Patent application number | Description | Published |
20090326961 | EFFICIENT AND SECURE FORENSIC MARKING IN COMPRESSED DOMAIN - Methods, devices, and computer program products enable the embedding of forensic marks in a host content that is in compressed domain. These and other features are achieved by preprocessing of a host content to provide a plurality of host content versions with different embedded watermarks that are subsequently compressed. A host content may then be efficiently marked with forensic marks in response to a request for such content. The marking process is conducted in compressed domain, thus reducing the computational burden of decompressing and re-compressing the content, and avoiding further perceptual degradation of the host content. In addition, methods, devices and computer program products are disclosed that obstruct differential analysis of such forensically marked content. | 12-31-2009 |
20110294501 | CODEC DEPLOYMENT USING IN-BAND SIGNALS - After a call is established between two stations using a codec that has been negotiated during call setup, in-band signaling may be used between the two stations to change the codec that is to be used. The in-band signals are indicative that the station that is transmitting the in-band signals can operate with a second codec and are used to probe whether the receiving station can also operate with that second codec. If the receiving station detects and reacts to the in-band signals, then both stations change to communicate with the second codec. The second codec has compatible packet sizes of the deployed (originally negotiated) codec without any need of infrastructure upgrade and/or quality compromise to legacy phone users (i.e., stations that cannot operate with the second codec). | 12-01-2011 |
20110295598 | SYSTEMS, METHODS, APPARATUS, AND COMPUTER PROGRAM PRODUCTS FOR WIDEBAND SPEECH CODING - Methods of audio coding are described in which an excitation signal for a first frequency band of the audio signal is used to calculate an excitation signal for a second frequency band of the audio signal that is separated from the first frequency band. | 12-01-2011 |
20120300977 | EFFICIENT AND SECURE FORENSIC MARKING IN COMPRESSED DOMAIN - Methods, devices, and computer program products enable the embedding of forensic marks in a host content that is in compressed domain. These and other features are achieved by preprocessing of a host content to provide a plurality of host content versions with different embedded watermarks that are subsequently compressed. A host content may then be efficiently marked with forensic marks in response to a request for such content. The marking process is conducted in compressed domain, thus reducing the computational burden of decompressing and re-compressing the content, and avoiding further perceptual degradation of the host content. In addition, methods, devices and computer program products are disclosed that obstruct differential analysis of such forensically marked content. | 11-29-2012 |
20130108101 | EFFICIENT AND SECURE FORENSIC MARKING IN COMPRESSED DOMAIN | 05-02-2013 |
Patent application number | Description | Published |
20110115000 | Semiconductor Device having Strain Material - A semiconductor device having strain material is disclosed. In a particular embodiment, the semiconductor device includes a first cell including a first gate between a first drain and a first source. The semiconductor device also includes a second cell adjacent to the first cell. The second cell includes a second gate between a second drain and a second source. The semiconductor device further includes a shallow trench isolation area between the first source and the second source. A first amount of strain material over the first source and over the second source is greater than a second amount of strain material over the first drain and over the second drain. | 05-19-2011 |
20110140288 | Systems and Methods Employing a Physically Asymmetric Semiconductor Device Having Symmetrical Electrical Behavior - An integrated circuit device comprising a first elongate structure and a second elongate structure arranged parallel to each other and defining a space therebetween. The integrated circuit device also includes conductive structures distributed in the space between the first and second elongate structures. At least a first one of the conductive structures is placed closer to the first elongate structure than to the second elongate structure. At least a second one of the conductive structures is placed closer to the second elongate structure than to the first elongate structure. | 06-16-2011 |
20110188328 | Systems and Methods for Writing to Multiple Port Memory Circuits - A multiple-port RAM circuit has a data-in line coupled to multiple bit lines and multiple bit line bars. The circuit also has multiple word lines. A memory cell is coupled to the bit lines, bit line bars, and word lines. The circuit further includes a controller than enables the word lines to substantially simultaneously write a value from the bit lines to the memory cell. | 08-04-2011 |
20130099851 | SEMICONDUCTOR DEVICE HAVING STRAIN MATERIAL - A semiconductor device having strain material is disclosed in a particular embodiment, the semiconductor device includes a first cell including a first gate between a first drain and a first source. The semiconductor device also includes a second cell adjacent to the first cell. The second cell includes a second gate between a second drain and a second source. The semiconductor device further includes a shallow trench isolation area between the first source and the second source. A first amount of strain material over the first source and over the second source is greater than a second amount of strain material over the first drain and over the second drain. | 04-25-2013 |
20140264751 | METAL-INSULATOR-METAL (MIM) CAPACITOR - In one embodiment, a chip comprises a capacitor and a resistor. The capacitor comprises a first capacitor terminal, a second capacitor terminal, and a dielectric layer between the first and second capacitor terminals. The second capacitor terminal and the resistor are both fabricated from a resistor metal layer. | 09-18-2014 |
Patent application number | Description | Published |
20110175170 | STRUCTURE AND METHOD FOR MAKING LOW LEAKAGE AND LOW MISMATCH NMOSFET - An improved SRAM and fabrication method are disclosed. The method comprises use of a nitride layer to encapsulate PFETs and logic NFETs, protecting the gates of those devices from oxygen exposure. NFETs that are used in the SRAM cells are exposed to oxygen during the anneal process, which alters the effective work function of the gate metal, such that the threshold voltage is increased, without the need for increasing the dopant concentration, which can adversely affect issues such as mismatch due to random dopant fluctuation, GIDL and junction leakage. | 07-21-2011 |
