Patent application number | Description | Published |
20090069519 | COBALT-CATALYZED ASYMMETRIC CYCLOPROPANATION OF ELECTRON-DEFICIENT OLEFINS - Cobalt-catalyzed asymmetric cyclopropanation of electron-deficient olefins. | 03-12-2009 |
20100063277 | Intramolecular C-H amination with sulfonyl azides - Cobalt (II) complexes of porphyrins are effective catalysts for intramolecular nitrene insertion of C—H bonds with arylsulfonyl azides. The cobalt-catalyzed process can proceed efficiently under mild and neutral conditions in low catalyst loading without the need of other reagents or additives, generating nitrogen gas as the only byproduct. Using the simple tetraphenylporphyrin (TPP) as the ligand, the cobalt-catalyzed intramolecular amidation can be applied to primary, secondary, and tertiary C—H bonds and suitable for a broad range of arylsulfonyl azides, leading to the syntheses of various benzosultam derivatives in excellent yields | 03-11-2010 |
20100076239 | ASYMMETRIC CYCLOPROPANATION OF ELECTRON-DEFICIENT OLEFINS WITH DIAZO REAGENTS - Cobalt-catalyzed asymmetric cyclopropanation of electron-deficient olefins. | 03-25-2010 |
20100081838 | Cobalt-Catalyzed Asymmetric Cyclopropanation of Alkenes with alpha-Nitrodiazoacetates - A process for the cyclopropanation of olefins with a metal porphyrin catalyst and an acceptor/acceptor substituted diazo reagent. | 04-01-2010 |
20100174104 | COBALT-CATALYZED ASYMMETRIC CYCLOPROPANATION WITH DIAZOSULFONES - Asymmetric cyclopropanation of olefins with diazosulfones. | 07-08-2010 |
20110112288 | Metal Porphyrin Catalyzed Olefin Aziridination with Sulfonyl Azides - Cobalt(II) complex of P1 [Co(P1)], a new porphyrin that was designed on the basis of potential hydrogen bonding interactions in the metal-nitrene intermediate, is a highly active catalyst for olefin aziridination with azides. The [Co(P1)]-based system can be effectively employed for different combinations of aromatic olefins and arysulfonyl azides, synthesizing various sulfonylated aziridines in excellent yields. Besides its mild catalytic conditions, the Co-catalyzed aziridination process enjoys several attributes associated with the relatively low cost of cobalt and widely accessible arylsulfonyl azides. Furthermore, it generates stable dinitrogen as the only by-product. | 05-12-2011 |
20110207956 | INTRAMOLECULAR C-H AMINATION WITH PHOSPHORYL AZIDES - A highly effective Co(II)-based system has been developed for catalytic intramolecular C—H amination with phosphoryl azides without the need of terminal oxidant or other additives, resulting in the high-yielding production of cyclophosphoramidates with nitrogen gas as the by-product; additional features of this new catalytic system include the amination of primary C—H bonds and formation of 7-membered ring structures. | 08-25-2011 |
20120046455 | Catalytic Cyclopropanation of Alkenes with Alpha-Cyano-Diazoacetates - A process for the preparation of a 1,1-cyclopropane(nitrile)(electron-acceptor), the process comprising treating an olefin with an acceptor/acceptor-substituted α-cyanodiazo reagent in the presence of a catalytic amount of a metal porphyrin catalyst. | 02-23-2012 |
20120077959 | Asymmetric Cobalt-Catalyzed Cyclopropanation With Succinimidyl Diazoacetate - Cobalt(II) complexes of the D | 03-29-2012 |
20120077990 | Alkene Aziridination - A process for the asymmetric aziridination of an alkene comprising treating the alkene with a sulfonyl azide, preferably trichloroethoxysulfonyl azide, in the presence of a cobalt(II) porphyrin. | 03-29-2012 |
20120101271 | DIAMINE SYNTHESIS VIA CATALYTIC C-H AMINATION OF AZIDES - Selective intramolecular C—H amination via metalloradical activation of azides: synthesis of 1,3-diamines under neutral and nonoxidative conditions. One aspect of the present invention is the synthesis of 1,3-diamines by intramolecular C—H amination of sulfamoyl azides. More specifically, sulfamoyl azides may be selectively aminated via metalloradical activation of azides, preferably with Co(II) porphyrins. In a particularly preferred embodiment, the Co(II) porphyrin is a D | 04-26-2012 |
20130030170 | ENANTIOSELECTIVE CYCLOPROPENATION OF ALKYNES - The cobalt(II) complex of new D2-symmetric chiral porphyrin 3,5-DiMes-ChenPhyrin, [Co(P2)], has been shown to be a highly effective chiral metalloradical catalyst for enantioselective cyclopropenation of alkynes with acceptor/acceptor-substituted diazo reagents such as α-cyanodiazoacetamides and α-cyanodiazoacetates. The [Co(P2)]-mediated metalloradical cyclopropenation is suitable to a wide range of terminal aromatic and related conjugated alkynes with varied steric and electronic properties, providing the corresponding tri-substituted cyclopropenes in high yields with excellent enantiocontrol of the all-carbon quaternary stereogenic centers. In addition to mild reaction conditions, the Co(II)-based metalloradical catalysis for cyclopropenation features a high degree of functional group tolerance. | 01-31-2013 |