Tilman
Tilman Achstetter, Bremen DE
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20100112634 | YEAST STRAINS AUTONOMOUSLY PRODUCING STEROIDS - The present invention relates to genetically modified yeast strains autonomously producing, from a simple carbon source, steroids. The invention also relates to a method for producing steroids from such yeast strains. | 05-06-2010 |
20110104749 | MODIFIED YEASTS AND USES THEREOF, IN PARTICULAR FOR PRODUCING STEROID DERIVATIVES - The present invention relates to novel yeast strains, methods and genetic constructs for their preparation, and their use for the synthesis or modification of steroidal compounds. More particularly, the invention describes strains having a reduced 20αHSD type activity, in particular by modifying the GCY1 and/or YPR1 genes. The yeast strains of the invention make it possible to improve the efficiency of the synthesis or to increase the selectivity or the yields of the method, as well as the quality of the final product. The strains, methods and compounds of the invention are useful in the search for, the development and the production of products with therapeutic or prophylactic activity, in humans or animals, in particular of steroidal derivatives. | 05-05-2011 |
Tilman Bohnengel, Bammental DE
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20110145187 | CONFLICT FRAMEWORK FOR GUIDED STRUCTURE SYNCHRONIZATION - A system and method for handling conflicts during structure synchronization. Conflicts are identified as the structure moves through the synchronization process. An intermediate structure is generated on a format of a target structure. A proposal for resolution of the identified conflicts is created. The conflicts and proposed resolutions are presented to a user. Proposals accepted by the user are applied to the intermediate structure. | 06-16-2011 |
Tilman Bohnengel, Schoenau DE
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20140173632 | Typed Access of Business Object Data Structures - A service request is received to execute an operation on a business object. Thereafter, the business object is associated with one of a plurality of business object access classes that in turn comprise methods, types, and constants to execute the operation on the business object. The business object is then called using the associated business object access class to respond to the service request. Related apparatus, systems, techniques and articles are also described. | 06-19-2014 |
Tilman Diesselhorst, Munchen DE
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20120039018 | Device for Discharging an Explosive Gas - A device for releasing an explosive gas via a stack arranged on a roof of a building is provided. The upper free end of the stack is provided with a discharging head including a plurality of distribution pipes projecting from the stack in the form of a star. Each pipe includes an outlet on the free end thereof. The device reduces the pressure wave load exerted during an explosion even during adverse wind conditions. To this end, the end regions of the distribution pipes are embodied as jet pumps in which the explosive gas is the propellant sucking the ambient air. | 02-16-2012 |
Tilman Ebding, Weil Am Rhein DE
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20150254425 | HANDWRITING RECOGNITION TOOL - Some implementations may provide a method implemented on a processor, the method includes: receiving, on a computer host, an electronic document representing a pharmaceutical prescription; identifying constituent regions that include at least a first portion and a second portion within the electronic document; identifying first spatial frequencies for the first portion within the electronic document; identifying second spatial frequencies for the second portion within the electronic document; identifying a header based upon the first spatial frequencies; using the header to identify a prescriber; retrieving a profile for the prescriber; analyzing the second spatial frequencies using the profile for the prescriber; and creating, based upon analyzing the second spatial frequencies using the profile for the prescriber, a transaction record on the computer host for a medical transaction associated with the pharmaceutical prescription. | 09-10-2015 |
Tilman Felgentreff, Holzkirchen DE
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20150145602 | Broadband RF Power Amplifier with Active Load Modulation - An apparatus includes a main amplifier core and auxiliary amplifier core(s), an input signal splitter connected to inputs of the main amplifier core and the auxiliary amplifier core(s), and an output combiner connected to outputs of the main amplifier core and an the auxiliary amplifier core(s). The input signal splitter is configured to split an input signal into a first signal for the main amplifier core and at second signal(s) for the auxiliary amplifier core(s) according to frequency dependent nonlinear input drive functions. The output combiner is configured to combine output signals of the main amplifier core and the auxiliary amplifier core(s), and to provide a continuum of optimum termination impedances of the main amplifier core for the fundamental frequency and at least one harmonic frequency over a predetermined bandwidth of operation, in a low power region. The low power region is defined by the auxiliary amplifier core(s) being inactive. | 05-28-2015 |
Tilman Hanstein, Cologne DE
