Patent application number | Description | Published |
20100189669 | Regulation of Mammalian Keratinous Tissue Using Skin and/or Hair Care Actives - Personal care compositions containing an active selected from the group consisting of phlorogine, phlorgine BG, deoxyArbutin, sucrose dilaurate, bakuchiol, pyrenoine, millet, arlatone dioic acid, cinnamic acid, ferulic acid, achromaxyl, methyl nicotinamide, oil soluble licorice extract, folic acid, undecylenic acid, zinc undecylenate, L-tryptophan, thiamine HCl, hexylresorcinol, lipidami red vine, dragosine, methyl gentisate, inositol, symdiol 68, laminaine, their salts, their derivatives, their precursors, and/or combinations thereof. Methods for regulating the condition of mammalian keratinous tissue by topically applying the personal care compositions are also provided. | 07-29-2010 |
20110097286 | COMPOSITIONS AND METHODS FOR INHIBITING PAR2 ACTIVATION OF KERATINOCYTES - A composition for inhibiting PAR2 activation of keratinocytes is disclosed as comprising a vitamin B3 compound, an N-acyl amino acid compound, and a | 04-28-2011 |
20120148510 | Compositions and Methods for Improving the Appearance of Facial Pores - A method of improving the appearance of facial pores is provided. The method includes the step of applying a composition having an effective amount of a material that regulates IL-1 and/or hyaluronic acid synthesis to an area of facial pores, wherein the composition is applied for a period of time sufficient for the material to improve the appearance of the facial pores. In some embodiments, the material that regulates IL-1 and/or hyaluronic acid synthesis is hexyldecanol. The method may also include the step of identifying facial pores on a facial skin surface. | 06-14-2012 |
20120148515 | Cosmetic Compositions and Methods for Inhibiting or Reducing Trypsin Activity - A cosmetic composition formulated for topical application to skin is provided. The composition includes a safe and effective amount of cyclohexane-1,2,3,4,5,6-hexyl; a safe and effective amount of an N-acyl amino acid compound; and a dematologically acceptable vehicle. | 06-14-2012 |
20120156146 | Compositions and Methods for Improving the Appearance of Facial Texture - A method of improving the appearance of facial texture may comprise the step of applying a composition comprising an effective amount of a material that regulates hyaluronic acid synthesis to an area of textured facial skin, wherein the composition is applied for a period of time sufficient for the material to improve the appearance of the facial texture. In some embodiments, the material that regulates hyaluronic acid synthesis is hexyldecanol. The method may also include the step of identifying facial texture on a facial skin surface. In particular embodiments, the facial skin texture is selected from the group consisting of macro-texture, micro-texture, and combinations thereof. | 06-21-2012 |
20120197016 | SCREENING METHODS OF MODULATING ADRENERGIC RECEPTOR GENE EXPRESSIONS IMPLICATED IN MELANOGENESIS - Embodiments of screening methods for determining test agents effective for modifying the appearance of pigmented skin are provided. The screening method may comprise the steps of contacting a cell, a cell culture, or bulk cells with the test agent, wherein the cell, the cell culture, or the bulk cells comprise ADRβ1 receptors, and determining based on the binding interaction of the test agent with the ADRβ1 receptors whether the test agent is an effective ADRβ1 receptor antagonist suitable for modifying the appearance of pigmented skin, wherein a test agent is considered to be an effective ADRβ1 receptor antagonist when it defines a half maximal inhibitory concentration of less than about 1000 ppm. | 08-02-2012 |
20120201768 | COSMETIC COMPOSITIONS COMPRISING FICUS SERUM FRACTION AND METHODS TO REDUCE THE APPEARANCE OF SKIN HYPERPIGMENTATION - The present invention provides cosmetic compositions comprising | 08-09-2012 |
20130022557 | Methods For Improving the Appearance of Hyperpigmented Spot(s) Using an Extract of Laminaria Saccharina - A method of improving the appearance of a hyperpigmented spot may comprise the step of applying a composition comprising a safe and effective amount of an | 01-24-2013 |
20130022558 | Methods For Imrproving the Appearance of Hyperpigmented Spot(s) and Skin Tone - A method of improving the appearance of a hyperpigmented spot and improving skin tone may comprise the steps of applying a safe and effective amount of a | 01-24-2013 |
