ccactttgca gggcatctgc acggcacgcg ccgcccagta tttgctacat 2100
tccccggagc tgggtgcctc agaggccgct gcgccccggg acgaggtgga cggccggggg 2160
gagctggtaa ggaggagcag cggcggtgcc agcagcagca agagccccgg gccggtgaaa 2220
gtgcgggaac agctgtgcaa gctgaaaggc ggggtggtgg tagacgagct gggctgcagc 2280
cgccaacggg ccccttccag caaacaggtg aatggggtgc agaagcagag acggctagca 2340
gccaacgcca gggagcggcg caggatgcat gggctgaacc acgccttcga ccagctgcgc 2400
aatgttatcc cgtcgttcaa caacgacaag aagctgtcca aatatgagac cctgcagatg 2460
gcccaaatct acatcaacgc cttgtccgag ctgctacaaa cgcccagcgg aggggaacag 2520
ccaccgccgc ctccagcctc ctgcaaaagc gaccaccacc accttcgcac cgcggcctcc 2580
tatgaagggg gcgcgggcaa cgcgaccgca gctggggctc agcaggcttc cggagggagc 2640
cagcggccga ccccgcccgg gagttgccgg actcgcttct cagccccagc ttctgcggga 2700
gggtactcgg tgcagctgga cgctctgcac ttctcgactt tcgaggacag cgccctgaca 2760
gcgatgatgg cgcaaaagaa tttgtctcct tctctccccg ggagcatctt gcagccagtg 2820
caggaggaaa acagcaaaac ttcgcctcgg tcccacagaa gcgacgggga attttccccc 2880
cattcccatt acagtgactc ggatgaggca agttaggaag gtgacagaag cctgaaaact 2940
gagacagaaa caaaactgcc ctttcccagt gcgcgggaag ccccgcggtt aaagatcccc 3000
gcacccttta atttttgctc tgcgatggtc gttgtttagc aacgacttgg cttcagatgg 3060
cagctacatt tgatggtttg caaatgccgc cgctgttcca aacttcctac ggtccatatt 3120
gtttgatgaa aactttctgt taaaattgtg tcctttccgc ccaccttctg ctcccccttt 3180
agatagatac ggtataattg taggtacccg tatatggcat cattattcta gttccctgct 3240
gccaatacgc tgctaaaacg tcgcatcttc tctgtcactg gtttgggttt aatttatttt 3300
acgccctggg catccatcct tgtgtgttgc gcactcaagt gtgggagatt tagtcttccg 3360
aagttgtttt ccaaaatgca caatgaaacg caaaattagt gcttccaaag tggataactt 3420
ttgactatgg aattgttaga aaacaagaaa ctttaaggtt tatatattgt ataaacatac 3480
ccagtatgtg catccgatcg cgagaacgtt ggcgtctttt aggaaactcc gcgcacgcac 3540
tttatcagcc gctgctgcgg tggtggctcc aggagaaact caactgccaa ttgcagacca 3600
gttttttttt ttttaaacac agccacttat aattcttaag ctctttgcaa atgtttgttt 3660
aaaaaatgaa aaattaaaaa aaatctagta gtgtcaaacg catttggtca attttatttt 3720
gctttgttaa tattagaaaa cttatttatt attgtttgct accatttcta cttatcttga 3780
ttcatttttt acgttttcta ctcgagatca ttttatttta atttagcaaa gccaactgcc 3840
cttgtttaat gtattttgtt ttgcaaatga ttaaaataaa tgtgaaaaga agccttttgt 3900
cacttattcc ttgagtataa ctactgaaaa caattttcaa atgaatgact ttgaagaatt 3960
gagttaagtc ttctattcaa tgtcatttat gcgatcttac agttttgaag aaaaatgttg 4020
taaacttggt gccttcaggt agtatcaaaa ccccttcaaa gaaaagcact caagtcaata 4080
attaaattgt gagataaaac ttcttccaaa tttgcagcac agttttgcct ctttgatggc 4140
caggatcttc ccagtcttct ttactccttg ccccaacaac atctgcaagg gggggaggcc 4200
<210> SEQ ID NO 228
<211> LENGTH: 6288
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_87540 genomic DNA region
<400> SEQUENCE: 228
aattcctcct ggggtgctgg gccggctctc tcccctcagc cctgggctct tacctctatg 60
agctggtagc cttgcttgca ggtagcaatg aagtagtcac ggaactggta ctgaggctgc 120
aggttctgga tgatggtgaa ctcgtctagg gtcttgggct gggggcactt gatgactgtt 180
ggggagacca gggggcatat ttatttcaga gccacttgtc cttccttctt cccccctttt 240
ccccattgct ggccatcgag ggaggcctgc agggagcctt actctcggtg gtgtagcgca 300
gcttccagcc ccggctgtcc cccgactcat ctgtgaagaa cagcagatcc acagcattgc 360
tgctggtgtc gaggtcgggg ggcctttgct tcccacagaa ctcgccaatg ttcttcccgt 420
tggcatagat ctagtagggg aggagggttt ttttttttca gcttggacgt ttttacacag 480
ggccaactgg gtagtagcct ggtggccagg gtggtggtgg tggtgatgaa atcctgcctt 540
atgtgtgttt tcaggggaag gtgaaaaggg atccccatga cccaattcta gttgtgtggg 600
aacttaccca gcccatgggt gatgttggcc gttcctgccc cagctggcca ggggatccag 660
gaggaagttg ggacaagagg agccaagtgc agacagaagg ggaggaaggg gtctttcagg 720
ggtaggacgg ctgtacctgt agctggtcat aggggcagtg tacttgctgg tggtcatcaa 780
tatcaaaagg ctccaggaac ttgaggtgca gggtgaggcc ccgctccacc cggatgctgt 840
agttgcagcg caggtcaggg gggtaggacc gagggtactc caggctggag atgtagcctg 900
atgcctccgt gtacagctcg ctgctgcact cagctgtgag agcagagcca cagggcatta 960
cgggggactc cagctggccc agcaagccct ggctcaaccc cttcccctct gctacaccac 1020
tctggctcac cctggcagga atgcgtgtct tcctgaagct catagcctgg acggcaggaa 1080
cagaagtagc ctccaacgta gttgtgacac aggtgctggc actggggctg gggatcctcc 1140
tcccctgatt tgctccggga agcacattca tcaaggtctg gaaggcattc aggaaggagg 1200
gttaagcttc tgctgggaga cctgagtagt ggctctgatc ttagggaggt cactcaccag 1260
agacctaaag acaaaggcat ctttaggcca cctggacctc caggcctctc caatgctctc 1320
tggggactgc tccatgggga cagagcccag gttgacaggc ctcgttagga aaagctctct 1380
cgaggggagg aacaaggaaa gccaggcttt cggcttcttt gcattcaaga ttccctttct 1440
tggcccccca ttcaatatgg ctgaggtcag agaaaaggga tccctggggg gctactcacc 1500
cacagcttgg tagtaggcca ggaagccctt gtagaacatg atggtcccat tctcctcgtt 1560
ggagaagtct gtgtggaagg tcagcagcat cttgttccct tgggacataa attccttctt 1620
tcccgggggg ttgcccagtg gagaacccag ttgcccacag aacctcccca ggcttttctt 1680
atcagcagag atctggtgga agaaggacag tgggtaggaa gaagatctgt tgcggagtgg 1740
cgcacgtggt ggctcagtga tggtcctcct tgtctcgccc agagtgcatc atgcaccgca 1800
atggctctgg ctggtcacta cctgctgggc tcagctgctg caaacttccc catgtgactt 1860
tcagctgttc cctgagtctc ccactgattc actctttgcg tgttgtcctg gactgggtac 1920
ctcacccttt ccctgttttc tgctcctctg gcaggtttca ggtccttctc catccccacc 1980
acctcctatg gcctgttccc ctggggtcct ggttgtctgt acccagcctt tacctgcccc 2040
tcattcccag agctcagaca gctccgcttt attttctgtc ttcagattcc acctcagcct 2100
aatcaaacca ttcacacctc gagtgcctcc tgatgccctc ggcggaacat gagccctgaa 2160
gcccacccat ctcagtgtca gcaggcactg cctcgtccct cttccttcct cctcacagcc 2220
tcctcaacct ctccttgact ctgccagcaa acgccctccc ccaacactgc acactcgcca 2280
agtcttctga gccggtaaga cgtgccattg tcatgtaatt cacgcataat ctccaggggt 2340
ctcctgggaa tggtagttgt tggaccttcg caggctctgc ttgagccctg aatctcattt 2400
ttactggata gagaaagaca ggcctgggaa ggtacccttg gttgccacag aggtgagggt 2460
tctgagcaca ctgtccttgc tgaaggctat tcctgtgctg ccagagccca catttctcct 2520
cctcatgtcc ctgtgttcct gttgaagcag gcagccatgt caatcatttc cttggagaca 2580
gggaagctga ggcacagtgg tttcccaaag actctcagct agacagcaga tggggaaggt 2640
tttcctgact cagtggatgt tgaatttcct gagtgggtcc tgtccccttc cttctctgtg 2700
cttctcccct cagtgctcac cgagggcctc tacaccagtg agcgcccatc cagggcatcc 2760
ccgggctctc agagaggccg ttggccatca gctcttgtgg ggctgggctg tgtctggggg 2820
tgtgcatgcc atacagatcc cagatcccag agggcccagt tttgtctccc ctctgcccgc 2880
ccatcctgcc cctaccttga cataatcata gaagcagcct tcagaaggct ccaggtcaaa 2940
ctgctggaag acgagcttca ccctgtatcc cgtggggact gtgatcacag tggttgtttc 3000
aaagttgttg gggtaaggct tggggaacag aggggaagtc acctccccaa ataacttctg 3060
agggatggga atggagcctc ctgccctgca gaacagggcc ggcaccagga ggtacaagag 3120
ccacctgcca aaacaaaaga gagtatctgg agctggaggg gttcagcact cttgccatgt 3180
gggcagtggc tgtggcaggg gatgagacgg ccataccact gggcattctc ctctctgccc 3240
accctgaacc tcacagacat gttctcagca ggggtgcgtg ggtggggagg atggcctgtg 3300
cagctgctgc atcgggtcac tctccagggc agtgtccagt ccagaggcca ccacactccc 3360
ctcacactcc ctttccagcc tcctcccctg cccggacgcg tccctcccct ccccttccag 3420
gaataggact ggcttgggac cagttaatgg agggtgaggg tttccacccg tgggtctctg 3480
aaagggctcc cacaggttca gcaagagcgt ctgggagaaa ccatctgtgg agtgggggac 3540
acaggcacag agtgtcccgt cctgggcaag gggtcccctc ctctcgctgc tccctgccaa 3600
gagcccagag ggaagaaagg accatggcat gagcatctat gtatgaagtc tcctctgatc 3660
cctaggagga gggatggggc gtgtgttgtg tgtgtccacg cgtgtgcaca gtggaactga 3720
tgaggtgtgt gaagagagaa gggtgttcct gtctccctga attgcctccc atgccctggc 3780
ttctcccctg gcttctccct cccacctggt tgcccatcac ccttactcac atttctcaag 3840
gcccgtgttg aatcctgggc tctcccgaca gcgtcttcgt gcactgtgtg cagagggagc 3900
ccgcgtcatg cacagcaggg aggggagggt tttctgtgga gtggaggggg gaccattccc 3960
ggaggaatgt tggagggaat gaactatttg cataaacaaa agatctgagt ttccacttta 4020
atttagtttt ggttttgaaa tccctgtttg tggtgccacc tgctggtcgg tgagggaaag 4080
ggctaaggag acgggagtct ggctttttag ggcccgggga gccttgggtt ggaggcccag 4140
atgtctcagt ctctaaatct gatcagcttc tcccttcttc caagactttc ctgggggctg 4200
ctgctgtgtt tacaaggttc ctaccaaagc agtgggagac cacaggtggt ggtgaattct 4260
cttttctggg ctgtcctttc ccattgaccc tgttcttcct gccctcattc agcccacagc 4320
cctggtccaa gaatggcccg ggtttcaatg cccaggacgt aatgatagga acactggggc 4380
agaggagggt gtgtgggagc gggcagagga gagaggagct tggttgcctt ggggccctgg 4440
cctgctttag ccatgaatga cacttggaca tagaataggg ttggccatgt cagggcaacc 4500
ctaaatcagc cctgggtttg agaccctctg gggcggctgc ggagggggta aaatgtcccc 4560
atctccttag catctgctca acacaactgc cagggctgaa gctaaggatg cgggtgtgga 4620
gcaagaggga ctcggttttt ctgagatgaa gccaggcccc tgggagggag gagggaccct 4680
agtctctcct gtccatcagg ccatagtgtc ctgctttaaa acttttgctc ttggccacgt 4740
gtggtggctc atgcctgtga tgccagcact tttcgaggcc agggtgggaa gatctcttga 4800
gcccaggagt tcgaaaccag cctgggcaac atagtgagat ctcgtctcta aaagttaaaa 4860
taaattaaaa aacaatttca ttgtttttgg aaggctttct tcatcaactc tccatggcac 4920
caaatatctg atggcacttc atcccacgga ggggcttggg ctgcagagca ggactctgcg 4980
ttcttaagcc tttgtaggct gttctgcttg tttcccttat tagatgaatc cctccaacct 5040
ccacccttct gcccccaccc ccgttcatcc atttatgggc tacctgttta atgtgcaaga 5100
cactttccca ggcaatagat tgcaagaatt cacagagctg atgcagttcc ccatcaggca 5160
gtgaccacat catcagtagt tagacagcag gcacacagaa ggtgcaagat ccaccaacgc 5220
ttggagggtt tctccagcag gcctgtgtgt cagagctgag gactgaacct aacggagggc 5280
tggtctgtga tgggatcagc atatgatcca cagccttgtt agatcaggaa agacaaaaga 5340
tgggggagaa ggaaaagcac cagatcagag gacgagaagg aaggggaatc tcgtctaaca 5400
aactgcacat taatatccta gcagcagttt gtgtgtgtgt gtgtgtgtgc acgcgcgcat 5460
gtgccgtatg ttcataatgg aggcagaggg aacaggtaag gaggtaagtc ttagctgaag 5520
ctcttccgtc catcctaggg attctcagtt ctgcattggc attgtgcaac acgcttggag 5580
agcggcaaac ctggatgtca ttagctcagt cccagccctg tctccactct gcccaaccat 5640
tcaaaataac ctttactcac acatttttgt tatgtccttg actttgtttt gtccttgact 5700
cataccaaga aggaaaaaaa tgccatatga aatgctgctg catttgtttt aaaacaatta 5760
ttgaggatat agtcggttac agtgtttgtt cctttaagga tttgattctt gggaaaaaga 5820
tttctctctt aaagtagtgg taggttttcc tctgtggata tgtctctatc gctagctcat 5880
ctatctccat caagtctatc tcttacctcc ctctctctct cattgtcgat atctctatct 5940
ctagacagag acagcgatgg agatgtagag atatagatct agacatacac atataaatat 6000
aggtatatat atatattttt tgccttggca gggagaaact catatcattt tttgcaatca 6060
taaaaataag caaaataaaa taaaaacatt tcatgctcat taaacaaatt ttagccaata 6120
gagaatagtg gaaaaccaaa cagccaaaat cttatcaata aaaccacctc tgtttagtat 6180
tttgagagaa ttattattat atttttggag atggggtttc actatgttgc ttaggctgga 6240
cttcaactcc tgggctcaag cgatcctctt gcatcagcct cctgagtg 6288
<210> SEQ ID NO 229
<211> LENGTH: 2800
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_110107 genomic DNA region
<400> SEQUENCE: 229
tataccctga tcagggtggg ggtcatggtg gtcatctaga cattctatgg ctgggtggtg 60
gtggagggca ctcaccttgt gaacactcgg acatggtgaa ttggcattgg cattgctgtt 120
gaaggacaac tcagccgtgt tcttagccat ggccatttag gcctgttctg atgcagggtt 180
ctgatccaag gtaccagtgt ggtccctcag ggaagtactg gggatcgtca cttatgcctg 240
ttctggacat ggtcaccgag aactgtcctg taggcattca cttaggaatc attcgaagtg 300
gaattgctcc tggatacgtt ctccttgtac tctgtttcct cctcctagtg tctctgtgtg 360
aagaagccct cctcactcag ccctcggcga ccctctggta ccctggacag ctccccgggg 420
agcagtctac cgctaggcgg cggctgctaa gagaggaacc ctcctgacgc ggagtctgcc 480
gctccggggc tcgctctccg gcaggcccgg ggagaggtgg ggtgacaatg ggttggggtg 540
cgcgcgtgcc tcataggtgc gagacagagc gagccgccgg ggtgtgagtc agcgcgctgg 600
gggctaagaa gctgggtgaa tagtcacgga atctcactca cgctcggctc ctccacccat 660
cccgtctaca gcgcgtgtcc cagtccaggg cgtgcgtgcg ctcggtgtcc gattccgggc 720
tgtgtgtgtc catttggcga gatgtcgaga gcggggggag tgtccttgtc ggtgtatctg 780
ggcccaggtt aggggacttc tcctccccac ccccgcgtgg gtgtgggggt gtgtccgggc 840
tagggcgcgt gtgcttctgt gcctgtgcgt gcgtgtgcgg gtcagggtgg tgggaccgcg 900
catcagggca gggtgcctgc gtctgcgtct gggtctgtct ggtctgcatg tcggcgcgat 960
ctcgacctgg attcgtgtcc ctggatgtcg agaggccagc gtggtggggg tgtccagcct 1020
cccggaggag tactatgcct tgacaccttc gtttcaccgc cccaaagctg gcctggggct 1080
ccgtagggag tggcctgcat ggggagggcc cgcgtgctgt gtttctggga ggggtaagag 1140
agtgggggcg cagggggcgg gccaggtccc tgggcgcggc gcgggctcgg gggacccgcg 1200
cggctgacgt caggccactc cttaaataga gccggcagcg cgctccgctc ggcatttccc 1260
gaagagccag atcgcggccg gcgccagcgc caccgtccgg tccacccgcc agcccgcaca 1320
gccgcgccgc cgccgagcgt ttcgtgagcg gcgctccgag gatcaggaat ggggcttcgg 1380
gcgctgggcg cgctccgaac ccggcgcacg taagagcctg ggagcgcccg agccgcccgg 1440
ctgcccggag ccccatcgcc taggaccggg agatgctgga aatgcaaccg cctgttcccc 1500
gaggagccgc tgcccccggg accccctggc actgtgcgca ccctggtcag cagcccccgg 1560
agaagacggc gcccccaacg cccgacccgc gtggccgtgg cagcgccacg cgagccctct 1620
aggcgaccgc agggccacag cagctcagcc gccggtgccc cctcggaaac catgaccccc 1680
ggcgcgggcc catggagcca tggcctatag ggtcctgggc cgcgcggggc cacctcagcc 1740
gcggagggcg cgcaggctgc tcttcgcctt cacgctctcg ctctcctgca cttacctgtg 1800
ttacagcttc ctgtgctgct gcgacgacct gggtcggagc cgcctcctcg gcgcgcctcg 1860
ctgcctccgc ggccccagcg cgggcggcca gaaacttctc cagaagtccc gcccctgtga 1920
tccctccggg ccgacgccca gcgagcccag cgctcccagc gcgcccgccg ccgccgtgcc 1980
cgcccctcgc ctctccggtt ccaaccactc cggctcaccc aagctgggta ccaagcggtt 2040
gccccaagcc ctcattgtgg gcgtgaagaa ggggggcacc cgggccgtgc tggagtttat 2100
ccgagtacac ccggacgtgc gggccttggg cacggaaccc cacttctttg acaggaacta 2160
cggccgcggg ctggattggt acaggtaagg accaggagct ccgctccgtg cgccgggtct 2220
ctgatcgctt ccattgggag agccatccgt ctcttgtgtt ttctctttct tttaacccaa 2280
ctcattgtat gggttcaggc tgacacacag ggccatgggg ggctatagca gaatttaccc 2340
agaacttccc agtgataatc tagacgggca gtttctggaa ctgcaaaggg cgttccctcg 2400
tcactggagt cgttggaaaa ggattatctc cagtcaaacc taagtgccag ctaaagggct 2460
aactccctct gtgaccagcc cttagggtgc ccaaggaagg gacaggcgag gacctgtgct 2520
gcctgaacac ggcaccatcc taaccctctg taggtctttg ctggtaccca gcccctgaag 2580
gaccctgaga aagataaggc agttcagaga ccccttgcag caaggctctg tttgggaaag 2640
gtccccagag ttcaggccaa atgacagtgc atcgccagag gtctccagta agaaagatgc 2700
cttagggagt ctcaatctca aacccaggta tttgctgctg tactggggct gagaccccca 2760
gtagctctgg ccctggtagg tggtctttga gtagtggaaa 2800
<210> SEQ ID NO 230
<211> LENGTH: 2500
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_89799 genomic DNA region
<400> SEQUENCE: 230
tctctagaac ttctggagaa aaaagtaata aagctaccag gttaaatgac tgaaattcct 60
gagagaaaac aacatgtgtg tgtttctcta gaaagggggc ccaatactga ataccaggaa 120
gtcctatagt aaatggaatg tgactctatg tgggatccgg cgttcctatt tcatccgaat 180
gcatgtctgc tgcttcagtg ggaagggtgc ttgcacacca ggtacccact ccctggtgtc 240
atgtgctatg cagtccaaag acagaaccag gaatggtgag cccatgagcc tgctggaccc 300
agcccctccg aggtccggag tgacaaccag tgccgtattt ctagatcaaa cctgaacccc 360
tcctacaggg aaaagatttc caggggattt tgaaagttcc aacattttac agggaagaag 420
gaagataagc aggatatgaa agaagagttc atgttataca gccctggctt ccactgacgc 480
taacactgga ttcagctttt gacactgata atctgttgcc accaaatgga aaacgtaaac 540
aagatattct aagtgtggtt agagaatatg caacacaagg aacaagcaga acattcttct 600
ctggaatctg acataatgga ctgtactttc acagacagca ctgatgttag atgtacgtga 660
aataggctaa actgaaaata agaaaggctg aggcagagag gataatatag ctccagccta 720
tctcccagca ccttgttaat ttctctcaat ctccagccac aaatccgaga cacaacgctc 780
ttcctccaaa gaggtcgcgc cttctctgtg gtggttctca gggatccgcc ccagctcctt 840
ctccgttccc agccccacac actgggatca ccaggcaccc aagatcccac ctctcaggtg 900
gtatcttcag cgcaggctgc cactcagccc ccctccaggg atctggggca gaaggcgaat 960
atcccagagt ctcagagtcc acaggagtta ctctgaaggg cgaggcgcgg gctgcatcag 1020
tggaccccca caccccaccc gcaccccaag cgctccaccc tgggggcggg gccgtcgcct 1080
tccttccgga ctcgggatcg atctggaact ccgggaattt ccctggcccg ggggctccgg 1140
gctttccagc cccaaccatg cataaaaggg gttcgcggat ctcggagagc cacagagccc 1200
gggccgcagg cacctcctcg ccagctcttc cgctcctctc acagccgcca gacccgcctg 1260
ctgagcccca tggcccgcgc tgctctctcc gccgccccca gcaatccccg gctcctgcga 1320
gtggcactgc tgctcctgct cctggtagcc gctggccggc gcgcagcagg tgggtaccgg 1380
cgccctgggg tccccgggcc ggacgcggct ggggtaggca cccagcgccg acagcctcgc 1440
tcagtcagtg agtctcttct tccctaggag cgtccgtggc cactgaactg cgctgccagt 1500
gcttgcagac cctgcaggga attcacccca agaacatcca aagtgtgaac gtgaagtccc 1560
ccggacccca ctgcgcccaa accgaagtca tgtaagtccc gccccgcgct gcctctgcca 1620
ccgccggggt cccagaccct cctgctgccc caaccctgtc cccagcccga cctcctgcct 1680
cacgagattc ccttccctct gcagagccac actcaagaat gggcggaaag cttgcctcaa 1740
tcctgcatcc cccatagtta agaaaatcat cgaaaagatg ctgaacaggt gagttatggt 1800
ttccatgtac acaggcgact ggagccgttg gtcagaaata ctggcatgtg ccccctaaaa 1860
ataaaatcag gaaaacccag gggttagttg aaggactaga aattgggatt attgttttca 1920
caattaaggt ttcctttacg ataattactg ctctggtgcc agaggatatt cccaatgcct 1980
ggcgtcccca ccctggttct tccttcgttc caatgaatgt aggtaaaact gccttcattt 2040
gaggcccagt aggacaaaca gcaacaggtt ctggctgttt ttaatccaat agtacagtgg 2100
agaccaccgc cccaccccac ccccattcct aaaagagcat cccaagctta gaggtccctg 2160
ccacacagca cagctgtcat aggcagtagc cacttggttg ccaggctggg gaaactgcat 2220
tcggaaaact ctagaggctg gaggagcagg gcaggagaag agtgttgtgc aatcagcttt 2280
cccgagcacc tactcagggc acccattttc tcattgcagt gacaaatcca actgaccaga 2340
agggaggagg aagctcactg gtggctgttc ctgaaggagg ccctgccctt ataggaacag 2400
aagaggaaag agagacacag ctgcagaggc cacctggatt gtgcctaatg tgtttgagca 2460
tcgcttagga gaagtcttct atttatttat ttattcatta 2500
<210> SEQ ID NO 231
<211> LENGTH: 2200
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_45173 genomic DNA region
<400> SEQUENCE: 231
tgttctgaaa catccggtgt catccaagtc caaaattgga cagctttttt ttcagttctt 60
cctgtaacat ttggcagtgt tggccactct ctgcttcttt ggcaagaatc tcagaaaaca 120
ctaataactg ctccaggcag gagcctggaa gaggttacca agctagagaa ggaagcaaca 180
gcatagcttg ctaagggcaa acagcccaga ggaaacccac ggctctggtc aatcctgttg 240
ttgattgcta gatccagaga ctgttgtaga cctcccagtt acagtgaggt atctgacaac 300
ccctcacaag gttcttgaag ctccgtggtg gagggtatct tggataaatc cacagagaca 360
cattcaagag taaattctcc actgttggag acctcactca ctctgtttgg tctccaccaa 420
agacacggtt tttaattcat ggagctgcac tacaacagct caagaactcc cagccaaagt 480
tttagttttt ctaggaacat aaacgagcca atagtgtgga aatcggtgat taaaaacaaa 540
cctcgcacat tttaagacag aattattaca agtagcatgt acaaaaggaa aataatagcc 600
tacatttagt tcttctaagc ttcattccac aagagattga aatcgaagta ttctgggctg 660
gcacacgata gctggaacat catattttat tctagaaaca catttgcctt ggcaaagaag 720
agcgtgccta gaggagtggt caggatagtg agggatctgt gatccttcgt tctgaatcta 780
gaaaagtcac tggatatgcc cctcccccgc cccccaacac ggtcttatgt tctgaatgta 840
gaagtcactg gatgtgctga cacacacaca cacacacaca cacacacaca cacacacaca 900
cacacacaca cacagagtct gtggcctctt tcccaggcat tccaagtcca gcaagttcgc 960
agggagctgt cagtccgtcc aggaaggccc gggcctgggt ttgcctcttc aagcagctac 1020
tgcaggggcg tggggagggg gcataagaga ctttggactt tcctttgaga cagtagaaag 1080
cgttacatcc agaggcgaga ttctagcctg gggtccccgc cttcccggcc tcctcttcct 1140
ctccctctga ctccctttcc tgtgcccctc cccctgcctc tttcccggcc agagtccagc 1200
cttaacccgg gcagagggcg gagtcccgtt aagggggtgt ggggaggagg cggggccagg 1260
gcaggggcgg ggcagagccg ggccaagctg ggcgggtcat gcgccctggc cttcgcgcat 1320
ctcccaggtt agctgcgtgt ccgggtgcta ggctgcagac ccgccgccat gacgctgcgc 1380
gcggccgtct tcgaccttga cggggtgctg gcgctgccag cggtgttcgg cgtcctcggc 1440
cgcacggagg aggccctggc gctgcccagg taagggggcc cagcgccgcc gccgcagtgg 1500
gtcggggcct caggaggcag accgcgctgg gcttgcagcc cagctttcag attgctcctg 1560
tgccggagcc ctgcgaatca tgcgaatcat gaaactgaag acctggccct gaagtcccag 1620
tgcatatgag gagatccgtt gtctttctaa atgttcataa ttaaacgttg ccaaggtctc 1680
caaaattgct ttctgtgaac ttttccaaaa gggagaggag ttactcatgg agctttgtgc 1740
ttctgctgcc tcctgtctaa tggggtggcg cttaaagatg cgagccgaga ttcaggagag 1800
aagaaagttc tctccccagg tgtgggttgc atgcttactt gtgtaatagc aaactgcagc 1860
aaccgcccaa agccacatca ctgggaaatg gtagatgggg tgtgcagagt gagagctcag 1920
ggacttggga aaacacctgt tctactacat gaaaaaacca ccccaccaga atctgaagct 1980