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20090243616 | MULTI-COMPONENT MARINE ELECTROMAGNETIC SIGNAL ACQUISITION METHOD - A method for determining a component of electric field response of the Earth's subsurface to a time-varying electromagnetic field induced in the Earth's subsurface is provided. The method includes measuring electric field response along a nonlinear pattern on at least one of the Earth's surface and the bottom of a body of water. The method includes measuring magnetic field response in three directions along the nonlinear pattern on at least one of the Earth's surface and the bottom of the body of water. The method further includes determining an electric field response in a direction normal to the measured electric field response using the electric field response and magnetic field response measurements. | 10-01-2009 |
Tilman Hoefelmayr, Niederteufen CH
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20090211528 | Device For Stimulating An Udder During Milking - The invention relates to a device for stimulating an udder during milking, comprising a housing with a first connection ( | 08-27-2009 |
20110193342 | HOSE COUPLING - The invention discloses a hose coupling ( | 08-11-2011 |
20110283810 | Apparatus and method for measuring a quantity of milk yielded by an animal during a milking process - An apparatus for measuring a quantity of milk yielded by an animal during a milking process comprises a container, a supply unit, a discharge unit, a filling level measuring device, a control unit and an evaluation unit. The supply unit is configured to feed milk into the container and can be connected to the milking unit of a milking machine. The discharge unit is configured to discharge milk from the container and can be connected to the milking line of the milking machine, which is adapted to have applied thereto a milking vacuum. The discharge unit comprises the means for changing the size of a discharge opening through which the milk flows when it is being discharged from the container. The discharge opening allowing milk to flow through the discharge opening can be adjusted to at least two sizes. The filling level measuring device is configured to measure a filling level of the milk in the container. The control unit is configured to control the means for changing the size of the discharge opening in dependence on the milk level in the container determined by the filling level measuring device, in order to adjust a size of the discharge opening such that the filling level remains within a predetermined range. The evaluation unit is configured to calculate a milk flow into the container on the basis of the set size of the discharge opening and of the filling level measured by the filling level measuring device. | 11-24-2011 |
20140174598 | DEVICE FOR CARRYING OUT AT LEAST ONE MEASUREMENT AND FOR TAKING MILK SAMPLES FROM A MILKING MACHINE - The invention relates to a device for carrying out at least one measurement and for removing milk samples from a milking machine, through which milk can flow and which comprises an air separation device, a measurement device, a sample removal device and a channel that is open to the top. According to the invention, the air separation device is designed to separate the milk from air with which the milk is mixed. The measurement device is arranged downstream of the air separation device. It is connected to the air separation device by a first milk outlet opening of the air separation device and designed to carry out one or more measurements with the milk flowing through the device. The sample removal device is designed to supply milk to a sample container. The channel open to the top is arranged upstream of the measurement device and is designed to receive at least a part of the milk which was separated from the air with which said milk was mixed in the air separation device and to direct said milk so that it flows at least partially to the sample removal device. | 06-26-2014 |
20150150211 | DEVICE FOR STIMULATING AN UDDER DURING MILKING - The invention relates to a device for stimulating an udder during milking, made up of a housing with a first connection ( | 06-04-2015 |
Tilman Kluver, Oslo NO
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20090185444 | Method for wavefield separation in 3D dual sensor towed streamer data with aliased energy in cross-streamer direction - Pressure records and vertical particle velocity records from dual sensor towed streamer data are transformed to the inline wavenumber domain. A series of scaling filters are applied to the transformed vertical particle velocity records at each inline wavenumber, wherein each of the series of scaling filters is calculated for a different cross-streamer wavenumber range and in blocks of inline traces in which all seismic events are approximately linear. The pressure spectrum and the scaled vertical particle velocity spectrum are combined to separate upgoing and downgoing wavefield components. The separated upgoing and downgoing wavefield components are inverse-transformed back to the time-space domain. | 07-23-2009 |
20100182873 | Method for wavefield separation for dual-sensor data using kirchhoff-type datuming and migration - A first weighted integral operator is applied to dual-sensor data to extrapolate the dual-sensor data to a first position above an acquisition surface, generating extrapolated data. A second weighted integral operator is applied to the extrapolated data to extrapolate the extrapolated data to a second position, generating wavefield separated data. One of the integral operators is applied to a scaled combination of the dual sensor data. | 07-22-2010 |
20100286920 | Method for calculation of seismic attributes from seismic signals - Filters are applied to seismic signals representative of subsurface formations to generate filtered signals with attenuated spatially aliased energy. The filtered signals are multiplied in the frequency-wavenumber domain by a complex function of frequency and wavenumber representing the seismic attribute in the frequency-wavenumber domain, to generate scaled signals. The scaled signals, transformed to the time-space domain, are divided by the filtered signals in the time-space domain, to a seismic attribute useful for identifying and characterizing the subsurface formations. | 11-11-2010 |
