Patent application number | Description | Published |
20120197439 | INTERFACING WITH A MOBILE TELEPRESENCE ROBOT - A telepresence robot may include a drive system, a control system, an imaging system, and a mapping module. The mapping module may access a plan view map of an area and tags associated with the area. In various embodiments, each tag may include tag coordinates and tag information, which may include a tag annotation. A tag identification system may identify tags within a predetermined range of the current position and the control system may execute an action based on an identified tag whose tag information comprises a telepresence robot action modifier. The telepresence robot may rotate an upper portion independent from a lower portion. A remote terminal may allow an operator to control the telepresence robot using any combination of control methods, including by selecting a destination in a live video feed, by selecting a destination on a plan view map, or by using a joystick or other peripheral device. | 08-02-2012 |
20120197464 | INTERFACING WITH A MOBILE TELEPRESENCE ROBOT - A telepresence robot may include a drive system, a control system, an imaging system, and a mapping module. The mapping module may access a plan view map of an area and tags associated with the area. In various embodiments, each tag may include tag coordinates and tag information, which may include a tag annotation. A tag identification system may identify tags within a predetermined range of the current position and the control system may execute an action based on an identified tag whose tag information comprises a telepresence robot action modifier. The telepresence robot may rotate an upper portion independent from a lower portion. A remote terminal may allow an operator to control the telepresence robot using any combination of control methods, including by selecting a destination in a live video feed, by selecting a destination on a plan view map, or by using a joystick or other peripheral device. | 08-02-2012 |
20130226344 | Mobile Robot - A mobile robot including a robot body, a drive system supporting the robot body, and a controller in communication with the drive system. The robot also includes an actuator moving a portion of the robot body through a volume of space adjacent the mobile robot and a sensor pod in communication with the controller. The sensor pod includes a collar rotatably supported and having a curved wall formed at least partially as a surface of revolution about a vertical axis. The sensor pod also includes a volumetric point cloud sensor housed by the collar and observing the volume of space adjacent the robot from within the collar along an observation axis extending through the curved wall. A collar actuator rotates the collar and the volumetric point cloud sensor together about the collar axis. | 08-29-2013 |
20130325244 | TIME-DEPENDENT NAVIGATION OF TELEPRESENCE ROBOTS - A telepresence robot may include a drive system, a control system, an imaging system, and a mapping module. The mapping module may access a plan view map of an area and tags associated with the area. In various embodiments, each tag may include tag coordinates and tag information, which may include a tag annotation. A tag identification system may identify tags within a predetermined range of the current position and the control system may execute an action based on an identified tag whose tag information comprises a telepresence robot action modifier. The telepresence robot may rotate an upper portion independent from a lower portion. A remote terminal may allow an operator to control the telepresence robot using any combination of control methods, including by selecting a destination in a live video feed, by selecting a destination on a plan view map, or by using a joystick or other peripheral device. | 12-05-2013 |
20140207286 | INTERFACING WITH A MOBILE TELEPRESENCE ROBOT - A telepresence robot may include a drive system, a control system, an imaging system, and a mapping module. The mapping module may access a plan view map of an area and tags associated with the area. In various embodiments, each tag may include tag coordinates and tag information, which may include a tag annotation. A tag identification system may identify tags within a predetermined range of the current position and the control system may execute an action based on an identified tag whose tag information comprises a telepresence robot action modifier. The telepresence robot may rotate an upper portion independent from a lower portion. A remote terminal may allow an operator to control the telepresence robot using any combination of control methods, including by selecting a destination in a live video feed, by selecting a destination on a plan view map, or by using a joystick or other peripheral device. | 07-24-2014 |
20150077502 | GRAPHICAL USER INTERFACES INCLUDING TOUCHPAD DRIVING INTERFACES FOR TELEMEDICINE DEVICES - The present disclosure describes various aspects of remote presence interfaces (RPIs) for use on portable electronic devices (PEDs) to interface with remote telepresence devices. An RPI may allow a user to interact with a telepresence device, view a live video feed, provide navigational instructions, and/or otherwise interact with the telepresence device. The RPI may allow a user to manually, semi-autonomously, or autonomously control the movement of the telepresence device. One or more panels associated with a video feed, patient data, calendars, date, time, telemetry data, PED data, telepresence device data, healthcare facility information, healthcare practitioner information, menu tabs, settings controls, and/or other features may be utilized via the RPI. | 03-19-2015 |
20150088310 | SOCIAL BEHAVIOR RULES FOR A MEDICAL TELEPRESENCE ROBOT - Devices, systems, and methods for social behavior of a telepresence robot are disclosed herein. A telepresence robot may include a drive system, a control system, an object detection system, and a social behaviors component. The drive system is configured to move the telepresence robot. The control system is configured to control the drive system to drive the telepresence robot around a work area. The object detection system is configured to detect a human in proximity to the telepresence robot. The social behaviors component is configured to provide instructions to the control system to cause the telepresence robot to operate according to a first set of rules when a presence of one or more humans is not detected and operate according to a second set of rules when the presence of one or more humans is detected. | 03-26-2015 |
Patent application number | Description | Published |
20120094326 | IMAGING AND EVALUATING EMBRYOS, OOCYTES, AND STEM CELLS - Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans. | 04-19-2012 |
20120095287 | IMAGING AND EVALUATING EMBRYOS, OOCYTES, AND STEM CELLS - Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans. | 04-19-2012 |
