Patent application number | Description | Published |
20110015093 | HIGH THROUGHPUT METHODS FOR FUNCTIONALLY DETERMINING RNA INTERFERENCE EFFICIENCY - Provided is a single construct combining a sequence encoding an RNAi molecule, a sequence encoding a reporter, and a target sequence specific for the RNAi molecule. The construct can be used to determine the potency of the encoded RNAi molecule in a direct and unbiased way. These results can be used to inform the design of potent RNAi molecules of various types and can be extended to several other applications, including: (1) generation of tiled libraries comprising every possible RNAi molecule-encoding sequence for a given gene target; (2) large-scale parallel validation of RNAi molecules targeting many genes to generate validated RNAi molecule-encoding libraries; (3) experimental comparison of design algorithms and strategies; and (4) investigation of RNAi biology in target site mutagenesis assays by screening pools containing single nucleotide changes in target sites and/or in the RNAi molecule to identify the most relevant sequence characteristics of potent RNAi-target site predictions. | 01-20-2011 |
20120272346 | IDENTIFICATION OF RNAI TARGETS AND USE OF RNAI FOR RATIONAL THERAPY OF CHEMOTHERAPY-RESISTANT LEUKEMIA AND OTHER CANCERS - Provided is a mosaic mouse model for use in determining the potency of an shRNA in vivo for reducing survival of cancer cells of chemotherapy-resistant leukemia. The syngeneic mouse recipient is transplanted with tet-on competent leukemia cells carrying a bicistronic nucleic acid construct comprising a promoter operably linked to a fusion gene associated with chemotherapy-resistant leukemia, and a sequence encoding a reverse tet-transactivator protein, such that both coding sequences are co-expressed from the promoter. Also provided are methods of treating soft tissue cancers. | 10-25-2012 |
20150057164 | HIGH THROUGHPUT METHODS FOR FUNCTIONALLY DETERMINING RNA INTERFERENCE EFFICIENCY - Provided is a single construct combining a sequence encoding an RNAi molecule, a sequence encoding a reporter, and a target sequence specific for the RNAi molecule. The construct can be used to determine the potency of the encoded RNAi molecule in a direct and unbiased way. These results can be used to inform the design of potent RNAi molecules of various types and can be extended to several other applications, including: (1) generation of tiled libraries comprising every possible RNAi molecule-encoding sequence for a given gene target; (2) large-scale parallel validation of RNAi molecules targeting many genes to generate validated RNAi molecule-encoding libraries; (3) experimental comparison of design algorithms and strategies; and (4) investigation of RNAi biology in target site mutagenesis assays by screening pools containing single nucleotide changes in target sites and/or in the RNAi molecule to identify the most relevant sequence characteristics of potent RNAi-target site predictions. | 02-26-2015 |
20150283101 | IDENTIFICATION OF RNAI TARGETS AND USE OF RNAI FOR RATIONAL THERAPY OF CHEMOTHERAPY-RESISTANT LEUKEMIA AND OTHER CANCERS - Provided is a mosaic mouse model for use in determining the potency of an shRNA in vivo for reducing survival of cancer cells of chemotherapy-resistant leukemia. The syngeneic mouse recipient is transplanted with tet-on competent leukemia cells carrying a bicistronic nucleic acid construct comprising a promoter operably linked to a fusion gene associated with chemotherapy-resistant leukemia, and a sequence encoding a reverse tet-transactivator protein, such that both coding sequences are co-expressed from the promoter. Also provided are methods of treating soft tissue cancers. | 10-08-2015 |
Patent application number | Description | Published |
20100241611 | System and method for interactively collaborating within a secure online social networking community - Interactive collaboration within a secure, server-based social networking community integrated with a secured document management system includes at least one of a plurality of professional functionalities and a plurality of integrative functionalities to members having a member virtual identity within the community. Members may assemble into a network of members that excludes at least one member of the community. Integrative functionalities include allowing networks of members to share documents in a remote secured environment and exclude access to documents from those not belonging to a particular network. Members may also access software applications to remotely create, delete, edit and manage documents and view information about documents in a plurality of customizable and selectable viewing options. | 09-23-2010 |
20100241971 | System and method for interactively collaborating within a secure online social networking community - Interactive collaboration within a secure, server-based social networking community integrated with a secured document management system includes at least one of a plurality of professional functionalities and a plurality of integrative functionalities to members having a member virtual identity within the community. Members may assemble into a network of members that excludes at least one member of the community. Integrative functionalities include allowing networks of members to share documents in a remote secured environment and exclude access to documents from those not belonging to a particular network. Members may also access software applications to remotely create, delete, edit and manage documents and view information about documents in a plurality of customizable and selectable viewing options. | 09-23-2010 |
