Williams, Nottingham
Hywel Williams, Nottingham GB
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20120143082 | TISSUE SAMPLE ANALYSIS - A new method of Raman micro spectroscopy for the detection and imaging of Basal Cell Carcinoma (BCC) comprises the application of a multivariate supervised statistical classification model to distinguish between dermis, epidermis and BCC. The resulting Raman images provide a tool for the automated and objective evaluation of a tissue sample. | 06-07-2012 |
John Gareth Williams, Nottingham GB
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20130338104 | 3-Substituted-4-Oxo-3,4-Dihydro-Imidazo[5,1-d]1,2,3,5-Tetrazine-8-Carboxyl- ic Acid Amides and Their Use - The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain 3-substituted-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid amide (collectively referred to herein as 3TM compounds). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit cell proliferation, and in the treatment of proliferative disorders such as cancer, etc., and methods of preparing such compounds. | 12-19-2013 |
Jonathan Gareth Williams, Nottingham GB
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20100087515 | IKK-BETA SERINE-THREONINE PROTEIN KINASE INHIBITORS - Compounds of formula (IA) or (IB) are inhibitors of IkB kinase (IKK) activity, and are useful in the treatment of autoimmune and inflammatory diseases: Formula (A) and (B) wherein R | 04-08-2010 |
20110212962 | P38 MAP KINASE INHIBITORS - There are provided inter alia compounds of formula (I) wherein R | 09-01-2011 |
20110269800 | P38 MAP KINASE INHIBITORS - There is provided a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, including all tautomers thereof, compositions comprising the same, use of said compound and compositions for treatment, in particular for the treatment of asthma and COPD, and processes for the preparation of said compound. | 11-03-2011 |
20110294812 | P38 MAP KINASE INHIBITORS - The invention relates to compounds of formula (I): | 12-01-2011 |
20110312963 | P38 MAP KINASE INHIBITORS - The present disclosure relates to compounds of formula (I): | 12-22-2011 |
20120136031 | P38MAP KINASE INHIBITOR - The present invention relates to a compound of formula (I): | 05-31-2012 |
20130012512 | P38 MAP kinase inhibitors - There are provided inter alia compounds of formula (I) | 01-10-2013 |
20130029990 | PYRAZOLE P38 MAP KINASE INHIBITORS - There are provided inter alia compounds of formula (I): wherein R | 01-31-2013 |
20130040962 | P38 MAP Kinase Inhibitors - There is provided a compound of formula (I): wherein: J represents (A): or (B): compositions comprising same, processes for preparing said compounds and use thereof in treatment, particularly in the treatment of inflammatory disease, such as asthma, COPD and 15 rheumatoid arthritis. | 02-14-2013 |
20130040995 | NOVEL COMPOUNDS - There is provided inter alia a compound of formula (I): | 02-14-2013 |
20130156826 | RESPIRATORY FORMULATIONS AND COMPOUNDS FOR USE THEREIN - The present invention relates to respiratory formulations comprising a compound of formula (I): and use of said compounds and compositions in treatment, for example in the treatment of an inflammatory disease or a respiratory disorder, in particular an inflammatory mediated and/or virally mediated respiratory disorder such as asthma and COPD or the treatment or prevention of viral infection, for example infection by influenza virus, rhinovirus or RSV. The invention also extends to certain novel compounds of formula (I). | 06-20-2013 |
20140057915 | KINASE INHIBITORS - There are provided compounds of formula I, | 02-27-2014 |
Jonathon Gareth Williams, Nottingham GB
Patent application number | Description | Published |
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20100069473 | Inhibitors Of IKK-Beta Serine-Threonine Protein Kinase - Compounds of formula (IA) or (IB) are inhibitors of IkB kinase (IKK) activity, and are useful in the treatment of autoimmune and inflammatory diseases: | 03-18-2010 |
20110039920 | INHIBITORS OF IKK-BETA SERINE-THERONINE PROTEIN KINASE - Cyclopentyl(2S,4E)-2-amino-5-{3-[4-carbamoyl-5(carbamoylamino)-2-thienyl]phenyl}pent-4-enoate; Cyclopentyl 5-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]phenyl}-L-norvalinate; Cyclopentyl(2S,4E)-2-amino-5-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]-5-methylphenyl}pent-4-enoate; Cyclopentyl(25,4E)-2-amino-5-{5-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]-2-methylphenyl}pent-4-enoate; Cyclopentyl O-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]phenyl}-L-homoserinate; Cyclopentyl O-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]phenyl}-L-homoserinate; Cyclopentyl N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzyl}-L-alaninate; and tert-Butyl N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzyl}-L-alaninate are hydrolysed to the corresponding carboxylic acids by intracellular carboxylesterases, and are useful for the inhibition of IKKβ activity. | 02-17-2011 |
Paul Williams, Nottingham GB
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20110183867 | Polymer arrays for biofilm adhesion testing - This invention relates to a method of screening arrays of polymers having pre-determined surface energies. The polymer arrays of the present invention can be used to screen for microorganism adherence. More specifically the arrays can be used to screen for adherence of particular bacteria or fungi to particular polymers in the array. Furthermore, this invention relates to a method combining in-situ polymer synthesis with physico-chemical characterisation of the resulting polymer array and subsequent biological assays of bacterial or fungal adherence. This allows for high throughput screening and characterisation of candidate polymers which are not susceptible to bacterial or fungal adherence or which can be used to support bacterial or fungal adherence where such is required. The arrays can also be used to screen for inhibition or promotion of biofilm formation. | 07-28-2011 |
20140314826 | NOVEL POLYMERS WHICH RESIST BACTERIAL ATTACHMENT - The invention provides a method for inhibiting bacterial attachment to a surface, the method comprising forming the surface from a polymer, or applying a polymer to the surface, wherein the polymer is a homopolymer formed from a (meth) acrylate or (meth) acrylamide monomer or a copolymer formed from one or more (meth) acrylate or (meth) acrylamide monomers, wherein the (meth) acrylate or (meth) acrylamide monomers are of formula (I) or (II): | 10-23-2014 |