20130162795 | IMAGING AND EVALUATING EMBRYOS, OOCYTES, AND STEM CELLS - Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans. | 06-27-2013 |
20130165745 | IMAGING AND EVALUATING EMBRYOS, OOCYTES, AND STEM CELLS - Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans. | 06-27-2013 |
Patent application number | Description | Published |
20110127203 | Disposable Tangential Flow Filtration Liner With Sensor Mount - Tangential flow filtration device is provided wherein liners are provided between the filtration element and the top and bottom holders or manifolds. The liners incorporate the flow channels and inlet and outlet ports, as well as a sensor mount. The liners are made of an inexpensive material and therefore are disposable after a single use, making it more cost effective to dispose of them than to clean the conventional manifolds. The sensor mount accommodates a removable sensor, and isolates it from the fluid path. | 06-02-2011 |
20110174711 | Self Contained Disposable Tangential Flow Filtration Liner - Tangential flow filtration device is provided wherein liners are provided between the filtration element and the top and bottom holders or manifolds. The liners incorporate the flow channels and inlet and outlet ports, as well as an optional sensor mount. The liners and filtration element are independently compressed, so that decompression of the overall assembly does not decompress the liners and filtration element, thereby preventing leakage of hold-up volume within the fluid paths of the filtration element and liners. | 07-21-2011 |
20130233777 | Disposable Tangential Flow Filtration Liner with Sensor Mount - Tangential flow filtration device is provided wherein liners are provided between the filtration element and the top and bottom holders or manifolds. The liners incorporate the flow channels and inlet and outlet ports, as well as a sensor mount. The liners are made of an inexpensive material and therefore are disposable after a single use, making it more cost effective to dispose of them than to clean the conventional manifolds. The sensor mount accommodates a removable sensor, and isolates it from the fluid path. | 09-12-2013 |
Patent application number | Description | Published |
20100012665 | Container having vortex breaker and fluid diverter and system - A disposable container for fluid is provided. The container has a vortex breaker positioned adjacent the container outlet and a fluid diverter positioned adjacent each inlet to the container. | 01-21-2010 |
20100012666 | Container having vortex breaker and system - A disposable container for fluid having an inlet and an outlet is provided. The container has a vortex breaker having a solid surface adapted to initially direct fluid away from the outlet and then through the outlet positioned adjacent the container outlet. | 01-21-2010 |
20100175393 | Biomaterial Freezing - The biocontainer of the present invention provides a low cost, simple solution of many of the problems encountered during shipping, freezing and thawing of biopharmaceutical materials. The present invention enables a user to monitor the temperature profile of each biopharmaceutical container during the cryogenic process, so as to ensure the integrity of materials within each biocontainer by using a pre-installed and pre-sterilized temperature sensor. In some embodiments, the sensor assembly includes a wireless transmitter and is capable of transmitting information regarding the measured reading. In other embodiments, the sensor assembly includes a processing unit, which determines whether the temperature profile is acceptable. In a further embodiment, an indicator is included, such that the processing unit may indicate whether the biopharmaceutical material has been properly frozen. In other embodiments, the sensor assembly also includes a storage element, which is capable of storing various parameters during the freezing process. | 07-15-2010 |
20110085746 | FEED BAG CONSTRUCTION - A feed bag construction is provided comprising a feed bag, a first conduit sealed to the feed bag, a second conduit sealed to the interior of the feed bag for supplying wash reagent to the feed bag and a one piece cap that is removably mounted on the first conduit. The first conduit is provided with a hand operated butterfly valve to open or close the conduit. | 04-14-2011 |
20110235948 | FLEXIBLE PINCH FITTING FOR CONTAINERS - A device for reducing or eliminating the dead space in a fitting and tubing used on a disposable container by using a flexible elastic fitting that can accommodate a pinch valve or a clamp or the like closer to the flange portion of the fitting. The fitting is formed of a flange and a neck portion with a bore running through them. The neck may terminate in either a tubular section or a hose barb. The neck end section especially when in the form of a hose barb can be reinforced to provide a platform for attaching a tubing to it. | 09-29-2011 |
20110249526 | PROCESS BAG CONTAINER WITH SENSORS - A process bag container is provided comprising a flexible bag, at least one inlet sealed to the bag, and an outlet. A probe housing for a probe construction is sealed to the bag. Preferably, the probe housing extends at least partway into the bag interior and is connected to a cable for power and data transmission that runs along the outer surface of the bag to the top of the bag or its support container. The probe construction is adapted to monitor the composition of a reagent in the bag as well as the environment within the bag. A mixer is positioned within the bag to effect mixing of reagents in the bag. | 10-13-2011 |
20130038469 | Biomaterial Freezing - The biocontainer of the present invention provides a low cost, simple solution of many of the problems encountered during shipping, freezing and thawing of biopharmaceutical materials. The present invention enables a user to monitor the temperature profile of each biopharmaceutical container during the cryogenic process, so as to ensure the integrity of materials within each biocontainer by using a pre-installed and pre-sterilized temperature sensor. In some embodiments, the sensor assembly includes a wireless transmitter and is capable of transmitting information regarding the measured reading. In other embodiments, the sensor assembly includes a processing unit, which determines whether the temperature profile is acceptable. In a further embodiment, an indicator is included, such that the processing unit may indicate whether the biopharmaceutical material has been properly frozen. In other embodiments, the sensor assembly also includes a storage element, which is capable of storing various parameters during the freezing process. | 02-14-2013 |