20130193523 | STRUCTURE AND METHOD FOR MAKING LOW LEAKAGE AND LOW MISMATCH NMOSFET - An improved SRAM and fabrication method are disclosed. The method comprises use of a nitride layer to encapsulate PFETs and logic NFETs, protecting the gates of those devices from oxygen exposure. NFETs that are used in the SRAM cells are exposed to oxygen during the anneal process, which alters the effective work function of the gate metal, such that the threshold voltage is increased, without the need for increasing the dopant concentration, which can adversely affect issues such as mismatch due to random dopant fluctuation , GIDL and junction leakage. | 08-01-2013 |
20130228900 | Gate conductor with a diffusion barrier - A gate conductor structure is provided having a barrier region between a N-type device and a P-type device, wherein the barrier region minimizes or eliminates cross-diffusion of dopant species across the barrier region. The barrier region comprises at least one sublithographic gap in the gate conductor structure. The sublithographic gap is formed by using self-assembling copolymers to form a sublithographic patterned mask over the gate conductor structure. According to one embodiment, at least one sublithographic gap is a slit or line that traverses the width of the gate conductor structure. The sublithographic gap is sufficiently deep to minimize or prevent cross-diffusion of the implanted dopant from the upper portion of the gate conductor. According to another embodiment, the sublithographic gaps are of sufficient density that cross-diffusion of dopants is reduced or eliminated during an activation anneal such that changes in Vt are minimized. | 09-05-2013 |
20130277796 | ELECTRICAL FUSE AND METHOD OF MAKING - A semiconductor fuse and methods of making the same. The fuse includes a fuse element and a compressive stress liner that reduces the electro-migration resistance of the fuse element. The method includes forming a substrate, forming a trench feature in the substrate, depositing fuse material in the trench feature, depositing compressive stress liner material over the fuse material, and patterning the compressive stress liner material. | 10-24-2013 |
20140027851 | BODY CONTACTS FOR FET IN SOI SRAM ARRAY - Contact with a floating body of an FET in SOI may be formed in a portion of one of the two diffusions of the FET, wherein the portion of the diffusion (such as N−, for an NFET) which is “sacrificed” for making the contact is a portion of the diffusion which is not immediately adjacent (or under) the gate. This works well with linked body FETs, wherein the diffusion does not extend all the way to BOX, hence the linked body (such as P−) extends under the diffusion where the contact is being made. An example showing making contact for ground to two NFETs (PG and PD) of a 6T SRAM cell is shown. | 01-30-2014 |
20150037957 | SEMICONDUCTOR DEVICES HAVING TENSILE AND/OR COMPRESSIVE STRESS AND METHODS OF MANUFACTURING - Semiconductor devices are provided which have a tensile and/or compressive strain applied thereto and methods of manufacturing. A method of forming a semiconductor structure includes forming sidewalls and spacers adjacent to a gate stack structure, and forming a recess in the gate stack structure. The method further includes epitaxially growing a straining material on a polysilicon layer of the gate stack structure, and in the recess in the gate stack structure. The straining material is Si:C and the gate stack structure is a PFET gate stack structure. The straining material is grown above and covering a top surface of the sidewalls and the spacers. | 02-05-2015 |
20150054028 | SEMICONDUCTOR DEVICES HAVING TENSILE AND/OR COMPRESSIVE STRESS AND METHODS OF MANUFACTURING - Semiconductor devices are provided which have a tensile and/or compressive strain applied thereto and methods of manufacturing. The structure includes a gate stack comprising an oxide layer, a polysilicon layer and sidewalls with adjacent spacers. The structure further includes an epitaxially grown straining material directly on the polysilicon layer and between portions of the sidewalls. The epitaxially grown straining material, in a relaxed state, strains the polysilicon layer. | 02-26-2015 |
Patent application number | Description | Published |
20120273716 | LITHIUM-ION BATTERY MATERIALS WITH IMPROVED PROPERTIES - A cobalt-containing phosphate material can comprise lithium (Li) (or, alternatively or additionally other alkali metal(s)), cobalt (Co), phosphate (PO | 11-01-2012 |
20120315534 | Materials for Battery Electrolytes and Methods for Use - Described herein are materials for use in electrolytes that provide a number of desirable characteristics when implemented within batteries, such as high stability during battery cycling up to high temperatures high voltages, high discharge capacity, high coulombic efficiency, and excellent retention of discharge capacity and coulombic efficiency over several cycles of charging and discharging. In some embodiments, a high voltage electrolyte includes a base electrolyte and a set of additive compounds, which impart these desirable performance characteristics. | 12-13-2012 |
20120315536 | Materials for Battery Electrolytes and Methods for Use - Described herein are materials for use in electrolytes that provide a number of desirable characteristics when implemented within batteries, such as high stability during battery cycling up to high temperatures high voltages, high discharge capacity, high coulombic efficiency, and excellent retention of discharge capacity and coulombic efficiency over several cycles of charging and discharging. In some embodiments, a high voltage electrolyte includes a base electrolyte and a set of additive compounds, which impart these desirable performance characteristics. | 12-13-2012 |
20120315551 | Materials for Battery Electrolytes and Methods for Use - Described herein are materials for use in electrolytes that provide a number of desirable characteristics when implemented within batteries, such as high stability during battery cycling up to high temperatures high voltages, high discharge capacity, high coulombic efficiency, and excellent retention of discharge capacity and coulombic efficiency over several cycles of charging and discharging. In some embodiments, a high voltage electrolyte includes a base electrolyte and a set of additive compounds, which impart these desirable performance characteristics. | 12-13-2012 |
20120328939 | Materials for Battery Electrolytes and Methods for Use - Described herein are materials for use in electrolytes that provide a number of desirable characteristics when implemented within batteries, such as high stability during battery cycling up to high temperatures high voltages, high discharge capacity, high coulombic efficiency, and excellent retention of discharge capacity and coulombic efficiency over several cycles of charging and discharging. In some embodiments, a high voltage electrolyte includes a base electrolyte and a set of additive compounds, which impart these desirable performance characteristics. | 12-27-2012 |
