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Tang, MA

Aaron Tang, Somerville, MA US

Patent application numberDescriptionPublished
20090300511SYSTEM AND METHOD FOR STREAMLINING USER INTERACTION WITH ELECTRONIC CONTENT - Various aspects and embodiments are directed to a graphical user interface that organizes interface elements into views of computer content for presentation to a user. Different views of are used to provide an interface that is responsive to configurations of the device and responsive to activity being performed by the user. Aspects include permitting the user to transition the device from one configuration to another during its use, for example from easel to laptop modes. Further the elements that comprise the graphical user interface are configured to present a summarized view of available actions and content, in order to simplify user interaction. The different views present different organizations of the interface elements and in some example display only certain ones of the modes of content in order to reduce the number of options a user must navigate to accomplish an objective. According to another aspect, methods and systems for streamlining user interaction with computer content are provided. In some embodiments, streamlining includes pre-configuring a user device based on received information. Other embodiments include presenting consistent visual representations used to navigated to views that present computer content.12-03-2009
20090303676SYSTEM AND METHOD FOR STREAMLINING USER INTERACTION WITH ELECTRONIC CONTENT - Various aspects and embodiments are directed to a graphical user interface that organizes interface elements into views of computer content for presentation to a user. Different views of are used to provide an interface that is responsive to configurations of the device and responsive to activity being performed by the user. Aspects include permitting the user to transition the device from one configuration to another during its use, for example from easel to laptop modes. Further the elements that comprise the graphical user interface are configured to present a summarized view of available actions and content, in order to simplify user interaction. The different views present different organizations of the interface elements and in some example display only certain ones of the modes of content in order to reduce the number of options a user must navigate to accomplish an objective. According to another aspect, methods and systems for streamlining user interaction with computer content are provided. In some embodiments, streamlining includes pre-configuring a user device based on received information. Other embodiments include presenting consistent visual representations used to navigated to views that present computer content.12-10-2009
20090322790SYSTEM AND METHOD FOR STREAMLINING USER INTERACTION WITH ELECTRONIC CONTENT - Various aspects and embodiments are directed to a graphical user interface that organizes interface elements into views of computer content for presentation to a user. Different views of are used to provide an interface that is responsive to configurations of the device and responsive to activity being performed by the user. Aspects include permitting the user to transition the device from one configuration to another during its use, for example from easel to laptop modes. Further the elements that comprise the graphical user interface are configured to present a summarized view of available actions and content, in order to simplify user interaction. The different views present different organizations of the interface elements and in some example display only certain ones of the modes of content in order to reduce the number of options a user must navigate to accomplish an objective. According to another aspect, methods and systems for streamlining user interaction with computer content are provided. In some embodiments, streamlining includes pre-configuring a user device based on received information. Other embodiments include presenting consistent visual representations used to navigated to views that present computer content.12-31-2009
20100174993METHOD AND APPARATUS FOR MANAGING DIGITAL MEDIA CONTENT - Various aspects and embodiments are directed to a streamlined computer device and a graphical user interface that organizes interface elements into views of computer content for presentation to a user. Various views of digital media content permits users to easily and efficiently access various digital media content. Different views are used to provide an interface that is responsive to configurations of the device and responsive to activity being performed by the user. Aspects include permitting the user to maintain and manage digital media content libraries. According to some embodiments, the libraries comprise user digital media content and references digital media content. Functionality provided to a user can be tailored to the type of content displayed, accessed and/or managed. According to various aspects, methods and systems are provided for accessing and managing digital media libraries on a streamlined computing device with a plurality selectable I/O profiles. According to some embodiments, the methods may include displaying a GUI on a device, wherein the GUI comprises at least a plurality of views of digital media content, providing for transition between the plurality of views in response to selection of an I/O profile and in response to activation of a view selector component by a user, executing an association with the at least one of the plurality of visual representations with digital media content in response to selection, transitioning a display on the computing device to a view of the digital media content, and providing for display of user digital media content and referenced digital media content in the view of the digital media content.07-08-2010
20110279354COMPUTER WITH TV MODE - According to one aspect, embodiments of the invention provide a method comprising acts of providing an interface in the computer system adapted to be connected to an external display device and providing a controller in the computer system. The controller may be adapted to transmit output display signals to the external display device, wherein the output display signals are configured to generate a user interface, receive, from the external display device, external display device identification information, determine whether the external display device was previously connected to the computer system; and in response to determining that the external display device was previously connected to the computer system, automatically configure a layout of the user interface to display within a previously defined display area of the external display device and automatically compensate the layout of the user interface for a previously defined overscan region of the external display device.11-17-2011
20110279376REMOTE CONTROL TO OPERATE COMPUTER SYSTEM - According to one aspect, embodiments of the invention provide a remote control comprising a housing comprising a first and second housing portion, wherein the first housing portion is coupled to the second housing portion and is configurable in at least two positions, a touchpad, a keypad, a processor configured to receive control signals from the touch pad and the keypad, and an RF transmitter configured to transmit signals from the processor to the computer system, wherein, in a first configuration of the remote control, the first housing portion is configured to be manipulated to a first position and the remote control is configured to operate in a first mode of operation, and wherein, in a second configuration of the remote control, the first housing portion is configured to be manipulated to a second position, and wherein the remote control is configured to operate in a second mode of operation.11-17-2011
20110283314CONFIGURABLE COMPUTER SYSTEM - According to one aspect, embodiments of the invention provide a computer system comprising a base station having a communication interface adapted to communicate with an external network, an external display device configured to receive output display signals from the base station, a user interface displayed on the external display device and generated in response to the output display signals, wherein the user interface is selectively configurable in one of a plurality of modes of content, and a remote control configured to interact with the user interface displayed by the external display device, wherein the remote control is selectively operable in at least two configurations and wherein the selectively operable remote is configured to permit a user to select for display on the external display device one of the plurality of modes of content of the user interface based on the selected configuration of the remote control.11-17-2011
20120098919VIDEO INTEGRATION - According to one aspect, a web optimized user device is provided. The web optimized device reduces complexity and facilitates interaction with web-based services and content. The web optimized device can be configured without a hard drive, facilitating integration of web-based services into a computing experience. The web optimized device presents a user interface that integrates video chat functionality into every aspect of the computer content accessed. In particular, a display manager manages the user interface presented and integrates video chat displays and features into the content displays in a content and/or context aware manner. These displays permit a user to intuitively interact with the video chat content and features while the user changes content, for example, web-based services, web-based applications, and other media content, without interruption of or interference from the video chat content.04-26-2012
20120098920VIDEO INTEGRATION - According to one aspect, a web optimized user device is provided. The web optimized device reduces complexity and facilitates interaction with web-based services and content. The web optimized device can be configured without a hard drive, facilitating integration of web-based services into a computing experience. The web optimized device presents a user interface that integrates video chat functionality into every aspect of the computer content accessed. In particular, a display manager manages the user interface presented and integrates video chat displays and features into the content displays in a content and/or context aware manner. These displays permit a user to intuitively interact with the video chat content and features while the user changes content, for example, web-based services, web-based applications, and other media content, without interruption of or interference from the video chat content.04-26-2012
20120098922VIDEO INTEGRATION - According to one aspect, a web optimized user device is provided. The web optimized device reduces complexity and facilitates interaction with web-based services and content. The web optimized device can be configured without a hard drive, facilitating integration of web-based services into a computing experience. The web optimized device presents a user interface that integrates video chat functionality into every aspect of the computer content accessed. In particular, a display manager manages the user interface presented and integrates video chat displays and features into the content displays in a content and/or context aware manner. These displays permit a user to intuitively interact with the video chat content and features while the user changes content, for example, web-based services, web-based applications, and other media content, without interruption of or interference from the video chat content.04-26-2012
20120102403VIDEO INTEGRATION - According to one aspect, a web optimized user device is provided. The web optimized device reduces complexity and facilitates interaction with web-based services and content. The web optimized device can be configured without a hard drive, facilitating integration of web-based services into a computing experience. The web optimized device presents a user interface that integrates video chat functionality into every aspect of the computer content accessed. In particular, a display manager manages the user interface presented and integrates video chat displays and features into the content displays in a content and/or context aware manner. These displays permit a user to intuitively interact with the video chat content and features while the user changes content, for example, web-based services, web-based applications, and other media content, without interruption of or interference from the video chat content.04-26-2012
20140282263METHOD AND APPARATUS FOR MANAGING DIGITAL MEDIA CONTENT - Various aspects and embodiments are directed to a streamlined computer device and a graphical user interface that organizes interface elements into views of computer content for presentation to a user. Various views of digital media content permits users to easily and efficiently access various digital media content. Different views are used to provide an interface that is responsive to configurations of the device and responsive to activity being performed by the user. Aspects include permitting the user to maintain and manage digital media content libraries. According to some embodiments, the libraries comprise user digital media content and references digital media content. Functionality provided to a user can be tailored to the type of content displayed, accessed and/or managed. According to various aspects, methods and systems are provided for accessing and managing digital media libraries on a streamlined computing device with a plurality selectable I/O profiles.09-18-2014
20150029298VIDEO INTEGRATION - According to one aspect, a web optimized user device is provided. The web optimized device reduces complexity and facilitates interaction with web-based services and content. The web optimized device can be configured without a hard drive, facilitating integration of web-based services into a computing experience. The web optimized device presents a user interface that integrates video chat functionality into every aspect of the computer content accessed. In particular, a display manager manages the user interface presented and integrates video chat displays and features into the content displays in a content and/or context aware manner. These displays permit a user to intuitively interact with the video chat content and features while the user changes content, for example, web-based services, web-based applications, and other media content, without interruption of or interference from the video chat content.01-29-2015
20150277688SYSTEM AND METHOD FOR STREAMLINING USER INTERACTION WITH ELECTRONIC CONTENT - Various aspects and embodiments are directed to a graphical user interface that organizes interface elements into views of computer content for presentation to a user. Different views of are used to provide an interface that is responsive to configurations of the device and activities performed by the user. Aspects include permitting the user to transition the device from one configuration to another during its use. The elements that comprise the graphical user interface are configured to present a summarized view of available actions and content to simplify user interaction. The different views present different organizations of the interface elements and in some examples display only to certain modes of content in order to reduce the number of options a user must navigate. Methods and systems for streamlining user interaction with computer content are also provided. Streamlining includes, for example, pre-configuring a user device based on received information.10-01-2015

