Patent application number | Description | Published |
20100311991 | PROCESS FOR THE PREPARATION OF DOCETAXEL, ITS INTERMEDIATES, AND METHODS FOR PREPARATION THEREOF - The present invention disclosed an process for preparing docetaxel 1, including the following steps: a) hydroxyl acylation reaction of compound 2 and 3 to obtain compound 4; b) deprotection group R | 12-09-2010 |
20110306763 | PROCESS FOR THE PREPARATION OF IMATINIB AND SALTS THEREOF - Disclosed herein is a process for preparation of imatinib free base which comprises condensing 4-Methyl-N-(4-pyridin-3-yl-pyrimidin-2-yl)-benzene-1,3-diamine with 4-(4-Methyl-piperazin-1-ylmethyl)-benzoic acid ester in the presence of base including organic bases and inorganic bases in an organic solvent to form imatinib. | 12-15-2011 |
20130041149 | New Method for Synthesizing Imatinib - In the present invention, a synthesis method of Imatinib is disclosed, which comprises the following steps: the Imatinib, namely 4-(4-methyl-piperazin-1-ylmethyl)-N-[4-methyl-3-[4-(3-pyridinyl)-pyrimidin-2-ylamino]-benzamide shown in formula (III), is formed by reacting 4-methyl-N-3-(4-pyridin-3-yl-pyrimidin-2-yl)-1,3-benzenediamine shown in formula (I) with 4-(4-methyl-piperazin-1-methyl)-benzoic ester shown in formula (II), under the action of a base and in a non-protonic organic solvent, | 02-14-2013 |
20150297727 | SAPONIN NANO MICELLE, PREPARING METHOD, APPLICATION AND PHARMACEUTICAL COMPOSITION THEREOF - A saponin nano micelle, preparing method, application and pharmaceutical composition thereof is disclosed in the present invention. The saponin nano micelle comprises one or more of saponins represented by formula 1, in which, R | 10-22-2015 |
Patent application number | Description | Published |
20110318260 | MANUFACTURE METHOD OF ULTRA-PURE SULFURIC ACID - The present invention provides a method of manufacturing ultra-pure sulfuric acid. Industrial sulfur trioxide is used as the raw material, gasifying it in a round gasifier, getting it gasified for the second time after condensation, sulfur trioxide gas has been purified. Absorbing the sulfur trioxide gas with the dilute sulfuric acid circularly, collect the target product of ultra-pure sulfuric acid. The main content of the ultra-pure sulfuric acid obtained by the method of the present invention can reach more than 96 wt %, the content of the impurities of metal ions is in conformity with the SEMI C12 standard. Furthermore, secondary gasification is applied in the present invention to improve the purity of sulfur trioxide, the purified sulfur trioxide was absorbed by dilute sulfuric acid with different concentration circularly, and overcome the shortcomings, such as the unstable quality of the product which produced in the traditional production methods, the high content of the impurities of metal ions, high energy consumption, high cost and easy to cause pollution, so this invention is more suitable for large-scale continuous production. | 12-29-2011 |
20120067714 | METHOD FOR PRODUCING OF ULTRA-CLEAN AND HIGH-PURITY ELECTRONIC GRADE ACETIC ACID - A method for producing of ultra-clean and high-purity electronic acetic acid is disclosed. The method including following steps: Step 1, industrial acetic acid is fast distilled; Step 2, filtering the fraction by membrane of 0.05˜0.3 μm aperture; Step 3, rectification; Step 4, membrane filtration again. Due to the adoption of the technical scheme above, the ultra-clean and high-purity electronic grade acetic acid which purity is 99.8% is produced. The content of single metal ion is lower than 1 ppb and the content of particulates which is ≧0.5 μm is lower than 5 pcs/ml. The method of the invention will help to reduce energy consumption, to simplify the operation, and to achieve the high security. | 03-22-2012 |
20120141357 | METHOD FOR PRODUCING OF ULTRA-CLEAN AND HIGH-PURITY AQUEOUS HYDROGEN PEROXIDE SOLUTION - The present invention relates to a method for producing of ultra-clean and high-purity aqueous hydrogen peroxide solution. Industrial grade hydrogen peroxide is filtered by SBA-15 molecular sieve with which the chelator is loaded, and then it is further filtered by a hyperfiltration membrane to obtain the ultra-clean and high-purity aqueous hydrogen peroxide solution. The method provided in the present invention overcomes the problems such as complexity of operation, high energy consumption and high content of impurities in the product, and is suitable for continuous production on a large scale because of its simple equipment, simple operation, low energy consumption and stable quality of the product. | 06-07-2012 |
