Patent application number | Description | Published |
20080200377 | POLYMER PARTICLES - A composition including a solution suitable for introduction into a blood vessel comprising particles comprising a treatment agent and a polymeric product of at least one activated diamine and at least one activated dicarboxylic acid. A method including introducing a delivery device into a blood vessel; and introducing a solution into the blood vessel, the solution comprising particles comprising a treatment agent and a polymeric product of at least one activated diamine and at least one activated dicarboxylic acid, wherein the activated diamine comprises a product of a diol and an amino acid. A method including combining a treatment agent and a polymeric product of at least one activated diamine and at least one activated dicarboxylic acid; and forming particles of the combination suitable for delivery through a blood vessel. | 08-21-2008 |
20090005849 | Methods and apparatuses for coating a lesion - A method and apparatus to treat regions of a vessel is described. A protein elastin-based polymer is released from the apparatus to coat the vessel lining as a primary therapy or an adjunct therapy with the delivery and deployment of a stent with or without drug coating. The protein elastin-based polymer may include a triblock structure having an elastin pentapeptide as the flanking block and a hydrophilic variant of the pentapeptide as the middle block. Both the flanking and middle blocks can be modified to change the structural and chemical properties of the polymer. In particular, the protein elastin based polymer is adapted to perform at least one of controlling release of a treatment agent, stimulating endothelial cell growth and stabilizing the vulnerable plaque to prevent rupture of the vulnerable plaque. | 01-01-2009 |
20090041845 | Implantable medical devices having thin absorbable coatings - Disclosed herein is a coating having a layer that includes a matrix phase and a dispersed phase substantially immiscible in the matrix phase and methods of using the same. | 02-12-2009 |
20090258028 | Methods Of Forming Coatings For Implantable Medical Devices For Controlled Release Of A Peptide And A Hydrophobic Drug - This invention is generally related to methods of forming coatings for implantable medical devices, such as drug delivery vascular stents. The methods are for forming coatings to control the release of a peptide such as RGD, and a hydrophobic drug. Both single layer and multiple layer coating constructs are encompassed in the various embodiments of the present invention. | 10-15-2009 |
20090274741 | POLYMERS CONTAINING POLY(ESTER AMIDES) AND AGENTS FOR USE WITH MEDICAL ARTICLES AND METHODS OF FABRICATING THE SAME - Polymers containing poly(ester amides) and agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable substrate having a coating, and the coating contains a polymer comprising a polymeric product of a reaction comprising a polyol, a polycarboxylic acid, an amino acid and an agent. | 11-05-2009 |
20090297621 | Microparticles For The Treatment Of Disease - Microparticle-bioactive agent based treatments for local treatment of diseased tissues/organs are disclosed. | 12-03-2009 |
20090311301 | COATING CONSTRUCT CONTAINING POLY(VINYL ALCOHOL) - A method of forming a surface layer that includes a hydroxyl polymer on a substrate coating on a medical device is provided. | 12-17-2009 |
20090324671 | Poly(Amide) And Poly(Ester-Amide) Polymers And Drug Delivery Particles And Coatings Containing Same - The current invention relates to poly(amide) and poly(ester-amide) polymers, coatings including the polymers, and narrow polydispersity drug delivery particles including the polymers. | 12-31-2009 |
20100025894 | TUBE EXPANSION PROCESS FOR SEMICRYSTALLINE POLYMERS TO MAXIMIZE FRACTURE TOUGHNESS - Methods of fabricating a polymeric stent with improved fracture toughness including radial expansion of a polymer tube along its entire length at the same time and fabricating a stent from the expanded tube are disclosed herein. | 02-04-2010 |
20100222872 | Methods, Compositions and Devices for Treating Lesioned Sites Using Bioabsorbable Carriers - Methods and compositions for the sustained release of treatment agents to treat an occluded blood vessel and affected tissue and/or organs are disclosed. Porous or non-porous bioabsorbable glass, metal or ceramic bead, rod or fiber particles can be loaded with a treatment agent, and optionally an image-enhancing agent, and coated with a sustained-release coating for delivery to an occluded blood vessel and affected tissue and/or organs by a delivery device. Implantable medical devices manufactured with coatings including the particles or embedded within the medical device are additionally disclosed. | 09-02-2010 |
20100323019 | Microparticles for the treatment of disease - Microparticle-bioactive agent based treatments for local treatment of diseased tissues/organs are disclosed. | 12-23-2010 |
20110022163 | Implantable Medical Device Comprising Copolymer Of L-Lactide With Improved Fracture Toughness - The present invention relates to implantable medical devices comprising a L-lactide-constitutional unit-containing copolymer having a wt % percent crystallinity of 40% or less. | 01-27-2011 |