atttatacaa tatggtttca gctatggaaa aaaggtacat gcagaaaagt gcctgaaaga 2040
aataggccaa agtacatcaa atgagattag gaataatgta atgattttct ttctctctct 2100
cttttttttg tgtttttttt ttttgtagtt tccaacttct aaatttataa acaatgtatt 2160
attcccacat tcagaaagga gagaagtata cttatttata 2200
<210> SEQ ID NO 232
<211> LENGTH: 8800
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_80771 genomic DNA region
<400> SEQUENCE: 232
tcaaaaacta ctaagaattt taagagggca atggcagagc attaaaccag gcatcagccc 60
tttccttttt tttaattttt aaaatattta tttagatttt ctttttgtta gtaattaaat 120
ctttcttctt cttcttcttc tcctcctcct ccttctcctt cctctccttc ctcttcctct 180
tcttcttctt ccctcttccc tctctcctcc tcctcgtcct cctcctcctt gaaacagtgc 240
agtggcacaa tctcagctca ctgcaacctc cactttccat gttcaagtga ttctcatgcc 300
tcagcctccc gagtagctgg gattacaggt atgtgtcacc atgcccagct aatttttgta 360
tttttagtag acactgggtt ttgccatgtt ggccaggctg gtctcaagtg atccgcccgc 420
ctcagcctcc caaagtgctg ggattacagg tgtaagccac cgcacctggc tctttttttg 480
ttttgttttg ttaagtataa aacctcacct ggaagcacca gccctttctg agtgtgcggg 540
cctgtgccac tgcgtgggtt gcacgtccat taagctggtc tacctgccat ccacttcctc 600
aacccaatgg cattctcctg tttcttagat atgtaccaac cggttttctg ttttatctta 660
gcatggctca ctactcctca ttagggtctc tcagcgaagg gggtagcctt tttttttttt 720
tttttttttt ttgagacaga gtcttgctct gctgcccagg ctggagtgca gtggccagat 780
ctccactcac tgcaatctct ttggttcaag cattctcctg cctcagcctc ccaagtagct 840
gggattactg gcccacgccc ggctaatttt tgtattttta gtagagatgg ggtttcacca 900
tgttggccag gctggtctcg gactcctgac ctcaggtgat ccacccgcca ccactccagc 960
ctgggcaaca gagtctgaga ctccgtctca aaaaaaaaaa aaaaaaaaaa aaaaaagtca 1020
tactggcata gagtgaaccc ctaatccaat atgactggta tccttataaa aatacttttt 1080
ttttggagac ggagtctctc tctgtcgccc caggctggag tgcagtggcg cgatctcgac 1140
tcactgcaac caaaaggaga cattttgaca tggagacata tacagggaat atgccctgtg 1200
aacatgaaga tggccatatg caagcccagg agagaagcct ggaagagacc gtttcctcac 1260
agcgctcaga aggaaagaac cctgccaaca tcttgctttc agatgccccc aggattgtca 1320
gacaataaga tctgttattg acgccaccgg gttggtgata cttaggtaca gcagccctag 1380
caaacgaata cacccccatg agaactaagc tccctgagag cggtaagctg ccttgtcttg 1440
ctcacagctg acaagaacac gcctgtacgg tcacttagca cctagtactg ccatttaacc 1500
gtttcactag tatgtatgaa ccggagagcc tgtcaaggga agagctgaat cttttatctt 1560
ttgtaacgac tacccagtga aagaaaccgc gggtatgcaa taaaaacctg ttgaatcgat 1620
taaaccattt cccttatttc cagatttttg cggaaagcgc cagtaggtga aatatgtgcg 1680
gactgatgag tcaaagctct tattccctgg actgcattaa tacccacgac gtgcttttcg 1740
ctctccagac aaagagaccg gtacttggca ggtccctcaa gtgggactca aaagaccgaa 1800
ccgagctgca gcctttcgct agcactggtc ctcgcccctt ttggcatctt ggtacttgta 1860
gttttgtcca ctctatcttt acccgaaaag ccagcgctga gaccacaact cccatcaccc 1920
tgcgagcacc agcgccttca gagcgcatcc tccgaggggc accagcgcca ttgaccaccc 1980
tgctggccga agggcccgcc ttcccgaggc caggcgctcc cgcgattggc cagccgcccc 2040
gcctctcatc ggagggcgcc aggtgaatga aaggggggcg tgtcggtgcg cggtgctccg 2100
tggctgcgct gctggaaccc gctggaaggt gagcgcgaag aagcgggttg gcgctgccgc 2160
tttcgttggt ttggggagga ttcctagcac ccgggaggct ggctggagat tggggttagc 2220
gggcagggtt gcccccactc agtcatcctc cttcggaccg cttggccctg gcaactcctg 2280
ggacctccgc cccgcgagcc cttctagcgt ggggaggggc aggcgcggcc gtggggcccc 2340
agcttccctg tcattgggtg tcctccgcgt cgtccagccg ggggtcgcgg cgccgactac 2400
ttccacggtg aatggtgccc aggcgtgggg ggctcggcca cactggagaa gtgccagcgg 2460
cagcgatggc cactttgtcc gcgggaggcc atgggagggg ctaggccttg gggtcccacc 2520
ctcgggggcc gtgccctgta gctggttctg gtggcctctc tgcaggtcgt ctgatgctgg 2580
acgggggagg gtctgtcttg cgagcagttt agatgcagtt gaccctgaaa ttcttcgtat 2640
ggaaatggaa acttctccag tgtccttctc ctccgatcca tgcctaaaag aaaggagtga 2700
cttccccaac ctgtcgcatc gtgtcctgga gggtttgagg aggccggtta gcatagtggt 2760
taaggatgtc aacccgggag tcagtcggat ctctgttcta ttactaactt ggtgatgtta 2820
tctgcatctt tgaatctcag ttcctcctct gaaaaagagg atgtagttag agtatctgtc 2880
gtactggatt attgtgaggt gaaaactaat gtgcttgtaa aagccaggca tggtggcgcg 2940
cacctgtagt ccctgctact cgggaagcta aggttgggag gatctcttga gcccaggagt 3000
tccaggctgc attgaggtag gatcgtgcac tccaacctgg gcaaccgagc aagaccgtgc 3060
cttttaaaaa ttttaattta aaaagtaaaa tgaatatgct tgtactttgt acagtgtttt 3120
ataaggaata gtgcttaata tttactaaaa ttgaggagca ggtttttgtt attctcaggt 3180
tggtgggact ggaggagtct tgtcagaaag ggtcggaggt ggaattcaag gctgcttttg 3240
gcctctgaac agagacagtt gtgtgatctg gctaggactc cctcaagggt atatgagagt 3300
ttgtattgca ggtagttgtg ttggcatctg ctgtctcctg gaggacaggc actatacttg 3360
gttcattttt ctattcctgg catcttcctt gtgtcaggca ttgtatgtag ccggtaaccg 3420
ttgaattgag ttggaaccgt gggatggttg ggaggttccc tgccagagtg cggataaatg 3480
tgcttctgag agcagtctgc cctaagagct gctcttctgg gataagtggt gatcctcagc 3540
acttcccggg gcagcagagc acttcaggca aatgggggtg atataaataa atatttacac 3600
aatatatacc aagtacagga ttggggaaaa ttttgaagaa aatactatac ggatagactt 3660
ttgcaacgtc aggaagtaga ataaaaataa ttgcaataga ataaaaaata atttcagtaa 3720
gaaagccaaa agaaattggt tttaggtgct atttctggaa aggaggcttt tccagtgaaa 3780
gacggaagtg ccctgggaag agcccctata gatcagacca tactacaagt taagaagtgt 3840
tgtgcgtact tacatattta tctacctggc ttaccaactc cttacccctc tgccctgcct 3900
cctttttttc ttagttaaca aagaaaaaag ccaaggcaga aggatcactt gagtccagga 3960
gttcaagacc attgagacca gccagggcaa catagtgaga ccccatctct acaaaaaaat 4020
gttttcagaa ttagctgagt gtggtgctgc atgcctgtag tcacagctac ttgggaggct 4080
gaggtaggag gattgcttga gcctgggagg tcgaggcggc agtgaactgt gatcatggac 4140
tgcactccag cctgggtaac aaagtaagac cccgtctcaa aagaaaagaa aagcaataca 4200
tgcacatagt aaaacattct atcagaaagg tttaaaatga aaggcgaaag tccctccaca 4260
cacttgtttt tttttttttt tttgagatgg agtctcgcac tatcgcccag gctggagtgc 4320
agtggcacaa tctctgctca ctgcagcctc cgcctccacc gcctcctggg ttcaagtgat 4380
tctcctgcct cagcctcccg agtagctggg attacaggtg cccgccacca tgcccagcta 4440
atttttttgt atttttagta gagacggggt ttcactacgt tggccaggct ggtctcgaac 4500
tcctgacccc aggtgatcta cccaccttgg cctcccaaag tgctgggatt acaagtgtga 4560
gccaccacac ccggccccaa gtggatttta aacttggttt atagtttatc tactaagcag 4620
ttaagaaatg aatattcctt ttttgcttaa caaatctatt ttgtccaaag cactctgcca 4680
gatactgtaa gggatataaa attgaataag acatggctca tgctttcaaa gggcttgtag 4740
ttcattgaca gagaagggcc aggacataaa taataaacag gagttaacca agggtagtgg 4800
aatcagtcag ttaggagtct cccagttgca tgaaatagaa aacccaactc agaggccagg 4860
tgtggtgtct cacacctgta accccagcac tttaggaggc tgaggggggc agatcacttg 4920
aggccaggag ttcgagacca gcctgggcaa catggcaaaa ccctgtctct accaaaagta 4980
caaaaaaaat tagcctggcg tgggggtggg tacctgtagt cccagctact cgggaggctg 5040
aggtaggatg attactttag ccagggaggc ggaggtcaga gtgggccgag atcacaccac 5100
tgcactgcag cctgggtgac agagtgagac cccatccccc atctcaaaaa ataataataa 5160
taatatttaa aaaagaaaac ccaactcaga ccagctaaac caaaaaggaa cttaattggc 5220
ttctggcact gcttgagttg gggctccaat gttgtcccca ggctccatca gcctgagctg 5280
ggctgtcatc tttgttaggc tgacttccct ggtggtatgg cagcaacatc cctcacatcc 5340
tgcatcccac agagcaaaga gtgctctttt ttgaaattcc agcaaatgtt tcattgcttt 5400
tcattggctc tgaaaactac atggccatct ccgagccaat cactgtggtc acagggtggg 5460
atgccttaat tttattagcc tacattatag cttacacacc tggtgcttga ggatggcacc 5520
agctttatgc aaagcatgtt ggccaagaat gggggaagga tgcttccatc aaagccgaaa 5580
aaaggcacta gaaccaaaag aatggggaat gcatgctggc tagcccaaga atccaccaaa 5640
tacttcagta taatgatgat aaagggagac cagtcttgtt cgtgaccagc ctgggtaaca 5700
cagtgaaacc ccatctctac taaaatacaa aaaattagct gggtgtggtg gcatacacct 5760
gtaatcccag ctacttggga ggctgaggca ggagaatcgc ttgaatatgg aaggcggagg 5820
ttgcagtgag ccgagatcgc gccattgcac tccagcctgg gcgagagagg gagaatctgt 5880
ctcaaaaaaa aaaaaagacc agtctcaaag ttttgaattg ggacactgga ggctgggtgt 5940
ggtggcttat gcttgtaatc tcaggacttt gaggggtgga ggcaggagga tcgcttgagg 6000
caaagagctt gagaccagcc taggaaacat accaagactg ccatctctac aaaaaaaaat 6060
ttttttttaa ttggccaggc gcagtggtat gcacctgtag tcctaggtct tgggaggctg 6120
aagcaggagg gttgcttgag cccaggagtt tgaaggtgta gtgagctatg atcacaccat 6180
ttgcactctg gcttgggcga cagacccaag acccttcctc taaaaaagaa aaccagtttc 6240
agattgatac actaaacact caagtataat tttttttttt ttttttgaga cagaatctca 6300
ctctgtcgcc caggctggag tgtagtggcg cagtctcagc tcactgcaac ctccgcctcc 6360
tgggttcaag caattctcct tcctcagcct cctgagtagc tgggactcag gtacccgcca 6420
ccacgcctgg ctaattttta gtagagatgg tagttttagt agagatgggg ttttgccatg 6480
ttggccaggc cggtctcaaa ctccagacct cagctgatct gcccgcctca gcctcccaaa 6540
gtgctaggat tacaggtgtg agccaccgtg cctggcctca agtataattc ttagatgtgg 6600
atattttcta tagtttgagc cttgaagaaa gtagaatgta gtacattaga gcattggctc 6660
tggaggccaa tagacctgat tttgagtccc agatctgtta caactgggtc atctcctacc 6720
ctcaatttcc ttatcagaac aagggagaca atattaatat ttacttacaa ggtttttata 6780
aaaattcatt gaaagaattc atgtaaaaca gtaagcactg tgctcacatg caattagcta 6840
tagttatttt tttccataaa ttaacccagt tggataacct cttattttta ttagatccaa 6900
agcagaccat attattatta ttattttgag acagaatctt gctctgtcac ccaggttgga 6960
gtgcagtggc acaatcttgt ttcacgcagc ttacatctcc tgggttcaag cgattctccc 7020
acctcagctt ccctagtagc tgggattaca ggcccggcta agttttgtat ttttagcaga 7080
gaaggggttt caccatgttg ggcaggctgg tctcaaactc ctgatttcaa gtaatctgcc 7140
tgccttgtcc tcccaaagtg ctgggaagcc catatcctaa agacactatt gcaccactgg 7200
ttttggaaaa gttgtttaaa atttttaaaa gaaatcttat tggccgggcg tggtggctca 7260
cgcctgtaat cccagcgctt tgggaggccg aggcgggcgg atcacgaggt cagaagatcc 7320
agaccatcct ggctaacacg gtgaaacccc gcctctacta aatatacaaa aaatttgccg 7380
ggcgtggtgg caggcacctg tagtcccagc tactcgggag gctgaggcag gaggatggcg 7440
tgaacccagg aggcggaggt tgcagtgagc cgagattgcg ccacttcact ccagcctggg 7500
caacagagca agacgctgac tcaaaaaaaa aaaaaaaaaa aaaaaaaaag aaatcttgtt 7560
tgtaaaggtt gggatttgtg aattaactta agaaaaatct tggcagagat acaggtttgc 7620
tctggagcag cagcagctgg cggagcaatg gagatgcaat cctattatgc caagcttttg 7680
ggggagctga atgaacagag aaagagggac tttttctgtg actgcagcat cattgtggaa 7740
gggcggatct tcaaggccca caggaacatt ttgtttgcta acagcggcta cttccgagcc 7800
ctgctcattc actatatcca ggacagcggg cggcatagca ccgcctcctt ggacattgtc 7860
acctctgatg ccttctccat catcttagat ttcctctatt ctgggaagtt ggatttgtgt 7920
ggggagaatg tgattgaagt gatgtcggct gccagctacc tgcagatgaa tgacgtggtg 7980
aacttctgca agacatacat taggtcatcc ctcgacattt gccgaaagat ggagaaggag 8040
gctgctgtgg ctgcagcagt ggcggcggca gcggcggcgg ctgcagcggc ggcagcagcg 8100
gcggctcatc aggttgacag tgaaagcccc agttcaggcc gggaggggac ctcctgtggt 8160
accaagagct tggtctcctc tccagccgag ggagaaaaga gcgtggagtg cctgagagag 8220
tccccttgcg gtgactgcgg agactgccac cccttggaac tggtggtgag agacagcctt 8280
ggcggtggct cggctgacag caacctctct actccaccca aacggataga gcccaaggtg 8340
gaatttgatg ctgatgaagt ggaggtggac gttggtgaac agctgcagca gtatgctgcc 8400
ccgctgaacc tggcccacgt ggaggaggcc ttgccaagcg gccaggcggt tgacttggct 8460
tacagcaact accacgtgaa gcagttcctg gaggcgctct tgcgcaacag cgctgccccg 8520
agcaaggatg atgcagacca tcacttttct aggagtttgg aaggaagacc agaaggtgca 8580
ggagtagcca tgagttccat gatggatgtc caggctgact ggtatggaga ggactcaggt 8640
gagctccctt agcattcatc agccctgcca gtgattgagt acacactgtc tgtgccttgt 8700
gttctcccat catcatgatc attatcacca tcatcattgt cactaccaac attatcagta 8760
ccatcatcac cagtaccatc atcattacca tcatcaccag 8800
<210> SEQ ID NO 233
<211> LENGTH: 2800
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_69407 genomic DNA region
<400> SEQUENCE: 233
cctcattcat gcataggtca cacttctcca aagttggtat ggcctgtctc cttggcatgt 60
tcccttgctt ctgcttgtcc agttaatcct ttctgacata ccatgcatct cagggtgaag 120
cggttgacat cagtaaactg tctccttctt ctagcttcat ctgctaattc cagtgcttgt 180
acaagaacaa tatcatcatt agaggagaaa atggtcagag gaggtgtatc tggatcaggg 240
aagttacgct gaagtggatc atagtggatg ccatcataaa taagcagaac ccttttggta 300
tatcctgcat cttccccaaa acgatcaatt cttactgtct gtgtatccac tacacatatt 360
tcacattggt aaaacttgga caaaatcgat atctctattg ctcctcccca agtgtcatcc 420
cttttgatcc agtcacagta ctcttgattt gtttttccca gtattgcctc actatagaag 480
tctggatcgc ttgctacaat ttgtgctatg aggcgtctca tctcaggggc acaagctgga 540
ttcaagactc ctccttcgac gacatagtac acactagtaa agaggcaaga gttgtctgct 600
gggaccacgg ttctggtaag cacaggcaaa gtttccctga cgtaactaga agcaccacgt 660
ttagtaaatg caggtgaact tctgggcctg gtttggtctt cttcaatgat cagcatgtca 720
cctgttaaaa ataaaacaaa tcccgatctg caaagaaatt acagaagaaa ccgagtgttc 780
tctagccaag tctgtaaatt acaaactgaa ggagttaaag cataaactgg ggttactaag 840
gagaatacag ttttgcaagt aagttaccag taagaatctt tgttcactga attttcataa 900
agatgaaaaa agaacaaaaa acacttgagg ttgcatccca atttagtgaa ggggtctgga 960
gtaaacaact tcaagcttac ctaaaaagat acatttcaaa aacaaaattt cctttcctta 1020
tacagtattt tacagaaggt gctcactaca gagtaggccg ctagggggtt ctccttctcc 1080
ggaaacttat ctactctaga gtgtttacaa catccttgat acagcaactg aaagctttta 1140
attataaaca ctgatgttca agttttgata tggcacagaa ataactgctg ctggttagaa 1200
attgaaagag ctttcagtgg gtgttttaaa agctaactcg aaaatgagta tgcctgtcaa 1260
acgaagtatc tacgaagggg actgcaaaaa tgaatcaaga aaaaaaaaat cctgcaccct 1320
tgagatctca tcggtgatat agggaaaaag agacataagg acagagaaaa taggccctac 1380
tttatatttt tgtggacgcc gagggaaaac aaaatgggat agtttcaaag ccgaccagaa 1440
agcggaatgg ggaagggggt cttcaaggct ttgggttccc tttcaaccct gtgtcaagac 1500
aaggagttgc tagacacttg ccctggcccc cgtcagcatt ctctgttctt tgatctatcc 1560
tcgcccctgg cctcaaagcc cccccgccga ctcacagcca ccttgccttg actggtgttt 1620
tgttctctct cacgcccctc tccatcctcc cgggactttc cctggcccca gccctgattc 1680
cttaccagat tggatgggca agtcttccag aatggtatcc ccattgctga gatccaggca 1740
ctcgggaggg tatccgacga ggattcgctg accgccgggg gcgatcccgg tgatggcggc 1800
aatttggccc tggagttccc gcacccgggt ccggctggac agcccctgca aaacatgggt 1860
gccgtccttg gccttgcagc ggagccgcca catcgtgtcg gtccggctgc ccacaggcca 1920
ggcacccgcg gggccagctt tggtcccggc agcctgttgg gagacgccgc cggggaaacc 1980
aggcgccggg tggactccaa aatggcgacc tttagcgggg ccaaacatcg cgagaagttg 2040
cgggtggttg cagttatcgc gacgcttcgg tgcggcttct gccttagtac cttagcaagc 2100
gcgaactctt ttaaagtgac aactgatttt tcccccaccc tcagaacgaa gatgtaaacc 2160
tccgtattcc taaaggacaa cgggtcttgc tacctataga gcgagtgagg tgccctccgc 2220
gtgggtagca tatatgctca agaaaagagg gcgggggaag gagttcctga atgaaggtct 2280
ggagattgga atgtgacctt gcacttagtg aggtcggaaa ttattaaatt ggggcttcca 2340
cactacaccc agactacacc aggagaaaca gaatcatagt tcacaacgca aacgaatgcc 2400
aggaatggtc agtgagtcaa aggaccagtc aaaaacaatc acacttgtga ctagactcgt 2460
ggctgcatta aacattgact cattggggtt ccaggggcca aaagactggc ctttctgcct 2520
ccctgggact gtgcttgaaa acgtctattt gccacttcag aaagcacagt atgaggtcag 2580
catctgggcc cagggcagct gcctcattca ggtggtggca gtgtaaggag gagtcgtgta 2640
acgcgtgtca tcagattcca gttcagttcc tgggcataca aatatgaaga cttcattcct 2700
gccttcattg taacaagtat tcattgcagt tgggagacag ggtggggtgt gagacacaca 2760
gccactgaat ttcaaagcaa cgtgataatg ctagattatc 2800
<210> SEQ ID NO 234
<211> LENGTH: 6900
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_05406 genomic DNA region
<400> SEQUENCE: 234
agatggaagc ccaccccgaa aacagctgtc attgtgggca catgttgtag agggggtgtg 60
ggggttacta ctttgcttta ctacaagtgg aaagcggggc tcaggagctg acaagtcgcc 120
agaatcatcc cccagacaca ccaggcccat caggtggaat tctgagctgg gctctggccg 180
agggaacagg cagaaaaccc ctcctgctgg ggacacttta tacctgccca gaccaggttt 240
ggcgtttggt actttttctt ttttgatcct ccatttattc ctgctgcaaa tccggccaga 300
gttatcctga ccagtgatct atgctcattg gattgagtca acatattaaa tcccagattg 360
attgttttac tgaagggcct tgacaaatag tgtccacaat gttggagcag gcccgagcct 420
ggcgtctcca ccaggtctgt cttggctcag cccttggcag agccctggcc agaagctgtt 480
ctctctggct ccgtcccact tttgggtctt cttgcagctg aacaggttca atcgcccagt 540
gcccaatccc acagaaagat ctgaagggcc tgggagttgc ctggaggtgt ttaatgcccc 600
gcaggctgac tttgttcagg taaaaccctt tgcaaaccac aacaaaagcg tcctgggaag 660
atacaggcct gatcagaggg agctcccccg agccgctgaa aggccaacac agccgcaaac 720
aatgcaggac aaggcgatct tatcaaagaa aagccctttc aatgccttaa taacaaccac 780
attctgtttg aattaccact actgagcaaa tggcggcccc ggctttcatc cccctccccg 840
ccaggcgcat taacataaac acgaccctgc aggcgcattt gaatggggct gcggccccga 900
ccccgcgcct gctatgaaag taaagggaac taacgcgact ttctccgcgg tggacgctcg 960
gacacgcgtg accgcctcaa acccactcca ggctgccatt ggtactcgcc cctttttaca 1020
gatgaggaaa tggagaatca gaccgggtca cgcagatagt atcaggcggg gttggcaccg 1080
gagcctggct ggagccacag aggacacctc cggagctgag gcgcagggca gttccctcag 1140
ccgaacaccc cgggagggag actcgcctgg aagtgtctcg gagcgaccct tgctcgggtg 1200
ctgccccttc agtgtcccgg acgtgccggg caacgcgatg accagaccct gagcgctctt 1260
cgacccatgc cccaagggcc ttggaggcgc cccacacccc ctgggaacct aggagcgggg 1320
ctatggaggg gagggatgag agggacttgt cagaattcat tattgactgc gaaagtcacc 1380
accctctttc cgggccctaa aagagacaat ggcagggctg ggaaggtgta tatcaaagca 1440
agccaggccg cgtccccccc tccaccccca caccttgaca gatgacgctc cgcagaggag 1500
cccggctccg gcccgcgggc tgcggccacc ccacattaac atcacaaggg cacccggcgc 1560
cgactgcggc cttgccacct cggcgcagga cttcacagcg gcctctcatc tgctgacccc 1620
gcggcctggg ctctggcggc ttccctcccg cccccttccc ggccctcacc ccgcggccgc 1680
tctcccggga cacgcaaagg tcttccttag ggcgtgcgcc acccccgcca accgcgcccc 1740
agacaggggc tgtagaaagt gggtctttgg gagccaggat ctgggagccc ctgctaggag 1800
aaaggcgcct cctctaggag aagggaccaa gccaaagctc tgaggctcac ccgaggctga 1860
tctgtggcct tctccccggt cggcggcatt cccaccagga ctctccctag catgtgcaca 1920
gtgacgcaga aaccgatgcc cagagacagc ccccaaaggg cgctttgatt tatacagttg 1980
taattggcta taaacttctg caaagtgccc ataaccagcg tgcctgccca attggggcat 2040
caaggagcga agcaagaaaa gcggaagcgc tgagggctgg ggaaagactt taaaaggggc 2100
actcaactag gactctcccc accgcacttc cttgccacct ctaggcacac tcgaacacca 2160
gaaggggcag acccagagtc aatgagcccc acagtccggc aaacctagga tctttttcag 2220
ttgcacacac acactcacag acatccctga cacccttgaa aggaagcttt gggagaaatg 2280
acccctacct ggagcggcgg cttaattccc accagggttt cctccccgtc tccctgctct 2340
ctccgcagac gcctgcccct aggcttcttg cccctagcct tccagctttt gcttgaaatg 2400
accccttcac aggtcagagg ttcagagacg gggcgcgccc ccgtcgcctt agcagctggg 2460
gctagcacct tcttcccagc gacagcagct ctccctggtc tgcctgctcg ctgtaccttg 2520
aattggcccg agtggccaaa cccggtccca cacacagcct agccatcctc cgaccccccc 2580
aggtcacttc tcttcttaga tggctcagat ggggaaagag agagcggaga taaatggcct 2640
agacctagcc caagaaggtt cgagcctccc tctctcctcg gcggccagga gccacgcaag 2700
gaatgcatgc cgcagcaagt gccggaggac gcgattctgc cggcgtccag cagtgctcac 2760
gccgacattc cccggagctt cccgaaggtg tcccggggtt gcgaatgagg agctcttgga 2820
aagaggacgc ctgaacacgg tgttgagact cagaatattc actcccaggc tcagtaggtc 2880
agagaagccc cgacgggcca gaggcccccg aatttgtctc cgggccgtgc ccctcctggc 2940
gccgagctcc cagacagccc gggacgcccc tgtgcgcact ggacgcgcga cgcgcagcag 3000
ccactggctc gacccgcgcc ttcccaagca ccctccgaag gggcgcagcc tctgcttacc 3060
ttggctgccg agggactgct gcgccggctt ccgcatccac tcgcacaggt tccgccgctg 3120
gccgccggga gacagctgct cggcggcagc ggtggcggcg ggcccaggag ggccggggtt 3180
gagcgtttgc agcagcccag aagcgcagga aggcgcggcg gccgggtggt gcgggtggtg 3240
atgcgggtgg tggtgcggat ggtagtctgc ggggctgctg tagcccatgg ctgcggccgg 3300
ggagccaccg ttgaggccgt gagccacggc gttggcggcg gccgcggcgc ctccgggcgc 3360
gtagccattc cagtcctccc ggagtggggc gccatacgct gccggccagg atggccccgg 3420
ggactgcgcg ctgtccaagt tcgctgccgc tgcagctgcg gccgccacgt ggtaaccgcc 3480
gtagtccggg tactgcgggg ggctgacgaa gttctgcggc gccaggttga ggccgccaga 3540
gtggcgcacg gagctagggt acatgctcac gtccttgtcc aggaggtagc tcacgtacat 3600
ggtggcgagg gtccgggagc agacctcacc atgctgcctg gggaccgacg ctggaggctg 3660
ccggggggca cgaagggaaa ggggcgaggg gactcgagga gcggcgggtg gctgcgcccc 3720
agcccgcggt gctccgctgg ctcctcgcgg ctcttctgcc tccgaggcgg tccctccctc 3780
tggcctgcct cctccctccc tccctttctt ccttctttcc tcccacctcc ttcccactag 3840
gctgcagagg cggggaagac ccgccacagg ctggcgtgcg gagccccagg ccggcggcct 3900
tccgtgatta acgagtgttt acaagactct attagtaatg acacagacac caatggttgg 3960
agacgtcgag gcgcagcgcg cactctacgc acaacccctc gaaacataat ttgcatttta 4020
aaagataaag gggagggagg ctcgtgagag ggcagcgacc tgacacagct aaatattcaa 4080