Patent applications by Aaron Tang, Somerville, MA US

Aaron Tang, Boston, MA US

Patent application numberDescriptionPublished
20120240060METHOD AND APPARATUS FOR PUBLIC COMPUTING - Provided are systems and methods for configuring a portable computer for transient use by a plurality of guests at a selected location. According to some embodiments, the system and methods include displaying a first selection of content on a display screen of the portable computer, initiating a first session responsive to a first guest accessing the portable computer via a user interface of the portable computer, creating a first guest profile responsive to the first session being initiated, displaying a second selection of content on the display screen during the first session, the second selection of content comprising more available content than the first selection of content, terminating the first session responsive to one of a termination action taken by the first guest and expiration of a time-out period, and erasing history of the first session on the portable computer responsive to termination of the first session.09-20-2012
20120271666METHOD AND APPARATUS FOR PROVIDING CONTEXTUAL SERVICES - Provided are systems and methods for contextually providing services via a portable computer at a selected location. According to some embodiments, the systems and methods include processes for determining location-specific information about the selected location, determining status information about a user of the portable computer interface, and displaying an available service to the user on a display screen of the portable computer, the available service being selected based on the location-specific information and the status information, configuring a portable computer for transient use by a plurality of guests at a selected location.10-25-2012

Aaron Sung-Lien Tang, Boston, MA US

Patent application numberDescriptionPublished
20130157372WASTE RAMP FOR REAGENT CARDS - An automated analyzer for reagent cards having a leading end, a trailing end and a length between the leading end and the trailing end comprises a travel surface assembly having a card travel surface and an edge. A test analyzing mechanism is adjacent to the travel surface, and a waste receptacle is adjacent to the edge below the travel surface. The waste receptacle has a side and a waste cavity. A ramp member positioned below the travel surface has an end and a sloped surface, and is movable between an extended position where the sloped surface extends into the waste cavity, and a retracted position where the end is spaced from the side a distance greater than the length of the reagent card. A moving mechanism operably coupled with the ramp member is configured to move the ramp member between the extended position and the retracted position.06-20-2013

