Valenzano
Anthony Valenzano, Archbald, PA US
Patent application number | Description | Published |
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20110101842 | Distributed Element Light-Emitting-Diode (LED) Light Fixture - The invention is a distributed element LED light bulb | 05-05-2011 |
20130060491 | Thermal Mass Flow Meter - A thermal mass flow meter is disclosed wherein a sensor board with at least one heating element and at least two temperature sensors locates inside a housing where the gas or fluid is flowing. The heating element is turned on and off and a microprocessor is programmed to calculate a flow rate based on a logarithmic function of temperature differences between a pair of sensor before the heating cycle and after the heating cycle. | 03-07-2013 |
20130060492 | Method of deducing time based metrics using flow rate - A method of deducing time based metrics using flow rate is disclosed. The method uses a thermal mass flow meter wherein the meter comprises a pipe housing and a sensor board with at least one heating element and at least two temperature sensors is located inside the pipe and where a microprocessor is programmed to calculate a flow rate based on a logarithmic function of difference between base line temperature difference between temperature sensors before heating element is turned on and a second temperature difference between the temperature sensors after heating element is turned on. Duration of gas supply is provided by using the measured flow rate and information of the gas supply. | 03-07-2013 |
20140149067 | IMPACT AND ACCELERATION DETECTION - An sensor system measures acceleration and detects impacts. According one embodiment of the present invention, an impact sensor system attaches to a helmet, detects impacts, and displays indications of single and cumulative impacts. Identifying impacts when they occur can help identify players to be screened for concussion or taken out of action before they show symptoms. This can help prevent concussions that result from cumulative hits, which are often more dangerous than those that result from a single hit. The system serves as a continue-to-play decision support aid. | 05-29-2014 |
Ken Valenzano, East Brunswick, NJ US
Patent application number | Description | Published |
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20100119502 | THERAPY REGIMENS, DOSING REGIMENS AND STABLE MEDICAMENTS FOR THE TREATMENT OF POMPE DISEASE - The present application provides a method for treating Pompe disease in a subject in need thereof, that includes a method of administering to the subject a GAA enzyme in combination with an ASSC for the GAA enzyme. The present application also provides methods for increasing the in vitro and in vivo stability of a GAA enzyme formulation. | 05-13-2010 |
20110268721 | Therapy Regimens, Dosing Regimens And Stable Medicaments For The Treatment Of Pompe Disease - The present application provides a method for treating Pompe disease in a subject in need thereof, that includes a method of administering to the subject a GAA enzyme in combination with an ASSC for the GAA enzyme. The present application also provides methods for increasing the in vitro and in vivo stability of a GAA enzyme formulation. | 11-03-2011 |
Ken Valenzano, Cranbury, NJ US
Patent application number | Description | Published |
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20090312345 | PHARMACOLOGICAL CHAPERONES FOR TREATING OBESITY - The invention relates to methods of enhancing normal melanocortin-4 receptor (MC4R) activity, and to enhancing activity of an MC4R having a mutation which affects protein folding and/or processing of the MC4R. The invention provides a method of treating an individual having a condition in which increased activity of an MC4R at the cell surface would be beneficial, for example in obesity, by administering an effective amount of a pharmacological chaperone for the MC4R. The invention provides MC4R pharmacological chaperones which enhance the activity of MC4R. The invention further provides a method of screening to identify pharmacological chaperones which enhance folding of an MC4R in the endoplasmic reticulum (ER), in order to enhance the activity of the MC4R at the cell surface. | 12-17-2009 |
Kenneth Valenzano, East Brunswick, NJ US
Patent application number | Description | Published |
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20120309788 | Method for Treating Alzheimer's Disease Using Pharmacological Chaperones To Increase The Activity of Gangliosidases - The present invention relates to a method for treating an individual having Alzheimer's Disease by using pharmacological chaperones to increase the activity of gangliosidase and/or sialidase enzymes involved in ganglioside catabolism. | 12-06-2012 |
20140193390 | High Concentration Alpha-Glucosidase Compositions for the Treatment of Pompe Disease - The present application provides for compositions comprising high concentrations of acid α-glucosidase in combination with an active site-specific chaperone for the acid α-glucosidase, and methods for treating Pompe disease in a subject in need thereof, that includes a method of administering to the subject such compositions. The present application also provides methods for increasing the in vitro and in vivo stability of an acid α-glucosidase enzyme formulation. | 07-10-2014 |
Kenneth Joseph Valenzano, East Brunswick, NJ US
Patent application number | Description | Published |
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20140219986 | DOSING REGIMENS FOR THE TREATMENT OF FABRY DISEASE - The presently disclosed subject matter provides a dosing regimen and administration schedule for the use of 1-deoxygalactonojirimycin and enzyme replacement therapy for the treatment of Fabry disease. The presently disclosed subject matter further provides a dosing regimen and administration schedule for the use of migalastat hydrochloride and agalsidase for the treatment of Fabry disease. | 08-07-2014 |
20150044194 | High Concentration Alpha-Glucosidase Compositions for the Treatment of Pompe Disease - The present application provides for compositions comprising high concentrations of acid α-glucosidase in combination with an active site-specific chaperone for the acid α-glucosidase, and methods for treating Pompe disease in a subject in need thereof, that includes a method of administering to the subject such compositions. The present application also provides methods for increasing the in vitro and in vivo stability of an acid α-glucosidase enzyme formulation. | 02-12-2015 |
20150086530 | DOSING REGIMENS FOR THE TREATMENT OF POMPE DISEASE - The presently disclosed subject matter provides a dosing regimen and administration schedule for the use of 1-deoxynojirimycin and enzyme replacement therapy for the treatment of Pompe disease. The presently disclosed subject matter further provides a dosing regimen and administration schedule for the use of 1-deoxynojirimycin hydrochloride and alglucosidase alfa for the treatment of Pompe disease. | 03-26-2015 |