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| 20130086177 | SYSTEMS AND METHODS OF ADJUSTING CONTACT IMPORTANCE FOR A COMPUTING DEVICE - A list of contacts is stored in at least one contact repository such as an address book of an electronic device. Contacts can be assigned an importance value. An importance value is determined for contacts based on criteria such as the recentness that a contact's information was updated or revised, how recently the contact was added to an electronic device's address book, whether a contact's website was recently accessed by an electronic device, the identity of a contact or the nature of the relationship between a contact and an electronic device. Contact importance criteria can be set in response to selections and inputs, for example via the use of slider bar on a display. Contacts can be dynamically ranked according to their importance and a ranked list of contacts can be displayed. | 04-04-2013 |
| 20130198680 | MANAGING LINKED CONTACT RECORDS CONTAINING INFORMATION FROM MULTIPLE SOURCE RECORDS - The present disclosure provides for management of linked contact records containing information from multiple source records. User interfaces and methodologies for displaying and managing a linked contact record of a contact allow the linked contact record to be readily and selectively managed. A user can interact with a user interface in order to selectively add, remove, and re-store links to a linked contact record of a contact. | 08-01-2013 |
| 20140047537 | ACCESSING CONTACT RECORDS IN A DEVICE WITH MULTIPLE OPERATION PERIMETERS - A method and apparatus for accessing contact records in an electronic device with multiple operation perimeters is provided. When accessing contact records from within one operation perimeter, only contact information accessible from that operation perimeter is retrieved. An option is provided to also access contact records of an alternative operation perimeter. If the alternative operation perimeter has a higher security level than the current operation perimeter, a password or other authorization may be required. The contact records may be accessed, for example, to find information for an outgoing communication, to identify information associated with an incoming communication, or to edit a contact record. | 02-13-2014 |
| 20140047564 | MANAGING CONTACT RECORDS IN A DEVICE WITH MULTIPLE OPERATION PERIMETERS - Management of contact records in an electronic device with multiple operation perimeters is provided. When creating a contact record from within one operation perimeter, an option is provided to save the contact record in storage resource accessible from within the current operating perimeter or in a storage resource accessible from within an alternative operation perimeter. If the alternative operation perimeter has a higher security level than the current operation perimeter, a password or other authorization may be required. | 02-13-2014 |
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| 20100006346 | WEIGH ON THE FLY - Methods and apparatus for weighing an article, such as a mail piece, while the article is moving at high speed. An article ( | 01-14-2010 |
| 20100082389 | POSTAL SERVICE REVENUE PROTECTION WITH REAL-TIME PROCESSING - Methods and apparatus for weighing an article, such as a mail piece, while the article is moving at high speed, and for checking that the correct amount of postage has been paid for delivery of the article. An article ( | 04-01-2010 |
| 20110290569 | WEIGH ON THE FLY - Methods and apparatus for weighing an article, such as a mail piece, while the article is moving at high speed. An article ( | 12-01-2011 |
| 20120166362 | POSTAL SERVICE REVENUE PROTECTION WITH REAL-TIME PROCESSING - Methods and apparatus for weighing an article, such as a mail piece, while the article is moving at high speed, and for checking that the correct amount of postage has been paid for delivery of the article. An article ( | 06-28-2012 |
| 20120285751 | IN-LINE CONVEYOR SCALE WITH INTEGRATED CLOSED-LOOP SERVO SENSOR - Disclosed are various applications of differential torque sensing, seeking to maximize the sensing power of servo motors in applications that have a wide torque range. In one embodiment, a transmission ( | 11-15-2012 |
| 20130239648 | DYNAMIC THICKNESS ADAPTATION FOR AN IN-LINE SCALE - Methods and apparatus for weighing an article, such as a mail piece, while the article is moving at high speed. An article ( | 09-19-2013 |
| 20140327383 | PARCEL AND MASS FLOW SCALE - Weighing system (FIG. | 11-06-2014 |
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| 20090071728 | WEIGH ON THE FLY - Methods and apparatus for weighing an article, such as a mail piece, while the article is moving, for example along a transport path (FIG. | 03-19-2009 |
| 20100282521 | ACTIVE ELECTRONIC DAMPING FOR AN IN-LINE SCALE - Methods and apparatus for weighing an article, such as a mail piece, while the article is moving at high speed, for example along a transport of a sorter machine. An article ( | 11-11-2010 |
| 20100294572 | DYNAMIC THICKNESS ADAPTATION FOR AN IN-LINE SCALE - Methods and apparatus for weighing an article, such as a mail piece, while the article is moving at high speed. An article ( | 11-25-2010 |