Benjamin C. Tang, Cambridge, MA US

Patent application numberDescriptionPublished
20150320837INSULIN DERIVATIVES FOR DIABETES TREATMENT - Compounds, compositions, and methods for “smart” delivery of a therapeutic, prophylactic or diagnostic agent, such as glucose-mediated delivery of insulin through glucose-sensing insulin derivatives, are provided. The insulin derivatives bind serum albumin or agglomerate in vivo. The insulin derivatives effectively dissociate to release insulin in a hyperglycemic condition, where the complexation of glucose to a glucose-sensing element alters properties of the insulin derivative leading to the dissociation. The compounds, compositions, and methods provide a delivery strategy for both self-regulated and long-term diabetes management.11-12-2015

Chung Yiu Jonathan Tang, Boston, MA US

Patent application numberDescriptionPublished
20130230863Target Molecules for Transcriptional Control Systems - The invention provides systems and methods for transcriptional control which employ target molecules.09-05-2013
20150096066TARGET MOLECULES FOR TRANSCRIPTIONAL CONTROL SYSTEMS - The invention provides systems to control gene expression or activity using target molecules.04-02-2015

Dalin Tang, Shrewsbury, MA US

Patent application numberDescriptionPublished
20080319308PATIENT-SPECIFIC IMAGE-BASED COMPUTATIONAL MODELING AND TECHNIQUES FOR HUMAN HEART SURGERY OPTIMIZATION - A method for determining cardiac status comprises for a given patient, constructing a patient-specific, three-dimensional, computational model of the patient's heart; and executing the constructed computational model, said executing generating a quantitative analysis of cardiac function. A method of performing cardiac surgeries comprises: a) assessing surgical options based on a patient-specific, three-dimensional, computational model of a patient's heart; and b) performing surgery based on one or more of the surgical options. A computer system comprises: a) a data source containing data of a patient's heart; b) a modeler coupled to receive data from the data source, the modeler generating a patient-specific, three-dimensional, computational model of the heart based on the heart data; and c) a processor routine for computationally providing information about a certain cardiac function using the three-dimensional heart model and for applying computational, quantitative analysis of the cardiac function, wherein the quantitative analysis of the cardiac function provides an assessment for surgical options, optimizing surgical techniques, or predicting outcomes.12-25-2008
20110295579AUTOMATIC VASCULAR MODEL GENERATION BASED ON FLUID-STRUCTURE INTERACTIONS (FSI) - A computer system and method are disclosed for automatically generating a vascular model of a blood vessel to support, for example, identification of mechanical factors corresponding to the blood vessel. The method includes interpolating data points corresponding to a contour of the blood vessel; generating a structural model representing three-dimensional structural characteristics of the blood vessel based on interpolated contours; generating a fluid model representing three-dimensional characteristics of fluid flow within the vessel; and generating a vascular model based on the structural model and the fluid model. The method may also include performing a mechanical analysis of the vascular model to identify a mechanical factor associated with the vessel, for example, a factor associated with a potential plaque rupture within the vessel. Embodiments of the invention are applicable to the diagnosis, assessment, or treatment of cardiovascular diseases.12-01-2011

Patent applications by Dalin Tang, Shrewsbury, MA US

Datong Tang, Watertown, MA US

Patent application numberDescriptionPublished
20080242865PROCESSES FOR THE PREPARATION OF HYDROXYLAMINES - The present invention relates generally to novel methods for the synthesis of O-(6-pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine which is an essential reagent in the synthesis of one of the bridged erythromycin derivatives and their respective pharmaceutically acceptable salts in PCT Application WO 03/097659 A1. In particular, the present invention relates to processes and intermediates for the preparation of a compound of formula (Ia):10-02-2008

Patent applications by Datong Tang, Watertown, MA US

Guiliang Tang, Worcester, MA US

Patent application numberDescriptionPublished
20080318896Methods and Compositions for Controlling of Efficacy of RNA Silencing - Based at least in part on an understanding of the mechanisms by which small RNAs (e.g., naturally-occurring miRNAs) mediate RNA silencing in plants, rules have been established for determining, for example, the degree of complementarity required between an RNAi-mediating agent and its target, i.e., whether mismatches are tolerated, the number of mismatches tolerated, the effect of the position of the mismatches, etc. Such rules are useful, in particular, in the design of improved RNAi-mediating agents which allow for more exact control of the efficacy of RNA silencing.12-25-2008
20090098614Methods and Compositions for controlling Efficacy of RNA Silencing - Based at least in part on an understanding of the mechanisms by which small RNAs (e.g., naturally-occurring miRNAs) mediate RNA silencing in plants, rules have been established for determining, for example, the degree of complementarity required between an RNAi-mediating agent and its target, i.e., whether mismatches are tolerated, the number of mismatches tolerated, the effect of the position of the mismatches, etc. Such rules are useful, in particular, in the design of improved RNAi-mediating agents which allow for more exact control of the efficacy of RNA silencing.04-16-2009
20100317105Methods and compositions for controlling efficacy of RNA silencing - Based at least in part on an understanding of the mechanisms by which small RNAs (e.g., naturally-occurring miRNAs) mediate RNA silencing in plants, rules have been established for determining, for example, the degree of complementarity required between an RNAi-mediating agent and its target, i.e., whether mismatches are tolerated, the number of mismatches tolerated, the effect of the position of the mismatches, etc. Such rules are useful, in particular, in the design of improved RNAi-mediating agents which allow for more exact control of the efficacy of RNA silencing.12-16-2010
20110152347Methods and compositions for controlling efficacy of RNA silencing - Based at least in part on an understanding of the mechanisms by which small RNAs (e.g., naturally-occurring miRNAs) mediate RNA silencing in plants, rules have been established for determining, for example, the degree of complementarity required between an RNAi-mediating agent and its target, i.e., whether mismatches are tolerated, the number of mismatches tolerated, the effect of the position of the mismatches, etc. Such rules are useful, in particular, in the design of improved RNAi-mediating agents which allow for more exact control of the efficacy of RNA silencing.06-23-2011
20140163084METHODS AND COMPOSITIONS FOR CONTROLLING EFFICACY OF RNA SILENCING - Based at least in part on an understanding of the mechanisms by which small RNAs (e.g., naturally-occurring miRNAs) mediate RNA silencing in plants, rules have been established for determining, for example, the degree of complementarity required between an RNAi-mediating agent and its target, i.e., whether mismatches are tolerated, the number of mismatches tolerated, the effect of the position of the mismatches, etc. Such rules are useful, in particular, in the design of improved RNAi-mediating agents which allow for more exact control of the efficacy of RNA silencing.06-12-2014
20140373188COMPOSITIONS FOR RNA INTERFERENCE AND METHODS OF USE THEREOF - The present invention provides compositions for RNA interference and methods of use thereof. In particular, the invention provides single-stranded small interfering RNAs. Functional and genomic and proteomic methods are featured. Therapeutic methods are also featured.12-18-2014