20130029217 | Materials for Battery Electrolytes and Methods for Use - Described herein are materials for use in electrolytes that provide a number of desirable characteristics when implemented within batteries, such as high stability during battery cycling up to high temperatures high voltages, high discharge capacity, high coulombic efficiency, and excellent retention of discharge capacity and coulombic efficiency over several cycles of charging and discharging. In some embodiments, a high voltage electrolyte includes a base electrolyte and a set of additive compounds, which impart these desirable performance characteristics. | 01-31-2013 |
20130059200 | Materials for Battery Electrolytes and Methods for Use - Described herein are materials for use in electrolytes that provide a number of desirable characteristics when implemented within batteries, such as high stability during battery cycling up to high temperatures high voltages, high discharge capacity, high coulombic efficiency, and excellent retention of discharge capacity and coulombic efficiency over several cycles of charging and discharging. In some embodiments, a high voltage electrolyte includes a base electrolyte and a set of additive compounds, which impart these desirable performance characteristics. | 03-07-2013 |
20140113186 | Materials for Battery Electrolytes and Methods for Use - Described herein are materials for use in electrolytes that provide a number of desirable characteristics when implemented within batteries, such as high stability during battery cycling up to high temperatures high voltages, high discharge capacity, high coulombic efficiency, and excellent retention of discharge capacity and coulombic efficiency over several cycles of charging and discharging. In some embodiments, a high voltage electrolyte includes a base electrolyte and a set of additive compounds, which impart these desirable performance characteristics. | 04-24-2014 |
20140120414 | Materials for Battery Electrolytes and Methods for Use - Described herein are materials for use in electrolytes that provide a number of desirable characteristics when implemented within batteries, such as high stability during battery cycling up to high temperatures high voltages, high discharge capacity, high coulombic efficiency, and excellent retention of discharge capacity and coulombic efficiency over several cycles of charging and discharging. In some embodiments, a high voltage electrolyte includes a base electrolyte and a set of additive compounds, which impart these desirable performance characteristics. | 05-01-2014 |
20140152269 | Materials for Battery Electrolytes and Methods for Use - Described herein are materials for use in electrolytes that provide a number of desirable characteristics when implemented within batteries, such as high stability during battery cycling up to high temperatures high voltages, high discharge capacity, high coulombic efficiency, and excellent retention of discharge capacity and coulombic efficiency over several cycles of charging and discharging. In some embodiments, a high voltage electrolyte includes a base electrolyte and a set of additive compounds, which impart these desirable performance characteristics. | 06-05-2014 |
20140295219 | Materials for Battery Electrolytes and Methods for Use - Described herein are materials for use in electrolytes that provide a number of desirable characteristics when implemented within batteries, such as high stability during battery cycling up to high temperatures high voltages, high discharge capacity, high coulombic efficiency, and excellent retention of discharge capacity and coulombic efficiency over several cycles of charging and discharging. In some embodiments, a high voltage electrolyte includes a base electrolyte and a set of additive compounds, which impart these desirable performance characteristics. | 10-02-2014 |
20140302388 | Materials Prepared by Metal Extraction - A method for extracting ions from an active material for use in a battery electrode includes mixing the active material and an activating compound to form a mixture. The mixture is annealed such that an amount of ions is extracted from the active material, an amount of oxygen is liberated from the active material, and an activated active material is formed. Embodiments of the invention include the activated active material, the electrode, and the primary and secondary batteries formed from such activated active materials. | 10-09-2014 |
Patent application number | Description | Published |
20090249500 | SYSTEM FOR MONITORING BACTERIAL TUMOR TREATMENT - A method to follow the progress of tumor treatment in subjects utilizes bacteria that have been modified to express a fluorescent protein. The method can also monitor expression of genes associated with the bacteria that produce therapeutic agents during the course of treatment, optionally against a background of fluorescence generated by the tumor itself. The method permits visualization of the progress of treatment in live subjects so that treatments can be modified according to their efficacy. | 10-01-2009 |
20090300779 | Cancer selective auxotrophs - Bacteria that are auxotrophic for at least two amino acids found in at least one tumor are effective anti tumor treatments, labeling agents, and vaccines against infection. Improved antitumor effects can also be provided such strains by passage through an appropriate tumor model. | 12-03-2009 |
20100068148 | ENHANCED RESOLUTION OF TUMOR METASTASIS USING A SKIN FLAP MODEL - A enhanced method for observing tumor progression, angiogenesis and/or metastasis in animal models in real time is described. The invention employs a skin flap over the area to be observed that can be opened and closed reversibly. The invention also permits simultaneous observation of more than one tumor by use of multiple colors. | 03-18-2010 |
20100159589 | NESTIN-EXPRESSING HAIR FOLLICLE STEM CELLS - Hair follicle stem cells are isolated by virtue of understanding their location within the hair follicle during telogen phase. | 06-24-2010 |
20110033388 | IMAGEABLE RODENT MODEL OF ASTHMA - An imageable rodent model for asthma is described. The invention provides a rodent model for asthma wherein a rodent is provided with fluorescently labeled lymphocytes sensitized to an allergen which can be monitored after inducing an asthmatic response by the allergen. Methods to monitor trafficking of the fluorescently labeled cells in the rodent model for asthma are provided. Methods to determine the effectiveness of candidate drugs that regulate asthmatic responses using the rodent asthma model are also provided. | 02-10-2011 |
Patent application number | Description | Published |
