Zubieta
Angel Zubieta, South San Francisco, CA US
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20140079296 | BIOMETRIC IDENTIFICATION VIA RETINA SCANNING - Various systems, processes, and techniques may be used to achieve biometric identification via retina scanning. In some implementations, systems, processes, and techniques may include the ability to scan a retina using a scanning laser ophthalmoscope to acquire at least one retina image, analyze the image to identify retina blood vessels, and identify a plurality of branch points of the retina blood vessels. The systems processes, and techniques may also include the ability to calculate a data set that represents the identified branch points, compare the calculated data set representing the branch points against at least one pre-stored data set representing retina branch points, and determine whether the calculated data set corresponds to the pre-stored data set. | 03-20-2014 |
Antonio Zubieta, Monterrey MX
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20080277249 | Circuit breaker with improved lock-off accessory - A circuit breaker comprises a housing containing a trip mechanism, a handle coupled to the trip mechanism and movable between on and off positions, and a lock-off mechanism capable of holding the handle in its off position. The lock-off mechanism includes a base member adapted to be mounted on the circuit breaker housing adjacent the movable handle. A slide is mounted on the base member for movement to an advanced position in which a portion of the slide projects into the path of movement of the breaker handle for engaging the handle and blocks movement of the handle from the “off” position to the “on” position. In the retracted position of the slide, the path of movement of the handle is unobstructed by the slide. A key-operated lock is also mounted on the base, and a lock shaft is coupled to the lock and mounted for movement to a locked position in which the shaft engages the slide when the slide is in its advanced position to block retracting movement of the slide, thereby locking the breaker handle in its “off” position. In the unlocked position of the lock shaft, movement of the slide is unobstructed by the shaft, but the slide interferes with advancing movement of the lock shaft, thereby preventing the lock shaft from moving to its advanced position. | 11-13-2008 |
Chloe Zubieta, Fontanil-Cornillon FR
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20130102600 | Heteroaryl hydroxamic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease - The present invention relates to a compound having the general formula I, optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, | 04-25-2013 |
Chloe Zubieta, Le Fontanil-Cornillon FR
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20130023565 | INFLUENZA A 2009 PANDEMIC H1N1 POLYPEPTIDE FRAGMENTS COMPRISING ENDONUCLEASE ACTIVITY AND THEIR USE - The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the PA subunit of a viral RNA-dependent RNA polymerase possessing endonuclease activity, wherein said PA subunit is from Influenza A 2009 pan-demic H1N1 virus or is a variant thereof. This invention also relates to (i) crystals of the polypeptide fragments which are suitable for structure determination of said polypeptide fragments using X-ray crystallography and (ii) computational methods using the structural coordinates of said polypeptide to screen for and design compounds that modulate, preferably inhibit the endonucleolytically active site within the polypeptide fragment. In addition, this invention relates to methods identifying compounds that bind to the PA polypeptide fragments possessing endonuclease activity and preferably inhibit said endonucleolytic activity, preferably in a high throughput setting. This invention also relates to compounds which are able to modulate, preferably to inhibit, the endonuclease activity of the PA subunit polypeptide fragment or variant thereof of the present invention and pharmaceutical compositions comprising said compounds for the treatment of disease conditions caused by viral infections with viruses of the | 01-24-2013 |
Chloe Zubieta, Grenoble FR
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20090192720 | METHODS AND COMPOSITIONS FOR DETERMINING ENZYMATIC ACTIVITY AND SPECIFICITY OF METHYLTRANSFERASES - The invention provides crystalline O-methyltransferases and isolated non-native O-methyltransferases as well as sets of their structural coordinates. Also provided are methods of predicting the activity or substrate specificity of putative O-methyl-transferases, methods of identifying potential substrates of O-methyltransferases, and methods of identifying potential inhibitors of methyltransferases. | 07-30-2009 |