| 20110004441 | FLATBED WEIGH SYSTEM WITH VACUUM CAPSTAN ROLLER - A flatbed weigh system and methods for weighing substantially flat articles such as mail flats while they are moving. A weigh system has an intake plate ( | 01-06-2011 |
| 20130084010 | IN-FIELD DEVICE FOR DE-CENTRALIZED WORKFLOW AUTOMATION - In one example, a system is provided. The system includes a portable, in-field unit including: a tag reader to acquire an ID tag identifier from a tag located in or on a physical item positioned within functional range of the in-field unit tag reader; a digital processor arranged for executing software code stored in the in-field unit responsive to the acquired ID tag identifier, the stored software code including—a customer application layer; and a database adapter component configured to provide database services to the processor; wherein the database services include accessing a stored database to acquire stored data associated with the acquired ID tag identifier. | 04-04-2013 |
| 20150025932 | IN-FIELD DEVICE FOR DE-CENTRALIZED WORKFLOW AUTOMATION - In one example, a system is provided. The system includes a portable, in-field unit including: a tag reader to acquire an ID tag identifier from a tag located in or on a physical item positioned within functional range of the in-field unit tag reader; a digital processor arranged for executing software code stored in the in-field unit responsive to the acquired ID tag identifier, the stored software code including—a customer application layer; and a database adapter component configured to provide database services to the processor; wherein the database services include accessing a stored database to acquire stored data associated with the acquired ID tag identifier. | 01-22-2015 |
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| 20100069263 | SEQUENCE TAG DIRECTED SUBASSEMBLY OF SHORT SEQUENCING READS INTO LONG SEQUENCING READS - The invention provides compositions and methods for preparing DNA sequencing libraries. In particular, the method relates to preparing DNA sequencing libraries from kilobase scale nucleic acids. The invention also provides methods for assembling short read sequencing data into longer contiguous sequences. The method is useful for various applications in genomics, including genome assembly, full length cDNA sequencing, metagenomics, and the analysis of repetitive sequences of assembled genomes. | 03-18-2010 |
| 20130137588 | SEQUENCE TAG DIRECTED SUBASSEMBLY OF SHORT SEQUENCING READS INTO LONG SEQUENCING READS - The invention provides compositions and methods for preparing DNA sequencing libraries. In particular, the method relates to preparing DNA sequencing libraries from kilobase scale nucleic acids. The invention also provides methods for assembling short read sequencing data into longer contiguous sequences. The method is useful for various applications in genomics, including genome assembly, full length cDNA sequencing, metagenomics, and the analysis of repetitive sequences of assembled genomes. | 05-30-2013 |
| 20130137605 | SEQUENCE TAG DIRECTED SUBASSEMBLY OF SHORT SEQUENCING READS INTO LONG SEQUENCING READS - The invention provides methods for preparing DNA sequencing libraries by assembling short read sequencing data into longer contiguous sequences for genome assembly, full length cDNA sequencing, metagenomics, and the analysis of repetitive sequences of assembled genomes. | 05-30-2013 |
| 20150133344 | SEQUENCE TAG DIRECTED SUBASSEMBLY OF SHORT SEQUENCING READS INTO LONG SEQUENCING READS - The invention provides methods for preparing DNA sequencing libraries by assembling short read sequencing data into longer contiguous sequences for genome assembly, full length cDNA sequencing, metagenomics, and the analysis of repetitive sequences of assembled genomes. | 05-14-2015 |
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| 20090326406 | WEARABLE ELECTROMYOGRAPHY-BASED CONTROLLERS FOR HUMAN-COMPUTER INTERFACE - A “Wearable Electromyography-Based Controller” includes a plurality of Electromyography (EMG) sensors and provides a wired or wireless human-computer interface (HCl) for interacting with computing systems and attached devices via electrical signals generated by specific movement of the user's muscles. Following initial automated self-calibration and positional localization processes, measurement and interpretation of muscle generated electrical signals is accomplished by sampling signals from the EMG sensors of the Wearable Electromyography-Based Controller. In operation, the Wearable Electromyography-Based Controller is donned by the user and placed into a coarsely approximate position on the surface of the user's skin. Automated cues or instructions are then provided to the user for fine-tuning placement of the Wearable Electromyography-Based Controller. Examples of Wearable Electromyography-Based Controllers include articles of manufacture, such as an armband, wristwatch, or article of clothing having a plurality of integrated EMG-based sensor nodes and associated electronics. | 12-31-2009 |