Patent applications by Guiliang Tang, Worcester, MA US

Howard Tang, Boston, MA US

Patent application numberDescriptionPublished
20120253389SURGICAL FILAMENT SNARE ASSEMBLIES - A surgical filament snare assembly including an anchor capable of being fixated in bone and having a filament engagement feature. A first filament has a noose with first and second noose limbs connected, preferably slidably, to the filament engagement feature. The first and second noose limbs emerge from the anchor as first and second free filament limbs that are capable of being passed through tissue to be repaired and then passable through the noose. The noose is capable of receiving the free filament limbs and strangulating them when tension is applied to at least one of the free filament limbs and the noose to enable incremental tensioning of the tissue after anchor fixation. Preferably, the snare assembly further includes a flexible sleeve joining at least some portion of the first and second free filament limbs to facilitate passing of the free filament limbs as a single unit.10-04-2012
20140188136METHODS FOR PASSING MULTIPLE SUTURES THROUGH TISSUE - Methods for passing multiple sutures through tissue are provided herein. In particular, the methods described herein allow multiple sutures to be passed through tissue without removing a suture passing instrument from a patient's body. In one embodiment, a method for passing a suture through tissue is provided that includes loading first and second suture limbs into a suture passing instrument, positioning the instrument within a patient's body, actuating the instrument to pass a portion of the first suture limb through the tissue, pulling the first suture limb through the tissue, pulling the second suture limb to reload the suture passing instrument without removing the instrument from the patient's body, actuating the instrument a second time to pass a portion of the second suture limb through the tissue, and pulling the second suture limb through the tissue.07-03-2014

Howard Tang, Raynham, MA US

Patent application numberDescriptionPublished
20120130423SURGICAL FILAMENT SNARE ASSEMBLIES - A surgical filament snare assembly including an anchor capable of being fixated in bone and having a filament engagement feature. A first filament has a noose on a first portion of at least a first limb and has a second portion connected to the filament engagement feature of the anchor. Preferably, at least one free filament limb, which in some embodiments is a length of the first filament and in other embodiments is a second filament, is capable of being passed through tissue to be repaired and has at least one end passable through the noose to enable incremental tensioning of the tissue after the anchor is fixated in bone. The noose strangulates the free filament limb when tension is applied to at least one of the free filament limb and the noose.05-24-2012
20120130424SURGICAL FILAMENT SNARE ASSEMBLIES - A surgical filament snare assembly including an anchor capable of being fixated in bone and having a filament engagement feature. A first filament has a noose with first and second noose limbs connected, preferably slidably connected, to the filament engagement feature of the anchor. The first and second noose limbs emerge from the anchor as first and second free filament limbs which are capable of being passed through tissue to be repaired and then passable through the noose. The noose, such as one or more half-hitches, is capable of receiving the free filament limbs and strangulating them when tension is applied to at least one of the free filament limbs and the noose to enable incremental tensioning of the tissue after the anchor is fixated. Preferably, the snare assembly further includes a flexible sleeve joining at least some portion of the first and second free filament limbs to facilitate passing of the free filament limbs at least through the tissue as a single unit.05-24-2012

Howard C. Tang, Boston, MA US

Patent application numberDescriptionPublished
20140277132Surgical Constructs with Collapsing Suture Loop and Methods for Securing Tissue - Surgical constructs and methods are provided for securing soft tissue to bone. One exemplary embodiment of a construct is formed from a suture filament and includes two terminal ends of filament and an intermediate portion disposed along at least a portion of a length extending between the terminal ends. The construct can have a first terminal end that is the first terminal end of the filament, and a second terminal end that includes a loop. The loop can be formed by disposing the second terminal end of the filament within a volume of a portion of the intermediate portion of the filament. In some disclosed methods, both terminal ends of the filament can be passed through tissue when performing soft tissue repairs. Various other embodiments of constructs and methods are provided, including constructs having two or more filaments associated with an anchor and methods of using such constructs.09-18-2014
20140343607Surgical Filament Snare Assemblies - A surgical filament snare assembly including an anchor capable of being fixated in bone and having a filament engagement feature. A first filament has a noose on a first portion of at least a first limb and has a second portion connected to the filament engagement feature of the anchor. Preferably, at least one free filament limb, which in some embodiments is a length of the first filament and in other embodiments is a second filament, is capable of being passed through tissue to be repaired and has at least one end passable through the noose to enable incremental tensioning of the tissue after the anchor is fixated in bone. The noose strangulates the free filament limb when tension is applied to at least one of the free filament limb and the noose.11-20-2014

