Tomaino
Barbara Tomaino, Rivarolo Canavese IT
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20100028907 | Novel Antigens and Antibodies Associated to Pancreatic Ductal Adenocarcinoma - The present invention provides novel human protein antigens and related antibodies that have been identified as being specifically expressed in association to human Pancreatic Ductal Adenocarcinoma (PDA). In particular, novel phosphorylated isoforms of alpha-enolase have been identified in transformed cell lines of pancreatic origin and antibodies binding such isoforms are specifically present in the sera of PDA patients. These proteins and antibodies can be useful for the diagnosis and the treatment of PDA and other cancers having common molecular features. | 02-04-2010 |
Barbara Tomaino, Rivarolo Canavese (torino) IT
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20120164146 | ISOLATED MONOPHOSPHORYLATED PEPTIDE DERIVED FROM HUMAN ALPHA-ENOLASE USEFUL FOR DIAGNOSIS AND TREATMENT OF PANCREATIC ADENOCARCINOMA, ANTIBODIES DIRECTED AGAINST THE SAID MONOPHOSPHORYLATED PEPTIDE, AND USES THEREOF - An isolated peptide of 12-20 amino acids in length comprising the amino acid sequence SEQ ID NO:1, wherein the serine residue (S) at position 8 of SEQ ID NO:1 is phosphorylated, is provided. Also provided is a human monophosphorylated alpha-enolase isoform wherein the serine residue (S) at position 419 of the human alpha-enolase amino acid sequence (SEQ ID NO:2) is phosphorylated and in which other post-translational modifications may be present. Further provided are antibodies capable of specifically binding the peptide and/or the isoform of the invention. The peptide, the isoform and the antibodies of the invention may be used in the diagnosis and/or amelioration and/or treatment of pancreatic adenocarcinoma. | 06-28-2012 |
John Tomaino, Allenhurst, NJ US
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20110100183 | Table saw blade height and angle adjustment mechanism - A mechanism for automatically adjusting the height and angle of a table saw blade is disclosed. The table saw comprises a working surface through which the saw blade protrudes to a certain height. An arbor assembly is connected to the bottom of the working surface of the table saw by means of pivot shoes. The mechanism adjustment disclosed comprises two motors and shafts coupled to the arbor assembly that allows the user to adjust the height and angle of the saw blade independently as required for the dimension of the material to be cut or the desired angle of the cut. | 05-05-2011 |
Matthew M. Tomaino, Rochester, NY US
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20100069966 | Bone Plate System for Hand Fractures and Other Small Bones - A bone plate system for the internal fixation of metacarpal and phalanx fractures of the hand is provided. The plates are structured to permit independent reconfiguration of holes of the plates relative to a longitudinal axis and are configured to orient fasteners to interdigitate with holes displaced along the longitudinal axis. The plates are very thin, and a locking screw with a low profile head design is provided for use therewith. | 03-18-2010 |