| 20100244767 | MAGNETIC INDUCTIVE CHARGING WITH LOW FAR FIELDS - A charging station wirelessly transmits power to mobile electronic devices (MEDs) each having a planar-shaped receiver coil (RC) and a capacitor connected in parallel across the RC. The station includes a planar charging surface, a number of series-interconnected bank A source coils (SCs), a number of series-interconnected bank B SCs, and electronics for energizing the SCs. Each SC generates a flux field perpendicular to the charging surface. The bank A and bank B SCs are interleaved and alternately energized in a repeating duty cycle. The coils in each bank are also alternately wound in a different direction so that the fields cancel each other out in a far-field environment. Whenever an MED is placed in close proximity to the charging surface, the fields wirelessly induce power in the RC. The MEDs can have any two-dimensional orientation with respect to the charging surface. | 09-30-2010 |
| 20120188158 | WEARABLE ELECTROMYOGRAPHY-BASED HUMAN-COMPUTER INTERFACE - A “Wearable Electromyography-Based Controller” includes a plurality of Electromyography (EMG) sensors and provides a wired or wireless human-computer interface (HCl) for interacting with computing systems and attached devices via electrical signals generated by specific movement of the user's muscles. Following initial automated self-calibration and positional localization processes, measurement and interpretation of muscle generated electrical signals is accomplished by sampling signals from the EMG sensors of the Wearable Electromyography-Based Controller. In operation, the Wearable Electromyography-Based Controller is donned by the user and placed into a coarsely approximate position on the surface of the user's skin. Automated cues or instructions are then provided to the user for fine-tuning placement of the Wearable Electromyography-Based Controller. Examples of Wearable Electromyography-Based Controllers include articles of manufacture, such as an armband, wristwatch, or article of clothing having a plurality of integrated EMG-based sensor nodes and associated electronics. | 07-26-2012 |
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| 20090256443 | HOLLOW RING TORUS MAGNET GENERATOR - A hollow ring torus permanent magnet generator, with a sphere shaped permanent magnet which spins/revolves within the hollow ring torus passing through insulated copper magnet wire windings which are wound around the exterior portion of the ring torus shaped body which, has two or more coils that said sphere magnet passes through forcing electrons through insulated copper coils which, produces electrical current sufficient to power light emitting diodes or a number of low voltage electrical device. Can be encapsulated within a number of devices i.e., flashlight body, fishing lure body or mounted on the axis of a device i.e., spinning fan blade, tire to produce low voltage as the device spins or moves in a rolling motion allowing the sphere magnet to pass through the insulated copper coil windings. | 10-15-2009 |
| 20110154716 | Polar energy air glide fishing swivel - A swivel for connecting a fishing line to fishing lure or other terminal tackle having a main body with one open end and cavity running through the axis of for inserting a coupler into. a rod of which has an eyelet on one end and head on the opposite end which is larger than said rod shaft yet small enough to fit into said main body cavity. two neodymium ring magnets and rubber ring washers which fit onto said rod and are inserted into said main body cavity after which a male compression fitting is inserted into said main body cavity and compressed over ridges on the end cap securing all parts within said main body, the rod shaft spins freely within by using the opposing magnetic poles of the neodymium ring magnets as an air bearing which creates zero friction from moving parts removing any possibility of swivel seizure due to ball bearings wearing out which is common with bearing swivels. | 06-30-2011 |
| 20130162057 | HOLLOW RING TORUS MAGNET GENERATOR - A hollow ring torus permanent magnet generator, with a sphere shaped permanent magnet which spins/revolves within the hollow ring torus passing through insulated copper magnet wire windings wound around the exterior portion of the ring torus shaped body wherein the passing of the sphere shaped permanent magnet through the coil produces electrical current in the insulated copper magnet wire windings. | 06-27-2013 |
| 20140232342 | PORTABLE MOTION ACTIVATED CELL PHONE CHARGER UTILIZING A SHELLED TORUS PERMANENT MAGNET GENERATOR - A portable motion activated cell phone charger utilizing a shelled torus permanent magnet generator to generates electricity by kinetic energy imparted by the user if strapped to the arm or leg when jogging or may also be waved in the hand in an oscillating motion to generate electricity which is stored in a rechargeable battery within the charger assembly of which has a control circuit board with universal serial port attached and accessible from the exterior body casing allowing the user to connect a cell phone or small electronic devices with a universal serial bus cable to power the device or charge a battery within said device. | 08-21-2014 |
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| 20100176918 | Identification and tracking of information stored on radio frequency identification devices - A method and apparatus for detecting and tracking an object within a defined area, and determining its position, status, movement and identity therein, includes interrogating the defined area to communicate with an information device associated with an object and transmit information received to a master controller unit, which determines the object's presence, position, status, movement and identity within the defined area. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or the meaning of the claims. | 07-15-2010 |