Hui Tang, Acton, MA US

Patent application numberDescriptionPublished
20090208552CROSS-LINKED FATTY ACID-BASED BIOMATERIALS - Fatty acid-based, pre-cure-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.08-20-2009
20120213839HYDROPHOBIC CROSS-LINKED GELS FOR BIOABSORBABLE DRUG CARRIER COATINGS - Coatings for medical devices, methods of making the coatings, and methods of using them are described.08-23-2012
20150134073URETERAL STENTS WITH WAVEFORM INTERLAYERS AND INTERSTITCHING - Ureteral stents include a tubular body defining a lumen and have a distal kidney section, a proximal bladder section, and a ureter section between the distal and proximal sections. The tubular body has a first material layer and a stiffening member that extends through at least a portion of a length of the tubular body. The stiffening member has a stiffness characteristic that varies along its length. This enables different portions of the stent to have different stiffness characteristics that preferably are optimized for the location of those portions within the human body. The stiffening member may be at least a second material layer having a second stiffness that is different from a first stiffness of the first material layer, and/or at least one strand of material that is embedded within the first material layer.05-14-2015
20150209482CROSS-LINKED FATTY ACID-BASED BIOMATERIALS - Fatty acid-based, pre-cure-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.07-30-2015
20150224233CROSS-LINKED FATTY ACID-BASED BIOMATERIALS - Fatty acid-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.08-13-2015
20160089229URETERAL STENTS WITH WAVEFORM INTERLAYERS AND INTERSTITCHING - Ureteral stents include a tubular body defining a lumen and have a distal kidney section, a proximal bladder section, and a ureter section between the distal and proximal sections. The tubular body has a first material layer and a stiffening member that extends through at least a portion of a length of the tubular body. The stiffening member has a stiffness characteristic that varies along its length. This enables different portions of the stent to have different stiffness characteristics that preferably are optimized for the location of those portions within the human body. The stiffening member may be at least a second material layer having a second stiffness that is different from a first stiffness of the first material layer, and/or at least one strand of material that is embedded within the first material layer.03-31-2016

Patent applications by Hui Tang, Acton, MA US

Huy Khanh Tang, Westford, MA US

Patent application numberDescriptionPublished
20130239692Microelectronic Device Testing Apparatus and Method - A microelectronic device tester has a mounting member (for mounting a device), a drive shaft connected to the mounting member, and a vibration shaft mechanically in communication with the drive shaft. The drive shaft and vibration shaft are non-coaxial, and the drive shaft has a drive shaft proximal end and a drive shaft distal end. The drive shaft proximal end is connected to the mounting member, and the drive shaft distal end terminates proximal of the entire vibration shaft.09-19-2013

Hwan Tang, Lexington, MA US

Patent application numberDescriptionPublished
20090010168SYSTEM AND METHOD FOR MONITORING THE VOLUME OF CALLS CARRIED BY A VOICE OVER INTERNET PROTOCOL TELEPHONE SYSTEM - A method and a system for controlling the load of calls carried by a voice over Internet protocol telephone system attempts to reduce or eliminate the overloading of individual trunk groups and/or destination gateways. The system obtains information relating to a plurality of calls in the system, and analyzes the call information to determine if certain trunk groups or destination gateways are overloaded. If so, the system issues commands so that additional calls are diverted away from the overloaded trunk group or destination gateway.01-08-2009

Hwan Tang, Acton, MA US

Patent application numberDescriptionPublished
20090213846SYSTEM AND METHOD FOR VOICE OVER INTERNET PROTOCOL (VoIP) AND FACSIMILE OVER INTERNET PROTOCOL (FoIP) CALLING OVER THE INTERNET - A system and method for sending Long distance telephone calls over the Internet utilizes cost and quality of service data to optimize system performance and to minimize the cost of completing the calls. The system utilizes a network of gateways connected to the Internet. The gateways receive calls from various service providers and convert the analog calls into data packets which are then placed onto the Internet. Similarly, the gateways take data packets off the Internet, convert the data packets back into analog format, and provide the analog telephone calls to the same or another service provider. Then system periodically checks the quality of communications between each of the gateways, and uses this information, in combination with cost information, to determine how to route the calls over the Internet. Special addressing protocols can be used by a system embodying the invention to reduce or eliminate unnecessary signaling between gateways as call setup procedures are carried out. The system can also use information about calls that has been recorded in more than one location to determine how much to charge for completing a call.08-27-2009
20090238175SYSTEM AND METHOD FOR VOICE OVER INTERNET PROTOCOL (VoIP) AND FACSIMILE OVER INTERNET PROTOCOL (FoIP) CALLING OVER THE INTERNET - A system and method for sending long distance telephone calls over the Internet utilizes cost and quality of service data to optimize system performance and to minimize the cost of completing the calls. The system utilizes a network of gateways connected to the Internet. The gateways receive calls from various service providers and convert the analog calls into data packets which are then placed onto the Internet. Similarly, the gateways take data packets off the Internet, convert the data packets back into analog format, and provide the analog telephone calls to the same or another service provider. Then system periodically checks the quality of communications between each of the gateways, and uses this information, in combination with cost information, to determine how to route the calls over the Internet. Special addressing protocols can be used by a system embodying the invention to reduce or eliminate unnecessary signaling between gateways as call setup procedures are carried out. The system can also use information about calls that has been recorded in more than one location to determine how much to charge for completing a call.09-24-2009

Hwanjang Tang, Concord, MA US

Patent application numberDescriptionPublished
20110200033COMMON ROUTING - A method and corresponding apparatus are provided to route a call from a customer to a destination by: i) intercepting a call setup message sent from a customer switch intended to signal a switch to perform a call routing function or request a call routing function be performed, the call routing function determines a route for the switch to use to carry the call to the destination, the route so determined is a switch-determined route, ii) intercepting a call release message sent from the switch intended to signal the customer switch of network congestion, iii) in response to either the call setup message or the call release message being intercepted, querying a routing engine with the destination of the call for a specific route over which to carry the call to the destination, the specific route is queried from a set of routes that is different from an other set of routes from which the call routing function determines the switch-determined route, iv) modifying the call setup message to include the specific route, the call setup message so modified is a modified call setup message, v) responding to the call release message with a re-route call message that includes the specific route, and vi) directing the switch with either the modified call setup message or re-route call message to use the specific route to carry the call from the customer to the destination.08-18-2011
20130301638Common Routing - In an embodiment, call routing from a customer to a destination is provided by intercepting a call setup message sent from a customer switch intended to signal a switch to perform a call routing function. In response to the call setup message being intercepted, a routing engine is queried with the destination of the call for a specific route over which to carry the call to the destination. The call setup message is modified to include the specific route. The switch is directed with the modified call setup message to use the specific route to carry the call from the customer to the destination.11-14-2013

