Yuan Tian
Yuan Tian, Alameda, CA US
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20090258048 | Self-Assembling Monomers and Oligomers as Surface-Modifying Endgroups for Polymers - Polymers having the formula R(LE) | 10-15-2009 |
20100113711 | CONTROL OF POLYMER SURFACE MOLECULAR ARCHITECTURE VIA AMPHIPATHIC ENDGROUPS - Polymers whose surfaces are modified by endgroups that include amphipathic surface-modifying moieties. An amphipathic endgroup of a polymer molecule is an endgroup that contains at least two moieties of significantly differing composition, such that the amphipathic endgroup spontaneously rearranges its positioning in a polymer body to position the moiety on the surface of the body, depending upon the composition of the medium with which the body is in contact, when that re-positioning causes a reduction in interfacial energy. An example of an amphipathic surface-modifying endgroup is one that has both a hydrophobic moiety and a hydrophilic moiety in a single endgroup. For instance, a hydrophilic poly(ethylene oxide) terminated with a hydrophilic hydroxyl group is not surface active in air when the surface-modifying endgroup is bonded to a more hydrophobic base polymer. If the hydroxyl group on the oligomeric poly(ethylene oxide) is replaced by a hydrophobic methoxy ether terminus, the poly(ethylene oxide) becomes surface active in air, and allows the poly(ethylene oxide) groups to crystallize in the air-facing surface. In this example, immersion in water destroys the crystallinity as the poly(ethylene oxide) sorbs water and the hydrophobic methoxy group retreats below the surface of the polymer. Also disclosed are methods and articles of manufacture that make use of these polymers. | 05-06-2010 |
20100179284 | POLYMERS WITH BIO-FUNCTIONAL SELF ASSEMBLING MONOLAYER ENDGROUPS FOR THERAPEUTIC APPLICATIONS AND BLOOD FILTRATION - Medical device, prosthesis, or packaging assembly made up of polymer body comprising at least one polymer having the formula R(LE)x wherein R is a polymeric core having a number average molecular weight of from 5000 to 7,000,000 daltons, and having x endgroups, x is an integer≧1, E is an endgroup which is covalently linked to polymeric core R by linkage L, L is a divalent oligomeric chain which has at least 5 repeat units and which can self-assembly with L chains on adjacent molecules of the polymer, and moieties L and/or E in the polymer(s) may be the same as or different from one another in composition and/or molecular weight. The polymer body includes plural polymer molecules located internally within the body, at least some of which internal polymer molecules have endgroups that form a surface of the body. The surface endgroups include at least one self-assembling moiety. | 07-15-2010 |
20110028661 | HYBRID POLYURETHANE BLOCK COPOLYMERS WITH THERMOPLASTIC PROCESSABILITY AND THERMOSET PROPERTIES - Block copolymers are formulated with multifunctional chain extenders. The block copolymers include a soft segment and a hard segment made from a diisocyanate, an alkylene diamine chain extender, and a multifunctional chain extender which provides delayed crosslinking. The multifunctional chain extenders have a functionality and typically have at least one OH group. The multifunctional chain extenders may be aliphatic or aromatic triols or polyols, or may have other configurations, as described. The resulting block copolymers have improved mechanical properties such as compression set. They may be used in medical applications, or in industrial applications such as seal and gasket applications, including O-rings, window seals, and automotive gaskets. The initially-formed polyurethane resin behaves as a thermoplastic processable material, while the configured end-use product is thermoset. | 02-03-2011 |
20110086077 | SILICONE HYDROGELS FOR TISSUE ADHESIVES AND TISSUE DRESSING APPLICATIONS - A silicone hydrogel formulation may contains random and/or block copolymers or oligomers or macromers. The silicone copolymer is copolymerized or blended with other polymers or monomers or macromers to obtain final formulation. The silicone hydrogel may contain crosslinking groups to provide a complete or partially crosslinked final structure. The silicone hydrogel formulation may be pre-formed as a film or other structure, or it may be polymerized during application as in the case of an adhesive formulation. A wound dressing comprising a silicone hydrogel formed as a film, either prior to application to a wound or in situ on a wound, which film has gas permeability, moisture permeability, and high water content, wherein said silicone hydrogel is formed from a polymerizable silicone such as a difunctional polydimethylsiloxane methacrylate and crosslinking agents such as N,N-dimethyllacrylamide (DMA), 2-hydroxyethyl methacrylate (HEMA), and trimethylsiloxy silane (TRIS). | 04-14-2011 |