| 20110027824 | Method And Apparatus For Analyzing Body Fluids - A system and method for analyzing a specimen containing particles that can be difficult to differentiate. The system and method determines a first collective count of a selected group of particles in the specimen, treats at least a portion of the specimen to alter a subgroup of the selected group of particles, determines a second collective count of any of the selected group of particles in the treated portion of the specimen, and subtracts the second collective count from the first collective count to determine a differentiation count for the subgroup of particles altered by the treating of the specimen. The system and method is described with the example of determining concentrations of red and white blood cells in a specimen (e.g. spinal fluid), using auto-particle recognition techniques, without attempting to distinguish and count red versus white blood cells co-existing in the same specimen portion. | 02-03-2011 |
| 20160042507 | SYSTEM AND METHODS FOR THE IN VITRO DETECTION OF PARTICLES AND SOLUBLE CHEMICAL ENTITIES IN BODY FLUIDS - A system and methods for detecting particles and soluble chemical entities in body fluids consists of a system consisting of a microscopic apparatus, a sample chamber and reagents and methods used to detect, classify and enumerate particles and chemical entities in body fluids. Body fluids containing particles combined with reagents sediment to the bottom of a viewing chamber bringing them into the focal place of a digital microscopic detector. Particles identified as areas within a captured digital image that absorb or emit electromagnetic radiation can be further classified based on additional absorbed or emitted electromagnetic radiation within the predefined areas of the first digital image. Soluble chemical entities in body fluids are detected and concentrations determined using transmitted or emitted electromagnetic radiation using known chemical or antibody reactions, making the microscopic device a general purpose detector for in vitro determinations using body fluids. | 02-11-2016 |
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| 20140309144 | NANOPORE SEQUENCING USING CHARGE BLOCKADE LABELS - The invention relates to devices and methods for nanopore sequencing. The invention includes compositions and methods of nucleic acid sequencing using a single polymerase enzyme complex comprising a polymerase enzyme and a template nucleic acid attached proximal to a nanopore, and nucleotide analogs in solution comprising charge blockade label that are attached to the polyphosphate portion of the nucleotide analog such that the charge blockade labels are cleaved when the nucleotide analog is incorporated into a growing nucleic acid and the charge blockade label is detected by the nanopore to determine the presence and identity of the incorporated nucleotide and thereby determine the sequence of a template nucleic acid. | 10-16-2014 |
| 20140364324 | NANOPORE SEQUENCING USING CHARGE BLOCKADE LABELS - The invention relates to devices and methods for nanopore sequencing. The invention includes compositions and methods of nucleic acid sequencing using a single polymerase enzyme complex comprising a polymerase enzyme and a template nucleic acid attached proximal to a nanopore, and nucleotide analogs in solution comprising charge blockade label that are attached to the polyphosphate portion of the nucleotide analog such that the charge blockade labels are cleaved when the nucleotide analog is incorporated into a growing nucleic acid and the charge blockade label is detected by the nanopore to determine the presence and identity of the incorporated nucleotide and thereby determine the sequence of a template nucleic acid. | 12-11-2014 |
| 20150053641 | PROCESS FOR MAKING HIGH MULTIPLEX ARRAYS - Processes for making high multiplex arrays for use in analyzing discrete reactions at ultra high multiplex with reduced optical noise, and increased system flexibility. The high multiplex arrays include substrates having integrated optical components that increase multiplex capability by one or more of increasing density of reaction regions, improving transmission of light to or collection of light from discrete reactions regions. Integrated optical components include reflective optical elements which re-direct illumination light and light emitted from the discrete regions to more efficiently collect emitted light. Particularly preferred applications include single molecule reaction analysis, such as polymerase mediated template dependent nucleic acid synthesis and sequence determination. | 02-26-2015 |
| 20150072869 | METHODS AND COMPOSITIONS FOR NUCLEIC ACID SAMPLE PREPARATION - The present invention provides methods and compositions useful for supplying high throughput nucleic acid sequencing systems with templates. The methods circumvent the need for costly, labor-intensive cloning and cell culture methods and can be scaled to accommodate template production for a variety of sequencing applications, e.g., sequencing individuals' genomes, sequencing subpopulations of transcripts from a gene of interest, and/or gene expression profiling. Particularly preferred embodiments of the methods vastly improve the preparation of cDNA from mRNA samples, e.g., by randomizing errors introduced during the process, thereby allowing these errors to be readily distinguished from true variants present in the mRNA samples. | 03-12-2015 |