20130039382 | Biomaterial Freezing - The biocontainer of the present invention provides a low cost, simple solution of many of the problems encountered during shipping, freezing and thawing of biopharmaceutical materials. The present invention enables a user to monitor the temperature profile of each biopharmaceutical container during the cryogenic process, so as to ensure the integrity of materials within each biocontainer by using a pre-installed and pre-sterilized temperature sensor. In some embodiments, the sensor assembly includes a wireless transmitter and is capable of transmitting information regarding the measured reading. In other embodiments, the sensor assembly includes a processing unit, which determines whether the temperature profile is acceptable. In a further embodiment, an indicator is included, such that the processing unit may indicate whether the biopharmaceutical material has been properly frozen. In other embodiments, the sensor assembly also includes a storage element, which is capable of storing various parameters during the freezing process. | 02-14-2013 |
Patent application number | Description | Published |
20080261593 | Systems and methods for IMS user sessions with dynamic service selection - Under one aspect, a system generates dynamic call models within an IMS network, allowing different user entities (UEs) to have different service experiences. The IMS network includes application servers (ASs) and a serving call state control function (S-CSCF) that receives and then forwards UE service requests. The system includes storage media storing a service tree, which defines potential call models that map potential UE service requests onto ASs. At least two potential call models map a specified potential UE service request onto different ASs that can provide different service experiences. The system includes control logic for providing session control, which receives UE service requests from the S-CSCF, receives the service tree from the storage media, generates a call model for each UE based on potential call models defined by the service tree and on the requested service, and invokes a specified AS based on the generated call model. | 10-23-2008 |
20110092206 | SYSTEMS AND METHODS FOR IMS USER SESSIONS WITH DYNAMIC SERVICE SELECTION - Under one aspect, a system generates dynamic call models within an IMS network, allowing different user entities (UEs) to have different service experiences. The IMS network includes application servers (ASs) and a serving call state control function (S-CSCF) that receives and then forwards UE service requests. The system includes storage media storing a service tree, which defines potential call models that map potential UE service requests onto ASs. At least two potential call models map a specified potential UE service request onto different ASs that can provide different service experiences. The system includes control logic for providing session control, which receives UE service requests from the S-CSCF, receives the service tree from the storage media, generates a call model for each UE based on potential call models defined by the service tree and on the requested service, and invokes a specified AS based on the generated call model. | 04-21-2011 |
20110151871 | IMS NETWORKS WITH AVS SESSIONS WITH MULTIPLE ACCESS NETWORKS - IMS networks with AVS sessions with multiple access networks. Systems and methods associate multiple access network sessions with a given user endpoint (UE) device. A UE is managed in an IMS network to have multiple concurrent sessions to corresponding access networks. An application server in the IMS network creates a computer-implemented representation of an audio video session (AVS). The AVS representation includes a first incoming leg (ICL) to represent at least the initial access network to which the UE has access. Subsequently, it is determined that the UE can access a different access network than the initial access network. The different access network is of different type than the initial access network. | 06-23-2011 |
20110164563 | Method of Avoiding or Minimizing Cost of Stateful Connections Between Application Servers and S-CSCF Nodes in an IMS Network with Multiple Domains - Methods of avoiding or minimizing cost of stateful connections between application servers (ASs) and S-CSCF nodes in an IMS network with multiple domains. S-CSCF service logic is provided and connected to a co-located AS. The IMS includes a network operator administration domain and an MVNO service domain, and the S-CSCF logic and AS are maintained in the same domain, e.g., the MVNO or network operator domain. | 07-07-2011 |
20120036248 | ASSOCIATED DEVICE DISCOVERY IN IMS NETWORKS - A method of associating multiple user endpoints (UEs) with a single IMS session in an IMS network having a serving node for controlling at least one IMS session for a user and at least a first access network for providing access to UEs. The method involves associating a first UE with the user and with an IMS session; discovering a second UE in a proximity of the first UE; discovering information about the second UE; communicating the information about the second UE to the serving node; the serving node utilizing computer-implemented policy logic to determine whether to associate the second UE with the user and the IMS session; and if the policy logic determines that the second UE is to be associated, the serving node associating the second UE with the IMS session while retaining the association with the first UE. | 02-09-2012 |
20120063582 | System and method to provide dynamic call models for users in a network - A system and method provisions dynamic call models within a network having a serving node for providing session control for user endpoint (UE) devices. A user endpoint device (UE) with agent logic, expresses dynamic context of the UE in a message and sends said dynamic context message to a serving node. The dynamic context includes a subset of devices that could be used as UEs or associated devices, network connections that terminate or emanate from said devices that could be used as UEs or associated devices, and capabilities of said devices that could be used as UEs or associated devices. The serving node logic receives said context message from the UE and constructs a dynamic call model in response. The dynamic call model having filter codes to associate service codes with application servers (ASs) in communication with the network, and each AS having service logic to provide a service. | 03-15-2012 |
20120214452 | SYSTEMS AND METHODS FOR USER SESSIONS WITH DYNAMIC SERVICE SELECTION - Under one aspect, a system generates dynamic call models within a network, allowing different user entities (UEs) to have different service experiences. The network includes application servers (ASs) and a switch that receives and then forwards UE service requests. The system includes storage media storing hierarchically organized data, which defines potential call models that map potential UE service requests onto ASs. At least two potential call models map a specified potential UE service request onto different ASs that can provide different service experiences. The system includes control logic for providing session control, which receives UE service requests from the switch, receives the hierarchically organized data from the storage media, generates a call model for each UE based on potential call models defined by the hierarchically organized data and on the requested service, and invokes a specified AS based on the generated call model. | 08-23-2012 |