20100246944 | Using a video processing and text extraction method to identify video segments of interest - A video processing technique is performed on a video media service to identify video segments of interest. The video processing technique ( | 09-30-2010 |
20120019684 | Method for controlling and requesting information from displaying multimedia - The invention provides a robust method to control interactive media using gestures. A method to retrieve metadata information from a multimedia outlet device, wherein the method follows the steps: (1) extracting image hot spot areas in a current captured image using face detection, (2) detecting a human gesture directive in at least one image hot spot area using gesture recognition, (3) determining if the gesture directive matches a pre-assigned command to a rich interaction module, (4) sending a signal to a rich interaction module corresponding to the pre-assigned command detected, (5) extracting a media image hot spot area from electrical signals sent from the multimedia, (6) matching any detected human gestures in at least one image hot spot area using gesture recognition with a specific pixel on a device screen, and (7) retrieving information from metadata assigned to an area of pixels on the screen. | 01-26-2012 |
20120232988 | METHOD AND SYSTEM FOR GENERATING DYNAMIC ADS WITHIN A VIDEO GAME OF A PORTABLE COMPUTING DEVICE - A method and system for generating and tracking dynamic advertisements within a program, such as a video game, running on a portable computing device (PCD) are described. The method and system include receiving a call from the program for a texture and reviewing an identifier associated with the texture. A graphics driver determines if the identifier associated with the texture matches an identifier in a texture database. The graphics driver then selects a dynamic advertisement from a texture database if the identifier associated with the texture matches the identifier in the texture database. The graphics driver issues commands to the graphics processor so that dynamic advertisement is presented on a screen display. The graphics driver then determines if a video object produced by the program blocks a portion of the dynamic advertisement present on the screen display. | 09-13-2012 |
20130194392 | Mobile Device Configured to Compute 3D Models Based on Motion Sensor Data - A particular method includes determining, based on data received from at least one motion sensor, a movement of a mobile device from a first position to a second position. The method also includes computing a three-dimensional (3D) model of an object based on a first image of the object corresponding to a first view of the object from the first position of the mobile device, a second image of the object corresponding to a second view of the object from the second position of the mobile device, and the movement of the mobile device. | 08-01-2013 |
20130278734 | METHOD AND SYSTEM FOR GENERATING DYNAMIC ADS WITHIN A VIDEO GAME OF A PORTABLE COMPUTING DEVICE - A method and system for generating and tracking dynamic advertisements within a program, such as a video game, running on a portable computing device (PCD) are described. The method and system include receiving a call from the program for a texture and reviewing an identifier associated with the texture. A graphics driver determines if the identifier associated with the texture matches an identifier in a texture database. The graphics driver then selects a dynamic advertisement from a texture database if the identifier associated with the texture matches the identifier in the texture database. The graphics driver issues commands to the graphics processor so that dynamic advertisement is presented on a screen display. The graphics driver then determines if a video object produced by the program blocks a portion of the dynamic advertisement present on the screen display. | 10-24-2013 |
20140071241 | Devices and Methods for Augmented Reality Applications - In a particular embodiment, a method includes evaluating, at a mobile device, a first area of pixels to generate a first result. The method further includes evaluating, at the mobile device, a second area of pixels to generate a second result. Based on comparing a threshold with a difference between the first result and the second result, a determination is made that the second area of pixels corresponds to a background portion of a scene or a foreground portion of the scene. | 03-13-2014 |
Patent application number | Description | Published |
20120280868 | MOBILE WIRELESS COMMUNICATIONS DEVICE HAVING ANTENNA ASSEMBLY WITH ELECTRICALLY CONDUCTIVE BASE ENCLOSING AN ELONGATE SLOT AND ASSOCIATED METHODS - A mobile wireless communications device may include a housing carrying a circuit board and wireless communications circuitry. An antenna assembly is carried by the housing and coupled to the wireless communications circuitry. The antenna assembly may include an electrically conductive base having a rectangular shape with opposing first and second ends and opposing first and second sides extending between the first and second ends. The electrically conductive base may have an elongate slot therein extending within a medial portion thereof and contained within the opposing first and second ends and the opposing first and second sides. The antenna assembly also may include an electrically conductive feed arm extending outwardly from the first side of the electrically conductive base adjacent the first end thereof. The electrically conductive feed arm may have a distal end with an antenna feed defined thereon. | 11-08-2012 |
20140168030 | Reconfigurable Multiband Antenna - A mobile node (MN) comprising an antenna comprising a proximate end, a distal end, and a midpoint, a first feed coupled to the antenna between the proximate end and the midpoint, a second feed coupled to the antenna between the distal end and the midpoint, a first switch configured to toggle between coupling the first feed to a main feed and coupling the second feed to the main feed, and a controller configured to control the toggling of the first switch. | 06-19-2014 |
20140187178 | Method and Apparatus for a Tunable Antenna - A method for tuning an antenna comprising determining an operating frequency band of the antenna, and adjusting a capacitance of a tunable load according to the operating frequency band, wherein the tunable load is electromagnetically coupled to the antenna via a parasitic arm, and wherein the operating frequency band depends on the capacitance. | 07-03-2014 |
20140253399 | Wideband Slot Antenna for Wireless Communication Devices - An antenna comprising a conductive base comprising a west edge, an east edge, a north edge, a south edge, and a center axis, a left slot of nonconductive material extending from the south edge toward the north edge and positioned between the west edge and the center axis, and a right slot of nonconductive material extending from the south edge toward the north edge and positioned between the east edge and the center axis. | 09-11-2014 |
