Thomas, MA
Ajith Thomas, Brookline, MA US
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20140239600 | METHODS AND DEVICES FOR SAFELY PENETRATING MATERIALS - The present invention is directed to a bi-stable coupling for controlling the depth of a tool insertion, such as drilling, and similar processes. The bi-stable coupling can be used to penetrate (e.g., drill or push) through a material layer of unknown thickness without plunging the tool into the adjacent layer. In accordance with the invention, in a first state, force is applied to the tool to initiate penetration and a reactive force maintains the device in the first state during penetration and when tool penetrates the material, the reactive force is diminished enabling the device to transition to a second state in which the tool becomes retracted. In medical applications, the invention allows for drilling through bone of unknown thickness without plunging into the adjacent soft tissue. | 08-28-2014 |
Amanda Thomas, Watertown, MA US
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20120083487 | COMBINATION OF MORPHINAN COMPOUNDS AND ANTIDEPRESSANT FOR THE TREATMENT OF PSEUDOBULBAR AFFECT, NEUROLGICAL DISEASES, INTRACTABLE AND CHRONIC PAIN AND BRAIN INJURY - Provided herein are compositions comprising a dextromethorphan analog according to Formula I or Formula II or a pharmaceutically acceptable salt thereof of either of the foregoing, and a co-agent, e.g., an antidepressant such as a serotonin norepinephrine reuptake inhibitor; a serotonin noradrenaline dopamine reuptake inhibitor; a norepinephrine dopamine reuptake inhibitor; a monoamine oxidase inhibitor; a selective serotonin reuptake inhibitor; and a tricyclic antidepressant or a pharmaceutically acceptable salt of any of the foregoing. The compositions are useful in the treatment of pseudobulbar affect, neuropathic pain, neurodegenerative diseases, brain injuries, and the like. | 04-05-2012 |
Amelia H. Thomas, Medford, MA US
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20110293685 | SCAFFOLDS FOR TISSUE ENGINEERING AND REGENERATIVE MEDICINE - The methods and compositions described herein relate to novel 3-dimensional porous scaffolds useful for tissue re-generation, enhancement, or tissue repair. Electrospinning or other methods are used to create mats comprised of fibers that can be seeded with cells and subsequently rolled into a desired shape/form to replace a desired tissue. | 12-01-2011 |
Andrew Thomas, Arlington, MA US
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20110204959 | Charge Pump with Reduced Current Variation - Circuits and methods for maintaining a substantially constant input and output current for a charge pump circuit are provided which reduce current variation during switching intervals. The charge pump circuitry of the present invention maintains a current flow path from a current source to the charge pump output which minimizes or eliminates spikes normally associated with the switching intervals. | 08-25-2011 |
Andrew Thomas, Westford, MA US
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20090045994 | MULTIPLE MODE DIGITIZATION SYSTEM FOR A NON-DESTRUCTIVE INSPECTION INSTRUMENT - A multiple mode digitization system for a non-destructive inspection instrument which makes use of a multiplexing circuit and a single set of analog to digital converters to efficiently digitize analog test signals from a plurality of inputs. In the preferred embodiment, each of the analog to digital converters in the system is driven with an independent and separate clock signal, allowing for propagation delay compensation among the plurality of test signals as well as interleaved sampling such that custom sampling rates can be used for each input without the need for more than one clock frequency. In an alternate embodiment, phase adjustments on the sampling clocks are used only for interleave sampling, and digital filters are used to provide signal propagation delay compensation. | 02-19-2009 |
20090205428 | ULTRASONIC DETECTION MEASUREMENT SYSTEM USING A TUNABLE DIGITAL FILTER WITH 4X INTERPOLATOR - An ultrasonic inspection system utilizes a tunable digital filter with 4× interpolation. The system is used for scanning objects to be tested and includes a transmit/receive device to generate a test signal and receive an echo signal. A signal processing circuit processes the echo signal with one or more digital to analog converters for converting an analog version of the echo signal to a digital echo signal in the form of streaming digital data which is stored in a memory. The data is stored at a first data rate and read out at the second, slower data rate. An averaging decimator receives and processes the data from the memory and supplies it to an IIR filter and subsequently to an FIR filter and ultimately to a box car filter to effect processing thereon which increases the perceived resolution of the data by a given factor, preferably by a factor of 4. | 08-20-2009 |
20100147081 | EXTENDED OVERFLOW INDICATION FOR HIGH DYNAMIC RANGE ULTRASONIC FAULT DETECTION SYSTEMS - A method and apparatus for effecting ultrasonic flaw detection of an object processes an echo signal received from the object being tested in at least three signal channels, wherein the echo signal is scaled to different degrees along each channel to increase and extend the dynamic range of an associated A/D converter system, in a manner which dispenses with the need for using numerous analog high pass and low pass filters and a variable gain amplifier. This reduces complexity and avoids performance limitations. The digital to analog converters sample the differently scaled input signal and a selection circuit selects the output of the digital output obtained from that analog to digital converter which has the highest gain, but which has not overflowed. The digital outputs are seamlessly merged to produce an output that can be displayed as a scan display which shows the location of faults. | 06-17-2010 |
20110126624 | SEQUENTIALLY FIRED HIGH DYNAMIC RANGE NDT/NDI INSPECTION DEVICE - An apparatus for performing ultrasonic inspection of an object, during one measurement on the object, triggers a sequence of excitations of the probe system and receives a sequence of substantially identical echo signals reflected from the object, and further scales each echo signal to different degrees to increase and extend the dynamic range of the echo signals. An A/D converter is then used to digitize the scaled signal sequentially in a manner which dispenses the need for using numerous A/D converters and the associated filters. The digitized signal samples are then combined to produce a single digital output in a manner that is not over-flowed and with desirable resolution. | 06-02-2011 |
20110132092 | HIGH DYNAMIC RANGE NDT/NDI INSPECTION DEVICE WITH SELECTIVE NOISE AVERAGING - An apparatus for performing ultrasonic inspection of an object, during one measurement on the object, triggers a sequence of excitations of the probe system and receives a sequence of substantially identical echo signals reflected from the object, and further scales each echo signal to different degrees to increase and extend the dynamic range of the echo signals. An A/D converter is then used to digitize the scaled signal sequentially in a manner which dispenses the need for using numerous A/D converters and the associated filters. The digitized signal samples are then combined to produce a single digital output in a manner that is not over-flowed and with desirable resolution. A sequence of successive acquisitions of the scaled signal with the highest sensitivity are averaged to reduce system noise. | 06-09-2011 |
20130030726 | CIRCUITRY FOR MEASURING AND COMPENSATING PHASE AND AMPLITUDE DIFFERENCES IN NDT/NDI OPERATION - Disclosed are a method and an NDT/NDI inspection device deploying digital circuitry to conduct detection and compensation of phase and amplitude shift in responding signals. A digital waveform generator, such as a direct digital synthesizer (DDS) is used to generate a digital sine-wave of a specific frequency and amplitude, mimicking the pulser frequency and amplitude. The sine-wave is converted to analog signal through a DAC and transmitted to the transducer. The received analog sine-wave from the transducer is converted back to a digital signal through an ADC. The transmitted and received digital signals are then compared for phase and amplitude differences. A null circuit involving another waveform generating component is employed to compensate the detected phase and amplitude differences. As a result the phase and amplitude differences are effectively eliminated before being further processed and analyzed for defects information. | 01-31-2013 |
20130255386 | APPARATUS FOR AND A METHOD OF IMPROVED TIMING CONTROL FOR NON-DESTRUCTIVE TESTING AND INSPECTION - A pulse generation circuit and method includes using digital signals to trigger a first and second varying analog signals and detecting when they reach one or more reference levels. In response to the first and second varying analog signals reaching one or more reference levels, a first and a second digital control signals are produced and provided as input to a pulser producing a voltage excitation pulse having a width and timing defined by the first and second digital control signals. | 10-03-2013 |
20130257415 | CIRCUITRY FOR AND A METHOD OF COMPENSATING DRIFT IN RESISTANCE IN EDDY CURRENT PROBES - Disclosed is an eddy current non-destructive inspection device which includes an eddy current probe with a probe conductor resistance dynamically changing due to operation conditions, such as temperature. The device further includes a signal generating circuit generating an inspection frequency signal and a low frequency signal. Sensed inspection frequency signals are processed to produce resulting signals with possible drift. A low frequency processing circuit includes a resistance calculator producing a substantially true value of the dynamic probe resistance, based on which compensation operations are configured to correct the drifted resulting signals and produce corrected resulting signals. | 10-03-2013 |