20130301557 | SYSTEMS AND METHODS FOR USER SESSIONS WITH DYNAMIC SERVICE SELECTION - Under one aspect, a system generates dynamic call models within a network, allowing different user entities (UEs) to have different service experiences. The network includes application servers (ASs) and a switch that receives and then forwards UE service requests. The system includes storage media storing hierarchically organized data, which defines potential call models that map potential UE service requests onto ASs. At least two potential call models map a specified potential UE service request onto different ASs that can provide different service experiences. The system includes control logic for providing session control, which receives UE service requests from the switch, receives the hierarchically organized data from the storage media, generates a call model for each UE based on potential call models defined by the hierarchically organized data and on the requested service, and invokes a specified AS based on the generated call model. | 11-14-2013 |
Patent application number | Description | Published |
20110204460 | Integrated Hall Effect Element Having a Germanium Hall Plate - An integrated circuit and a method of making the integrated circuit provide a Hall effect element having a germanium Hall plate. The germanium Hall plate provides an increased electron mobility compared with silicon, and therefore, a more sensitive Hall effect element. | 08-25-2011 |
20140264678 | PACKAGING FOR AN ELECTRONIC DEVICE - In one aspect, a method includes processing a metal substrate, performing a first etch on a first surface of the metal substrate to form, for an integrated circuit package, secondary leads and a curved component having two primary leads and performing a second etch, on a second surface of the substrate opposite the first surface, at locations on the secondary leads and locations on the curved component to provide a locking mechanism. Each primary lead located at a respective end of the curved component. | 09-18-2014 |
20150061069 | INTEGRATING A CAPACITOR IN AN INTEGRATED CIRCUIT - In one aspect, an integrated circuit (IC) includes an isolation trench dividing the IC into a first section and a second section, an active electronic device disposed in the first section of the IC and a capacitor disposed in the second section of the IC and electrically isolated from the active electronic device. | 03-05-2015 |
Patent application number | Description | Published |
20100116872 | ADJUSTABLE TAB FOLDER - Embodiments described herein relate to dividers and folders with tabs adjustable along at least two edges thereof. One embodiment is directed to a folder comprising a first panel, a second panel coupled to the first panel, at least one tab mating feature associated with the second panel, and a tab configured to mate with the at least one tab mating feature. The at least one tab mating feature is configured such that the tab is positionable in at least two positions along a first axis adjacent a first edge of the second panel and in at least two positions along a second axis adjacent a second edge of the second panel, wherein the first axis is transverse to the second axis. | 05-13-2010 |
20100119292 | ADJUSTABLE TAB DIVIDER - Embodiments of the invention relate to dividers with tabs adjustable along at least two edges of the binder. One embodiment is directed to a divider for use in a binder. The divider comprises a panel, the panel comprising a binding edge and a plurality of non-binding edges, and a tab. The panel comprises at least one binding feature adjacent the binding edge and at least one tab mating feature adjacent at least first and second edges of the plurality of non-binding edges. The tab is configured to mate with the at least one tab mating feature. The at least one tab mating feature is configured such that the tab is positionable in at least two longitudinal positions along the first non-binding edge and in at least two longitudinal positions along the second non-binding edge. | 05-13-2010 |
20100209177 | ADJUSTABLE TAB DIVIDER - Embodiments of the invention relate to dividers with tabs adjustable along at least two edges of the binder. One embodiment is directed to a divider for use in a binder. The divider comprises a panel, the panel comprising a binding edge and a plurality of non-binding edges, and a tab. The panel comprises at least one binding feature adjacent the binding edge and at least one tab mating feature adjacent at least first and second edges of the plurality of non-binding edges. The tab is configured to mate with the at least one tab mating feature. The at least one tab mating feature is configured such that the tab is positionable in at least two longitudinal positions along the first non-binding edge and in at least two longitudinal positions along the second non-binding edge. | 08-19-2010 |
20120098246 | REPOSITIONABLE NOTEBOOK ACCESSORIES - Embodiments are directed to repositionable notebook accessories and methods of using such accessories in connection with a notebook. The repositionable notebook accessory comprises a panel and at least one hook feature configured and arranged to couple the panel to a spine of a notebook when the at least one hook feature is at least partially disposed within the spine. The repositionable notebook accessory may comprise, for example, a divider, a folder and/or an adhesive flag holder. | 04-26-2012 |
Patent application number | Description | Published |
20100068854 | MEMS Switch Capping and Passivation Method - A MEMS switch with a platinum-series contact is capped through a process that also passivates the contact by controlling, over time, the amount of oxygen in the environment, pressures and temperatures. Some embodiments passivate a contact in an oxygenated atmosphere at a first temperature and pressure, before hermetically sealing the cap at a higher temperature and pressure. Some embodiments hermetically seal the cap at a temperature below which passivating dioxides will form, thus trapping oxygen within the volume defined by the cap, and later passivate the contact with the trapped oxygen at a higher temperature. | 03-18-2010 |
20110287586 | MEMS Switch Capping and Passivation Method - A MEMS switch with a platinum-series contact is capped through a process that also passivates the contact by controlling, over time, the amount of oxygen in the environment, pressures and temperatures. Some embodiments passivate a contact in an oxygenated atmosphere at a first temperature and pressure, before hermetically sealing the cap at a higher temperature and pressure. Some embodiments hermetically seal the cap at a temperature below which passivating dioxides will form, thus trapping oxygen within the volume defined by the cap, and later passivate the contact with the trapped oxygen at a higher temperature. | 11-24-2011 |
