Patent application number | Description | Published |
20100002981 | Sensitive Emission Light Gathering and Flow Through Detection System - A method of detecting fluorescence/absorbance/luminescence from 24-well, 48-well, 96-well, 384-well and 1536-well microplates and other sample containers. The sample is pumped into a waveguide. The waveguide efficiently gathers and guides the emission light to the end of the waveguide. The emission light exits the ends of the waveguide and is focused into a detector. To minimize background caused by the excitation light used for fluorescence, the excitation illuminates the waveguides at 90 degrees. To facilitate reuse, the waveguide assembly can be configured to be washed by an appropriate wash solution. | 01-07-2010 |
20100181288 | Method of fabrication of micro- and nanofilters - Micro- and nanofilters have a wide range of applications in many fields, including medical diagnostics, drug delivery, medical implants, and hemodialysis. Some issues that limit commercial application of current nanofilters in medicine are low pore density, non-uniform pore size, and the use of materials that are not biocompatible. A method is described to fabricate high porosity polymer and diamond micro- and nanofilters producing smooth, uniform and straight pores of high aspect ratio. Pore size, density, and shape can be predetermined with a high degree of precision by masks and controlled etch. The method combines energetic neutral atom beam lithography and a mask. This technology allows etching polymeric materials in a clean, well-controlled, and charge-free environment, making it very suitable for fabricating nanofilters and other components for biomedical applications. | 07-22-2010 |
20100208256 | SENSITIVE EMISSION LIGHT GATHERING AND DETECTION SYSTEM - A luminometer is provided comprising a waveguide sample holder and one or more detectors. The waveguide sample holder may include a hollow region to hold the sample. The waveguide sample holder can be made of material that guides emission light to a bottom end of the waveguide sample holder. One or more detectors may be provided which detect the emission light coming out of the bottom of the waveguide sample holder. A fluorometer/photometer is also provided that comprises a waveguide sample holder, one or more excitation light sources, and one or more optical detectors. The waveguide sample holder has a hollow region to hold the sample. The excitation light is introduced at an angle or perpendicular to one surface of the waveguide sample holder. The waveguide sample holder is made of material that can guide emission light to the bottom end of the waveguide sample holder. There are one or more detectors that detect the emission light coming out of the bottom of the waveguide sample holder. | 08-19-2010 |
20100279322 | Direct detection of intracellular fluorescently tagged cells in solution - A method of detecting target cells and pathogens in a test sample concentrates to target cells in solution by filtering or capturing the target cells on a solid support. The target cells are tagged with a fluorescent dye and dispersed in a solution or suspension. The resulting solution or suspension are introduced to a fluorometer to specifically identify and quantitate the target cells. The target cells can be lysed or whole when introduced to the fluorometer. | 11-04-2010 |
20110039267 | Sample Preparation And Detection Of Analytes Using Silica Beads - This invention provides methods for concentration of analyte from biological sample, or various liquid samples and methods for identification of the analyte. The method includes providing silica beads conjugated with analyte recognition element for concentration of analyte from sample, packaging the beads into a cartridge, and attaching the cartridge to a sample holder. After the analyte concentration, additional steps can be implemented to identify the analyte to provide visual positive/negative, qualitative or quantitative results. Another exemplary embodiment of the present invention provides a system for concentration of analyte from biological sample or other various liquid samples using silica beads. According to an exemplary implementation, the system includes a cartridge comprising silica beads conjugated with analyte recognition element to concentrate at least one analyte from the sample, and a sample holder having the cartridge attached thereto. A sample is passed through the cartridge. | 02-17-2011 |