20140132254 | HALL EFFECT MEASUREMENT INSTRUMENT WITH TEMPERATURE COMPENSATION - Disclosed is a Hall Effect instrument with the capability of compensating for temperature drift consistently, accurately and in real time of operation. The instrument embodies a four-point ohm meter circuit measuring Hall Effect sensor resistance and tracking the effect of temperature on the Hall Effect sensor. The instrument takes into account a relationship between the temperature and a temperature compensation index on a per probe basis, which has exhibited a deterministic difference observed by the present inventor. | 05-15-2014 |
20140338454 | APPARATUS FOR AND A METHOD OF IMPROVED TIMING CONTROL FOR NON-DESTRUCTIVE TESTING AND INSPECTION - A pulse generation circuit and method includes using digital signals to trigger a first and second varying analog signals and detecting when they reach one or more reference levels. In response to the first and second varying analog signals reaching one or more reference levels, a first and a second digital control signals are produced and provided as input to a pulser producing a voltage excitation pulse having a width and timing defined by the first and second digital control signals. | 11-20-2014 |
20150085143 | METHOD AND CIRCUITRY FOR REMOVING CIRCLING DRIFTS IN NDT/NDI MEASUREMENT DISPLAY - Disclosed is a method and an apparatus for removing circling drifts on the display of the measured eddy current or other continuous waves. The circling dot which is supposed to be a static dot can obscure information required by the operator to judge if a small defect is present. Embodiments of presently disclosed harmonic rejection filters are tunable and employed to effectively abate or eliminate signals with frequencies that are multiples of operating frequencies, resulting in the removal of the circling effects on the display. | 03-26-2015 |
20150142356 | HALL EFFECT MEASUREMENT INSTRUMENT WITH TEMPERATURE COMPENSATION - Disclosed is a Hall Effect instrument with the capability of compensating for temperature drift consistently, accurately and in real time of operation. The instrument embodies a four-point ohmmeter circuit measuring Hall Effect sensor resistance and tracking the effect of temperature on the Hall Effect sensor. The instrument takes into account a relationship between the temperature and a temperature compensation index on a per probe basis, which has exhibited a deterministic difference observed by the present inventor. | 05-21-2015 |
20150212184 | PACKET BASED DDS MINIMIZING MATHEMATICAL AND DAC NOISE - Disclosed are a method of and an apparatus devising a packet based DDS circuitry for performing packet based a direct digital synthesizing (DDS) function within an electronic testing instrument. The circuitry comprising a DDS logic circuit configured to execute direct digital syntheses on a plurality of consecutive packets of sine-like waves, each packet having a length of a period precisely chosen such that the sine wave at the end of one packet matches up with the sine wave at the start of the immediate subsequent packet. Also disclosed is an eddy current testing circuitry using multiple outputs of the single packet based DDS, one of the output is used in a circuit producing reference signals approximating the response signals. With the usage of the packet based DDS, the reference signal can be highly effective in nulling the unchanging portion of the response signals. | 07-30-2015 |
Andrew J. Thomas, Arlington, MA US
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20090121912 | Circuits and methods to reduce or eliminate signal-dependent modulation of a reference bias - Circuits and methods that improve the performance of voltage reference driver circuits and associated analog to digital converters are provided. A voltage reference driver circuit that maintains a substantially constant output voltage when a load current is modulated by an input signal is provided. The voltage reference driver circuit synchronously decouples a voltage regulation circuit from the load circuit when modulating events such as pulses caused by the load circuit during a switching interval are generated, preventing disturbance of the regulation circuitry and keeping its output voltage substantially constant. | 05-14-2009 |
20110187573 | TIME-MULTIPLEXED RESIDUE AMPLIFIER - A system is configured and a method is provided for receiving an input ratio represented by a first input signal and a second input signal, and producing an output ratio represented by a first output signal and a second output signal. The system is constructed and the method is provided for alternately operating in at least two time periods, wherein in one time period the first input signal, a low accuracy amplifier, and the first output signal are selectively coupled, and in another time period the input signal, the low accuracy amplifier, a high accuracy attenuator, and the second output signal are selectively coupled so as to maintain the output ratio proportional to the input ratio. | 08-04-2011 |
Andrew Joseph Thomas, Arlington, MA US
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20100271245 | COMPLEX-ADMITTANCE DIGITAL-TO-ANALOG CONVERTER - A circuit includes a digital-to-analog converter configured to produce an analog output signal (1) proportional to a reference signal and (2) as a function of a digital input signal. The converter comprises a plurality of non-trivially complex admittances configured so that each non-trivially complex admittance can be selectively switched as a function of the digital input signal so as to be coupled between a reference terminal configured to receive a reference signal and an output terminal. The method comprises selectively switching non-trivially complex admittances as a function of the digital signal between a reference terminal and an output terminal. | 10-28-2010 |
20150295588 | SUPPRESSING DIELECTRIC ABSORPTION EFFECTS IN SAMPLE-AND-HOLD SYSTEMS - Sample-and-hold (S/H) circuitry operating in track and hold phases and having a first S/H circuit with a first hold capacitor at which a first voltage value is maintained in the hold phase, and a dielectric absorption (DA)-suppressing circuit connectable to the first hold capacitor for operating the S/H circuitry in an additional phase after completing the hold phase and before entering the track phase. The DA-suppressing circuit is configured to supply the first hold capacitor, during an operation in the additional phase, with a second voltage value that is negatively correlated with the first voltage value. | 10-15-2015 |
Andrew R. Thomas, Westford, MA US
Andrew Robert Thomas, Westford, MA US
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20100103016 | SAMPLE ERROR MINIMIZATION FOR HIGH DYNAMIC RANGE DIGITIZATION SYSTEMS - A blending circuit is disclosed to be operable to combine plurality of digital outputs received from an analog to digital conversion system to create a composite digital signal. The analog to digital conversion system receives analog signals originated from multiple but substantially the same source signals, wherein the source signals being scaled to different degrees. A blending circuit deploys a blending factor to combine the digital outputs in a manner which blends and/or adjusts portion of each digital output being used to avoid over-flown portion of the digital outputs and to minimize phase and/or amplitude discontinuity of the composite digital signal. | 04-29-2010 |
Appu Naveen George Thomas, Beverly, MA US
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20110226739 | PROCESS CHAMBER LINER WITH APERTURES FOR PARTICLE CONTAINMENT - An apparatus for use within a process chamber is provided. The apparatus includes a liner adapted to cover the sidewalls of the process chamber, with apertures corresponding to various inlets and outlets in the process chamber. In addition, the liner has one or more apertures on its bottom surface, which allow particles to pass through the liner. The liner is designed to be shorter in height than the sidewalls of the process chamber. This allows the liner to be placed within the chamber such that its bottom surface is above the floor of the process chamber. This minimizes the possibility of particles that have fallen onto the process chamber floor becoming re-suspended at a later time. According to a second aspect of the disclosure, a bottom liner is provided. This liner can be used in conjunction with a conventional liner or in a process chamber without a liner. | 09-22-2011 |
April L. Thomas, Marshfield, MA US
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20090299671 | INTELLIGENT SATURATION CONTROL FOR COMPOUND SPECIFIC OPTIMIZATION OF MRM - Mass spectrometer parameters used to tune a mass spectrometer for multiple reaction monitoring (MRM) are determined from a single injection of a sample. Two or more precursor ion scans and a plurality of product ion scans for each precursor ion scan are performed from the injection. Each precursor ion scan is produced with different mass spectrometer parameters that create a different level of ion current. The mass spectra of the precursor ion scans are analyzed to determine if saturation has occurred in any of the precursor ion scans. A precursor ion scan that produces the highest ion current with the least amount of saturation is selected. The mass spectrometer parameters used to tune the mass spectrometer for MRM are determined from (1) the mass spectrometer parameters of the selected precursor ion scan and (2) the mass spectrometer parameters of product ion scans from fragments of the selected precursor ion scan. | 12-03-2009 |