20110027188 | Methods, Compositions and Devices for Treating Lesioned Sites Using Bioabsorbable Carriers - An implantable medical device is disclosed having a plurality of smaller particles contained in a plurality of larger particles and configured to be released from the larger particles when the device is implanted in a patient. The smaller particles and the larger particles are made of bioabsorbable metal, glass or ceramic. A substance can be associated with the smaller particles. The larger particles can be embedded within at least a portion of the device. | 02-03-2011 |
20110027336 | COATINGS FOR IMPLANTABLE DEVICES COMPRISING POLYMERS OF LACTIC ACID AND METHODS FOR FABRICATING THE SAME - Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising polymers of lactic acid. | 02-03-2011 |
20110033517 | COATINGS FOR IMPLANTABLE MEDICAL DEVICES COMPRISING HYDROPHILIC SUBSTANCES AND METHODS FOR FABRICATING THE SAME - A segmented polyurethane and an amphiphilic random or block copolymer are disclosed. The segmented polyurethane and the amphiphilic random or block copolymer can be used for fabricating a coating for an implantable medical device such as a stent. | 02-10-2011 |
20110062638 | Controlling Crystalline Morphology Of A Bioabsorbable Stent - Methods to expand polymer tubing with desirable or optimum morphology and mechanical properties for stent manufacture and fabrication of a stent therefrom are disclosed. | 03-17-2011 |
20110270387 | Implantable Medical Devices Comprising Poly[L-Lactide-Co-(3,6-Dialkyl-1,4-Dioxane-2,5-Dione)] - This invention is directed to implantable medical device comprising a polymeric composition comprising poly[L-lactide-co-(3,6-dialkyl-1,4-dioxane-2,5-dione)], alone or as a blend with one or more polymers selected from the group consisting of poly(L-lactide) and poly(3,6-dialkyl-1,4-dioxane-2,5-dione). | 11-03-2011 |
20110278771 | TUBE EXPANSION PROCESSES AND SYSTEMS FOR SEMICRYSTALLINE POLYMERS TO MAXIMIZE FRACTURE TOUGHNESS - Methods of and systems for fabricating a polymeric stent with improved fracture toughness including radial expansion of a polymer tube along its entire length at the same time and fabricating a stent from the expanded tube are disclosed herein. | 11-17-2011 |
20110293675 | COATINGS OF ACRYLAMIDE-BASED COPOLYMERS - An implantable device including conjugate formed of an acrylamide-based copolymer and a bioactive agent is provided. | 12-01-2011 |
20110311596 | POLY(AMIDE) AND POLY(ESTER-AMIDE) POLYMERS AND DRUG DELIVERY PARTICLES AND COATINGS CONTAINING SAME - The current invention relates to poly(amide) and poly(ester-amide) polymers, coatings including the polymers, and narrow polydispersity drug delivery particles including the polymers. | 12-22-2011 |
20120034222 | Nitric Oxide Generating Medical Devices - Medical devices having a catalyst capable of catalyzing the generation of nitric oxide in vivo and methods of treating a vascular condition using the devices are provided. | 02-09-2012 |
20130023507 | HYALURONIC ACID BASED COPOLYMERS - Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof. | 01-24-2013 |
20130023508 | HYALURONIC ACID BASED COPOLYMERS - Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof. | 01-24-2013 |
20130023509 | HYALURONIC ACID BASED COPOLYMERS - Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof. | 01-24-2013 |
20130026681 | TUBE EXPANSION PROCESSES FOR SEMICRYSTALLINE POLYMERS TO MAXIMIZE FRACTURE TOUGHNESS - Methods for fabricating a polymeric stent with improved fracture toughness including radial expansion of a polymer tube and fabricating a stent from the expanded tube are disclosed. The polymer tube is disposed within a mold and may be heated with radiation. The heated tube radially expands within the mold. | 01-31-2013 |
20130041129 | Controlling Moisture In And Plasticization Of Bioresorbable Polymer For Melt Processing - Methods and systems for controlling the moisture content of biodegradable and bioresorbable polymer resin during extrusion above a lower limit that allows for plasticization of the polymer resin melt and below an upper limit to reduce or prevent molecular weight loss are disclosed. Methods are further disclosed involving plasticization of a polymer resin for feeding into an extruder with carbon dioxide and freon. | 02-14-2013 |
20130071449 | COATINGS OF ACRYLAMIDE-BASED COPOLYMERS - An implantable device including a conjugate formed of an acrylamide-based copolymer and a bioactive agent is provided. | 03-21-2013 |
20130087270 | Polyethylene glycol/poly(butylene terephthalate) copolymer coated devices including EVEROLIMUS - Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided. | 04-11-2013 |
20130116380 | COATINGS FOR IMPLANTABLE DEVICES COMPRISING POLY(HYDROXY-ALKANOATES) AND DIACID LINKAGES - Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings including block-polymers comprising at least one poly(hydroxyacid) or poly(hydroxy-alkanoate) block, at least one block of a biologically compatible polymer and at least one type of linking moiety. | 05-09-2013 |