20120183946 | Fabrication of Microfilters and Nanofilters and Their Applications - Micro- and nanofilters with precision pore sizes and pore layout have applications in many fields including capturing circulating tumor cells and fetal cells in blood, water treatment, pathogen detection in water, etc. Methods to fabricate micro- and nanofilters not using track etching or reactive ion etching are provided, allowing easy fabrication of single layer or stack of films simultaneously, and/or stack of films on rolls. Microfilter can be made using one or more layers of material. Invention enables mass production of microfilters with lithographic quality at low cost. Isolation, enumeration and characterization of circulating tumor cells using microfilters provides (i) guides to cancer treatment selection and personalize dosage, (ii) low cost monitoring for treatment response, disease progression and recurrence, (iii) assessment of pharmacodynamic effects, (iv) information on mechanisms of resistance to therapy, and (v) cancer staging. Microfabrication methods are also applicable to fabrication of any free standing patterned polymeric films. | 07-19-2012 |
20130059308 | POLYMER MICROFILTERS AND METHODS OF MANUFACTURING THE SAME - A microfilter comprising a polymer layer formed from epoxy-based photo-definable dry film, and a plurality of apertures each extending through the polymer layer. A method of forming a microfilter is also disclosed. The method includes providing a first layer of epoxy-based photo-definable dry film disposed on a substrate, exposing the first layer to energy through a mask to form a pattern, defmed by the mask, in the first layer of dry film, forming, from the exposed first layer of dry film, a polymer layer having a plurality of apertures extending therethrough, the plurality of apertures having a distribution defined by the pattern, and removing the polymer layer from the substrate. | 03-07-2013 |
20130330721 | POLYMER MICROFILTRATION DEVICES, METHODS OF MANUFACTURING THE SAME AND THE USES OF THE MICROFILTRATION DEVICES - A microfilter comprising a polymer layer formed from photo-definable dry film, and a plurality of apertures each extending through the polymer layer. A microfilter comprising two or more polymer layers formed from photo-definable dry film, and a plurality of apertures or open areas each extending through the polymer layer. Methods of forming apertures in one or more layers of photo-definable dry film are also disclosed. Filter holder designs and methods appropriate to hold microfilters to collect the rare cells and to perform of assays in the filter holder are provided. Microfiltration chip designs and methods appropriate to collect the rare cells and to perform assays in the microfluidic chips are provided. The invention also describes the use of the microfilter, filter holder and microfilter chips to collect rare cells from body fluids and perform assays, and these rare cells can be used for medical and biological research applications. | 12-12-2013 |
20140302526 | ZAP-70 DETECTION IN CHRONIC LYMPHOCYTIC LEUKEMIA - Detection of ZAP-70 expression provides important information about disease progression and overall survival in patients with chronic lymphocytic leukemia (CLL). The invention provides methods for diagnosing CLL in a subject, as well as methods for clearly distinguishing CLL patients with aggressive form of the disease. A consistent number of B cells from patient blood is isolated and lysed to release all of the intracellular ZAP-70 protein. The released ZAP-70 protein is subsequently extracted by immunomagnetic separation followed by detection with fluorescence immunosandwich assay. The ZAP-70 fluorescence signal is measured with Signalyte™-II spectrofluorometer. The VeriZAP™ assay is a simple, reliable, and reproducible method for quantitative detection of ZAP-70 in patient leukemic cells, and can be used as a prognostic test to distinguish indolent versus aggressive CLL patients. | 10-09-2014 |
20140315295 | POLYMER MICROFILTERS, DEVICES COMPRISING THE SAME, METHODS OF MANUFACTURING THE SAME, AND USES THEREOF - A microfilter having a hydrophilic surface and suited for size-based capture and analysis of cells, such as circulating cancer cells, from whole blood and other human fluids is disclosed. The filter material is photo-definable, allowing the formation of precision pores by UV lithography. Exemplary embodiments provide a device that combines a microfilter with 3D nanotopography in culture scaffolds that mimic the 3D in vivo environment to better facilitate growth of captured cells. | 10-23-2014 |
20140322743 | POLYMER MICROFILTRATION DEVICES, METHODS OF MANUFACTURING THE SAME AND THE USES OF THE MICROFILTRATION DEVICES - A microfilter comprising a polymer layer formed from epoxy-based photo-definable dry film, and a plurality of apertures each extending through the polymer layer. A microfilter comprising two or more polymer layers formed from epoxy-based photo-definable dry film, and a plurality of apertures or open areas each extending through the polymer layer. A method of forming a microfilter is also disclosed. The method includes providing a first layer of epoxy-based photo-definable dry film disposed on a substrate, exposing the first layer to energy through a mask to form a pattern, defined by the mask, in the first layer of dry film, forming, from the exposed first layer of dry film, a polymer layer having a plurality of apertures extending therethrough, the plurality of apertures having a distribution defined by the pattern, and removing the polymer layer from the substrate. Unique filter holder designs and methods appropriate to hold microfilters to collect the rare cells and allow performing assays in the filter holder are provided. The invention also describes the use of the microfilter and filter holder to collect rare cells from body fluids and perform assays. Rare cells collected on the microfilter in accordance with embodiments of the present invention can be used for medical and biological research applications. | 10-30-2014 |
