Wilson, PA
Alan Wilson, Wexford, PA US
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20130082180 | Multipoint Method for Assessing a Biological Sample - A system and method for multipoint assessment of a biological sample, which may comprise a bodily fluid. The sample is irradiated to generate a plurality of interacted photons. These photons are assessed to evaluate a component of the sample. The component may comprise at least one of: a protein, a flavonoid, a keratinoid, a metabolite, an electrolyte, an enzyme, and combinations thereof. The component may also comprise at least one of: a chemical agent, a biological toxin, a microorganism, a bacterium, a protozoan, a virus, and combinations thereof. The evaluation may comprise determining at least one of: a disease state, a disease stage, a metabolic state, a hydration state, an inflammatory state, and combinations thereof. | 04-04-2013 |
Alan Wilson, Moon Township, PA US
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20140093147 | System and method for gross anatomic pathology using hyperspectral imaging - A method for analyzing organ samples using hyperspectral imaging comprising illuminating an organ sample to generate interacted photons, collecting the interacted photons and passing the interacted photons through a tunable filter. The filtered interacted photons are detected to generate a hyperspectral image. A brightfield image is generated and associated with the hyperspectral image. Spectra from locations of interest are extracted and analyzed to assess a characteristic of the organ sample. A system may comprise an illumination source to illuminate an organ sample and generate interacted photons, a collection optics for collecting the interacted photons and a tunable filter to filter the interacted photons. A detector is configured to detect the filtered photons and generate at least one hyperspectral image. The detector may also be configured to generate at least one brightfield image representative of the organ sample. | 04-03-2014 |
20150294076 | SYSTEM AND METHOD FOR SERUM BASED CANCER DETECTION - A system and method for analyzing biological samples, such as dried human blood serum, to determine a disease state such as colorectal cancer (CRC). Using dried samples may hold potential for enhancing localized concentration and/or segmentation of sample components. The method may comprise illuminating at least one location of a biological sample to generate a plurality of interacted photons, collecting the interacted photons and generating at least one Raman data set representative of the biological sample. A system may comprise an illumination source to illuminate at least one location of a biological sample and generate at least one plurality of interacted photons, at least one mirror for directing the interacted photons to a detector. The detector may be configured to generate at least one Raman data set representative of the biological sample. The system and method may utilize a FAST device for multipoint analysis or may be configured to analyze a sample using a line scanning configuration. | 10-15-2015 |
Alexander F Wilson, Wayne, PA US
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20160135532 | MULTIFUNCTIONAL HAT ASSEMBLY - A novel assembly for a hat comprised of removably coupled socks, fabric panels, gloves, and/or mittens. The present disclosure relates generally to a hat comprised of fully intact, yet selectively removable, socks, fabric panels, gloves, and/or mittens that are connected together by various disclosed methods. The socks, fabric panels, gloves, and/or mittens may be comprised of a variety of materials and styles, and can be coupled together through a number of disclosed combinations to form a winter hat that can be converted to one or more pairs of socks, fabric panels, gloves, and/or mittens. | 05-19-2016 |
Alexander S. Wilson, Kenneth Square, PA US
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20140244480 | SYSTEMS AND METHODS FOR PROVIDING A USER INTERFACE FOR FACILITATING PERSONAL PAYMENT TRANSACTIONS - Systems and processes are disclosed for providing customized user interfaces for facilitating personal payment transactions. In certain embodiments, disclosed embodiments may generate a dynamic and customized interface for effecting the personal payment transaction by, for example, providing one or more options for the payer to fund the payment. The disclosed embodiments may provide an interface that includes one or more suggested recipients for identifying the payee associated with the payment transaction. The disclosed embodiments may also provide an interface that includes one or more routing options to route the payment. The disclosed embodiments may also provide an interface that provides one or more communication channel options for parties associated with the personal payment transaction to communicate. | 08-28-2014 |
Alexander S. Wilson, Kennett Square, PA US
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20140172693 | SYSTEMS AND METHODS FOR EFFECTING APPLICATION PROGRAMMING INTERFACES FOR PERSONAL PAYMENT TRANSACTIONS - Systems, processes, and computer programs are disclosed for facilitating personal payment transactions. In some embodiments, disclosed embodiments may provide an interface dialog engine for providing a dynamic and customized interface for effecting the personal payment transaction; a funding source engine for providing options to fund the payment; an payee identity engine for identifying the intended payee receiving the payment; a routing option engine for providing options to route the payment; and a messaging engine for providing channels for related parties to the personal payment transaction to communicate. | 06-19-2014 |
20140172694 | SYSTEMS AND METHODS FOR EFFECTING PERSONAL PAYMENT TRANSACTIONS - Systems, processes, and computer programs are disclosed for facilitating personal payment transactions. In certain embodiments, disclosed embodiments may provide an interface dialog engine for providing a dynamic and customized interface for effecting the personal payment transaction and a funding source engine for providing options to fund the payment. The disclosed embodiments may also provide a payee identity engine for identifying the intended payee receiving the payment and a routing option engine for providing options to route the payment. The embodiments may also provide a messaging engine for providing channels for related parties to the personal payment transaction to communicate. | 06-19-2014 |
20140172695 | SYSTEMS AND METHODS FOR PROVIDING A USER INTERFACE FOR FACILITATING PERSONAL PAYMENT TRANSACTIONS - Systems and processes are disclosed for providing customized user interfaces for facilitating personal payment transactions. In certain embodiments, disclosed embodiments may generate a dynamic and customized interface for effecting the personal payment transaction by, for example, providing one or more options for the payer to fund the payment. The disclosed embodiments may provide an interface that includes one or more suggested recipients for identifying the payee associated with the payment transaction. The disclosed embodiments may also provide an interface that includes one or more routing options to route the payment. The disclosed embodiments may also provide an interface that provides one or more communication channel options for parties associated with the personal payment transaction to communicate. | 06-19-2014 |
Andre Wilson, Delmont, PA US
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20100183474 | ALUMINUM-COPPER ALLOYS CONTAINING VANADIUM - New 2xxx aluminum alloys containing vanadium are disclosed. In one embodiment, the aluminum alloy includes 3.3-4.1 wt. % Cu, 0.7-1.3 wt. % Mg, 0.01-0.16 wt. % V, 0.05-0.6 wt. % Mn, 0.01 to 0.4 wt. % of at least one grain structure control element, the balance being aluminum, incidental elements and impurities. The new alloys may realize an improved combination of properties, such as in the T39 or T89 tempers. | 07-22-2010 |
20140137995 | ALUMINUM-COPPER ALLOYS CONTAINING VANADIUM - New 2xxx aluminum alloys containing vanadium are disclosed. In one embodiment, the aluminum alloy includes 3.3-4.1 wt. % Cu, 0.7-1.3 wt. % Mg, 0.01-0.16 wt. % V, 0.05-0.6 wt. % Mn, 0.01 to 0.4 wt. % of at least one grain structure control element, the balance being aluminum, incidental elements and impurities. The new alloys may realize an improved combination of properties, such as in the T39 or T89 tempers. | 05-22-2014 |
20140248176 | ALUMINUM-COPPER ALLOYS CONTAINING VANADIUM - New 2xxx aluminum alloys containing vanadium are disclosed. In one embodiment, the aluminum alloy includes 3.3-4.1 wt. % Cu, 0.7-1.3 wt. % Mg, 0.01-0.16 wt. % V, 0.05-0.6 wt. % Mn, 0.01 to 0.4 wt. % of at least one grain structure control element, the balance being aluminum, incidental elements and impurities. The new alloys may realize an improved combination of properties, such as in the T39 or T89 tempers. | 09-04-2014 |
Christina A. Wilson, Lansdowne, PA US
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20100068308 | Regulation of GSK-3alpha activity for the treatment or prevention of Alzheimer's disease - Provided is a novel use of therapeutic concentrations of an inhibitor of glycogen synthase kinase-3 (GSK-3), including lithium or any other GSK-3 inhibitor, to block, reduce or inhibit processing of amyloid precursor proteins to beta-amyloid (Aβ) peptides, which are now believed to be the principal cause of Alzheimer's disease, thereby providing methods useful for the prevention, inhibition or reversal of the disease. Also provided are methods of using agents that specifically target the α isoform of GSK-3, which is responsible for APP processing, making such selective GSK-3α-specific inhibitors especially useful in the treatment, prevention, and possible reversal of Alzheimer's disease. Further provided are kits and screening methods associated with the present methods. | 03-18-2010 |
Christopher Roi Wilson, Fairless Hills, PA US
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20150268124 | TEST HEAD ASSEMBLY FOR USE IN TESTING PROTECTIVE MASKS - An apparatus for use in testing protective masks for leaks. The apparatus includes a test head assembly for supporting at least a portion of a protective mask to be tested for leaks. The test head assembly may be freestanding, mounted directly on a mask tester or integral with the mask tester. The test head assembly includes a body and a cover. The body includes a head section simulating at least a portion of a human head. The cover is mounted on the body to cover at least a portion of the head section. The test head assembly is preferably configured such that a portion of the cover can be inflated while the remaining portion of the cover remains in a relaxed state and in contact with the corresponding portion of the body. | 09-24-2015 |
Craig Wilson, Allison Park, PA US
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20130289272 | METHODS FOR PRODUCING 1,5,7-TRIAZABICYCLO[4.4.0]DEC-5-ENE BY REACTION OF A DISUBSTITUTED CARBODIIMIDE AND DIPROPYLENE TRIAMINE - Methods for producing 1,5,7-triazabicyclo[4.4.0]dec-5-ene using a disubstituted carbodiimide, dipropylene triamine and optionally an ethereal solvent and/or an alcohol are disclosed. Use of 1,5,7-triazabicyclo[4.4.0]dec-5-ene produced by this method in an electrodepositable coating composition, and electrophoretic deposition of such coating onto a substrate to form a coated substrate, are also disclosed. | 10-31-2013 |
20140014524 | ELECTRODEPOSITABLE COATING COMPOSITIONS EXHIBITING RESISTANCE TO CRATERING - The present invention relates to electrodepositable coating compositions that produce cured coatings that exhibit resistance to cratering. The coating compositions include an active hydrogen-containing cationic salt group-containing polymer; and 0.1 to 20 percent by weight, based on the total weight of resin solids in the coating composition, of an ungelled acrylic polymer. | 01-16-2014 |
20140131212 | ELECTRODEPOSITABLE COATING COMPOSITIONS CONTAINING DIMETHYL CATALYST - An electrodepositable composition comprising; | 05-15-2014 |
20140131213 | ELECTRODEPOSITABLE COATING COMPOSITIONS CONTAINING DIALKYLTIN CATALYST - An electrodepositable composition comprising: | 05-15-2014 |
20150122663 | ELECTRODEPOSITABLE COATING COMPOSITIONS EXHIBITING RESISTANCE TO CRATERING - The present invention relates to electrodepositable coating compositions that produce cured coatings that exhibit resistance to cratering. The coating compositions include an active hydrogen-containing cationic salt group-containing polymer; and 0.1 to 20 percent by weight, based on the total weight of resin solids in the coating composition, of an ungelled acrylic polymer. | 05-07-2015 |
20150267856 | METHOD FOR COATING PIPE SEGMENTS - A method for coating a segment of pipe is disclosed. The method comprises applying by electrodeposition a coating composition to the segment of pipe wherein the coating composition comprises: | 09-24-2015 |