20110124772 | ANTIMICROBIAL POLYMERS AND THEIR USES - Polymers with non-leaching antimicrobial activity and their use as surface coatings or bulk resins for medical devices. The antimicrobial polymers are prepared with antimicrobial moieties covalently bonded to a polymer chain end or to a polymer backbone at a side chain end. The antimicrobial moiety-containing endgroups include surface active (or surface assembling) moieties which promote enrichment of antimicrobial endgroups at the polymer surface and thus formation of an antimicrobially active surface. Polymers with built-in antimicrobial endgroups can be used as bulk resins, as antimicrobial additives, or as infection preventative coatings in the manufacture of medical devices (e.g., catheters, vascular access devices, peripheral lines, IV sites, drains, gastric feeding and tubes, and other implantable devices). Such materials can also be used as antimicrobial and antifouling coatings on structures in contact with microorganism in environments that require control of biofilm formation, such as marine products. | 05-26-2011 |
20110207897 | IONOMERS FOR IMPROVED COMPRESSION SET IN CERTAIN COPOLYMERS - Block copolymer having improved compression set comprising 40-98 wt-% soft segment, 1.9-20 wt-% hard segment, and 0.05-3 wt-% monofunctional ionic endgroups. The incorporation of ionomers into diisocyanate-based thermoplastic polyurethane materials greatly improves compression set with little impact on the overall TPU formulation. A typical formulation for making the block copolymer contains 84.2% polydimethylsiloxane, 12.9% diisocyanate, 2.9% diamine chain extender, 0.15% sodium 2-[bis(2-hydroxyethyl)amino]ethylsulfonate, and 0.05% isethionic acid. The polymeric material may be configured, for instance, as a contact lens, prosthetic spinal nucleus, orthopedic bearing surface, gasket, or sealant. | 08-25-2011 |
20110293522 | SURFACE MODIFICATION OF POLYMERS VIA SURFACE ACTIVE AND REACTIVE END GROUPS - Polymer surface modification method comprising the steps of first forming a surface of primary reactive end groups tethered to the polymer chain ends during fabrication of an article, and then modifying the reactive surface with bio-active molecules, hydrophilic and hydrophobic monomers, oligomers, or polymers to attain specific surface properties. Alternatively, a multifunctional coupling agent can be used to couple the primary reactive group to a second reactive group capable of reacting with a functional group associated with bio-active molecules, hydrophilic and hydrophobic monomers, oligomers, and polymers to attain specific surface properties. The invention involves bringing reactive endgroups to the surface with surface active spacer attached to the polymer chain end. The surface active spacer allows the migration and enrichment of reactive end groups to the surface during fabrication. The invention provides medical devices having a bio-interface with anti-thrombogenic properties, lubricity, selective adsorption, and antimicrobial properties. | 12-01-2011 |
20120095166 | SELF-ASSEMBLING MONOMERS AND OLIGOMERS AS SURFACE-MODIFYING ENDGROUPS FOR POLYMERS - Polymers having the formula R(LE) | 04-19-2012 |
20120136087 | PHOSPHORYLCHOLINE-BASED AMPHIPHILIC SILICONES FOR MEDICAL APPLICATIONS - Amphiphilic biomimetic phosphorylcholine-containing silicone compounds for use in both topical and internal applications as components in biomedical devices. The silicone compounds, which include zwitterionic phosphorylcholine groups, may be polymerizable or non-polymerizable. Specific examples of applications include use as active functional components in ophthalmic lenses, ophthalmic lens care solutions, liquid bandages, wound dressings, and lubricious and anti-thrombogenic coatings. | 05-31-2012 |
20140135408 | SILICONE CONTAINING MONOMERS WITH HYDROPHILIC END GROUPS - Silicone containing reactive monomers with hydrophilic end-groups of formula I useful in the manufacture of biocompatible medical devices are disclosed, wherein R | 05-15-2014 |
20140350184 | SURFACE MODIFICATION OF POLYMERS VIA SURFACE ACTIVE AND REACTIVE END GROUPS - Polymer surface modification method comprising the steps of first forming a surface of primary reactive end groups tethered to the polymer chain ends during fabrication of an article, and then modifying the reactive surface with bio-active molecules, hydrophilic and hydrophobic monomers, oligomers, or polymers to attain specific surface properties. Alternatively, a multifunctional coupling agent can be used to couple the primary reactive group to a second reactive group capable of reacting with a functional group associated with bio-active molecules, hydrophilic and hydrophobic monomers, oligomers, and polymers to attain specific surface properties. The invention involves bringing reactive endgroups to the surface with surface active spacer attached to the polymer chain end. The surface active spacer allows the migration and enrichment of reactive end groups to the surface during fabrication. The invention provides medical devices having a bio-interface with anti-thrombogenic properties, lubricity, selective adsorption, and antimicrobial properties. | 11-27-2014 |
Yuan Tian, Beijing CN
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20100310605 | ANTI-HCV VACCINE AND PREPARATION METHODS AND USES THEREOF - An anti-HCV vaccine, which is prepared through recombination of an NS gene in series, including NS3/NS4 and NS4/NS5, with an adenovirus vector. The preparation methods and uses of the anti-HCV vaccine. | 12-09-2010 |