Tilman Klüver, Sande NO
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20110063948 | Method for combining signals of pressure and particle motion sensors in marine seismic streamers - A cross-line slowness is determined for each sample in the signals in towed marine seismic streamers. A range of assumed cross-line slownesses is selected. Vertical wavenumbers are determined using the range of assumed cross-line slowness determined for samples in the signals of pressure sensors and particle motion sensors in the towed marine seismic streamers. The determined vertical wavenumbers are used to correct the particle motion sensor signals for angle of incidence along the direction of the seismic streamers and transverse thereto to generate a corrected particle motion sensor signal. The corrected particle motion sensor signals are combined based on the determined cross-line slowness for the samples. The corrected particle motion sensor signal and the pressure sensor signal are used to determine at least one of upgoing and downgoing pressure components and upgoing and downgoing particle motion components of the particle motion sensor and pressure sensor seismic signals. | 03-17-2011 |
Tilman Klüver, Sande NO
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20100124148 | Method for optimum combination of pressure and particle motion sensors for a 3-D spread of dual-sensor marine seismic streamers - A method for determining upgoing pressure components of seismic signals from signals detected by combined pressure responsive sensors and motion responsive seismic sensors disposed in a plurality of laterally spaced apart streamers includes determining a threshold time at which angle of incidence error in the motion responsive signals in the cross-line direction falls below a selected threshold. Below the threshold time, the motion responsive signals are corrected for angle of incidence in the in-line and cross-line directions. Above the threshold time, the motion responsive signals are corrected for angle of incidence only in the in-line direction. Both sets of incidence corrected measured motion responsive signals, and the pressure responsive signals are used to determine upgoing or downgoing pressure components or upgoing or downgoing motion components of the measured motion responsive and pressure responsive seismic signals. | 05-20-2010 |
20110063948 | Method for combining signals of pressure and particle motion sensors in marine seismic streamers - A cross-line slowness is determined for each sample in the signals in towed marine seismic streamers. A range of assumed cross-line slownesses is selected. Vertical wavenumbers are determined using the range of assumed cross-line slowness determined for samples in the signals of pressure sensors and particle motion sensors in the towed marine seismic streamers. The determined vertical wavenumbers are used to correct the particle motion sensor signals for angle of incidence along the direction of the seismic streamers and transverse thereto to generate a corrected particle motion sensor signal. The corrected particle motion sensor signals are combined based on the determined cross-line slowness for the samples. The corrected particle motion sensor signal and the pressure sensor signal are used to determine at least one of upgoing and downgoing pressure components and upgoing and downgoing particle motion components of the particle motion sensor and pressure sensor seismic signals. | 03-17-2011 |
20140269183 | SYSTEMS AND METHODS FOR FREQUENCY-DOMAIN FILTERING AND SPACE-TIME DOMAIN DISCRIMINATION OF SEISMIC DATA - Computational systems and methods that combine global frequency-wavenumber-domain (“f-k domain”) filters with localized eigenimage based event selection to generate a resulting wavefield with reduced filter imprints on gather edges, reduced noise, and correct treatment of aliased energy are disclosed. The methods are executed by applying filters to the full set of seismic gather data in the f-k domain in order to obtain a resulting wavefield from recorded pressure and/or particle velocity data. The output of the filter is iteratively decomposed according to local dip values using eigenimage processing based on singular value decomposition (“SVD”). The same sample locations are extracted using SVD from the input in addition to generating input for a subsequent iteration with already processed data removed. Eigenimage processing methods allow for correct treatment of spatially aliased energy in f-k domain filtering. | 09-18-2014 |
20140340987 | NOISE MODELS BY SELECTION OF TRANSFORM COEFFICIENTS - A data set representing features of a geologic formation is formed from two or more signal acquisition data set representing independent aspects of the same wavefield. A wavelet transform is performed on the two or more signal acquisition data sets, and the data sets are further transformed to equalize signal portions of the data sets. Remaining differences in the data sets are interpreted as excess noise and are removed by different methods to improve the signal-to-noise ratio of any resulting data set. | 11-20-2014 |
Tilman Koch, Uttenreuth DE
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20110051986 | Magnetic System for an Electroacoustic Transducer - A magnetic system for an electroacoustic transducer, including an annular magnet which provides a magnetic field for a moving coil. The magnetic system has a first magnetic element forming a base plate and at least one second magnetic element forming a cover plate. The annular magnet is arranged between the first and second magnetic element. The annular magnet is held by the magnetic forces acting between the first magnetic element and the magnet, or between the magnet and the second magnetic element. | 03-03-2011 |