| 20150141266 | SINGLE MOLECULE LOADING METHODS AND COMPOSITIONS - Methods, compositions and arrays for non-random loading of single analyte molecules into array structures are provided. For example, methods are presented for providing a surface comprising the plurality of array regions by exposing the surface to a solution comprising polymerase enzymes where each polymerase enzyme is bound to a binding structure having several functional moieties. The functional moieties of the binding structure react with the binding elements on the array regions such that the functional moieties on the binding structure react with other available binding sites in an array region, preventing other polymerase-binding structures from loading, and resulting in a single polymerase molecule bound to each of these regions. | 05-21-2015 |
| 20150159196 | COMPOSITIONS AND METHODS FOR NUCLEIC ACID SEQUENCING - Compositions and methods for nucleic acid sequencing include template constructs that comprise double stranded portions in a partially or completely contiguous constructs, to provide for redundant sequence determination through one or both of sequencing sense and antisense strands, and iteratively sequencing the entire construct multiple times. Additional sequence components are also optionally included within such template constructs. Methods are also provided for the use and preparation of these constructs as well as sequencing compositions for their application. | 06-11-2015 |
| 20150159213 | NANOPORE SEQUENCING USING N-MERS - The invention relates to devices and methods for nanopore sequencing. The invention provides for using the signals from n-mers to provide sequence information, for example where the system has less than single base resolution. The invention includes arrays of nanopores having incorporated electronic circuits, for example, in CMOS. In some cases, the arrays of nanopores comprise resistive openings for isolating the electronic signals for improved sequencing. Methods for controlling translocation of through the nanopore are disclosed. | 06-11-2015 |
| 20150247800 | Optics Collection and Detection System and Method - Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described. | 09-03-2015 |
| 20150302144 | HIERARCHICAL GENOME ASSEMBLY METHOD USING SINGLE LONG INSERT LIBRARY - The present invention is generally directed to a hierarchical genome assembly process for producing high-quality de novo genome assemblies. The method utilizes a single, long-insert, shotgun DNA library in conjunction with Single Molecule, Real-Time (SMRT®) DNA sequencing, and obviates the need for additional sample preparation and sequencing data sets required for previously described hybrid assembly strategies. Efficient de novo assembly from genomic DNA to a finished genome sequence is demonstrated for several microorganisms using as little as three SMRT® cells, and for bacterial artificial chromosomes (BACs) using sequencing data from just one SMRT® Cell. Part of this new assembly workflow is a new consensus algorithm which takes advantage of SMRT® sequencing primary quality values, to produce a highly accurate de novo genome sequence, exceeding 99.999% (QV 50) accuracy. The methods are typically performed on a computer and comprise an algorithm that constructs sequence alignment graphs from pairwise alignment of sequence reads to a common reference. | 10-22-2015 |
| 20150307934 | INTERMITTENT DETECTION DURING ANALYTICAL REACTIONS - Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period. | 10-29-2015 |
| 20150362503 | REAL-TIME ANALYTICAL METHODS AND SYSTEMS - The present invention is generally directed to compositions, methods, and systems for performing single-molecule, real-time analysis of a variety of different biological reactions, and for determining various characteristics of the different biological reactions. The ability to analyze such reactions provides an opportunity to study those reactions as well as to potentially identify factors and/or approaches for impacting such reactions, e.g., to stimulate, enhance, or inhibit such reactions. | 12-17-2015 |
| 20150376690 | MOLECULAR REDUNDANT SEQUENCING - Methods, systems and compositions where a target nucleic acid includes a registration sequence disposed therein for identification of the number or relative position of determined sequence from the template sequence. Particularly preferred aspects include a registration sequence in a circular template nucleic acid sequence which is, in turn, used in sequence by incorporation processes that rely upon template dependent, polymerase mediated primer extension in the identification of the sequence of the template. | 12-31-2015 |
| 20150376694 | Integrated Analytical System and Method - An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed. | 12-31-2015 |