Patent application number | Description | Published |
20140042873 | Apparatus and Method for Charging a Mobile Device - An apparatus, a method, and a computer program product are provided. The apparatus may be a mobile device. The mobile device receives a first mechanical force applied to at least one region on the mobile device, performs a function unrelated to energy conversion in response to the first mechanical force, receives a second mechanical force applied to the at least one region on the mobile device, converts the second mechanical force into electrical energy using at least one piezoelectric element, and powers at least one component of the mobile device using the electrical energy. | 02-13-2014 |
20140274222 | Hands-Off Detection and Deactivation for Handheld User Devices - A user device having an active application periodically detects for a hands-off state of the user device. Upon detecting a hands-off state, the user device affects at least one of the active application and the user device. Prior to affecting at least one of the active application and the user device, the user device detects for one or more of a connection between the user device and another device, and an application of pressure to the user device. If either is detected the, the user device bypasses affecting at least one of the active application and the user device. | 09-18-2014 |
20140278437 | USER SENSING SYSTEM AND METHOD FOR LOW POWER VOICE COMMAND ACTIVATION IN WIRELESS COMMUNICATION SYSTEMS - A method of activating voice control on a wireless device includes sampling signals from a plurality of sensors on the device, determining if the device is in a hands-on state by a user on the basis of the signal sampling, and enabling a voice activated detection (VAD) application on the device on the basis of the determination. A voice controlled apparatus in a wireless device includes a plurality of sensors arranged on the device, a microphone, a controller to sample signals from one or more of the plurality of sensors, a processor coupled to the controller, and a voice activated detection (VAD) application running on the processor coupled to the controller and the microphone. | 09-18-2014 |
Patent application number | Description | Published |
20080200349 | MICRODEVICES HAVING A PREFERENTIAL AXIS OF MAGNETIZATION AND USES THEREOF - This invention relates generally to the field of moiety or molecule isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided. | 08-21-2008 |
20100260984 | MICRODEVICES CONTAINING PHOTORECOGNIZABLE CODING PATTERNS AND METHODS OF USING AND PRODUCING THE SAME - This invention relates generally to the field of moiety or molecule analysis, isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a substrate; and b) a photorecognizable coding pattern on said substrate. Preferably, the microdevice does not comprise an anodized metal surface layer. Methods and kits for isolating, detecting and manipulating moieties, and synthesizing libraries using the microdevices are also provided. The invention further provides two-dimensional optical encoders and uses thereof. In certain embodiments, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided. | 10-14-2010 |
20120228386 | MICRODEVICES CONTAINING PHOTORECOGNIZABLE CODING PATTERNS AND METHODS OF USING AND PRODUCING THE SAME - This invention relates generally to the field of moiety or molecule analysis, isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a substrate; and b) a photorecognizable coding pattern on said substrate. Preferably, the microdevice does not comprise an anodized metal surface layer. Methods and kits for isolating, detecting and manipulating moieties, and synthesizing libraries using the microdevices are also provided. The invention further provides two-dimensional optical encoders and uses thereof. In certain embodiments, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided. | 09-13-2012 |
Patent application number | Description | Published |
20090110672 | Angiogenic Tyrosyl tRNA Synthetase Compositions and Methods - The present invention provides an isolated tyrosyl tRNA synthetase (TyrRS) polypeptide variant which comprises (a) a Rossmann fold region or a portion thereof, preferably including an 5 coil; and (b) an anticodon recognition domain or portion thereof, preferably including an 14 coil. Preferably, the 5 coil and the 14 coil have a greater spatial separation in the tertiary structure of the variant compared to the corresponding spatial separation in native human TyrRS. The variant preferably comprises an amino acid residue sequence identity of at least about 50% compared to the amino acid residue sequence of human TyrRS (SEQ ID NO: 3), includes at least one non-conservative amino acid residue sequence of human TyrRS, and preferably presents an exposed ELR motif in the 5 coil on an external portion of the tertiary structure of the polypeptide. A preferred TyrRS protein variant comprises the amino acid residue sequence of SEQ ID NO: 4 or a portion thereof. The proteins and protein fragments of the invention are angiogenic and are useful for stimulating angiogenesis in mammalian tissues. | 04-30-2009 |
20120014938 | Angiogenic Tyrosyl t-RNA Synthetase Compositions and Methods - The present invention provides an isolated tyrosyl tRNA synthetase (TyrRS) polypeptide variant which comprises (a) a Rossmann fold region or a portion thereof, preferably including an α5 coil; and (b) an anticodon recognition domain or portion thereof, preferably including an α14 coil. Preferably, the α5 coil and the α14 coil have a greater spatial separation in the tertiary structure of the variant compared to the corresponding spatial separation in native human TyrRS. The variant preferably comprises an amino acid residue sequence identity of at least about 50% compared to the amino acid residue sequence of human TyrRS (SEQ ID NO: 3), includes at least one non-conservative amino acid residue substitution relative to the amino acid residue sequence of human TyrRS, and preferably presents an exposed ELR motif in the α5 coil on an external portion of the tertiary structure of the polypeptide. A preferred TyrRS protein variant comprises the amino acid residue sequence of SEQ ID NO: 4 or a portion thereof. The proteins and protein fragments of the invention are angiogenic and are useful for stimulating angiogenesis in mammalian tissues. | 01-19-2012 |
20140066321 | STRUCTURES OF HUMAN HISTIDYL-TRNA SYNTHETASE AND METHODS OF USE - Provided are histidyl-tRNA synthetase variant polypeptides, X-ray crystallographic and NMR spectroscopy structures of HRS polypeptides, and related compositions and methods for therapy and drug discovery. | 03-06-2014 |
Patent application number | Description | Published |
20100113508 | Modulators of Cystic Fibrosis Transmembrane Conductance Regulator - The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR. | 05-06-2010 |