Tilman Laeppchen, Eindhoven NL
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20130272959 | AGENTS FOR CLEARING BIOMOLECULES FROM CIRCULATION - Described is a method, and a combination of agents for used therein, by which an agent administered to a subject can be rapidly cleared from circulation. This is achieved by providing an Administration Agent (e.g. a probe for pretargeting) with a reactive group and providing a Clearing Agent with another reactive group, said reactive groups forming a bio-orthogonally reactive pair. Preferably, the reactive pair comprises a cyclooctene or cyclooctyn as one reactant, and a diene as the other reactant. The method and combination can be used for the removal of any bindable molecule from circulation, such as an excess of a pre-targeting probe in the course of a pre-targeting method, a targeting or imaging agent delivered, or the removal of any biomolecule already present in circulation. | 10-17-2013 |
Tilman Lappchen, Eindhoven NL
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20150147273 | RADIOLABELED ANALOG(S) OF COMPOUND 0118 AND USE THEREOF IN CONNECTION WITH PET AND/OR SPECT IMAGING TO DETERMINE WHETHER A PHARMACEUTICAL CONTAINING COMPOUND 0118 IS A CANDIDATE CANCER TREATMENT FOR A PATIENT - A method for determining whether compound 0118 is a candidate treatment for a patient includes processing, via a processor, image data of tissue of interest of a patient including a cancer to determine whether a radiolabeled analog of compound 0118 is present in the tissue of interest represented in the image data and generating a signal indicating that compound 0118 is a candidate treatment for the patient in response to the determining that the radiolabeled analog of compound 0118 is present in a predetermined amount in the tissue of interest represented in the image data, wherein the presence of the radiolabeled analog of compound 0118 in the tissue of interest indicates presence of a sub-type of cancer having a galectin-1 molecular target, which is a sub-type of treatable by compound 0118. | 05-28-2015 |
Tilman Miehle, Waiblingen DE
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20100288233 | FUEL METERING UNIT FOR A FUEL METERING UNIT FOR A HIGH-PRESSURE FUEL PUMP, AND HIGH-PRESSURE FUEL PUMP - The invention relates to a fuel metering device for regulating the delivery rate of a high-pressure fuel pump of a fuel injection device for an internal combustion engine. The fuel metering device has a control valve actuated by an electromagnet and having a valve member. The electromagnet has an armature and an armature rod and the armature rod is axially movably supported in at least one bushing. The at least one bushing is designed as a solid, one-piece metal component. The bushing is preferably made of steel and the bearing surface thereof, in which the armature rod is supported, has a nitrocarburized and polished surface layer. | 11-18-2010 |
20120152208 | FUEL METERING DEVICE FOR A FUEL INJECTION SYSTEM - The present invention relates to a fuel metering device for a fuel injection system for internal combustion engines having a plastic housing. According to the invention, the fuel metering device includes a control valve having a valve piston which is actuated by an actuating device. Furthermore, the plastic housing can be produced by spray-coating. | 06-21-2012 |
20120168018 | PLUG CONNECTION - The invention provides a plug connector for media-bearing lines. The plug connector has a plug body for connecting to an opening. At least one rib is provided on the plug body, the rib being retained in the opening in the assembly position of the plug body by a retaining clip adjustable on the plug body. An assembly force acts on the retaining clip, the clip being supported on at least one rib of the plug body, thereby displacing the plug body into the opening, and locking therein in an undercut. | 07-05-2012 |
20120222759 | NON-RETURN VALVE HAVING TWO CLOSING BODIES - In a non-return valve having a first closing body and a related first valve seat, and a second closing body and a related second valve seat, according to the invention the first and second valve seats are designed on a single valve seat component and the second valve seat is designed so as to surround the outside of the first valve seat. | 09-06-2012 |
20130270949 | PERMANENT MAGNET ELECTRIC MACHINE WITH TWO PART OR MULTI PART PERMANENT MAGNETS - A permanent magnet electric machine ( | 10-17-2013 |
Tilman Naeher, Wiggensbach DE
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20150019005 | PACKAGING LINE - The present invention relates to a packaging line comprising a packaging machine and at least one additional component, wherein the packaging machine and the component each have an at least partially local control and the packaging line has a line regulation/control. The present invention further relates to a method for operating a packaging line comprising a packaging machine and at least one additional component, wherein the packaging machine and each component have an at least partially local control and the packaging line has a line regulation/control. | 01-15-2015 |
Tilman Niederfuehr, Freiburg DE