20160021872 | URINE PRESERVATIVE REAGENT FOR MICROFILTRATION - A preservative reagent for urine is disclosed that increases the stability of cells, such as tumor cells, in urine for a period of several weeks. The preservative reagent comprises polyethylene glycol (PEG), ethanol, paraformaldehyde (PFA), and ethylenediaminetetraacetic acid (EDTA), and optionally pH stabilizing reagents. | 01-28-2016 |
Patent application number | Description | Published |
20100284323 | HIGHLY INTEGRATED VERY SMALL APERTURE TERMINAL (VSAT) APPARATUS AND METHOD - A method, and a VSAT capable of being configured for such a method, of configuring a VSAT, the steps of which are setting, while an outdoor unit of the VSAT is at a configuration location, a maximum value of the adjustable gain of the up-converting device and transmitting, from an operating location that is separate from the configuration location, transmission signals to the satellite at the transmission frequency and with a gain value of at most the maximum value of the adjustable gain set at the configuration location. | 11-11-2010 |
20130128805 | HIGHLY INTEGRATED VERY SMALL APERTURE TERMINAL (VSAT) APPARATUS AND METHOD - A method, and a VSAT capable of being configured for such a method, of configuring a VSAT, the steps of which are setting, while an outdoor unit of the VSAT is at a configuration location, a maximum value of the adjustable gain of the up-converting device and transmitting, from an operating location that is separate from the configuration location, transmission signals to the satellite at the transmission frequency and with a gain value of at most the maximum value of the adjustable gain set at the configuration location. | 05-23-2013 |
20150358051 | HIGHLY INTEGRATED VERY SMALL APERTURE TERMINAL (VSAT) APPARATUS AND METHOD - A method, and a VSAT capable of being configured for such a method, of configuring a VSAT, the steps of which are setting, while an outdoor unit of the VSAT is at a configuration location, a maximum value of the adjustable gain of the up-converting device and transmitting, from an operating location that is separate from the configuration location, transmission signals to the satellite at the transmission frequency and with a gain value of at most the maximum value of the adjustable gain set at the configuration location. | 12-10-2015 |
Patent application number | Description | Published |
20120039956 | DRY STORAGE STABILIZING COMPOSITION FOR BIOLOGICAL MATERIALS - The present invention includes compositions and drying methods for preserving sensitive bioactive materials, such as peptides, proteins, hormones, nucleic acids, antibodies, drugs vaccines, yeast, bacteria (probiotic or otherwise), viruses and/or cell suspensions, in storage. The compositions include a carbohydrates component and a glass enhancer component, wherein the carbohydrate component includes a mixture of di-, oligo- and polysaccharides and the glass enhancer includes ions of organic acid and protein hydrolysates. The composition is prepared by dispersing all the solid components in a solution and then snap-frozen to form small beads, strings or droplets. The preferred drying method of the frozen beads, strings or droplets is initiated by a short purging and structure stabilizing step of the frozen particles under a vacuum pressure of less than <2000 mTORR followed by a primary drying step under vacuum pressure of more than >2000 mTORR and at a desired temperature. During the secondary and final drying step of the material a full vacuum pressure and elevated temperature are applied, to achieve a final desirable water activity of the dry material. | 02-16-2012 |
20130296165 | Stabilizing Composition for Biological Materials - Dry stabilizing compositions for bioactive materials include sugars and hydrolyzed proteins, and may be formed into tablets or other forms providing enhanced stability for the bioactive material. Compositions containing the bioactive materials may be produced by a method that includes (a) combining the bioactive material with other ingredients in an aqueous solvent to form a viscous slurry; (b) snap-freezing the slurry in liquid nitrogen to form solid frozen particles, beads, droplets or strings; (c) primary drying by water removal under vacuum of the product of step (b) while maintaining it at a temperature above its freezing temperature; and (d) secondary drying of the product of step (c) at maximum vacuum and a temperature of 20° C. or higher for a time sufficient to reduce the water activity to below 0.3 Aw. | 11-07-2013 |
