Yuzhakov
Alexander Yuzhakov, Bronx, NY US
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20110230407 | HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN DEMYELINATING DISEASES AND CENTRAL NERVOUS SYSTEM TRAUMA - Methods are provided for treating and preventing demyelinating diseases including multiple sclerosis, and traumatic injury to the central nervous system including brain trauma and spinal cord injury, by administering a compound or pharmaceutical composition of the invention. Useful compounds include hepatocyte growth factor/scatter factor protein, fragments, fusion polypeptides and muteins thereof, and nucleic acid and expression vectors encoding such proteins. Other useful compounds include small molecule HGF/SF agonists and mimetics. | 09-22-2011 |
Alexander Yuzhakov, West Roxbury, MA US
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20090017108 | Liposome compositions for treatment of hepatitis C - In the present invention compositions and methods are described for treating patients with a hepatitis C viral infection typically using interferon-alpha and/or ribavirin which are incorporated into liposomes, wherein the liposomes typically contain at least one carbohydrate moiety on the surface, such as a mono-, di-, oligo-, or polysaccharide moiety or any combination thereof, for targeting to hepatocytes. Other liposome surface modifications are provided to enhance effectiveness of the compound(s) therein. | 01-15-2009 |
20100291575 | Detection of Changes in Cell Populations and Mixed Cell Populations - The invention provides methods of label-free detection of changes in cell populations and mixed cell populations. | 11-18-2010 |
20110237535 | Use of Induced Pluripotent Cells and other Cells for Screening Compound Libraries - The invention provides methods for screening test compounds or toxins for effects on cells. The invention also provides methods for determining frequency, amplitude and kinetic profiles of cells. | 09-29-2011 |
20120058507 | Clonal Derivation and Cell Culture quality Control Screening Methods - The invention provides methods of label-free detection of changes in cell populations and mixed cell populations. | 03-08-2012 |
20120107840 | Methods for Label Free Testing of Cells - The invention provides methods of detecting activation of an immune cell, methods for detecting blocking or enhancing properties of a test reagent or stimuli on activation of one or more immune cells or platelets, methods for selecting hybridomas producing antibodies to an antigen for quality of strength of binding to the antigen, methods for determining if a subject has had an immune response to an immunogen, methods of isolating neutralizing antibodies for an immunogen, methods of classifying a B cell lymphoma, and methods for selecting activated B-cells expressing an antibody to one or more antigens. | 05-03-2012 |
Alexey V. Yuzhakov, Novosibirsk RU
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20160041866 | PROCESSING RUN-TIME ERROR MESSAGES AND IMPLEMENTING SECURITY POLICIES IN WEB HOSTING - A user administers web hosting on user's server from his computer remotely. When a run time error is generated, an error message is sent to a server connected to a knowledge database. If the error matches the known error form the knowledge database, the user is provided an article with a solution to the run-time error. Statistics of occurrence of the errors are saved in the knowledge database. The frequently occurring errors are provided to developers for creating hosting application updates. Additionally, security policies of the user's server can be updated based on the data from the knowledge database. | 02-11-2016 |
Evgeny Yuzhakov, Saint Petersburg RU
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20110244878 | Identifying and Displaying User Status Information - A method identifies multiple contacts associated with a user, where the user and the multiple contacts are associated with a common mobile service. A relationship is defined between the user and each of the multiple contacts by the common mobile service. Each of the multiple contacts is monitored automatically by the common mobile service to obtain user information. A mobile device associated with the user displays the current user information associated with at least a portion of the multiple contacts. | 10-06-2011 |
Vadim Yuzhakov, Alameda, CA US
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20090099437 | Lancing Depth Adjustment Via Moving Cap - A lancing device includes a housing for containing a lancet. A lancet driver couples with and moves the lancet within the housing. A skin interface cap has an opening defined therein to expose at least part of the lancet when moved by the driver. A sliding frame is coupled to the housing and to the skin interface cap. The frame being adjustable relative to the housing for accordingly adjusting said cap relative to the housing, whereby an extent to which the lancet is exposed through the opening is adjustable by adjusting the sliding frame. | 04-16-2009 |
Vadim V. Yuzhakov, Alameda, CA US
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20100130940 | METHOD OF MAKING MICRONEEDLE ARRAY AND DEVICE FOR APPLYING MICRONEEDLE ARRAY TO SKIN - Microneedle arrays and drug delivery devices are provided for transdermally delivering a drug formulation to a patient. The microneedle array device includes a substantially planar substrate having an array of apertures; and a plurality of microneedles projecting at angle from the planar substrate, the microneedles having a base portion integrally connected to the substrate, a tip end portion distal to the base portion, and body portion therebetween, wherein each microneedle has at least one channel extending substantially from the base portion through at least a part of the body portion, the channel being open along at least part of the body portion and in fluid communication with at least one of the apertures in the substrate. In a preferred embodiment, each microneedle has a substantially rectangular cross-sectional shape and the channel is open to two opposing surfaces of the microneedle. | 05-27-2010 |
20100305473 | TISSUE CONFORMING MICRONEEDLE DEVICE FOR DRUG DELIVERY OR BIOLOGICAL FLUID COLLECTION - Microneedle arrays are provided for use on a contoured or flexible tissue surface. In one embodiment, the microneedle array includes a plurality of microneedles, each having a base portion, a tip end portion distal to the base portion, and body portion therebetween; and a flexible substrate which comprises a plurality of apertures, each of which are defined by (i) a plurality of substrate elements which are integral with the base portions of the microneedles, and (ii) at least one spring element connecting at least two of the substrate elements. The spring element may include a curved element, such as a C-shaped, U-shaped, or S-shaped element. Apertures may be defined, for example, by two substrate elements, which connected to three or four spring elements. A skin patch is provided for therapeutic or diagnostic applications, which includes the microneedle array and an adhesive material. | 12-02-2010 |
Vadim V. Yuzhakov, Sunnyvale, CA US
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20130218083 | DEVICE FOR APPLYING MICRONEEDLE ARRAY TO SKIN - Microneedle arrays and drug delivery devices are provided for transdermally delivering a drug formulation to a patient. The microneedle array device includes a substantially planar substrate having an array of apertures; and a plurality of microneedles projecting at angle from the planar substrate, the microneedles having a base portion integrally connected to the substrate, a tip end portion distal to the base portion, and body portion therebetween, wherein each microneedle has at least one channel extending substantially from the base portion through at least a part of the body portion, the channel being open along at least part of the body portion and in fluid communication with at least one of the apertures in the substrate. In a preferred embodiment, each microneedle has a substantially rectangular cross-sectional shape and the channel is open to two opposing surfaces of the microneedle. | 08-22-2013 |