acctttattg ttaagagctt cctccttcca acctggtgca ctttaacctc caatcacagg 4140
ttcaaagaat gaaatcaaga gacttacaaa agagagggga agagaaaagg ctatcttggt 4200
aggaatctga gcttggagac aggagcagtg gttgtttatg catttgcagg gaagagggcg 4260
gtcaagaaac tccttctgtc ccaaagagaa aagaaaagag aaccattgct ttgatgagaa 4320
cgtttctgac caacctggta ggtgacaagc agagagccct aagagatggg ccattccttc 4380
ccgccctgtg ctcctggccc ggacgactgc agccccaaac aactgtcacc tccagttatt 4440
ttcttgccca aggaaattac tcgccctccg cacaagacaa attatgatcc tagattcagg 4500
ctgcatctct gacttcatct tacatttgaa atttgagtta aattcaagcg atttattgtt 4560
aaacgtttac attcaagaat cagaagtttt aaactacaga agtaatgggc atgtggtaga 4620
agttaggcta gtggttattg gcgtgcataa ctggaggcga gctaggggat cgttggtaaa 4680
gcagtttctt aggctgctgg ttacacagaa tgtcagtttg tgaaaattca ttgagctaca 4740
cttgtatgtt tattatactt aaatataagg aaaagagaat ttctgctaat gcttacctag 4800
gtatttatgt gtcttacatc atacctgtat ctttaaaact ctctgtcctt tacaaaggga 4860
aacgttctcc gaagaaattt atttctcatt tccaggagat gataaggcaa ctcagggcca 4920
ttattaacga ctgctaatga aaagctctga gttgagaaag gatctctctt ggtttgggaa 4980
gcgctgcggc caaggggcct agggctggaa gtggccgtct tggggaccga agccgcgcag 5040
cccgggatcg ggagctgccc cgacaggagc gcggaggcgg cgagattcgg cccccgcgcg 5100
cgcccagctc ggtttcagca accgcgtgga gtgggcctgc ggccgccgtt cacctcctaa 5160
tacaagcctt tgacagcgct gccagattcg ggaatgagga tcactgcggc gaggcccggc 5220
gggctgggca gcctgactcg gcggctttga gcgctctcag aacccgcggg cgctcgcggc 5280
actcctggag acctgcactt gtctgttctc attgtcaagc gtttcgctcg gatatttgtc 5340
accatcgcct tcatcctgtc atttctaggg tgctctccag tgtcctttat ctcccttgag 5400
cctcacatcc ccctaggatc tagaacaaaa tctgggaggt gtttttatcc tccccatttt 5460
acaggtgaca accagcaact tgcctctgca gacacctgaa agcgatcaga actagcctag 5520
ggctgcggga tcccctgttt tctggttcct cccacccttc gtgtttgtaa ggaagaaggc 5580
tggaaatggg ggtggtgggg tactcagggg ccaaggagct gtgcactcaa gaggtgggag 5640
accgagctgg tcctcctggg ggacttccag cgcctggcct ggacagccga gtgtcatcgg 5700
acttcctgag aaatacaacc ggaagcaaat tgcaaacccc gttacaaaat ccgaatcatt 5760
gagagaaggg cagtagggga ggtccgcaga cctgatgggg tgggaatgtg ggaggttaag 5820
tggtgggcac ttcgaacttt tgatctagca aacatcttcc tcctcttcct ggagacacaa 5880
ttcccctttc catcccccat accatccccg ctcccaggcc tgagctctgg aagccgaggc 5940
tgaggctcca gcctatgtct tcggaatgcg ggcattcttt ggaacaatcg ctttattagg 6000
gacagccatt ccctccgccc tgcggtggcc gcttcctgct tttttatggc ccaggctgcc 6060
ggccgctggc taattgtccc tgttttccag ctgtgtctct gtgctgtgcc ctgaagacgt 6120
ggctctggcc tgctcatcca actgctttgg gagtggccag ggctgctctg gcccctcagg 6180
tcaagccagg cctcagagca ggccaagcca cagggaagcc cgaggctcac ttggagtgct 6240
ccagccatgg aaaggaaatc attgtgaaca cgaatgtttc cctcattgca aaaaatgggt 6300
ctccttagca atggcatggc acagctgtgg tcccagggtc tagacctgtt cggtgagggg 6360
aaaggagctg gtaaatgatg tcctcggaca agcttcttag aatgtaagcg tccccataca 6420
tcctggttgc tctcagccag gagagggccc agctgggtcc ctgaaaaggc agggttgtgg 6480
gagcagtcag agaggggtag aaggtggctg acagaactct aggagcctgg ttgtcttggc 6540
atttagacag ccctggcccc tagcaggttg gtgccccatg actggcctct ggagattcgc 6600
tctgctcagg ggcagcctct ccagcttcta agtgcaggcc tgtgtccctg ggaggaggca 6660
gaagccaccc acatcaaggc cccatgcagg gctttcttag tcctaggccc caggtgcttg 6720
gcgtctttct taggagcctt ttggcctgca ctgagaagcc cccaggaagg gacagggatg 6780
gtcatcccta accctcgatg ccagaagggc ccttctaccc tgtaagtcct gctgctgggc 6840
cagagaagcc tgtagcaact cactctggga gaggcaaact tgtttgggaa gcttgggcct 6900
<210> SEQ ID NO 235
<211> LENGTH: 5100
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_80287 genomic DNA region
<400> SEQUENCE: 235
ttctacccaa ccccatctca tagaactcac aacaaccttg ttgggagaaa aggaggggat 60
acaggggctt aaagaggggg aaataaccat atagctggta ggggctgaaa tgaagcccca 120
agggggtggt tgtttaccct cgctatgact acagagtttc ctgggacctc ctctctttgt 180
tgtgggtgtc cctaactcac cccacggtgc ctgtccggtg ctcctggcag gcgcaggtga 240
cgcgggggtg gaagtctttg tgcccgtgca aagcggcctc cttcctcagg cacttagtgg 300
gaaggatgga agagaatgga gcttcctact cctggccctt gtcccgcagc caagcggccc 360
gggtaggggt ggagtgcagg gaccacccag aagcaccagg cctagctggg tggcagggct 420
gggcccagtc ctctaactgg tctggtgccg cctcctcctc gcccacaccc cgggctgtag 480
actgaagccc gacgtggccc cggcgcctac ctggggcagc tccgccagga cgcgatccct 540
ccgcacgggt gccagaatgt tcatcctgcc tgcggccttg cagggcgccc tgagaaggcg 600
ccgaggccgg atccgcgtca gcgacccggg cgcgtggaga cccgacgatc acccgcggcc 660
ggggtgtccc gactacaact cggggccacg gggaccctac gggagtccgc ggtctcggag 720
acgctacgac caccgcgggc cacggagatg aaacaatcac ccggggccgc ggcgagccca 780
aaatcacccg ggccctgggc gtcccgaaga tgactctggg gcgaggagac tcttcggccg 840
ccaattgggg gcggggagtc ccgtctggtg ggggccgggc ccgcgcagac cctacgatta 900
cgcggggccg gatagttcct acgattacgc ggggccggat ggttcctaca ataacccggg 960
gccgcggaga cccgacgtca tctcggggct gaggctgccc taccattaca gagcggcccg 1020
ggggcgcgga gcggccccgc cacacggggt cagtgtgggc aggggcggcg ctgccaaggc 1080
ccgcaggccg ctggaggagg gggcgagggg cccagtccgg ctacagggcc tcgagtccca 1140
ctccgctcgg gctccgccaa cgctgtaaca cgatccccgg aaattcctgg agaagggccg 1200
ccccccgccc ctctcctggc ggctccaggc ctcgctgccc gccctcgcca ccccctcctc 1260
tccacccttc tgcgttgccc cgctcaggct ccctcttttg acgcttcacc gggcaccagg 1320
accgccccga cccaggctgg agcctatcca gatagggact ccccaggctg ctctcccctg 1380
cacctctata cccggctgcg ccttcatggg gacccttacc cagccgaatt ggtgatgggg 1440
aatcggagac tgctgcgcag catctggcga tgccaggaac cagcagggag gggaaagggg 1500
gagagaaggg gcccaaggag aggcggcgct tccctcctca actccaggcc tgggaggtga 1560
ctcatagagt ctgccccctc tcgcccttct gccctgggag gtcgggggtg aggatggtgg 1620
aggggaagcg tgcgaagggg gtgccagggt tagaatgagg tgcccaccga ggagagagac 1680
gtctgaagtc tggcgtcttt tccttcaagg ctgctgtgta gattgtgagg tgggagggct 1740
gaagatcaag ttccctcgag ggaggttaaa gaagggctaa gtggacccgg aaactctgct 1800
cttcggggtg gtctccgctc tgggaggcgg ggactcccct ctggtatggg tgttcattgt 1860
tctggcccca ttggaatcta tcccccaggg acaactcctt tgtgcaaagt cctgcaggat 1920
agaagagggg gcagtgcaca atcaatttca ccgtcaaagg ggacatgtct ggttttatga 1980
agggagaggg aagaagaaag gatcaagtgg ggatgggtta ggcacacacc ttaggagaag 2040
cgaacctgag tgttaagaaa cctttctctg tgtctggagc tgaatttgag gatgtaaaga 2100
tgaccaggac acggaaggga agactagttt agggcagggg attgtgagtg aagttactaa 2160
ccggaaaaac tagcgaatct tggagaaatg tgtggaattt tcatagaact tcaaatgcat 2220
tatcaggaaa cgcagtaaaa cttgacagta tcagtgtcgc aggtaaagag gggcaggtgt 2280
ggccgccttg tacttcctct gacacttccc cctcgtgact cgattattta tttatttatt 2340
tatttattta ttttgagaca gggtctcact ctgccaccca ggctggaatg gctcattgca 2400
gcctcgacct ccagggctga agcgatcctc ccacctcagc ctcccaagga actgggacta 2460
caggcacgca ccaccacgcc cggctaattt ttgtattctt ttgtagagac agggtttcgc 2520
cgtgttgccc agggtggtct cgaactcctg ggctcgaagc aattcgtcca cctcggcctc 2580
acaaagtgct gggattacag gcgtgagtca ccgcgcccgg ccctgacttg atttttttct 2640
gccaccaaat cactgtgtta ttgataaacc acattcctct ctggacctca gttcgaccga 2700
gcaaatcctg ctccagcact ctagaactta gctgtatcta actcccgagt caatccaaat 2760
gtgttctttc ctcttggcag cgttcctgcc tcctggcatg gcaatcctct tccctgagac 2820
tggcagttgc tcaagatagg aagctcccgg gaccagaccc gagcgccagc cggctacgcc 2880
gtccgctggc ctgagcaaat aaacgcgtgt cttcaaaaaa ctacaatccc catggtggca 2940
cgcgcctgta gtcccagcta ctctggtggc tgaggcagga gaatggcgta aacccgggag 3000
gcggagctta cagtgagccg agatcgcgcc actgcactcc agcctgggcg acagagcgct 3060
caaaaaaaaa acaaaaaaca aaaaacaaaa aactacaacc cccatgaagc tttagtgcct 3120
ttgaggggag gagtggcgca tgtttgttca cgcacgaaaa agaaattaaa cctaactacc 3180
gttcccagag ggcgccgctc tgcaaattac ccaatcagct ctaagtacaa agcatcgcga 3240
gtctttagtg ctctttggcg ctataagccc gtgggaacga gcattggaga cccttttcac 3300
aagatggcgc cgaaagcgaa gaaggaaggt gtgtgttggt gatggggccg cagctggttt 3360
accggggatt gccgcgccgc agagcgaacg aattgggaac acggctgctg ggctaagccc 3420
tgagggctct gctccggggc tgctccctgc gtttcggaca cgctgcagta tacgtgggcc 3480
gcgtgggccc agcctcgtgg gctgagttcc ggtagaggga gttggggggg ggcaacgcgg 3540
caggcatcat ccgccaggga gggccagaca ttcggttctg ggaagctaca tgcatccact 3600
ggttggagct ccatgtcccc gggcctgtaa ggaattagtg ccctcagctt taaccatttt 3660
ccttctggtt catgttcaac cgggctacat tacccgcccc tctctccgca gcgtggtttt 3720
gcgatggggt atgtgtaaaa ttcgtaggac attttctgga aagtatcaag cgttcattca 3780
gtgctacttt gtttcatagt cgtatccctg gagttactta gagttggtcg ctttcgcctc 3840
tggtatcgtg catatgatgg aaaagtttta atctcctgac acttgtgatg tcttcaaagg 3900
aaccactgat gcacctgtgg ccagggtggc ccactgcagt tcttggggcc ggaagtgacc 3960
gatttctaaa tcccgcaccc acgttttctt tccttttctc ccagctcctg cccctcctaa 4020
agctgaagcc aaagcgaagg ctttaaaggc caagaaggca gtgttgaaag gtgtccacag 4080
ccacaaaaag aagaagatcc gcacgtcacc caccttccgg cggccgaaga cactgcgact 4140
ccggagacag cccaaatatc ctcggaagag cgctcccagg agaaacaagt cagtactgcc 4200
ccctgtaccc atgaaaagat ttgggtattc tccattggta atttggaaat tcactcactc 4260
tgcgtgatgg tttctcaaac gcaaattgtg tccagtgtgc ttctctaatt ggaagtatga 4320
ggagattgtt tctgctgcat ttacaaaact ggcaggatca gcccagaggc cgggcgcggt 4380
ggctcacgtc tgtaatccca gcactttggg aggccgaggg ggggcggatc acttgaggtc 4440
aggggttcga gaccagcctg agtgacatgg agaaaccccg cgtctattaa aaatagaaaa 4500
ttcgccgggc atggtggcgc atgtctgtaa tcccagctac tcgcgggagg ctgaggcagg 4560
agaatcgctt gaacccggga ggtggaggtt gcggtgagcg gagatcgtac cattgcattc 4620
cagcctgggc aataagagtg aaactctgtc tcaaaaaaaa aaaaaccctg agtctctcaa 4680
aatttgttag gttaattatt gcttcacatg tggtcacggt ttgaaaactt attttggggg 4740
gagtataaag tagaatacag agattccttg ctcatagctc ctactgctat cgggaacaat 4800
ccttgagggt gagaacgtgg attgattctt gattgatagt ggggattcca ttatctgtat 4860
ttggcagtta tggcctgctg cggtgtatag aagcttcttt ccattcattt tcccgaattt 4920
tcatactgct caaggaacag ttggggggga atgggcagaa ggttgggcac ttgagtattt 4980
gagctatcgg taataactga ctttttaggg agcacagatt tgagtagagc catggtagta 5040
gttagtacca atgggttttt gctgcttcta ctctttctta acagaaaaag tggattgtgt 5100
<210> SEQ ID NO 236
<211> LENGTH: 1900
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_02345 genomic DNA region
<400> SEQUENCE: 236
gtgagaggcc ctggagggct tggctctcct agcttttgag aaagaaatgt caggcagcaa 60
ggaaaatgag gagagagaga agaagaaagg gagggagggt gacagaggag ggagaaagag 120
agacagaata gcgaacaaac ttaatgttaa aattccaaga caaatggagt taaataaatt 180
tacgaggatc gaacccatta attgggccat aaaaagtttt atgagcctca tttacataca 240
atgctatggg ctccacgcaa tggcgcctcc gctccaatta aaaccagaaa ggctgcgccg 300
ggagtcacgg ggctaccggc tcgcaacagc ctggctccgc tcttccggcc ccgcgccccg 360
cgctccgcgc tccccagcgc tgcgctcccc gctcccggtc ccgctccgcc agcctggccc 420
gcctagcgac tgcgcctacc tgaagaccgc atccaggggt agatgcggaa attggcctca 480
gccgcgccat gcagcgcgcc ctcgtccgtc ttgtcgcagg cgcctttggc gaggtcactg 540
cagagcccgg ggatgttttg gtcgtaggag gcgcagggca ggttgccgta ggcgtcggcg 600
cccaggccgt agccggacgc aaaggggctc tgataaaggg ggctgttgac attgtataag 660
cccggaacgg tcgaggcgaa ggcgccggcg cccgccccgt agccgcttct ctgtgagttg 720
ggagcaaagg agcaagaagt cggctcggca ttttggaaca gagaagcccc cgccgtatat 780
ttgctaaaaa gcgcgttcac ataatacgaa gaactcataa ttttgacctg tgatttgttg 840
tccggcagct ttcagtgtcg gttttacgag gtagagtgat atatgataac attacacccc 900
cagatttaca ccaaacccca ttttcttttg gacggagctc gccgcagcac gtgaccgccc 960
acatgaccgc ctccgccaat ctcagcagtc ctcacaggtg gtctcgctcc gcagggcccg 1020
cagccgccta gaatggaagg gcaagaggct caaatatgcg gccaaagaat ccgcccgcgc 1080
ccggcgggcc tggcgcgtcc cgcggaaaaa gacctggagg ctccgcggga gcgcccagct 1140
ggcggccaac ctccgcactg gggtctgcgg acgccaggcg gcccggcccc acgcagcacc 1200
ccccaccccg cccccccgcc gactcctgct agtgagccct ggaccaagct tgggatcctc 1260
cccatccctc tcctgtccgc ctgcccagac cctggaaggg tctctgtccc ccgcaacagc 1320
ctgccccgcg gtggccttgt gggcaggact cagctatgag cagatcgact ctgcccaagt 1380
cttctctcac ccaggtccag tgggcgacag gccggactta gactcggatc cagacgggga 1440
aggcgcagca tctcttgcag ctgcagagag attgccaccg caaactggag ccatgtggtt 1500
cgaataaagt caacgtctcc cagcttcctt tccttaatcg gaggcacact gtttatccgc 1560
cctaaaggaa gcagtgaaat atttatctat taatgagact catttgccaa cagatttatt 1620
aacgtggggt tcccctccct cctcccggac gctgtagtgc tgcaggctct gtgccttcgc 1680
tcctgggcac ctggctggct ccagcagtcc gataaattgc taaagattcc tttgtccttt 1740
ccacaacttc tggttcccct ctggcgcatg gggagccagg gctgtttccc ccagcttgga 1800
aaaatctcgg gcctgcaccc ttccaggcac tcccaatact ggaaggtttc tggggtaggc 1860
cggggtgcct gggaacaata catgctttag agcggatttg 1900
<210> SEQ ID NO 237
<211> LENGTH: 4000
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_36172 genomic DNA region
<400> SEQUENCE: 237
cctcttctgg ggctggcaag gctcagagag gcatttgaaa tggctattat tgacacccat 60
agacttgggt atgtttcaga gagaaactat aacatctatc tcatgggaaa acacactttc 120
tctgttttta aataactccg tttcagcaag atccatgtgt gtagcctctg aatactctat 180
aaaggctccg tatttctttc tttctttcct tagtccggaa tggagacaga agaaagattc 240
ggttgaagat gtccctgtgt ggatctcagt ttgcgctctg agcgacgtcc tggctcattt 300
gggtgtgacg gtgagagcag aggcgctctg ctgacagttt tttcttgtct aagcttccat 360
tccgcatcca caatatgact cgccttccac tccagttaac ttcttggaag tccagagcac 420
ttagtcaaag ctgtttacaa aatgcaaagc atctgggcgg ccaaggcaga ggctcctgtg 480
ttctctatgt aaccgcctcc aaaaaagctg ggaaatttcg cggatcaaaa tgtaggcgct 540
taaagctgac cctctgctgt caatgttggg acttagatac attttttgca tcgtcattct 600
tgtgtgtgtt tcccgtttat tccattctaa ggctcaggct cgcgctgttt ctctcgcgcg 660
cgctgtcccc tctctccatt tcccattcac acatcaaact ccgtcctccg cacccctatc 720
ttcccgtgtc ttcttagtta tgtgaatgtg tgtcattagg cttactcgga cactggatgg 780
gtgagtggga ggcagctttt cttgcggttt catttacact tggcatgggt gggtgggtgc 840
cctccacaat tcgtctcgca cacggaacac agttaaaatc tgtagctaga acgagtgaaa 900
agttccgaat ctttaaagcg cagctaggac aggaaataat acagggttgg gggatgtgga 960
cgggggcgga gagcagagaa gtaaaggaat aaaaccaact tcgctggcaa cttcaataaa 1020
tccggtaact ggaggcaaaa aatagactcc gagggctggg tctggtccgg atgaaacgct 1080
agggctcctt cccttccttg aatcttgggc gctggaagcc agccacgggc gtcttgccac 1140
gcgagtgccc ctagacagca acacacccac tggaaacgca cgtgaacaaa gctctcgccc 1200
ccgggagccg ctgcctgcgg tttcctagtc gatcccagct tctctaggga gtgtcaggcg 1260
cacacagggt taagttagtt ccctccctgg taggagggag aggaggagga ggggaaaagc 1320
agcatactgt ctcaggctgg gtaccttgta gttagttgta cgttcgaaac ctgtcgccgt 1380
cacttgcgcg tttggcatta tccattgtca ccgcggagga acgagcgctc gagatatcat 1440
cagtgcccgc aaatctccgc gccaaggcgc tgagctactc ctttccgagg tgcgcctctg 1500
gtcctccgtc cctggtgccc agcagcggcg aggcggcatc tccgctcccg ccgccgtgtc 1560
caccgagccc tgggatcagg gtggcagttc tcaacgatgg gcaggaggga cctcggcggc 1620
gacccctaaa acaataccat gccccgggat ccccgctgct gccgcgccag cgtcttccct 1680
ttccacctcc ctgaccctgt cggattcgga tgagcccatt gcaaggagaa gacgcagccg 1740
tcaggtaaaa ggggctgcgt tgccaggtga agtttccagt aaccggccga gctgctgcta 1800
cgctggcacc acgctgtctc ttcgggggat tttttttttt tgaaagagct gggggtggtc 1860
atcttaagtg gggtgctcta ggctttgtct ttcacctgga gagaaaatag gcagcttagc 1920
tctctctcga ctttggggac atctgtctgc tggtcgaatc cacctcctct acggagcatc 1980
atgactgagt tctgggtcaa aacgcaaatt ttcttgcctg gtagatgcat cgatgctaaa 2040
ttggggttct cagtgcccct aaccttgtca gagttcagtc tcctacttcc ctagattgaa 2100
tctcttaact ttcaccagta acaaccctct cccctccaca agctgttgtt aatgtcacca 2160
gcgttattat caggctgttg tatctaaaga caccaaccta ctacctgccc gtaatctggg 2220
atctattagc agttaaacag atgcggtgga tactaattcc ttttccttcc agttggtggg 2280
ggcgggtggg gctttttcca aaaccaagtc ccttccagcc ctgcttgtcc tcttcgggct 2340
ggcgggcact gagctggggc catcacgcct ttctagagcg cctgcggagg tggcgaaggc 2400
ttggagagca tacgaggcgg aatccggatc gagtgagttc cttgagccgc ttgcgtggga 2460
cgcagggaga gggcgaataa cgccctcagg cgctgaatgc aggggcaagg agccagcgag 2520
ggtggctgga gcaggccttg ccagctgtta ccaagtctct ccacaggctt gggggcttgg 2580
ggcctcctgg aaagatccct ccgccgcgct gaccagtacg gggctcgctc ccgcactttg 2640
aaggctgccg cggtctttcg tcatttataa tcaagcccaa gatcaaggtt gcaagctgag 2700
gtcggggtac tgacaacggg aatgaagcca taggggaaga ggataactgg gacgggctgg 2760
acccatactt gatacccggg aaactcctag agcgtgtggt gctcctgcca gcggcagtta 2820
ctggtggagc tgaggccacc gctactgtcg tcgttggcgc tttgcttctg gaacctccca 2880
gcaagatggc actcactgtc tgttcccttc cgattagcac ccccagccgc gctccctcct 2940
ccccgggata cgtattagtc acatactgtg gggagaagat gggctatgta aatgtaagtc 3000
aacgcgcttt cccagccacc tttgcataat gcaacaggaa cagcgacccg cgcgcacgaa 3060
ccgggtagtg tgcgcgtgtg tgtgctcgcg tgtgtgagcg cgtgtgccag cgtgcgtctc 3120
cgcgcgggcg tgcgtctggg tggatccttg cgtggcttgg gaggcaaatc gggcgtttct 3180
ccaagtcgtc ttaacatgat ttaggctctc aaatacgtga aagcggtaga cacaacaggg 3240
atgcgaagga aataaaaaac aattggggaa gtggtgccaa gtcactcagg ctttgaactg 3300
aggacgagta gtgcggtcgc gcctggggcg cgtccggaaa tcatcctcag cctgtggcgg 3360
ccactgcccc acttaaactc ttctgcgggg agagttgagc ggatccctgg ggggttggtc 3420
ctgggctagt tttaaactct ccggttgcat ctcgcgtggc cccaccgacg gcgcgtctcg 3480
gcgtagctct tggcgcgggc tcgttctccc tcttctgttc agattcagcc tcaccggact 3540
tgttacaaca tgacagcaac ttactggagg caggaagagc agcacgaaat aagatgagaa 3600
aaccaaaaac atctcctcct tcctaaatag agacgtgcac ctagcttttt ttacttgttt 3660
gtttgttttt tacattaccc tttaaccttt ggaaagagac tgcgaagtgg aaacgttgcc 3720
tgtacagaaa tcaggcttct tagctgtcaa gactgtttcc taatctttag gctgaatctt 3780
tctttgtccg ctgcaatcta tggggaaatt taacaacgct cttgccagaa gcagccaggt 3840
tgaaggaaga aagtgggggt gtttaaatta atcctattaa attttggatt actcccccag 3900
ttaaagtcat ttaaggtggt ccaggatgag ggaactagtg atggggtgag gagtgggggg 3960
cacatcacca aggttgcctg catttgaaat aacgccattt 4000
<210> SEQ ID NO 238
<211> LENGTH: 3500
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_70459 genomic DNA region
<400> SEQUENCE: 238
agtgttgtta agtcttaggc agaaacttca aaatataaaa tataaagctt cacacctcac 60
agataacagt gtagttctgg ctgacatggg agtgggagtc tcacagtact acaggctgct 120
gcactcattg ttgctgtctc catggctcaa ggtgtctccc ctgaatctta aaagttcccc 180
tgaacaggta aactgtaagt tatcccagcg ctttgggagg ctgaggtggg aggatcactt 240
gaggccagga gttcgagacc agcctgggca acaaagcgag acactatctc tacaaaaaat 300
aaaaaattaa ctggacacgg tggtcccagc tacttgggag actgaggcag aagaatcacg 360
ggagcccagg aggtcgaggc tgtagtgagc catgatcttg ccactgtact ccagcctggg 420
tgacaaagta agactctgtc tcttaaaaaa aaaaaaaaaa aagaagtttc cctgaacact 480
ttgaaaacca gtagtctaga tactcttaat aacggccagt actagctggg ctccctgaac 540
caatgtaaca ttgaggtgta gcctcagtca agtggccctt caatacttcg cccaccctag 600
ttatatgggt cctggatggg atggtggtaa ggtggtgaca acaaaatggg ggaggggggc 660
cgggcgcggt ggctcaggcc tgtaatccca gcactttggg aggctgaggc gggtggatca 720
tgaagtcagg agatagagac catcctggct aacagggtga aaccccgtct ctactaaaaa 780
tcacaaaaaa ttagctgggt gtggtggcgg gcgcctgtag tcccagctac tcgggaggct 840
gaggcaggag aatggcatga acccgggagg cggagcttgc agtgaaccga gattgcgcca 900
ctgcactcca gcctgggcga cagagcaaga ctccgtctca aaaaaaaaaa aaaaaaaaaa 960
aaaaattggg ggagtgggga ctgaagaatg tcctagtaca aagaatctaa ggtgtggagt 1020
cagacagata tggatttcta ttcataattt tctatctttt ggcaaatcac tttacttctt 1080
tgggactcat ctagtcttcc caggtgcctg cacctcagtt attaatgaaa aggaggccgg 1140
gtgtggtggc tcacgcctgt aattccagca ccttgggagg ctgaggtggg aggatcactt 1200
gaacccaggg gttcaagacc agtctggcca acatggcaaa actccgtctc tacaaaaaat 1260
acaaaaatta gccaggcatg gtggcacaca cctgtagtct cagctactcg gaaggctgag 1320
gcagaaggat cacctgagcc tggggaggtc gaggctgcag tgagccgtaa tcgcaccacc 1380
gcactccagc gtgggcgaga gtgagactct gtctcaaaaa acaaaacaaa acaaaacaaa 1440
aaacagactt aagtatatta caaatccgtc gtgatcctct caactattct gaggtaaatg 1500
ccacacccac tttttttttt tacagctgag gacactgact cacagaagct agatggcctg 1560
ttcagcatca cacagctaat aaaatgtgga gttaacccac attgatccta cttccaaatc 1620
ccagagtcct tccatgttct agtctttggt taagaatgct tgagagaagg actagaggga 1680
ctttatatga agtgtaaagc tttattcata caatagtcct cactagtgct gtgtgagaga 1740
gagaaggctg aggaaagcgt cggcggaaaa aggctgatcc aaggggaaag ggggccggaa 1800
ctggagggca ctggttctga gaggagaaag ggagatgggg aggtctgatg ggcaggcatc 1860
ccccaaagcc cctgagaaaa ttcatttgag gaggagagaa agggatggcg tgaagctgga 1920