| 20160061738 | APPARATUS AND METHOD FOR PERFORMING NUCLEIC ACID ANALYSIS - The present invention relates to optical confinements, methods of preparing and methods of using them for analyzing molecules and/or monitoring chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost single-molecular analysis. | 03-03-2016 |
| 20160069806 | Illumination of Integrated Analytical Systems - An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed. | 03-10-2016 |
| 20160083789 | NUCLEIC ACID SEQUENCING WITH NANOSCALE ELECTRODE PAIRS - Sequencing methods, devices, and systems are described. Arrays of nanoscale electronic elements comprising two electrodes separated by an insulating layer are used to provide sequence information about a template nucleic acid in a polymerase-template complex bound proximate to the insulating region. A sequencing reaction mixture comprising nucleotide analogs having impedance labels is introduced to the array of nanoscale electronic elements under conditions of polymerase mediated nucleic acid synthesis. The time sequence of incorporation of nucleotide analogs is determined by identifying the types of labels of the nucleotide analogs that are incorporated into the growing strand using measured impedance. | 03-24-2016 |
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| 20140017690 | MOLECULAR REDUNDANT SEQUENCING - Methods, systems and compositions where a target nucleic acid includes a registration sequence disposed therein for identification of the number or relative position of determined sequence from the template sequence. Particularly preferred aspects include a registration sequence in a circular template nucleic acid sequence which is, in turn, used in sequence by incorporation processes that rely upon template dependent, polymerase mediated primer extension in the identification of the sequence of the template. | 01-16-2014 |
| 20140061048 | NANOPORE SEQUENCING USING N-MERS - The invention relates to devices and methods for nanopore sequencing. The invention provides for using the signals from n-mers to provide sequence information, for example where the system has less than single base resolution. The invention includes arrays of nanopores having incorporated electronic circuits, for example, in CMOS. In some cases, the arrays of nanopores comprise resistive openings for isolating the electronic signals for improved sequencing. Methods for controlling translocation of through the nanopore are disclosed. | 03-06-2014 |
| 20140134610 | COMPOSITIONS AND METHODS FOR SELECTION OF NUCLEIC ACIDS - Methods are provided for reducing the complexity of a population of nucleic acids prior to performing an analysis of the nucleic acids, e.g., sequence analysis. The methods result in a subset of the initial population enriched for a target region, which is typically located within one or more target fragments. The methods are particularly useful for analyzing populations having a high degree of complexity, e.g., chromosomal-derived DNA, whole genomic DNA, or mRNA populations. | 05-15-2014 |
| 20140134629 | INTERMITTENT DETECTION DURING ANALYTICAL REACTIONS - Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period. | 05-15-2014 |
| 20140178863 | SUBSTRATES, SYSTEMS AND METHODS FOR ANALYZING MATERIALS - Substrates, systems and methods for analyzing materials that include waveguide arrays disposed upon or within the substrate such that evanescent fields emanating from the waveguides illuminate materials disposed upon or proximal to the surface of the substrate, permitting analysis of such materials. The substrates, systems and methods are used in a variety of analytical operations, including, inter alia, nucleic acid analysis, including hybridization and sequencing analyses, cellular analyses and other molecular analyses. | 06-26-2014 |
| 20140179564 | COMPOSITIONS AND METHODS FOR SELECTION OF NUCLEIC ACIDS CONTAINING MODIFIED BASES - Methods are provided for reducing the complexity of a population of nucleic acids prior to performing an analysis of the nucleic acids, e.g., sequence analysis. The methods result in a subset of the initial population enriched for a desired property, or lacking nucleic acids having an undesired property. The methods are particularly useful for analyzing populations having a high degree of complexity, e.g., chromosomal-derived DNA, whole genomic DNA, or mRNA populations. In addition, such methods allow for analysis of pooled samples. | 06-26-2014 |
| 20140199016 | Illumination of Optical Analytical Devices - Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include optical waveguides for illumination of the optical reactions. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices of the invention are well suited for miniaturization and high throughput. | 07-17-2014 |
| 20140287964 | INTEGRATED ILLUMINATION OF OPTICAL ANALYTICAL DEVICES - Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include integrated illumination elements and optical waveguides for illumination of the optical reactions. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices of the invention are well suited for miniaturization and high throughput. | 09-25-2014 |
| 20140315756 | Articles Having Localized Molecules Disposed Thereon and Methods of Producing Same - Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate. | 10-23-2014 |