Arthur H. Thomas, Chelmsford, MA US
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20100064179 | Call-stack pattern matching for problem resolution within software - A method of diagnosing a fault condition within software can include, responsive to a fault condition within a computing system belonging to an organization, automatically sending call-stack information for the fault condition to a first server within the organization. Within the first server, the call-stack information for the fault condition can be compared with call-stack information from prior fault conditions that occurred within the organization to determine whether the call-stack information for the fault condition matches call-stack information from one of the prior fault conditions. The method further can include sending the call-stack information to a second server for comparison with call-stack information from prior fault conditions that occurred within at least one different organization if the call-stack information for the fault condition does not match. | 03-11-2010 |
Ben Thomas, Cambridge, MA US
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20130191341 | METHODS AND APPARATUS FOR RESTORING A USER-SELECTED SUBSET OF APPLICATION DATA - In some embodiments, an apparatus includes a backup module configured to receive, from a compute device, a copy of user data associated with a user and generated at the compute device. The backup module is configured to store the copy of user data in a storage device. The backup module is configured to provide a user interface for the user to access the copy of user data. The backup module is configured to receive, from a user device associated with the user, an indication of a subset of the copy of user data. The backup module is configured to, in response to the indication, retrieve the subset of the copy of user data from the storage device and send the subset of the copy of user data to the compute device such that the subset of the copy of user data is restored at the compute device. | 07-25-2013 |
Ben Thomas, Bedford, MA US
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20100217783 | COMMUNICATING WITH DATA STORAGE SYSTEMS - In some aspects, a method includes connecting over a network to a data storage system, the data storage system storing data objects. A dataflow graph that includes nodes representing data processing components connected by links that represent flows of data access an interface of the data storage system. The interface provides functions for accessing the data objects. At least one of the data processing components performs operations on a received input flow of data that enable the functions provided by the interface to modify one or more stored data objects, and performs operations in response to functions provided by the interface to generate an output flow of data. | 08-26-2010 |
Brendan Thomas, Abington, MA US
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20100317465 | PITCHERS AID for STRIKE ZONE ACCURACY - Disclosed is a pitcher's aid for strike zone accuracy that serves the purpose of guiding a pitcher's body to the left or right side, inside/outside, of home plate in order to provide familiarity with how their body can be used to locate a pitch to the desired target. The new and unique invention utilizes a lightweight, rugged material and a small size to stay portable and provide the pitcher with an invention that can be used anywhere and anytime he wishes to practice. Practicing with this invention gives a pitcher confidence when pitching to either side of home, which in turn provides them with more confidence in their pitches, and provides them with the knowledge that they can get the outs needed when called upon by their coach. | 12-16-2010 |
Brittany Anne Thomas, Cambrdige, MA US
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20150080234 | Cell Patterning - The present disclosure provides technologies for achieving cell patterning, as well as patterned cell arrays achieved with such technologies. Provided apparatus and methods are useful in a variety of contexts and provide particular advantages with respect to assessing living cell arrays and/or their responsiveness to stimuli, including identifying and/or characterizing complex cellular responses. | 03-19-2015 |
Corey E. Thomas, Boston, MA US
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20110191854 | METHODS AND SYSTEMS FOR TESTING AND ANALYZING VULNERABILITIES OF COMPUTING SYSTEMS BASED ON EXPLOITS OF THE VULNERABILITIES - A security tool can identify vulnerabilities in a computing system and determine a risk level of the vulnerabilities. The security tool can determine the risk level based on exploits associated with the vulnerabilities. The security tool can determine the risk level based on factors associated with the exploits such as whether an exploit exists, a rank of the exploit, a number of exploits that exist for the vulnerability, a difficulty to identify whether the exploit exists, and an effect of the exploit on the vulnerability. The security tool can a report identifying the vulnerabilities of the computing system, the exploits associated with the vulnerabilities, and the risk level of the vulnerabilities. The report can also include links to information about the exploits. | 08-04-2011 |
Craig A. Thomas, Sudbury, MA US
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20150249602 | SYSTEM ON CHIP LINK LAYER PROTOCOL - A network processing system provides coherent communications between multiple system-on-chips (SOCs). Data messages between SOCs are assigned to virtual channels. An interconnect linking the SOCs divides the communications into discrete data blocks, each of which contains data segments from several virtual channels. The virtual channels can be implemented to control congestion and interference among classes of communications. During transmission, the interconnect distributes the data blocks across several physical ports linking the SOCs. As a result, communications between SOCs is optimized with minimal latency. | 09-03-2015 |
David R. Thomas, Somerville, MA US
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20100261530 | GAME CONTROLLER SIMULATING PARTS OF THE HUMAN ANATOMY - Methods, systems and computer program products of the present invention provide a simulated part of a human anatomy. The simulated human part may be an apparatus associated with a computer program for simulating a part of the human anatomy comprising one or more sensors. The apparatus may be connected to a computing device either through a wired medium or wirelessly. The computing device may receive a data input from at least one of the plurality of sensors that may be located in the vicinity of the apparatus. The sensors may be a pressure sensor, humidity sensor, motion sensor or some other types of sensor. Data received from the apparatus at the computing device may be stored in a database and may be associated with a region of the apparatus having one or more sensors. | 10-14-2010 |
Derek Jon Thomas, Salem, MA US
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20140297413 | System and Method for Promotion of Retail Items and Customer Transactions - Disclosed is a retail imaging system comprising: a mobile communication device having an imaging lens, a retailer software application, and a wireless communication module; a support stand configured to secure and support the mobile communication device at a predetermined distance from a retail item; and a retail imaging server in wireless communication with the wireless communication module for receiving a digital retail image file from the mobile communication device. | 10-02-2014 |
Edwin L. Thomas, Natick, MA US
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20090086208 | BROAD WAVELENGTH RANGE TUNABLE PHOTONIC MATERIALS - The present invention provides polymeric materials arranged as photonic crystals, or portions of photonic crystals, having properties which can be easily tuned over a large range of wavelengths upon exposure to an external stimulus. In some embodiments, the photonic crystals comprise at least one portion which can undergo a change in a physical, chemical, dielectric, or other property upon exposure to an altering stimulus, resulting in a change in a diffracted wavelength of electromagnetic radiation (e.g, light) by the photonic crystal. Embodiments of the invention may advantageously exhibit large stop band tunability and rapid response times. Photonic crystals of the invention may be useful in a wide variety of applications, such as colorimetric sensors, active components of simple display devices, electrically controlled tunable optically pumped laser, photonic switches, multiband filters, and the like. | 04-02-2009 |
20090092803 | SELF-ASSEMBLY TECHNIQUE APPLICABLE TO LARGE AREAS AND NANOFABRICATION - The present invention provides articles and methods for affecting the self-assembly of materials. In some cases, the invention provides an approach for facilitating the self-assembly of various materials, including polymeric materials (e.g., block polymers), nanoparticles, other materials capable of self-assembly, and the like, over relatively large surface areas. Some embodiments of the invention provide articles (e.g., substrates) which, when contacted with a material capable of self-assembly, may produce greater control of self-assembly through the bulk of the material. | 04-09-2009 |