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20140059771 | TABLE ADAPTER WITH JOINT ASSEMBLY - A table adapter and joint assembly are configured for use with a table during a medical procedure, e.g. a medical imaging procedure or combined imaging and surgical procedure. The table adapter is connectable, directly or indirectly, to a portion of the table. The joint assembly connects with the table adapter about a shaft such that the joint assembly is rotatably adjustable. A head fixation device in the form of a skull clamp is attachable to the joint assembly. The joint assembly generally has a parallelogram shape that has four joints for adjustment where these four joints can be selectively locked or unlocked relative to each other using a single actuator. | 03-06-2014 |
Tilman Oltersdorf, Cardiff, CA US
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20100168135 | Method of Inducing Cleavage of Amyloid Precursor Protein to Form a Novel Fragment - The present invention provides a method of inducing cleavage of amyloid precursor protein to produce an approximately 17 kilodalton carboxy-terminal fragment of amyloid precursor protein in a subject, the method comprising administering a heterocyclic compound or a pharmaceutically acceptable salt, hydrate or prodrug thereof to a subject in need thereof, wherein the approximately 17 kilodalton fragment includes the carboxyterminal amino acid sequence of amyloid precursor protein and amyloid-beta amino acid sequence. Also provided is a screening method for identifying compounds induce cleavage of amyloid precursor protein to produce the approximately 17 kilodalton carboxy-terminal fragment of amyloid precursor protein. | 07-01-2010 |
20100298348 | Method of Decreasing Ubiquitylated Protein Levels - The present invention provides a method of decreasing the level of ubiquitylated protein in a subject, the method comprising administering a heterocyclic compound disclosed herein or a pharmaceutically acceptable salt, hydrate or prodrug thereof to a subject in need thereof. | 11-25-2010 |
Tilman Reutter, Eidenberg AT
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20090119894 | APPARATUS FOR NEEDLING A NON-WOVEN WEB - An apparatus for needling a non-woven web. The apparatus comprises at least one needle beam. The needle beam, the lower side of which comprises a needle board having a plurality of needles, is held by a beam support, which is guided by means of a vertical drive for an oscillating movement in an upward and downward movement and is guided by means of a horizontal drive for an oscillating movement in a reciprocating movement. At least two driven eccentric shafts and several connecting rods, which are assigned to the eccentric shafts and the free ends of which are coupled to the beam support, are provided as the vertical drive. The horizontal drive comprises at least one horizontal link, one end of which is connected to the beam support and the opposite end of which is coupled to a gear kinematics, which comprises an eccentric drive. In order to achieve the simplest and most compact possible design of the horizontal drive, the gear kinematics is formed according to the invention by a rocker, one end of which is held on a machine frame by means of a frame swivel joint and the opposite end of which comprises a double swivel joint, said rocker being coupled at the double swivel joint to the horizontal link and the eccentric drive. | 05-14-2009 |
20100242240 | DEVICE FOR NEEDLING A NONWOVEN WEB - The invention relates to a device for needling a nonwoven web having on the base thereof at least one needle bar comprising a needle board having a plurality of needles. The needle bar is held by a bar carrier on which a vertical drive engages for oscillating motion of the bar carrier for an up and down movement. A superimposed horizontal drive is also associated with the bar carrier, by which a back-and-forth movement is induced. The horizontal drive has two eccentric drives coupled to a horizontal guide. The eccentric drives are each formed by a connecting rod and a crankshaft coupled to a connecting head of the connecting rod. According to the invention, the connecting rods are coupled to the horizontal guide with the connecting rod ends thereof in a diagonal orientation, the center axes of the connecting rods forming an angle. | 09-30-2010 |
20100306978 | DEVICE FOR NEEDLING A FIBROUS WEB - The invention relates to a device for needling a fibrous web having at least one needle bar. The needle bar carries a needle board on the bottom thereof having a plurality of needles, the needle bar being guided by means of a moveably mounted bar carrier. The bar carrier is driven by a vertical drive in an oscillating manner in up and down movements. For straight guidance of the bar carrier, a guiding device is provided, which has at least one rocker held at the end by a rotary bearing of a machine frame. In order to obtain the straightest possible guide path in the bar carrier, according to the invention the opposite end of the rocker and the bar carrier are connected by a plurality of members of a coupling kinematic mechanism. | 12-09-2010 |
20110047767 | DEVICE FOR NEEDLING A WEB OF FIBER - The invention relates to a device for needling a web of fiber, said device comprising at least one driven needle beam. A vertical reciprocal movement of the needle beam is carried out by a vertical drive unit and a superposed horizontal reciprocal movement is carried out by a horizontal drive unit or due to a phase adjustment by the vertical drive unit. A weight balancing device is provided for balancing the inertia forces of the crank mechanisms. In order to be able to balance both vertical and horizontal inertia forces in a simple manner, the weight balancing device is formed by at least one balance weight which is asso ciated with the crank mechanism of the vertical drive unit and which is set-off by an angle in the range of <180° from an eccentric element of the crank mechanism. | 03-03-2011 |