20150307722 | METHODS FOR PRODUCING 1,5,7-TRIAZABICYCLO[4.4.0]DEC-5-ENE BY REACTION OF A DISUBSTITUTED CARBODIIMIDE AND DIPROPYLENE TRIAMINE - Methods for producing 1,5,7-triazabicyclo[4.4.0]dec-5-ene using a disubstituted carbodiimide, dipropylene triamine and optionally an ethereal solvent and/or an alcohol are disclosed. Use of 1,5,7-triazabicyclo[4.4.0]dec-5-ene produced by this method in an electrodepositable coating composition, and electrophoretic deposition of such coating onto a substrate to form a coated substrate, are also disclosed. | 10-29-2015 |
Craig A. Wilson, Allison Park, PA US
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20090045065 | STABILIZING AQUEOUS ANIONIC RESINOUS DISPERSIONS WITH CHELATING AGENTS - Stabilization of aqueous resinous dispersions containing a pigment of a divalent metal such as strontium chromate is disclosed. Stabilization is achieved by incorporating a chelating agent in the dispersion. | 02-19-2009 |
20090045071 | ELECTRODEPOSITION COATINGS FOR USE OVER ALUMINUM SUBSTRATES - A process for applying a coating on aluminum substrates by anionic electrodeposition of a phosphated epoxy resin made by phosphating a polyepoxide with both phosphoric acid and an organophosphonic acid and/or an organophosphinic acid. The coating has a reduced tendency to form pinholes. | 02-19-2009 |
20090236231 | ELECTRODEPOSITION OF DIELECTRIC COATINGS ON SEMICONDUCTIVE SUBSTRATES - A method includes: immersing a semiconductive substrate in an electrodeposition composition, wherein at least 20 percent by weight of resin solids in the composition is a highly cross-linked microgel component, and applying a voltage between the substrate and the composition to form a dielectric coating on the substrate. A composition for use in electrodeposition includes a resin blend, a coalescing solvent, a catalyst, water, and a highly cross-linked migrogel, wherein at least 20 percent by weight of resin solids in the composition is the highly cross-linked microgel. Another composition for use in electrodeposition includes a surfactant blend, a low ion polyol, phenoxypropanol, a catalyst, water, a flexibilizer, and a highly cross-linked migrogel, wherein at least 20 percent by weight of resin solids in the composition is the highly cross-linked microgel. | 09-24-2009 |
20100243108 | METHOD FOR TREATING AND/OR COATING A SUBSTRATE WITH NON-CHROME MATERIALS - The present invention is directed to a method for coating a substrate comprising: (a) applying a caustic cleaner onto at least a portion of the substrate; (b) rinsing at least a portion of the substrate that was subjected to step (a) with water; (c) applying an acid cleaner onto at least a portion of the caustically cleaned substrate; (d) rinsing at least a portion of the substrate that was subjected to step (c) with water; and (e) applying a conversion coating comprising zirconium onto at least a portion of the acid cleaned substrate; and wherein at least one of the materials used in steps (c) and (e) is substantially chrome free. The present invention is also directed to a substrate, such as an aluminum substrate, that has been coated using the aforementioned method. | 09-30-2010 |
20120006683 | ELECTRODEPOSITION OF DIELECTRIC COATINGS ON SEMICONDUCTIVE SUBSTRATES - A composition for use in electrodeposition includes a resin blend, a coalescing solvent, a catalyst, water, and a highly cross-linked migrogel, wherein at least 20 percent by weight of resin solids in the composition is the highly cross-linked microgel. Another composition for use in electrodeposition includes a surfactant blend, a low ion polyol, phenoxypropanol, a catalyst, water, a flexibilizer, and a highly cross-linked migrogel, wherein at least 20 percent by weight of resin solids in the composition is the highly cross-linked microgel. | 01-12-2012 |
20130289273 | METHODS FOR PRODUCING 1,5,7-TRIAZABICYCLO[4.4.0]DEC-5-ENE BY REACTION OF A DISUBSTITUTED CARBODIIMIDE AND DIPROPYLENE TRIAMINE - Methods for producing 1,5,7-triazabicyclo[4.4.0]dec-5-ene using a disubstituted carbodiimide, dipropylene triamine and optionally an ethereal solvent and/or an alcohol are disclosed. Use of 1,5,7-triazabicyclo[4.4.0]dec-5-ene produced by this method in an electrodepositable coating composition, and electrophoretic deposition of such coating onto a substrate to form a coated substrate, are also disclosed. | 10-31-2013 |
20140255702 | ELECTRODEPOSITABLE FILM-FORMING COMPOSITIONS CAPABLE OF FORMING STRATIFIED FILMS, AND THEIR USE IN COMPACT PROCESSES - An electrodepositable film-forming composition is provided, comprising a resinous phase dispersed in an aqueous medium. The resinous phase comprises: (1) an ungelled active hydrogen-containing, cationic resin derived from a polyepoxide; (2) a cationic acrylic resin containing urethane functional groups; and (3) an at least partially blocked polyisocyanate curing agent. Also provided is a coated metal substrate comprising: A) a metal substrate having at least one coatable surface, and B) a cured coating layer deposited on at least one surface of the substrate and having a coating/air interface and a coating/substrate interface, wherein the cured coating layer is deposited from the electrodepositable film-forming composition described above. Further provided is a process for coating an electroconductive substrate, comprising electrophoretically depositing on the substrate the curable, electrodepositable coating composition described above. | 09-11-2014 |
20140262786 | PHENOLIC ADMIX FOR ELECTRODEPOSITABLE COATING COMPOSITION CONTAINING A CYCLIC GUANIDINE - The present invention is directed to an electrodepositable coating composition comprising a reaction product of an epoxy functional polymer and a cyclic guanidine, and a source of unreacted phenol, wherein the electrodepositable coating composition has a columbic usage of less than 100 coulombs/gram when deposited on a conductive substrate at a current density of ≦1.5 mAmps/cm | 09-18-2014 |
Daniel H. Wilson, Pittsburgh, PA US
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20100057445 | System And Method For Automatically Adjusting Floor Controls For A Conversation - A system and method for automatically adjusting floor controls for a conversation is provided. Audio streams are received, which each originate from an audio source. Floor controls for a current configuration including at least a portion of the audio streams are maintained. Conversational characteristics shared by two or more of the audio sources are determined. Possible configurations for the audio streams are identified based on the conversational characteristics. An analysis of the current configuration and the possible configurations is performed. A change threshold is applied to the analysis. When the analysis satisfies the change threshold, the floor controls are automatically adjusted. The audio streams are mixed into one or more outputs based on the adjusted floor controls. | 03-04-2010 |
20120158402 | System And Method For Adjusting Floor Controls Based On Conversational Characteristics Of Participants - A system and method for automatically adjusting floor controls based on conversational characteristics is provided. Audio streams are received, which each originate from an audio source. Floor controls for a current configuration including at least a portion of the audio streams are maintained. Conversational characteristics shared by two or more of the audio sources are determined. Possible configurations for the audio streams are identified based on the conversational characteristics. An analysis of the current configuration and the possible configurations is performed. A change threshold comprising a minimum number of timeslices for at least one of the current configuration and one of the possible configurations is applied to the analysis. When the analysis satisfies the change threshold, the floor controls are automatically adjusted. The audio streams are mixed into one or more outputs based on the adjusted floor controls. | 06-21-2012 |
David C. Wilson, Monroeville, PA US
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20110274698 | Immunomodulation Of Inflammatory Conditions Utilizing Follistatin-Like Protein-1 And Agents That Bind Thereto - Follistatin-like protein (FSTL-1) is a secreted glycoprotein of unknown function, first isolated from mouse osteoblastic cells as a transforming growth factor-β1-inducible gene. The inventors have discovered that FSTL-1 is a proinflammatory mediator. As such, the invention provides for composition and methods of using agents that bind to FSTL-1 to modulate various types of inflammation (e.g., autoimmune diseases). Inhibitors and antagonists of FSTL-1, particularly antibodies or antibody fragments, may be used to treat conditions related to inflammation, such as arthritis. In addition, the inventors have discovered that FSTL-1 has a role in the Th17 pathway. Accordingly, the invention provides for compositions and methods of using agents which bind to FSTL-1 to modulate the generation of Th17 cells. Such agents are useful for delaying development of and treating diseases associated with undesired production of Th17 cells, such as autoimmune diseases. Furthermore, since FSTL-1 is a proinflammatory mediator with a role in cancer, the invention provides for compositions and methods of using a pharmaceutical composition of FSTL-1 to delay development of or treat cancer. | 11-10-2011 |
20130149712 | FOLLISTATIN-LIKE PROTEIN-1 AS A BIOMARKER FOR INFLAMMATORY DISORDERS - The present invention relates to methods and compositions for diagnosis of inflammatory disorders, and in non-limiting embodiments, of inflammatory disorders associated with elevated interleukin-1β (“IL-1β”), based on increased levels of follistatin-like protein 1 (“FSTL-1”). In particular non-limiting embodiments, the invention further provides for methods of identifying subjects with systemic onset juvenile idiopathic arthritis (“SOJIA”) who are at increased risk for developing macrophage activation syndrome (“MAS”) comprising detecting, in said subjects, hyper-increased levels of FSTL-1. In additional non-limiting embodiments, the invention provides for methods of identifying subjects with Kawasaki disease who are at increased risk of developing aortic aneurysms comprising detecting, in said subjects, hyper-increased levels of FSTL-1. | 06-13-2013 |
20150376594 | STABILIZATION OF BIOMOLECULES BY ATTACHMENT OF RESPONSIVE POLYMERS AND SENSORS THEREOF - The present invention provides a biomolecule conjugate having one or more functionalized biomolecules wherein the biomolecule is functionalized with one or more reactive sites, and at least one polymer capable of undergoing a polymer growth reaction, wherein the polymer is attached to at least one of the reactive sites of the functionalized biomolecule and wherein the polymer envelopes the functionalized biomolecule to form a reversible nanoparticle structure which protects the biomolecule by dynamically collapsing to preserve the biomolecule when an adverse environmental stimulus is present. A method of protecting a biomolecule from environmental conditions is also provided. | 12-31-2015 |
David F. Wilson, Philadelphia, PA US
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20090082650 | IMAGING OF OXYGEN BY PHOSPHORESCENCE QUENCHING - A method of real-time imaging of dissolved oxygen concentration, comprising adding an oxygen-quenched phosphorescent composition to a sample, exciting phosphorescence in the composition by illuminating the sample with pulses of light, detecting phosphorescence intensity as a function of position in the sample at first and second times following exciting pulses of light, determining oxygen concentration from the phosphorescence detected at the first and second times, generating an image of the oxygen concentration as a function of position, and repeating the exciting, detecting, determining, and image generating steps to produce a series of images showing the oxygen concentration varying over time. | 03-26-2009 |
20090216097 | Oxygen Sensor for Internal Monitoring of Tissue Oxygen in Vivo - Provided is a durable oxygen sensitive probe of sufficient strength to withstand direct tissue pressures in vivo, the probe comprising a sensor chamber within a biocompatible, gas-permeable membrane containing an oxygen sensitive analyte solution producing oxygen quenchable phosphorescence when excited. Further provided is a tissue oxygen detection and measurement system comprising the probe, and methods for use of the probe and the system to directly, rapidly and accurately measure tissue oxygen levels in a patient without reliance on blood vessels or fluid protection of the probe. | 08-27-2009 |