20100099048 | Stop Flow Interference Lithography System - Stop flow interference lithography system for high throughput synthesis of 3-dimensionally patterned polymer particles. The system includes a microfluidic channel containing a stationary oligomer film and a phase mask located adjacent to the microfluidic channel. A source of collimated light is provided for passing the collimated light through the phase mask and into the microfluidic channel for interaction with the oligomer. The passage of the collimated light through the phase mask generates a 3-dimensional distribution of light intensity to induce crosslinking of the oligomer in high intensity regions thereby forming 3-dimensional structures. | 04-22-2010 |
20110190457 | PROTECTIVE POLYMERIC MATERIALS AND RELATED DEVICES - The present invention relates to polymeric materials having enhanced properties. In some cases, the materials may comprise polymers having shape-persistent portions which may enhance the mechanical properties of the material. The materials may exhibit higher stiffness or strength and ductility values, resulting in higher energy absorption and enhanced protection, as well as longer lifetimes for product usage. In some cases, the materials may be optically transparent and lightweight, making them suitable for in various applications including protective materials. | 08-04-2011 |
20120070627 | METHOD FOR NANOPATTERNING BASED ON SELF ASSEMBLY OF A TRIBLOCK TERPOLYMER - Nanolithography and nanoscale device features based on a self-assembled film comprising an ABC triblock terpolymer disposed on a substrate surface are provided. The self-assembled film has a controlled pattern of features over the entire film. Each feature comprises block A, block B, or block C of the ABC triblock terpolymer. One or more blocks (A, B, or C) of the self-assembled film can be transformed by, for example, being removed, to provide a particular pattern geometry for nanolithography. | 03-22-2012 |
Edwin Lorimer Thomas, Natick, MA US
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20120164587 | HYBRID LITHOGRAPHIC METHOD FOR FABRICATING COMPLEX MULTIDIMENSIONAL STRUCTURES - Lithographic Method. The method fabricates complex structures and includes depositing a photoresist onto a substrate, the photoresist including a predominantly thermal band of optical absorption possibly due to the incorporation of a doping agent. A three-dimensional pattern is generated within the resist using a first wavelength of light to effect activation of a photoinitiator to produce a latently photostructured resist. Focused laser spike annealing of the photostructured resist with a second wavelength of light selected to be absorbed by the thermally absorbing band to accelerate the photoinduced reaction in the resist is provided. Three-dimensional direct writing may be performed within the resist to define features not part of the interference pattern and the resist is developed to produce the complex structure. | 06-28-2012 |
Frank Thomas, Lunenburg, MA US
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20090021293 | Low-Power Integrated-Circuit Signal Processor With Wide Dynamic Range - An integrated circuit includes at least three separate power supply terminals, at least one for those portions of the circuit that must accommodate the widest signal-related voltage excursion, at least one for those that experience substantially smaller signal-related voltage excursions, and a common terminal. | 01-22-2009 |
Geoff Thomas, Needham, MA US
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20120036070 | MODULAR TRANSACTIONAL BANKING PLATFORM - A modular transactional banking platform is disclosed that separates the chassis of the account from all of the remaining optional package features, allowing users to select and customize the various components they wish to package into their account. The banking platform is constructed using a modular one-to-many approach that separates the “chassis” from the “features” in a manner that enables customers (and the bank) to create multiple account combinations and the flexibility to change as their needs adjust. The process of account creation may be completed in a self-service manner in an online environment or in person with the assistance of a banker. The features of the account are then attached to the account chassis as money applications or money applications in a customer selected bundle or al a carte fashion. | 02-09-2012 |
20120179604 | METHOD AND SYSTEM FOR ALLOWING A USER TO CONTROL THE ORDER IN WHICH TRANSACTIONS ARE POSTED - A method and system is provided that allows a banking customer to access their bank account via an online banking interface and manage the order in which transactions are posted against their account in a manner that allows them to minimize or eliminate the occurrence of an overdraft condition. Should the monetary balance within the account fall below zero, creating a potential overdraft condition, the customer is notified that such a zero or negative balance condition exists. The customer, using the user interface, can then access the account to arrange the various posted items in any order they want. Further, the customer is provided with the option of returning items to avoid the overdraft condition entirely. | 07-12-2012 |
20120179605 | SYSTEM FOR ALLOWING A USER TO CONTROL THE MANNER AND AMOUNT PAID TO SETTLE ACCOUNT TRANSACTIONS - A method and system is provided that allows a banking customer to manage repayment of larger bills by breaking them into a series of smaller more manageable payments that are repaid over a number of payments that are spread over a longer period of time. As bills are presented to the bank account customer, the customer, using the user interface can select one of the bills due for payment and request that they be allowed to break the bill into smaller payments. Once approved the larger bill is broken into a predetermined number of smaller repayments that are then more easily managed by the customer in a manner that eases their cash flow. | 07-12-2012 |
Geoffrey Thomas, Needham, MA US
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20130091056 | SYSTEM AND METHOD FOR MAINTAINING AND CUSTOMIZING USER ACCOUNTS - A system provides for a customer to maintain and customize a user account with a banking institution. A server maintains pre-established packages providing a group of services and applications providing a specific service. The server also maintains user accounts, each associated with a particular customer and with one or more services. The server processes requests to designate and customize packages and applications associated with a customer account. Graphical user interfaces (GUIs) are provided that allow for the customer to build, customize, and view the customer account. A selection GUI includes service icons associated with respective services and selectable by a customer to associate the respective services with the customer account. A customization GUI includes service windows that correspond to respective service icons, that include an overview summary of the respective services, and that are selectable to view and edit features of the respective services. | 04-11-2013 |
Grace M. Thomas, Boston, MA US
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20140199329 | METHODS FOR TREATING AND PREVENTING NEUTROPHIL-DERIVED NET TOXICITY AND THROMBOSIS - Embodiments of the technology described herein are based upon the discoveries that neturophil extracellular traps (NETs) provide a stimulus for thrombus formation and that NETs are present in stored blood products. Accordingly, some embodiments relate to methods of treating and preventing toxicity of NETs and thrombosis caused by NETs. Additional embodiments are directed towards methods of treating stored blood products to prevent transfusion-related injuries. | 07-17-2014 |
Horatio R. Thomas, Cambridge, MA US
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20150233895 | DIAGNOSIS AND TREATMENT OF INVASIVE ASPERGILLOSIS - Methods for diagnosing, treating, and monitoring the treatment of invasive aspergillosis (IA) are described. The methods can include detecting the presence of one or more volatile organic compounds (VOCs) in the breath of subjects suspected of having IA. | 08-20-2015 |
Jeffrey Thomas, Winchester, MA US
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20150027217 | CONFINING PRESSURE MEASUREMENT FOR ZONAL ISOLATION EVALUATION - Apparatus and methods for measuring confining pressure, axial strain and radial strain of zonal isolation materials are described. This information is useful for evaluating these materials and predicting seal performance and potential failures of these materials. | 01-29-2015 |
Jermaine Thomas, Chelsea, MA US
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20100160258 | Bicyclic aryl sphingosine 1-phosphate analogs - Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors. | 06-24-2010 |
20100160357 | Heterobicyclic sphingosine 1-phosphate analogs - Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors. | 06-24-2010 |
20120190649 | BICYCLIC ARYL SPHINGOSINE 1-PHOSPHATE ANALOGS - Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors. | 07-26-2012 |
20120208819 | HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS - The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases. | 08-16-2012 |
20130059821 | BICYCLIC ARYL SPHINGOSINE 1-PHOSPHATE ANALOGS - Compounds that have agonist activity at one or more of the SIP receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at SIP receptors. | 03-07-2013 |
20140100195 | Heterobicyclic sphingosine 1-phosphate analogs - Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors. | 04-10-2014 |
20140309190 | BICYCLIC ARYL SPHINGOSINE 1-PHOSPHATE ANALOGS - Compounds that have agonist activity at one or more of the S | 10-16-2014 |
20140371209 | S1P Modulating Agents - Compounds of formula (I) or (II) can modulate the activity of SIP receptors. | 12-18-2014 |
20150232492 | HETEROBICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS - Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors. | 08-20-2015 |