ggaaaaggga tcgaaccgga tgcggcgagg cctgaactgg cctggcgggc gccgacccgt 1980
tctcctctca ctcagatcag cgcccctcca ccctcccgtt ccccagtcca gctttcccag 2040
agatgtcagc atctctgcca tccctcatcc ctcgctccac cccacacgcc cgccgtacgg 2100
accgtctgcg acagctgcta ggcctctgga ctagatccag gctgtcagcc aaagcccatg 2160
cccccaaagt taccagtcct cctcccctgc agctgcagac gcagacgccg ccatatcttc 2220
accggcccgc agccggaacc ggaaatgccc ttagggaagt cggaggcgga aaactaagag 2280
gggtgggcag ctagcgtcgt ttctaggcaa ccgcagactc cgggtcctta gccgggcctg 2340
atggccctga ggcagttcgg atgtgtccca ggaagtgccc atgtgtggtc cgccgtccat 2400
tccacacctc tgagcgcctt tgtcctctga acttctcacc agttctagcg agtaaaattg 2460
taagaaaggg agccgaaaga gaccggaggg agaggcgggt ggagaagaat tataagtcag 2520
gcaacgtatg caggcagcca gaagagatgg ggctaaacgc cagggaatcc gtcccttggc 2580
ctgaggagct tggagctcct aggctggggg tgagagaggg gctctggcct gcgaagcgca 2640
cgggccaggg ggtctgagag cgggtgctga ggagtctggg agtggcagga acttggggga 2700
gactcaaagg agcagggttg gttgggcgag gctaggttga aagagtaggg tcgagtgagc 2760
caggctgggt gagggagaag gggaaccagg tgttagttgg gcatggggcc gggttgggga 2820
caggaggatg aaagtgggga ggaactacaa agagaagctc tgtttgttcc aagagcgcat 2880
catctttgca tgcattccac cctcccatgt tttttgaggc tttattgtga aaaagaggaa 2940
aaggcaaggt ggctaacatt tttcctttcc cgtgccccaa ctaggcgtcc cagatgttgt 3000
ggaactgtcc ctggatctat agctcttcac cgtctctact ttcttccttc taagagatcc 3060
tgaaacctct gtcatggaaa agtaccacgt gttggagatg attggagaag gctcttttgg 3120
gagggtgtac aagggtcgaa gaaaatacag tgctcaggtg ttgcacaaag agggatacct 3180
tttgggtggg atttggtacc cccaactcca gtggaaaatg gatctagaag gaatgtattt 3240
ataccagttt gtattcctaa ggtactgact ccctcatact tcttatggag tataagcttt 3300
gaagttggat tatttgggtg caaattccat ctccaccgct ttctagccct agaattatgg 3360
acaaattact taacttccct atgtctcaat ttccttatct ctagaatggg gataagaaca 3420
gcaactgatt gatggagttt gaggattaaa tatgttttca cattaaatca cttagtacag 3480
tgcctggctg ttagtaaaca 3500
<210> SEQ ID NO 239
<211> LENGTH: 2700
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_105937 genomic DNA region
<400> SEQUENCE: 239
atgcaaaaat attaaataaa attttagcaa ataaaatcca gtctcatatt aaaagaacaa 60
accattattg acaagtatgg tttattccct caggaataca tgaaattggg aaatagagca 120
acacaaatca aagaaaattt taaagagaaa aaaataaatg aaaataattg taatggtcaa 180
aagcccttag gaaagagaaa taaaaacttg ataaatcaca gtaattattt attcagacca 240
tactacgtac ctagtactac actttgaaca tacttaaaga acatttgctc acttaatctt 300
cataatgatt ccatgaaaaa gaaactatga cagctttttt ccacaaataa ggaaactgac 360
tcagagatta acgtacccaa gtcagaggca gaggcaggta cttcttactc cacagtccat 420
acacttgcca cctggctaaa attatttgca gatgacaaaa atgctcaact agaaaaaaga 480
cgtcaattta taagttatat gtaatgacat gagtacaatg aagtgacaga ataaacatat 540
atatttttaa cttctgttct tgtcaactaa gtaaaattag gaacaaaaaa ggaaaggggg 600
aggggtctta tgcaaaaaaa aagtcacgat ttacaacaaa aagtattaac tatgtagaaa 660
taagcataac cagaaatgtc caagatacgt atggaaaaac actacagata gtcaaacaaa 720
taaaaatatt gggttaatag aaatccatca catgttcctg aaagtgttgt atctagatct 780
acatcaattc tacccaaatt aaagcaacca cttgatgaaa ctgcagcaat ttaaaaaact 840
ctcaaagagc atgtaatatg ggaatacgaa gttgacaaga tgttattaaa gacgaataaa 900
attataccaa tacctagaca cctgatccca acattaaaca tgaaatacac taaaccagag 960
ttattttctg gaggagtatt taaaatgatg gggatgttat tacttgggtc gcaatgaacc 1020
tgaaaaccca ttttctacag aatatacagc agcagggaag caaggggacc agcagacccc 1080
tttttaagta cgcatgtgat aagcaatgaa cacgaactgc ccagagcagt ctccaacact 1140
gacacgattc gcttccccac cacgacgccc tagcgctact gtgcaacgaa gacctcccaa 1200
gcactggttc caatgcggag accatgggct cccagactct gggaactcca acacgactgc 1260
gaaacgaact ccgagcgagg actccccgag agctccccgc aacacggacc tcacgcgcta 1320
gcgaacaaca gaaaaaaaaa agcgcgctct ccctgcccct gaaacattcc cagaagccca 1380
cgcagaccag accgatgacc tgtctccact gctggaggcg agtcagggac ccgaagtctc 1440
taaacactcg cctctacccg ccgccccgcg aaccccacac actgcagacg cgacactcgc 1500
aagtttcggg gatggcggcc ggcgagggcc atactgcgtc tttccggaga cacggaatac 1560
ggcaccagcc gtccctttat gatgcaatat gtctgcgccc aggggacgct tgctgggagc 1620
agccattttc aaccctactg ccgtagagca ggcggagtcc ctcttttcgc gccttaagac 1680
aggtaggttc tgacgatgaa aagcaattga aaacgaccca tttcaccctt tttccagtcc 1740
acgtgaactg ctagatcttg gctttgcaac attagccagg ggcgctacat aaactgctta 1800
gtttctcaaa ggctcaagcc tgccctgatc tgtctacagg atgggtagag atggtcacag 1860
acatttaggc actttgatcc taagaagaat ggaaagaaac catgtggcgc ggcagtctta 1920
caggaatttc aagagggagg gacctgagca acaatcggag gggttattac tcctgaggat 1980
gcatctggct ggagaaagca gcctttgaga actgcctaag aagtatcttt acatctacat 2040
cagatgtagc ctcagaggaa ggagtcagtc atagaatgga taaaacaacc gcgtgttaaa 2100
gctttggtta taattggtgt ggagaatgga gaacacagtt gatcagcagt tgacaaagtg 2160
gggaaccaac acgaaaacag ggctctctca ccctggaaaa gccaaaggca gaacaagcct 2220
ttacatccag gaaggtggga gcaacttgaa atcaaaactc tgaaggggag atgattctgt 2280
tcaatactga aactcagctg atcaattaac tgatgaattc tagcaccaaa cctgctccct 2340
ataattttat aaccagcctc agagaacctt taaagggatt gatcattcac tcatttatcc 2400
agcgaatgtt tataaaatgc ctaatgtgtc aaacactgtt gtgcgtgctg ggaatacaac 2460
agttggaaat tcaggcacaa agactctcat tcatggagat tacattctac tggcaatttc 2520
agtgtgtgag ctaaattgag tggtgctaac tgttgacttg gctggttgac tgaaacttgg 2580
actcaaaatt tgcctacact aaatgaagtt taaatgccag aaatttcctc atatattata 2640
aagtacccaa agataaatgg agtttggaat gctagaatga atttatcatg taaaatcaag 2700
<210> SEQ ID NO 240
<211> LENGTH: 2700
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_89099 genomic DNA region
<400> SEQUENCE: 240
agaaagttcc tggataaagt agacttaaga tcaacggcat aacctgggta agcaagtagt 60
atgacggtca tgtgaccttg gcattagtat ctcttgccga ggatcttcat ttattggctt 120
gcagtttggt ggaaacacct ttctggttct ttctgcaatc atgtatgata gtcatgcagg 180
aggttgtaca gaagtgctcc accccaccca agctcctcct atataaaaag tgcaagagtc 240
ccaaggacaa agaggagggc ctgaaggacc cactcttgtg ctcggcgtgg tcaccgaagg 300
cttaaataat aggcttggag aaatggaaac aggcagttcg ggaactgaca aggcccttcc 360
tacaaagcag aggacgaaat tagccactgc tccagagtga gcacatatct tcactcccgc 420
tccctccacc aaactgactg taactccagt ggaacaccac atctctagtc tctaccagag 480
gttcctgtct cggctccttg ctatttcagg gccacgcatc ccttcccctt tcatttcaga 540
catgcggggt gacagcaggg tcggcctcct cacgcgttct ggactgcggg ccgagggcgg 600
gcggcgtgca cttcaccccc aggagccaga agggaagcgc ggcacatggt cctgtagctt 660
cacgcagggc tggcggccag ccaagcgcag ggccctttaa ggcgcgcagg gtgcgcacgg 720
gtgtgggagg gagaccccgg cgccggaggg cctgcggtcg cctcagcccc accctgggac 780
ggcgtgctcc ctcccctcgc tgctcacctt ggttcccaag agccgggcgg ccgcagtaag 840
taaagccatg gcgggcgatc tccgggatct ggtggggagg taagaaaggg agagagctgc 900
ggcaggaaca ggagccgccg ccgctgcacc agaggccgcg ccgacgggtt gacaaggttg 960
aaaggaggcg gctgaaggaa agagtagacg aaccggcggc ggcgcccagc ccggggtcct 1020
caaggaggcc ccgcccactg gccggaaccc gagcccgccc ctctcaaggg actctccccg 1080
ggcccggcca ttggtccggt atggaagcgg ggcgggacct tagcccttga cagcagttgt 1140
gacggggagg attggaccgc ccggattagg gctaattaag ggtggatggg tggcgggcgg 1200
ggaagtgcgg gtggctaaat aggtgcctga taactcagtt aacttccctc ttggcttttc 1260
cctttgacct taacactttt ggggttatct ctgaggcgaa tgctaaagga gacgctccag 1320
gactcgacct ctgaaggtcc ttggagccaa ttccgtaata tgatcatgga aactgatcat 1380
tgcctgatcc ttctaccgcc ttggcgcgct ttcttgagga atgtctttgg ttaatggctt 1440
cacggccatg gaggtgacat catgtggaca acaggctagg atgccagagt tagctgctcg 1500
gtggagatca tttgaggtca gcagaggcca cgatattata gatactaaca gaccccgata 1560
tggggagaaa agcaaaagca ggagcctgaa tatccagtgc tttgtgagct gtcagttctg 1620
tgtgtaatgg caggaaatcc aagtcttaac tgcgccctta ctatgaaggc tttccgagcc 1680
agccacagct tctgggtcat gggcattagt ctcactgcca ctctggtcac gtaaccccac 1740
acagcagctc accccacttt agccacagat taggagccgc agactagccc ctcatcgaag 1800
atcccctttg gtcacattct ctagggcctc tgggccactt ctcctacttg gcagtcttct 1860
atgctctctt atcttgtgct ccccagagac catgacacga ccctgaagtg atattccgca 1920
ccactttcta aatcctctgg gtagacgagg cttcaggact tttgtgcctc cctaagcctg 1980
tcgtagtcat tgaccccaag gacaagagca tcttatctac aaacctccag ccccaagtga 2040
aaagcctttt ttttttttgg agacagatct tgctctgtag ctgaggctgg attgcagtgg 2100
tgcgatctca gcctcctgag tagctgggat tataggcgcc cgccaccacg cccagctaat 2160
ttttgtattc ttagtagaga tggggttttg ccatgttggt cagactggtc tcgaaatcct 2220
gacctcaggt gatccacccg cctcgggctc ccaaagtact gggattacag gcgtgagcca 2280
ccgtgcccag ctgtgaatag cccttttatc tcaccacata gcagtaacaa ggatcacagg 2340
tctcagtatc cacctaagcc aggtttagat agatctcctt tacaaagaac cgagtttcta 2400
gcttggactt ggaaaaagag atagaaaacc cctattttct cttcttaatt ttctttatac 2460
tcagcttcac acctaacaac caatgctctt ctggcctggg gatcagatag ttaggtctca 2520
ggaaaaaact ttaggcaatg ctccagagga gcactgacct cagctacctt tgaagacccc 2580
ggtgacttca aagcttcact gatcaatatt tgctccccat ttagcatctc ataaaggatt 2640
tccacataac cctagaatag tctgacctgg ttccttttct ctggttaatt atccacagag 2700
<210> SEQ ID NO 241
<211> LENGTH: 4000
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_03099 genomic DNA region
<400> SEQUENCE: 241
taaatgctat tttattttaa acattttagt ttacaaaaaa aaaaaaaatc aatgattggt 60
acctttttta cactctcaga ttcctgaata tggacagatc ttcaaaggga ggaaggagtt 120
ctcatatgaa atttaagata gactgtcctg aaggttgtgg ggtggggttt tttgttgtgt 180
tttaattcgc ttttgttttt aagacacaat aaagctaaaa tgtcaagtct ctgggagaga 240
tccccttaaa gtttcagtca aggagcatat cagagcacag acaaggagac cccagcctgg 300
tgcccgccgg cccgtcccgg ctgcccaggc gtatttggta gcgcatgggt tgagagccac 360
tgggacaatc acacctcgca ttccctcgcg ggctgctggt ggcaggtaca cgagccatac 420
tcgttgatga tcaccagggc tccctcaatg tggttcggtt tgtaatcaac gtagtattcc 480
tgggcagaca tggcagccat ctgatgcatg gtctgtttct gcttttgctt cctgcgctgc 540
gtgacaaagc actgtctgag ctgcctgagg ctggctggga aacacttcca ggacacgtag 600
agcaccagga ccacgatgag gaaggagaag atgagggcca tggtgcccgt gaccaccttg 660
tggatctgca cggcgttctc ggcgtgctcg ccgcctggaa gagccacggt ggcaggctcg 720
aatgtgccgt cgtgctgccc ctccccgccg tccgcgagcg tggtggccga gctggcaggg 780
ggccccagat cactgcggtt ggtgacggcc gagagcaggt ggccgctggt gggctcggcc 840
ccatcctcgc acaggtggaa ggcgtacacg gcgtccagga cgtcctcgcc ctgtgcgtac 900
tccgggctgg cgcactgcaa gttgccatcg tagcgcccct ggaagttgtt gagccacgag 960
gctagggcac acacgttgcg cccgcaatcc cacaggttcc cggccagggt gatgcttgtc 1020
agggacttcc aagagttgag gatccggggc tcgatgtagg tgaggcggtt ggagtccagc 1080
tgcagggact gcaggtgcgg cacggtctcg aacacatggg gctccatgta ctcgatctcg 1140
ttgcccgaca agtccatttt ctccaggttc caaacccagt ccagcgagct gaccacaatg 1200
gccaccttgt tcctccgcag gcagagcgag tgcagggaga tgaggcgcgg gaagtgggcg 1260
aagttcacct tgaccaagtc gttgtgctcg aggtgcagct cggtgagctt aaacaagccg 1320
gcgaaagagt tgcgcgccag actcttgagc tgattgtatc cgatgtcgag aaacttgagg 1380
ctgcggcagt cctggaagat gcgcacgggc acaaactgga tggcgttggc ccgcatatgc 1440
agcgtggtga gcttccgcag cccgtggaag aggtcgggcg cgagcgcctg cagcttgttg 1500
tacgagaggt ccacgctgcg caggttgggc atgggccgga aggtggtgtt gggcagttgg 1560
gtgatctggt tggaactcag cgtgagttcc ttaactcggc gcagtttctg aaaggcgtcc 1620
ccctgcacgg agcagatgtg attgtgatcc agatagagcc acgtgagctg cattaacccc 1680
gtgaactggc cggcgcgcag ctccgagagg ctgttgtagc gcagggacaa gcccagcagg 1740
ccggacaggt tgtggggcgc ctcggtgagg ttgagcgcct cgcagtacag cagccgcccc 1800
tcgcaccggc acagctgcgg gcacccgctg ggggcggcgg gcagcatctg aaagcaggcc 1860
cccagcagac acaagaccac ccccgagggc ctcctcagca gccagtatag acagagaccg 1920
agcagcagga aatccattag cgagaatctt tccagagaga ctggagaatg tccattggaa 1980
gcgctcggtc agaaatctac atcatatttt attccgaggg aggggaagcg ggggaggggg 2040
agaaaagggc aaaaaatcaa ataaatacat agaaataaag aaggaccccc ctccccaaaa 2100
accacacgtt cacctctaag catgcagaaa gctgggcagc atagaaagtt cacagccacg 2160
gaaagatcaa agagatggtg atttggtcca tgttagatgc tgcagcaaag aaaagggagg 2220
aaaaaaaaaa tcttcgggaa agaatttaat taaaaagtgt cttacccacc cttttccaga 2280
gagtgacaac ctccattcag ctgctccctt tgtgtgcagg ctaattatat gcagggcgag 2340
agaagacccc tctgtgtttc cgaggcagcc ccggtccgcg gccggcggat ctggcaggcg 2400
cacaatgtct cactttgctg ctcggctcgg ggctgcaagg gcggccggca aggcggggag 2460
gcgacttcta ggacccgcaa gtttcccaac tacgtgccgg agcccgagct tcgccttcct 2520
gccgccttcc tttccctctg cagttcggac tgtgacgttg tggggggaaa aaactccaaa 2580
ctcggggctc gcgactcccc aggatctgac agtctggtta atgtccgtca ttggaaacga 2640
ccactgaccg gcgccacctt ttactccgcg gaaacagcct gccattcgcg ccccgggcag 2700
ctgcagagag cgggctcact catgctttgc gggcggcggg cggcgggcgg cgggcggtgg 2760
ggaggtgcgg acggcggcgc ggggagcggc gagcggcgcc cgggctcctt ccctccacca 2820
ggcagtgtgc ggcgcgagct tgcacaggca cctactgctc actgagtgtc gtaagctgct 2880
cacgattgtg cgtcttcccc gagcacctca gacatgggca gattgaaaag gggtgggcat 2940
aaaaccaaca ttttaccgaa ccactaaagt aatatatgtt ttttgatgaa acggaaaaca 3000
ctttcagctt ttttgtccat atttcaaaaa aaaaaaaaaa aaaaaaaagg aggggggagg 3060
gaggtggagg taggggtagc atcatccacg acaagatatt tccaagtggg aaactgaaat 3120
gttctgtgct ctcccccttg ccttttgggg atatattctt ttccccttta aaactgtcta 3180
cgtgtaagag atacgtagga atctgtagag aaatcaacgt ttggaccttt gctttagaaa 3240
agcaacttga gagaagacac aggaaggcaa tgatttgggg cttggctaag atttttgggg 3300
ttttttcccc ctcttgcggg tactggaatt ctgcagtcag ccagcccttt tttgaggtgg 3360
agaggggaaa tgctttccaa acccacctag tttgggaagc catccaagtc ccggtggtgt 3420
gagatccagt gtggcaaaaa ggtatgtctg tgtgcaggga gacttgactg agatccctcc 3480
ggggcttcat caggctccac agatacatat ggggtacaga gtggattaaa gaacgattgt 3540
actgtctgac atggggaggg cttaccctga cttgtgctgt tcatggtgat tactgggccc 3600
tgcagtgcac cccactccaa gagagtgtga atgtgtaggg acgtgatagt ttaagccata 3660
atgaagccta cccgtctcca tacacacatc ctaattaatc tttgagactg cactaagttg 3720
tgccactttt tcctctgagt atgacgagaa gcctttgcct cattatttct attcataatc 3780
atttatagat aggagtcctt acaatgagct ctccccccac ctccccacac acacaccttg 3840
tgcctactgg tctgtagagg gtctgccctg gggagggtca gttggtcatc tgtttaaaca 3900
aagtcctcca agatggctga gaaagcctgc gggaagtgag tgtgggcaag ccttccttct 3960
tgacaaagat gcccagggag atggtaggga gagtcaaatg 4000
<210> SEQ ID NO 242
<211> LENGTH: 8900
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_67625 genomic DNA region
<400> SEQUENCE: 242
ggctccttct ggctgcccct agacccacca gaggggcagg caacagagga gggtgagctg 60
gaggctggag gggccaggga agacggacag ggagggcgcc tgcctcccac agaccccaac 120
cagcctgccc tcttcaacct ttccctgctg ttttccccag gactcctttt gccctcacac 180
tccagtctct ctgtagcacc ctgttgctcc ctcttggtga tccagctctt gaaagcctct 240
ccaggcctcc cgctctttcg gaagccgtgc ctctccccct ctgcttcctt catctccgag 300
tctttgtacc cctgcgtctc cgactcggcc tttcatctgc tccctccacc tcggcatcgc 360
cttgcctcag tctcccccga cccctgtctc gccccctctg cttccagaag cctgcgcctc 420
tgtctctccc accgcccggt ctcctggtgt ccccggcgtc tctcccgtcg ttcccgccgc 480
cttgatcagc ctgggctgtg gcgctggcat cgctggcctg gggaccgggg tgtgggcgat 540
ggaagggggt tcgagaggcg caggggaggg gcttcccctc ctccgcccct gggcgcctgg 600
ggagactcgc gtgccagtca cctgccggtc ggggcgccga cttcgcgcct acgcactcca 660
cgtgggcgcc ccggggcgcg cctttgtctc tcccgagcct tgaaagctaa ttacattggg 720
aggggacagg ggtggggtgg gagagggggc cgctgtcccc attcactgag ccgaggccgc 780
cactccgccg gcagccccgc gcaggcctgg ccccgagtca cgtctgttga aaccgttttt 840
ttcggcctcg cccccacccg ccttggcagc cagccgcgcc tttgtacgcg ccggcggggg 900
cgccctggaa ccctgaaccg tcttacgggg aacgggggtg gggggagggg agcggcgcgg 960
gccccacgcg aggaaggaat ttcctgggcc actgcgaaag attgaggctc agaaagccag 1020
agagagacgt gcgaggagga agcggagagg gtgtgcgaag ctggagaggg agtcggagcg 1080
ccagcgaaag aggggagcgc tggggaagga ggaagagaag gagaggggga gaagagagac 1140
gcggatgctg ggcgcgcgac ggcagcgggc ggaggagggg agcggccggg aacctgcgcg 1200
caggggaagc caggacggag cgcagcaccg gcaggggagg gttgccgagg ggctgtgccg 1260
aggagcccgg gtgggggcgg ctggaccgcg ggccgcggga ctcacagaca gtgcgaggcg 1320
gcgcgggggc ccctctccct atgcggggct ggggcgcagg ggctgggcgg ggcgggtggg 1380
cgtctgagcg cggcgcgggc gcattcttcg ccttttcttc ctcgggctca ttccggccga 1440
tcgatacctg cgcgggacct gcccccgccg ctaatatctt tttaatgagt tcgccaggct 1500
taaagcgagc gcgatctgcc ctccagggtg gattttcccc cggcagatgt ttcgggagga 1560
ggaggcgcgc ggagctcccg ggagggggga caaatctctc cctccgaggg gcgagaacag 1620
gagactttct tctaaagttc aaaagaaaga cgggctttca ctcggccccc aaaaatgtat 1680
ttctcggcgg acaatgggct tctttctgcg cctctgaggg ccggcggggc gggcagggcg 1740
gggacccgtg cgctttggcc ccgcctgacc gactcgcacc cccctccccc gcacccaggc 1800
ccgggcccca gagcgagggc gcaggagccg cgaagccggc cgcccttccg agcgtccccc 1860
tgaagcgcac tgtcgggacc tggctctccc ggagctaagc cccggcgcac cggcgagaac 1920
gaaagcgtcg tgcggggccc tgggctgtcc cacacgcccc cgttctcata ggtgcctcag 1980
ccgggccgaa gggacgcgcg ctggtgcctc aaggggagga cgaacggacc tccgggcttg 2040
ggccgcggcc tccttcccct cggcgctccg ccctgagcgg ggcaacaact agaaattagc 2100
caaccccggg cggctgccgg gccctgagac tgtcttgccc gccccggccc agccacccct 2160
ccgggtcgcc cctgctcttc tcctccactt ccccttcaat gtccctccgt ggggccgtcg 2220
gcctgccgcg gcggccctct ctccactccc gtgggctcag gggaagaggg cacccgggcg 2280
gcgaggatga cctccgaaga gccgcggcaa attgattcgt tccgcccgga gccggggccg 2340
cgtgaatggg ggcccgggcg gcggcggcag cggagaagag gataaagatg ttctccctga 2400
aagggggagg gggcgcggag cgggaagcgg ggccattcac tcctggcccg gcccctcggg 2460
aagccgcgcc gaagaaaggg ggccgaggcc tattcaagtc ctacgagccg cccacaatgg 2520
accgatatac tgagggcctc tctattaacg cccatgaata ttaaagagat cgccaagtgg 2580
cggccagcgg gcgagggggg cgacggagcc tgagagctcc ggcccggccg aggggagggg 2640
gcttttgcgc gagcacattc cgcgcctggg ccccgcggaa aatgacaaaa taacacgggt 2700
catccgctgg gaaagcccgg aatgtttccc ctcgaaatct cctcccgggg agatgtgagc 2760
acagggtctt gctccctatt tcaatgcacc ttgagactgg gcgctaccta cgggctcctt 2820
tttccccggg cgggggtcca ggtgggtttt gccgctagac tagaagcaca aaatgtgagc 2880
gcggtggaga tttgggcgca ccagctggga ggacgttctg cgctccgctt ctgcccggct 2940
cccagtactg ctctccgggc ttgcgggtcc ggaggagagg aatgggactc cctggccgca 3000
gtccgagccc gtggtcactg cgccagcgga atccaagcct ctaactctaa gccggggttc 3060
aggacccaaa cgctgcaccc cagcacggag gatgcacaga cctgagggct tcccgcagtg 3120
ggacgtggcc ctggagaggg caaaatcctc ggggttgtcg tggggtaaag tgatcttacc 3180
caaagagaga ccaagcaaag aaacctcagt tcacaaagtc caactcaaac cattgcacag 3240
acagggacac cgaggcccag agaggaaagg ggcagtccac aggacacaca gcagtcctta 3300
tccccctttg gtgtcctgga ggaactgagg tcgctttcgg ggcttgggag ctgccgcagc 3360
gcttggctcc tggcagcgct ccccgacgtc gtctccctcg ctcctagcac tttgtcctct 3420
ccacctaggt cttcccagaa gccaagaagt aggccccggt gaggctcccc tgcaggagcc 3480
atcggactcc atacgccccc tcagactcga gctctggcca gggagccgat gcgacccaca 3540
agctgcgtcg aaaaatgagt ggagggttcg gcgaccctaa cccacctccc tcctcagcag 3600
cgctgccctc tgctggcgcc ctgcccaacg gtcctgcctt ctgccaggtg tgcccttcct 3660
tgggctccag cctcgggcgg acccggacgc agggtctgaa ggccagctac cgccgccttc 3720
ctccctttgc gtcccaacgg ggacggggga tgccggagac tactggcagg aactggggac 3780
caggggtctg gagtctggac gccaggtgtg agaccctctt agccaaggcg cgtccgggtg 3840
gtggaggggc gtctatgcca acaggcgttt ggacagggtc tcgctcatgg gaggtcagct 3900
cgctgttctt ccacccaagt cctccgcgct gaggagaagg tctagggagt ccacacagtc 3960
cagcggagac taatccgtga gcctgaccca cgccgagagg gtccaggcac ctctgttagc 4020
ggcatctgaa attgtaggct ggtgatggga gccagaagtg cggcaggtgg ggtgagctcc 4080
ctcacccagc atgtcagggc ctggggtccg aggcttgagg ctgacactgg ggagccgcga 4140
agcctgcagg aagcggggcc ttccgctggg ctcagcagct acctgcttcg ggagagggga 4200
tcgctgggct ccgaggtgcc tcgaaaccgc cgcaaagcaa gtctgctcct gggatgatgg 4260
gcaggaggaa tagaggagag gaagggaaag aagagagagg cagaggagaa agaaagaact 4320
aggaggcaag aaggaagggg cgccgcaacg ccaccggctt cccgaggttg cagctcagca 4380
aggagccgga aagccgggcc gcaagccgaa cccgcactga ggcctctcgc ggagctgcct 4440
gcagtttctg agggacttcg ctctcaggca cgcctgctcc cacctaggaa gggtctcggg 4500
acccctttca atccccctat atcccgtagg aaattctttt cccagagaca ggctgccagg 4560
gcgattcctg tccgcccatc tcgacccccg acctggcccc gcaagggccg ggagcctggc 4620
cttccatgaa gctgtctcag gccgggacca gccccagccc cgacggccgc tgcggccccg 4680
cctcggcagc cccgtgagcc cgcggaggag tttcgcaccc gaccgtgcac agcgaccgag 4740