20140282920 | DYNAMICALLY SELECTING A DHCP SERVER FOR A CLIENT TERMINAL - Dynamically selecting a DHCP server for a DHCP client terminal device, according to an example, includes: triggering, by a network device with a DHCP relay function, an authentication performed by an authentication server on a DHCP client terminal device user when receiving a DHCP packet for requesting a configuration parameter sent from a DHCP client terminal device; receiving, by the network device, an identity of a DHCP server designated by the authentication server for the DHCP client terminal device user when the DHCP client terminal device user passes the authentication, and establishing an entry for user information of the DHCP client terminal device user and the identity of the designated DHCP server; and matching, by the network device, the user information carried in a packet with established entries when receiving the packet subsequently sent from the DHCP client terminal device, and forwarding the packet using the identity of the DHCP server in the entry matching the user information. | 09-18-2014 |
Yuan Tian, New York, NY US
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20100285988 | Gamma-Secretase Substrates And Methods Of Use - Polypeptide substrates based on modifications or fragments of the various APP isoforms, assay methods based on the use of these substrates, and screening methods directed toward identifying inhibitors of γ-secretase activity. The assay methods and the screening methods are adapted for use in high throughput multi-well plate assay apparatuses. In many embodiments the substrate polypeptides are labeled for ease of detection, and/or may bind specific ligands that themselves are labeled. Generally the labels promote high specificity as well as high sensitivity of detection. These features render the assay and screening methods that employ the labeled substrates especially suited for use in high throughput assay formats. This disclosure further identifies small polypeptides based on a subsequence motif of Aβ that are shown herein to be potent inhibitors of the activity of γ-secretase. | 11-11-2010 |
20110143954 | GAMMA-SECRETASE SUBSTRATE AND METHODS OF USE - Polypeptide substrates based on modifications or fragments of the various APP isoforms, assay methods based on the use of these substrates, and screening methods directed toward identifying inhibitors of γ-secretase activity. The assay methods and the screening methods are adapted for use in high throughput multi-well plate assay apparatuses. In many embodiments the substrate polypeptides are labeled for ease of detection, and/or may bind specific ligands that themselves are labeled. Generally the labels promote high specificity as well as high sensitivity of detection. These features render the assay and screening methods that employ the labeled substrates especially suited for use in high throughput assay formats. This disclosure further identifies small polypeptides based on a subsequence motif of Aβ that are shown herein to be potent inhibitors of the activity of γ-secretase. | 06-16-2011 |
20110257027 | GAMMA-SECRETASE SUBSTRATE AND METHODS OF USE - Polypeptide substrates based on modifications or fragments of the various APP isoforms, assay methods based on the use of these substrates, and screening methods directed toward identifying inhibitors of γ-secretase activity. The assay methods and the screening methods are adapted for use in high throughput multi-well plate assay apparatuses. In many embodiments the substrate polypeptides are labeled for ease of detection, and/or may bind specific ligands that themselves are labeled. Generally the labels promote high specificity as well as high sensitivity of detection. These features render the assay and screening methods that employ the labeled substrates especially suited for use in high throughput assay formats. This disclosure further identifies small polypeptides based on a subsequence motif of Aβ that are shown herein to be potent inhibitors of the activity of γ-secretase. | 10-20-2011 |
Yuan Tian, Mountain View, CA US
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20090067449 | Integrated system and method for interactive communication and multimedia support in vehicles - An integrated system for interactive communication and multimedia support in a vehicle. The system includes a plurality of peripheral devices and a central control unit. Each of the peripheral devices is configured to be installed in the vehicle. The central control unit is also configured to be installed in the vehicle and has a communication interface. The communication interface includes first and second communication platforms and communicates with the plurality of peripheral devices via at least one of the first and second communication platforms. Each communication platform is configured to support bi-directional and selective communication between each of the peripheral devices. | 03-12-2009 |