20090280522 | Method For Rapid Detection And Evaluation Of Cultured Cell Growth - Provided is a method and system for the rapid and accurate detection of growth and metabolism of a cellular microorganism in a population of microorganisms in a non-liquid, culture medium. Further provided is a gelled culture medium containing a non-toxic, water-soluble, phosphorescent compound which measures oxygen content (partial pressure) of a microorganism also contained therein, by oxygen-dependent quenching of phosphorescence; or the gel contains a fluorescent pH indicator that demonstrates growth of the microorganism by pH-dependent intensity change or wavelength shift in the emission spectrum. Further provided is a system and method for killing undesirable microorganisms or colonies in the culture medium without harming the surrounding microorganisms. | 11-12-2009 |
20110105869 | Sensor for Internal Monitoring of Tissue O2 and/or pH/CO2 In Vivo - Provided is a durable tissue pH/pCO | 05-05-2011 |
20120058919 | Method For Rapid Detection And Evaluation Of Cultured Cell Growth - Provided is a method and growth chamber for the rapid and accurate detection of growth and metabolism of a cellular microorganism in isolation within one or a plurality of wells containing a population of microorganisms in a non-liquid, culture medium, wherein the cells are distributed at not greater than one cell per well at plating. Further provided is a gelled culture medium containing a non-toxic, water-soluble, phosphorescent compound which measures oxygen content (partial oxygen pressure) of a microorganism also contained therein, by oxygen-dependent quenching of phosphorescence; or the gel contains a fluorescent pH indicator that demonstrates growth of the microorganism by pH-dependent intensity change or wavelength shift in the emission spectrum. | 03-08-2012 |
20130224874 | Phosphorescent Molecules for Measuring Oxygen and Imaging Methods - Oxygen levels in biological tissue or systems can be measured by the phosphorescence quenching method using phosphorescent porphyrin probes, also referred to as a dendritic oxygen probes, with controllable quenching parameters and defined biodistributions. Provided are a “next generation” of oxygen sensors with substantially improved phosphorescence emission for better imaging capabilities, ease of use, increasing the quantum efficiency (phosphorescence intensity) and extending their range of applicability including constructing a class of oxygen sensors for making measurements in organic media. In addition, provided are methods for synthesizing new porphyrin constructs in which the porphyrin is made less flexible and more planar, changing with decrease internal quenching, and thereby increasing the phosphorescence emission used for oxygen sensing. Additional methods are provided for structurally modifying the dendrimer used to encapsulate the porphyrin phosphor to provide internal quenching of singlet oxygen molecules formed during oxygen measurements. | 08-29-2013 |
David S. Wilson, Frazer, PA US
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20150313965 | Combination of Lenalidomide and Polypeptide Construct, and Uses Thereof - Methods for cancer treatment include administering to a cancer patient an anti-CD38 antibody-attenuated human IFN alpha-2b construct and lenalidomide or pomalidomide. Tumors that may be treated according to these methods include tumors which comprise CD-38 expressing tumor cells, including B-cell lymphoma, multiple myeloma, non-Hodgkin's lymphoma, chronic myelogenous leukemia, chronic lymphocytic leukemia, and acute lymphocytic leukemia. | 11-05-2015 |
David T. Wilson, Jacobus, PA US
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20110300741 | PHOTOVOLTAIC MODULE CONNECTOR ASSEMBLIES HAVING CABLE STRAIN RELIEF - An electrical connector assembly including a connector housing having a plurality of sides that define an inner region of the connector housing and include opposite loading and mating sides. The connector housing has a cable channel located in the inner region that extends between the loading and mating sides and a slot oriented substantially transverse to the cable channel. The slot extends through the cable channel. The connector assembly also includes a conductive cable that is received in the cable channel and extends along a central cable axis. The conductive cable has an outer surface and is configured to electrically engage the PV module. The connector assembly also includes a retaining member that is inserted into the slot. The retaining member surrounds the conductive cable about the cable axis and grips the outer surface of the conductive cable. | 12-08-2011 |
D. Bruce Wilson, Spring City, PA US
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20110031702 | POLYIMIDE RESIN GASKETS FOR DISS OUTLET VALVES - Gaskets made of a polyimide resin material for use in DISS valve connections are disclosed. Polyimide resin gaskets are relatively low cost and can be used in all types of operations requiring DISS connections. Polyimide gaskets exhibit negligible creep and can be used for long periods of time without significant deterioration of the leak rate. | 02-10-2011 |
Douglas A. Wilson, Wampum, PA US
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20130255591 | Multiple Sequential Shot Dog Training Apparatus - A portable device for launching a plurality of retriever dummies is described. The device is light-weight, portable, can be remotely triggered, and requires only a single person to operate. The device has a plurality of legs secured to a main beam and at least one strut extending from the main beam. The legs are preferably articulated and can function as struts. Elastomeric bands extend from a basket to the strut, through a pulley, and back to an anchor. The bands are stretched so that the basket can be fastened to a release mechanism. A retriever object can be placed in the basket. An operator can distance himself from the device and, using a remote control, disengage the fastener from the release mechanism so that the object is launched. The release mechanism is capable of retaining an elastomeric band under high tension while permitting its release using a low voltage electric motor. | 10-03-2013 |
20150121739 | SHOTGUN SIMULATOR - A shotgun sound simulator comprises an donated enclosed tube defining a combustion chamber into which an ignitable mixture can be combusted. The tube also includes at least one baffle and an open end having a smaller diameter than the tube. The open end permits ignited gases to escape. By controlling the ratios of the tube diameter (TI), the outlet port diameter (OP), baffle opening diameter (BH), combustion chamber length (CC); and the distance from the combustion chamber to the outlet port (RC), a simulated shotgun sound can be produced upon combustion of a gas in the combustion chamber. Conveniently, the outlet port can be made to receive a training bumper that is launched when the gas is ignited. | 05-07-2015 |
Frank Wilson, West Chester, PA US
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20130150851 | MONOFIX NAIL - An intramedullary device includes an intramedullary nail extending along a longitudinal axis from a proximal end to a distal end, the nail including a channel extending longitudinally therethrough and an opening extending laterally through a wall thereof proximate the distal end, the channel including a ramped surface along a distal portion thereof opposite the opening. The device further includes a wire extending along a longitudinal axis from a proximal end to a distal end, the wire sized and shaped to be inserted into the channel of the nail such that the distal end engages the ramped surface to extend through the opening. | 06-13-2013 |
20150173843 | TRACKING MEDICAL DEVICES - Techniques for tracking medical devices, for instance medical implants, are described herein. Medical devices can be tracked that are, for example, not directly marked with an identifier. In one embodiment, a device tracking application can execute on a computer system. Such a computer system can include one more computing devices that can optionally communicate with each other to send and receive information associated with medical devices. In accordance with one embodiment, a storage object image representative of a storage object is displayed on a display of a computer system. The storage object image can include a plurality of storage location areas that represent a plurality of storage locations within the storage object. Devices can be tracked based on the storage location areas of the storage object image. | 06-25-2015 |
Frank Andrew Wilson, West Chester, PA US
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20120247284 | INTERLOCK DRIVING INSTRUMENT - An interlock driving instrument is configured to be releasably lockable to a fastener, such as a bone anchor. A bone anchor can be locked to the interlock driving instrument by inserting an expandable distal end of the shaft of the interlock driving instrument into the driving opening of the bone anchor and expanding the distal end within the driving opening by translating an expansion member into the expandable distal end. Alternatively, the bone anchor can be locked to the interlock driving instrument by inserting the distal end of the shaft of the interlock driving instrument into the driving opening of the bone anchor and translating a sliding member along a sloped surface defined in a channel extending into the shaft. | 10-04-2012 |
20120253355 | INTERLOCK DRIVING INSTRUMENT - An interlock driving instrument is configured to be releasably lockable to a fastener, such as a bone anchor. A bone anchor can be locked to the interlock driving instrument by inserting an expandable distal end of the shaft of the interlock driving instrument into the driving opening of the bone anchor and expanding the distal end within the driving opening by translating an expansion member into the expandable distal end. Alternatively, the bone anchor can be locked to the interlock driving instrument by inserting the distal end of the shaft of the interlock driving instrument into the driving opening of the bone anchor and translating a sliding member along a sloped surface defined in a channel extending into the shaft. | 10-04-2012 |
Geoffrey R. Wilson, Kittanning, PA US
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20130032511 | APPARATUS AND PROCESSES FOR PRODUCTION OF COAL DERIVED OIL PRODUCTS - Apparatus and processes for production of coal derived oils from a mixture of pulverized coal and a coal solvent in predetermined proportions, which when agitated produces a substantially ash-free coal slurry liquid. Subsequently the coal slurry liquid is heat treated in a fractionator to produce predetermined products, and a portion of the resultant coal solvent is recovered and recycled to produce coal derived oils. | 02-07-2013 |
George Wilson, Pittsburgh, PA US
Patent application number | Description | Published |
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20130186344 | Cat collection box - A cat litter box having a side wall defining an interior and a bottom surface within the interior formed from a main door and multiple secondary doors which form on opening. Each door includes a slat connected below the slatted edge on an underside thereof traveling most of a length of the slatted edge, and the doors are hingedly attached to the side wall of the housing. Provided is a means for manipulating the main door upwards and downwards such that the main free edge can be pushed against the slat of an adjacent one of the secondary doors to provide a downward force against each the secondary door to reveal the opening. In this manner, any contained soiled litter can periodically be dumped and the contents removed, resulting in an easy-to-use, sanitary cat litter box system. | 07-25-2013 |
Gregory S. Wilson, Oil City, PA US
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20110115277 | METHOD FOR STEERING A MINING MACHINE CUTTER - A control system monitors the angle of each ranging arm, with respect to the mainframe of the machine. While the machine is in a defined zone along the face, if the angle of the arm is detected to be lower than a parameter defined set-point called the undercut limit, the control system does not allow the arm to be lowered further. When entering the run of face from either gate end, if either of the ranging arms are below the set point, the horizontal movement of the shearer is stopped, and an alarm message is generated, and a warning light begins to flash, alerting the operator that he must raise the arm before horizontal movement of the shearer can be enabled. | 05-19-2011 |
Harold J. Wilson, Center Valley, PA US