20120145949 | Method for producing electronic grade aqueous ammonium fluoride solution - The present invention relates to a method for producing of electronic grade aqueous ammonium fluoride solution. The industrial grade liquid ammonia is used as the raw material, when it is heated, the ammonia gas will be released. The organic gas impurities in the ammonia gas are removed by activated charcoal, and the oxygen is removed by deoxidizer, and then the high-purity ammonia gas is gotten. The high-purity hydrofluoric acid absorbs and reacts with the high-purity ammonia gas to obtain the electronic grade aqueous ammonium fluoride solution. The product has high-purity and stable quality, and it can be used in producing of electronic products directly. The method for producing of electronic grade ammonium aqueous fluoride solution provided by the present invention is suitable for continuous production on a large scale because of its simple operation. | 06-14-2012 |
20120148482 | METHOD FOR PRODUCING ULTRA-PURE AQUEOUS HYDROGEN PEROXIDE SOLUTION - The present invention provides a method for continuous production of ultra-pure aqueous hydrogen peroxide solution. Industrial grade aqueous hydrogen peroxide solution as raw material is pretreated by macroporous adsorption resin, and then is brought into contact with a cation exchange resin, anion exchange resin to the first ion exchange. Then the material is brought into contact with multi-stage mixed cation and anion exchange resin columns, and is filtered by ultrafilter to obtain ultra-pure aqueous hydrogen peroxide solution. The method provided by the present invention has high security, simple operation, stable quality of product, and is suitable for continuously produce on a large scale. | 06-14-2012 |
Patent application number | Description | Published |
20090001053 | ROUGH MACHING METHOD AND ELECTROEROSION TOOL PERFORMING THE SAME - A rough machining method for machining a channel in a workpiece includes the steps of: provide a power supply to energize one of a workpiece and an electrode as an anode and the other as a cathode; advance the electrode into the workpiece from a first start point to travel a first toolpath, so as to generate a first annular groove with a first core connecting with the workpiece; advance the electrode into the workpiece from a second start point to travel a second toolpath, so as to generate a second annular groove with a second core connecting with the workpiece, wherein the second annular groove intersects with the first annular groove and the first and the second cores are at least partially broken and disconnected with the workpiece upon intersecting of the first and the second annular grooves; and circulating a cutting fluid cross a working gap between a working face of the electrode and the workpiece. | 01-01-2009 |
20100078333 | ELECTROEROSION MACHINING SYSTEM AND METHOD FOR ELECTRODE WEAR COMPENSATION - An electroerosion machining system comprises an electrode, a power supply, an electrolyte supply, an electroerosion controller connected to and monitoring the power supply, and a working apparatus configured to move the electrode relative to the workpiece. The electroerosion machining system further comprises a CNC controller configured to cooperate with the electroerosion controller to control the working apparatus, and to calculate a wear value of the electrode. Further, the CNC controller is configured to segment the toolpath of every layer into a plurality of segments, and to divide the compensation value for every layer to be machined into a plurality of value segments, and further to use the value segments to compensate for electrode wear along the respective toolpath segments during machining of the workpiece. An electroerosion machining method is also presented. | 04-01-2010 |