20100331344 | Modulators of ATP-Binding Cassette Transporters - Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention. | 12-30-2010 |
20110071206 | Modulators of ATP-Binding Cassette Transporters - Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention. | 03-24-2011 |
20110257223 | Modulators of Cystic Fibrosis Transmembrane Conductance Regulator - The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to pharmaceutical compositions comprising a compound of Formula I with one or both of a Compound of Formula II and/or a Compound of Formula III. Further, the present invention relates to methods of treating CFTR mediated diseases, particularly cystic fibrosis, using modulators of CFTR, and compositions and combinations thereof. | 10-20-2011 |
20120071504 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR - This invention relates to a compound of Formula I: | 03-22-2012 |
20120208841 | Modulators of Cystic Fibrosis Transmembrane Conductance Regulator - The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR. | 08-16-2012 |
20130131107 | PHARMACEUTICAL COMPOSITIONS AND ADMINISTRATIONS THEREOF - The present invention relates to pharmaceutical compositions comprising a compound of Formulas I and II, optionally in combination with a Compound of Formula III and/or a Compound of Formula IV. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis. | 05-23-2013 |
20130158071 | PHARMACEUTICAL COMPOSITIONS AND ADMINISTRATIONS THEREOF - The present invention relates to pharmaceutical compositions comprising a compound of Formula I in combination with one or both of a Compound of Formula II and/or a Compound of Formula III. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis. | 06-20-2013 |
20130303570 | Modulators of Cystic Fibrosis Transmembrane Conductance Regulator - The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR. | 11-14-2013 |
20140057906 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS - Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention. | 02-27-2014 |
20140080826 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS - Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention. | 03-20-2014 |
20140088142 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR - This invention relates to a compound of Formula I: | 03-27-2014 |
20140303204 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR - The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR. | 10-09-2014 |
20140303205 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR - This invention relates to a compound of Formula I: | 10-09-2014 |
Patent application number | Description | Published |
20080210573 | MULTIPLEXED ELECTROCHEMICAL DETECTION SYSTEM AND METHOD - Multiplexed analysis of molecular structures of samples. A plurality of sample wells is arranged on a substrate. A plurality of electrodes is fabricated on a first side of the substrate. The electrodes are disposed on the side of the substrate exposed to the sample wells. The electrodes include working electrodes, counter electrodes, and optionally include reference electrodes. At least two of the sample wells includes a plurality of working electrodes. The plurality of electrodes is configured to allow electrochemical analysis of the associated sample wells in a multiplexed fashion. The plurality of electrodes is electrically coupled to an interface to a sample analysis system. The interface to the sample analysis system can include contacts or connections. The sample analysis system controls a signal to the electrodes in a multiplexed fashion and performs the electrochemical analysis. | 09-04-2008 |
20090042280 | FLUIDIC CARTRIDGES FOR ELECTROCHEMICAL DETECTION OF DNA - A flow cell cartridge for the detection of differences in nucleic acid sequences is disclosed. The flow cell cartridge has an electrode array and two openings, in which one opening is for the entry and exit of sample, and the other opening is for the control of the entry and exit of sample through the exertion of negative and positive pressure. The entire flow cell cartridge can be moved from sample to sample to allow different samples to be drawn into the cartridge into contact with an electrochemical electrode array, thus allowing reactions to occur in the chamber itself. | 02-12-2009 |
20100279299 | Devices and Methods for Heating Biological Samples - This invention provides a systems and methods for regulating temperature and heat transfer in applications in which it is desirable to maintain temperature uniformity such as thermal cycling applications. A heat block is used to rapidly transfer heat to or from a set of one or more reaction vessels. | 11-04-2010 |
20120276555 | Method of Using Non-Rare Cells to Detect Rare Cells - The invention provides seminal computational approaches utilizing data from non-rare cells to detect rare cells, such as circulating tumor cells (CTCs). The invention is applicable at two distinct stages of CTC detection; the first being to make decisions about data collection parameters and the second being to make decisions during data reduction and analysis. Additionally, the invention utilizes both one and multi-dimensional parameterized data in a decision making process. | 11-01-2012 |
20140308669 | METHODS FOR OBTAINING SINGLE CELLS AND APPLICATIONS OF SINGLE CELL OMICS - The present application provides methods for obtaining single cells from a sample. Methods for isolating and analyzing molecular features obtained from a single cell are also disclosed herein. For example, individual circulating tumor cells (CTCs) from a sample such as a patient's blood sample can be identified and obtained using methods disclosed herein, and picked for further analysis. | 10-16-2014 |
Patent application number | Description | Published |
20100016575 | BACTERIAL CELLULOSE-CONTAINING FORMULATIONS LACKING A CARBOXYMETHYL CELLULOSE COMPONENT - A method for the production of a bacterial cellulose-containing formulation that lacks a carboxymethyl cellulose component. The method includes providing a bacterial cellulose product, mixing the bacterial cellulose product with a polymeric thickener and/or a precipitation agent, lysing the bacterial cells from the bacterial cellulose product or the mixture of the bacterial cellulose product and the polymeric thickener or precipitation agent, and co-precipitating the resultant mixture with a water-miscible non-aqueous liquid. The resultant bacterial cellulose formulation includes at least one bacterial cellulose material and at least one polymeric thickener. The bacterial cellulose formulation, may be used in food compositions. | 01-21-2010 |