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20100034247 | Methods And Appratus For Evaluating A Utilization Of A System That Provides Connections Using A Normalized Bandwidth Scheme - Methods and apparatus are provided for evaluating the throughput limit of a communication system, such as a network node or system. A throughput limit of a communication system is evaluated by receiving a request to allocate at least one connection of a given data type; obtaining an assigned weight for the at least one connection, wherein the assigned weight is based on the throughput limit and a processing limit indicating a throughput of the communication system for the given data type within a given time window; and determining whether to allocate the at least one connection of a given data type based on whether a sum of the assigned weights for each existing allocated connection for each data type exceeds the throughput limit. The assigned weight for a given data type can be subtracted from the sum upon receiving a request to de-allocate a connection. | 02-11-2010 |
Jame M. Wilson, Gladwyne, PA US
Patent application number | Description | Published |
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20110008295 | SIMIAN ADENOVIRUSES SADV-36, -42.1, -42.2, AND -44 AND USES THEREOF - A recombinant vector comprises simian adenovirus 36, simian adenovirus 42.1, simian adenovirus 42.2 and/or simian adenovirus 44 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus-36, -42.1, -42.2 or -44 gene(s) is also described. Methods of using the vectors and cell lines are provided. | 01-13-2011 |
James Wilson, Franklin, PA US
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20140257722 | PREDICTING MOTOR FAILURE BASED ON RELATIONSHIP OF MOTOR PAIR CHARACTERISTICS - A system and method of predicting motor failure based on relationships of motor pair characteristics, such as temperatures. A motor pair detection module receives temperatures for each motor of a motor pair over a predetermined window. The motor pair detection module determines whether at least one of the temperatures of the first motor and the second motor exceeds a temperature threshold during the predetermined time window. The motor pair detection module further determines whether the temperature of the first motor differed from the temperature of the second motor by at least a difference threshold for at least a percentage threshold of the predetermined time window. Based on the determinations, the motor pair temperature outputs an alarm signal to indicate a potential impending failure of one of the motors of the motor pair. | 09-11-2014 |
James A. Wilson, Lancaster, PA US
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20140303451 | Health Monitoring Apparatus - A health monitoring apparatus is providing, which includes a body section and a housing section that covers the body section. The body section includes a printed circuit board, a flow meter section, a first mouth probe, a second mouth probe, and a non-contact thermometer light guide. The flow meter section includes a base and a pair of channel walls extending upward from the base and a gap there between to define a fluid flow channel having a fluid receiving passageway. The first mouth probe extends outward from the fluid flow channel, and the second mouth probe is disposed axially with respect to the first mouth probe and extends outward from the fluid flow channel. The non-contact thermometer light guide is disposed along the first mouth probe and leads into the flow meter section. The non-contact thermometer light guide includes an electromagnetic radiation sensor disposed along a trailing end of the non-contact thermometer light guide. | 10-09-2014 |
James J. Wilson, Nazareth, PA US
Patent application number | Description | Published |
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20100294438 | ROMAN SHADE SYSTEM - A shade system comprises a shade fabric, such as a roman shade fabric, a roller tube, at least one wide flexible lift band (i.e., a section of flexible material) windingly received around the roller tube and extending from the roller tube to a bottom end the of the shade fabric, and a plurality of coupling structures for holding the flexible material adjacent to a rear surface of the shade fabric. Each coupling structure is attached to the rear surface of the shade fabric at attachment points that are spaced apart, such that the coupling structures and the shade fabric form openings for slidingly receiving the lift band. The lift band is coupled to the bottom end of the shade fabric, such that bottom end of the shade fabric moves up and down as the roller tube is rotated in respective directions, so as to raise and lower the shade fabric. | 11-25-2010 |
20120255689 | BATTERY-POWERED MOTORIZED WINDOW TREATMENT HAVING A SERVICE POSITION - A battery-powered motorized window treatment for covering at least a portion of a window may be adjusted into a service position to allow for access to at least one battery that is powering the motorized window treatment. A headrail of the motorized window treatment may be adjusted to the service position to allow for easy replacement of the batteries without unmounting the headrail and without requiring tools. The motorized window treatment may comprise brackets having buttons that may be actuated to release the headrail from a locked position, such that the head rail may be rotated into the service position. The headrail easily rotates through a controlled movement into the service position, such that a user only needs one free hand available to move the motorized window treatment into the service position and change the batteries. | 10-11-2012 |
20130153162 | BATTERY-POWERED MOTORIZED WINDOW TREATMENT HAVING A SERVICE POSITION - A battery-powered motorized window treatment for covering at least a portion of a window may be adjusted into a service position to allow for access to at least one battery that is powering the motorized window treatment. A headrail of the motorized window treatment may be adjusted to the service position to allow for easy replacement of the batteries without unmounting the headrail and without requiring tools. The motorized window treatment may comprise brackets having buttons that may be actuated to release the headrail from a locked position, such that the head rail may be rotated into the service position. The headrail easily rotates through a controlled movement into the service position, such that a user only needs one free hand available to move the motorized window treatment into the service position and change the batteries. | 06-20-2013 |
20130240165 | Motorized Drive Unit Assembly For A Shade System - A motor drive unit assembly for a motorized drapery system having a drapery fabric can include a motor having a drive shaft, an output member rotatable about a drive axis, such that rotation of the output member about the drive axis causes the drapery fabric to move, and a clutch member operatively coupled between the drive shaft of the motor and the output member. The clutch member is configured to automatically couple the output member to the drive shaft such that rotation of the motor drive shaft causes the output member to rotate about the drive axis when the motor drives the drive shaft. The clutch member is further configured to automatically decouple the output member from the motor drive shaft so that the output member rotates about the drive axis relative to the motor drive shaft when the output member is manually driven. | 09-19-2013 |
20130333849 | Window Treatment having an Adjustable Bottom Bar - A window treatment includes mechanisms allowing for easy leveling of a bottom bar of the window treatment without the use of tools and without requiring any portion of the window treatment to be disassembled. The mechanisms allow for incremental adjustment of the amounts of each of two lift cords that extend from the bottom bar to a drive shaft to thus provide fine-tuning adjustment of the levelness of the bottom bar. The mechanisms may be hidden from view on the sides of the bottom bar, such that the mechanisms do not detract from the attractive, aesthetically pleasing appearance of the window treatment. Each lift cord extends from the drive shaft to a pulley of the respective mechanism and wraps around the pulley, such that the amount of the lift cord that extends from the drive shaft to the mechanism may be adjusted in response to rotations of the pulley. | 12-19-2013 |
20140374033 | BATTERY-POWERED MOTORIZED WINDOW TREATMENT HAVING A SERVICE POSITION - A battery-powered motorized window treatment for covering at least a portion of a window may be adjusted into a service position to allow for access to at least one battery that is powering the motorized window treatment. A headrail of the motorized window treatment may be adjusted to the service position to allow for easy replacement of the batteries without unmounting the headrail and without requiring tools. The motorized window treatment may comprise brackets having buttons that may be actuated to release the headrail from a locked position, such that the head rail may be rotated into the service position. The headrail easily rotates through a controlled movement into the service position, such that a user only needs one free hand available to move the motorized window treatment into the service position and change the batteries. | 12-25-2014 |
20150059993 | WINDOW TREATMENT MOUNTING SYSTEM - A window treatment system can be mounted to a plurality of vertical surfaces that separate adjacent windows from each other. The window treatment system can include at least two mounting clips, a window treatment housing and a window treatment assembly (e.g., a motorized roller shade assembly). The at least two mounting clips can be affixed to the plurality of vertical surfaces. As well, the window treatment housing can include a housing clip that is configured to mate with the at least two mounting clips. In this manner, the window treatment housing can be mounted to the plurality of vertical surfaces. | 03-05-2015 |
20150240560 | BATTERY-POWERED MOTORIZED WINDOW TREATMENT HAVING A SERVICE POSITION - A battery-powered motorized window treatment for covering at least a portion of a window may be adjusted into a service position to allow for access to at least one battery that is powering the motorized window treatment. A headrail of the motorized window treatment may be adjusted to the service position to allow for easy replacement of the batteries without unmounting the headrail and without requiring tools. The motorized window treatment may comprise brackets having buttons that may be actuated to release the headrail from a locked position, such that the head rail may be rotated into the service position. The headrail easily rotates through a controlled movement into the service position, such that a user only needs one free hand available to move the motorized window treatment into the service position and change the batteries. | 08-27-2015 |
20150368970 | RETENTION SYSTEMS FOR WINDOW TREATMENT INSTALLATIONS - A window treatment retention system may include a roller shade assembly and one or more retention brackets that at least partially enclose the roller shade assembly and do not interfere with operation of the roller shade assembly. The retention brackets may be configured to absorb an impact force associated with detachment of the roller shade assembly from a mounted position. The retention brackets may deflect upon absorbing the impact force, and may limit displacement of the detached roller shade assembly from the mounted position. The retention brackets may deflect such that the roller shade assembly does not pass through openings defined by the retention brackets. The retention brackets may deflect such that the width of at least one of the openings defined by the retention brackets does not expand beyond a distance that is equivalent to the diameter of a roller tube of the roller shade assembly. | 12-24-2015 |
20160108665 | BATTERY-POWERED MOTORIZED WINDOW TREATMENT HAVING A SERVICE POSITION - A battery-powered motorized window treatment for covering at least a portion of a window may be adjusted into a service position to allow for access to at least one battery that is powering the motorized window treatment. A headrail of the motorized window treatment may be adjusted to the service position to allow for easy replacement of the batteries without unmounting the headrail and without requiring tools. The motorized window treatment may comprise brackets having buttons that may be actuated to release the headrail from a locked position, such that the head rail may be rotated into the service position. The headrail easily rotates through a controlled movement into the service position, such that a user only needs one free hand available to move the motorized window treatment into the service position and change the batteries. | 04-21-2016 |
James M. Wilson, Glen Mill, PA US
Patent application number | Description | Published |