ttggcgcggc ccgtatgaag cgaagcgccg gcttcagcag cgcagtctga gcaggggatc 4800
cgcgtggcaa ctagggctgc gcgcgagctc ggggcgactg tggcggcccg gggagtgcag 4860
ggccggagag ggaagaggac gcgggctctg gccggggagg gagagcggtg cagggctggg 4920
ccggccagcc ggggcagcaa agtaaaggtg aacgccgggc tgggccaggc cggtgaacat 4980
agatcaggcc tgaggggagc gcggggcccg aagccaggcg tcccctcttg tctagcctgg 5040
tccctggagt cctagagagc ctcgccgcac cccctcccct tctccgtccc ctcctctcct 5100
cagagccggc tgagcctccc tccctgccct gcgcttccca cggggagaga aggaaaaaca 5160
ggagggggga ggaaggacca ggaaggggag agaggagtgg aggggtactg tttggagcgg 5220
tccgcgcgcc cccgcccctc gcgctctcgc gacgaaggct cctcgagccc agccgggtac 5280
aacaagtctg tcctccgacg tcagggggtc attaataacc aattaggagg gtcactgcgg 5340
ctcctataaa ggcgctgaga ttttgccaag gggaagacgg ccccggccga gtgtgcgaga 5400
ggctagcgcg cgcctgagcc ccttgctgcc gcttccctgc aaccacccgc ctctcaccca 5460
ccctgcaccc cccgcacccg cctccgcctc cacccgcgtc tctccaccct ccgcgccgcc 5520
tttgccatct ctacagattt caccatctct cttcccctct ccccctcgtt cgctttcctc 5580
ccagtcgccc cctcacctcc cgctccctcc tgcgtcctcc tcctctccgt cctccccctg 5640
ctctggttcc ttctccatcg cagcgctctc ctctcgcccc ttgggctccc ctctcgcccg 5700
cccacctccc ccgtcggccc ggccgtcccc cggcgccggg gagctccggg ccgcccatga 5760
tgggctccgt gctcccggct gaggccctgg tgctcaagac cgggctgaag gcgccgggac 5820
tggcgctggc cgaggttatc acctccgaca tcctgcacag cttcctgtac ggccgctggc 5880
gcaacgtgct cggggagcag ctcttcgagg acaagagcca ccacgccagc cccaagacag 5940
ccttcaccgc cgaggtgctg gcgcagtcct tctccggcgg tgagtccagc cgtcggagcc 6000
cggcgcaatc cctcctcccg gcgaccccca ttcccgtcct ggcgatgcgc gagacgcggc 6060
tgggataccc ggcctcgctg ctactcgcgc caacctgggc tctcccggcg ctcggtgcac 6120
ctcagtttcc ccatgggcca aaccaggacg cgagccacca agcagctccg cagcccaccc 6180
ggctcaagga ccgaccccgg cgaccccgtc gctcggcccc gacgcccccg ccggcccctc 6240
ccttcccctc ctgcgcttga gctggcgggt tcccggcatt tacagcctta ctaggcgtgt 6300
aatagcagtt gactcaaaaa gaaggggttt taaattcatt tagttaactt gggcttgacc 6360
cacgaaagtt cccacttaaa ccaagaactt taaaaggcag ccggggctgg ggagggggtg 6420
gagggagggc gggcggggag aaaaagccgc ggggagagcg agggagagaa agagagagcg 6480
agaaaagttt cttttcttta agatgtctca agttcttatt cctcattcat caacccgcaa 6540
acaatatctt tccctggctc tggcatctct gcgcgtcgcc ctcttttccc cctttacgat 6600
ttctgttcct ctcttaattt accgtgaaga ctaattccac ttccattcac gctatgtcaa 6660
ccatctaatc cccctttttt gtaaggggaa ttcctcggcc ccttttaaac aagtcccctc 6720
cgcattgagc tacaatttac tgctacagca ttcttccagg gctaatgaat ttagaattag 6780
caatttcttt cgaatggagc cgaatgaatg cgatcacttt aacagcgtga caaattgccc 6840
gccgcgccgc aatggacacc gtttaacccc cccctttcag ccggcccgct cgccgggtat 6900
tttcccaggt agcttagagg ggaaccttgt aagacatgga ggccgccctt gtgcgcctcg 6960
ccgcttccag ccctgccgca gatgcccgac aggggaaccc tcggggagct gggggccgcc 7020
gcggctcctc cccgcccaga gagatgacat cggggtttgt ctgagcccgg gcgccgccct 7080
ccctggcacc ccagggcctg ggagcagaga gggactcggg cgcgcccggg gtcacacagc 7140
gagcgcagag cctggccagc tgctgccggt gcttctttgg cacctccaac acctgccagc 7200
ccgaggtctg tccccagcgc tgatcacggc ccggctcctc tgccagtgcc cagagcctgg 7260
acacacagtg ggctcccgga agccgactag gcgaaagagt ctccggttgg ccttcacctc 7320
cttgcaggac ctggcctcag tttccctgtg cataaaaccg ctcgctgccg ttggctcatt 7380
aattcttaaa cttatccggg gcagaggatg gaagaagttg cgaatgcttt gagaattcgc 7440
ggagagacta aaaacccact tctaaaaatg atccccaacg caccactcgc tttccagggc 7500
acggagggtc tccaggttgc aaacagagga gaggtcgttg agcctccgca catccgactt 7560
cctccacacc cgggtggctt ctctggattt ggggccgact tgggtttggc tggtctgggc 7620
aggaccgaag ccggggtccc ggcggggaag gaagggccgg gcctcggctg cctcgggctc 7680
tgaccggttt tcctggcccc gccgccgcag aagtgcagaa gctgtccagc ctggtgctgc 7740
ctgcggaggt gatcatcgct cagagctcca tccctggcga gggcctcggc atcttctcca 7800
agacgtggat caaggcggga accgagatgg gccccttcac cggccgcgtg atcgccccgg 7860
agcacgtgga catctgcaag aacaacaacc tcatgtggga ggtacgcgcg ggctggggca 7920
gaggggcgca agggccggcg aggggcgctg gtcgcgggta ggactcgggc gtccggccgt 7980
cgccgcttcc acccgggctg agagcggcgg acactcctgg cctggacgcc ccctgagccg 8040
ggactctaag ccgcccgagc ctggagctca ccccgcctct aggctcctcc caacccgtgc 8100
cgaaaatccg accctccttc ccccggacac cctggcagag caagactgtg gttggctcca 8160
cttggcagat gagggcactg agacccagag cagtcaggtc gcttgcccag ggtccccacg 8220
cgccatccct ccaggcctct tcccagccac ttacattctt tccctggccc cggaagcagc 8280
ctgggaagcc cctcaaggcc agtcctgggc tgggggtgag gtggggctgg aaaggagaat 8340
gcctggtgaa agcagaatga cattcacgat gactgtggct gaggtggcat tgagtcagct 8400
tctgtgtccc cagcctgcag tcacggatga cctcagtagc ccatgcctta ctgttccctt 8460
ttcacggagg ctccaagagg cttccatcct aggcctttcc acccatcaca gtgccagtgc 8520
cagggagggc cacccctgtg cttcttccta actttgcaga acgggaaacc cactgaggcc 8580
agactggtgc acacccttcc taaactcatt ccctcgcccg ctcccccact ccagctcccc 8640
ccggcggacc ctggagaagc ccaacttgat agaactgcgg gatggcccag aggcctctct 8700
tgacctcatc tccctcctct ggagggctgg accactaacc accttctcca gttgctgggt 8760
caggaagttg gggtccagtt tgacctctga gtggccttgg cagctcccgt gaaggggttt 8820
aggccaagct ggagtgccac agtgacccag ccctccctcc ctggactcca ggatcctccc 8880
tctctgaggc ctggctgatg 8900
<210> SEQ ID NO 243
<211> LENGTH: 2600
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_00218 genomic DNA region
<400> SEQUENCE: 243
gatcttaggt agttgtcttg cactagcact tcaagtacaa agataccttt ggtgaatttt 60
caagaatgaa tataaaatca atttaagttc cagttttttt tttttaatga ctctcacaca 120
aatcaactgg ttataggcta cttcagcttc ttcctgaagc agttgtagct cctaattaat 180
gtgaactcca cgaagaaaga actcccacca ttttatgtgc tctgggatgc ggctgagtct 240
ttccaattgc agtctgttta ctctttggac agctgcatct cctccttatc tgctgaactg 300
aggactgtac aaatgtttct tgtgggtcag tgtaatatta aagaatagct atgtttagaa 360
ggccagttac cgttgctgta cccacacgtc aggggcaaag gctgagtggg cagatggggg 420
gctgccaccc ctcctcacgc ccggcttggg accagcctgg agtctcaagc cgaaacccct 480
cacgcgggtg ggcacacaat gcccggcgtg tcgcctgggc ctcctcggag gtgctttaac 540
aggctcttgc gcttttgaac ggccctcctg gactctgatc tgtttaaact agaggcgtta 600
ataagtgata acctggatct gccctccttg gaagctgcct gcctatattt tattgtttaa 660
aataaataaa aatggtgccc cgggagagaa gatggggttg tttccttttt cctctggctc 720
tgccccgaga aagagggcgg gatcctcacg gctcacagtg gggagggtct ttcgtcggcc 780
gccggctcgc ctcggagggc ctggaccact ggaccgccct tccccggggc cctgccgcgg 840
gaccgcgggc ttctggctcc tcctggggct gcgtccgtat gcgcggagcg tgtggccggg 900
ccgtcgccgc gccaccccac ctgagtccgc cggccagcgc ggggacgcac cgggcagcgt 960
gtgtttggcg accctcccgc acctctggtc tcagttgcgt gtgtgcacga ggggttccat 1020
agggcccagg gatgcttggt acccacgggg gagaatccct cgccgaaccc tgcgggtctg 1080
cggggcgggc cgcgagactg gcgcgcaaaa gcggctccaa ggcggggctc ccgcgctccc 1140
cggggccggc ttgccgagtc caagttgagc aaccggcgtc gagagagaca ccgcccctgc 1200
tgcgggcggg ggcctctcct cgcttccgat tggctgacgg ggggaaccta tcgccgtcgg 1260
ccgcctccgc cagagcggtt tgctggtttt cattcattgg ccccggagcc gcccctggat 1320
ttccatcttt tgtggcgcga aaataaccct ttgctccctc gttggttttg ttgaggttga 1380
ggggtgggac tgtgttcccc tctgctcgct ctcgtttttc ctgcccttta acagctcgcc 1440
cccagcccca acccccaagg aagaaagagg gaggtaacgc tgaggaaggg tggaaagcag 1500
ttctgcgtcc gtgggtggag cccgcccctt ggctgaccgc atggtgcccg cacggtccct 1560
tcccttcccc cagcgtccag cgcccggagg ttctggattt gcgccatgct cagcagctgg 1620
agtcacatct tcgtttccct gcccatttcc aacatcttag agttgatgcg tcctttttta 1680
cttaaaacaa ctacaaccaa ccatgttctc aggtaccaga acttttctgg gcttctagag 1740
aaatcgactc gccctgcccg ctcccttcct aaaccccttt gtggtccaca gggttgtttt 1800
aagcaaaatc aaacaacccc tccaaaaaaa gcaaacgaaa aattccgggt aaaatcaact 1860
atgctgagac cacgttttcg ttgaagctgc cctaagacca atgaagctga gaccgacctt 1920
caaggattaa cgatttctgt agctgaaatg ttctaatttc actgacgttt ggtggagacg 1980
gtgagaaaaa ataaatatga atttgacttg gaaaagcaca aaacaaacga aataataata 2040
tttaatttga ttaactgaga aggcaaacag ccacagtggt gtattctagg tactggtgtc 2100
tttggtgagt ttgtaattat ataaataaat tgctgttggt ttcatcaaaa atacagatca 2160
gaactctggc cgtgacaaaa aaggaaggaa gtataaattt gtttggtata tctaatttta 2220
taacagactt taccaacctt tcattatctg gagaaaagga aatgtaccag ttaacaatat 2280
aagttaattt gtttgcagat aattgttcat tttttgtctt gacaaaatac tctgtttggt 2340
taaaaacggt aaaatgataa ttcagtaaat atttaaaact ttgagagaat tggtttaaat 2400
cagggagttc aaagattttc tctgtgttgt ttactcttag tgatgttaca tcttgtgatg 2460
ttacatcttc ttctgagtgc ttttgaaaaa attattagtt ctgtgttagt ctctaaaaac 2520
taaagtaaca taaattgcca tgtaccaaaa ttttaaaaca aattttaaca actgaattgg 2580
ttagtaaaga aaaactactt 2600
<210> SEQ ID NO 244
<211> LENGTH: 6700
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_12535 genomic DNA region
<400> SEQUENCE: 244
tagcaagggc tctctttccc ctgcttcatg tgcatcctga aaccctaaca aagttagatg 60
tccatcagca taatcagtcc atgtgctgga tgtgtgaata tatgtcctcc aggtaacgga 120
ggaacttggg ttcagaaact agacagcctg agctcaccct gggctccact actctgccag 180
tgtagttgtt tatttattta ttgtggaaaa tatatacata acaaaaaatt acctttcaaa 240
tcgttttttg tttggttttt ttttgttttg ttttgttttg gagacagagt ctcactctgt 300
cgcccaagct ggagtgcagt ggcgcgatct tggctccctg caagctccac ctcccaggtt 360
cacaccattc tcctgcctca gcctcccgag tagctgggac tacaggcgcc tgccaccacg 420
cccagctaat tttttgtatt tttagtagag acagggtttc actgtgttag ccaggatggc 480
ctcgatctcc tgacctcgtg atctgcccgc cctggcctcc caaagtgctg ggattatagg 540
catgagccac tgcgcctgcc tcaaatcgtt tttaagtgca tggttcagtg gcataagtac 600
attcatacta ttgtgcaacc atcaccacca tctatctcca gaactttttg ctattccaca 660
ttgaaactct gtacccatca aataataact cccattccat cttctcctgg gccctggcaa 720
ttaccaccct actttctgtc tacatgaatt tgactattct aagtacctca tataagtggc 780
atcacagaac atttgtcttt ttgtgtctgg cttctttcac ttagcataag gtcttaaggt 840
tcatctgtgt tatagcacgt atcagaatat cctttatttt taaggctgaa taatattccg 900
tcgtaggtgt atactgtatc ttgtttatca atggacattc gggttgtttc caccttttgg 960
ctattgggaa taatgctgct atgaacattg atgtaaacat atctaatcaa gtccctgctt 1020
tcaattcttt tgtgtataca cccagaaatt gaattgctaa atcaaatggt aattctatgt 1080
tcaatttttg ggggaaccat acttgtatat ccttaaacct ctgtgtatca tagaacctct 1140
ctgaacctca tctgtaaaac acggataata acagcaatgc catttcaggg tggtctgaga 1200
attaatgcat atgaagcctt tggctcaaag actggacaca ttaataaatg ttcactaaat 1260
gtttgcttga tgtttaatct cttcatcctc tgaattgagg gactcatact aaaataattt 1320
ctaaagtcac tctcagctcc taaactccat gatcccatca ttaaattatt ttcctgttgg 1380
ggatgccagg agctctcaga ttgtatatta ggggaacacc ctcttcatga tccccgcaaa 1440
aatccacccg tgccaagaag gcccaatttt cctagctttc tcctaggaat ttgccaacat 1500
atcccagtgt aatctcacat ctcatttttc ttgccactcc ttctcccttg ctttctttcc 1560
atgtttcctt tctcggctgg cttttcctgc ccactgaata tctgcacttc aaattatctt 1620
ccctggttgc atttatgttc attccccaca agttaatgtc tgttggaagc aacacttgtg 1680
aagttctcca gattaagttt tcattcccaa gagtcccata ttttaaatga ggttttcctc 1740
ttcggcagaa tcacactggc agagctaccg caatttggtg aagtcagtgg agttgggttt 1800
ctcccctcat tctgtttatg ttgggttatc gcttggcctc atgtttggat tctcatcctc 1860
ccaacatgtg tcacatgcca gtgagaaaca acactctctg gtaccatccc agtggatgtt 1920
tacaattcag caaatactct ttttagaaaa gttaattaga ggaaatacgc ttccaagctt 1980
ttcttgcctg gggccagatt cagcatccca gcagggagtg gacttccttc actccttgag 2040
gaaatatttt ccttctccac gctattcctc cgtcttccct cgaaatgtga gtaaaacatt 2100
caacaactaa aatatccttg ctaaacacat gaagctgcgc tctggttcag gcagcagttt 2160
agctaccaac aaactgcgta tcctctctga agctttttca cagccaaagg taaaagaggt 2220
tctcgggtca gaaataaatg gatttttcag attctgggct aggaaaaaga gccagctcag 2280
gtttttttat tttcttttaa acttttatgg ctttgaagcg cctcacctgc catgtaataa 2340
aacaggaagc aggggaacgc tgatgtaacc ctgaggaatc aaatccactg agccctggca 2400
ctctgagaag aaccaggtcc tctggagctg gtccaccgac accatgcaaa ggcgaagatg 2460
aagtagggag gtgccttaat gcaaagtcac ccacttaccc ctaggcaagt gtttaggttt 2520
atggattgtc agcccttatg aagggctcct tcttccttta ttattgtctt tgggctgctc 2580
cagacaccat ggaggcaaaa ttcaaatgaa acactcacca tctttattgt aaatcattaa 2640
ggaagatcct acctgggcag gcaggctcta ggtagatgga aagtattgac caaaatgaag 2700
ggcagggggg tttgtgtatc tcagcttttc gttgatcatg aagggatgtg cctatggcta 2760
agtttccctt ctacacaggt tattgcattt agtatcctcc ccacccgacc tggcctgttt 2820
cattctcagg cacttgccag ctacttgcag cggcagagca cccagctctc agatagagtt 2880
caggtgacag gtaaccagca cagaagggaa gcagcgaagg ctcgtacata acctgcccct 2940
attcagagct gccccgtttg gtcatttctg tacatctcgg cctgccctca tctcatgagg 3000
tctcacttta ccccctgggc catagaagga cagatgttcc tatgacgttc ccacttcccc 3060
gcctgccagc aagcaggatc tgccatgtcc tcgcttctgc ccttagctgg atctccgtat 3120
catgtcccag cctcatttgt ccccagaagc ccatttgacc tggggattgt ggcttagaaa 3180
atgatatatg aaaaccaaag aagccagagc tctttcaaaa caaaccctat gcatcccaga 3240
aacaatctgc acttttaacc ttggcttttt cttctttctc actctcatca gaaaggaagt 3300
gtgtctatat atgctgagtg agtcaatctc ctgtgcttgg atctactccg aaggggtatg 3360
gctgtaggag ttcgtgaagc aagattcacc agaagaacac caagcaagcc ctgctcttta 3420
ttcctttctt tctttccctc tcttctttct ttcttgctca cctctgaggg agccctttcc 3480
aagagaaact tcgcttttgc aagtcagagc gggtaactca gaattgattc cctaaggcaa 3540
tttggtactt ttaaaatgat aaaaagagca aataaaatag gagctggtcc gctttcctga 3600
gacagtacag ccccacgatt tgggatgaca aaaccacgtc acagtctcag ggagggccac 3660
aggagctcca gcaccaccag ccaagtccct aaaattatca ctggaaaagc accacccccc 3720
ctcaacccct caccccaaac acacacagcc cacctcctga gactcccagt cctgctccca 3780
ggcagacccc aggaggaaaa tgctccctcc tagggtgtcc tcctagggtg tcccggacgc 3840
tactcacagt acctcttggc aaggacgaga tgagaaggag ctgaagaaaa gtgagcccca 3900
actgcgtcca gcaacccagc tccatccttg ccgcggctgg tgcccgagcg tctactgggg 3960
agggagagga gggacccagg gaggccgggg gcaggcgggt tttacaggga cctccccgag 4020
ccccagctga gcgggagctc gggtttcagc tcgccaggct ctcccatcct catctgaggg 4080
gaaccacctt cagccagagc gacgtcagcc caaacctctc ctctctgctg ccttaaccct 4140
tgcggggccc cgggaggtgt ggccacgcct ggagacccgc ggacggcggc tgcaaaggaa 4200
gctgcggggg agggaggcca gcctgggtac aggtggggtc ccagtgttgg gtgctgggag 4260
gaggggccat aggaccctgg gcgggagcag aggtacccag ggctgcgggg cgctcaggtg 4320
aggccgggag atcttcctac gggaggctga gacgggagct ggctttgccc tctctgactg 4380
cacgcgggga gcctgattaa aagcctggcc tgaggagaag gaggagttgg tgatgggagg 4440
agaaagggag cctccctcca ctccgcacgc aacactcctc gtttatctcc tttcctctcc 4500
gtttgctcca ggtgatcaca ggttggaaag cttattatct tttgcaacta caggctactg 4560
gaaaaagttt tcctcttcct atgatccccg tcatggtgaa ttcagcgaca taagcagctc 4620
ctgagctact ggaaaaagtt ttcctcttcc tgtgatcccc acgatggtga attcagcaac 4680
ataaatagct cctgcgcaca cgccaggcag ggatggcgaa gaacacacaa gaaccctcac 4740
tgcctccacc aaaagggctc agtttaggta caagatagca agtgacatct cgaaatgagg 4800
aagaaggatg tttcataata ggtgactttt taaaataaac tcctccgtgc caggtgtcat 4860
gtaccttaca tgtattaact caattattcc tcacaataaa cctagcctct gtattttaca 4920
attagagaaa cggaaccatt gaggattaca ataactcatc caaggccaca cagttagtga 4980
ggggcagagc cagggtttga acccgggcag cttaggccca caggctatag tcttagccac 5040
taggctatag agcttcttag gatgctacat atgcagaatt gtatttcacc atttgatatg 5100
gcttcgctgt gtccccaccc aaacctcatc ttgaattgtg gttcccataa accccacgtg 5160
tcatgggagg gaccaggtgg agataattga atcatgggga cagttacccc cataaaagtt 5220
ttaattttgt tctctagatg ttggcgggcc ctggtggttt acaagtaggg tgtgctgagc 5280
tcaaagcaaa gtctcgggaa gagaagtcac cctggactat tgatgaaggc ctggagtaag 5340
gattaagaaa tggaagtgga agggaaaaga taaggggaga aacctgagga aggtagaatc 5400
tgtaaagctc aggacagatc agaaggtcag gagccctgac acaggtgctc tactagaaag 5460
aatttctgaa ctccagccct gcttctgggg gcctattgca gtgaagtgac tggaagcaag 5520
aactcagcag gcctgtgttc taattttgtt gattcaccac tttctggctg tgtgacctta 5580
agcaagttaa ctctctgaat ctcagtcttc tcatctataa aatggaaata ataatcaaac 5640
ctactttgta gatcactgga agaatttaat aagattacgc atgtaaggcc catagcacag 5700
agcctaccac atattaagtg cacactaaat attaatcatt atctctatta tctgacctga 5760
gactgccccc aagaacatct catggtatga gtcttgttcc tacactcaac ttccatatcg 5820
agatgaaatc agttaaaata agcaccaaga gtagccttaa acaggagcag aataccagag 5880
ggcagcatat acctaagagg tagagggcag aggttcgaag aagggaggtt caccttgttg 5940
ctggccaacc agtcctggtc ctttggtgat gggagtggga agaagatgac ttagttccca 6000
aataactgta ggcataagag cctctcagga gtctgtttca actccagctg acggcacctg 6060
agctttacag attctacctt cctcaggttt ctccccttat cttttccctt ccacttccat 6120
ttcttaatct ttactccagg ccttcatcaa tagtccaggg tgacttctct tcccaagact 6180
ttgcttcgag ctcagcacac cttactccta aaccaccagg gcccaccaac atctagagaa 6240
caaaatgaaa acttttatgg gggtaactgt ccccatgatt caactatctc cacctggtcc 6300
ttcccatgac acgtggggtt tcttttcatc ttccctctcc ccacctccca gcccccacca 6360
cacacacctc tctgagtcaa taccaagcag cctcatccct acatgaattg catccccctg 6420
acagaatggg gctctaagtg atgaacctga aggatagcag tctataccac ccccaaatat 6480
gcccctttgg cataaggatt attttgagct gaaagcagtt aagaagaagt agatacaaga 6540
ataggtctct gttctccccc cattttccta aaagcagact tgaatttata aaagtatagt 6600
gtctccacct cccctctcta ccaggacgga cagaagttaa tcattggaga caaccctaga 6660
cccttatcag cccagaggaa tctacatacc aaaacttact 6700
<210> SEQ ID NO 245
<211> LENGTH: 1060
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_105474 genomic DNA region
<400> SEQUENCE: 245
gctcgccctt ttgctccccc aaggaaaaat aacaagcaaa cagaggtgct tgcccagtgt 60
ctctggaggg gcttccctta gaggtgggct gtgtgatccc ctgccaggag ggggcgatgg 120
gggccacttg ttcattaacg atgttaggct caaggtaact gaactttttt tgcacatgcc 180
tctctgcaga gagttgtgca taaacacact gctcggcagg acagagcaag attgggaact 240
gagggcaaat cccttcctcc gtgcgtcgaa ctcttgatcc caggccttaa aagtgggatc 300
tctgcactct gggctttctc tagcttcccc agggaaggga ggctcggggt gaggtgggca 360
cggggcatct ttcctgccca actgtgaagt cctaaaaagc ttcacaaagt ttctattgaa 420
tgacagcttt cttcttctct ttctccaggg ttgagttcca gaataaattc tacagcggga 480
ccggtttcaa gttcttaccc ttctccttcg agcatattcg ggaagggaag tttgaagagt 540
gagtccctgt gagggccgtg tgccccatgc taccctcccc gcctccctcc acagtgatca 600
gctgtgcctc tctgcctgtt ggttgtgatc tgtgggcacc agctcattcg tgtcaccctg 660
tctgtgagtc atttagatag aatagtcctc cttgggtctc ccaccacccc tagctttgtg 720
tgtagtgtag tgattttctg gctgtcactc atactcactg ggcaccagcc ttgccctctt 780
agcctccatc catccagaca gcccttccca cctcctggtg gtgagccagt ctgcattccc 840
acgccatccc aaagcccttt catcttcccc gtgcattgta gatggaagga gcacccatgc 900
cattcacatc tagactttga gttccctgca tctgccaccg tagtttctag caggagtagt 960
ggggggagta atacagattc ttccctagaa ggggacactg gtaacatgtc ccactcttgg 1020
attagcaggg gtgggtccag gaagatgata tttgcgtctt 1060
<210> SEQ ID NO 246
<211> LENGTH: 2800
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_74707 genomic DNA region
<400> SEQUENCE: 246
tttctggtga gcagaatttt gaggtctgtt cctttcactt cttggtattt cggttgtttc 60
tgtaatgact gtatcttgct tttgtaatca taaaggacag taaaggaaac ttcattttga 120
aaataataca aagggattcg gggacttcaa aagaaggtga ctctcctcgt ccactccaga 180
gaatcaggaa aggagtgttt aaagacccac agaattccta caagtgacgt tggggggggg 240
ccagccagcc agggcgcatg ccggccagcg agtggggtgg gctctgggtc cgggagaagt 300
cagatcagtg ctctgtacag ggccttgagg gcaagacgag gaatttcgac ttaggtcctt 360
gaatctggag agctacagaa agtttgtgag ctcaggagaa gcgctccgag ctcggcatct 420
ggagcagttc aaggcagcag cgagcaagtc caaagacgca ggagggaggg tggggtggag 480
gagtagagag aaaacagaag ccgtctacag accctttttc cctctggggc aactaaacct 540
caagtgcagg aagcgcttgg ggactgccca gccctcagct gtgttattat tcggtgatag 600
gtatttgcta attacttcca aaagcctccc atctgtcatc ccacccagac tgcgcgcttc 660
taattcctcc taccccacat gctgtgccca atgaaaagta tggtcagcga gcgaaggttt 720
gcaaggagac agacgagggc gaaattaagc caggcggctt ccctttaaat cctcgcaaag 780
cagaagggcc cctcactctg gcagcaggcc ttggccaagg ggcctttagc cctgacgacc 840
cggggaagag tctcccaaag cagaacgccc ggtccggcgc ccagaccaaa cgcgggggaa 900
ccggaagggc gaggcctcca cgtaagtccg cggtaaaagt ggcagggagt ggctgcctgc 960
aaagacccca agacggcttg aagaaggagt gggtggcggg tgggggttag ggcgactagg 1020
cggggaaaca gggagagggt cgggctccgc ggggcagctg gggccggggc tcgccgacct 1080
gggcgggggc ggggggcggg gggggtgcgg cccgggcggg gccggtgggg cgggaggcgt 1140
ggccggcggg gggagtgggg gcggcttttc ccggcacatg cgcaccgcag cgggtcgcgc 1200
gccctaagga gtggcacttt ttaaaagtgc agccggagac cagcctacag ccgcctgcat 1260