20110217442 | Compositions and Methods for Producing Consumables for Patients with Dysphagia - Compositions are provided that are suitable for safe consumption by a patient with dysphagia. In one embodiment, the compositions include a modified xanthan gum in an amount suitable to provide a viscous, free-flowing solution having gel-like properties. The modified xanthan gum comprises a non-pyruvylated xanthan gum, a reduced-pyruvylated xanthan gum, or a combination thereof. The composition desirably has a viscosity of greater than about 2000 cP and is characterized as having a shape retention of greater than about 50%. Also provided are methods for their preparation and use. | 09-08-2011 |
20110274629 | Natural Polymer Blends for Use in Personal Care Products - Embodiments of the present description provide a blend for use in a personal care product having a modified xanthan gum and a galactomannan, wherein the modified xanthan gum is a non-pyruvylated xanthan gum, and the modified xanthan gum and the galactomannan are present in the blend in a ratio from about 1:99 to about 99:1 by weight. Also provided in embodiments of the present description are personal care products having blends of modified xanthan gums and galactomannans, methods for product formulation, and use thereof. | 11-10-2011 |
20130059032 | Blends for Fermented Milk Products - A stabilizing additive for compositions, e.g., fermented milk products, is disclosed comprising xanthan gum and iota-carrageenan wherein the weight percentage of the xanthan gum in the stabilizing additive is higher than the weight percentage of the iota-carrageenan. The xanthan gum can be reduced pyruvate or non-pyruvylated xanthan. The stabilizing additive can further comprise a galactomannan. The composition can further comprise starch. Also disclosed is a method for making a fermented milk product comprising adding the stabilizing additive to milk and fermenting the milk or adding the stabilizing additive to already fermented milk. Fermented milk products comprising the additive can include, e.g., yogurt, drinkable yogurt, kefir or Ymer. | 03-07-2013 |
20140128480 | HIGHLY EFFICIENT AND CONVENIENT FORM OF MICROFIBROUS CELLULOSE - Microfibrous cellulose (MFC) broths are provided having improved performance as compared to wet cake microfibrous cellulose (MFC) and powdered microfibrous cellulose (MFC). In embodiments, compositions having an effective amount of an MFC broth and an effective amount of a surfactant have an improved yield value as compared to a composition having a surfactant and a wet cake MFC, a powdered MFC, or a combination thereof at the same concentration as the MFC broth. Also, methods are provided for improving the yield value of surfactant compositions by adding an effective amount of a microfibrous cellulose broth to an effective amount of surfactant to provide a surfactant composition having a yield value that is higher than a composition having the surfactant and a wet cake MFC, a powdered MFC, or a combination thereof at the same concentration as the microfibrous cellulose broth. | 05-08-2014 |
Patent application number | Description | Published |
20100260757 | USE OF PLP WITH PEG-rMETase IN VIVO FOR ENHANCED EFFICACY - This invention relates to methods of modifying pyridoxal 5′ phosphate (PLP) dependent enzymes to extend the serum half-life of the enzyme, extend the in vivo period of methionine depletion in a host, and decrease the immunogenicity of the enzyme. A preferred PLP-dependent enzyme to be modified is a methioninase, preferably a recombinant methioninase (rMETase). The invention further relates to compositions comprising a modified PLP-dependent enzyme and methods of using the same. | 10-14-2010 |
20100331529 | METHODS FOR INCREASING PROTEIN POLYETHYLENE GLYCOL (PEG) CONJUGATION - The present invention relates to highly conjugated proteins and methods for making such proteins. In particular, the present invention relates to methods for linking additional sites to a protein for conjugation with activated polyethylene glycol (PEG) linkers, without denaturing the protein. The invention also relates to highly conjugated proteins with decreased immunogenicity and increased circulating half-life. | 12-30-2010 |
20130252306 | METHODS FOR INCREASING PROTEIN POLYETHYLENE GLYCOL (PEG) CONJUGATION - The present invention relates to highly conjugated proteins and methods for making such proteins. In particular, the present invention relates to methods for linking additional sites to a protein for conjugation with activated polyethylene glycol (PEG) linkers, without denaturing the protein. The invention also relates to highly conjugated proteins with decreased immunogenicity and increased circulating half-life. | 09-26-2013 |
20140205583 | USE OF PLP WITH PEG-rMETase IN VIVO FOR ENHANCED EFFICACY - This invention relates to methods of modifying pyridoxal 5′ phosphate (PLP) dependent enzymes to extend the serum half-life of the enzyme, extend the in vivo period of methionine depletion in a host, and decrease the immunogenicity of the enzyme. A preferred PLP-dependent enzyme to be modified is a methioninase, preferably a recombinant methioninase (rMETase). The invention further relates to compositions comprising a modified PLP-dependent enzyme and methods of using the same. | 07-24-2014 |
Patent application number | Description | Published |
20120136073 | Amine-Containing Transfection Reagents and methods for making and using same - There are provided for herein novel amine-containing transfection compounds and methods for making and using same. The compounds are generally obtained by reacting a primary amine with an unsaturated compound. Transfection complexes made using the amine-containing transfection compounds in combination with additional compounds to encapsulate biologically active agents such as nucleic acids are also provided for herein. Methods of using the transfection complexes for the in vivo or in vitro delivery of biologically active agents are also described. The transfection complexes of the present invention are highly potent, thereby allowing effective modulation of a biological activity at relatively low doses compared to analogous transfection compounds known in the art. | 05-31-2012 |
20120220567 | BENZO-FUSED OXAZEPINE COMPOUNDS AS STEAROYL-COENZYME A DELTA-9 DESATURASE INHIBITORS - The present invention relates to certain 4,5-dihydro-3H-spiro[benzo[b]-[1,4]oxazepine compounds of the Formula (I) or a pharmaceutically acceptable salt thereof, wherein R | 08-30-2012 |
20120322066 | Development of Novel Detergents for Use in PCR Systems - This disclosure relates to novel detergents for use in various procedures including, for example, nucleic acid amplification reactions such as polymerase chain reaction (PCR). Methods for preparing the modified detergents are also described. | 12-20-2012 |
20140308666 | DEVELOPMENT OF NOVEL DETERGENTS FOR USE IN PCR SYSTEMS - This disclosure relates to novel detergents for use in various procedures including, for example, nucleic acid amplification reactions such as polymerase chain reaction (PCR). Methods for preparing the modified detergents are also described. | 10-16-2014 |
Patent application number | Description | Published |