20100163427 | METHODS AND SYSTEMS FOR ELECTROMACHINING OF A WORKPIECE - An electromachining system is described. The electromachining system includes a computer numerical controller (CNC) device and an electromachining controller device coupled to the CNC device and a power supply. The electromachining system also includes an electromachining tool coupled to the CNC device and the power supply. The electromachining controller device is configured to control operation of the electromachining tool and the CNC device is configured to position the electromachining tool relative to a workpiece. | 07-01-2010 |
20100320078 | ELECTROEROSION SPINDLE ASSEMBLY - An electroerosion spindle assembly includes a main shaft, a tool electrode having a rear end directly or indirectly attached to the shaft and in alignment with the main shaft in a longitudinal direction, a container surrounding the main shaft, a stationary-to-rotary electrical conduction device mounted on the container for transitting power energy to the tool electrode, and a channel routing a flushing fluid to a front end of the tool electrode. The channel has at least one flushing slot in the container. | 12-23-2010 |
20100324720 | MACHINING CONTROL SYSTEM - An electroerosion control system includes a general CNC controller being configured for controlling a general CNC machine process, a power supply for energizing a tool electrode and a workpiece to be machined, an electroerosion controller electrically connecting with the power supply for controlling an output of the power supply, and adaptively and electrically connecting with the general CNC controller for communication thereof, and a sensor sensing real-time status information of a working gap between the tool electrode and the workpiece and for sending said real-time status information to said electroerosion controller. Said electroerosion controller automatically controls the electroerosion machining process through the general CNC controller according to the real-time status information of the working gap. | 12-23-2010 |
20120240386 | TOOL COMPENSATION METHOD AND DEVICE - A Method and machine tool for compensating a wear of an electrode that machines a workpiece. The method includes selecting a current pocket from plural pockets of the workpiece; updating a wear compensation to be applied to the electrode for the current pocket based on wear compensation of a previous pocket, where the previous pocket is adjacent to the current pocket; and applying the updated wear compensation to the electrode for machining the current pocket. | 09-27-2012 |
20130220826 | MACHINING SYSTEMS AND METHODS - A machining system for machining a workpiece is provided. The machining system comprises a machine tool, a plurality of cutting tools, a CNC controller. The plurality of cutting tools comprises an electrode and a conventional cutting tool exchangeably disposed on the machine tool. The machining system further comprises a power supply, a process controller, and an electrolyte supply, wherein the machine tool, the electrode, the CNC controller, the power supply, the process controller and the electrolyte supply are configured to cooperate to function as an electroerosion machining device, wherein the machine tool, the CNC controller, the conventional cutting tool and the electrolyte supply are configured to cooperate to function as a conventional machining device, and wherein the machining system is configured to function alternately as the electroerosion machining device and the conventional machining device. | 08-29-2013 |
Patent application number | Description | Published |
20130324542 | [1,2,4]TRIAZOLO[4,3-B][1,2,4]TRIAZINE COMPOUNDS, PREPARATION METHOD AND USE THEREOF - The present invention relates to a structurally novel [1,2,4]triazolo[4,3-b][1,2,4]triazine compounds represented by formula (I) or formula (II), pharmaceutically acceptable salts thereof, prodrugs thereof, hydrates or solvates thereof, and also relates to a preparation method of the compounds, a pharmaceutical composition including a therapeutically effective amount of the compounds, as well as the use thereof as protein tyrosine kinase inhibitors, particularly as c-Met inhibitors, in the preparation of medicaments for the prevention and/or treatment of diseases associated with c-Met abnormality. | 12-05-2013 |
Patent application number | Description | Published |