ctgtatccag cgccaggtcc cgccagtccc agctgcgcgc gccccccagt cccgcacccg 1320
ttcggcccag gctaagttag ccctcaccat gccggtcaaa ggaggcacca agtgcatcaa 1380
atacctgctg ttcggattta acttcatctt ctgggtgagt gagcgcgact gccgcgcgct 1440
cctctcaggg cccacctgtt cgcgggcccc ggacactggc cgcggccgcg agtgccggca 1500
gctggcactg cccgcaccgg gcaggcaccg ggcgggaaga gagagcgccc tgcggctgcc 1560
agctggctcc aaggccgggt ccagagccgg gcgggacggc cgcgacgggc gcattcgggt 1620
gggggctcat caccgcccag ccggcgtggg gagccgggcc ctcttgagat gaggcgtgcg 1680
ggagggtcct gagcacttta gctcgcctag gatttgagct ggggtgtgtg tctgctccca 1740
gctcaagtcc ctccgagtgc cagagaggaa ggcagggaga agcggagcac ccctctttgg 1800
gccaaggcca aggaggactg tggtgagcag tatggcttgt gaccgggtgg ggtctcccag 1860
gtagtagggg gcgccaggaa gggagggtgc gggcacggcg agagctcagc caagagcggc 1920
tctcactttt acgcaggagc ggcaggggtg cctcggccgc gggtccggcc ccgggaccca 1980
gtccctgaga gtcgggggcc cctccaccct tgaggaggaa cctcgcaggc ccccgttccc 2040
tcagactttg attctgagcc accgtgagag cgccgaactc cctggtagct ccctgaaaga 2100
ctagcttgtc ttgatttctt tcaaggacga taagtatctt cactggagag aactcagagt 2160
tcgggagagg agggggcaga tacctatctg cgcctctagt gggatgagtc ctgtgtgtgc 2220
atttccggga gagatcaggt gccagccagc tgcccgccca ggagagcctt ggccttgccc 2280
tctcccctcc ccgccagccc aggcggccca cccaaggcca ggcagggcgc agagcggacg 2340
ttcatctgga gaggccagcg gggccaggag ctccagagac acctgctgca ggccactcag 2400
cctctacaaa tgggaaggct gagaggcgac agaagcaagg aataggaaac ccttgtgtcc 2460
ttgtttctat agccacattc cctgcacaca catgacaata cttgccgctc tgcaggcagg 2520
aagagagtct ctatgccact ctcaagatag atggatgtag aaacaggtgc atgccaccag 2580
agtcttgtaa caaaaaagtg cacttggcca ggcacagtgg ctcatgcctg taatcccagc 2640
actttgggag gctgaggcag gaggatcgct ttcatccagg ttcaagacca gcctgggtaa 2700
catagtgaga cccccatctc cacaaaaaaa taaaaaatta gctgggcgtg ttggcatgca 2760
cctgtgatcg cagctactca ggaggctgag atgagaggat 2800
<210> SEQ ID NO 247
<211> LENGTH: 1060
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_93325 genomic DNA region
<400> SEQUENCE: 247
ctgaagacgt tccgggccag ggggggcctc tccttggcct ctgctttggc caatcctggc 60
ctggtcccct ggggtctctg gcccaagtca ggggcaccca acacagtgca gatgaattcc 120
aggtccagcc aagccaggta ccaaagcaag aaagtgagga gtttggggag tctcatcctc 180
tggccagccg ctgaatgaca ccaaagagaa cagcggcagc agcaaaggtg cctctggttt 240
ggcaggaaaa accatgaaag gagtggactt tcaaaagcag cggcagcagc agtagcagca 300
gaaggaaagg ctttctcctc agtctgagac tcttgaagtc tgccgggtgt gtgtttgtat 360
ccagtcccat agtggaaatg ctctcgtatc cagacgtgca ccgtctccag tcagcagctg 420
aaaataactc gttcttgaaa ggagaaagcc aaccgccccc tttctcctgc acaactgact 480
gagggcttga aggaggcttg tataaggctg agggattttt ccaagaagga agaatggcgt 540
aatgctgcct gtgtgctcca gttttttttt ccccctagtt ttgaatcctt tccagtgaaa 600
atacttcaca cacacacaca cacacacaca cacacacaca cacacacaca ctcacaggcc 660
tgcaggtgct cagaaaaatc ttttacaaac ctgaactcag gaattggaaa cggaattcca 720
acccaaacca atttaattac tctctgatgt catgctgtct aaactcattt aagtgcgata 780
tatttatgtg aaaaaaatca ccgctgccct ttcgaggcca tggctcacgg gggctcctgg 840
cacagagccc tgcagcggga ctctaggctt agggggcctc cccctccacg gggcagactc 900
aggggtcttc acctccacct catggagcag cccaccccac tttcccgagg agagatgctg 960
aagaatgagc tcaaagatct taagccccag aagcatgggg agtgtgggtt tgtagttaag 1020
ttcttagagt gtttttaaag cagtttcaac tcctgcatct 1060
<210> SEQ ID NO 248
<211> LENGTH: 1060
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_101161 genomic DNA region
<400> SEQUENCE: 248
gcagattgct tgagcccaga aatttgagac cagcctgggc aacatagcga gaccccgggc 60
aacatagcga gaccccatct ctaaaaaaat aaaataaaat tagccaggtt ggtggcacaa 120
gtctgcaatt ctaactactt ggatgggctg agatgggagg atcacttgag cctgggaggt 180
caaggctgca gtgagctgtg attgtgccac tgcactccag ccgaggggac agagtgaaac 240
cttgccttaa aaagactgct atggcccgag tccctctgct gtgccgggca ctgtgctggg 300
catgtaacag gcatattctt ctgatcttta caactctccc atgaggcagg cactatcgtt 360
agcccatttt acagatgtgg ccatagaggc ccagagagga gaaggggctt acctaaggct 420
atagactgtt ggtatctgga gataaacccg ggatggtgct cactaaacta ccttgggtgt 480
cagtcctgct tcaagactcc agagagataa agagagatga cctcagagac aaagagactc 540
agacccagcc agaggcccaa tggacagtgg gaggggtggg tggaagaagg ctggtctctg 600
tctgaccaag cccccccaga ataacgcagg ctgcccccct aggtggaaac aatgacacaa 660
tcagctccca ataccaaggg cctgacatca caaggggagg ggaaggcagc tgaggttgtg 720
gggggaggtg ccccgcccct tggcaggccc ctacagccaa tggaacggcc ctggaagaga 780
cccgggtcgc ctccggagct tcaaaaacat gtgaggaggg aagagtgtgc agacggaact 840
tcagccgctg cctctgttct cagcgtcagt gccgccactg cccccgccag agcccaccgg 900
ccagcatgtc ctctgctcac ttcaaccgag gccctgccta cgggctgtca gccgaggtta 960
agaacaaggt agggctggag ggcctccctg gcctggccca cacgtcctgc caggccagag 1020
ccctgagctt ggggtccctt gaaccccctc ctgcctatcc 1060
<210> SEQ ID NO 249
<211> LENGTH: 1060
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_101251 genomic DNA region
<400> SEQUENCE: 249
atggagcgtc gtcatggcaa ctggctcccc cgtagcattg gctgccagga gggaggggag 60
gaaatgggag ggggagggac agacagggac cggcacacac ttgcagcggg ggtggggggg 120
cagggcccac gggtgcctgg cccggacacc gctgtgacat gccaccagca tggacacatg 180
tgctacacgc taagatgcag atgtcaggca cgcgcagccc acacacagct gacacacgtc 240
gcagggaccc tcatagacaa gcgcatcaca tacaaaggtg gacagccatc agcagacggg 300
gacacgtaca cgtcacacac aaagacgcag ggaccgcact ggaaacgcac aggcaggcca 360
gcttccagca cagatgcacc cggccacgca ggaacgtcaa agcatcacaa agacccacac 420
atgccccgga caaagtaaag ccccagatcc acagacgcac acgccacaga caaagatccc 480
cacggacacc actgtgacat gctgacactc atagtcacag ccacgcagac agtccctaga 540
caaatgggca acaaagaata cccacagaca caagtatcac atacatgcac gtcacacaga 600
catgcacaga cagcaattgc acagacacac gcagacacac acatcacatg aactaacata 660
gacacggaca cagcagctac acagagacag gcacatcaca tacatgagta cacagaaaca 720
taatacatgc atgtatacgg acacgtaaca tgcatcactc acacggacac aagcttcact 780
cacatggata cacacagaca cactacatac acatgcatgc gggcacacac aactcataca 840
tacagggcta cataaatcac atgcaaaaat acacataaat acaccacaca ctgatacata 900
cagacacata taacatgcac atatacacag tcacacatac ataagcacag acataggcac 960
acagatcaaa tacacagaca cacagagttg cacacatcac atacctaaac agacatggac 1020
acacacatca caaatacaca cacctttcac acaaggttac 1060
<210> SEQ ID NO 250
<211> LENGTH: 1060
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_69214 genomic DNA region
<400> SEQUENCE: 250
cctctcttga gtcgagggct gaatctttct cctctaagca gtctggtcag gaaccttggt 60
ttcttgagag gcccccaaga tgccgcagct ccagggctct tcctcctcac cagaaatccc 120
tgggcttcca caatgtgaac tcactcattg tcaggtgtcc gtggagtgtt tttggcatgg 180
tgacctgtct gggcccagca tgttgcagat gtgtatttat gcgcaatggt atgcatatct 240
ctgtgtgact gtcagtgttg caagctggct ggatccaacc atctcttctg aaataatgca 300
tccaaagggt tgatattctg ggggaggtca ctgcagaagg atggaactga cctttattcc 360
ccagtgggca gttactgagc tttcctcctc agagccatgc tggcagccct gggacagaga 420
acggtgtggc tttggctgcc tctgcatgga atcttgcccc ggactcctga agactgcaca 480
aggaatgagg aagatcaggg acaacctggg aactgaataa ctttcaaagc cagtgctcag 540
cttctctgct ccgtactagc gtttacaggt cttaattcaa accagatgcc tgtactagtt 600
tttagacccc aagtcaacct ttctgagcca cagcttcccg ctgggaataa tgatgcctgc 660
cctatctacc tcacagactt gttatgagga taaagtgaga ttaaactgcc tcaaagtgct 720
ttgtaaacct caggtgaata ggaaagggga aagtaaggct ggagtgatga tggggaggtc 780
ggaggataag ggggggctgg gattgctaat ggggactaaa atggccagtc tcctggcaag 840
attttgagca ggtcatttca ttgaggcctc ttagatttca tatttgagaa ttagggcact 900
gattcctgac tggctaggca tggtggtcac tggcttgagt cagaccagga atgtctctta 960
gaaatggtca ctgataggca tccttctcct ccagtcagga ggggctggtt tccttatctg 1020
ttgcagtctc gactgccaga gggaggcgag cgtggtaggc 1060
<210> SEQ ID NO 251
<211> LENGTH: 2500
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_88517 genomic DNA region
<400> SEQUENCE: 251
ctacttggga agaaggaggg tcaggtccct tccagccagg gctgtggtca aggtgctgag 60
tcactagggg cagtggggag ggggtgggag acagctttgc ctccctctgg agttggggca 120
tgagggggcc aggacagagc cgagcacagc ggtgaacggt ggagaaaggg ctcagggccg 180
tggctggtgc ccatggtggc cgcagggcca cccatggccc catgggaggg tgactctgag 240
cagcccttac caactgtagg actctgctgc cctggagtgg ggcctgaaga actctggggg 300
cggcactaga gtcaggagtg aggggccctt gcgtttccag gctccccttc cccagtcagc 360
ccagcctgga gctgccacag agtggggtga ccgctgctgt gattgtcgcc agccccccgc 420
caacaccaga cacacaaatg gggtgggctg aggggtggga ggcagcaggg gcagtgacac 480
tggagcaggg acaagaggag acatggagag acagaacagg tcacacaagg gcagaaaggt 540
caagagaaaa cagcagggcc agagagaggg gaagagaccc agaaacagcg gcggggcccg 600
aacaaccccg gagggtgaga ctaacagaga ctcgggtagg gagacaccgc gagcagagcc 660
cgcgcccact cacgtcctgg aagagcgtgt gtccggcggg ccccgggtcg ggcgcgagct 720
gggggtgccg cggggtctgg ggctggggct ggggcgcggg cggccggagc aggcacacgg 780
tgagcagccc cgcgcacgcc atggcgccgc cacccgctcg ggctcggctg cggttgctgc 840
cgaccctgga cgccgcggcg gactcggtgt ggctagaggc cgccccttgg cgccggcgcc 900
gacgcgcggg ctcaggcccc gcccccgccc cgcccccgcg gacgccgggt tccctcgcct 960
caaggtccaa ctccagcgcc gcgggcctcc gcgcttccgc ggccacggcg gagggggagg 1020
cgcccgaggg ctccggtccc gcgacggcct gtcgggagca gaacctaggg gctgcgggcc 1080
tacccagagg gacaggatga ccaagccagt gccgaggtca gggtgacaca agtgggtaaa 1140
acccaccagg acttcacctt ttggggcgtc tgtatcctca tctacaaaaa tggtactggc 1200
agacacccta tgcaattgtt gggactcatt caatgtcaag tgcttacaac gggggctggc 1260
gcagaggaag cccacaggtc cgtgcggccg aatcccaggc atcccgacgc ccgccctctc 1320
tggcactaag cgcagccctt tcccctcccc tccgtgactc tggccctccc ttcaacccgt 1380
tctccacaca gcagccgggg ggagctttta agatgcgaaa gaggaggtgt cacttcggtc 1440
tccagtgact ccttggcccc tgaataaagc ttaagactga acgccccact ccaggagcac 1500
cactctgacc ctcacctcag gaccgcagcc acactgcttt ctctccggtc ctctatcccg 1560
ctccctcctg cccaaggcct ttgcccatcg tgtcctctgc ttggtgtttt cttcctctgg 1620
ttaactccta cttattttac agcgctcagc ttaagcacca cccattccag aacgcctttc 1680
ccgattttct catttatgca gatctcctct ttcagaccct gagagcacca tgaaaggagg 1740
taacacccgt gtccccagaa ctgttaaata cctgacacag aaccagccca ctgtatttgt 1800
tacatgttta ctaatgtcca gaaacgtctg gaaggaagac agcaaactga gcagagtggc 1860
ctctggggct ggggaaagga gaggccactc attactctgc acttcgggca gcactgaata 1920
gcattcttgg ctttctacaa caaaaacctt tactggatct gcttttgagt taggaccaaa 1980
acagcgagga agctgacctt tcttcgagtt atgaggctca aatcaaatcg ggcacggaca 2040
gggagaaggg aagtggagaa tgggcatttc cccagcaacc ttggcctctc ccgccccgaa 2100
atgttcccaa cagagtccca aaacccggcc caaacgtcat caaaatattt attaaaacca 2160
aagcaggagg gaacagagct gttaggaagc aaatcaaagt gcagattgga gggtggggca 2220
gagcagtggg gaggcaggcg cttcagacac tgcaggaggg accacagggt ctgggctggg 2280
ggaggccttc accacccctc ctgcccacat cagtgaaggt cccccactca cctctcccat 2340
ctcatatcca tcctgggggg cagctggggc cctgaactgg ccccctggag agggcccacc 2400
ccaccatctg accacccatg gctgtcagtc agtctgtctc cctccctcac tttcccaata 2460
aataaatcac ccaggcctca gttccttcag tatggggcag 2500
<210> SEQ ID NO 252
<211> LENGTH: 5600
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_103824 genomic DNA region
<400> SEQUENCE: 252
agccaaggtg ctcccctgtg gaggaggcag gacacaagcc tgtaggggtg tgtgcagcag 60
aaccttttat caaacttgtg tcccactctg caaggcaata ataatggcta attcagctat 120
tatataaaaa acgtatctca agtactgagc actaagtgtc aggtactaag tgctttgcgt 180
acattgattc atttaatcct caaggtgacc gaaaagcata ggtatttttt tttttttttt 240
tttttttttg agacagagtc tcgctctgtc gcccaggccg gaatgcagtg gcactatctc 300
ggctcactgc aacctctgcc tcccgagatt ctcctgcctc agcctcctga gtagctggga 360
ttacaggcat gcaccaccac gcccggctaa tttttgtatt tttagcagag acgaggtttc 420
accatgttgg tcaggctggt ctcgaactcc tgaccttgtg atccgcccgc ctgggcctcc 480
caaagtgctg ggattattac aggtgtgagc caccgcgcct ggtcagtact cttatttatg 540
cctttttttc ttgaggcaca gagaggttaa atagcttggc taaggacaca cagtcagtac 600
ataatggagt ctgacgctag gacctgcccg cctgacgact acatagaacc tgtacaagga 660
aaggccggag gagggagtat aaacagggcc tggcttccct gaggagtgat ctttcgactg 720
gaaattagaa aaggaaagca gcttcttgag ggtgtggggc tggagagaac atttgtgtgt 780
gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt ctgtgcgcgc 840
agaagctgaa agatgggaag tagtgagtgt tcaggggctt ctgactggag ggcagccttg 900
gggaaggtct ccgcagcctt aaccggctgc tatgctgggg atgtttgatg cccatctggg 960
ccccggcttt cttattctca gaggcccttc ccacatcttt aggcaagtcc attaaatcct 1020
ccgcgtgcca cattaaaata caagggcaag tacaactctg agtgcagttg caacagaatc 1080
gtttgcacaa tgtcgcatgt cttaaacatt caatcaaaca tcgattactt ccaattttgc 1140
agttttcttt gcccctgtta gcgccaacag attttttttt ccagatctca gacatttatt 1200
ttaataggcc cctgacaaag tcataagact cagagagaag ggagagtggg agaggtgtat 1260
aggaaggttt tgtgccaggg actagtcgct caagaattag gagacgccct gggcactgga 1320
aactacgcag cgcgaagtag ggacagcgcc tgtgttgtgt agtggaccag aggttgctga 1380
tacctgggac atagactggg tgggcacggg aagtaaagcc tcgggacttt ggttaagcgc 1440
gccccactgg cgtatcgcgc cgcgggactg cagagccgtg agcagcggtc gccttggtgc 1500
agggttccag ccacatcttc ctcgcccagc cagcaccctc tgccgttgac ccgcctctgc 1560
gcccggcaag cggcttccag cagggggcgc gcgcggacca ggcttgggcc ctagaacagc 1620
gcggatggag tcgctggagc aagtccccag atccaaccgg tttcaaccct ccccaccctc 1680
ccgacgctcc gggttcgcga cgttgaagtt aagggtcgat ccgcagaaag cggccagggg 1740
ctccagctct ccattcctgg gtctgtctgg ggtcggctcc agcctggtta gaagccttag 1800
tctggattcg gcagattctg aatctgggac cctctgcgct agcggcttgg aaccttgtca 1860
ccctcccctc ccccacccct acttccacac acctgattag ttgtctgttt ctttaatgat 1920
caaagacgtg ggcggcggcg ggatgaggtc ttggttcccg gctccacagc cctccctaac 1980
tgtcattatt aacgttataa acattagacc cgcttctgcg cgccggacgg cgccggacga 2040
ggtgcgcgca gtcttctagc tgagctcgga ggcagatcca gaagtcgcgg ctcccacccc 2100
aggcctcggc ggactctgcc tggggcgact cgggctccag ccctgcccgg gcgggcactg 2160
ggctctccag ggtcgaaggc aggggtaagg ggcgtctttc ccccagggca gcctccggga 2220
acaaaagcat ttgctgtaga gtgagctaga gcctccgggc ccgcgggagt cagctcccgc 2280
ccaggggtgg tcaccgcgtc cttaaccacc ccaggagccc cgtctccctg ccgaactcct 2340
tggcttctgc aaccctgtca agacagcaag gaaagggggt cttccctggt cctcgggccc 2400
cgaagtttcg gggttgctta taggacgggt tcctgcagtc cagggaagct ctgggcagat 2460
agcgagccca ttctcccttc cattacccag attctgcctc cctgcggaag gcaaaaaaga 2520
aagaaagaaa ataggtaaaa accggcggag ggccttgagc ctccccgcct ggcgcccctc 2580
actcagtccc gaaaagtccc ctggacacgc catgccggac cggactcagc tcccgctgct 2640
gggcccctgc ctccaaatat ccttcccagg cacaggctcc caagaccgcc ccctcagggt 2700
tcccaacacc cggacaactg cccaagacgc cgctccccgc ccccaccccc accttgttcg 2760
gcagacaaag aagggtgtgc tggccccgcc gtctgcctcc ttctcccgac cccacaaggc 2820
ctagaaacct cagggactca ccccgggcta gggacccaat cctggctgtc ccaccacagg 2880
atccccggca gggacgggtc acagtgctct cacccctcga ccattttcga agacaccttc 2940
cctgaaaggc gccttgcgcc ctccccatgg gtcggcgggg ggggactcca ggcccgagca 3000
ggcggtgtga agttctgtgt tctgaactgg ggctgagcaa gatgcgatgg tctcagcccg 3060
ctgggccgcc cgtagcgacg gcaggagtag gggagaggga gggacgcttg gagtgtgagc 3120
gcaccagtct gttcatattt aatttacaaa gcagcctcgg aaccccgggc cgggtggtct 3180
ctttagacgc tgcgctctta gcctgtctct cttccccacc ccctccccta gctcattaag 3240
atgctcaaca ctcaaatcgg ggtattgatc tccacggaag ccccaaaccc tcgccatcga 3300
gagaccccca tggcccgggg tgatggctgt ggggcttggt gctcccagag agctcagtgg 3360
ctacagaatg ggtggggatt ctgcgtgtct cccggagcct gaaccccttt cctggttatg 3420
gccggtagct gtctccaggg ctaacgtggg cagcgcaggg gggcggaaac cgggttttag 3480
ccaaatgcct cgacatcgcc gcgcctccgc ctcctcgtcg ctgaaagaaa tgtcggggtt 3540
tcatcagagc tagggagcga cagtcgggaa cagcgagtct gccgaagccg gctgttgtgt 3600
gagggtgtga gacggcgggg cggtgagggg ccaccgcggc ttgggggata gtgcgtgtgg 3660
ggttgaccgt gtgtctgctt gagaggctgt gaagatatgg ggggcagata tgggagaaat 3720
gctcgggcct gaagtcccca gcccaccgtg ctcaagagta gcggacgttt tgccaccatc 3780
cttgtctgtg ctactgtctg ctgcagcttc cgtgccccgt tctcctggag caggcaagac 3840
ctggagtgag gtgcttgggt gcgctcgaga gagcttcccc ctgctccacc tgtcccgcgg 3900
tgcgcgcagg ccaacgcgtc gggcagtggg cttcaagcgc tggtttagcc acaaaagacc 3960
agaagtaaag agttccggct taagaggctg ggcagggctg cggtgggctg gggagggggg 4020
tgtcccttcc cagcacgccc tgcagggctg tgcgttctgg tgtcgggtta gactagcagg 4080
cggggcgggg gggttggggc ggcggggcgg gggagactag ggcttatatc agcccagatc 4140
caggcaaaaa tggtagggag ggtgcggcgc tctgctaaca ctatcaatta tgcatcatgt 4200
tgaacgtggc ttcggggagg aggcggctag cagcgggggg tgcgggaggg aagggtccgc 4260
gcgagctcgg ctgcgcgcag ctcagcgggt cccgctcgaa gtctgtcggt gccaccgcct 4320
gcatttgcaa aaagagttta aaggcaaaga cacgccttcc ccccccactt cagccgcgcg 4380
cctttccttc ccccaaattc ctcaaagatg gtttgtctca cgtgttgcag ggcgtaaaag 4440
cggcttgcat tcaattagca gcgaagctcg cgggcgctgg cgggacaggc gcgtgagggt 4500
gagttcgcgt gaatgtgtgt atgcgtgtgc gagaggagaa cggtaagtgt cccgggtgca 4560
ggtgtgcccg tgaaaatgcg tgtgaatgta gcaggggctg aacacattga tgcgattatt 4620
acctgaccat ggatgattgt aaactgtgaa ggtcggctat ggggagggtg tgagggactg 4680
tgtgcgcgaa tgtgtttgaa cgtggggtgg gggaggtggt gtgatcaggg acagtaacaa 4740
tgccagcggc tgtgtaaatg tgggggtacg tgggttatgg gggtgcagta ggctgcgaag 4800
agcccagcca ggacagtggg cgtgggatgc cccttatgac cgacgtgtct tggccttggg 4860
gagggtctcc gtggctttaa caaaagtaga ccaagcagga ggcgggagag gctatgcgcg 4920
tccccgccag gcccgggagt gcgcaaggac tttctccaac ctgcagccag agaggtgggg 4980
gaaacggacg caaaaggaaa aattgaagtg gtactttggg gccaccaagt ccccaaactt 5040
acctgtccct ttctttgccc cccgcccccc gttttcccca cagccacaac acatgcgtgt 5100
atcttgcttg ggctatcttc cctgctctgc cacgccgggt ctggagaagg ggtttcagcc 5160
ccaggacatt tactgagagt cggcgaatat tgggtaagca atgggggcca ccccacaacc 5220
ttgacccagg tggggttagg tccagcctag ggcacctgat ggggtgcggg gctggtgggg 5280
gtgctgtctg gcaggaaccg ggaagggagg gaagggaccc tcccagaaga gcaaaggcag 5340
agtgaaggag caggttccca aagacaagtt gtgggagggg ctctgccaaa cctgacaggc 5400
gctccaaatg ggggcaggga gtctgtgcaa gttcgtttgt gtgaccgggc ttaaggtgtt 5460
atggggaggg ggtccttagg caccgcagag ctgtggagaa aggcgcagaa tctttcatct 5520
tctccagctt cattagctag tggcagcccc atgacctgtt ggctgaggac gcctctgccc 5580
aatgggagcc gcctgaggga 5600
<210> SEQ ID NO 253
<211> LENGTH: 1060
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_108445 genomic DNA region
<400> SEQUENCE: 253
ccccatctct actaaaaaat ataaaaaatt agccaggcgt ggtggcaggc gcctgtaggc 60
ccagctactg gggaggctga ggcaggagaa tggcgtgaac ccgggaggcg gagcttgcag 120
tgagctgaga ttgcgccact gcactccagc ctgggtgaca gagcgagact ccatctcaaa 180
aaaaataaat aaaataaaaa ataaataaat aaataatatt ccactcagaa cagcccctgc 240
taacatttgg tgaacaactt gttcaccagt tggtaggcac ttactcagcg ccaggcctgg 300
tgccaagctc tttatcagct gcgaagcatt catcttattt actgctcaca ggggatccta 360
ctgctagccc caaattacag actgggaaag taaggcctga acatctggga cgcaaacaca 420
gtctgcttca ctgagtctct actacaagcc ttctgtgggg gctcccaggg gaatggctgg 480
cccagtccga ggggacctca gtgttcttgg cacatggtag gcatctgtct ttgttgggca 540
gttgcatcag aagggttaag gacagctggg aacacatcct gcctctagtg aacctcgtgg 600
ttctgtcatc tgcctgcccc tcacccagcc taacccctct gaaccaggag cctgagctgc 660
acttactgct cccccctgcc ccccggacgg cctggaccaa gcagcagctc ccagagcggt 720
ggcccagcaa acacgacttg actcgaggcc aaggctcttg agggctgagc agtgtcccca 780
tgcacactcc tgaaacactt tgtcccttcg ccattcagaa ggcatcattt tggggaaggc 840
agcagccggt ttttcagagc cagcgagtgg ccctgccagc tgctgagcag ggcaagctga 900
gaagggtggt ggtgtgcaag tgttattctc tctttttgtt tttgtttttg ttttttgaga 960
tggagtctta ctctgtcgtc caggctggag tgagtgccgt ggcatgatct cggctcactg 1020
caacctccgc ctcctgggtt caagcgattc tcctgcctca 1060
<210> SEQ ID NO 254
<211> LENGTH: 3600
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1g_02210 genomic DNA region
<400> SEQUENCE: 254
cccccgaggg tgtgtgtgtg tgtgtctgtg ttgtggggtg tattcagcag catatgcgct 60
gtgtaatttc tgaccttccc tctccctgtc agttgcccct tcttcctttg attgtggcta 120
atgaagaata ataaatccag gggcagggtt tgccagtgga tccttccaag actcaactcg 180
aactgtactg gatacaggga ggaggaggaa gagaaaaggg gggcaagagg agcgtgtgtg 240
tgtgcctgtg tgtatgtgtg tgtgtgttgt gggaggggtg gggacagcgg ggagggggag 300
gagtcgcatg cgcacagacg acccgagcct gctccgcggc tgtccaatcc gctgagagct 360