20100091756 | METHOD OF USING ACKNOWLEDGMENT TONES FOR DATA CONSISTENCY IN INTRA-VEHICULAR WIRELESS NETWORKS - A method for providing electronic communications between wireless nodes includes wirelessly transmitting data from a transmitting one of the nodes to a plurality of receiving ones of the nodes. A respective first acknowledgment tone is wirelessly transmitted from each of the receiving nodes to the transmitting node and to each other one of the receiving nodes. Each first acknowledgment tone is transmitted in response to the respective receiving node receiving the transmitted data. Each of the first acknowledgment tones is transmitted in a respective, unique time slot. At least one second acknowledgment tone is wirelessly transmitted from at least one of the nodes to each other one of the nodes. The second acknowledgment tone is transmitted dependent upon whether a group of received first acknowledgment tones matches a group of expected-to-be-received first acknowledgment tones. | 04-15-2010 |
20100158243 | METHOD OF ENCRYPTION IN NETWORKED EMBEDDED SYSTEMS - A data encryption method includes providing a sender node having information to transmit. The information is divided into a sequence of frames. A respective one of a plurality of frame numbers is assigned to each of the frames. At least one nonce and at least one security key are used to perform block cipher encryption and produce within the sender node a respective block cipher encryption output for each of the frames. The information is converted from a sequence of plaintext frames to a sequence of ciphertext frames by use of the block cipher encryption outputs produced within the sender node. The converting is performed within the sender node and after the block cipher encryption outputs have been produced within the sender node. A receiver node is used to ascertain the frame numbers. The at least one nonce is transmitted from the sender node to the receiver node. The at least one nonce and the at least one security key are used to perform block cipher encryption and produce within the receiver node a respective block cipher encryption output for each of the frames. The ciphertext frames are transmitted from the sender node to the receiver node. The ciphertext frames are transmitted after the block cipher encryption outputs have been produced within the receiver node. The transmitted ciphertext is converted back into the plaintext frames by use of the block cipher encryption outputs produced within the receiver node. The converting is performed within the receiver node and after the block cipher encryption outputs have been produced within the receiver node. | 06-24-2010 |
Yuan Tian, Shanghai CN
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20120204971 | SYSTEM AND METHOD FOR COMPRESSED GAS FUEL HANDLING - A system includes a cooler configured to cool a first gas portion of a compressed gas fuel and discharge a cooled fluid. The cooled fluid comprises a cooled gas portion and a cooled liquid portion. The system also includes a separator configured to separate the cooled fluid into the cooled gas portion and the cooled liquid portion and a mixing tank configured to mix a second gas portion of the compressed gas fuel with the cooled gas portion in direct contact with one another to produce a superheated gas fuel. The superheated gas fuel comprises a degree of superheat above a lower threshold for a combustion system. | 08-16-2012 |
Yuan Tian, Newton, MA US
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20120208844 | SUBSTITUTED PIPERIDINES THAT INCREASE P53 ACTIVITY AND THE USES THEREOF - The present invention provides a compound of Formula (1) as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same. | 08-16-2012 |
20140315916 | MACROCYCLES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF - The present invention provides a compound of Formula (1): as described herein or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same. | 10-23-2014 |
20140323482 | SUBSTITUTED PIPERIDINES AS HDM2 INHIBITORS - The present invention provides a compound of Formula I (The formula should be inserted here) as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same. | 10-30-2014 |
20140336222 | SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF - The present invention provides a compound of Formula 1 | 11-13-2014 |
Yuan Tian, Baltimore, MD US
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20140106369 | BIOMARKERS FOR AGGRESSIVE PROSTATE CANCER - The present invention relates to the field of biomarkers and, more specifically, to biomarkers useful in diagnosing aggressive prostate cancer. In specific embodiments, a method for diagnosing aggressive prostate cancer in a patient comprises (a) measuring the levels of one or more biomarkers in a sample collected from the patient; and (b) comparing the levels of the one or more biomarkers with predefined levels of the same biomarkers that correlate to a patient having aggressive prostate cancer and predefined levels of the same biomarkers that correlate to a patient not having aggressive prostate cancer, wherein a correlation to one of the predefined levels provides the diagnosis. In a specific embodiment, the one or more biomarkers may comprise cathepsin-L (CTSL), periostin, microfibrillar-associated protein 4 (MFAP4), collagen XII, neprilysin, clusterin, neutrophil gelatinase associated lipocalin (NGAL), epithelial cell activating molecule (EpCAM), prostate specific antigen (PSA), membrane metallo-endopeptidase (MME) and asporin (ASPN). | 04-17-2014 |
Yuan Tian, Fremont, CA US