20110179611 | APPARATUS FOR NEEDLING A FIBROUS WEB - An apparatus is described for needling a fibrous web having at least one needle bar. On its underside, the needle bar carries a needle board with a multiplicity of needles, wherein the needle bar is guided via a movably held bar carrier. The bar carrier is driven in an oscillating manner with a superimposed horizontal and vertical movement by a crank mechanism drive. To this end, a phase shifting device is provided, by which the crankshafts of the crank mechanism drive can be adjusted depending on the phase relation. Here, the movement of the bar carrier is guided by a guide device. In order to obtain stable guidance with high flexibility in every situation, according to the invention the guide device is formed by a steering rod which is connected at one end to the bar carrier by a rotary joint and which is coupled with the other end to a steering gear by a second rotary joint. | 07-28-2011 |
20120174357 | DEVICE FOR NEEDLING A FIBROUS WEB - The invention relates to a device for needling a fibrous web having at least one needle bar. The needle bar carries a needle board on the bottom thereof having a plurality of needles, the needle bar being guided by means of a moveably mounted bar carrier. The bar carrier is driven by a vertical drive in an oscillating manner in up and down movements. For straight guidance of the bar carrier, a guiding device is provided, which has at least one rocker held at the end by a rotary bearing of a machine frame. In order to obtain the straightest possible guide path in the bar carrier, according to the invention the opposite end of the rocker and the bar carrier are connected by a plurality of members of a coupling kinematic mechanism. | 07-12-2012 |
Tilman Richers, Frankfurt Am Main DE
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20140301857 | DEVICE AND METHOD FOR MANUFACTURING A COMPONENT - The invention relates to a device ( | 10-09-2014 |
20150224721 | APPARATUS AND METHOD FOR PRODUCING A ROTOR BLADE SPAR CAP - An apparatus and method for producing a rotor blade spar cap for a rotor blade of a wind turbine. The apparatus includes a mold, which has a cavity-like depression in cross section, in which material for a rotor blade spar cap can be placed, and a sheet-like mold covering for sealing off the depression. The depression has side walls, an opening bounded by the side walls and a base area between the side walls. In accordance with the method, fiber material and/or fiber-reinforced material is placed in the depression of the mold such that the material finishes flush with the side walls with respect to the height of the rotor blade spar cap, the depression is sealed off by the sheet-like mold covering, the material is fused together to form the rotor blade spar cap and the rotor blade spar cap is removed from the mold. | 08-13-2015 |
Tilman Roedle, Wolfegg DE
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20110282295 | SYRINGE - A syringe includes a syringe cylinder and a distal end designed as a syringe cone. The distal end comprises a region set back in a radial direction such that an edge extending in the circumferential direction is formed. The edge has a first chamfer, and comprises an attachment piece having a clamping region. Holding forces are introduced from the attachment piece via the clamping region in the region of the syringe set back in a radial direction. The clamping region comprises a distal edge. The the distal edge of the clamping region has a second chamfer. | 11-17-2011 |
20130338575 | CLOSURE PIECE FOR A POWDER SYRINGE, AND POWDER SYRINGE - A closure piece for a powder syringe has a main body and a sealing element. The sealing element is disposed on the main body such that it rests in a sealing manner against a distal opening of a powder syringe when the closure piece is disposed in the closing position thereof on the powder syringe. A channel passes through the main body and the sealing element and has a proximal and a distal end. The closure piece includes a retaining element configured and/or disposed such that, prior to an activation of the powder syringe, any powder from a chamber of the powder syringe is at least substantially prevented from penetrating the channel when the closure piece is disposed in the closing position thereof on the powder syringe. | 12-19-2013 |
20130338603 | CLOSURE FOR A SYRINGE AND METHOD OF PRODUCING SAME - A syringe has a syringe cylinder and a needle attachment piece provided at a distal end thereof of the syringe cylinder. The syringe has a closure including a closure cap that closes off the needle attachment piece, forming a seal, and a securing cap. The securing cap surrounds the closure cap and is attached to the needle attachment piece by way of a holding ring. At least the securing cap and the closure cap are configured in one piece. | 12-19-2013 |
20130338604 | CLOSURE AND METHOD FOR PRODUCING A CLOSURE - A closure for a syringe or carpule includes a main body and a sealing element for engaging in a sealing manner with an opening of the syringe or carpule when the closure is arranged in its sealing position on the syringe or carpule. The closure is embodied in a single piece. | 12-19-2013 |
20140158700 | CONTAINER, HOLDING DEVICE, HOLDING SYSTEM AND INJECTION AID - A container for pharmaceutical preparations includes a base body. The container has at least one first holding means embodied such that it can work together with a corresponding second holding means of a holding device for the container in order to hold the base body securely on the holding device. | 06-12-2014 |
Tilman Ruegheimer, Regensburg DE