Joe Thomas, Reading, MA US
Patent application number | Description | Published |
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20160071678 | MECHANICAL DISCONNECT SWITCH WITH INTEGRATED FUSE PROTECTION - A circuit protection assembly (CPA) is disposed between a source of power and a circuit to be protected. The CPA comprises a mounting block having a bore extending therethrough and a recess cavity on a first surface of the mounting block. A post having a first end is disposed within the recess cavity and a body portion extends through the bore. The body portion configured to receive a terminal and the second end configured to receive a securing mechanism. A fuse having a centrally disposed aperture is configured to receive the body portion of the post and to receive the terminal for connection to a circuit to be protected. An insulator disposed on the terminal and disposed beneath the securing mechanism. The insulator configured to isolate the post from the terminal and the fuse while allowing the securing mechanism to apply an amount of torque. | 03-10-2016 |
Jonathan Moulton Thomas, Nantucket, MA US
Patent application number | Description | Published |
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20080208213 | Devices and methods for the controlled formation and closure of vascular openings - The present invention includes systems, devices and methods for percutaneously forming an aperture within a tissue structure or vessel and closing the aperture in a manner which optimizes hemostasis and healing. The invention in one aspect includes implantable devices which are used to seal the tissue aperture upon closure of the aperture after a percutaneous or endovascular procedure. | 08-28-2008 |
Joshua D. Thomas, Natick, MA US
Patent application number | Description | Published |
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20120321583 | Protein-Polymer-Drug Conjugates - A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L | 12-20-2012 |
20130101546 | Protein-Polymer-Drug Conjugates - A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L | 04-25-2013 |
20130309192 | Auristatin Compounds and Conjugates Thereof - Auristatin compounds and conjugates thereof are provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L | 11-21-2013 |
20140017265 | Terminally Modified Polymers and Conjugates Thereof - A terminally modified polymer is provided herein. At least one terminus of the polymer is —O—(CH | 01-16-2014 |
20140134127 | Protein-Polymer-Drug Conjugates - A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L | 05-15-2014 |
20150044160 | PROTEIN-POLYMER-DRUG CONJUGATES - A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L | 02-12-2015 |
20150064130 | PROTEIN-POLYMER-DRUG CONJUGATES - Auristatin compounds and conjugates thereof are provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L | 03-05-2015 |
20150104407 | PROTEIN-POLYMER-DRUG CONJUGATES - A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions are also described. | 04-16-2015 |
20150125474 | PROTEIN-POLYMER-DRUG CONJUGATES - A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions are also described. | 05-07-2015 |
20160067353 | PROTEIN-POLYMER-DRUG CONJUGATES - A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L | 03-10-2016 |
Kyle A. Thomas, Cambridge, MA US
Patent application number | Description | Published |
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20130122474 | METHOD AND SYSTEM FOR VERIFYING AND DETERMINING ACCEPTABILITY OF UNVERIFIED SURVEY ITEMS - A computer implemented method for determining acceptability of an unverified survey item can include outputting interactive displays comprising a survey. The survey can include a verified quantitative item for measuring respondent positions along a continuum for a first trait, and the verified quantitative item can include a prompt and a plurality of quantitative response choices. The survey can include an unverified non-quantitative item for measuring respondent positions along the continuum for the first trait, and the unverified non-quantitative item can include a prompt and a plurality of non-quantitative response choices. A plurality of responses to the verified quantitative item and the plurality of unverified non-quantitative items can be received from a plurality of users. Psychometric acceptability of the unverified non-quantitative item can be assessed based at least in part on the plurality of responses to the unverified non-quantitative item relative to the plurality of responses to the verified quantitative item. | 05-16-2013 |
20140257990 | METHOD AND SYSTEM FOR DETERMINING CORRELATIONS BETWEEN PERSONALITY TRAITS OF A GROUP OF CONSUMERS AND A BRAND/PRODUCT - A computer implemented system and method determines correlations between one or more personality traits of a group of consumers and one or more brand/product. A first collection of consumer motivations of the group of consumers are determined based on associations between possible consumer motivations and the one or more personality traits. A second collection of consumer motivations are derived from the first collection of consumer motivations, where each consumer motivation of the second collection has a correlation with the one or more brand/product. Correlations between the personality traits and the brand/product are determined and output by identifying which of the one or more personality traits contributed to each of the consumer motivations of the second collection based on the associations between the possible consumer motivations and the one or more personality traits from the group of consumers. | 09-11-2014 |
Lawrence Thomas, Easton, MA US
Patent application number | Description | Published |
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20100130413 | TREATMENT FOR AGE-RELATED MACULAR DEGENERATION AND OTHER DISEASES OF THE EYE - A method is disclosed for treating diseases or disorders of the eye involving undesired neovascularization by administration of a complement inhibitory protein such as soluble complement receptor type I (sCR1). The present invention relates to the direct treatment of macular degeneration, particularly age-related macular degeneration (AMD), by administering a complement inhibitory protein intraocularly or systemically. | 05-27-2010 |
Lawrence J. Thomas, Easton, MA US
Patent application number | Description | Published |
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20110274685 | ANTIBODIES THAT BIND HUMAN CD27 AND USES THEREOF - Isolated monoclonal antibodies which bind to human CD27 and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies. | 11-10-2011 |
20120213771 | ANTIBODIES THAT BIND HUMAN CD27 AND USES THEREOF - Isolated monoclonal antibodies which bind to human CD27 and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies. | 08-23-2012 |
20150337047 | ANTIBODIES THAT BIND HUMAN CD27 AND USES THEREOF - Isolated monoclonal antibodies which bind to human CD27 and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies. | 11-26-2015 |
Lawrence J. Thomas, South Easton, MA US
Patent application number | Description | Published |
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20090142362 | Peptide-based vaccine compositions to endogenous cholesteryl ester transfer protein (CETP) - Improved vaccine compositions and methods of use thereof are described that elicit production of antibodies in an individual to the individual's own endogenous cholesteryl ester transfer protein (CETP). | 06-04-2009 |
20100129396 | V. CHOLERAE HYPEREXPRESSING RECOMBINANT CHOLERA TOXIN B SUBUNIT SHOWING DUAL IMMUNOGENICITY - Oral immunogenic compositions imparting dual protection against enterotoxigenic labile toxin (LT)-expressing | 05-27-2010 |
20130122039 | V. Cholera hypereexpressing recombinant cholera toxin B subunit showing dual immunogenicity - Immunogenic compositions imparting dual protection against enterotoxigenic labile toxin (LT)-expressing | 05-16-2013 |
Lynne Thomas, Ayer, MA US
Patent application number | Description | Published |
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20130075484 | SYSTEMS AND METHODS UTILIZING A WIRELESS MESH NETWORK - In some examples, a wireless controller is utilized within a wireless mesh network. The wireless controller includes a control module configured to manage at least one energy device via a pneumatic pressure line based on one or more parts of an energy profile; and a network interface module configured to transmit energy data to a management server and receive the one or more parts of the energy profile from the management server. | 03-28-2013 |
Marcel A.c. Thomas, Cambridge, MA US
Patent application number | Description | Published |
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20140259604 | System and Method for Sterile Sheathing of a Medical Probe - An apparatus and a method for sheathing a medical device, tool, instrument or probe (generally, probe) is provided. Among other aspects, a probe support jig capable of supporting the probe is provided, which includes a mechanical coupling for accepting a sheath on a sheath shell. In use, the sheath shell is coupled at one end thereof to the support jig and the probe is fed into the sheath, which is coupled to the sheath shell at another end thereof. | 09-18-2014 |
Marion Thomas, Lancaster, MA US
Patent application number | Description | Published |
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20100325016 | METHOD AND SYSTEM FOR DYNAMICALLY GENERATING A GALLERY OF AVAILABLE DESIGNS FOR KIT CONFIGURATION - Methods, computer-readable storage media, and apparatuses for dynamically generating a gallery of available designs for a particular kit configuration including a plurality of different products are presented. | 12-23-2010 |
Matthew Thomas, Cambridge, MA US
Patent application number | Description | Published |