20140271605 | STABLE BIOACTIVE SUBSTANCES AND METHODS OF MAKING - The present invention relates to stable bioactive substances and preparation thereof. A preparation method includes dissolving a bioactive material in a solution substantially free of solutes to make a bioactive solution, adsorbing the bioactive solution onto dry polysaccharide particles to make bioactive loaded polysaccharide particles, and drying the bioactive loaded polysaccharide particles. | 09-18-2014 |
Patent application number | Description | Published |
20100160247 | Synthesis of deuterated morpholine derivatives - The present invention is directed to a process for preparing a 2,26,6-d | 06-24-2010 |
20110200644 | DHA Ester Emulsions - The present invention is directed to an emulsion comprising an emulsifier, an isotonic agent and a docosahexaenoic acid ethyl ester (DHA-EE) wherein the emulsion is substantially free of eicosapentaenoic acid (EPA) and is suitable for parenteral administration. | 08-18-2011 |
20110200645 | DHA Free Fatty Acid Emulsions - The present invention is directed to an emulsion comprising an emulsifier, an isotonic agent and a docosahexaenoic acid free fatty acid (DHA-FFA) wherein the emulsion is substantially free of eicosapentaenoic acid (EPA) and is suitable for parenteral administration. | 08-18-2011 |
20110206741 | DHA Triglyceride Emulsions - The present invention is directed to an emulsion comprising an emulsifier, an isotonic agent and a docosahexaenoic acid triglyceride (DHA-TG) wherein the emulsion is substantially free of eicosapentaenoic acid (EPA) and is suitable for parenteral administration. | 08-25-2011 |
20130281456 | SYNTHESIS OF DEUTERATED MORPHOLINE DERIVATIVES - The present invention is directed to a process for preparing a 2,26,6-d | 10-24-2013 |
20130316061 | Oxidatively stable polyunsaturated fatty acid containing oil - An oil comprising (i) at least 30 wt. % of one or more polyunsaturated fatty acids having at least 4 double bonds; (ii) at least one first antioxidant; and (iii) less than about 1000 ppm lecithin. The oil may comprise less than about 750 ppm of a second antioxidant chosen from an ascorbic acid derivative. | 11-28-2013 |
20150017304 | OXIDATIVELY STABLE POLYUNSATURATED FATTY ACID CONTAINING OIL - An oil comprising (i) at least 30 wt. % of one or more polyunsaturated fatty acids having at least 4 double bonds; (ii) at least one first antioxidant; and (iii) less than about 1000 ppm lecithin. The oil may comprise less than about 750 ppm of a second antioxidant chosen from an ascorbic acid derivative. | 01-15-2015 |
20150099714 | SYNTHESIS OF DEUTERATED MORPHOLINE DERIVATIVES - The present invention is directed to a process for preparing a 2,26,6-d | 04-09-2015 |
Patent application number | Description | Published |
20150242568 | NETWORK-BASED SYSTEMS AND METHODS FOR PROCESSING HEALTHCARE INFORMATION DIRECTLY FROM PROVIDERS - Networks and methods include or use a computer hardware processor to manage healthcare information between healthcare sources and providing subscribers. Subscriber requests and healthcare information about patients are used in the networks and methods to provide only responsive content to subscribers. Networks and methods screen healthcare with criteria in the subscriber requests, and only when the information matches the criteria, provides a deliverable based on the healthcare information, in desired format and fashion, to the subscriber associated with the matching criteria. Systems and methods are configured to receive healthcare information directly from providers themselves, as well as from other sources. The healthcare information can be in several formats recognizable for processing and selective forwarding, including CCDA-type summary of care documents sent over the Internet, such as via Direct protocol email. | 08-27-2015 |
20150242569 | NETWORK-BASED SYSTEMS AND METHODS FOR META-ANALYSIS OF HEALTHCARE INFORMATION - Networks and methods include or use a computer hardware processor to manage healthcare information between healthcare sources and providing subscribers. Subscriber requests and healthcare information about patients are used in the networks and methods to provide only responsive content to subscribers. Networks and methods screen healthcare with criteria in the subscriber requests, and only when the information matches the criteria, provides a deliverable based on the healthcare information, in desired format and fashion, to the subscriber associated with the matching criteria. Systems and methods also perform meta-analysis on received healthcare information itself. The meta-analysis is used to correct or enhance the deliverable with things like typographical correction, auto-subscribe/unsubscribe, historical healthcare analysis, addition of relevant alert information, and other conditioning. | 08-27-2015 |