20130022559 | Methods For Inhibiting Tyrosinase Using an Extract of Laminaria Saccharina - A method of inhibiting tyrosinase activity may involve the step of applying a composition comprising a | 01-24-2013 |
20130259816 | Method of Formulating a Skin-Lightening Composition - A method of formulating a skin-lightening composition by identifying actives with a data architecture and incorporating the actives into a skin care composition. The data architecture can be used to identify connections between perturbagens and genes associated with skin tone. A gene expression profile for a control human cell is compared to the gene expression profile a cell exposed to perturbagen to identify the genes which are differentially expressed. The differentially expressed genes are analyzed and arranged into an ordered list of identifiers, which along with other instances create a data architecture. | 10-03-2013 |
20130261006 | Method of Generating a Hyperpigmentation Condition Gene Expression Signature - A method of generating a hyperpigmentation condition gene expression signature for use in identifying connections between perturbagens and genes associated with a skin pigmentation condition. The method includes providing a gene expression profile for a reference sample of human skin cells not affected with a pigmentation condition; generating a gene expression profile for a sample of human skin cells from a subject exhibiting the hyperpigmentation condition; comparing the expression profiles to determine a gene expression signature that includes a set of differentially expressed genes; assigning an identifier to each gene constituting the gene expression signature and ordering the identifiers according to the direction of differential expression to create one or more gene expression signature lists; and storing the one or more gene expression signature lists on at least one computer readable medium. | 10-03-2013 |
20130261007 | Method of Constructing a Data Structure - A method of constructing a data architecture for use in identifying connections between perturbagens and genes associated with skin tone. The method includes providing a gene expression profile for a control cell, generating a gene expression profile for a cell exposed to a perturbagen, identifying genes differentially expressed in response to the perturbagen, creating an ordered list of identifiers, storing the ordered list as an instance on a computer readable medium, and constructing a data architecture of stored instances. | 10-03-2013 |
20130261024 | System for Identifying Connections Between Perturbagens and Genes Associated with a Skin Hyperpigmentation Condition - A system for identifying connections between perturbagens and genes associated with a skin hyperpigmentation condition. The system includes a computer readable medium having a plurality of instances stored thereon, and a skin hyperpigmentation-relevant gene expression signature. Each instance includes an instance list of rank-ordered identifiers of differentially expressed genes, and the hyperpigmentation-relevant gene expression signature includes a gene expression signature list of identifiers representing differentially expressed genes associated with a hyperpigmentation condition or differentially expressed genes associated with a benchmark skin-lightening agent. The system also includes a programmable computer with computer-readable instructions that allow the computer to accessing the instances and a hyperpigmentation-relevant gene expression signature stored on the computer readable medium, comparing the hyperpigmentation-relevant gene expression signature to the plurality of the instances, and/or assigning a connectivity score to each of the plurality of instances. | 10-03-2013 |
20140271506 | Cosmetic Compositions and Methods For Inhibiting Melanin Synthesis - A cosmetic composition suitable for topical application, for example, is provided. In some examples, the cosmetic composition may include undecylenoyl phenylalanine, hexyldecanol, and bisabolol. A method of reducing the synthesis of melanin by using said cosmetic compositions is also disclosed herein. | 09-18-2014 |
20140328775 | Cosmetic Compositions and Methods For Inhibiting Melanin Synthesis - A cosmetic composition suitable for topical application, for example, is provided. In some examples, the cosmetic composition may include batyl alcohol, undecylenoyl phenylalanine, hexyldecanol, and bisabolol. A method of reducing the synthesis of melanin by using the cosmetic compositions is also disclosed herein. | 11-06-2014 |