gcgagaaatc gagtgagaga aagccctgca gcccctccga ccccatgtct ctttggcacc 420
aggcacccgc cgggccgtgg ggggctcgta gccgaacgcc gacctccgct cgtattgggc 480
tgggagttca gagccgcgcg cagaacccgg gttggccgca acgtctgtgt tctcagcggt 540
ggccgggaac ctgggatcag ggtcacctga gctgacgggg tgggggcggg ccgagtgggg 600
ttggaagcct ggaacttagt ggtaagcagg aggcgtagga ggtggcagcc aggtaagagg 660
cactcttacc tacccaacgc tggcttgggc cgcaacttta tttgggagtt tctttttccg 720
gtgagacaga gacccggcag aagaagcggg aggggctgga ggctggtcct taggtaggca 780
ctgcccggcg actggagcgc ggacctggcc atttgggtgg ggttgagtgg gggcgcgatt 840
gtgagtagca gccgcgggac gctgcgaagg ggcggcggca acagagcacg ggcgggggca 900
gaaaagaggc ggcggagggc gcggtggggg agcgcgaggc gagtgctgag agagcagaaa 960
ggactcaagc ctgaggggag tagagaggaa gaaggggcaa cgcgagaaac cgaacaggag 1020
ccggcgtttc ctggcaaggg agggcggagg cgcgcgggag agagggagag agggagggcg 1080
gggggcgcgg gggtaggcgc ggggagaggg gagtataact cgccggccgc gaggagcggg 1140
ggcagtttcg ggtgccgagg tctgcagcta gcggcaagcg gagtcaggca tccgttcaga 1200
ctgacagcag aggcggcgaa ggagcgcgta gccgagatca ggcgtacaga gtccggaggc 1260
ggcggcgggt gagctcaact tcgcacagcc cttcccagct ccagccccgg ctggcccggc 1320
acttctcgga gggtcccggc agccgggacc agtgagtgcc tctacggacc agcgccccgg 1380
cgggcgggaa gatgatgatg atgtccctga acagcaagca ggcgtttagc atgccgcacg 1440
gcggcagcct gcacgtggag cccaagtact cggcactgca cagcacctcg ccgggctcct 1500
cggctcccat cgcgccctcg gccagctccc ccagcagctc gagcaacgct ggtggtggcg 1560
gcggcggcgg cggcggcggc ggcggcggcg gaggccgaag cagcagctcc agcagcagtg 1620
gcagcagcgg cggcgggggc tcggaggcta tgcggagagc ctgtcttcca accccaccgg 1680
tgcgtatttc tgcataatca ccgcttaaag gcacattttg acagccccct ttatctgctt 1740
gatgtttttt tcatgtctgc acagcaaatc accccacacc tccaaccaat tttcccctct 1800
ctctctctta agtattcagc aggtcttgcc tttcatatta atttttatga cctgggatgt 1860
tgcctgtgcg cgtgttgtgt tgtgtttcgt tgtgtctaca ggctcacttt cctcctcctc 1920
ctgcactctc ggcttctttc tgtggcttcc ctctttttct cttcacctct gttttcagga 1980
ttattattat tattatttta acgatctggg aatgttgtag gcgcggcgac ggtgtcgagc 2040
cctgggccgg ggcttccgga gagagggcgt acaattccct gctgagcgta atgtgtgcct 2100
tctacttaca attgcagagc aatatattcg gcgggctgga tgagagtctg ctggcccgcg 2160
ccgaggctct ggcagccgtg gacatcgtct cccagagcaa gagccaccac caccatccac 2220
cccaccacag ccccttcaaa ccggacgcca cctaccacac tatgaatacc atcccgtgca 2280
cgtcggccgc ctcttcttca tcggtgccca tctcgcaccc ttccgcgttg gcgggcacgc 2340
accaccacca ccaccatcac caccaccacc accaccaacc gcaccaggcg ctggagggcg 2400
agctgctgga gcacctgagt cccgggctgg ccctgggcgc tatggcgggc cccgacggcg 2460
ctgtggtgtc cacgccggct cacgcgccgc acatggccac catgaacccc atgcaccaag 2520
cagcgctcag catggcccac gcgcacgggc tgccgtcgca catgggctgc atgagcgacg 2580
tggacgccga cccgcgggac ctggaggcat tcgccgagcg cttcaagcag cgacgcatca 2640
agctgggggt gacccaggca gatgtgggct ccgcgctggc caacctcaag atccccggcg 2700
tgggctcgct tagccagagc accatctgca ggttcgagtc cctcacactg tcccacaata 2760
atatgatcgc gctcaaaccc atcctgcagg catggctcga ggaggccgag aagtcccacc 2820
gcgagaagct caccaagcct gaactcttca atggcgcgga gaagaagcgc aagcgcacgt 2880
ccatcgctgc gccagagaag cgctcgctcg aagcctactt tgccattcag cctcggccct 2940
cctctgaaaa gatcgccgcc atcgcggaga agctggacct gaagaaaaac gtggtgcgcg 3000
tctggttctg caaccagagg cagaaacaga aaagaatgaa atattccgcc ggcatttaga 3060
agactcttgg cctctccaga gacgcccctt tcctcgtccg ctcttttctc tcctctcttc 3120
tgcctctttt cacttttggc gactagaaac aattccagta aatgtgaatc tcgacaaatc 3180
gaggactgaa gagggagcga acgagcgaac aactgagccc aagccggtga gaatgtgaaa 3240
cagtttctca aaggaaagaa taacaaaaga tggtatttgt ctgttgtagc aaagttgtcc 3300
ctttgaaccc cacctcggct tcttcagagg aagtgtggag atggctgttt gcaggaaggc 3360
agacgagaca gtgtttaaaa agtccacaag aatgatcaag taagatttgt ttttattctt 3420
acagacatca cccgtgttca agtttaaaag tacactttgc aactattttt cagaaataga 3480
aattgattca ggactaaaac tttaaactag agttgatgct taatgtgata gagacatctc 3540
taaagtattt tgaattttaa aaaaagatgg cagattttct gcatttacac tgtatattat 3600
<210> SEQ ID NO 255
<211> LENGTH: 4000
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_103872 genomic DNA region
<400> SEQUENCE: 255
ttctgtggcc ttgcttggtg acagggaatg gggtgtgatg agctggggca ggcttcctgg 60
ggatgctttc agccaaagat gagccctgtc tgcccttggc cctgctgaga gggtaagttg 120
agtcatgagc agaattcaac cagttatcag atggaaggcc aaggaagctt ggggagggct 180
actgagggga tacggtaggc ttgtctgtgg agagcaaaat tcttcagtct acaaagttct 240
tttctgggct ccttcatctt tcggtttctc ttccagctcc ctcgttttgg gcctcttttg 300
tttccccatt cccctcccct gggccttccc gtttggaaaa ggggtcacat atcctcaccc 360
tggaggcgtc tgccccttcc acacagttgg tgttggaaca gtggagctca gagaggccga 420
tgctgaccgc gtagatgtcc agcaccaaca gtgggatttt gggccctgtg ggggacacag 480
agagaactct ccgggagtgc ggccccttgg cctcccctct gggtgcccag tgggcagtgg 540
gcctgggtgg ctcagaatcc cagccaggag cactgaaggt caacaggctc ccgccctgag 600
ttttctgagc caggcctccc tgtttcctcc ccagccagtg gggagcgcag tgaggggcgg 660
ggcctggagt cttgggagct ccctggacaa caacatgcat ttagcgcagc tcagtctcag 720
agccagcagg atatgttttc ttaaaaaaaa aaaaaatgcc taacatcttg gctttcaccg 780
aagggttggt atctgctttg tacactttgg ccttcttggc ttttcactga aacacacaca 840
catggatgca cactcacttc cacacacaaa cccacaccaa gacagacaca cacacacact 900
cacacacaaa ctcatgtaca tggtttcata cccacatcca tgcaaacaca catacaaatc 960
cagaaatacg caccctcaca cccacaaact tgtacacaca cacacacgta tacacaccaa 1020
cacacataca accctggctt ggacaaaagc ttcccgtttt ttcttgtttg aagtggaaat 1080
ctcccacctt ccatgagatt caatttctcg cccttccccc gctaaaatcc tcctggcccc 1140
atcatttctt gggtcctttc cagacagtgc tgtgtcttta aggaagttga agctgctaaa 1200
agtgagtgag agagagagaa aaaacacaac ccaaaaaaat ttggcatctc ttcccccctc 1260
aagtttctgg tgtcacttat gaaacacagg tccttgttgc tgcagagaag cagttgtttt 1320
gctggaagga gggagtgcgc gggctgcccc gggctcctcc ctgccgcctc ctctcagtgg 1380
atggttccag gcaccctgtc tggggcaggg agggcacagg cctgcacatc gaaggtgggg 1440
tgggaccagg ctgcccctcg ccccagcatc caagtcctcc cttgggcgcc cgtggccctg 1500
cagactctca gggctaaggt cctctgttgc tttttggttc caccttagaa gaggctccgc 1560
ttgactaaga gtagcttgaa ggtaagccag tggggaggag ggctccaggg ccagcggcgg 1620
gagcgggagg cctgttggac ataggggctg gttccctctt ggtccatccc tgctggtctg 1680
aggtgcgtgg gacaatccct agcttggagc cgtccagggg gcatctgctt cttccacaac 1740
ccacaactga ggccccagaa atcccagctg cgtttgggct gagcctctgg cctcacccaa 1800
gtcagctgag aggtcctggc gggggtttat ttaggcagct gcctggctaa gtttgaacag 1860
aacaggccac gggtgtgatt ccacagaaaa ggcctggtgt ctgctgcggt catggccgga 1920
ggagcgggag agggcgggtg gagtggatgg gggtggtgtg cactgcacaa ggggcctcgt 1980
ctgggccaag gcaaagcata cctatggggg gctccggtgg gagggactgc ggccaggatg 2040
tgggagggca gggggaggtt ctgcaaagtg ctgggggagg ggggtggctg gaaaacagat 2100
ttcaagtcat aaagtcagct aggaacaggc cgaggcaggg agaactctcc actcggagga 2160
ggagctgggg tcctcttcca tcccgtcttc atcctgcctg gctgcgtgac ctcgggcaag 2220
tctccgccct tctcttggcc tcagtttctc cttccgtagg atgggggcgg tgggctaggt 2280
ggtgttggga tttagctggg ttatgtggga cagggcctcc tgatgggaaa gagctctggc 2340
tgggcttgtg ggaggaatga gtccctttgg caggttctcg ggatcccctg ggtgacatgc 2400
ctttctctgc aggaggcacc atgcaggagc tgcatctgct ctggtgggcg cttctcctgg 2460
gcctggctca ggcctgccct gagccctgcg actgtgggga aaagtatggc ttccagatcg 2520
ccgactgtgc ctaccgcgac ctagaatccg tgccgcctgg cttcccggcc aatgtgacta 2580
cactgagcct gtcagccaac cggctgccag gcttgccgga gggtgccttc agggaggtgc 2640
ccctgctgca gtcgctgtgg ctggcacaca atgagatccg cacggtggcc gccggagccc 2700
tggcctctct gagccatctc aagagcctgg acctcagcca caatctcatc tctgactttg 2760
cctggagcga cctgcacaac ctcagtgccc tccaattgct caagatggac agcaacgagc 2820
tgaccttcat cccccgcgac gccttccgca gcctccgtgc tctgcgctcg ctgcaactca 2880
accacaaccg cttgcacaca ttggccgagg gcaccttcac cccgctcacc gcgctgtccc 2940
acctgcagat caacgagaac cccttcgact gcacctgcgg catcgtgtgg ctcaagacat 3000
gggccctgac cacggccgtg tccatcccgg agcaggacaa catcgcctgc acctcacccc 3060
atgtgctcaa gggtacgccg ctgagccgcc tgccgccact gccatgctcg gcgccctcag 3120
tgcagctcag ctaccaaccc agccaggatg gtgccgagct gcggcctggt tttgtgctgg 3180
cactgcactg tgatgtggac gggcagccgg cccctcagct tcactggcac atccagatac 3240
ccagtggcat tgtggagatc accagcccca acgtgggcac tgatgggcgt gccctgcctg 3300
gcacccctgt ggccagctcc cagccgcgct tccaggcctt tgccaatggc agcctgctta 3360
tccccgactt tggcaagctg gaggaaggca cctacagctg cctggccacc aatgagctgg 3420
gcagtgctga gagctcagtg gacgtggcac tggccacgcc cggtgagggt ggtgaggaca 3480
cactggggcg caggttccat ggcaaagcgg ttgagggaaa gggctgctat acggttgaca 3540
acgaggtgca gccatcaggg ccggaggaca atgtggtcat catctacctc agccgtgctg 3600
ggaaccctga ggctgcagtc gcagaagggg tccctgggca gctgccccca ggcctgctcc 3660
tgctgggcca aagcctcctc ctcttcttct tcctcacctc cttctagccc cacccagggc 3720
ttccctaact cctccccttg cccctaccaa tgccccttta agtgctgcag gggtctgggg 3780
ttggcaactc ctgaggcctg catgggtgac ttcacatttt cctacctctc cttctaatct 3840
cttctagagc acctgctatc cccaacttct agacctgctc caaactagtg actaggatag 3900
aatttgatcc cctaactcac tgtctgcggt gctcattgct gctaacagca ttgcctgtgc 3960
tctcctctca ggggcagcat gctaacgggg cgacgtccta 4000
<210> SEQ ID NO 256
<211> LENGTH: 3100
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_56412 genomic DNA region
<400> SEQUENCE: 256
ggaaagaagg cagcaggaag agagaaggaa ggcaaccctc ctgcaaaggg tccagggtgg 60
cggtggtggg ggggacagtg atggcggaag aactcagtgt gctttccaag aggaatgggt 120
aggctgggaa acgggaagga gagtcagaat ttatcattgt ttggtttcac cctagggttt 180
tgaggcaaaa tttatccaga gcaggaaggt ggcaagtggg ctgccacaga atggccccag 240
gggcccgagg gtcagtgatg tgtgggatgg gggcttttag agttgaggag agcactcagt 300
gggcgctggt cttctggaag gtgggggagg ggccgagaaa tgatacggca atactggatg 360
aaaatgggga tctctgcaga agtaggggca cagctcaaca gcctttcccc ttcctctcag 420
tgtcctcgga ccccgcttgg gctgtggagt ggatcgaact tcctcggggt ctctctctat 480
cctctttggg atctgctcga accctccgag gctggagcag gtcctcccgc ccttcctcgg 540
tggacagtca ggacttgcca gaggtgctgg gcccctggtg gtggggggaa ggaggacgtc 600
atccatataa aggggatctg cagcccccac ccacgcctgg ccagccagct tctggctccc 660
ttttccggcg ggcggaggcg ctatccggcg gcgggccggg aggccgcccc cgtgccggtc 720
tgctctgctc ggcgctgtgc cagcaggcgg agagctcgcg ccttccgcgc tgacgtcagc 780
gcatcccggg ccgtatcccg ggagaccctg ttgcgtggtg atgggttgcc agggagacat 840
acaccttttc tctgggcctg ggccgcagct gcgcggagcg ccgggcacgg atggcggcgg 900
ctgaggggag cgaagcgagg gagggagagc aagctaagaa acacccagca ggtgctcccc 960
cgcctaggcc tggctggagg ctactggcgc caccctgggg gccctgtcag ccaggtaccc 1020
aaggggaggg atcgagggtg ggcctcaggt caaggggcag tgttggctgc ccttgtgagg 1080
gacgggaacg tgatagaaga gagctgggca atgccgggga gggatgtgtg cctccaactt 1140
cattaagtga gggaaacatt tgctggggct tgtcagggag ccctgagcca ggtacagggt 1200
ggagttagga acttacgtgc atcagactta ggccttgcca tcctgagctc cctcgggaga 1260
cagacaaggg caatgatggg ggcggggtgt gtcagagaaa agaagaggct gtcggctgaa 1320
agcattattt gcaggtgaca cttgagatgg gccttaagtg atggcaagca ttttttcacg 1380
taaggatggc attcttggcc cagaggaaag ctgagttcct tttcctggag gcaggcgggc 1440
tgcttgctga cagggattgg tggagaaggg tttttgtttt ttgttattta tttttatgta 1500
tttatttatt tgagacggag tttcgctctt gttgcccagg ctggaatgca atggtgcgat 1560
ctcggctcac cgcagcctct gcctctgggg ttcaagcgat tatcctgcct cagcctccag 1620
agtagctggg attacaggca tgcgctgcca cgcccggctg attttgtatt tttagtagag 1680
gcggggtttc accatgttgg ccaggctggt ctccaactcc cgacctcagg tgatccgcct 1740
gcttcggcct cccaaaatgc tgggattaca ggcgtgagcc actgcgcccg gcctgagaag 1800
gggggtttta ttgggcagag gagatcagca gtggattcaa aggaggcttg gaaggaggca 1860
agggtgtcac agagtgggat ccttcagggc ctgggtatga tgcctgcact aacctcactg 1920
gacagtagcg taggctagac aagattttag agatgtgttg tgaccagctg cactccagga 1980
aaactgttta cattatatct tacctcattc atccagcctt tgcatttttg tttgcttgtt 2040
tttgagacag agtctttttc tgtcgcccag gctggagtgc agtggcacaa tcttggctca 2100
ctgcaatctc cgcctcctgg gttcaagcaa ttctcctgcc tcagcctcct gagtagctgg 2160
gataacaggc acccgccacc atgccctgcc cattttttaa attattttta gtggagatgg 2220
ggtttcacca tgttggcctg gctggtctca aactcctgac ctcagatgat ctacccacct 2280
tggccccttg gcctcccaaa gtgctggaat tacaggcgtg agccaccacg cctggcccag 2340
cctatgcatt tttttttttt tttttttttt ttgagatgga gtcttgcacc gtagcctaag 2400
ctggagtgca gtggtgcgat ctcggctcac cgcaacctcc gcctcccggg tcctggttca 2460
agcaattttc ttgcctcagc ctcctgagta gctgggatta caggaacgtg ccaccatgcc 2520
cagctaattt ttgtattttt agtagagacg gggtttcacc atgttggcca ggctggtctt 2580
gaactcgtga cctcatgatc cgctcacctc ggcctcccaa agtgctggga ttacaggcat 2640
gagccactga cgcctggcca gcctatgcat ttttaagaaa ttattctgta ttaggtgctg 2700
tgctaaacat tgggcactac agtgaccaaa acagactgaa ttccccaaga gccaaagacc 2760
agtgagggag accaacaaga aacaggaaat gcaaaagaga ccattattac tcactatgac 2820
taagggccac aaatggggta cgttgatgga gagtgatttg ttaagagact acagagggag 2880
gacagactac caagaggggg gccaggaaag ctcctctgac gaggtggtat ttcagcccaa 2940
actggaagaa tgagaaagag ctagccagcc atcagaatag tccagaagag atggggagca 3000
ctacactcac tacactttgg cctgagaaaa tagcatggga ttggaggagg ctgggggaac 3060
accacttctg ccgacctggg caggaggcat tgagggcttg 3100
<210> SEQ ID NO 257
<211> LENGTH: 2600
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_18292 genomic DNA region
<400> SEQUENCE: 257
caagctccca ggtgatgttg atgctgctgg ttggcatttg agtagcaaag ctgtgccgta 60
tttaaagaat tagccctaac taccaatatg aaaactttac atccctgaat cttcaattac 120
tctgaggtga cactactatt attctggctt cacagtcgag aaggcactga gaagtgaact 180
ttccagagat cacagagctg agatgtggga aggcaggatt caaacttagg ttgactgact 240
gcagggcatt ttcaactgtt tgcctcccaa tattatctca attaataggt aacgagagtt 300
cgaagccggg tccagagcta tcttctgtaa cattcttctg ggtcgagtcc ctgccccgct 360
acggtatgtg cctagggtca acacaagggc tggggaaaga ggaaactgag cctctttttc 420
aacacaacag ggaggacgga gaacagacgg ctcctccggc agacgcgacc cggcccgctc 480
caaacaacgc ttcgggcagg agaaggttct ccgggtggtc cgcagccggg ctggaggggt 540
ggggcctacg ctgggaaaag gttccgggcg ggtcgtacca acgcgcgcag ggggaagagg 600
tttccgaggc caggacggtg tcgctgccta cgcgctcagt ggcgaggtgg agaaactctt 660
catccaccct cggctacctg ttcgagagcc atggcaccag gagctctcgc gtcccacagc 720
cgactcctaa agactcttcc tccggccccc ctgtcgagtg ggagtccccg gaaatggggg 780
ccgggcggta tcgggcaggc ggtggggaga agagtgtcct gtcatttacc aacttcacta 840
cgccccacac agatccaccc gcttatctgc cgccgccgta gcccttacca gttctttggg 900
cggcttctcc tgggtctttc caaacagccc catgacgaac tgaacccgtc ttgccccttc 960
cggctttcag ttccccgcgc ccaggcaggt cacgggcagc cgcctgggcg gggcccgcgg 1020
aaaaggaggt agtcccaacc cccagagtag ggagcggcgg cactagggga tgttgcgcat 1080
gcgccatacg cctgcgcaga atcgagtgag tgggagacta gtcaaaaagg ctgacgtcat 1140
cgcacatgtt ctggtcatgt ctgtgtgggg gagaccacgg attcggtgct tttcgtaagg 1200
tgtagaaatg attgctctga aagatacgaa tttgttggct acaactgctt ctaatacttc 1260
acctaaacct agatgttgca ccagaagtct ggatctccac gcagacgtgt acacttagca 1320
tcactttccc gacagcttca tctttgtgtc cagtaggcaa ctcacaggtg acaaaccaaa 1380
aataacctct ttttcctccc gccaacccac tcctcccctc tgcttgcacc accatcacct 1440
ggtcactaaa ccctaggcat cgtcctctct cccctcttac caagtcccaa ccattctaac 1500
ttcaatatgt ctgaacttca accctcccct ttccatccca actgcggtcg ttttttttca 1560
ggccatcgcc ctttccagcg tgggcgattc ctgcctagca tttgtccatg tgtgtcccgt 1620
cctacacgcc acactgaccg tgagcttaat cacactctca aaggaatctg actaaagaga 1680
actagacaca ttttagcacg gacagttcct gattaggcct atacggtgag ctgatggtta 1740
ctgtcattaa ctcatccgag gatggtgaag gggaccattt gttacctcag ccccatactc 1800
ctgtctctgg tggaatcata aaatggttcg gcagctttga aaacattttg acaatttctt 1860
aaaatgctaa acaaagccag ccttccattc ctagctattt acccaagagg gaaaaaagca 1920
tatgttctta caaagacttg tacacaaatg ttcatagcag ctctatttgt aatagccata 1980
aactggaaac aatccaaatg tctatcaaca agtgaatgga taaaccagtc gtgattgatc 2040
catacgaagg aatagtactg agcaataaaa aagtaaacta ttgataaatg caacagcatg 2100
gatgaatctc aaaataattc tgccaagtga aagaagccag aaccgtatga ttccatttac 2160
ataacattct ggaaaatgca aactaataca tagtgacaga gagtacatgg gcggttgcta 2220
gcggatagga gtggggtcag aaagaggcag aaaagaggga ttacaaagag acacgaagtt 2280
tagggggatg atggataata tcttgattgt gatgatggtt tcacagatgt atacaatatc 2340
aaaacttacc aggttggaca ctaagtatgt gcgatttatt ttatgtccaa tcatacttca 2400
ataaagttgt ttttaaaaaa gcactgcctg ttcattgtga aaagttaaac cctcattctc 2460
acttcctcag gggaaaaggt ctcaaaggat tcacaccaac tattaaatat agtgtgaatc 2520
ttctgaaacc ttttcctttg gaaaatatac ttttattttt atttatgtat ttgtttttga 2580
gaccgggtat cactttgtca 2600
<210> SEQ ID NO 258
<211> LENGTH: 2100
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_12075 genomic DNA region
<400> SEQUENCE: 258
gggatacttc aaggagaagt tgactctttg acttcataca tagagagact agaaattccg 60
atgagaatat acacgctgat gtgggatcag cttcccctgc ttcctcctcc ttggggcact 120
tgaaacaaga catccatatt cctaacaaca aattcctatt tgagccatct tgagactctc 180
cacatggacc actattgtgt aagttctcag ataataaaaa tttgagtaag catcaaaatg 240
tcctatttgt gctcagcaat ggtgatggct tttgaatcaa ggtgaagatc tctttcgtgc 300
ttctcactgt gccagaagtt acaccacagt gtttgtgtga tctgctgttg tctgttgtct 360
tattttcccc aagagcttgt aggtttctgg agactaggaa ccttgctgta tgatttctgt 420
ctccctcccg cagcactgag tatagtgata cgtgtgccaa ggctttgttt ttcagcttta 480
gagcctccac tgctaagcaa ctttccctct cagagtcgcc aggctggggc atctatccca 540
ggaaattggc tatttgggat gaatgtgggt ctacctccag gggtatttgt attttggtgg 600
ggaattcttg aaggcagcaa aatctgtaag ctcctcccca acaaagacta ccgggatgga 660
ataacagggc accccgccac tttattccca gcagtcacac tacctggcct gtgtgcttca 720
ttgacatatt gagtattgtt cactcgggca gaaaaaaata ccacaacctc acagccttct 780
tagtttcctg aaaaaagatc tgtcactttg aatttgctag tttgccaaat gacagctgtt 840
tgcctcccag gcaggctttg ctgtcatcag agacagggat ggagggaaaa taatgccatc 900
atctagggga agggtcttgt gttgatcttc aacatggcta accaaatgga cgatcagcag 960
gcagacacga ggtattttca ttttcactct tatttcaaga gatttgtgat ggtgtttcat 1020
agtctaaaaa taaaggatcc gcccgcagac atttctccct ccactaccct catcatatta 1080
gctgctgcgt tttcctctcc agattttgat tctattattt tttattataa atgaaaggtc 1140
aaggaatact tttcgtattc cataatagga ttggttctgg aagaatcttt gaaaaaaaaa 1200
atacgttcaa gacattgggg ctgggaatag aacggaagca tctcaaaagc atgtttttct 1260
ggttaaggaa agcacacgag aacgtttcac agcggtgctc tgctatcttc tctgtacccc 1320
tccgccctac gctcatggga gagctcattt ctctccccat cagacactgg gaaatactcc 1380
caaggctctg gcagtctcaa ggctgcaatt cctgagaccg gggactctgt gctgccatct 1440
cgtggcagat ctcagacaca gcaagctggc tgccggaatc ctgtttgaac ttggcttgcg 1500
gcgggagctg tggtttggct caaatcctta tagagctttg ttgccagtca tgttgatttt 1560
taaaaaatgt tttactccct atgcccccct tttagttttt catgttggca cttcatttaa 1620
tgtgcctcca gaggctacat tttgggtttt gatgtgtttg gtcaatgtta aagaatcggt 1680
taactatctt cctgaaagaa ggcagtaatg cagacagacg cctttgacag caggtagacc 1740
actggctggc aaccgtagaa agagggacac acgggagact aagaatgaaa gatgcagtaa 1800
ggtttattgc tcttattcat tggttaggtt tttttttttt ttttttttag agtattctga 1860
ccttttcctt gagtgtattt ttgctaccat ttctcttgtt tagatctgga gagactcaaa 1920
ctcaagctgg gatttgggga aaagtgtttg aggatgccag tctggctttc agaggcatga 1980
taggcacatc tctgttgata tccaaattgg aacaactttc cttgttacca gaaaacagct 2040
ggtgtctgca gaccttccca tggttggcca tgacacaggc ccctggagtt gctctgcttt 2100
<210> SEQ ID NO 259
<211> LENGTH: 2400
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_22519 genomic DNA region
<400> SEQUENCE: 259
ctttaaacag cacagatatg caatgaaatt tccattaatc cagaatatac atagtggtta 60
acatgcagtg atttgaaata aaatattatt tgaaaagcta tttttatagc tgcaaaatat 120
tgcattgaag aggctgccac caattatttg tttccatatg agcattttaa aggctgatac 180
acaacatttt aaaaatgtat atgcaccttg agaggcccag gcgtgcagat cacgagatca 240
ggagatcgag accatcctgg ctaacacggt gaaaccccgt ctgtactaaa aatacaaaaa 300
attagccagg cgtagtggcg ggcgcctgta gtcccagcta ctcgggaggc tgcggcagga 360
gaatcgcttg aacccgggcg gtggaggttg cggtgagccg agatcacgcc attgcactcc 420
agcctgggca acaagagcaa aactccgtct caaaagacaa acaaaaaact atatgaaaaa 480
gtctctcatt attttcacaa gcattaagaa tctcacttaa aaacatggct gggcgcggtg 540
gttcacgcct gtaatcccac cactttgagg gggcgaggca ggcagatcac ttgaggtcag 600