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20150196589 | FORMULATIONS FOR ALTERATION OF BIOPHYSICAL PROPERTIES OF MUCOSAL LINING - Conductive formulations containing conductive agents, such as salts, ionic surfactants, or other substances that are in an ionized state or easily ionized in an aqueous or organic solvent environment, and methods of use, have been developed. One or more active agents, such as antivirals, antimicrobials, anti-inflammatories, proteins or peptides, may optionally be included with the formulation. The active agent may be administered with or incorporated into the formulation, or may be administered after the conductive formulation is administered. When applied to mucosal lining fluids, the formulation alters the physical properties such as the surface tension, surface elasticity, and bulk viscosity of the mucosal lining. The formulation is administered in an amount sufficient to alter biophysical properties in the mucosal linings of the body. The formulations may be administered for several different purposes: reducing the spreading of infectious diseases, both viral and bacterial, such as SARS, influenza, tuberculosis, and RSV in humans and hoof and mouth disease in cloven-footed animals; minimizing ambient contamination due to particle formation during breathing, coughing, sneezing, or talking which is particularly important in the clean room applications; decreasing or preventing the occurrence of obstructive sleep apnea and some cases of irritable bowel syndrome; and controlling the uptake kinetics of drug molecules and pathogens. | 07-16-2015 |
Melissa K. Thomas, Boston, MA US
Patent application number | Description | Published |
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20090138978 | Use of bridge-1 and activators and inhibitors thereof in the treatment of insulin deficiency and diabetes - The present invention is directed to the use of Bridge-1 polynucleotides and Bridge-1 polypeptides, as well as activators and inhibitors of Bridge-1 activity, in the treatment of Bridge-1 mediated disorders, including diabetes. | 05-28-2009 |
Nicole Thomas, Bolton, MA US
Patent application number | Description | Published |
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20150114429 | AQUEOUS CLEAN SOLUTION WITH LOW COPPER ETCH RATE FOR ORGANIC RESIDUE REMOVAL IMPROVEMENT - A cleaning composition and process for cleaning post-chemical mechanical polishing (CMP) residue and contaminants from a microelectronic device having said residue and contaminants thereon. The cleaning compositions include at least one quaternary base, at least one amine, at least one corrosion inhibitor, and at least one solvent. The composition achieves highly efficacious cleaning of the post-CMP residue and contaminant material from the surface of the microelectronic device while being compatible with barrier layers. | 04-30-2015 |
Nicole E. Thomas, Bolton, MA US
Patent application number | Description | Published |
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20140326633 | COMPOSITIONS AND METHODS FOR THE SELECTIVE REMOVAL OF SILICON NITRIDE - Compositions useful for the selective removal of silicon nitride materials relative to poly-silicon, silicon oxide materials and/or silicide materials from a microelectronic device having same thereon. The removal compositions include fluorosilicic acid, silicic acid, and at least one organic solvent. Typical process temperatures are less than about 100° C. and typical selectivity for nitride versus oxide etch is about 200:1 to about 2000:1. Under typical process conditions, nickel-based silicides as well as titanium and tantalum nitrides are largely unaffected, and polysilicon etch rates are less than about 1 Å min | 11-06-2014 |
Nicole E. Thomas, Marlborough, MA US
Patent application number | Description | Published |
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20140038420 | COMPOSITION AND PROCESS FOR SELECTIVELY ETCHING METAL NITRIDES - A removal composition and process for selectively removing a first metal gate material (e.g., titanium nitride) relative to a second metal gate material (e.g., tantalum nitride) from a microelectronic device having said material thereon. The removal composition can include fluoride or alternatively be substantially devoid of fluoride. The substrate preferably comprises a high-k/metal gate integration scheme. | 02-06-2014 |
Paul Thomas, Medfield, MA US
Patent application number | Description | Published |
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20100258411 | Intelligent Conveyor Adjustment System - The invention is an Intelligent Conveyor Adjustment System (ICAS). The ICAS gives the user a way to adjust guide rails and other devices used in a conveyor system with actuators that can receive instructions based on a specific communications interface, such an interface may consist of but is not limited to serial wired network, an 802.11 compatible network, a power line network, and as described in the examples a wireless network, in a fashion to position rails or other devices on a conveyor system or in machines associated with a conveyor system. The actuators can be but are not limited to varying types, linear, rotary, push/pull covered cable, flexible strips, lever, pivoting, scissor, or other dual actuating mechanisms. The ACMs are used to control the actuators which control the relative position and shape of guide rails on the sides of the conveyor as well as position of various other conveyor entities such as, but not limited to, timing screws, labelers, marking machines, barcode readers, and fillers. | 10-14-2010 |
Paul Linden Thomas, Lunenburg, MA US
Patent application number | Description | Published |
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20150229266 | CPV SYSTEM AND METHOD THEREFOR - A concentrated photovoltaic system ( | 08-13-2015 |
Ranny M. Thomas, Sharon, MA US
Patent application number | Description | Published |
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20140364423 | Pyrazinopyrazines and Derivatives as Kinase Inhibitors - This invention relates to compounds of the general formula: | 12-11-2014 |
20150225436 | PHOSPHOROUS DERIVATIVES AS KINASE INHIBITORS - The invention features compounds of the general formula: | 08-13-2015 |
Ranny Mathew Thomas, Waltham, MA US
Patent application number | Description | Published |
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20090281155 | Dimeric Small Molecule Potentiators of Apoptosis - Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of The compoundic mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology. | 11-12-2009 |
20090312379 | Dimeric Small Molecule Potentiators of Apoptosis - Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of The compoundic mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology. | 12-17-2009 |
20110124585 | Dimeric Small Molecule Potentiators of Apoptosis - Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of The compoundic mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology. | 05-26-2011 |
Richard Thomas, Belmont, MA US
Patent application number | Description | Published |
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20090149871 | Devices and methods for treating morbid obesity - The present invention provides devices and methods for attachment of an implanted device, such as an artificial stoma device, a gastrointestinal sleeve device or an attachment cuff, within a patient's digestive tract for treatment of obesity. Special surgical fasteners provide a lasting and durable attachment to the gastrointestinal tissue without causing excessive pressure that could result in tissue erosion and detachment of the implanted device. Fastener delivery devices that facilitate peroral placement and deployment of fasteners and secondary devices are also provided. Also described are implantable devices and attachment means that avoid causing excessive pressure within the tissue by having compliance that is compatible with the gastrointestinal tissues where it is attached. | 06-11-2009 |
Richard Thomas, Lincoln, MA US
Patent application number | Description | Published |
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20090186094 | Injectable and Swellable Microspheres for Tissue Bulking - The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres useful for tissue bulking. The invention also relates to methods of tissue bulking, particularly for the treatment of Gastro-esophageal reflux disease, urinary incontinence, or urinary reflux disease, using the injectable compositions. | 07-23-2009 |
20110033508 | INJECTABLE MICROSPHERES FOR DERMAL AUGMENTATION AND TISSUE BULKING - The present invention relates to elastic, hydrophilic and substantially spherical microspheres useful for dermal augmentation and tissue bulking. The invention provides injectable compositions comprising the microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further provides methods of dermal augmentation and tissue bulking, particularly for the treatment of skin contour deficiencies, Gastro-esophageal reflux disease, urinary incontinence, and urinary reflux disease, using the injectable compositions. | 02-10-2011 |
20130323316 | INJECTABLE MICROSPHERES FOR DERMAL AUGMENTATION AND TISSUE BULKING - The present invention relates to elastic, hydrophilic and substantially spherical microspheres useful for dermal augmentation and tissue bulking. The invention provides injectable compositions comprising the microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further provides methods of dermal augmentation and tissue bulking, particularly for the treatment of skin contour deficiencies, Gastro-esophageal reflux disease, urinary incontinence, and urinary reflux disease, using the injectable compositions. | 12-05-2013 |