Hwan Jang Tang, Concord, MA US

Patent application numberDescriptionPublished
20140169286Method and System For Hub Breakout Roaming - According to at least one example embodiment, hub breakout roaming enables providing data access to a user network device, subscribed with a home network and roaming into a visited network, by a hub breakout system through the visited network. Upon receiving a request for data access from the visited network, the hub breakout system assigns an IP address to the user network device. The hub breakout system then routes data packets, associated with the data access requested by the user network device, to and from at least one corresponding data source, using the assigned IP address. The data source includes the Internet, a private network associated with home network, or any other service provider entity.06-19-2014
20140269510Method and Apparatus For Voice Over LTE - According to at least one example embodiment, a transit network is configured to handle signaling messages between service provider networks. Upon receiving, at the transit network, a session control message from a mobile network, a signaling type associated with the session control message is determined. The transit network then routes the session control message based on the signaling type determined. According to at least one aspect, the session control message is routed based on domain routing if the determined signaling type is roaming signaling. According to at least one other aspect, the session control message is routed based on called party number routing if the determined signaling type is non-roaming signaling.09-18-2014
20140269681Method And System For Call Routing - In an embodiment, a method and corresponding apparatus of managing call routing includes sending a first message by a session border controller (SBC) to a routing engine, the first message including event information indicative of an event related to a call, the event being associated with a second message received by the SBC; receiving a response message including call managing information related to the call, the call managing information being determined based on at least part of the event information, the call managing information to be returned to the routing engine in a subsequent message related to the call; and maintaining the call managing information received in the response message, the call managing information to be returned to the routing engine in a subsequent message related to the call.09-18-2014

Jihong Tang, Brighton, MA US

Patent application numberDescriptionPublished
20120060413INCREASING CARBON FLOW FOR POLYHYDROXYBUTYRATE PRODUCTION IN BIOMASS CROPS - Transgenic plants, transgenic plant material, and transgenic plant cells for the improved synthesis of polyhydroxyalkanoates, preferably poly(3-hydroxybutyrate) (also referred to as PHB), have been developed. In one embodiment, carbon flow is modulated to increase production of PHB. Preferred plants that can be genetically engineered to produce PHB include plants that produce a large amount of lignocellulosic biomass that can be converted into biofuels, such as switchgrass, 03-15-2012
20120174253GENERATION OF HIGH POLYHYDROXYBUTRATE PRODUCING OILSEEDS - Transgenic oilseed plants, plant material, plant cells, and genetic constructs for synthesis of polyhydroxyalkanoates (“PHA”) are provided. In a preferred embodiment, the transgenic oilseed plants synthesize (poly)3-hydroxybutyrate (“PHB”) in the seed. Genes utilized include phaA, phaB, phaC, all of which are known in the art. The genes can be introduced in the plant, plant tissue, or plant cell using conventional plant molecular biology techniques.07-05-2012
20120180162GENERATION OF HIGH POLYHYDROXYBUTRATE PRODUCING OILSEEDS - Transgenic plants, plant material, plant cells, and genetic constructs for synthesis of biopolymers, for example polyhydroxyalkanoates (“PHA”) are provided. In one embodiment, the transgenic plants synthesize polyhydroxybutyrate (“PHB”). In one embodiment the transgenic plant encodes siRNA for one or more of the genes encoding enzymes for producing PHA. In a more preferred embodiment, the siRNA expression is under the control of an inducible regulatory element. In another embodiment, the transgenic plant contains transgenes that encode expression enzymes that will degrade the polymer. In a preferred embodiment, the expression of these enzymes is under the control of a germination specific, inducible, or minimal promoter. In another embodiment, the transgenic plant contains transgenes encoding enzymes that increase carbon flow for polymer synthesis. In a preferred embodiment, these transgenes encode enzymes that increase carbon flow in the Calvin Cycle.07-12-2012

Josh C. Tang, Westford, MA US

Patent application numberDescriptionPublished
20120229277MONITORING AND ALERT SYSTEM FOR VENTILATED RACK SYSTEMS - The present invention is directed to monitoring/alert systems, devices, and methods useable with animal housing units. Embodiments include a primary component, such as a system controller device, for monitoring maintenance and operational events in a housing unit and a secondary component, such as a environmental monitoring device for analyzing environmental conditions. For example, the system controller device monitors unit functions (e.g., relating to power, pre-filter(s), filter(s), fan(s), air pressure, air temperature, electrical connections, etc.) and causes alert(s) to be sent (e.g., via email or text message) if there is a malfunction or abnormal operational data. The environmental monitoring device collects environmental data (e.g., time, temperature, humidity, light, sound, carbon dioxide levels, or ammonia levels) and causes alert(s) to be sent if an abnormal environmental condition is detected. The primary and secondary components may function in connection with one another, other devices, a network, or as stand-alone devices.09-13-2012

Kam Yan Tang, Cambridge, MA US

Patent application numberDescriptionPublished
20090097808Fluid waveguide and uses thereof - The invention relates to methods and apparatuses for guiding and emitting electromagnetic radiation from a fluid waveguide. Various methods for changing optical properties (e.g., refractive index, absorption, and fluorescence) and/or physical properties (e.g., magnetic susceptibility, electrical conductivity, and temperature) of either the waveguide core or the cladding, or both, are provided herein. In one embodiment, electromagnetic radiation is guided and/or emitted at multiple distinct wavelengths, including emission in the form of an essentially continuous band, in some cases covering at least 150 nanometers. In another embodiment, methods for splitting a waveguide core and/or the joining of at least two waveguide cores in a waveguide are provided. In yet another embodiment, the invention includes the use of thermal gradients to generate a waveguide and/or to change the properties of waveguides. Embodiments of the waveguides may be used for optical detection or spectroscopic analysis.04-16-2009
20140147627SLIPPERY SURFACES WITH HIGH PRESSURE STABILITY, OPTICAL TRANSPARENCY, AND SELF-HEALING CHARACTERISTICS - The present disclosure describes a strategy to create self-healing, slippery liquid-infused porous surfaces (SLIPS). Roughened (e.g., porous) surfaces can be utilized to lock in place a lubricating fluid, referred to herein as Liquid B to repel a wide range of materials, referred to herein as Object A (Solid A or Liquid A). SLIPS outperforms other conventional surfaces in its capability to repel various simple and complex liquids (water, hydrocarbons, crude oil and blood), maintain low-contact-angle hysteresis (<2.5°), quickly restore liquid-repellency after physical damage (within 0.1-1 s), resist ice, microorganisms and insects adhesion, and function at high pressures (up to at least 690 atm). Some exemplary application where SLIPS will be useful include energy-efficient fluid handling and transportation, optical sensing, medicine, and as self-cleaning, and anti-fouling materials operating in extreme environments.05-29-2014