20130032454 | MICRO-ELECTRO-MECHANICAL SWITCH BEAM CONSTRUCTION WITH MINIMIZED BEAM DISTORTION AND METHOD FOR CONSTRUCTING - Disclosed is a micro-electro-mechanical switch, including a substrate having a gate connection, a source connection, a drain connection and a switch structure, coupled to the substrate. The switch structure includes a beam member, an anchor and a hinge. The beam member having a length sufficient to overhang both the gate connection and the drain connection. The anchor coupling the switch structure to the substrate, the anchor having a width. The hinge coupling the beam member to the anchor at a respective position along the anchor's length, the hinge to flex in response to a charge differential established between the gate and the beam member. The switch structure having gaps between the substrate and the anchor in regions proximate to the hinges. | 02-07-2013 |
20140115873 | MICRO-ELECTRO-MECHANICAL SWITCH BEAM CONSTRUCTION WITH MINIMIZED BEAM DISTORTION AND METHOD FOR CONSTRUCTING - Disclosed is a micro-electro-mechanical switch, including a substrate having a gate connection, a source connection, a drain connection and a switch structure, coupled to the substrate. The switch structure includes a beam member, an anchor and a hinge. The beam member having a length sufficient to overhang both the gate connection and the drain connection. The anchor coupling the switch structure to the substrate, the anchor having a width. The hinge coupling the beam member to the anchor at a respective position along the anchor's length, the hinge to flex in response to a charge differential established between the gate and the beam member. The switch structure having gaps between the substrate and the anchor in regions proximate to the hinges. | 05-01-2014 |
Patent application number | Description | Published |
20090297525 | Compositions, kits and methods for identification, assessment, prevention and therapy of cancer - The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human cancer. A variety of chromosomal regions (MCRs) and markers corresponding thereto, are provided, wherein alterations in the copy number of one or more of the MCRs and/or alterations in the amount, structure, and/or activity of one or more of the markers is correlated with the presence of cancer. | 12-03-2009 |
20100166744 | USE OF ANTI-EGFR ANTIBODIES IN TREATMENT OF EGFR MUTANT MEDIATED DISEASE - The present invention relates to the treatment of EGFR-mediated disease, particularly cancer, which is resistant to tyrosine kinase inhibitor therapies. Methods for treatment of cancer and reduction of tumor growth in individuals with secondary EGFR mutations, particularly tyrosine kinase domain mutations, resistant to standard therapy are provided. The invention provides methods for the treatment of tyrosine kinase inhibitor resistant cancers with anti-EGFR antibodies. Methods for treatment of recurrent lung cancer, including non-small cell lung carcinoma which is resistant to tyrosine kinase inhibitors, with the antibody anti-EGFR mAb806 are described. | 07-01-2010 |
20110119776 | METHODS OF DIAGNOSING AND PROGNOSING LUNG CANCER - The present invention provides methods of detecting cancer using biomarkers. | 05-19-2011 |
20110319415 | Susceptibility to HSP90-Inhibitors - The present invention relates to a method of selecting (a) cell(s), (a) tissue(s) or (a) cell culture(s) with susceptibility to an HSP90 inhibitor. Also a method for determining the responsiveness of a mammalian tumor cell or cancer cell to treatment with an HSP90 inhibitor is described herein. In particular, the present invention provides for an in vitro method for the identification of a responder for or a patient sensitive to an HSP90 inhibitor and uses of an oligo- or polynucleotide capable of detecting (an) activating mutation(s) in the KRAS gene are provided. The present invention also relates to a method of monitoring the efficacy of a treatment of a cancer characterized by the presence of at least one activating mutation in the KRAS gene, and. optionally, in the EGFR gene and/or the BRAF gene. In addition, a method of predicting the efficacy of a cancer treatment is described, in particular in a cancer that is characterized by the presence of at least one activating mutation in the KRAS gene. and. optionally, in the EGFR gene and/or the BRAF gene. Also the use of a (transgenic) non-human animal or a (transgenic) cell having at least one activating mutation in the KRAS gene, and, optionally, in the EGFR gene and/or the BRAF gene for screening and/or validation of a medicament for the treatment of said cancer is described and a kit useful for carrying out the methods described herein is provided. | 12-29-2011 |
20130023420 | SUSCEPTIBILITY TO HSP90-INHIBITORS - The present invention relates to a combination of cell lines as well as a method of selecting (a) cell(s), (a) tissue(s) or (a) cell culture(s) with susceptibility to an HSP90 inhibitor anti-tumor agent. Also a method for determining the responsiveness of a mammalian tumor cell or cancer cell or collection of cells or cell lines to treatment with a drug such as an HSP90 inhibitor anti-tumor agent is described herein. | 01-24-2013 |
20130303543 | PROTECTION OF RENAL TISSUES FROM ISCHEMIA THROUGH INHIBITION OF THE PROLIFERATIVE KINASES CDK4 AND CDK6 - The presently disclosed subject matter relates to methods and compositions for protecting cells and or tissues from damage due to ischemia. In particular, the presently disclosed subject matter relates to the protective action of cyclin dependent kinase 4/6 (CDK4/6) lithibitors administered to subjects that have been exposed to, or that are at risk of, ischemia. | 11-14-2013 |
20140314791 | METHODS OF TREATING CANCER - The present invention provides methods of treating cancer, particularly cancers that are null or have decreased expression or activity of the Lkb1 gene. Also included are methods of identifying therapeutic targets for the treatment of cancer. | 10-23-2014 |
20140378469 | LKB1/STK11 DELETION IN MELANOMA AND RELATED METHODS - LKB1 mutation status and/or expression, YES expression and phosphorylation level; and/or CD24 expression are employed to predict melanoma prognosis and response to therapeutics. Inhibitors (including targeted inhibitors) of SRC family kinases (especially YES) are employed to treat melanoma. | 12-25-2014 |
Patent application number | Description | Published |
20080280360 | Method for Producing Biomaterial Scaffolds - The present invention provides a multilayer scaffold for tissue engineering. The scaffold comprises at least a first layer comprised of a polymer having a pattern of microchannels therein; and at least a second layer comprised of a polymer having a pattern of microchannels therein. The first and second layers are joined together (preferably by lamination) and the channels are connected for the circulation of fluid through the layers. The scaffold is coated with bacterial cellulose. The scaffold may further include a mammalian cell. | 11-13-2008 |