| 20150065353 | REAL-TIME ELECTRONIC SEQUENCING - Real time electronic sequencing methods, devices, and systems are described. Arrays of nanoscale electronic elements comprising capacitive devices with one or two electrodes, or arrays of nanoFET devices are used to provide sequence information about a template nucleic acid in a polymerase-template complex bound proximate to the nanoscale electronic elements or to the substrate proximate to the nanoscale electronic element. A sequencing reaction mixture comprising nucleotide analogs having impedance labels, capacitive labels, or conductivity labels is introduced to the array of nanoscale electronic elements comprising capacitive devices or nanoFETs under conditions of polymerase mediated nucleic acid synthesis. The time sequence of incorporation of nucleotide analogs is determined by identifying the types of labels of the nucleotide analogs that are incorporated into the growing strand using measured impedance, conductivity, or capacitance. | 03-05-2015 |
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| 20100049827 | SYSTEM AND METHOD FOR AGGREGATING AND PROVIDING AUDIO AND VISUAL PRESENTATIONS VIA A COMPUTER NETWORK - A method for providing content via a computer network and computing device, which may include: storing data associated with and indicative of a plurality of presentations; receiving a request to host an audio presentation; receiving and storing data associated with the requested audio presentation; initiating and recording one or more telephone calls; and, presenting at least a portion of the stored data for selection by the computing device; wherein, selection causes the stored data indicative of the selected audio/visual or audio presentation to be provided to the computing device for playback thereby via the computer network. The method may include storing data associated with and indicative of a first plurality of presentations; storing data associated with a plurality of second presentation feeds: automatically and periodically accessing each of the feeds; and aggregating each of the presentations for delivery via the computer network. | 02-25-2010 |
| 20100050096 | SYSTEM AND METHOD FOR PROVIDING AND TRACKING THE PROVISION OF AUDIO AND VISUAL PRESENTATIONS VIA A COMPUTER NETWORK - A method for tracking digital media presentations: providing a corresponding web page for each digital media presentation to be delivered; providing identifier data to the user's computer; providing a timer applet to the user's computer; and, storing data indicative of received identifier data; wherein each provided webpage causes corresponding digital media presentation data to be streamed from a second computer system distinct from a first computer system directly to the user's computer independent of the first computer system; and stored data is indicative of an amount of time the digital media presentation data is streamed from the second computer system to the user's computer. | 02-25-2010 |
| 20100050098 | CONTENT, TRAFFIC AND ADVERTISING ENGINE, SYSTEM AND METHOD - An engine, platform, system and method of interconnecting content generation, advertisement relevance, and traffic stimulation. The present invention may include the generation of one or more content items into a primary content window, the presentation of one or more content items in a secondary content window, a repeated crawl of the one or more content items in the primary content window, the presentation of a first plurality of advertisements relevant to the repeated crawl, the maintenance of a viewer of the primary content window at least partially based upon the one or more content items in the secondary content window, at least until the presentation of a second plurality of advertisements relevant to the repeated crawl, a targeting of at least one subset of traffic in accordance with the generation of the content in the primary content window, and a tracker that increases proportionally with the relevance of the first plurality of advertisements. | 02-25-2010 |
| 20100115042 | SYSTEM AND METHOD FOR ENHANCING DIGITAL CONTENT - A computer-readable medium including computer-executable code for enhancing an electronic document with one link and being served via a network responsively to a request received via the network and correspondent to an electronic document. The chat application may be for use with a mobile device and be less computing resource intensive. Certain embodiments of the present invention may not require a code or applets to be inserted to provide chat functionality. Advantageously, only a link may need to be inserted, for example. This may provide particularly well suited for use with websites where traditional chat code or applets may not be inserted. | 05-06-2010 |
| 20100165888 | SYSTEM AND METHOD FOR INITIATING A CONFERENCE CALL - The present invention is a system and method for initiating conference calls via an instant messaging system to reduce the effort required to initiate and manage the call. The system uses an IM connection between a requesting party and a conference call server to inform the conference call server of the desire to initiate the conference call. The conference call server may initiate the conference call by having involved parties called by a conference bridge, thus reducing the effort required by the parties to join the call. | 07-01-2010 |
