Patent application number | Description | Published |
20090131810 | Breath test device and method - There is provided a method of evaluating a liver condition of a subject, the method includes computing a fluctuation parameter from a liver breath test based on at least one of a percentage dose recovery (PDR) curve and a delta over baseline (DOB) curve of an isotope labeled methacetin, or a salt or a derivative thereof, and evaluating at least one liver condition of the subject, based at least on the fluctuation parameter. There is provided herein a method of evaluating a liver condition of a subject, the method includes computing a hepatic impairment score based at least on a breath test related parameter and on a demographic parameter. | 05-21-2009 |
20100016412 | INHIBITION OF ORNITHINE AMINOTRANSFERASE FOR THE TREATMENT OF PROLIFERATIVE DISORDERS - The invention relates to inhibition of ornithine aminotransferase (OAT) for suppression of tumor cells proliferation. More particularly, the invention relates to methods of treatment of proliferative disorders by the selective inhibition of OAT, and further provides the use of OAT inhibitors, specifically, 5-amino-1,3-hexadienyl-carboxylic acid (Gabaculine), and Gabaculine analogue 8, for compositions and methods for the treatment of proliferative disorders such as hepatocellular carcinoma. The invention further provides methods and kits for the diagnosis of a pathologic proliferative disorder in a mammalian subject, based on determining the level of OAT expressed in a biological sample obtained from a subject. | 01-21-2010 |
20100021500 | Processes for treating subjects carrying viral infectious agent - This invention provides novel processes for therapeutic applications, including the treatment of subjects carrying infectious agents or having impaired autoimmunity or impaired immune condition. The therapeutic applications disclosed herein are also directed at the treatment of cancerous subjects with malignant tumors containing cancerous cells or malignant or cancerous cells. Vaccination processes for preventing infections in subjects are also provided. The novel processes comprise introducing into or adminstering to a subject one or more antigens, or trained or adopted immune cells. These antigens or immune cells are capable of establishing or increasing at least one first specific immune response and decreasing at least one second specific immune response. Such responses include components, such as cellular immune reaction elements, humoral immune reaction elements and cytokines, the latter also encompassing interferons and lymphokines. Useful compositions are also provided by this invention. | 01-28-2010 |
20100036273 | Breath Test Device and Method - The disclosure relates breath test devices and methods for the evaluation of liver functional and metabolic capacity or to assess liver heath and/or degree of liver injury. Specifically, there is provided a method of evaluating a liver condition, the method includes on-line monitoring a metabolic product of methacetin, a salt or a derivative of methacetin, in a subject's breath after administering to the subject isotope labeled methacetin, a salt or a derivative thereof in water solution form. There is also provided a device for evaluating a liver condition, the device includes one or more sensors adapted to monitor on-line an isotope level of a metabolic product of labeled methacetin, or a salt or a derivative of methacetin in a subject's breath and a controller adapted to sample measurements of the one or more sensors at a continuous mode. | 02-11-2010 |
20100247652 | Alginate Biomaterials for the Treatment of Hepatic Disorders - The present invention relates to methods for the treatment of hepatic disorders in a subject in need thereof. More specifically, the methods of the invention are based on the administration, preferably, systemic administration, of a therapeutically effective amount of at least one biocompatible alginate biomaterial, any modification thereof and any combination thereof. The invention further provides methods for sustaining serum albumin levels, and/or reducing serum AST and ALT, in subjects suffering from hepatic disorder. Still further, the invention provides methods for reducing apoptosis and inducing cell proliferation in a damaged liver tissue of a subject suffering of hepatic disorder, using the alginate biomaterial described by the invention. | 09-30-2010 |
20100249048 | BETA GLYCOLIPIDS FOR THE TREATMENT OF CALCIFICATION RELATED DEGENERATIVE DISORDERS - The present invention relates to a composition comprising a combination of at least one natural or synthetic β-glycolipid, a mixture of at least two β-glycolipids, a substance which increases the intracellular, extracellular or serum level of a naturally occurring β-glycolipid, or any combination or mixture thereof and at least one phosphate inhibitor or any compound that alters the phosphate binding or transporting into or out of any cell or any membrane or any combination thereof. The combined composition of the invention may be particularly used for treating calcification related degenerative disorders, specifically, vascular and valvular disorders. The invention further provides kits methods and uses thereof for treatment of calcification related disorders. | 09-30-2010 |