20090298139 | Method for Polymer Synthesis Using Microfluidic Enzymatic Cascade - The present invention discloses a method for producing polymers in a microscale device. The system utilizes a symmetrically branched system of microchannels interconnecting a plurality of loading decks and re-action chambers. The fluid flow is manipulated by the placement of capillary check valves, mixing areas, and microcomb filters. The system provides for cascading enzymatic biosynthesis pathways wherein any variety of enzymes and reactants can be introduced into the system to produce a final product. | 12-03-2009 |
20100003158 | VIBRATORY POWDER CONSOLIDATION - A vibratory powder consolidation process is provided in which a powder material is subjected to vibratory energy while under static compressive loading. The process provides rapid, full-density powder consolidation with minimum or no structural degradation. | 01-07-2010 |
20110172519 | SYSTEMS, DEVICES AND METHODS EMPLOYING FIBER OPTIC SHAPE TRACKING - The present invention provides systems, devices, and methods employing fiber optic shape and position tracking. The systems, devices, and methods permit measurement of and continuous tracking of the shape and position of objects whose shape dynamically changes with time. Applications include tracking and monitoring of endoscopes for diagnostic and surgical procedures. | 07-14-2011 |
20120259211 | SYSTEMS, DEVICES, AND METHODS EMPLOYING FIBER OPTIC SHAPE TRACKING - The present invention provides systems, devices, and methods employing fiber optic shape and position tracking. The systems, devices, and methods permit measurement of and continuous tracking of the shape and position of objects whose shape dynamically changes with time. Applications include tracking and monitoring of endoscopes for diagnostic and surgical procedures. | 10-11-2012 |
Patent application number | Description | Published |
20110144760 | Patient-Specific and Patient-Engineered Orthopedic Implants - Disclosed herein are methods and devices for repairing a knee joint, including customizable and/or highly selectable implants and/or implant components for each patient to provide optimal fit and function. | 06-16-2011 |
20120041446 | Patient Selectable Joint Arthroplasty Devices and Surgical Tools Incorporating Anatomical Relief - Disclosed herein are methods, compositions and tools for repairing articular surfaces repair materials and for repairing an articular surface. The articular surface repairs are customizable or highly selectable by patient and geared toward providing optimal fit and function. The surgical tools are designed to be customizable or highly selectable by patient to increase the speed, accuracy and simplicity of performing total or partial arthroplasty. | 02-16-2012 |
20120209394 | Patient-Adapted and Improved Articular Implants, Designs and Related Guide Tools - Methods and devices are disclosed relating improved articular models, implant components, and related guide tools and procedures. In addition, methods and devices are disclosed relating articular models, implant components, and/or related guide tools and procedures that include one or more features derived from patient-data, for example, images of the patient's joint. The data can be used to create a model for analyzing a patient's joint and to devise and evaluate a course of corrective action. The data also can be used to create patient-adapted implant components and related tools and procedures. | 08-16-2012 |
20130211410 | Patella Resection Instrument Guide Having Optional Patient-Specific Features - Disclosed are improved and/or patient-adapted (e.g., patient-specific and/or patient-engineered) patellar clamp systems, surgical methods and related surgical tools. The various clamp assemblies can facilitate one-handed operation by a user and can include modular features that provide for ease of interchangeability to accommodate components having patient specific features that conform or substantially conform to the patient's patellar anatomy. | 08-15-2013 |
20140163568 | Patient Selectable Joint Arthroplasty Devices and Surgical Tools Incorporating Anatomical Relief - Disclosed herein are methods, compositions and tools for repairing articular surfaces repair materials and for repairing an articular surface. The articular surface repairs are customizable or highly selectable by patient and geared toward providing optimal fit and function. The surgical tools are designed to be customizable or highly selectable by patient to increase the speed, accuracy and simplicity of performing total or partial arthroplasty. | 06-12-2014 |
20150081029 | Advanced Methods, Techniques, Devices, and Systems for Cruciate Retaining Knee Implants - Improved implants, systems, tools and related methods for bi-cruciate retaining joint treatment are disclosed, including patient-adapted implants, systems, tools, and methods. | 03-19-2015 |
Patent application number | Description | Published |
20100130465 | 2-AMINOTHIAZOLE-4-CARBOXYLIC AMIDES AS PROTEIN KINASE INHIBITORS - The present invention relates to novel Anilinopiperazine Derivatives of formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase. | 05-27-2010 |
20100331313 | Thiazole Derivatives as Protein Kinase Inhibitors - The present invention relates to novel Thiazole Derivatives, compositions comprising the Thiazole Derivatives, and methods for using the Thiazole Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral infection, a fungal infection, or a disorder related to the activity of a protein kinase. | 12-30-2010 |
20120328691 | ANILINOPIPERAZINE DERIVATIVES AND METHODS OF USE THEREOF - The present invention relates to novel Anilinopiperazine Derivatives of Formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, cancer, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase. | 12-27-2012 |
Patent application number | Description | Published |
20100286135 | HETEROCYCLIC AMIDE COMPOUNDS AS PROTEIN KINASE INHIBITORS - The present invention relates to novel heterocyclic amide compounds of Formula I: as disclosed herein or a pharmaceutically acceptable salt, solvate, ester, prodrug or stereoisomer thereof. Also disclosed are compositions comprising said compounds, and methods for using said compounds for treating or preventing a proliferative disease, an anti-proliferative disorder, inflammation, arthritis, a neurological or neurodegenerative disease, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease or a fungal disease. | 11-11-2010 |
20120208826 | HETEROCYCLIC AMIDE COMPOUNDS AS PROTEIN KINASE INHIBITORS - The present invention relates to heterocyclic amide derivatives of Formula (I): Formula (I) wherein the variables are as defined in the specification. The present invention further relates to compositions comprising said heterocyclic amide derivatives of formula (I) and methods for using said heterocyclic amide derivatives of formula (I) for treating or preventing a disease or disorder related to the activity of a protein kinase, in particular, a proliferative disease, an anti-proliferative disorder, inflammation, arthritis, a neurological or neurodegenerative disease, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease or a fungal infection. | 08-16-2012 |