20130123422 | COATINGS FOR IMPLANTABLE DEVICES COMPRISING POLY(HYDROXY-ALKANOATES) AND DIACID LINKAGES - Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings include block-polymers comprising at least one poly(hydroxyacid) or poly(hydroxy-alkanoate) block, at least one block of a biologically compatible polymer and at least one type of linking moiety. | 05-16-2013 |
20130142939 | Methods of Forming Coatings with a Crystalline or Partially Crystalline Drug for Implantable Medical Devices using Sonocrystallization - Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided. | 06-06-2013 |
20130149430 | Methods of forming coatings with a crystalline or partially crystalline drug for implantable medical devices using supercritical fluid assisted sorption - Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided. | 06-13-2013 |
20130149431 | Methods of Forming Coatings with a Crystalline or Partially Crystalline Drug for Implantable Medical Devices - Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided. | 06-13-2013 |
20130187313 | Controlling Crystalline Morphology of a Bioabsorbable Stent - Methods to expand polymer tubing with desirable or optimum morphology and mechanical properties for stem manufacture and fabrication of a stent therefrom are disclosed. | 07-25-2013 |
20130287833 | Nitric Oxide Generating Medical Devices - Medical devices having a catalyst capable of catalyzing the generation of nitric oxide in vivo and methods of treating a vascular condition using the devices are provided. | 10-31-2013 |
20140004250 | Methods of treatment of polymeric coatings for control of agent release rates | 01-02-2014 |
20140030422 | MODIFYING POLYMER PROPERTIES WITH PENETRANTS IN THE FABRICATION OF BIORESORBABLE SCAFFOLDS - Methods of fabricating a bioresorbable polymer scaffold are disclosed including a step of inducing crystallization in a bioresorbable polymer construct through exposure to a liquid penetrant. | 01-30-2014 |
20140046006 | IMPLANTABLE MEDICAL DEVICES FABRICATED FROM BRANCHED POLYMERS - Implantable medical devices fabricated from branched polymers are disclosed. | 02-13-2014 |
20140079743 | COATINGS OF ACRYLAMIDE-BASED COPOLYMERS - An implantable device including a conjugate formed of an acrylamide-based copolymer and a bioactive agent is provided. | 03-20-2014 |
20140081417 | IMPLANTABLE MEDICAL DEVICES FABRICATED FROM BRANCHED POLYMERS - Stent scaffolds comprising branched biocompatible polymers are disclosed. | 03-20-2014 |
20140100302 | COATINGS FOR IMPLANTABLE DEVICES COMPRISING POLY(HYDROXY-ALKANOATES) AND DIACID LINKAGES - Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings including block-polymers comprising at least one poly(hydroxyacid) or poly(hydroxy-alkanoate) block, at least one block of a biologically compatible polymer and at least one type of linking moiety. | 04-10-2014 |
20140107761 | Biodegradable stent with enhanced fracture toughness - Stents and methods of manufacturing a stents with enhanced fracture toughness are disclosed. | 04-17-2014 |
20140107762 | Biodegradable stent with enhanced fracture toughness - Stents and methods of manufacturing a stents with enhanced fracture toughness are disclosed. | 04-17-2014 |
20140114394 | Biodegradable stent with enhanced fracture toughness - Stents and methods of manufacturing a stents with enhanced fracture toughness are disclosed. | 04-24-2014 |
20140128959 | Biodegradable stent with enhanced fracture toughness - Stents and methods of manufacturing a stents with enhanced fracture toughness are disclosed. | 05-08-2014 |
20140221418 | HYALURONIC ACID BASED COPOLYMERS - Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof. | 08-07-2014 |
20140298675 | CONTROLLING MOISTURE IN AND PLASTICIZATION OF BIORESORBABLE POLYMER FOR MELT PROCESSING - Methods and systems for controlling the moisture content of biodegradable and bioresorbable polymer resin during extrusion above a lower limit that allows for plasticization of the polymer resin melt and below an upper limit to reduce or prevent molecular weight loss are disclosed. Methods are further disclosed involving plasticization of a polymer resin for feeding into an extruder with carbon dioxide and freon. | 10-09-2014 |
20140356519 | ELASTIN-BASED COPOLYMERS AND METHOD OF USING - A copolymer comprising a block of an elastin pentapeptide and method of making and using the copolymer are provided. | 12-04-2014 |
20140363563 | ELASTIN-BASED COPOLYMERS - A copolymer comprising a block of an elastin pentapeptide and method of making and using the copolymer are provided. | 12-11-2014 |
20140374963 | TUBE EXPANSION PROCESSES FOR SEMICRYSTALLINE POLYMERS TO MAXIMIZE FRACTURE TOUGHNESS - Methods for fabricating a polymeric stent with improved fracture toughness including radial expansion of a polymer tube and fabricating a stent from the expanded tube are disclosed. The polymer tube is disposed within a mold and may be heated with radiation. The heated tube radially expands within the mold. | 12-25-2014 |
20140377325 | COATINGS FOR IMPLANTABLE DEVICES COMPRISING POLYMERS OF LACTIC ACID AND METHODS FOR FABRICATING THE SAME - Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising polymers of lactic acid. | 12-25-2014 |