gagttcgaga ccagcctggc caacagggtg aaaccccgtc tctactaaaa atacaaaatt 660
agccggtcgt ggcggcgcgc gcctgtaatc ctaattactc gggaggctga gacaggagaa 720
ttacttgaac ccaggaggca gaggttgcaa tgagccgaga ttgcaccact gcactccagc 780
ctgggcaaca agcgcgaaac tctgtcgcaa aaaataaata aatacataca tacatacata 840
caaatattgc caatttgata ggcaaaaata tatgcaaatt atgttttaac aaatattaat 900
aaagttgaac aatggcccaa tgtaatttgt tacctatctg aaagacatgc acattcaggg 960
agttacagta ctttttcatg tcttgcagca tcaacaaatt gttttctaaa tgtggaaaaa 1020
gagacattca gtacaggcta acgtaacgtg ggacagcatg caaagccatg agaagtggga 1080
aaatgagaga gaatctgggc gtggcttaca gggctgctga agtaagacac acccttcgct 1140
tcacctgtgg cctcccgcgg cggctgcggc tccttcgcag gaccggtagg gggcgcgcgc 1200
ggttgagtcc agcaattgcg aggacctccg caggcgcagc ccagcactga cgcctctccg 1260
ggccgtggct cctctttccc aggccgaaag cggccgggcc ctctgctccg ctgcgccctg 1320
gcgcggccgc acccactgcg cgtttgtgag ctggccatcg gtcacactgg gatactcgag 1380
gaggaggcct ggggcctgca ttcaattccc taagagggac ccgcgctggc cgctgcaggc 1440
gggtggagaa cgggcgtctg agtctttggc tttcgtaccg gaatctcccc gggagatttt 1500
acaagcccct ccgaatgttc tgattgaatt ggtctggggg ggtcggtccg ggcatctaac 1560
gagcagccgg gatggagaat tactagtctg gattctggtc ctcagaggtt cactcacgtt 1620
aatcaacccg agtccatctt ggtgggattg tcttgctccg aggccctccc actgagcttt 1680
attttcctgc ctgatttcgg ggtccgctaa caggatgaac agcggaccat acaggcacgg 1740
tgaaaatgac acttggtgac gtggaagacc cagcttgcca cagttgaggc agagctcctc 1800
agggtctttt gtcttagtta tccccgagct atttttcagg aaccgacagg ctcccccacc 1860
ccaacaccgg atgaaggcca gcaactggag gccaggaata atcaagcacg ctctcatttc 1920
aaagaggtga cgattgtgcc cgtgtttaaa agggatgcct gagaccatga ggatttggag 1980
ttttggaggc ggatctgcct ttggggagtg agcgtagggc cctaagatgt ggttgtgctt 2040
tgagacagtt cccagggtga tgtgtcccat catccaaaca ttgcaggata agtcaaagtt 2100
acagaaagac tctagtttac ttccagccta acattaccaa aatacggtat ttgtcagaaa 2160
acatgtagta tttgtataat ttgagaatgt aattgaagaa cccgatatag agcttttaga 2220
aaggggaaat agaaaactta aaaagaatct tgcttggtat attaatacca acatctaaaa 2280
tataataaaa ttgaataaac cagtgagttt tatactatga ttgaaataaa atgccactat 2340
gttcttaaga gtgctagttt aacaggaaat ctccaatgca ttattatcta gactcatctc 2400
<210> SEQ ID NO 260
<211> LENGTH: 2300
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_29531 genomic DNA region
<400> SEQUENCE: 260
aagactgtgc ctcaaacaaa agctttgtat aactgccctt gtgttcaagg taatattttt 60
cctcttttca aagaggctgg aaagtggtga agggcatttt cagcaggctc tcctcctgac 120
agatcttttt ttcctgctac ctacctcgtc tccctttatt gtcccgccta cattcatctc 180
tttctccagt ttccaattcc aacctggtag cagctacaat ctggattgta tttaagggaa 240
ttgctttttt ttttttttct tgaagagcgg ggaggaaggg taaagtgggg ggaggggcgc 300
agaagcagta ggaccgacgg caatctccca cctccccaaa tccatttttt cttacctcct 360
ctgacctctc tagcttggaa gaggaaggtc aatgcgaggg ttgttacggt gaaatcccag 420
agccaccgtt tcgttttcca cctagaggac cacggctcca tctccgagcc ccgcactcac 480
aactgtgaac tcaacccacg aaattgcgac tgcagaccaa cttcgtcctt tccaaggtat 540
cgccagggat gtttgctaca cagccattgg ggagggagag ggggaaaaag tcaaagggct 600
ttttcttcta aatttgatgg tttgcgttct tcgtgtctct agccctttcc tctccctctg 660
agttggcccc accggccggg accctccggc cgcgaccctc tgatccttcc tctgccgggc 720
cctgccttca gaatgaaggc agatgagggg cttccaccaa caagctgaga gtactgtgtg 780
cccctaaagg cttcatgccg tcagtgggct ggacgagtgg ctccgggcag ccccctcctc 840
cgcccactcc cctccctgct cccagctccc cctcccaggg cgaaactgac aagcaggctg 900
agggtcagac ccaatcacac gactctgggg cggccccaag cccgcccccg cctccctcag 960
cccaagaatg aggactccga gcaggcccag cccaccaacc accccccatc tccccactcc 1020
tctcctccct cctcgcctac caaatccccg agaaaaaatg ggagggagtt acgggggacg 1080
cgtgcttggc tccagcactt tgggaatgaa aggaattgca ggagagcccc ggagcacacg 1140
gagttttcaa ggagcttctg tattcaataa aaacagctac ttgtctactt gcacccgtct 1200
gttagcctct cgctggtcgg cgggagaggg gaggaggcca gcgcctgatc ggccacaccg 1260
ctggagtcct gggctggcag cggtaacctt atccttgtgc aaaaatctgc ttcgtatggc 1320
agacgtggaa ccagtggact cattgcgctg cctactctga aaagtgtttt tatttttatt 1380
tttttaaccc aataattaga agaaaggaat gaagatagaa tggagggacc ctagaagtca 1440
aaacctagag catgtaggga agtcctcttt ggagatctga aactgacagg tttatctctt 1500
aaacgtttaa attcagcact aggttcattc agtggctttc ctcttaaaag agttgaactg 1560
tactctgagg gagaaggagg aaaaaattta tgggagctga cattaagagg gtgagtaatt 1620
taattttcca gctgattctg ttctgatcct ggatgagggg gtactgagga gtgtgtagaa 1680
aaggcgagga aagcaactag cagaaatctc caagaggctc ggcccacagc tcctcattaa 1740
gggcctggcc ctggccctca gcctcgggag ccaaaaacgt ggtcactcca cagtgagagt 1800
aatgaagagg gcaggtttct aaattccctc tctacttaac ccatcctcaa agtaatcctc 1860
ttacacctgg aatatagatt cccaagtcac tttttccacg ttaaaatcat tccattctat 1920
tgactccttt ttgttcgtta ataattccta agatgtttct ctcaaagatt ttctggaaca 1980
gtgcccatca gggtgccagc atacattagc cactcaatag agatgggttg gatgaatgaa 2040
cacatttttc tgttgacaaa gactagaagc attggccagg gcctactttg agtatttaag 2100
tcatttaaat gcttaaaggc cctcaactaa gtttactggg tacatatgtt caattctaca 2160
gctgccacta atctttagga actcagtttt ctattagtca tcaaaatatg cctcatgatc 2220
tatcagatta catcaaatct cttcatgcag tttaaaattg gaagaaaggt gatcaaagac 2280
tagattgagc ccttataggg 2300
<210> SEQ ID NO 261
<211> LENGTH: 3400
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_58853
<400> SEQUENCE: 261
agtgccccct ctaattgtct attcttatgt gctgtttact gggtcattaa aatcttacaa 60
ggcctttata gtcattgtaa ttgttgaatt caaggtttgt cccagttgtt tgtacagaag 120
tctctcactt tgaaactcag aaacatttcc cctaacatct tgtctaaaag aacctttcaa 180
gcaatgtact gaccaactcc ttgagtgatc tgtggcccct gcaggagtgg gggtagggag 240
cgccatgtcg cacacctgtt gtcaggtgac actgccagca gcatcctgca cactcacctc 300
cccactccac cccaccccca gcgaggctct ttcctgctgg ccttctccac ccggggaagc 360
ctacagcctt ccggagttac cttttaaaaa aagcaaaccc ttcctaccac aaagcaaaca 420
aaaggctgat accgagacaa tcgggagcag cgggggttcc cgtggcccct ctccagccca 480
tccttggacc actccccaac ccggtccccc gcaccagccc ggcttcaatc ccgcgagtag 540
cccccgcctt cccctccctg cagatagcga gccagacgcc tacacctcgg ccccccgggg 600
ctcgggcccg acttattgtg ccggggccgg caactcgcgg gccggcgggg gcctcaccaa 660
gtacaactct gctcacagca gctcccgggt gcccaggccc agactgccta gccagcgccg 720
cggggcctcc tgcggcctcg ggcctggccc gtgagcccgc cccaggaagg gtcgccaggg 780
taggcgccag caccgctttt ttcccacaaa agcgcccagg cgcgggcagg gggatgcgtt 840
tcgaagagaa gttggtttcc aggtttcttt tttgaacaaa accaaaggga atcccgcgcg 900
gcccgacaag gcctgggagg acgtagtgca cgcgcgagga cccggcgtgg gccacaccga 960
acccggcggc ccgagcccgg cccgcaccac accggtgcgc gccaggccgg gccgctcccg 1020
ggcacccgcg gccggacccg agcggcgggg acagggagtg cggcaagggg gcccgcgcgg 1080
cacttacgcg gcggctcggt ggcggcggcg gcagctgcaa ggtgtctcgg cctgagccct 1140
cctggccgct cgcgcctttt ctctccgcgc tcctcgctgg cccgcccgcc tcttcgcttc 1200
ccgcccgcgc ggcccgcgct ctccccctcc gcccggcgcc gctgccgagt gaactggaac 1260
cagtcctcgc ggccggcttc ccacaatgca cagcgcgccg ctcgtcacat cccttcgcgg 1320
ccccgagcgt ccggcctccg cgcccgtgcc gcccggcgcc ccggccttga ccccgggccc 1380
gcgccctacc cgttgacgcc ggccgctctg cgcccaggca ccagcccgca ccccggacgc 1440
gaggtctgac ccatgacccc ggggacgccc agagcccagt ccttgggaag ggccaggccc 1500
ctggagagga gcttcttcag ggcgcgtccc agactctgcg tctcgagtga acgcctactg 1560
tgtgcctggc tctgagcacg ggactgtcgc tgccacggca tctttaggaa ccttcccact 1620
aacccagtgg gaaggcacaa tggctgttac cagcgatcgc tcttccctcc ccagtcaatg 1680
ccaactcccc cctgccccgc ctcagagacc ccgctgtctt tagatacagg ccaccgccaa 1740
gccctggtct gccccaagat caattactgc gcacccggtt cccctggggt ccttcagtta 1800
atcctcctca ccccgaagtc tggaacctgc cttgcacatg gaagcggtta gctacttcgc 1860
ttcagcaaaa gttcactttc ggacccaagt tgggaattac taatgtagac agtgattcct 1920
tatcatcaca cacgtttttt aaaaactgcg gacaggccga aagaggagga gccgccacaa 1980
agcccgccac gtcttcctaa attggtttac cgcctgaagg cattggtgcc ccatcccggg 2040
tacttaaatg ggggcctgcc ctctactccc ctccctccaa agtgtggagc cggaagccac 2100
ttctccatcc agctgtgaac taaatttgga taataataca catccctcag ggttgatgtg 2160
aagtttaaag tgccgctact ggggattatg gaggtaatta gagaccccca cccccacccc 2220
ccagtcctca ggctgcgcgg gaatcgcagc ggcagtaacc tccacctcac cgggatgctt 2280
tacaccttac tttaagagtt tgcaaaacaa tgtccaatac ctgccattca tgcattcgtt 2340
aattcgatta agtactgaga acgtattttg tgtcatacat cgatttgggt gctggatatg 2400
aaacagccaa gagaacaggc agaaatctct gccctcctgt agtttgcagt ctcgtggggg 2460
aaagacagac aaacgggaga atgtgtcaga gggtctccat ggggtggaga aaaataaggc 2520
ggagaagggg aataggaagt gtgagataag agtgaggctc aaatacaaga gaaggcctct 2580
atgagaaagt aacatttaaa gcctgaagaa attgagggag caagccgtgt ggatgtctgg 2640
ggaagaactg cgccgagcat gaggaatagc aagtgcaaag gctggggtag gagtgtgtcc 2700
aaaatagtca agacagagcg agtgtgaggt tggagtagaa tgggtgaagg ggaaagtaac 2760
aggagatgaa gctggaaaaa tgatgatgct tatgatgctt ctggtcccaa aacaaagcat 2820
tatggttcta tgaggatctc ccgaagaaaa gatgtcagga aaggtgcaga gaccctcccc 2880
cacacaccac attgttgttc catccttctc tgtgcctttg ggcaaggact ctccgttctg 2940
tagggaccac caggtggaat taaagtctac actcctccaa gagctgatct tggggcggcc 3000
ccacctccat gcccctctac agcgtgccat tctcatagaa cacactagga cctttgtcct 3060
ctggagctgt tcagtgcagc agctctgacc tcatccttct ccagaagcct ccaccttctc 3120
tcccctctct cctcctgcgc tttgtgtgtc ctgttcttcc acttcggtga cctgtctcct 3180
cccctaatct ggctcagaga ggggtaccag ctgctgctgc tgctattgct tcttcttctg 3240
ttaaaggttt tttatttttt tccaatgaca aagctatgct cattctgaaa acatgaaaaa 3300
taaaaatgct caaaaaataa aactcactct acattcattg ctaggagaga acagcctgct 3360
cccattccag cctttttatc tatatccact taacattaaa 3400
<210> SEQ ID NO 262
<211> LENGTH: 1060
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_35052 genomic DNA region
<400> SEQUENCE: 262
cagaagtttt ggccatcgta tgcttgggga cagacctggg caaaagccca cagaggaagt 60
tgccacaaac acatgatcta ccctcctggc cctgaccgca gggcttttgg gtttggtcca 120
cagacagagc cctagtgttc tgtttgttac cctgattgat tgatgagagg ttttggggga 180
gaaaggactt cactttcttt tcttttcttc tttttaacct ttgcctcttc ttctaggaga 240
acttcgcttt ctacactgat tataatttag acatcttccc agtagggctg aatcctagac 300
caatctatca atcccagact aatcaggcat ttgcctgggg atatgcatct ttggcatttt 360
tccaagggtt catcaggatg gagatatccg gtgcaccatg agttctgttt ccttaatcaa 420
caccgttgta acttgcccat ccagttttgt gacattaatt caaacctgtg ccctagtcct 480
cttttaggca gcgtatcagt gctggaaagt gcagcaagga taagagggta ctgttctctc 540
atttctgagg gcgttgtctc gataattaac taacttgata gactttttag tgagtggcag 600
gtgagatgca aggtactgtg ctaggtgctg tgggggatgt acagacaaac aacacacctc 660
cctaaggagg taagtaatag ctacttacta ttcactttgc tctttcactg taatgtatcc 720
tcaagcacag gttttcacta caccatcagg cccagaagta ctagcttatt ttccacagga 780
ggatttcagt ttgatgcctc tggttatctt gtatagagag gtcttttctt tctttctttt 840
tttccccctt cttttgcaat cacaaaatct gtcctaccag atgtgcctct cttgcttggg 900
aacccaatag ttttctttgc agacaacaga cttgaagtca cagagcagca gattgtagaa 960
gagctacagc ttcgggacct ctgactcttg agctggaaca gcaatagggc tgggttgggg 1020
gtggggtgga tgtgtctttc aatactgatg tatttcaagg 1060
<210> SEQ ID NO 263
<211> LENGTH: 1900
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_67002 genomic DNA region
<400> SEQUENCE: 263
tggatcaaat atttttttaa agggaagata aaagctgtgg tatcttttag ttcacgtcac 60
tttaatcttt gaaaaataaa aacagcctca aatattattg gtaaaataca gatgttgtca 120
aaatataaat agacagacta aattatgcag ttcaggtagc gccctgccga ccctgtctct 180
taaaaaacaa aaaaacgggg tcacctttcc atcccttttc taacggtttg aatctcagga 240
ctgtattcct aggcccctgt tgcttatgct gccctgtggt gcccaggtga gcttttattc 300
tgagattggc tggttggggt atggataaca atcgaaggct ctgttaccgc aggcgtgttt 360
ctgagtcctg ctcccgcccc atgcccgagg gtgcccagac tcaccagctc gggtcgcggc 420
tcgcttcccg gcaggcgccg gcctactggc ggcaggcaca gagcccccag cgtgcggagg 480
cgcgcggcgc agctcctcag catggctccg ggccgcgggg ccgcgcttgc tctagccctg 540
gacggcgcac tctacctccg ccacaagagc gcgcgtgcga gttaacccct ggggtggacg 600
cagggcgggg cttggggagg aggcggtgcg cactactggc ggctggctgg ccggggtgtg 660
aggccggcgg ggtccgggta gggcatcgct gttgagtcta tcttctggtt ccggcctttt 720
ctttccgaag acctcccgct gcggccaaca gccgggccac ttccggggct tctcaaaggc 780
aagaggagcg cggccggagc ggatcccggt tatcgccttg ggcccctcag cccctcagcc 840
ccggaacccg cgcgccgact ggaggctttg cggtcatcct tcccacatga cccagggcgt 900
acgcagtgct ccgtgtcccc aagtagttat ccctcccccg gaagactgaa gtccctgggg 960
cgggtaggag cgcacgctag gagtagtatg aataaagtgt tttcttggag gtcatgggca 1020
agtctctgga cagggttgat agtgctgatt tatagagggc agtctgggca caaagagcat 1080
ttatacgatc gaaaagctgc tttccctgcc aacagcccca taccctcccc aggagcgcgc 1140
ttacgcctta aaagactctt ttgttatgta aactgacagt taaattaaac gaaggtaatg 1200
gatactaaag gcgtaacagg tattgtaact attttactgt tatcgatgct tttgaggtta 1260
cttacctcgc ttgtattcgt atggtgggaa tactaggcgc ataccttctg agcttcgaat 1320
tcagtaacct cactgggacc ttgaaatcgg actgggttgg agtattccca ttactcagat 1380
aatgcaaatc cgggccatca taccccttta tttttaaatg cttaccagta tgccatagcc 1440
ctagtccatc ctaaggtgaa gactctaatg ggtttttttt gagacagagt ctcgcagaga 1500
tactgctatt gcacttcagc ctgggcaaca tactgatgcc ccatctcaaa aaagcaataa 1560
attaaaaaga aaactcgaat gacctgaatg cattagatat tttgccttga ttcctttccc 1620
atgaacaact ccagcagttt gtcagtaggt aagaacacct agatacattt taagcctaca 1680
ctattaactg ggggaaggtg taacattctg agagaaaggg aattggggag agaaggcaat 1740
gcagttagga ggggcccctt ggaatcctag agctactgaa ccgaagatca ggcataaagg 1800
atggttgttg agattctgta attctaagag gttgtattct gatatctcct aagcaccccc 1860
cccaacctcc cacattccct ttatctcagt tgtcttcctt 1900
<210> SEQ ID NO 264
<211> LENGTH: 2100
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_45580 genomic DNA region
<400> SEQUENCE: 264
ctgagccatc tgcaccctga gtaggctctt gagctgtgac atgagtcagg tggagtagcc 60
accaaggcaa tagcttccct ctggcacccc aaatgcaggc tcacattctc tccagcccag 120
gcagttggat gagggcccgg cagatatctg cgggcccagc aggcggggac cttcccacct 180
ggagaaggca cctccaggct ctaggtctga agtttcccaa actctgtact cctctccatc 240
cagttcactc cagtctcctc cagctgtctt tgagacagca tgcccaggag ataggacaaa 300
attagtacca agactcacct gagtgcccct ggctgaggct gtagagcctt gtcccctcag 360
atctcagcat ttgccatggt ggccagagag ctggctgcca ccacgctgag agccaggccg 420
cccctcggac cgcgtcccca cagccagcca aatccagatg gagtcataga aaggggctgc 480
aggggcgccc agggacgagt ctcagagcag gaccacaggg gccacttctg caggaggacc 540
aggtcaagat gcaacctgtg gcagagtggg ggtctgggcc tgggggaccc agaatggggg 600
gtgtgcgcct gggactccct gtccttggtg cctggtcctg ggtagcgatc aggagatgtt 660
ctgaggaggc accggcagct cctctaggta ctgcctgaga tgcgaactgc agctgctctc 720
gccgccagtc cgtataaaat aaagttcttg gagcagttgc ggaggcttct gcaatggggt 780
ctggaatacg gcccccctcc tgcggccaat cgtggcatta cagccccgtg tgggaacgcc 840
cgctgggccc agagcagcgc ggtcggcctt ggccttggga ctccaacacc ccagtctaaa 900
ggtcctgctc aaaatacttt ttggaagact tctgggggag tggcagctag acctggctta 960
tgagccacgc aagaaaacca gtcttgtaaa tttatttata gcacagaatt ggcatggctc 1020
aattcattca ccaagcttgg cacagagtta cttcatgtat tttcctggag tcacattcat 1080
cctcagtgga cacggattgg ccacactggg ggtagtcagg aaaatgcccc agggggttcc 1140
acggaactca gcagcagaat cagcgtttct ggctcattaa cgctgcacag gggctggggg 1200
gtgcaggatg aagactagct ggctgtccat agcaattcag tatgggaggg ggacccaggc 1260
acgaataatc ctaaacctga gcatgattgc ttacgtttga aaaaggacat ctaggccggg 1320
tgcagtgact cacacctgtg gtcccagcac tttgggaggc tgaggtggga ggattgcttg 1380
agcccaccca caagttcaag accagcctgg gcaacatagt gagaccccat ctctaaaaaa 1440
aaaaaaaatc tctttaaagg caatctaacc atatgtgaag ggagctgcta aattcagatt 1500
gaggtggtag tatcaggggc atcagagaaa tcaccataat tgtccaagcc agggtggcag 1560
agttaggcta tgcagatggc ttccagagga cagcacccag aggtaacatt catgaatgca 1620
ttcctgtttg ttggtgaaaa gttcagcctc aagactccag ggtcaggctt cgtacatgaa 1680
aagtgtttgc caagactcag ctgtgtcact gcagctgccc gcccacagct gagtcagaaa 1740
cgccgtcctc attctcagtg actgccctgc ctgactgcct aggaagcagc tccaacatca 1800
aactccattt tacagaaaga acaaatgata attgtatcat tatggtaata atcccaggga 1860
gcggaggagg agaaggaaaa gaagacaaca ctttatagca tataccatgt gtttcttata 1920
tattagctca ttgaacctat tcaacaaccc cctgaggcag gtgctgctat tatgctcatt 1980
tacagagaca gagaggaagt gacttgtcca gggtcttgta gccagtaagt ggcagagcta 2040
gtattcaacc ctaggcaatg tgatcctagg gtctatgctc ttaacccctc ccctgtacca 2100
<210> SEQ ID NO 265
<211> LENGTH: 2900
<212> TYPE: DNA
<213> ORGANISM: Homo sapiens
<220> FEATURE:
<223> OTHER INFORMATION: OGHAv1.0 microarray feature identifier
ha1p_12646 genomic DNA region
<400> SEQUENCE: 265
gcggtgcatg gcacatggag ctgacctgaa aagaggaaac aaggaatcag catttaggcc 60
ctcacctgct tctcctgccc cttcccagag cctgctaggc acttctcccc gcaactcacc 120
taggagggct agggcctgcc cccctgcttt ttggcaggaa ggatggggca cagctcaact 180
tcttcctcat cactgtcctc ttcctcttcc tcgctctcct cctcagaaac atcattgctc 240
atcgtaactg gtggacacac aagcagtaga aggatggggt gttaagacca gaccgtttca 300
caccgcatgc catttcttca cgccgtggtg ttaggcttac agggaccatg acctcccagt 360
gcttatgggc taggtgggaa gaacctcaga ccctaaactg ggtcacaaag agccaaagga 420
gtcttcatta ttggagctgg agaagttggg ccatgttcca tggaggaggt aggcttgagt 480
agacggaaag gagagggcat gtcatgcaca gggcacagcg tggagggcac acagacctgt 540
acagggctgc actgggagat gagggtggga tggggcagga gtgcggagtg ggggaagcct 600
gatgggagag tccactggaa gcaaaggaga gggccctccc ctcttctcac caatctggtg 660
ccgcccagtg atccgcacag ggccagagcc cgacttcagg cggaaggtta caggtggttg 720
gagctggaag tcatccagac tgagctggga ggaagacaag gatgaaggcc tggcccactc 780
ctagcccacc ccacactgta atgagtgcta acgtcctcaa tcccctcacc accaccacca 840
ccaccaccaa ggcagagctg gggaactcac catgggttgg caggacagct tgaggttggc 900
cacagggact gcgatctcct gatggtcatg gttccgggcc acaacttcta ccacattaca 960
ctcgtctttg gctccctcgg tgaggcagag ctgggaacgg tacacagggc ctcagggtct 1020
cctcaagtga gggttgacac cacaactaaa ggcatctacc ctagcacctg cccagcctca 1080
gaggtcccgg ttcacctggc caggggagcc gcccatgccg gggggttagg ctgaggatgt 1140
gtctccaagt aaaggggatc cggaggttgg gtagagacct atattgcctg cctgggctta 1200
ttcattaaaa ccccactccc ctgcccctca ccatggttag tgccagcacg tgctccgcat 1260
catcctcttc ctctacctta aaggtgaagg agcgggtgtg gccggagagc tcacagcctg 1320
gtagaaataa cagtgagtat gcctgagcgt gtgtacgggg ctgggcagcg ggggatgtca 1380
ccaacccgcc gtcacgtgta accttgggcg gacgggtcat ttacacgtcc acctccgtct 1440
cttctctcag aacacctggg acgctctgcc gtgggccccg cccaacacat ctggggcagg 1500
gatctcgcca ccccctttgg ctgtgcgtgc gaggccccct ctcctgcggg aacagcgaag 1560
cagccctccg cccacaccca cgccttgaaa ccctccgcat tcccgcctca catccctacc 1620
tcttaccgcc ccagtaccac cctcagcctc tcccttcact aataccgaag aaaaaactgt 1680
ccatagtgac cggggccggg acccgtaggc ccccgacacc cccggcccgc gttcggctct 1740
cctgactcaa aaacgctaag gcagctgcag taccggcggc catgctgtaa gagccttctt 1800
caaactccgc ccccgacacg cacaaagccg gggaccctcg gccagttccg gccccgccca 1860
ttaaaggaga cgcacagtcc tggaaaagaa aaggcgccga gaccccgcag ccctacccgg 1920
agcccgcagc ttctgctcat attttatcaa gaccgaagag aaaggaagta acatcacaga 1980
agaatggatt tggggtttat gttaacatcc ttgctcattt ccacgaccat gagggtgtcc 2040
acttccccaa gctcctcgct ctgtgtcgga agagtgtctc ccactcttcc aacccagggt 2100
aagctttcgt taaaggagtt atagatataa aaatgtaaac ccttcttact cctcccagca 2160
aaggtggggt tcagggcagt gcttttctgc tacaagcaaa ggaaatgcac tcagattgtc 2220
tttgcctcaa gagagccgag gagccttagg aatttccatc ccaacacgtc tgtcctgtct 2280
gtcctctcgg ctaagcctct cttaattctt cctgctctaa agaccccgca acttgctatg 2340
ccttcactga gacttagctg ctggcacttg ctagcagagg actagttagc tcatgtgtgt 2400
tggctgttcc tggcccaccc acgctttttg agcttttaat tccaaatcat ccaggagtat 2460
ctttgcgccg tggattattt tgtcagttta tgctactcgc gccatctttc gccttttaag 2520
aatcaggcaa actgtgtgct ttctatccta atagatggca aaactcaaac tagaggccct 2580
atttcacatc caggttataa ctgtggcaag agggtggggt ggcttggcta aaaactagtc 2640
tacttttctt agctcttgtc ttaatgaaaa tctggaagtc ttactggtga tggaggtagg 2700
ggagggctgc cttcaagatc caatctctaa cttggaacag ctgtggagag gagagaatac 2760
ctgcttgtag gtgaggcatg aaagaggaga aaagggaggg ggcagacagg aaatagattc 2820
acacaataca acacgacaag cattcacttc aagttttatt ttgcctcttg catggtcttt 2880
tacagttcgt tttctacagg 2900
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