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20140085169 | Display Device - A display device includes a multiplicity of pixels, at least one connection carrier, and a multiplicity of inorganic light-emitting diode chips. The connection carrier includes a multiplicity of switches. Each pixel contains at least one light-emitting diode chip. Each light-emitting diode chip is mechanically fixed and electrically connected to the connection carrier. Each switch is designed for driving at least one light-emitting diode chip and the light-emitting diode chips are imaging elements of the display device. | 03-27-2014 |
Tilman Sanchez-Elsner, Southampton GB
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20150079118 | MicroRNA Treatment for Asthma - This invention relates to a composition for modifying the activity of microRNA-mediated regulation of mRNA in a cell, wherein the composition comprises: two or more compounds capable of blocking two or more microRNA molecules from binding to the same target mRNA, wherein the two or more microRNA molecules are different in sequence or structure relative to each other. In particular, compositions for use in the treatment of asthma and methods of prevention or treatment of asthma. | 03-19-2015 |
Tilman Schneider-Hohendorf, Muenster DE
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20140315188 | ASSESSMENT OF PML RISK AND METHODS BASED THEREON - The invention provides a method of assessing the risk of occurrence of progressive multifocal leukoencephalopathy (PML) in a subject as well as a method of stratifying a subject undergoing α | 10-23-2014 |
20150105278 | METHODS OR RISK ASSESSMENT OF PML AND RELATED APPARATUS - The invention provides a method of assessing the risk of occurrence of progressive multifocal leukoencephalopathy (PML) in a subject as well as a method of stratifying a subject undergoing VLA-4 blocking agent treatment for suspension of VLA-4 blocking agent treatment. These methods comprise detecting the level of L-selectin (CD62L) and optionally LFA-1 expressing T cells in a sample from the subject. | 04-16-2015 |
Tilman Schneider-Poetsch, Erftstadt DE
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20110053994 | POTENT IMMUNOSUPPRESSIVE AGENTS, DERIVATIVES AND USES - Provided herein include compositions, all related stereoisomers as well as pharmaceutically acceptable salts provided as simplified analogs of pateamine A, in which the analogs generally are devoid of the C3-amino and C5-methyl groups, also referred to as desmethyl, desamino-pateamine A. Suitable analogs provide anticancer and antiproliferative effects in vivo and in vitro by a novel drugs mechanism of action described herein for pateamine A, including inhibition of eIF4A-dependent translation initiation. As with pateamine A, as described herein, suitable analogs cause cell cycle arrest or induce apoptosis in transformed cells. However, toxicity of such compounds to slow growing normal cells is low. In addition, such analogs, like pateamine A, target translation initiation factors and are useful as anticancer and antiproliferative agents in subjects in need thereof. Moreover, the analogs, like pateamine A, are valuable molecular probes for evalutaion of eukaryotic translation initiation and as lead compounds for development of improved anticancer agents. | 03-03-2011 |
Tilman Sirch, Schifferstadt DE
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20080207958 | Method For Production Of 1,6-Hexanediol With A Purity In Excess of 99.5% - The present invention provides a process for preparing 1,6-hexanediol by hydrogenating dialkyl adipates, alkyl 6-hydroxycaproates, 1,4-cyclohexanedione and 4-hydroxycyclohexan-1-one as ester mixtures comprising impurities, by | 08-28-2008 |
20090069604 | PROCESS FOR HYDROGENATING METHYLOLALKANALS - A process for catalytically hydrogenating methylolalkanals of the general formula | 03-12-2009 |
20100113836 | METHOD FOR PRODUCING HYDROXY PIVALIN ALDEHYDE AND NEOPENTYL GLYCOL - The preparation of hydroxypivalaldehyde is effected by aldolizing isobutyraldehyde with formaldehyde and subsequently working up the resulting reaction effluent by distillation, wherein the reaction effluent is fed to a distillation column which is operated at a top pressure in the range from 0.5 to 1.5 bar and in which a two-stage condensation is provided in the top region, in which the vapors are first conducted into a partial condenser operated at a temperature in the range from 50 to 80° C., whose condensate is recycled at least partly into the distillation column, and in which the vapors uncondensed in the partial condenser are fed to a downstream condenser operated at a temperature in the range from −40 to +30° C., whose condensate is at least partly discharged. | 05-06-2010 |
20100168445 | PROCESS FOR PREPARING EPSILON-CAPROLACTONE - The present invention provides a process for preparing ε-caprolactone in a purity above 99%, in which 6-hydroxycaproic ester comprising from 0.5 to 40% by weight of adipic diester is cyclized in the gas phase at from 150 to 450° C. in the presence of oxidic catalysts and ε-caprolactone is obtained from the cyclization product by distillation. | 07-01-2010 |
20100240913 | PROCESS FOR PREPARING EPSILON-CAPROLACTONE - The present invention provides a process for preparing ε-caprolactone in a purity of more than 99% by cyclizing 6-hydroxycaproic esters in the liquid phase at from 150 to 400° C. and from 1 to 1020 hPa abs., and removing and condensing the compounds which are volatile under cyclization conditions, which comprises thermally treating the remaining bottom product of the cyclization in at least one further reactor, removing and condensing volatile compounds and obtaining ε-caprolactone by distillation from the condensates. | 09-23-2010 |
20110015429 | PROCESS FOR PREPARING 6-HYDROXYCAPROIC ESTERS - The present application relates to an improved process for preparing 6-hydroxycaproic esters from the by-product mixtures which are obtained in the oxidation of cyclohexane to cyclohexanol and cyclohexanone with oxygen or oxygen-comprising gas mixtures. | 01-20-2011 |