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20140031418 | Regimens and Compositions for AAV-Mediated Passive Immunization of Airborne Pathogens - A prophylactic regimen for passively preventing infection with a pathogen which has a typical route of infection through the nasopharynx region of a subject, e.g., an airborne virus typically transmitted through coughing or sneezing. The method involves specifically targeting a subject's nasopharynx with a viral vector comprising an AAV capsid and carrying a nucleic acid sequence encoding an anti-viral neutralizing antibody construct operably linked to expression control sequences, in order to provide for high levels of expression of the anti-viral neutralizing antibody construct in the nasal airway cells. Optionally, the neutralizing antibody construct is expressed under a promoter which is regulated or induced by a small molecule which is delivered separately from the viral vector. In one embodiment, the method permits transfection of a subject's nasopharynx even where the subject has circulating neutralizing antibodies against the AAV capsid. | 01-30-2014 |
James M. Wilson, Glen Mills, PA US
Patent application number | Description | Published |
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20120189582 | SIMIAN ADENOVIRUS 41 AND USES THEREOF - Novel simian adenovirus 41 and two isolates thereof are described. Various uses of these isolates, including construction of a recombinant vector which comprises simian adenovirus 41 sequences and a heterologous gene under the control of regulatory sequences are provided. A cell line which expresses simian adenovirus 41 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided. | 07-26-2012 |
20130004461 | SUBFAMILY E SIMIAN ADENOVIRUSES A1321, A1325, A1295, A1309, A1316 AND A1322 AND USES THEREOF - Recombinant vectors comprise simian adenovirus A1321 (SAdV-A1321), SAdV-A1325, SAdV-A1295, SAdV-A1309, SAdV-A1316, and/or SAdV-A1322 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-A1321, SAdV-A1325, SAdV-A1295, SAdV-A1309, SAdV-A1316, and/or SAdV-A1322 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided. | 01-03-2013 |
20130023033 | PHARMACOLOGICALLY INDUCED TRANSGENE ABLATION SYSTEM - The present invention relates to gene therapy systems designed for the delivery of a therapeutic product to a subject using replication-defective virus composition(s) engineered with a built-in safety mechanism for ablating the therapeutic gene product, either permanently or temporarily, in response to a pharmacological agent—preferably an oral formulation, e.g., a pill. The invention is based, in part, on the applicants' development of an integrated approach, referred to herein as “PITA” (Pharmacologically Induced Transgene Ablation), for ablating a transgene or negatively regulating transgene expression. In this approach, replication-deficient viruses are used to deliver a transgene encoding a therapeutic product (an RNA or a protein) so that it is expressed in the subject, but can be reversibly or irreversibly turned off by administering the pharmacological agent; e.g., by administration of a small molecule that induces expression of an ablator specific for the transgene or its RNA transcript. | 01-24-2013 |
20130045186 | Method of Detecting and/or Identifying Adeno-Associated Virus (AAV) Sequences and Isolating Novel Sequences Identified Thereby - Adeno-associated virus rh.10 sequences, vectors containing same, and methods of use are provided. | 02-21-2013 |
20130059289 | ADENO-ASSOCIATED VIRUS SEROTYPE I NUCLEIC ACID SEQUENCES, VECTORS AND HOST CELLS CONTAINING SAME - The nucleic acid sequences of adeno-associated virus (AAV) serotype 1 are provided, as are vectors and host cells containing these sequences and functional fragments thereof. Also provided are methods of delivering genes via AAV-1 derived vectors. | 03-07-2013 |
20130309205 | Simian Adenoviruses SAdV-36, -42.1, -42.2, and -44 and Uses Thereof - A recombinant vector comprises simian adenovirus 36, simian adenovirus 42.1, simian adenovirus 42.2 and/or simian adenovirus 44 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus-36, -42.1, -42.2 or -44 gene(s) is also described. Methods of using the vectors and cell lines are provided. | 11-21-2013 |
20130315871 | SUBFAMILY E SIMIAN ADENOVIRUSES A1302, A1320, A1331 AND A1337 AND USES THEREOF - Recombinant vectors comprise simian adenovirus A1302 (SAdV-A1302, SAdV-A1320, SAdV-A1331, and/or SAdV-A1337 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-A1302, SAdV-A1320, SAdV-A1331, and/or SAdV-A1337 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided. | 11-28-2013 |
20130323226 | Compositions and Methods for Altering Tissue Specificity and Improving AAV9-Mediated Gene Transfer - A method of altering the targeting and/or cellular uptake efficiency of an adeno-associated virus (AAV) viral vector having a capsid containing an AAV9 cell surface binding domain is described. The method involves modifying a clade F cell surface receptor which comprises a glycan having a terminal sialic acid residue and a penultimate β-galactose residue. The modification may involve retargeting the vector by temporarily functionally ablate AAV9 binding in a subset of cells, thereby redirecting the vector to another subset of cells. Alternatively, the modification may involve increasing cellular update efficiency by treating the cells with a neuraminidase to expose cell surface β-galactose. Also provided are compositions containing the AAV9 vector and a neuraminidase. Also provided is a method for purifying AAV9 using β-galactose linked to solid support. Also provided are mutant vectors which have been modified to alter their targeting specificity, including mutant AAV9 in which the galactose binding domain is mutated and AAV in which an AAV9 galactose binding domain is engineered. | 12-05-2013 |
20140004143 | ADENO-ASSOCIATED VIRUS (AAV) SEROTYPE 8 SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREFOR | 01-02-2014 |
20140044680 | Simian Subfamily B Adenoviruses SAdV-28, -27, -29, -32, -33, and -35 and Uses Thereof - A recombinant vector comprises simian adenovirus 28, simian adenovirus 27, simian adenovirus 32, simian adenovirus 33, and/or simian adenovirus 35 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus-28, -27, -32, -33, or -35 genes is also disclosed. Methods of using the vectors and cell lines are provided. | 02-13-2014 |
20140065105 | Simian Adenovirus Nucleic Acid and Amino Acid Sequences, Vectors Containing Same, and Methods of Use - A recombinant vector comprises simian adenovirus sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus gene(s) is also disclosed. Methods of using the vectors and cell lines are provided. | 03-06-2014 |
20140155476 | SIMIAN SUBFAMILY E ADENOVIRUSES SAdV-39, -25.2, -26, -30, -37, AND -38 AND USES THEREOF - A recombinant vector comprises simian adenovirus SAdV-39, -25.2, -26, -30, -37, and -38 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-39, -25.2, -26, -30, -37, and -383 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided. | 06-05-2014 |
20140271550 | Constructs and Methods for Delivering Molecules via Viral Vectors with Blunted Innate Immune Responses - A CpG-modified recombinant adeno-associated viral (AAV) vector is described. The vector carries a nucleic acid molecule comprising AAV inverted terminal repeat (ITR) sequences and an exogenous gene sequence under the control of regulatory sequences which control expression of the gene product, in which the nucleic acid sequences carried by the vector are modified to significantly reduce CpG di-nucleotides such that an immune response to the vector is reduced as compared to the unmodified AAV vector. Also provided are methods and regimens for delivering transgenes using these AAV viral vectors, in which the innate immune response to the vector and/or transgene is significantly modulated. | 09-18-2014 |
20140348790 | ADENO-ASSOCIATED VIRUS SEROTYPE I NUCLEIC ACID SEQUENCES, VECTORS AND HOST CELLS CONTAINING SAME - The nucleic acid sequences of adeno-associated virus (AAV) serotype 1 are provided, as are vectors and host cells containing these sequences and functional fragments thereof. Also provided are methods of delivering genes via AAV-1 derived vectors. | 11-27-2014 |
20140356328 | SUBFAMILY E SIMIAN ADENOVIRUSES A1321, A1325, A1295, A1309, A1316 AND A1322 AND USES THEREOF - Recombinant vectors comprise simian adenovirus A1321 (SAdV-A1321), SAdV-A1325, SAdV-A1295, SAdV-A1309, SAdV-A1316, and/or SAdV-A1322 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-A1321, SAdV-A1325, SAdV-A1295, SAdV-A1309, SAdV-A1316, and/or SAdV-A1322 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided. | 12-04-2014 |
20150071962 | SIMIAN ADENOVIRUS 41 AND USES THEREOF - Novel simian adenovirus 41 and two isolates thereof are described. Various uses of these isolates, including construction of a recombinant vector which comprises simian adenovirus 41 sequences and a heterologous gene under the control of regulatory sequences are provided. A cell line which expresses simian adenovirus 41 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided. | 03-12-2015 |
20150139953 | ADENO-ASSOCIATED VIRUS (AAV) SEROTYPE 8 SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREFOR - Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. | 05-21-2015 |
20150152434 | SIMIAN ADENOVIRUSES SAdV-43, -45, -46, -47, -48, -49, AND -50, AND USES THEREOF - A recombinant vector comprises simian adenovirus 43, 45, 46, 47, 48, 49 or 50 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus 43, 45, 46, 47, 48, 49 or 50 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided. | 06-04-2015 |
20150159173 | METHOD OF INCREASING THE FUNCTION OF AN AAV VECTOR - A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences. | 06-11-2015 |
20150176027 | ADENO-ASSOCIATED VIRUS (AAV) SEROTYPE 8 SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREFOR - Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. | 06-25-2015 |
20150230430 | VETERINARY COMPOSITION AND METHODS FOR NON-SURGICAL NEUTERING AND CASTRATION - A method for non-surgical neutering or castration of a non-human mammal for AAV-mediated delivery of an anti-GnRH polypeptide to a non-human animal is described. More particularly, the animal is administered an adeno-associated virus (AAV) vector having an AAV capsid having packaged therein nucleic acid sequences comprising an AAV 5′ inverted terminal repeat (ITR), a sequence encoding a polypeptide which specifically binds gonadotropin releasing hormone (GnRH) under control of regulatory sequences which direct expression of the polypeptide, and an AAV 3′ ITR. A composition comprising the AAV-anti-GnRH may also be used for inhibiting tumor growth in a mammal with a cancer responsive to gonadal steroid hormones. | 08-20-2015 |
20150315612 | ADENO-ASSOCIATED VIRUS (AAV) CLADES, SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREFOR - Sequences of novel adeno-associated virus capsids and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. AAV-mediated delivery of therapeutic and immunogenic genes using the vectors of the invention is also provided. | 11-05-2015 |
20150352203 | SIMIAN ADENOVIRUS NUCLEIC ACID AND AMINO ACID SEQUENCES, VECTORS CONTAINING SAME, AND METHODS OF USE - A recombinant vector comprises simian adenovirus sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus gene(s) is also disclosed. Methods of using the vectors and cell lines are provided. | 12-10-2015 |
20150376649 | ADENO-ASSOCIATED VIRUS SEROTYPE I NUCLEIC ACID SEQUENCES, VECTORS AND HOST CELLS CONTAINING SAME - The nucleic acid sequences of adeno-associated virus (AAV) serotype 1 are provided, as are vectors and host cells containing these sequences and functional fragments thereof. Also provided are methods of delivering genes via AAV-1 derived vectors. | 12-31-2015 |
20160000887 | COMPOSITIONS AND METHODS FOR TREATING MPSI - A vector having an expression cassette having a hIDUA gene having a sequence of SEQ ID NO: 1 or a sequence at least about 95% identical thereto which encodes a functional human alpha-L-iduronidase is provided. The vector may be production vector or a rAAV8. Also provided are compositions containing these vectors and methods of treating MPSI and the symptoms associated with Hurler, Hurle-Scheie and Scheie syndromes. | 01-07-2016 |
20160040137 | SCALABLE PRODUCTION METHOD FOR AAV - A method for producing AAV, without requiring cell lysis, is described. The method involves harvesting AAV from the supernatant. For AAV having capsids with a heparin binding site, the method involves modifying the AAV capsids and/or the culture conditions to ablate the binding between the AAV heparin binding site and the cells, thereby allowing the AAV to pass into the supernatant, i.e., media. Thus, the method of the invention provides supernatant containing high yields of AAV which have a higher degree of purity from cell membranes and intracellular materials, as compared to AAV produced using methods using a cell lysis step. | 02-11-2016 |
20160051603 | Simian Subfamily B Adenoviruses SAdV-28, -27, -29, -32, -33, and -35 and Uses Thereof - A recombinant vector comprises simian adenovirus 28, simian adenovirus 27, simian adenovirus 32, simian adenovirus 33, and/or simian adenovirus 35 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus-28, -27, -32, -33, or -35 genes is also disclosed. Methods of using the vectors and cell lines are provided. | 02-25-2016 |