20100268040 | METHOD AND SYSTEM FOR DETECTION OF PRE-FAINTING AND OTHER CONDITIONS HAZARDOUS TO THE HEALTH OF A PATIENT - Included herein are embodiments relating to detecting and warning of the presence of pre-fainting and other conditions that may be hazardous to the health of a patient having one or more types of disease or disorder. A wide range of physiological and physical parameters can be monitored and logically and/or mathematically related to determine the value of a new parameter, the risk parameter alpha. The parameters that appear in the function can be selected according to the patient's known pathological condition. An initial threshold value for alpha can be determined and compared with a current value of alpha. If the comparison shows that there exists danger of the onset of a pre-fainting and/or other medically hazardous condition, a warning signal can be emitted. The current value of alpha can be continually determined and, if relevant, updated according to the history of the patient. | 10-21-2010 |
20110200610 | Immuno-Modulating Compositions for the Treatment of Immune-Mediated Disorders - The present invention relates to immunomodulatory compositions comprising mammalian colostrum-derived immunoglobulin preparation and optionally further colostrums, milk or milk product component/s and any adjuvants for treating immune-related disorders. More specifically, the invention provides compositions comprising colostrum-derived anti-insulin immunoglobulin preparations for the treatment of Metabolic Syndrome. The invention further provides methods and uses of the immunomodulatory compositions for an active or passive immunization in a disease-antigen specific or non specific manner. | 08-18-2011 |
20110200617 | COMBINATION THERAPY OF BETA-GLYCOLIPIDS AND ANTIBODIES FOR THE TREATMENT OF IMMUNE-RELATED DISORDERS - The present invention relates to a combination therapy for the treatment of immune-related disorders. More particularly, the invention relates to oral or mucosal synergistic compositions combining beta-glycolipids, preferably, β-glycosphingolipids with immunoglobulin molecules specific for at least one antigen derived from a component of the immune system, specifically an anti-CD3 antibody. The invention further provides methods kits and uses of the combined compositions of the invention for immuno-modulation and thereby for the treatment of immune-related disorders. In a preferred embodiment, anti-CD3 anti-body (OKT3) is orally administered in combination with β-glucosylceramide (also known as glycocerebroside) in an animal model of type 2 diabetes. | 08-18-2011 |
20110236438 | METHOD OF TREATMENT OF DISEASES USING HOODIA EXTRACTS - A method for treating a disease comprising administering to a mammal in need thereof an effective dosage of an extract of a plant of the genus | 09-29-2011 |
20110257095 | PHARMACEUTICAL COMPOSITIONS AND RELATED METHODS OF DELIVERY - The pharmaceutical compositions described herein include a suspension which comprises an admixture in solid form of a therapeutically effective amount of a therapeutic agent and at least one salt of a medium chain fatty acid and a hydrophobic medium, e.g. castor oil or glyceryl tricaprylate or a mixture thereof. The pharmaceutical compositions described herein contain medium chain fatty acid salts and are substantially free of alcohols. The pharmaceutical compositions may be encapsulated in a capsule. Methods of treating or preventing diseases by administering such compositions to affected subjects are also disclosed. | 10-20-2011 |
20120148547 | COMBINATION OF VITAMIN E AND BETA-GLYCOSPHINGOLIPIDS IN COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING HEPATIC DISORDERS - The present invention relates to combined compositions comprising a combination of at least one natural or synthetic beta-glycolipid and at least one tocopherol (vitamin E). The invention further provides methods and kits using said combined compositions for treating and preventing hepatic disorders, specifically, liver insult cause by hepatotoxic drugs or caused by any one of infectious, metabolic, toxic, immune, or perfusion or blood flow related hepatic injury. | 06-14-2012 |
20120245380 | Inhibition of Ornithine Aminotransferase for the Treatment of Proliferative Disorders - The invention relates to inhibition of ornithine aminotransferase (OAT) for suppression of tumor cells proliferation. More particularly, the invention relates to methods of treatment of proliferative disorders by the selective inhibition of OAT, and further provides the use of OAT inhibitors, specifically, 5-amino-1,3-hexadienyl-carboxylic acid (Gabaculine), and Gabaculine analogue 8, for compositions and methods for the treatment of proliferative disorders such as hepatocellular carcinoma. The invention further provides methods and kits for the diagnosis of a pathologic proliferative disorder in a mammalian subject, based on determining the level of OAT expressed in a biological sample obtained from a subject. | 09-27-2012 |
20120264781 | METHOD FOR THE TREATMENT, ALLEVIATION OF SYMPTOMS OF, RELIEVING, IMPROVING AND PREVENTING A COGNITIVE DISEASE, DISORDER OR CONDITION - The present invention provides uses of a salt adduct comprising at least one positively charged moiety being a pyridoxine or a derivative thereof and at least one carboxylated 5- to 7-membered lactam ring, optionally additionally substituted, for the preparation of a medicament for the treatment, alleviation of symptoms of relieving, improving and preventing a cognitive disease, disorder or condition in a subject. Additionally, the invention provides use of said salt adducts for the preparation of medicaments for the improvement of cognitive functions in a healthy subject. | 10-18-2012 |
20120277270 | Method for Decreasing Symptoms of Alcohol Consumption - The present invention relates to methods and compositions of metadoxine and physiologically compatible active derivatives thereof, and their use for decreasing symptoms of alcohol consumption as well as in the prevention of alcohol consumption related symptoms in subjects in need thereof. | 11-01-2012 |