20150242574 | NETWORK-BASED SYSTEMS AND METHODS FOR EFFICIENT FILTERING AND ROUTING OF HEALTHCARE INFORMATION - Networks and methods include or use a computer hardware processor to manage healthcare information between healthcare sources and providing subscribers. Subscriber requests and healthcare information about patients are used in the networks and methods to provide only responsive content to subscribers. Networks and methods screen healthcare with criteria in the subscriber requests, and only when the information matches the criteria, provides a deliverable based on the healthcare information, in desired format and fashion, to the subscriber associated with the matching criteria. Systems and methods perform one or multiple different types of comparisons between received provider actions and subscribing provider requests, including targeted screenings that initially filter out non-responsive information and call out a particular subscriber's parameters to be used in handling the data, as well as comprehensive associations that look at all related healthcare information vis-à-vis any subscriber's time, manner, condition, format requirements for notifying the subscriber that the information. | 08-27-2015 |
Patent application number | Description | Published |
20130246081 | Systems and Methods for Supplementing Patient and Provider Interactions to Increase Patient Adherence - The present invention relates generally to a method of supplementing an electronic prescription issued by a health care provider, the method comprising: a) receiving, on a computer apparatus, electronic prescription data generated by a health care provider for a patient for a prescribed substance; b) the computer apparatus determining, from a plurality of available supplemental programs stored on one or more databases, supplemental programs for which the patient is eligible based on the electronic prescription data; c) presenting to the health care provider, in a display device, a list of the eligible supplemental programs, each of the eligible supplemental programs being selectable and de-selectable by the health care provider in the display device; and d) the computer apparatus activating each supplemental program from the plurality of available supplemental programs that have been selected and confirmed by the health care provider in the display device. | 09-19-2013 |
20130246082 | Systems and Methods for Supplementing Patient and Provider Interactions to Increase Patient Adherence Specifically Using Combined Educational Coupons and Tailored Educational Documents and Services - The present invention relates generally to a method of determining effectiveness of supplemental programs on patient adherence that includes: a) a computer apparatus assigning to each of a plurality of cohorts a different permutation of supplemental programs available for one or more prescribed substances, wherein each of the plurality of cohorts is a sub-set of a plurality of health care providers; b) receiving, on the computer apparatus, data relating to an electronic prescription of the one or more prescribed substances generated by a health care provider of the plurality of health care providers; and c) the computer, apparatus activating the supplemental programs associated with the cohort to which the health care provider belongs. | 09-19-2013 |
20130311205 | SYSTEM AND METHOD FOR INCREASING PATIENT ADHERENCE TO MEDICATION TREATMENT REGIMENS - A system and method for increasing patient adherence to following medication treatment regimens. An adherence data processing and communication system generates and displays medication adherence data based on historical medication information. The system is linked to other systems involved with electronic ordering and filling of prescriptions, such as electronic prescription and pharmacy systems all connected by suitable wired and/or wireless communication protocols including the Internet. In one embodiment, the adherence data is displayed in the form of an interactive report card which provides a user with adherence metrics in both summary and more detailed formats for prescription medications taken by the patient. A related method executed by the data processing and communication system is disclosed. | 11-21-2013 |
20130317839 | SYSTEM AND METHOD FOR INCREASING PATIENT ADHERENCE TO MEDICATION TREATMENT REGIMENS - A system and method for increasing patient adherence to following medication treatment regimens. An adherence data processing and communication system generates and displays medication adherence data based on historical medication information. The system is linked to other systems involved with electronic ordering and filling of prescriptions, such as electronic prescription and pharmacy systems all connected by suitable wired and/or wireless communication protocols including the Internet. In one embodiment, the adherence data is displayed in the form of an interactive report card which provides a user with adherence metrics in both summary and more detailed formats for prescription medications taken by the patient. A related method executed by the data processing and communication system is disclosed. | 11-28-2013 |