20160083748 | TISSUE PREFERENTIAL CODON MODIFIED EXPRESSION CASSETTES, VECTORS CONTAINING SAME, AND USES THEREOF - Described herein are synonymously altered gene sequences which express protein in differing levels within secretory as compared to non-secretory target tissue. An expression cassette comprising an open reading frame (ORF) for a protein under the control of regulatory sequences which direct expression of the product in cell, which ORF has been modified to preferentially increase expression levels in a selected tissue, wherein the modified ORF is characterized by a triplet frequency of any one of Tables 3-12, 16 or 17. | 03-24-2016 |
20160083749 | SUBFAMILY E SIMIAN ADENOVIRUSES A1302, A1320, A1331 AND A1337 AND USES THEREOF - Recombinant vectors comprise simian adenovirus A1302 (SAdV-A1302, SAdV-A1320, SAdV-A1331, and/or SAdV-A1337 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-A1302, SAdV-A1320, SAdV-A1331, and/or SAdV-A1337 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided. | 03-24-2016 |
20160097040 | METHOD OF DETECTING AND/OR IDENTIFYING ADENO-ASSOCIATED VIRUS (AAV) SEQUENCES AND ISOLATING NOVEL SEQUENCES IDENTIFIED THEREBY - Adeno-associated virus rh.8 sequences, vectors containing same, and methods of use are provided. | 04-07-2016 |
20160102295 | MODIFIED ADENOVIRUS HEXON PROTEIN AND USES THEREOF - The present invention provides a method of altering the specificity of an adenovirus vector. The method involves providing an adenovirus having a capsid with a modified adenovirus hexon protein. The modified adenovirus has a capsid comprising a hexon protein with a deletion in hypervariable region 1 and/or hypervariable region 4 of the hexon and an insert of an exogenous molecule therein. | 04-14-2016 |
James W. Wilson, Drexel Hill, PA US
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20150010945 | METHODS AND SYSTEMS FOR TRACKING BIOREMEDIATION PROCESSES - A method for expression of engineered constructs containing sequences coding for functional genes of interest in | 01-08-2015 |
Jeanne M. Wilson, Philadelphia, PA US
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20110083232 | MAIZE MICRORNA SEQUENCES - Methods and compositions useful in target sequence suppression and target sequence validation are described. Polynucleotide constructs useful for gene silencing, as well as cells, plants and seeds comprising the polynucleotides and a method for using microRNAs to silence a target sequence are also described. | 04-07-2011 |
John Steven Wilson, Shermansdale, PA US
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20080198565 | SURFACE MOUNT FOOT WITH COINED EDGE SURFACE - A surface mount device having a surface mount foot and a method for making the same is disclosed. The method includes providing a piece of pre-plated conductive stock of a conductive base material and a corrosion-resistant conductive plating material different from the conductive base material at least partially overlying the conductive base material. The stock is cut and formed to create a surface mount device having a surface mount foot extending therefrom. The surface mount foot has a top surface, a plated bottom surface and an at least one unplated side surface intermediate the top and bottom surfaces. The plated bottom surface is swaged to create a new plated coined edge surface intermediate the unplated side surface and the plated bottom surface of the surface mount foot. | 08-21-2008 |
20090117775 | Wire retention connector system - A wire retaining connector, connector system and method of connecting wires to connectors to reduce or eliminate unintentional wire disconnection from wire connectors, including disconnection of poke-in connectors. The connectors and connector systems include a connector body having at least one opening configured to receive a wire, the wire including a partially exposed conductor and insulation. The connector body further includes a wire retention member having at least one surface onto which a wire may be engaged. The wire retention member provides sufficient retention of the wire to resist disconnection of the wire from the connector body. A method for connecting wires to the connectors is also provided. | 05-07-2009 |
20110021085 | Electrical contact with wire trap - An electrical terminal includes a body having a first end, a second end, and a channel having an axis. The channel extends at least through the first end toward the second end, the channel configured and disposed to receive an electrical conductor. A contact gripping element intermediate the first and second ends extends into the channel at an angle from the axis. The contact gripping element is associated with the body. The contact gripping element terminates at an end having a reduced thickness. The contact gripping element is configured to exert a contact gripping contact force on the electrical conductor. | 01-27-2011 |
Justin Wilson, Red Lion, PA US
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20090145680 | ROLL BAR EXHAUST SYSTEM - A roll bar exhaust system [ | 06-11-2009 |
Katie Wilson, Philadelphia, PA US
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20140075276 | DISPLAYING CUSTOMIZED LIST OF LINKS TO CONTENT USING CLIENT-SIDE PROCESSING - A system for providing a customized list of links to content, the customized list of links provided to a user. The system receives a collection of unfiltered links to content, the collection of unfiltered links received from a server. The system hides the collection of unfiltered links from the user. The system receives parameters for customizing the collection of unfiltered links. The parameters are received from the user. The system selectively presents a customized list of links to content to the user, wherein selectively presenting the customized list of links to content comprises presenting a subset of the collection of unfiltered links in accordance with the received parameters. | 03-13-2014 |
Keith Wilson, Pittsburgh, PA US
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20100200130 | License Plate Cover - A license plate cover made from a non-translucent fabric for use by police departments, fire departments, and/or other municipal, state or federal government authorities that can be releasably positioned over a license plate and removed there from without the use of tools. | 08-12-2010 |
Kenneth Wilson, Media, PA US
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20080275031 | Inhibitors of C-FMS Kinase - The invention is directed to compounds of Formula I: | 11-06-2008 |
20110195960 | INHIBITORS OF C-FMS KINASE - The invention is directed to compounds of Formula I: | 08-11-2011 |
Laura Wilson, West Chester, PA US
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20130338466 | NERVE SURVEILLANCE ELECTRODE ASSEMBLY - A nerve surveillance electrode assembly for a surgical access instrument including a substrate, at least one electrode, at least one lead, and a connector such that the nerve surveillance electrode assembly may be selectively applied to a surgical access instrument in such a way that the nerve surveillance electrode assembly is positioned to detect nerves while the surgical access instrument is being advanced toward a surgical target site. | 12-19-2013 |
Leslie Wilson, Schnecksville, PA US
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20140315702 | MACHINE DIRECTION, TRANSVERSE DIRECTION AND ANGLED PRE-APPLIED ZIPPERS IN THE ANGLED AND TRANSVERSE DIRECTION - The present disclosure relates to a method, apparatus and product in the art of reclosable packaging wherein the zipper is sealed to a film structure prior to treatment by the packaging machine for producing a thermoformed package. The zipper can be oriented in the machine direction, the transverse direction or at an angled orientation. | 10-23-2014 |
Lon P. Wilson, Irwin, PA US
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20090005831 | METHOD, APPARATUS AND PROTOCOL FOR SCREENING APPROPRIATE PATIENT CANDIDATES AND FOR CARDIAC RESYCHRONIZATION THERAPY (CRT), DETERMINING CARDIAC FUNCTIONAL RESPONSE TO ADJUSTMENTS OF VENTRICULAR PACING DEVICES AND FOLLOW-UP OF CRT PATIENT OUTCOMES - An apparatus, a method and a protocol for optimizing an implanted device in a candidate. The apparatus comprises a first sensor configured to sense a tracing signal, a transducer configured to capture an image of a region of interest, where the image is captured in synchronism with the tracing signal, and a determiner configured to determine a cardiac functional value based on the image and the tracing signal. A parameter of the implanted device is adjusted based on the cardiac functional value. | 01-01-2009 |
Mark A. Wilson, Sewickley, PA US
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20150208923 | Non-Invasive Monitoring of Tissue Mechanical Properties - Methods and apparatuses for a tissue mechanical property monitoring system are disclosed herein. In one embodiment, a tissue mechanical property monitoring system is disclosed. The tissue mechanical property monitoring system may comprise a probe, wherein the probe comprises a light source and a photodetector; and a main unit, wherein the main unit comprises a microcontroller and wireless transmitter. The probe may be hermetically sealed and may be capable of being implanted onto tissue. The photodetector may be capable of collecting reflectance data from the light emitted by the light source. The reflectance data may be capable of being sorted and processed into tissue mechanical property data such as tissue compliance, vascular resistance, and the like for the tissue illuminated with the probe. | 07-30-2015 |
20150208950 | Arterial and Venous Oxygenation Method and Apparatus - Methods and apparatuses for an oxygen consumption monitoring system are disclosed herein. In one embodiment, an oxygen consumption monitoring system is disclosed. The oxygen consumption monitoring system may comprise a probe, wherein the probe comprises a light source and a photodetector; and a main unit, wherein the main unit comprises a microcontroller and wireless transmitter. The probe may be hermetically sealed and may be capable of being implanted onto tissue. The photodetector may be capable of collecting reflectance data from the light emitted by the light source. The reflectance data may be capable of being sorted into arterial and venous blood oxygen consumption data for the tissue onto which the probe was placed or implanted. The data from the probe may be further sorted and processed to produce perfusion, heart rate, energy expenditure, caloric burn, blood pressure, hemoglobin concentration changes, and tissue oxidative stress. | 07-30-2015 |
Perry Wilson, Philadelphia, PA US
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20140088992 | METHOD AND SYSTEM FOR DETECTING AND CATEGORIZING DISEASE - The presently disclosed subject matter relates to the diagnosis of diseases, and more particularly to the diagnosis of diseases using information contained within an electronic medical record. In particular, the presently disclosed subject matter provides for systems and methods for monitoring, detecting and categorizing disease states. In one embodiment, the system and method can include determining the present or indication of one or more disease state criteria and alerting the hospital information system and at least one clinician if at least one or more disease state criteria are present or indicated. | 03-27-2014 |
Peter P. Wilson, Palmyra, PA US
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20150201514 | ELECTRICAL ASSEMBLY - An electrical assembly includes a first lead, a second lead, and an electrical component extending from a first end to a second end. A first non-electrically conductive adhesive member mechanically connects the first lead to the first end of the electrical component. A second non-electrically conductive adhesive member mechanically connects the second lead to the second end of the electrical component. A first electrically conductive adhesive member electrically connects the first lead to the first end of the electrical component. A second electrically conductive adhesive member electrically connects the second lead to the second end of the electrical component. | 07-16-2015 |
Peter Paul Wilson, Palmyra, PA US
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20100311255 | ELECTRICAL CONNECTOR HAVING AT LEAST ONE HOLE WITH SURFACE MOUNT PROJECTIONS - An electrical connector for electrically coupling an electronic module and an electrical component. The connector includes a connector body that has first and second mating surfaces. The connector body includes interconnects that extend through the connector body between the first and second mating surfaces for electrically coupling the module and the component. The connector body has a hole extending therethrough along a central axis. The hole is configured to receive a guide pin from one of the module and the component. The connector also includes surface mount projections that are coupled to the connector body and extend toward the central axis of the hole. The projections engage and flex against the guide pin when the guide pin is inserted into the hole. The projections form an interference fit with the guide pin to hold the connector body in a mounted position. | 12-09-2010 |