20130323317 | INJECTABLE AND SWELLABLE MICROSPHERES FOR TISSUE BULKING - The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres useful for tissue bulking. The invention also relates to methods of tissue bulking, particularly for the treatment of Gastro-esophageal reflux disease, urinary incontinence, or urinary reflux disease, using the injectable compositions. | 12-05-2013 |
20140065233 | INJECTABLE MICROSPHERES FOR DERMAL AUGMENTATION AND TISSUE BULKING - The present invention relates to elastic, hydrophilic and substantially spherical microspheres useful for dermal augmentation and tissue bulking. The invention provides injectable compositions comprising the microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further provides methods of dermal augmentation and tissue bulking, particularly for the treatment of skin contour deficiencies, Gastro-esophageal reflux disease, urinary incontinence, and urinary reflux disease, using the injectable compositions. | 03-06-2014 |
R. Mathew Thomas, Sharon, MA US
Patent application number | Description | Published |
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20090156596 | Unsaturated Heterocyclic Derivatives - This invention relates to compounds of the general formula: | 06-18-2009 |
20090176781 | Acetylenic Heteroaryl Compounds - This invention relates to compounds of the general formula: | 07-09-2009 |
20110288078 | PYRAZINOPYRAZINES AND DERIVATIVES AS KINASE INHIBITORS - This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use. | 11-24-2011 |
20120135986 | Bicyclic Heteroaryl Compounds - This invention relates to compounds of the general formula: | 05-31-2012 |
20120178716 | Unsaturated Heterocyclic Derivatives - This invention relates to compounds of the general formula: | 07-12-2012 |
20120202776 | PHOSPHORUS DERIVATIVES AS KINASE INHIBITORS - The invention features compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use. | 08-09-2012 |
20130005738 | Monocyclic Heteroaryl Compounds - This invention relates to compounds of the general formula: | 01-03-2013 |
20130018046 | Acetylenic Heteroaryl Compounds - This invention relates to compounds of the general formula: | 01-17-2013 |
20130196979 | Bicyclic Heteroaryl Compounds - This invention relates to compounds of the general formula: | 08-01-2013 |
20130225527 | Phosphorus Derivatives as Kinase Inhibitors - The invention features compounds of the general formula: | 08-29-2013 |
20130225528 | Phosphorus Derivatives as Kinase Inhibitors - The invention features compounds of the general formula: | 08-29-2013 |
20130231337 | Bicyclic Heteroaryl Compounds - This invention relates to compounds of the general formula: | 09-05-2013 |
20140066406 | Phosphorus Derivatives as Kinase Inhibitors - The invention features compounds of the general formula: | 03-06-2014 |
20140288082 | Bicyclic Heteroaryl Compounds - This invention relates to compounds of the general formula: | 09-25-2014 |
R. Matthew Thomas, Sharon, MA US
Patent application number | Description | Published |
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20090149471 | Monocyclic Heterocyclic Compounds - This invention relates to compounds of the general formula: | 06-11-2009 |
Robert Thomas, Lexington, MA US
Patent application number | Description | Published |
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20080267175 | ACCELERATION OF LABEL DISTRIBUTION PROTOCOL (LDP) SESSION SETUP - In one embodiment, a network device executes a Label Distribution Protocol (LDP) that sends LDP Hello messages at a default rate. The rate of sending LDP Hello messages is modified to accelerate the establishment of an LDP session between the network device and an LDP peer. | 10-30-2008 |
Robert F. Thomas, Lakeville, MA US
Patent application number | Description | Published |
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20090290364 | Housing for suspendable assembly - The invention provides an improvement in suspendable structures and assemblies such as linear lighting fixtures/luminaires that are intended to be suspended from ceilings or other such structures. The housings of the assemblies are designed to include at least one structural member with prestressing in at least along a major longitudinal axis over at least a portion of the length of the member. Once the structural member is incorporated into the housing and overall assembly, the housing and/or assembly is substantially planar and uniform once the assembly is suspended, making the assembly both stronger and more aesthetically appealing. Other embodiments showing extensions to the invention are also disclosed. | 11-26-2009 |
Robert H. Thomas, Lexington, MA US
Patent application number | Description | Published |
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20090144443 | DIFFERENTIATED ROUTING USING TUNNELS IN A COMPUTER NETWORK - In one embodiment, one or more tunnel mesh groups may be established in at least a portion of a computer network, where each tunnel mesh group corresponds to a differentiated routing profile. Traffic may then be received at the portion of the computer network, the traffic indicating a particular differentiated routing profile (e.g., based on a received label corresponding to the differentiated routing profile as advertised by the portion of the computer network). Accordingly, the traffic may be routed through the portion of the computer network along a tunnel of a particular tunnel mesh group corresponding to the particular differentiated routing profile traffic. | 06-04-2009 |
Robert J. Thomas, Newton, MA US
Patent application number | Description | Published |
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20100069762 | System And Method For Assessing Sleep Quality - An assessment of sleep quality and sleep disordered breathing is determined from cardiopulmonary coupling between two physiological data series. An R-R interval series is derived from an electrocardiogram (ECG) signal. The normal beats from the R-R interval series are extracted to produce a normal-to-normal interval series. The amplitude variations in the QRS complex are used to extract a surrogate respiration signal (i.e., ECG-derived respiration) associated with the NN interval series. The two series are corrected to remove outliers, and resampled. The cross-spectral power and coherence of the two resampled signals are calculated over a plurality of coherence windows. For each coherence window, the product of the coherence and cross-spectral power is used to calculate coherent cross-power. Using the appropriate thresholds for the coherent cross-power, the proportion of sleep spent in CAP, non-CAP, and wake and/or REM are determined. Coherent cross-power can be applied to differentiate obstructive from non-obstructive disease, and admixtures of the same. | 03-18-2010 |
Robert Joseph Thomas, Newton, MA US
Patent application number | Description | Published |
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20150343161 | Detection of Periodic Breathing During CPAP Therapy - An improvement to a breathing therapy machine to detect and rate occurrences of periodic breathing and to alter the therapy delivered to a user of the device based on the rating. | 12-03-2015 |
Samuel W. Thomas, Boston, MA US
Patent application number | Description | Published |
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20090215189 | Sensor of species including toxins and chemical warfare agents - The present invention generally relates to emissive materials, devices, and related methods. In some cases, the present invention provides sensors and methods for the determination of analytes, wherein the analytes may be determined by monitoring, for example, a change in an optical signal of an emissive material upon exposure to an analyte. The analyte and the emissive material may interact via a chemical reaction, such as an oxidative addition reaction, or other chemical, biochemical or biological interaction (e.g., recognition), to form a new emissive species. In some cases, the present invention may be useful in the detection of a wide variety of analytes, such as toxins, chemical warfare agents, and explosives. The present invention also provides emissive compounds, and related methods, including metal complexes that are capable of interacting with an analyte to produce a change in the emission of the compound. Some advantages of the present invention include the determination of analytes with high specificity and sensitivity and the ability to fabricate simplified and highly portable devices. | 08-27-2009 |
20090240040 | PURIFICATION OF A BIVALENTLY ACTIVE ANTIBODY USING A NON-CHROMATOGRAPHIC METHOD - The present invention discloses a method of purifying bivalent antibodies or antibody fragments that are active at both Fab sites from a source of antibodies or antibody fragments using a non-chromatographic method that includes inducing the formation of cyclic immunoglobulin aggregates by addition of multivalent hapten to a salt solution of soluble antibodies or antibody fragments, wherein the multivalent hapten possesses a linker between the two haptens effective to prevent the binding of both haptens of the ligand to the same antibody or antibody fragment. | 09-24-2009 |
20090298191 | Lateral Flow and Flow-through Bioassay Devices Based On Patterned Porous Media, Methods of Making Same, and Methods of Using Same - Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region. | 12-03-2009 |
20100022011 | DETERMINATION OF EXPLOSIVES INCLUDING RDX - The present invention provides sensors and methods for determination of an analyte. The analytes may be determined by monitoring, for example, a change in an optical signal of an emissive material upon exposure to an analyte. In some embodiments, the analyte and the emissive material may interact via a chemical reaction, or other chemical, biochemical or biological interaction (e.g., recognition), to form a new emissive species. In some cases, the present invention may be used for the detection of analytes such as explosives (e.g., RDX, PETN). Methods of the present invention may be advantageous in that the high sensitivity of luminescence (e.g., fluorescence) spectroscopy can allow for the reliable detection of small changes in luminescence intensity. | 01-28-2010 |