20110306073 | METHOD AND COMPOSITIONS FOR DETERMINING ENZYMATIC ACTIVITY AND SPECIFICITY OF METHYLTRANSFERASES - The invention provides crystalline O-methyltransferases and isolated non-native O-methyltransferases as well as sets of their structural coordinates. Also provided are methods of predicting the activity or substrate specificity of putative O-methyltransferases, methods of identifying potential substrates of O-methyltransferases, and methods of identifying potential inhibitors of methyltransferases. | 12-15-2011 |
Jon Zubieta, Syracuse, NY US
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20090148382 | Technetium- and rhenium-bis(heteroaryl) complexes, and methods of use thereof - One aspect of the invention relates to complexes of technetium (Tc) and rhenium (Re) with various heteroaromatic ligands, e.g., quinolinyl and isoquinolinyl ligands, and their use in fluorescence and radioimaging for a variety of clinical diagnostic applications, as well as radiopharmaceuticals for therapeutic applications. Another aspect of the invention relates to quinolinyl and isoquinolinyl ligands that form a portion of the aforementioned complexes. Methods for the preparation of the technetium and rhenium complexes are also described. Another aspect of the invention relates to quinolinyl and isoquinolinyl ligands based on derivatized lysine, alanine and bis-amino acids for conjugation to small peptides by solid phase synthetic methods. Additionally, the invention relates to methods for imaging regions of a mammal using the complexes of the invention. | 06-11-2009 |
Luis Zubieta, Oakville CA
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20130121033 | DC-DC CONVERTER CIRCUIT USING LLC CIRCUIT IN THE REGION OF VOLTAGE GAIN ABOVE UNITY - The present invention provides a series of DC-DC converter circuit designs, and DC-DC converters based on such circuit design, that provide high input-to-output voltage conversion. The converters include a resonant tank and a means for interrupting the tank current to produce a near zero-loss “hold” state wherein zero current and/or zero voltage switching is provided, while providing control over the amount of power transfer. A resonant DC-DC converter for high voltage step-up ratio in accordance with the circuit design includes: (a) a low voltage DC-AC converter, (b) a resonant tank, (c) a high voltage AC-DC converter, (d) a (i) common ground on an input and an output without use of a transformer and/or (ii) a single high voltage controllable switch within the resonant tank. | 05-16-2013 |
20140265567 | POWER CLIPPING METHOD AND SYSTEM - An improved method for controlling an electrical distribution system of the type having a plurality of electrical sources, a load, a DC link coupling the electrical sources to the load and a control means for controlling the output of at least one of the plurality of electrical sources so that the plurality of sources deliver to the load an amount of power appropriate to the load. The improvement comprises an adaptation in respect of the load that provides for the DC link voltage to vary; and an adaptation of the control means resulting in the output being controlled as a direct function of the DC link voltage. | 09-18-2014 |
20140292303 | DC/DC CONVERTERS - A method for transferring power between two DC circuits, each circuit being bipolar or connected at the midpoint thereof, involves: coupling the high voltage bus across a pair of inductors, arranged in parallel; coupling the low voltage bus across the pair of inductors; coupling the high voltage bus, the low voltage bus and the inductors by active switches and diodes, to provide for: (i) a storage configuration, wherein energy is transferred from one of the buses and stored in the inductors; and (ii) a release configuration, wherein energy is released from the inductors and transferred to the other of the buses. | 10-02-2014 |
Luis Eduardo Zubieta, Oakville CA
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20150162840 | DC-DC CONVERTER CIRCUIT USING AN LLC CIRCUIT IN THE REGION OF VOLTAGE GAIN ABOVE UNITY - A method of operating a resonant DC-DC converter is provided where the resonant DC-DC converter includes a high voltage boost LLC circuit. The method includes providing variable power flow control to the LLC circuit with externally determined input and output voltages using frequency control. Frequency control is applied such that it emulates different loading conditions. For fixed input and output voltages this corresponds to operating along horizontal curves on the voltage gain compared to the switching frequency operating plane. A DC-DC converter is also provided including (A) a low voltage full-bridge or half-bridge DC-AC converter; (B) an LLC resonant tank; (C) a high voltage AC-DC converter or rectifier; and (D) a high voltage controllable switch; wherein the high voltage controllable switch is controllable to regulate power flow from an input to an output of the DC-DC converter based on an externally determined voltage gain ratio, wherein the LLC resonant lank operates with a minimum boosting having an effective value above unity over the entire operating range. A method of designing a resonant DC-DC converter for high voltage boost ratio is also provided. | 06-11-2015 |