Phillip C. Wilson, Philadelphia, PA US
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20100176661 | COMMUNICATIONS IN MULTIPLE-SWITCH ELECTRICAL CIRCUITS - A system, device and method to allow communications between switches in an electrical circuit containing three-way and four-way switches. The system, device and method allow any switch in an electrical circuit using conventional wiring for three-way and four-way switches to indicate when voltage is being supplied to the electrical load device in the electrical circuit; if a dimmer is present in the electrical circuit, to indicate the dim level of the load device in the electrical circuit and to command to dim level from any switch; and if a timer is present, to allow any switch to provide a warning indication prior to the timer shutting off the load device, and to allow any switch to reset the timer, preventing the shutoff. | 07-15-2010 |
Rachel B. Wilson, Allison Park, PA US
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20100063195 | USE OF NANOPARTICULATE ORGANIC PIGMENTS IN PAINTS AND COATINGS - A protective and decorative coating composition including about 2 to 10 different colorants which in combination with a resinous composition produce a desired visible coating. A majority of the colorants has a maximum haze of about 10% and exhibits an absorbance peak in the visible spectrum wherein at least about 50% of the total absorbance in the visible spectrum occurs at wavelengths within about 50 nm of the wavelength of the peak absorbance. | 03-11-2010 |
Robert B. Wilson, Wynnewood, PA US
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20090285788 | RANDOM RNAi LIBRARIES, METHODS OF GENERATING SAME, AND SCREENING METHODS UTILIZING SAME - This invention provides expression vectors for a ribonucleic acid (RNA) molecule comprising a double-stranded region of random sequence, sets and libraries of same, methods of generating same, and methods for identifying an RNA therapeutic or RNA molecule that has an ability to affect a biological parameter, for identifying a drug target for a disease or disorder of interest, and for identifying a variant of an RNA molecule that has an altered ability to affect a biological parameter of interest. | 11-19-2009 |
20120041023 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION - Methods for improving mitochondrial function, decreasing iron accumulation, and/or decreasing oxidative stress by exposing cells or treating a subject to compounds or compositions of the general formula (I) are described that are beneficial in treating, for example, diseases and conditions such as Friedreich's ataxia, normal aging, and various neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Furthermore, such compounds are useful as probes for identifying defects in mitochondrial metabolism, mitochondrial iron accumulation, cellular stress among other mitochondrial diseases and helping to identify compounds active in overcoming such defects. | 02-16-2012 |
20150210674 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION - Methods for improving mitochondrial function, decreasing iron accumulation, and/or decreasing oxidative stress by exposing cells or treating a subject to compounds or compositions of the general formula | 07-30-2015 |
20160032283 | RANDOM RNAi LIBRARIES, METHODS OF GENERATING SAME, AND SCREENING METHODS UTILIZING SAME - This invention provides expression vectors for a ribonucleic acid (RNA) molecule comprising a double-stranded region of random sequence, sets and libraries of same, methods of generating same, and methods for identifying an RNA therapeutic or RNA molecule that has an ability to affect a biological parameter, for identifying a drug target for a disease or disorder of interest, and for identifying a variant of an RNA molecule that has an altered ability to affect a biological parameter of interest. | 02-04-2016 |
Robert J. Wilson, Warrington, PA US
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20140042678 | 20 Bar super quench vacuum furnace - A vacuum furnace for heat treating and rapid gas quenching insitu a work piece at pressures up to 20 Bar and high gas velocities. The furnace comprises a single chamber having an inner portion including a plurality of graphite heating elements and graphite insulation, an outer portion and an access door. Further included are movable radiation baffle doors. In their closed position hot gases heat treat the work piece. In their open position the hot gases escape through the opening created onto chevron-shaped baffles in the outer portion which reflect radiation heat energy back into the inner portion and diffuse only convective heat energy into a heat exchanger and a variable speed drive recirculating fan. The recirculating fan directs the cooling gases through cooling nozzles onto the work piece to quench it to a pre-programmed temperature. | 02-13-2014 |
20150334778 | High temperature vacuum furnace heater element support assembly - An electrical insulating and heating element support assembly for a high temperature vacuum furnace having a threaded support rod for connecting a heating element to the insulated hot-zone support ring in an electrically non-connected position includes insulator sleeves and washers surrounding the rod in contact with a series of refractory metal washers which may include graphite and/or molybdenum as shielding liners used to protect electrical insulators from having electrical short path means due to deposition of conductive materials onto the non-conducting insulators, and the use of threaded nuts and bushings to anchor the rod and shielding arrangement within the furnace hot zone. The non-conducting insulators and washers are made from materials with high thermal and electrical resistance, such as preferably alumina or mullite, and radially surround the support rod and the heating element. The electrically non-connected shielding washers and nuts, and the rod can be made from graphite or molybdenum, and are designed to be easily disassembled in order to provide relatively easier maintenance service to the vacuum furnace. This design accomplishes the dual objective of supporting both the heating element and the high temperature insulation support ring while remaining electrically non-connected from the heating element. It also allows for variations in thickness of the furnace insulation and heating elements which is common for different furnace designs. This new stand-off assembly is designed to be easily disassembled in order to provide faster maintenance turnaround time and reuse of the stand-off hardware. Another equally important advantage of this design is the absence of holes in the support rod for the placement of pin retainers, and the elimination of the pin retainers, commonly found in prior art vacuum furnace heater element support assembly designs. | 11-19-2015 |
Scott D. Wilson, Denver, PA US
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20150027854 | SUPERCHARGING FEED SYSTEM AND METHOD FOR A BELT IN TUBE CONVEYOR - A system and method for supercharging the feed system for a belt in tube conveyor for agricultural products, which enables achieving a full or near full fill level of the conveyor belt entering the intake end of the conveyor tube. The invention uses a crop delivery apparatus operable to propel an airborne flow of the crop material at least largely in a direction of movement of the conveyor belt, onto the belt surface after formation into a concave shape conforming to a lower portion of the conveyor tube. Additional capabilities include the ability to propel the crop material into an intake end of the conveyor tube, and provision of enclosing structure for containing and focusing the crop material flow. The system can accommodate various angles of tilt and sideward pivotal movement of the conveyor. | 01-29-2015 |
Steve Wilson, Hamburg, PA US
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20110120434 | INJECTION PLATE ASSEMBLY FOR INJECTION OF A PRIMARY FUEL AND AN ACCELERANT - An injection plate assembly for an internal combustion engine that includes a manifold and carburetor or throttle body is provided for injection of a primary fuel and an accelerant into throttle bore(s) of the manifold. The injection plate assembly is adapted to be installed between the manifold and the carburetor. In order to equalize injection of both the primary fuel and the accelerant, the lower plate includes at least two fuel inlet ports that provide fuel at opposing sides of the lower plate. The upper plate includes at least two accelerant or additive inlet ports that provide accelerant to opposite sides of the upper plate, with the accelerant inlet ports being located on different sides of the injection plate assembly from the fuel inlet ports on the lower plate. To further improve flow of the accelerant to the injection gates in the upper plate, the runners in the upper plate define paths that have internal corners having a radius of 0.10 inches or greater. This ensures less head loss for the high pressure accelerant as it is delivered via the runners to the injection gates which normalizes the accelerant delivery from the injection gates at all sides of the main apertures. | 05-26-2011 |
Steven Wilson, Hamburg, PA US
Patent application number | Description | Published |
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20090188480 | Apparatus for Spray Injection of Liquid or Gas - An injection gate ( | 07-30-2009 |
20140034016 | APPARATUS FOR SPRAY INJECTION OF LIQUID OR GAS - An injection gate ( | 02-06-2014 |
20150059704 | APPARATUS FOR SPRAY INJECTION OF LIQUID OR GAS - An injection gate is provided for high pressure, high velocity secondary fluid for admixture of an atomized spray thereof with another or primary fluid that atomizes the other fluid. The secondary fluid may be an accelerant and the primary fluid may be a low pressure fuel or fuel/air mixture in a fuel injection arrangement for an internal combustion engine. An injection plate assembly for an engine is interposed between the carburetor and the manifold), with an array of accelerant injection gates grouped with an array of fuel or fuel/air gates about an aperture coinciding with a throttle bore and evenly balancing the spray about the throttle bore, creating an atomized admixture of accelerant/fuel. The injection of accelerant is directed sharply downwardly toward the center of the bore and through the injected fuel stream, atomizing the fuel thereof for a high efficiency boost of horsepower. | 03-05-2015 |
Steven P. Wilson, New Castle, PA US
Patent application number | Description | Published |
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20100284977 | Expression of Anti-Nociceptive Compounds from Endogenously Regulated Promoters - Expression of anti-nociceptive compounds under the control of endogenously regulated promoters is disclosed. Methods and materials can be used to modify nociception, the process activated by detection of noxious stimuli. The activity of endogenous promoters employed is up-regulated following nociception in animal models of pain. Thus, expression of anti-nociceptive compounds, e.g., proteins, antisense RNAs or micro RNAs, under the control of these promoters can occur in an auto-regulatory, demand-driven manner. Delivery to neurons activated during pain transmission of disclosed expression cassettes containing up-regulated promoters to drive expression of anti-nociceptive compounds can be useful for pain management. | 11-11-2010 |
Suzanne E. Wilson, Philadelphia, PA US
Patent application number | Description | Published |
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20110030160 | BRISTLE CONFIGURATION - A bristle configuration providing enhanced cleaning of teeth. The bristle pattern includes large tufts having a greater cross-sectional area than standard toothbrush bristle tufts. The large tufts are contoured so that the top ends of the bristles comprising the large tufts are not all at the same height. More than one raised section is provided, the raised sections being spatially isolated from one another to function independently of one another. Preferably, at least one of the raised sections has a sufficient brushing surface area with bristles extending a sufficient height above surrounding bristles such that that raised section can reach into and clean interdental tooth surfaces, preferably while the remaining bristles in the large tuft clean other tooth surfaces. Another aspect of the invention relates to a zig-zag or sawtooth bristle profile, wherein each tuft making up the profile has its own unique substantially conical or frustoconical profile. In one embodiment, the height of conical or frustoconical bristle tufts increases from the sides of the head towards the midline of the head. | 02-10-2011 |