Li Tang, Quincy, MA US

Patent application numberDescriptionPublished
20130274226SILICA NANOPARTICLE AGENT CONJUGATES - The invention provide a silica nanoparticle comprising a non-porous matrix of silicon-oxygen bonds, wherein the matrix comprises organic agents conjugated to silicon or oxygen atoms in the matrix, the organic agents are conjugated to the matrix through linker L groups, wherein the linker L comprises, for example, an ester, urea, thiourea, or thio ether group, and wherein the diameter of the nanoparticle is about 15 nm to about 200 nm. The invention also provides novel methods of making and using the silica nanoparticles described herein.10-17-2013
20150110740CARRIER-FREE BIOLOGICALLY-ACTIVE PROTEIN NANOSTRUCTURES - The present disclosure provides compositions and methods for efficient and effective protein delivery in vitro and in vivo. In some aspects, proteins are reversibly crosslinked to each other and/or modified with functional groups and protected from protease degradation by a polymer-based or silica-based nanoshell.04-23-2015

Lida Tang, Somerville, MA US

Patent application numberDescriptionPublished
20140053076Remote Use of Local Computing Components - A local computing device is connected to a remote computing device over a network. A user provides input to a local input component of the local computing device. The output of the local input component is converted into a form that is capable of being received as input by the remote computing device even if the local input component is not supported by the remote computing device. As one example, the local input component may be a bar code scanner which produces bar code output that is converted into text for input into a text field on the remote computing device, thereby enabling the remote computing device to receive input from a bar code scanner even if the remote computing device does not support the bar code scanner.02-20-2014

Ling Tang, Newton, MA US

Patent application numberDescriptionPublished
20160084984Systems and Methods For The Automatic Detection of Lithium Batteries in Cargo, Baggage, Parcels, and Other Containers - The present specification discloses methods for scanning objects for the presence of lithium batteries. Normalized transmission X-ray data is used to generate organic, effective Z, and attenuation-based images. These images are then segmented using a combination of thresholding and region growing techniques to identify regions of interest. The regions are classified as lithium batteries or other objects, based on characteristics such as area of the region, its organic intensity, Z03-24-2016

Melinda Tang, Cambridge, MA US

Patent application numberDescriptionPublished
20120297327INTERACTIVE CUSTOM REGIONS - One embodiment is directed to a computer program, embodied on a computer readable medium. The computer program is configured to control a processor to execute instructions. The instructions include receiving a selection of built-in interactive regions provided by a visualization component, aggregating the selected set of regions, and creating one or more custom regions from the aggregation of the selected set of regions.11-22-2012

Melinda Yian Tang, Cambridge, MA US

Patent application numberDescriptionPublished
20130187923LEGEND INDICATOR FOR SELECTING AN ACTIVE GRAPH SERIES - Various arrangements for identifying and selected a data value of a dataset presented on a graph are described. The graph may be presented, wherein the graph illustrates a plurality of datasets and a legend that identifies each of the plurality of datasets. A selection of the dataset may be received via the legend of the graph. An input of a point on the graph may be received. A value of a data point from the dataset that corresponds to the input of the point on the graph may be presented.07-25-2013

Pingping Tang, Quincy, MA US

Patent application numberDescriptionPublished
20110312903FLUORINATION OF ORGANIC COMPOUNDS - Methods for fluorinating organic compounds are described herein.12-22-2011
20120316341FLUORINATION OF ORGANIC COMPOUNDS - Methods for fluorinating organic compounds are described herein.12-13-2012

Qing Tang, Acton, MA US

Patent application numberDescriptionPublished
20100305155SUBSTITUTED PYRAZOLE INHIBITORS OF C-MET PROTEIN KINASE - The present invention relates to compounds of formula I, which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising compounds of formula I and methods of using the compositions in the treatment of proliferative disorders.12-02-2010
20110136789C-MET PROTEIN KINASE INHIBITORS - The present invention relates to compounds of formula I useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative disorders.06-09-2011
20110165120INHIBITORS OF SERINE PROTEASES - The present invention relates to compounds of formula I:07-07-2011
20110182856INHIBITORS OF SERINE PROTEASES - The present invention relates to compounds of formula (I):07-28-2011
20120165333C-MET PROTEIN KINASE INHIBITORS - The present invention relates to compounds of formula I useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative disorders.06-28-2012
20130190289COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS - A compound is represented by Structural Formula (I):07-25-2013
20140275024DNA-PK INHIBITORS - The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.09-18-2014
20140275059DNA-PK INHIBITORS - The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.09-18-2014