20110272270 | Process for Preparing Polymethylols - The present invention relates to a process for recovering components from a low boiler mixture which is obtained in the distillation of hydrogenation effluents from the preparation of polymethylols, by multistage distillation of the low boiler mixture comprising a tertiary amine, water, methanol, polymethylol of the formula (I) | 11-10-2011 |
20110313203 | METHOD FOR PURIFYING CRUDE POLYMETHYLOLS - The present invention relates to a process for purifying crude polymethylol which comprises polymethylol of the formula (I) | 12-22-2011 |
20110313207 | PROCESS FOR DISTILLATIVE WORKUP OF A METHANOL/WATER MIXTURE AND PROCESS FOR PREPARING ALKALI METAL METHOXIDES - The invention relates to a process for distillative workup of a methanol/water mixture, in which a methanol/water mixture is added to a distillation column ( | 12-22-2011 |
20120004472 | METHOD FOR PREPARING POLYMETHYLOLS - The present invention relates to a process for distilling an aqueous polymethylol mixture which comprises a polymethylol of the formula (I) | 01-05-2012 |
20120035399 | METHOD FOR PRODUCING 1,6-HEXANEDIOL BY HYDROGENATION OF OLIGO- AND POLYESTERS - The present invention relates to a process for hydrogenating oligo- and/or polyesters obtainable by esterifying a DCS with a diol or diol mixture, said hydrogenation being performed in the presence of a catalyst whose catalyst precursor comprises copper oxide, aluminum oxide and at least one oxide of lanthanum, of iron, of tungsten, of molybdenum, of titanium or of zirconium, and to a process for preparing 1,6-hexanediol by catalytically hydrogenating ester mixtures which comprise, as main components, oligo- and polyesters of adipic acid and 6-hydroxycaproic acid, and are obtained by esterifying DCS with diols, especially 1,6-hexanediol or diol mixtures. | 02-09-2012 |
Tilman Spellig, Dortmund DE
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20090075328 | PROCESS FOR THE OVEREXPRESSION OF DEHYDROGENASES - A process for the overexpression of dehydrogenases, especially for the overexpression of Δ | 03-19-2009 |
Tilman Sporkert, Cupertino, CA US
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20140007074 | METHODS FOR UPDATING APPLICATIONS | 01-02-2014 |
20140007075 | METHODS FOR UPDATING APPLICATIONS | 01-02-2014 |
Tilman Staeblein, Wuerzburg DE
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20130333795 | CONCENTRATE CONTAINER HAVING SUPPORTING ELEMENTS - The invention relates to a container for dialysis concentrates, in particular acidic dry concentrates. When these dry concentrates are dissolved directly by the dialysis machine to form liquid concentrates, the containers must provide a volume of 4-12 liters. To impart the required stability to these containers, they have integral supporting elements, which manifest their supporting function only when the container is used on the dialysis machine. | 12-19-2013 |
Tilman Thrum, Richmond CA
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20100276611 | HIGH-INTENSITY ELECTROMAGNETIC RADIATION APPARATUS AND METHODS - An apparatus for producing electromagnetic radiation includes a flow generator configured to generate a flow of liquid along an inside surface of an envelope, first and second electrodes configured to generate an electrical arc within the envelope to produce the electromagnetic radiation, and an exhaust chamber extending outwardly beyond one of the electrodes, configured to accommodate a portion of the flow of liquid. In another aspect, the flow generator is electrically insulated. In another aspect, the electrodes are configured to generate an electrical discharge pulse to produce an irradiance flash, and the apparatus includes a removal device configured to remove particulate contamination from the liquid, the particulate contamination being released during the flash and being different than that released by the electrodes during continuous operation. | 11-04-2010 |
Tilman Von Blumenthal, Lubeck DE
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20100139659 | SPO2 CONTROL WITH ADAPTIVE LINEAR COMPENSATION - A device and a process for controlling a respirator with inclusion of an oxygen saturation value ( | 06-10-2010 |
20100224189 | PROCESS FOR OPERATING A RESPIRATOR - A process for controlling a respirator with reduced gas excess, wherein a load situation ( | 09-09-2010 |
20100269829 | SLOT VALVE FOR USE IN THE PNEUMATIC SWITCHING CIRCUIT OF A RESPIRATOR - A slot valve ( | 10-28-2010 |
20130139817 | OXYGEN REGULATION WITH AT LEAST TWO SPO2 MONITORS AND AUTOMATIC RECOGNITION OF A SIGNAL HAVING A HIGHER RATING - A process and a device for oxygen regulation of a patient having at least two SPO | 06-06-2013 |
Tilman Zipplies, Burghausen DE
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20100113679 | METHOD OF MAKING FLUOROPOLYMER DISPERSION - A method of making a fluoropolymer dispersion by first providing a fluoropolymer dispersion comprising fluoropolymer particles and one or more fluorinated surfactants selected from fluorinated carboxylic acids or salts thereof having the general formula: | 05-06-2010 |
20110245520 | METHOD OF MAKING FLUORINATED ALKOXY CARBOXYLIC ACIDS AND PRECURSORS THEREOF - A method for preparing saturated partially fluorinated alkoxy carboxylic acids or salts thereof by treating a compound: (II), where R | 10-06-2011 |
20120252949 | METHOD OF MAKING FLUOROPOLYMER DISPERSION - A method of making a fluoropolymer dispersion by first providing a fluoropolymer dispersion comprising fluoropolymer particles and one or more fluorinated surfactants selected from fluorinated carboxylic acids or salts thereof having the general formula: | 10-04-2012 |