Westbrook
Cameron Dean Westbrook, Devon CA
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20090196747 | COMPACT VARIABLE PITCH FAN - A compact variable pitch fan has a hydraulic pitch change mechanism. A pitch change piston is constrained to follow reciprocating motion under hydraulic control within a peripheral hub from which fan blades extend outward. An additional feature is the use of separated guiding and seal surfaces. A still further feature is the use of a pitch sensor, particularly on the hydraulic line leading to the variable pitch fan. | 08-06-2009 |
Jules Westbrook, Dublin IE
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20090275495 | METHODS AND COMPOSITIONS RELATING TO ALZHEIMER'S DISEASE - Methods and compositions relating to Alzheimer's disease are provided, including proteins that are differentially expressed in Alzheimer's disease as compared to the normal state. Further provided are methods, particularly experimental paradigms, for the identification of differential expressed proteins that are potential molecular targets for compounds to treat or prevent Alzheimer's disease. Also provided are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease. | 11-05-2009 |
20110165146 | METHODS OF DIAGNOSING ALZHEIMER'S DISEASE - Methods and compositions relating to Alzheimer's disease are provided. Specifically, proteins that are differentially expressed in the Alzheimer's disease state relative to their expression in the normal state are provided. Proteins associated with Alzheimer's disease are identified and described. Methods of diagnosis of Alzheimer's disease using the differentially expressed proteins are also provided, as are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease. | 07-07-2011 |
Jules Arthur Westbrook, Middlesex GB
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20080213802 | Diagnosis of Neurodegenerative Diseases - The invention relates to a method of diagnosis of vCJD in a diagnostic sample of a valid body tissue taken from a human subject, which comprises detecting an increased concentration of a protein in the diagnostic sample, compared with a sample of a control human subject, the protein being: beta-actin (SwissProt Ace. No. P60709), apolipoprotein A-IV precursor (SwissProt Acc. No. P06727); haptoglobin beta-chain consisting of residues 162-406 (SwissProt Acc. No. P00738); haemoglobin beta chain (SwissProt Ace. No. P02023); or alpha-1-antitrypsin (SwissProt Ace. No. P01009); or a decreased concentration of a protein in the diagnostic sample, compared with a sample of a control, normal human subject, the protein being plasma protease (C1) inhibitor precursor (SwissProt Acc. No. P05155); complement component 1, s sub-component (SwissProt Acc. No. P09871); butyrylcholinesterase precursor (SwissProt Acc. No. P06276); complement component C4B (SwissProt Acc. No. P01028); lumican (SwissProt Ace. No. P51884); alpha-fibrinogen precursor (SwissProt Ace. No. P02671); IGHG4 protein (Swiss Prot Ace. No. Q8TC63) or immunoglobulin lambda heavy chain. Other marker proteins are also disclosed. | 09-04-2008 |
Jules Arthur Westbrook, Middelesex GB
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20080286263 | Diagnosis Of Neurodegenerative Diseases - The invention relates to a method of diagnosis of Huntington's Disease in a diagnostic sample of a valid body tissue taken from a human subject, which comprises detecting an altered concentration of a protein in the diagnostic sample, compared with a sample of a control human subject, the protein being selected from: Swiss Prot accession number: Protein name; P10909: Clusterin precursor; P00738: Haptoglobin precursor; P01009: Alpha-1-antitrypsin precursor; P01024: Complement C3 precursor; P01620: 1 g kappa chain V-III region; P01834: 1 g kappa chain C region P01842: 1 g lambda chain C regions; P01857: 1 g gamma-1 chain C region; P01859: Ig gamma-2 chain C region; P01876: 1 g alpha-1 chain C region P02647: Apolipoprotein A-I precursor; P02649: Apolipoprotein E precursor; P02652: Apolipoprotein A-II precursor; P02655: Apolipoprotein C-II precursor; P02656: Apolipoprotein C-II precursor P02671: Fibrinogen alpha/alpha-E chain precursor; P02763: Alpha-1-acid glycoprotein 1 precursor; P02766: Transthyretin precursor; P02768: Serum albumin precursor; P02787: Serotransferrin precursor; P04196: Histidine-rich glycoprotein precursor; P06727: Apolipoprotein A-IV precursor; P19652: Alpha-1-acid glycoprotein 2 precursor; P68871/P02042: Hemoglobin beta chain/Hemoglobin delta chain; P60709: Beta actin. | 11-20-2008 |
Ryan Westbrook, Kitchener CA
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20130263891 | METHOD AND APPARATUS FOR REMOVING FOREIGN MATERIAL FROM AN UPWARDLY ORIENTED SURFACE OF A BODY-IN-WHITE - A method and apparatus for removing foreign material from an upwardly oriented surface of a body-in-white. The apparatus includes a vacuum member mounted to a frame for removing foreign material from the associated upwardly oriented surface and a soft-material brush mounted to the frame rearward of the vacuum member as defined by the direction of forward travel of the vehicle. The apparatus may also vertical adjustment device(s) configured to adjust and maintain vertical distance between the apparatus relative to the associated vehicle. Also disclosed herein is a method for removing foreign material from an upwardly oriented surface of a body-in-white that comprises using bringing the apparatus defined herein in proximate contact with at least one surface of a body-in-white as it progresses down a vehicle assembly line. | 10-10-2013 |
Ryan Robert Westbrook, Kitchener CA
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20100122968 | METHOD FOR IMPLEMENTING SPATTER-LESS WELDING - A method for optimizing a schedule for impulse welding including generating a weld lobe using a preexisting welding schedule, the schedule prescribing a current, a weld time, and a pressure; identifying an operating window on the weld lobe; analyzing the operating window, the analysis including determining a maximum time range of the operating window, and determining a maximum current range of the operating window; until (i) the determined maximum time range of the operating window is greater than a predetermined percentage of the prescribed weld time of the schedule and (ii) the determined maximum current range is greater than the prescribed current of the schedule, creating additional weld lobes by varying the pressure and repeating the identifying an operating window and the analyzing the operating window steps; and selecting, within the operating window satisfying conditions (i) and (ii), a second schedule including a second weld time, a second current, and a second pressure. | 05-20-2010 |
Simon Westbrook, London GB
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20150037335 | THERAPEUTIC USE OF P75NTR NEUROTROPHIN BINDING PROTEIN - The present invention relates to a p75NTR neurotrophin binding protein, p75NTR(NBP), for use in the treatment of pain and/or a symptom of pain. | 02-05-2015 |
Simon Lemprier Westbrook, Sandwich GB
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20110039899 | Gabapentin for the Treatment of Overactive Bladder, Stress Incontinence and BPH - Use of an alpha-2-delta ligand, or a pharmaceutically acceptable derivative thereof, for the manufacture of a medicament for the treatment of LUTS, other than urinary incontinence, associated with OAB and/or BPH. | 02-17-2011 |
Simon Lempriere Westbrook, Kent GB
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20080234280 | Use of Mc4 Receptor Agonist Compounds - This invention relates to the use of an MC4 receptor agonist compound for the manufacture of a medicament for the treatment of lower urinary tract dysfunction. | 09-25-2008 |