20130217682 | PYRAZOLOPYRIMIDINYL INHIBITORS OF UBIQUITIN-ACTIVATING ENZYME - Disclosed are chemical entities that inhibit ubiquitin-activating enzyme (UAE), each of which is a compound of Formula I: | 08-22-2013 |
20140088096 | PYRAZOLOPYRIMIDINYL INHIBITORS OF UBIQUITIN-ACTIVATING ENZYME - Disclosed are chemical entities that inhibit ubiquitin-activating enzyme (UAE), each of which is a compound of Formula I: | 03-27-2014 |
Patent application number | Description | Published |
20110193987 | METHODS, APPARATUS AND SYSTEMS FOR DETERMINING POWER SPECTRAL DENSITY OF A SIGNAL VIA MODULATION OF THE SIGNAL - Methods, apparatus and systems for determining a power spectral density (PSD) of a signal, in which modulation of the signal is employed to facilitate determination of one or more PSD values over a wide range of frequencies. In some implementations, the signal may represent a wide-sense stationary random process. In one example, the signal is measured/sampled during a plurality of measurement windows, during which an intensity of the signal is modulated at one or more modulation frequencies. A variance of a set of quantities determined from the signal samples is calculated and used to determine respective values of the power spectral density (PSD) for the signal at the one or more modulation frequencies. The one or more modulation frequencies may be chosen in excess of the Nyquist frequency of the sampling process, such that the signal may be characterized for one or more frequencies above the Nyquist limit. | 08-11-2011 |
20130130884 | APPARATUS FOR MEASUREMENT OF SPINNING FORCES RELATING TO MOLECULES - An apparatus for measuring a characteristic of a sample includes a sample measurement apparatus ( | 05-23-2013 |
20130288349 | SPINNING FORCE APPARATUS - A spinning force system and methods of operation are provided for measuring a characteristic of a sample. The system includes a detection module having a light source for illuminating the sample and an objective being aligned to the light source to define a light path for producing an image of the sample. A rotor is mechanically coupled to the detection module and configured to rotate the light path for applying a force to the sample. The force may include a centrifugal force and other forms of force (such as a viscous drag force) resulted from the rotation. In some examples, the force is applied in a direction that is not parallel to a surface of the sample. | 10-31-2013 |
20140255939 | NUCLEIC ACID-BASED LINKERS FOR DETECTING AND MEASURING INTERACTIONS - The invention provides compositions comprising nucleic acid complexes for use in monitoring binding interactions and in measuring association and/or dissociation kinetics with or without force, detecting analytes, screening aptamers, and encoding/encrypting information. In some instances, the nucleic acid complexes are double-stranded nicked nucleic acids comprising a scaffold nucleic acid hybridized to one or more oligonucleotides. In some instances, a first and/or a second oligonucleotide are linked to moieties that are known to interact with each other or which are suspected of interacting with each other. | 09-11-2014 |
Patent application number | Description | Published |
20120029357 | ULTRASOUND 3D IMAGING SYSTEM - The present invention relates to an ultrasound imaging system in which the scan head either includes a beamformer circuit that performs far field subarray beamforming or includes a sparse array selecting circuit that actuates selected elements. When used with second stage beamforming system, three dimensional ultrasound images can be generated. | 02-02-2012 |
20130102902 | ULTRASOUND 3D IMAGING SYSTEM - The present invention relates to an ultrasound imaging system in which the scan head either includes a beamformer circuit that performs far field subarray beamforming or includes a sparse array selecting circuit that actuates selected elements. When used with second stage beamforming system, three dimensional ultrasound images can be generated. | 04-25-2013 |
20130261463 | ULTRASOUND 3D IMAGING SYSTEM - The present invention related to an ultrasound imaging system win which the scan head includes a beamformer circuit that performs far field subarray beamforming or includes a sparse array selecting circuit that actuates selected elements. When using a hierarchical two-stage or three-stage beamforming system, three dimensional ultrasound images can be generated in real-time. The invention further relates to flexible printed circuit boards in the probe head. The invention furthermore related to the use. of coded or spread spectrum signaling in ultrasound imagining systems. Matched filters based on pulse compression using Golay code pairs improve the signal-to-noise ratio thus enabling third harmonic imaging with suppressed sidelobes. The system is suitable for 3D full volume cardiac imaging. | 10-03-2013 |
20140051984 | ULTRASOUND PROBE WITH INTEGRATED ELECTRONICS - A hand-held ultrasound system includes integrated electronics within an ergonomic housing. The electronics includes control circuitry, beamforming and circuitry transducer drive circuitry. The electronics communicate with a host computer using an industry standard high speed serial bus. The ultrasonic imaging system is operable on a standard, commercially available, user computing device without specific hardware modifications, and is adapted to interface with an external application without modification to the ultrasonic imaging system to allow a user to gather ultrasonic data on a standard user computing device such as a PC, and employ the data so gathered via an independent external application without requiring a custom system, expensive hardware modifications, or system rebuilds. An integrated interface program allows such ultrasonic data to be invoked by a variety of such external applications having access to the integrated interface program via a standard, predetermined platform such as visual basic or c | 02-20-2014 |
20140071789 | MODULAR PORTABLE ULTRASOUND SYSTEMS - The present invention relates to a lightweight, high resolution portable ultrasound system using components and methods to improve connectivity and ease of use. A preferred embodiment includes an integrated system in which the beamformer control circuitry can be inserted into the host computer as a peripheral or within the processor housing. | 03-13-2014 |