20110066954 | System and method of ranking and searching for professional profiles - A method for searching and ranking professional profiles includes a profile ranking tool that assigns a numeric value to a professional's prestige and competence, called an overall quality score. Different weights are assigned to several different factors that rank a professional based on attributes such as one's peer rating, quality of education, breadth and depth of experience and the quality of work product. | 03-17-2011 |
20110106679 | Method for tagging documents and communications with filing and billing information - A method for tagging documents and communications with filing and billing information in the context of an online social network. As the documents and communication are created an automatic tagging tool associates the created document or communication with a preselected set of information that corresponds to the document or communication, the social network member who made the creation, and the client for whom the work was performed. The information to be associated with each document and communication can be customized to include categories most applicable to the business of the user. | 05-05-2011 |
20110119230 | Method for automatically associating contacts in an online social network - A method for creating and managing contact information in the context of an online social networking community. Each member of the social networking community creates a member profile containing contact information such as email address, telephone numbers, and street addresses. When a member joins a subgroup or secure network within the social networking community, the member's profile is shared with all other members of that secure network. The member's own contacts are also shared with all other members of the network such that one member of the network has access to all contacts of every other member of the network. Contact profiles are automatically updated as the owner of the profile provides new information to his or her profile. Duplicate entries are minimized by a matching feature that alerts members to the creation of possible duplicates and allows the members to merge, delete, or or ignore potential duplicate profiles. Members of a secure network who have shared contact profiles in this manner are able to collaborate on documents and projects within the context of the online social networking community. | 05-19-2011 |
20110213806 | Method for providing alias folders in a document management system - Interactive collaboration within a secure, server-based social community integrated with a secured document management system that includes at least one of a plurality of professional functionalities and a plurality of integrative functionalities to members having a member virtual identity within the community. Members of the community may create a personalized custom set of folders within the document management system, which customized arrangement allows the members to view documents, files, and folders as they desire. By creating these personalized custom “alias” folders, the members rearrange folders to be more accessible to themselves, while leaving the actual files and folders unchanged as viewed by every other member of the community. Members or a network administrator may also grant permission to other members of the network to access alias folders of each other member. | 09-01-2011 |
20120011216 | Method for associating a code with an electronic document, a hard document and storage information relating to the hard document - A system and method for automatically associating hard copy and electronic versions of a document with a code. The electronic version of a document is displayed using an image viewing tool which also displays a code associated with the document. Hardcopies of the electronic document may be printed and will include the same code present in the electronic version of the document. The code linking electronic and hard copy versions of the document provides information relating to each version of the document, such as physical storage location of the hard copy, electronic location of the document, and the identity of members who have recently accessed the document. | 01-12-2012 |
20120036054 | Method for tagging documents and communications with filing and billing information - A method for tagging documents and communications with filing and billing information in the context of an online social network. As the documents and communication are created an automatic tagging tool associates the created document or communication with a preselected set of information that corresponds to the document or communication, the social network member who made the creation, and the client for whom the work was performed. The information to be associated with each document and communication can be customized to include categories most applicable to the business of the user. | 02-09-2012 |
20120084188 | Method for interactively collaborating across online social networking communities - A method for interactively collaborating across several related but independent online social networking communities. Members of each networking communities share a common background or profession, such as being part of the medical, legal or banking industries. Each member has a profile associated with his or her networking community, by which they can interact with other members of the networking community to share contacts, documents, or other productivity functionalities. Members can also interact across networking communities via their networking profile. For example, a doctor who can use his profile from the medical networking community to interact with a lawyer who has a profile on the legal networking community. By promoting cross-community interaction, each group is able to increase their ability to communicate or share ideas and work product via the plurality of networking communities. | 04-05-2012 |