20130128036 | Lateral Flow and Flow-through Bioassay Devices Based on Patterned Porous Media, Methods of Making Same, and Methods of Using Same - Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region. | 05-23-2013 |
20140234881 | LATERAL FLOW AND FLOW-THROUGH BIOASSAY DEVICES BASED ON PATTERNED POROUS MEDIA, METHODS OF MAKING SAME, AND METHODS OF USING SAME - Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region. | 08-21-2014 |
Samuel W. Thomas, Quincy, MA US
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20100303672 | DETERMINATION OF EXPLOSIVES INCLUDNIG RDX - The present invention provides sensors and methods for determination of an analyte. The analytes may be determined by monitoring, for example, a change in an optical signal of an emissive material upon exposure to an analyte. In some embodiments, the analyte and the emissive material may interact via a chemical reaction, or other chemical, biochemical or biological interaction (e.g., recognition), to form a new emissive species. In some cases, the present invention may be used for the detection of analytes such as explosives (e.g., RDX, PETN). Methods of the present invention may be advantageous in that the high sensitivity of luminescence (e.g., fluorescence) spectroscopy can allow for the reliable detection of small changes in luminescence intensity. | 12-02-2010 |
Scott D. Thomas, Waltham, MA US
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20150260210 | Clamp For Internally Coupling and Decoupling Two Components - A clamp for internally coupling and decoupling two components. The clamp can include a base fittable within an interior of at least one of two components to be coupled together. The clamp can also include an engagement member movably supported about the base. The engagement member can interface with and engage interior portions of the two components when in a coupled position separated from the interior portions of the two components when in a decoupled position. The clamp can further include a wedge movably supported about the base to facilitate movement of the engagement member between the coupled and the decoupled positions. In addition, the clamp can include a secure and release mechanism operable with the base and the wedge to alternately secure the wedge to maintain the engagement member in the coupled position and release the wedge to facilitate movement of the engagement member to the decoupled position. | 09-17-2015 |
Sherry L. Thomas, Hanover, MA US
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20090078710 | APPARATUS AND METHOD OF THAWING AND WARMING BABY FOOD - An apparatus and method of thawing and warming comestible product. The apparatus includes a container having an inlet and an outlet, a handle coupled to the container, and a valve coupled to the container adjacent to the outlet. The valve is operable to control fluid flow through the container. The device also includes a lid coupled to the container. The lid includes at least one aperture in fluid communication with the inlet and allows fluid flow therethrough. | 03-26-2009 |
20100130462 | LANOLIN COMPOSITIONS AND METHODS FOR MAKING AND USING SAME - A composition suitable for application to the skin comprising lanolin, an oil, an anti-oxidant, and a combination thereof. The composition is suitable for particular application to a human breast. | 05-27-2010 |
Simon Thomas, Norwood, MA US
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20100258411 | Intelligent Conveyor Adjustment System - The invention is an Intelligent Conveyor Adjustment System (ICAS). The ICAS gives the user a way to adjust guide rails and other devices used in a conveyor system with actuators that can receive instructions based on a specific communications interface, such an interface may consist of but is not limited to serial wired network, an 802.11 compatible network, a power line network, and as described in the examples a wireless network, in a fashion to position rails or other devices on a conveyor system or in machines associated with a conveyor system. The actuators can be but are not limited to varying types, linear, rotary, push/pull covered cable, flexible strips, lever, pivoting, scissor, or other dual actuating mechanisms. The ACMs are used to control the actuators which control the relative position and shape of guide rails on the sides of the conveyor as well as position of various other conveyor entities such as, but not limited to, timing screws, labelers, marking machines, barcode readers, and fillers. | 10-14-2010 |
Stephanie C. Thomas, Upton, MA US
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20110073795 | FIRE EXTINGUISHING COMPOSITION - A fire extinguishing composition is provided that is suitable for use as a fire extinguishing agent in fire suppression, particularly in off-road vehicles exposed to low ambient temperature environments. The fire extinguishing composition includes an aqueous solution of potassium formate. In an embodiment, the fire extinguishing composition includes an aqueous solution of potassium formate and an aqueous film forming foam. In an embodiment, the fire extinguishing composition is an aqueous solution including an aqueous film forming foam, potassium formate and potassium acetate in water. | 03-31-2011 |
Stephanie C. Thomas, Milford, MA US
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20140251643 | DEVICE FOR INTRODUCING AN AGENT INTO A FIRE SUPPRESSION SYSTEM - An exemplary device for introducing an agent into a fire suppression fluid includes a housing having an inlet configured to receive the agent into the housing. The housing also has an outlet configured to release the agent from the housing. A stopper is moveable between a closed position where the stopper prevents passage from the inlet to the outlet and an open position where the inlet is in communication with the outlet. A vane causes movement of the stopper from the closed position to the open position responsive to contact between the vane and fire suppression fluid flowing past the vane. | 09-11-2014 |
Steven Thomas, Cambridge, MA US
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20140360699 | VARIABLE GEOMETRY HEAT SINK ASSEMBLY - A heat sink assembly and method wherein a base plate is mountable to a heat source and spaced fins on the base plate define flow channels therebetween. Self actuating louvers are configured to increase flow through select channels in response to increased temperatures. | 12-11-2014 |
20160046080 | SYSTEMS AND METHODS FOR AN IMPROVED PEEL OPERATION DURING ADDITIVE FABRICATION - According to some aspects, a method of additive fabrication wherein a plurality of layers of material are formed is provided. The method may comprise forming a layer of material in contact with a container, and subsequent to the forming of the layer of material, actively bending the container around at least one fixed point such that the layer of material separates from the container. According to some aspects, an additive fabrication apparatus configured to form a plurality of layers of material is provided. The apparatus may comprise a container, a build platform, one or more force generators, and at least one controller configured to, subsequent to formation of a layer of material in contact with the container, actively bend the container around at least one fixed point via the one or more force generators, such that the layer of material separates from the container. | 02-18-2016 |
Zachary Thomas, Cambridge, MA US
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20120126803 | METHOD AND APPARATUS FOR NON-DESTRUCTIVE EVALUATION OF MATERIALS - Methods and apparatus for characterizing composite materials for manufacturing quality assurance (QA), periodic inspection during the useful life, or for forensic analysis/material testing. System are provided that relate eddy-current sensor responses to the fiber layup of a composite structure, the presence of impact damage on a composite structure with or without a metal liner, volumetric stress within the composite, fiber tow density, and other NDE inspection requirements. Also provided are systems that determine electromagnetic material properties and material dimensions of composite materials from capacitive sensor inspection measurements. These properties are related to the presence of buried defects in non-conductive composite materials, moisture ingress, aging of the material due to service or environmental/thermal exposure, or changes in manufacturing quality. | 05-24-2012 |
20150212044 | Method and Apparatus for Non-Destructive Evaluation of Materials - Methods and apparatus for characterizing composite materials for manufacturing quality assurance (QA), periodic inspection during the useful life, or for forensic analysis/material testing. System are provided that relate eddy-current sensor responses to the fiber layup of a composite structure, the presence of impact damage on a composite structure with or without a metal liner, volumetric stress within the composite, fiber tow density, and other NDE inspection requirements. Also provided are systems that determine electromagnetic material properties and material dimensions of composite materials from capacitive sensor inspection measurements. These properties are related to the presence of buried defects in non-conductive composite materials, moisture ingress, aging of the material due to service or environmental/thermal exposure, or changes in manufacturing quality. | 07-30-2015 |