20140114190 | TABLET ULTRASOUND SYSTEM - Exemplary embodiments provide systems and methods for portable medical ultrasound imaging. Certain embodiments provide a multi-chip module for an ultrasound engine of a portable medical ultrasound imaging system, in which a transmit/receive chip, an amplifier chip and a beamformer chip are assembled in a vertically stacked configuration. Exemplary embodiments also provide an ultrasound engine circuit board including one or more multi-chip modules, and a portable medical ultrasound imaging system including an ultrasound engine circuit board with one or more multi-chip modules. Exemplary embodiments also provide methods for fabricating and assembling multi-chip modules as taught herein. A single circuit board of an ultrasound engine with one or more multi-chip modules may include 16 to 128 channels in some embodiments. Due to the vertical stacking arrangement of the multi-chip modules, a 128-channel ultrasound engine circuit board can be assembled within exemplary planar dimensions of about 10 cm×about 10 cm. | 04-24-2014 |
20140121524 | TABLET ULTRASOUND SYSTEM - Exemplary embodiments provide systems and methods for portable medical ultrasound imaging. Preferred embodiments utilize a tablet touchscreen display operative to control imaging and display operations without the need for using traditional keyboards or controls. Certain embodiments provide ultrasound imaging system in which the scan head includes a beamformer circuit that performs far field sub array beamforming or includes a sparse array selecting circuit that actuates selected elements. Exemplary embodiments also provide an ultrasound engine circuit board including one or more multi-chip modules, and a portable medical ultrasound imaging system including an ultrasound engine circuit board with one or more multi-chip modules. Exemplary embodiments also provide methods for using a hierarchical two-stage or three-stage beamforming system, three dimensional ultrasound images which can be generated in real-time. | 05-01-2014 |
Patent application number | Description | Published |
20100067972 | GRILL CLEANING UTENSIL - A cleaning utensil is disclosed having a housing comprised of a cleaning portion and a handle portion. The housing has a reservoir and a pump. The reservoir is adapted to contain a fluid. The cleaning portion has a scrubbing surface and an orifice, and the handle portion has an actuator. The pump communicates with the reservoir, the orifice, and the actuator; whereby actuation of the actuator causes the fluid to be drawn from the reservoir and exhausted from the orifice by the pump. The orifice is arranged and adapted to cause the fluid to be exhausted forwardly from the cleaning portion. A bristled scrubbing element is removably affixable to the cleaning portion and has a scrubbing surface extending up first and second opposite side surfaces of the cleaning portion and across a bottom surface of the cleaning portion from the first side to the second side. | 03-18-2010 |
20140199111 | Ring Binder Mechanism - A ring binder mechanism has an elongate housing, a pair of locking elements, a translation bar, a pair of elongate hinge plates having mating ring halves extending there-from, a plurality of mating ring halves, and an actuator. Movement of the actuator moves the hinge plates, translation bar, and locking elements to cause the ring halves to disengage so a user can place holed paper over the open ring halves, or closes the ring halves together to secure the paper with the closed-loop rings thus form while simultaneously locking the rings in the closed-loop configuration to prevent inadvertent opening. | 07-17-2014 |
Patent application number | Description | Published |
20100294138 | VERSATILE COOKING DEVICE - Disclosed are accessories for use on the cooking grate of a barbeque grill or such, which are adapted to enable the effective grilling of such food items as fish, pizza, small items, and delicate items, alone of in combination, and which overcome drawbacks of grilling such food items while allowing the food items to receive the flavor benefits of grilling. | 11-25-2010 |
20110223296 | SANDWICH COOKING ACCESSORY - Disclosed is a sandwich cooking accessory having a plurality of pockets in which may be assembled a sandwich or into which may be placed a raw (not yet cooked) sandwich. The accessory also includes a panel engagable to the pockets to contain the assembled sandwiches during handling and cooking. The panel cooperates with the pockets to slightly, but not excessively, compress the sandwiches. The pockets and panel are perforated to enable heat to the sandwiches during cooking. The panel include a plurality of shield to protect certain portions of the sandwiches from excessive toasting during cooking. | 09-15-2011 |
20120160823 | HEATING APPARATUS - Several embodiments of an electric heater are disclosed, each of which includes a master or a satellite heating unit and a slave or a base heating unit. The base or slave unit selectably derives heating power and heating control either from the master or satellite unit through a disconnectable electrical cord or derives heating power and heating control independently there-from. The master or satellite and slave or base units are adapted for tool-free mechanical attachment and separation. A communicating arrangement distinguishes between the attachment and the separation and alters the heating power and control according thereto by causing transfer of at least some of the heating control of the slave or base unit from the slave or base unit to the master or satellite unit during the attachment. | 06-28-2012 |
Patent application number | Description | Published |
20100200074 | Fluid Control Platform and System - A fluid control platform that may control various fluid control components and is scalable by connecting with additional substantially identical platforms, as well as related systems, methods of manufacturing the same, and methods of fluid control are disclosed. the platform may include a programmable controller, a power supply, a data input, a data output device, and/or a networking connection, among other things. A coordinated fluid control system may include multiple networked platforms, which may be networked to each other in, for example, a ring. The programmable controller may be provided with hardware that permits operation of each of a plurality of fluid control components, some of which may be intelligent fluid control components. | 08-12-2010 |
20120136490 | FLUID CONTROL SYSTEM - A fluid control platform that may control various fluid control components and is scalable by connecting with additional substantially identical platforms, as well as related systems, methods of manufacturing the same, and methods of fluid control are disclosed. the platform may include a programmable controller, a power supply, a data input, a data output device, and/or a networking connection, among other things. A coordinated fluid control system may include multiple networked platforms, which may be networked to each other in, for example, a ring. The programmable controller may be provided with hardware that permits operation of each of a plurality of fluid control components, some of which may be intelligent fluid control components. | 05-31-2012 |