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20130171939 | LOW COST PROXIMITY PAIRING MECHANISM IN WIRELESS PERSONAL AREA NETWORKS - A wireless networking method includes placing a master device and at least one peripheral device within proximity of each other. A radio frequency request for proximity pairing is transmitted from the peripheral device to the master device. Radio frequency proximity pairing signals implementing the proximity pairing are transmitted from the master device to the peripheral device. The proximity pairing signals are transmitted with a first level of transmission power. After the proximity pairing is complete, operational signals are transmitted from the master device to the peripheral device. The operational signals are transmitted with a second level of transmission power greater than the first level of transmission power. | 07-04-2013 |
Yuan Tian, Hefei CN
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20150082783 | ENERGY REGENERATION TYPE FORKLIFT HYDRAULIC SYSTEM - An energy regeneration type forklift hydraulic system is provided, which includes a first oil pump, a first electrical motor, a multiple directional control valve, a lifting oil cylinder, a tilting oil cylinder, a steering oil cylinder, a load-sensing steering device, an oil filter, a second oil pump and an oil tank, wherein the multiple directional control valve includes an oil inletting and returning valve spool, a raising and lowering reversing valve spool, a tilting reversing valve spool, and an oil inletting valve spool. The raising and lowering reversing valve spool includes a raising and lowering three-position six-way reversing valve, an annular oil returning passage and an oil returning passage. The system can utilize the potential energy of lowering cargo to simultaneously drive two oil pumps for driving two motors to generate energy, thereby realizing energy recovery. | 03-26-2015 |
Yuan Tian, Shenzhen CN
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20150110053 | METHOD AND APPARATUS FOR SCHEDULING USER DATA - Embodiments of the present invention provide a method and an apparatus for scheduling user data, and the method includes: acquiring a power limitation manner in which power limitation is implemented on user data of a user; acquiring an actual scheduling weight of the user after the power limitation is implemented in accordance with the power limitation manner; and transmitting the user data of the user on a resource block according to the actual scheduling weight of the user. This method combines different power limitation manners with scheduling criteria and updates the scheduling weight according to the power limitation manner, so that a scheduling result is more in line with a channel state, and system performance is improved. | 04-23-2015 |
20150155966 | OPEN-LOOP LINK ADAPTION ADJUSTING METHOD AND APPARATUS - Embodiments of the present invention disclosed an open-loop link adaptation adjusting method and apparatus, firstly, classifying, by a base station, states of a user equipment during an information transmission process, and configuring an open-loop link adaptation adjusting OLLA value for each of the classified states respectively; then, determining, by the base station, a current state of the user equipment, and selecting an OLLA value corresponding to the current state of the user equipment from the OLLA values corresponding to each of the states respectively; and finally, after adjusting a modulation and coding scheme MCS value according to the OLLA value corresponding to the current state of the user equipment, modifying, by the base station, the OLLA value corresponding to the current state of the user equipment. The present invention is applicable to the communication system field. | 06-04-2015 |
Yuan Tian, Gansu CN
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20150213163 | PARTICLE FLOW SIMULATION SYSTEM AND METHOD - The present invention provides a GPU-based particle flow simulation system and method which includes generating particle information based on particle modeling information inputted from a client terminal, and generating geometric solid information; receiving the particle information and the geometric solid information, determining which GPUs of which computation nodes are to be used based on the number of the particles and the number of idle GPUs in each of the computation nodes; determining which particles are to be processed in which GPUs of which computation nodes based on the determined number of GPUs and a space distribution of the particles, and performing allocation according to the determination result; stimulating particle flow by computing in parallel in the plurality of GPUs a force applied to each particle due to particle collision and thus an acceleration; and presenting a stimulation result. The embodiments of the present invention can implement a virtual experimental simulation of high-density particles, and improve computation efficiency while reducing power consumption. | 07-30-2015 |
Yuan Tian, Boston, MA US
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20150218096 | 4-HETEROARYL SUBSTITUTED BENZOIC ACID COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF - The present invention relates to compounds according to Formula I (Formula I), and pharmaceutically acceptable salts or solvates thereof. Such compounds can be used in the treatment of RORgammaT-mediated diseases or conditions. | 08-06-2015 |