| 20110033035 | SYSTEM AND METHOD FOR INITIATING A CONFERENCE CALL - The present invention is a system and method for initiating conference calls via an instant messaging system to reduce the effort required to initiate and manage the call. The system uses an IM connection between a requesting party and a conference call server to inform the conference call server of the desire to initiate the conference call. The conference call server may initiate the conference call by having involved parties called by a conference bridge, thus reducing the effort required by the parties to join the call. | 02-10-2011 |
| 20110161440 | SYSTEM AND METHOD FOR ENHANCING DIGITAL CONTENT - A computer program product being tangibly embodied in a computer-readable medium and including computer-executable code for enhancing an electronic document including a plurality of advertisements, the computer program product computer-executable code including: code for receiving a request corresponding to an identifier associated with a given advertisement responsively to a user's interaction with the electronic document; and code for launching a clientless chat application that corresponds to the advertisement responsively to the receiving, regardless of whether the electronic document allows chat-application code to be embedded therein. | 06-30-2011 |
| 20120188330 | SYSTEM AND METHOD FOR INITIATING A CONFERENCE CALL - The present invention is a system and method for initiating conference calls via an instant messaging system to reduce the effort required to initiate and manage the call. The system uses an IM connection between a requesting party and a conference call server to inform the conference call server of the desire to initiate the conference call. The conference call server may initiate the conference call by having involved parties called by a conference bridge, thus reducing the effort required by the parties to join the call. | 07-26-2012 |
| 20130144962 | System and Method for Enhancing Digital Content - A computer-readable medium including computer-executable code for enhancing an electronic document with one link and being served via a network responsively to a request received via the network and correspondent to an electronic document. The chat application may be for use with a mobile device and be less computing resource intensive. Certain embodiments of the present invention may not require a code or applets to be inserted to provide chat functionality. Advantageously, only a link may need to be inserted, for example. This may provide particularly well suited for use with websites where traditional chat code or applets may not be inserted. | 06-06-2013 |
| 20140119525 | SYSTEM AND METHOD FOR INITIATING A CONFERENCE CALL - The present invention is a system and method for initiating conference calls via an instant messaging system to reduce the effort required to initiate and manage the call. The system uses an TM connection between a requesting party and a conference call server to inform the conference call server of the desire to initiate the conference call. The conference call server may initiate the conference call by having involved parties called by a conference bridge, thus reducing the effort required by the parties to join the call. | 05-01-2014 |
| 20140164576 | SYSTEM AND METHOD FOR AGGREGATING AND PROVIDING AUDIO AND VISUAL PRESENTATIONS VIA A COMPUTER NETWORK - A method for providing content via a computer network and computing device, which may include: storing data associated with and indicative of a plurality of presentations; receiving a request to host an audio presentation; receiving and storing data associated with the requested audio presentation; initiating and recording one or more telephone calls; and, presenting at least a portion of the stored data for selection by the computing device; wherein, selection causes the stored data indicative of the selected audio/visual or audio presentation to be provided to the computing device for playback thereby via the computer network. The method may include storing data associated with and indicative of a first plurality of presentations; storing data associated with a plurality of second presentation feeds: automatically and periodically accessing each of the feeds; and aggregating each of the presentations for delivery via the computer network. | 06-12-2014 |
| 20140297378 | CONTENT, TRAFFIC AND ADVERTISING ENGINE, SYSTEM AND METHOD - An engine, platform, system and method of interconnecting content generation, advertisement relevance, and traffic stimulation. The present invention may include the generation of one or more content items into a primary content window, the presentation of one or more content items in a secondary content window, a repeated crawl of the one or more content items in the primary content window, the presentation of a first plurality of advertisements relevant to the repeated crawl, the maintenance of a viewer of the primary content window at least partially based upon the one or more content items in the secondary content window, at least until the presentation of a second plurality of advertisements relevant to the repeated crawl, a targeting of at least one subset of traffic in accordance with the generation of the content in the primary content window, and a tracker that increases proportionally with the relevance of the first plurality of advertisements. | 10-02-2014 |