Theodore Wilson, Pottstown, PA US
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20140280245 | SYSTEM AND METHOD TO VISUALIZE USER SESSIONS - A system and method operable to identify and analyze persistent state information among a plurality of software-related events, and present persistent state information in a unified fashion. | 09-18-2014 |
Todd P. Wilson, Parkesburg, PA US
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20110260033 | METHOD AND APPARATUS FOR USING GESTURES TO CONTROL A LASER TRACKER - A method for optically communicating, from a user to a laser tracker, a command to control operation of the laser tracker includes steps of providing a rule of correspondence between each of a plurality of commands and each of a plurality of spatial patterns, and selecting by the user a first command from among the plurality of commands. The method further includes the steps of moving by the user, between a first time and a second time, a retroreflector in a first spatial pattern from among the plurality of spatial patterns, wherein the first spatial pattern corresponds to the first command, and projecting a first light from the laser tracker to the retroreflector. The method also includes the steps of reflecting a second light from the retroreflector, the second light being a portion of the first light, and obtaining first sensed data by sensing a third light, the third light being a portion of the second light, wherein the first sensed data is obtained by the laser tracker between the first time and the second time. The method includes also the steps of determining the first command based at least in part on processing the first sensed data according to the rule of correspondence, and executing the first command with the laser tracker. | 10-27-2011 |
20130009035 | METHOD AND APPARATUS FOR USING GESTURES TO CONTROL A LASER TRACKER - A method for optically communicating, from a user to a laser tracker, a command to control operation of the tracker includes providing a rule of correspondence between a plurality of commands and a plurality of positions, each position being a 3-D coordinate; selecting by the user a first command from among the commands and moving by the user a retroreflector to a first position wherein the first position corresponds to the first command. Also, projecting a first light from the tracker to the retroreflector, reflecting a second light from the retroreflector, the second light being a portion of the first light and obtaining first sensed data by sensing a third light, the third light being a portion of the second light. Further, determining the first command based on processing the first sensed data according to the rule of correspondence and executing the first command with the tracker. | 01-10-2013 |
20130010308 | METHOD AND APPARATUS FOR USING GESTURES TO CONTROL A LASER TRACKER - A method for optically communicating, from a user to a six degree-of-freedom (6DOF) laser tracker, a command to control operation of the tracker includes providing a rule of correspondence between commands and pose patterns, each pattern including a change in a coordinate from an initial to a final pose, each pose having three translational coordinates and three orientational coordinates. Also, selecting a first command from among the commands and measuring the coordinate of a first pose of the 6DOF target with the tracker. Further, changing between first and second times, the coordinate of the pose of the target and measuring the coordinate of a second pose of the target with the tracker. Also, determining the first command based on the difference between the measured coordinates of the first and second poses according to the rule of correspondence and executing the first command by the tracker. | 01-10-2013 |
20130037694 | METHOD AND APPARATUS FOR USING GESTURES TO CONTROL A LASER TRACKER - A method for optically communicating, from a user to a laser tracker, a command to control tracker operation includes providing a rule of correspondence between commands and temporal patterns, and selecting by the user a first command. Also, projecting a first light from the tracker to the retroreflector, reflecting a second light from the retroreflector, the second light being a portion of the first light, obtaining first sensed data by sensing a third light which is a portion of the second light, creating by the user, between first and second times, a first temporal pattern which includes a decrease in the third optical power followed by an increase in the third optical power, the first temporal pattern corresponding to the first command, determining the first command based on processing the first sensed data per the rule of correspondence and executing the first command with the tracker. | 02-14-2013 |
20140158860 | METHOD AND APPARATUS FOR USING GESTURES TO CONTROL A LASER TRACKER - Optically communicating from a user to a laser tracker a command to control tracker operation includes providing a rule of correspondence between each of a plurality of commands and temporal patterns; user selecting a first command; projecting a first light from the tracker to a retroreflector; reflecting a second light from the retroreflector that is part of the first light; obtaining first sensed data by sensing a third light imaged onto a photosensitive array that is part of the second light; user creating, between first and second times, a first temporal pattern including at least a decrease in the third light's optical power followed by an increase in its optical power, the first temporal pattern corresponding to the first command; determining the first command based at least in part on processing the first sensed data according to the rule of correspondence; and executing the first command with the tracker. | 06-12-2014 |
Walter Wilson, Bangor, PA US
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20100040493 | Centrifugal turbine blower with gas foil bearings - Disclosed is a centrifugal turbine gas blower with foil bearings for use with a fast axial flow laser. The blower utilizes variable components in order to operate at different speeds for multiple applications. In addition, a bypass load has been incorporated to avoid a surge condition. The blower utilizes foil bearings that are self-lubricating in order to achieve improved efficiency and maximized speeds during operation. The bearings are designed with a bump layer that provides damping for pre-load. Additionally, the backplate of the thrust assembly contains holes in order to reduce the thrust load and to balance the force on the impeller. | 02-18-2010 |
Walter N. Wilson, Bentlyville, PA US
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20140133917 | Apparatus for covering a land area with a heavy wide width flexible sheting - Apparatus for covering a large land area with a long length, wide width heavy flexible sheeting comprising: a main framework adapted for mounting onto the end of a crowd of an excavator; a swivel assembly rotatably secured to the main framework; an elongated support member secured to the swivel assembly; a bearing assembly pivotably fixed to one end of the support member; a bushing assembly pivotably mounted to the other end of the support member; an arbor assembly including an elongated mandrel for receiving and supporting a roll of sheeting with one end of the mandrel journalled at one of its ends in the bushing assembly and the opposite end removably arranged in the bearing assembly. | 05-15-2014 |
Walter Q. Wilson, Bangor, PA US
Patent application number | Description | Published |
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20090129423 | CENTRIFUGAL TURBINE BLOWER WITH GAS FOIL BEARINGS - Disclosed is a centrifugal turbine gas blower with foil bearings for use with a fast axial flow laser. The blower utilizes variable components in order to operate at different speeds for multiple applications. In addition, a bypass load has been incorporated to avoid a surge condition. The blower utilizes foil bearings that are self-lubricating in order to achieve improved efficiency and maximized speeds during operation. The bearings are designed with a bump layer that provides damping for pre-load. Additionally, the backplate of the thrust assembly contains holes in order to reduce the thrust load and to balance the force on the impeller. | 05-21-2009 |
William B. Wilson, Lehigh County, PA US
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20100314713 | Integrated Circuit Inductors with Reduced Magnetic Coupling - An IC inductor structure is provided which includes a first inductor element formed on a semiconductor substrate and at least a second inductor element formed on the semiconductor substrate proximate the first inductor element. The first inductor element has a first effective magnetic field direction associated therewith, and the second inductor element has a second effective magnetic field direction associated therewith. The first and second inductor elements are oriented relative to one another so as to create a non-zero angle between the first and second effective magnetic field directions. | 12-16-2010 |
William B. Wilson, Macungle, PA US
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20090108890 | Internal Supply Voltage Controlled PLL and Methods for Using Such - Various embodiments of the present invention provide systems and circuits for clock signal generation. For example, various embodiments of the present invention provide semiconductor devices that include a power source and a phase lock loop circuit. The power source provides a supply voltage to the phase lock loop circuit. The phase lock loop circuit includes and on-chip control voltage source and a voltage controlled oscillator. The on-chip control voltage source is capable of producing a control voltage that varies between a minimum voltage and a maximum voltage. The voltage controlled oscillator receives the control voltage and provides a clock signal with a frequency corresponding to the control voltage. The maximum voltage is greater than the supply voltage. For example, in some embodiments of the present invention, the maximum voltage is more than double the supply voltage. As another example, in some embodiments of the present invention, the maximum voltage is more than six times the supply voltage. | 04-30-2009 |
William B. Wilson, Macungie, PA US
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20090108881 | Latch-Based Sense Amplifier - Various embodiments of the present invention provide systems and circuits for processing information through comparison of input signals. For example, various embodiments of the present invention provide differential latch circuits. Such differential latch circuits include an input stage and a latch stage. The input stage provides an interim output that is available during a defined period, and the latch stage is operable to latch the temporary interim output during the defined period using a common clock. | 04-30-2009 |
20100054383 | METHODS AND APPARATUS FOR GENERATING EARLY OR LATE SAMPLING CLOCKS FOR CDR DATA RECOVERY - Methods and apparatus are provided for a clock phase generator for CDR data sampling that generates early and/or late sampling clocks, relative to ideal transition and sample points. An early sampling clock is generated by generating a plurality of transition and data sampling clock signals having a substantially uniform phase separation; and delaying at least one of the transition clock signals to generate one or more early clock signals. A late sampling clock is generated by generating a plurality of transition and data sampling clock signals having a substantially uniform phase separation; and delaying at least one of the data sampling clock signals to generate one or more late clock signals. The early clock signals can be employed, for example, in a threshold-based decision feedback equalizer. The late clock signals can be employed, for example, in a classical decision feedback equalizer. | 03-04-2010 |
William Burdett Wilson, Macungie, PA US
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20140077850 | Jitter Suppression In Type I Delay-Locked Loops - In one embodiment, a delay-locked loop (DLL) for synchronizing a phase of a periodic digital output signal with a phase of a periodic digital input signal includes a deskew element responsive to the periodic digital input signal to the DLL and the periodic digital output signal from the DLL for suppressing jitter in the periodic digital output signal by synchronizing transitions in the periodic digital output signal with transitions in the periodic digital input signal and generating a final jitter-suppressed periodic digital output signal. | 03-20-2014 |