20130254082 | System and method for automatic invoice approval requests - A computer-implemented method for circulating invoices electronically to members of a group so that each relevant member of the group can review the invoice and make changes or add comments the other relevant members of the group, in the context of an online network. When the invoice is ready for review by a member of the group, that member receives a notification on his or her online network homepage. The notification that the invoice is ready for review contains a link to the invoice within the online network, so that each reviewing member can automatically access the invoice through the notification link. As each member of the relevant group completes their review of the invoice, a notification is sent to the next member in a sequence of members selected to review the invoice. | 09-26-2013 |
20130305165 | System and method for folder conduits - The invention provides a digital document management system that incorporates email functionality. The system allows an individual user to share documents and emails with others via a folder conduit system. | 11-14-2013 |
20130332319 | System and method for purchased enabled profiles - The invention provides system and method whereby members of an online community are able to fund their online community member profile accounts, and are able to make purchases using those funds, or credit, which are in or associated with an online community member profile account. | 12-12-2013 |
Patent application number | Description | Published |
20140263456 | CHILD-RESISTANT CLOSURE SYSTEMS FOR CONTAINERS - A child-resistant closure system for a pump sprayer, in one example, includes a cap having a rim at its lower end and including a pair of legs, a dispensing tip configured to receive the cap thereon, the dispensing tip including a pair of finger-depressing shoulders, each shoulder including a slot therein to receive a corresponding leg of the cap therethrough for locking the cap to the dispensing tip, with a cylindrical collar provided beneath the shoulders and including a pair of buttons thereon configured to be simultaneously actuated to release the legs from interior structure within the dispensing tip, and a cylindrical base having its upper end secured to the collar and its lower end secured to a dispenser bottle which contains fluid. | 09-18-2014 |
20140263457 | CHILD-RESISTANT CLOSURE SYSTEMS FOR CONTAINERS - A child-resistant closure system for a pump sprayer includes a protective cap, a dispensing tip having a pair of finger-depressing shoulders, and a cylindrical portion beneath the shoulders, the cylindrical portion including a pair of buttons spaced 180° apart thereon, each button having an undercut formed on a back face thereof. A cylindrical base has its upper end secured to the dispensing tip and its lower end configured to be secured to a dispenser bottle, the dispensing tip and base housing a sprayer pump unit within that is actuated via the shoulders, the base top end including a circular thread formed there around on an external surface thereof. In a locked condition of the dispensing tip, the undercuts engage an underside of the circular thread on the base. Pressing the buttons simultaneously disengages the undercuts from the thread to unlock the dispensing tip and permit sprayer pump unit actuation. | 09-18-2014 |
20140284299 | CHILD-RESISTANT CLOSURE SYSTEMS FOR CONTAINERS - A child-resistant closure system for a container includes an overcap having a pair of levers, each opposite the other and formed into a side facing of the overcap, each lever including a lower vertical member on a rear side thereof, the overcap including a pair of partial threads extending horizontally along an inner surface at the bottom of the overcap, each partial thread 180 degrees from the other, and a cylindrical collar configured to receive the overcap thereon, the collar having an opening configured to receive a dispenser tip and bottleneck of the container therethrough, the collar forming a mechanical bond with the bottleneck, the collar including a neck having a pair of neck threads formed around an external surface thereof, each neck thread 180 degrees apart from the other on the neck, each neck thread terminating at a truncated vertical wall formed on the neck external surface. | 09-25-2014 |
20150320943 | CHILD-RESISTANT CLOSURE SYSTEMS FOR CONTAINERS - A child-resistant closure system for a pump sprayer comprises a cap, a dispensing tip configured to receive the cap thereon, and a base secured to the dispensing tip and secured to a dispenser bottle. The tip has a slot defined therein that comprises a wider insertion/removal portion for inserting or removing a downwardly extending leg and a narrower locking portion for engaging the leg to lock the cap to the dispensing tip. The cap is selectively secured to the dispensing dip by rotating the cap such that the leg moves from the wider portion of the slot to the narrower portion of the slot, such that the narrower portion of the slot engages leg. The leg extends downward through the slot to contact the top of the base so as to allow for the sprayer pump unit to be locked out from operation. | 11-12-2015 |
20150374934 | CHILD-RESISTANT CLOSURE SYSTEMS FOR CONTAINERS - A child-resistant closure system for a container comprises a protective cap, a dispensing tip, and a cylindrical base. The dispensing tip includes a pair of buttons adapted to control whether the dispensing tip is in a locked condition so as to prevent actuation or an unlocked condition so as to permit actuation, via the shoulders, of a sprayer pump unit that is partially contained within the dispensing tip. The cylindrical base has a pair of spaced apart upwardly extending legs. In an locked condition of the dispensing tip, the upwardly extending legs are not aligned with slots defined in a horizontal circumferential portion of the dispensing tip such that downward movement of the dispensing tip in relation to the base is blocked by the upwardly extending legs to prohibit actuation of the sprayer pump unit and to lock the dispensing tip. | 12-31-2015 |