20130317840 | SYSTEM AND METHOD FOR INCREASING PATIENT ADHERENCE TO MEDICATION TREATMENT REGIMENS - A system and method for increasing patient adherence to following medication treatment regimens. An adherence data processing and communication system generates and displays medication adherence data based on historical medication information. The system is linked to other systems involved with electronic ordering and filling of prescriptions, such as electronic prescription and pharmacy systems all connected by suitable wired and/or wireless communication protocols including the Internet. In one embodiment, the adherence data is displayed in the form of an interactive report card which provides a user with adherence metrics in both summary and more detailed formats for prescription medications taken by the patient. A related method executed by the data processing and communication system is disclosed. | 11-28-2013 |
20150310176 | HEALTHCARE EVENT RESPONSE AND COMMUNICATION CENTER - The present teaching relates to a Healthcare Event Response and Communication Center. In one example, a healthcare message is received. The healthcare message is processed to automatically identify one or more healthcare events. For each identified healthcare event, one or more responsive entities that are configured to be responsive to the healthcare event are identified. Each responsive entity is associated with one or more healthcare workflows that are configured to receive the healthcare event. Each identified healthcare event is provided in real-time to each of the one or more responsive healthcare workflows with respect to each responsive entity. | 10-29-2015 |
20160063239 | METHOD AND SYSTEM FOR INTEROPERABLE IDENTITY AND INTEROPERABLE CREDENTIALS - The present teaching relates to generating an identifier for a person. In one example, an actual name of the person is received. The identity of the person that is associated with the actual name of the person is proved at a pre-determined level of assurance (LOA) required by an identity management system. When the identity of the person has been proved, a peripheral name is solicited from the person. An identifier that includes the actual name and the peripheral name of the person is created. Whether the identifier is unique is determined. The steps of soliciting, creating, and determining are repeated until the identifier is unique. The peripheral name is associated with the person. The identifier is associated with the person. | 03-03-2016 |
20160065552 | METHOD AND SYSTEM FOR INTEROPERABLE IDENTITY AND INTEROPERABLE CREDENTIALS - Method, system, and programs for interoperable identity and interoperable credentials. In one example, an authentication request is received. The authentication request originated from an online user in connection with an application having a first LOA. The authentication request includes the online user's input. A digital identity is searched based on the online user's input. A GUID associated with the digital identity is obtained when the digital identity is found. One or more credentials that are bound to the GUID at the first LOA or a higher LOA are provided. A selection of at least one credential is received. Information of the selected credential that includes a credential verification service capable of verifying the selected credential is received. Verification of the selected credential of the online user based on the GUID is requested. A verification response is received. The online user is authenticated at the first LOA when the verification response indicates that the selected credential is successfully verified. | 03-03-2016 |
20160065579 | METHOD AND SYSTEM FOR INTEROPERABLE IDENTITY AND INTEROPERABLE CREDENTIALS - The present teaching relates to identity management. In one example, a trusted connector is instantiated in the enterprise system behind a security. The trusted connector is configured to communicate with the private resource via a communication protocol. Upon being triggered by the external system, a secure communication channel is established between the external system and the trusted connector. A request is received from the external source at the trusted connector through the secure communication channel. The request is interpreted for communicating with the private resource. The interpreted request is sent to the private resource. A response is received from the private resource. The response from the private resource is interpreted for communicating with the external system. The interpreted response is sent to the external system through the secure communication channel. | 03-03-2016 |