20100041844 | RECYCLABLE RUTHENIUM CATALYSTS FOR METATHESIS REACTIONS - The invention relates to novel carbene ligands and their incorporated monomeric and resin/polymer linked ruthenium catalysts, which are recyclable and highly active for olefin metathesis reactions. It is disclosed that significant electronic effect of different substituted 2-alkoxybenzylidene ligands on the catalytic activity and stability of corresponding carbene ruthenium complexes, some of novel ruthenium complexes in the invention can be broadly used as catalysts highly efficient for olefin metathesis reactions, particularly in ring-closing (RCM), ring-opening (ROM), ring-opening metathesis polymerization (ROMP) and cross metathesis (CM) in high yield. The invention also relates to preparation of new ruthenium complexes and the use in metathesis. | 02-18-2010 |
20110172381 | HIGHLY ACTIVE METATHESIS CATALYSTS SELECTIVE FOR ROMP AND RCM REACTIONS - The present invention relates to a kind of novel carbene ligands and ruthenium catalysts, which is highly active and selective for ROMP and RCM reactions, respectively. It discloses the significant electronic and steric effect of different substituted carbene ligands on the catalytic activity and stability of corresponding carbene ruthenium complexes; some of novel ruthenium complexes in the invention can be broadly used as catalysts highly effectively and selective for ROMP and RCM reactions. The invention also relates to preparation of new ruthenium catalysts and the uses in metathesis. Moreover, the invention also provides effective methods of making various functional polymers by ROMP reaction in the presence of new ruthenium catalysts. | 07-14-2011 |
20110183895 | POLYHETEROCYCLIC COMPOUNDS HIGHLY POTENT AS HCV INHIBITORS - The present invention discloses the structure, preparation methods and uses of a series of novel polyheterocyclic based compounds (Ia-Ib and IIa-IIb) that are highly effective for inhibiting hepatitis C virus (HCV): | 07-28-2011 |
20120016093 | RECYCLABLE RUTHENIUM CATALYSTS FOR METATHESIS REACTIONS - The invention relates to novel carbene ligands and their incorporated monomeric and resin/polymer linked ruthenium catalysts, which are recyclable and highly active for olefin metathesis reactions. It is disclosed that significant electronic effect of different substituted 2-alkoxybenzylidene ligands on the catalytic activity and stability of corresponding carbene ruthenium complexes, some of novel ruthenium complexes in the invention can be broadly used as catalysts highly efficient for olefin metathesis reactions, particularly in ring-closing (RCM), ring-opening (ROM), ring-opening metathesis polymerization (ROMP) and cross metathesis (CM) in high yield. The invention also relates to preparation of new ruthenium complexes and the use in metathesis. | 01-19-2012 |
20120252982 | METHODS OF MODIFYING POLYMERS WITH HIGHLY ACTIVE AND SELECTIVE METATHESIS CATALYSTS - The present invention provides methods of depolymerizing and hydrogenating polymers using a transition metal catalyst represented by formula Ia or Ib: | 10-04-2012 |
20140005104 | POLYHETEROCYCLIC COMPOUNDS HIGHLY POTENT AS HCV INHIBITORS | 01-02-2014 |
20140080984 | HIGHLY ACTIVE METATHESIS CATALYSTS SELECTIVE FOR ROMP AND RCM REACTIONS - The present invention relates to a kind of novel carbene ligands and ruthenium catalysts, which is highly active and selective for ROMP and RCM reactions, respectively. It discloses the significant electronic and steric effect of different substituted carbene ligands on the catalytic activity and stability of corresponding carbene ruthenium complexes; some of novel ruthenium complexes in the invention can be broadly used as catalysts highly effectively and selective for ROMP and RCM reactions. The invention also relates to preparation of new ruthenium catalysts and the uses in metathesis. Moreover, the invention also provides effective methods of making various functional polymers by ROMP reaction in the presence of new ruthenium catalysts. | 03-20-2014 |
20140205567 | Macrocyclic Heterocyclic Compound for Inhibiting Hepatitis C Virus and Preparation and Use Thereof - The present invention discloses a class of novel macro-heterocyclic compounds represented by the formula Ia or Ib, and their intermediates, preparation methods and the uses. The macro-heterocyclic compounds of the present invention have good inhibitory activities against hepatitis C virus (HCV), and can be used to treat HCV infection effectively by its excellent inhibition against HCV, low toxicity and side effects. | 07-24-2014 |