20090175399 | DIGITAL PHASE-LOCKED LOOP WITH GATED TIME-TO-DIGITAL CONVERTER - A digital PLL (DPLL) includes a time-to-digital converter (TDC) and a control unit. The TDC is periodically enabled for a short duration to quantize phase information and disabled for the remaining time to reduce power consumption. The TDC receives a first clock signal and a first reference signal and provides a TDC output indicative of the phase difference between the first clock signal and the first reference signal. The control unit generates an enable signal based on a main reference signal and enables and disables the TDC with the enable signal. In one design, the control unit delays the main reference signal to obtain the first reference signal and a second reference signal, generates the enable signal based on the main reference signal and the second reference signal, and gates a main clock signal with the enable signal to obtain the first clock signal for the TDC. | 07-09-2009 |
20090219073 | HIGH RESOLUTION TIME-TO-DIGITAL CONVERTER - A time-to-digital converter (TDC) can have a resolution that is finer than the propagation delay of an inverter. In one example, a fractional-delay element circuit receives a TDC input signal and generates therefrom a second signal that is a time-shifted facsimile of a first signal. The first signal is supplied to a first delay line timestamp circuit (DLTC) and the second signal is supplied to a second DLTC. The first DLTC generates a first timestamp indicative of a time between an edge of a reference input signal to the TDC and an edge of the first signal. The second DLTC generates a second timestamp indicative of a time between the edge of the reference input signal and an edge of the second signal. The first and second timestamps are combined and together constitute a high-resolution overall TDC timestamp that has a finer resolution than either the first or second timestamps. | 09-03-2009 |
20090219187 | HIGH-SPEED TIME-TO-DIGITAL CONVERTER - Techniques for enabling a time-to-digital (TDC) to sample with sub-inverter delay resolution are disclosed. In an embodiment, the inputs to a differential D-Q flip-flop in the TDC are coupled to a single-ended signal and a delayed and inverted version of that signal to allow time interpolation of the signal. Further disclosed are techniques to balance the loads of a first delay line and a complementary delay line within the TDC. | 09-03-2009 |
20090262878 | SYSTEM AND METHOD OF CALIBRATING POWER-ON GATING WINDOW FOR A TIME-TO-DIGITAL CONVERTER (TDC) OF A DIGITAL PHASE LOCKED LOOP (DPLL) - A system and method are disclosed related to calibrating a power-on gating window for a time-to-digital converter (TDC) of a digital phase locked loop (DPLL). The gating window is calibrated to ensure proper operation of the DPLL, while at the same time operating the TDC in a power efficient manner. In particular, the technique entails setting the width of the TDC gating window to a default value; operating the DPLL until the control loop is substantially locked; decreasing the width of the TDC gating window by a predetermined amount, while monitoring the phase error signal generated by the phase error device of the DPLL; determining the current width of the TDC gating window at substantially a time when the phase error arrives at or crosses a predetermined threshold; and increasing the current width of the TDC gating window by a predetermined amount to build in a margin of error for the operating width of the TDC gating window. | 10-22-2009 |
20100102894 | DIGITALLY CONTROLLED OSCILLATOR WITH IMPROVED DIGITAL FREQUENCY CALIBRATION - Techniques for calibrating digitally controlled oscillators (DCOS) are disclosed. In one aspect of the disclosure, an initial set of control codes for operating the DCO with a coarse frequency tuning bank with multiple overlapping coarse frequency tuning segments (LTBs) and one fine main frequency tuning bank (MTB) is determined. A range of output frequencies produced from the initial set is identified. Instances of overlap are identified in the frequency range between consecutive LTB segments. An offset in the MTB is added that corresponds to the overlap instance between consecutive LTBs to establish a revised set. The revised control codes are utilized to tune the DCO over the desired frequency range. | 04-29-2010 |
20100182090 | ULTRA LOW NOISE HIGH LINEARITY LNA FOR MULTI-MODE TRANSCEIVER - An amplifier for operating at low, middle or high linearity modes, the amplifier comprising a first low noise amplifier (LNA) coupled to a second low noise amplifier for providing amplification; a first degeneration inductor coupled to the first LNA for providing impedance matching; a −g | 07-22-2010 |
20130135016 | DIVIDING A FREQUENCY BY 1.5 TO PRODUCE A QUADRATURE SIGNAL - An apparatus for dividing a frequency by 1.5 to produce a quadrature signal is disclosed. The apparatus includes a divider that receives a differential input signal with a first frequency and two phases and creates a six-phase signal at a second frequency. The second frequency is the first frequency divided by 3. The apparatus also includes precision phase rotation circuitry that receives the six-phase signal and produces an eight-phase signal. The apparatus also includes a doubler that receives the eight-phase signal and produces a quadrature signal. The quadrature signal has a third frequency that is the first frequency divided by 1.5. | 05-30-2013 |
20140273901 | REDUCING POWER CONSUMPTION ON A RECEIVER - A method for reducing power consumption on a wireless communication device is described. The wireless communication device includes a first stage active filter and a second stage active filter. A condition measurement is obtained that includes a signal measurement condition. If it is determined that the condition measurement is above a threshold, the second stage active filter is bypassed. | 09-18-2014 |
20150015343 | DEVICES AND METHODS FOR REDUCING NOISE IN DIGITALLY CONTROLLED OSCILLATORS - One feature pertains to a digitally controlled oscillator (DCO) that comprises a variable capacitor and noise reduction circuitry. The variable capacitor has a variable capacitance value that controls an output frequency of the DCO. The variable capacitance value is based on a first bank capacitance value provided by a first capacitor bank, a second bank capacitance value provided by a second capacitor bank, and an auxiliary bank capacitance value provided by an auxiliary capacitor bank. The noise reduction circuitry is adapted to adjust the variable capacitance value by adjusting the auxiliary bank capacitance value while maintaining at least one of the first bank capacitance value and/or the second bank capacitance value substantially unchanged. Prior to adjusting the variable capacitance value, the noise reduction circuitry may determine that a received input DCO control word transitions across a capacitor bank sensitive boundary. | 01-15-2015 |