20130012549 | Method for the Treatment, Alleviation of Symptoms of, Relieving, Improving and Preventing a Cognitive Disease, Disorder or Condition - The present invention provides uses of a salt adduct comprising at least one positively charged moiety being a pyridoxine or a derivative thereof and at least one carboxylated 5- to 7-membered lactam ring, optionally additionally substituted, for the preparation of a medicament for the treatment, alleviation of symptoms of, relieving, improving and preventing a cognitive disease, disorder or condition in a subject. Additionally, the invention provides use of said salt adducts for the preparation of medicaments for the improvement of cognitive functions in a healthy subject. | 01-10-2013 |
20130078238 | Methods and Compositions for Treating Hepatitis with Anti-CD3 Immune Molecule Therapy - A method or composition comprising an anti-CD3 immune molecule for treatment of hepatitis in a subject. | 03-28-2013 |
20130164302 | Immuno-Modulating Compositions for the Treatment of Immune-Mediated Disorders - The present invention relates to immunomodulatory compositions comprising mammalian colostrum-derived immunoglobulin preparation and optionally further colostrums, milk or milk product component/s and any adjuvants for treating immune-related disorders. More specifically, the invention provides compositions comprising colostrum-derived anti-insulin immunoglobulin preparations for the treatment of Metabolic Syndrome. The invention further provides methods and uses of the immunomodulatory compositions for an active or passive immunization in a disease-antigen specific or non specific manner. | 06-27-2013 |
20130202724 | SOYBEAN EXTRACTS FOR THE TREATMENT OF HEPATIC DISORDERS - The invention provides methods and uses of different soybean extracts, for example, enzymatic, hexane, ethanol or aqueous soybean extracts and combinations thereof for the treatment of hepatic disorders, drug induced hepatic injury, the Metabolic Syndrome or an immune-related disorder in a subject in need thereof. The invention further provides pharmaceutical compositions, kits and methods thereof for treating and preventing hepatic disorders. | 08-08-2013 |
20130224216 | ANTI-LPS ENRICHED IMMUNOGLOBULIN FOR USE IN TREATMENT AND/OR PROPHYLAXIS OF A PATHOLOGIC DISORDER - Methods and compositions for treating conditions including liver dysfunction, e.g., associated with fatty liver; glucose intolerance; and others, by administering compositions comprising anti-LPS immunoglobulin enriched colostrum preparations. | 08-29-2013 |
20140024953 | BREATH TEST DEVICE AND METHOD - There is provided a method of evaluating a liver condition of a subject, the method includes computing a fluctuation parameter from a liver breath test based on at least one of a percentage dose recovery (PDR) curve and a delta over baseline (DOB) curve of an isotope labeled methacetin, or a salt or a derivative thereof, and evaluating at least one liver condition of the subject, based at least on the fluctuation parameter. There is provided herein a method of evaluating a liver condition of a subject, the method includes computing a hepatic impairment score based at least on a breath test related parameter and on a demographic parameter. | 01-23-2014 |
20140033795 | Methods For Diagnosis, Prognosis, Monitoring And Treatment Of Hepatocellular Carcinoma - The present invention relates to methods and systems for diagnosis, prognosis and monitoring of hepatocellular carcinoma (HCC). Specifically, the present invention relates to the use of breath tests based on isotope-labeled octanoate in the detection and monitoring of HCC. | 02-06-2014 |
20140255403 | ORAL COMPOSITION COMPRISING A TNF ANTAGONIST AND USE THEREOF - This application describes a method of delivering a TNF antagonist molecule, in a biologically active form, to a subject in need thereof, the method comprising, orally or mucosally administering to the subject a therapeutically effective amount of a TNF antagonist molecule. | 09-11-2014 |
20140255420 | Combination Therapy of Beta-Glycolipids and Antibodies for the Treatment of Immune-Related Disorders - The present invention relates to a combination therapy for the treatment of immune-related disorders. More particularly, the invention relates to oral or mucosal synergistic compositions combining beta-glycolipids, preferably, β-glycosphin-golipids with immunoglobulin molecules specific for at least one antigen derived from a component of the immune system, specifically an anti-CD3 antibody. The invention further provides methods kits and uses of the combined compositions of the invention for immune-modulation and thereby for the treatment of immune-related disorders. In a preferred embodiment, anti-CD3 antibody (OKT3) is orally administered in combination with β-glucosylceramide (also known as glycocerebroside) in an animal model of type 2 diabetes. | 09-11-2014 |
20140341952 | METHOD OF TREATMENT OF DISEASES USING HOODIA EXTRACTS - A method for treating a disease comprising administering to a mammal in need thereof an effective dosage of an extract of a plant of the genus | 11-20-2014 |
20150080348 | Compositions And Methods For Amelioration And Prevention Of Drug-Induced Toxicity - Pharmaceutical compositions including combinations of protective agents selected from isosilybin B, methylsulfonylmethane (MSM), phosphatidylcholine, cysteine (Cys), seleno-cysteine (Se-Cys), ribose-cysteine (RibCys), N-acetylcysteine (NAC), N-acetylcysteine-amide (AD4), methionine (Met) and S-adenosylmethionine (SAM) for reducing and/or preventing drug-induced toxicity, such as acetaminophen-induced toxicity. The compositions may be formulated with or without acetaminophen, and accordingly may be used as safe formulations of acetaminophen with reduced risk of causing liver damage, or as an antidote for the treatment of acetaminophen overdose. Methods for treating acetaminophen intoxication. | 03-19-2015 |