Patent applications by Qing Tang, Acton, MA US

Rickey Tang, Southwick, MA US

Patent application numberDescriptionPublished
20090171692Online Health Care Consumer Portal - An online health care consumer portal for accessing one or more health-related services by a health care consumer. The consumer portal includes an authentication module for identifying the health care consumer upon receiving an online identification token, and a database for maintaining health care information comprising a plurality of health records. The consumer portal also includes a rules engine module for applying a set of rules to the one or more health records corresponding to the consumer to determine an impairment profile of the health care consumer based on the health records corresponding to the health care consumer and an online user interface for providing access to the health-related services. The online user interface is configurable from a default configuration to a second configuration upon identification by the authentication module, the second configuration adapted to facilitate use of the online user interface according to the impairment profile.07-02-2009
20130066820SYSTEM AND METHOD FOR EVIDENCE-BASED DECISION BOOTSTRAPPING - The systems and methods relate to decision making processes. Data associated with a request for a decision is received. Risks associated with the request are identified. Decision queries associated with each of the identified risks are determined. Any non-standard attributes associated with each of the identified risks are identified. A confidence level threshold for each of the identified risks is determined. A decision recommendation, generated by a machine learning component, is received. The decision recommendation includes a response to each of the one or more decision queries, determined based on the exceptional attributes, if any, and a confidence level associated with the response. The confidence level is compared to the confidence level threshold. Based on the comparison, a decision path for responding to the request is determined. Decision path actions are determined based on the decision path.03-14-2013
20130197938SYSTEM AND METHOD FOR CREATING AND USING HEALTH DATA RECORD - Systems, methods and computer-readable media for creating and using a health data record. Data relating to a patient's health is received from one or more information sources. The data includes unstructured data and structured data elements. The unstructured data is parsed to identify data elements. At least some of the structured data elements and at least some of the data elements parsed from the unstructured data are normalized to create normalized data elements. A weight is assigned to the normalized data elements. The normalized data elements are mapped in accordance with an ontology. The mapped data is stored in a data repository in accordance with a data model.08-01-2013
20130226862SYSTEM AND METHOD FOR CREATING MACRO PROFILES - Creating a macro profile of an entity is disclosed. Attribute data associated with an entity is identified from (1) one or more public domain information sources and/or (2) one or more private domain information sources. One or more micro profiles for the entity are generated based on the identified data, each of the micro profiles describing the entity in a single dimension. Transactions associated with the entity and/or interactions between the entity and one or more other entities are monitored. A plurality of the generated micro profiles for the entity is selected. The selected micro profiles are associated to generate a macro profile for the entity, the macro profile describing the entity in multiple dimensions. The monitored transactions and/or monitored interactions are analyzed to identify any discrepancies in the macro profile. The macro profile is updated to account for the identified discrepancies.08-29-2013
20130250960System and Method for Routing Service Request Messages - A service request message is received. The service request message includes a payload portion and a context portion. Constituency specific attributes of the service request message and domain specific attributes of the service request message are identified from the payload portion. Context attributes, a service consumer identity, a service name and a service version are identified from the context portion. A service registry is queried using the service consumer identity, the service name and the service version to identify service metadata. An endpoint address to route the service request message is identified using the one or more constituency specific attributes, the one or more domain specific attributes and the service metadata.09-26-2013
20130311405System and Method for Situational Enablement of Context Aware Human Machine Interfaces - Data describing human-machine interfaces available to a user, facts relating to a circumstance of the user, a current human-machine interface being employed by the user, and an initial sentiment associated with the circumstance of the user is received. A target sentiment is computed based on the facts relating to a circumstance of the user. A navigation path to achieve the target sentiment based on the initial sentiment is determined. The next-best human-machine interface to be employed by the user is determined based on the navigation path, the one or more human-machine interfaces available to the user, and the current human-machine interface being employed by the user.11-21-2013
20130311967Method and System for Collapsing Functional Similarities and Consolidating Functionally Similar, Interacting Systems - Data identifying two or more functionally similar systems is received. Functional similarities across the two or more functionally similar systems are identified. The functional similarities are grouped into one or more categories. A proportion of each of the grouped functional similarities relative to each of the two or more functionally similar systems is measured. Based on the proportion of each of the grouped functional similarities, a non-redundant system comprising at least some functionality from each of the two or more functionally similar systems is identified.11-21-2013
20140149442Method and System for Encoding Integration of Coded Logical Information Systems - Data describing code sets of multiple systems is received. The received data includes a first code set associated with a first system and a second code set associated with a second system. Equivalencies between the first code set and the second code set are determined based on (1) logical definitions associated with the first code set and logical definitions associated with the second code set and (2) one or more outputs associated with the first system and one or more outputs associated with the second system. A coding scheme is identified to standardize the codes in the first code set and the codes in the second code set. Codes of the first code set are mapped to codes of the second code set using the coding scheme.05-29-2014

Patent applications by Rickey Tang, Southwick, MA US

Sai Chun Tang, Auburnbdale, MA US

Patent application numberDescriptionPublished
20150244178METHOD AND APPARATUS FOR WIRELESS MAGNETIC POWER TRANSMISSION - Systems for wirelessly transmitting power to an implanted medical device. The wireless transmission system including a first and second transmitting coil both the first and second coil having substantially equal diameters and at least one conductor winding. A gap between the first transmitting second transmitting coil extending along a common axis by a distance equal to the radius of the first transmitting coil. A plurality of capacitors connected in series along the at least one conductor of the transmitting coils to divide the transmitting coils into a plurality of coil segments. An input connection is electronically coupled to the transmitting coils to deliver an excitation voltage to the transmitting coils to produce a substantially uniform magnetic field between the first transmitting coil and the second transmitting coil.08-27-2015

Sai Chun Tang, Boston, MA US

Patent application numberDescriptionPublished
20150244178METHOD AND APPARATUS FOR WIRELESS MAGNETIC POWER TRANSMISSION - Systems for wirelessly transmitting power to an implanted medical device. The wireless transmission system including a first and second transmitting coil both the first and second coil having substantially equal diameters and at least one conductor winding. A gap between the first transmitting second transmitting coil extending along a common axis by a distance equal to the radius of the first transmitting coil. A plurality of capacitors connected in series along the at least one conductor of the transmitting coils to divide the transmitting coils into a plurality of coil segments. An input connection is electronically coupled to the transmitting coils to deliver an excitation voltage to the transmitting coils to produce a substantially uniform magnetic field between the first transmitting coil and the second transmitting coil.08-27-2015

Shannon Tang, Ware, MA US

Patent application numberDescriptionPublished
20150348520Violin Cushioning Device - An easily attachable and removable violin-cushioning device that contains an elongated cushion pad and two looped elastic ties for attachment to the lower body of a violin. The device attachment prevents any damage to the instrument. The cushion pad provides comfort to a player and reduces the strain of the violin against the player's neck during play. The device can be used by players of any size or shape. The device does not move during long periods or continued use. The device is small and lightweight to allow for easy storage and transport in the instrument's case.12-03-2015

Shuang Tang, Cambridge, MA US

Patent application numberDescriptionPublished
20140119981CONSTRUCTING BISMUTH ANTIMONY THIN FILMS WITH ANISOTROPIC SINGLE-DIRAC CONES05-01-2014

Shuyi Tang, Quincy, MA US

Patent application numberDescriptionPublished
201001304652-AMINOTHIAZOLE-4-CARBOXYLIC AMIDES AS PROTEIN KINASE INHIBITORS - The present invention relates to novel Anilinopiperazine Derivatives of formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.05-27-2010

Shuyi Tang, Belmont, MA US

Patent application numberDescriptionPublished
20100286135HETEROCYCLIC AMIDE COMPOUNDS AS PROTEIN KINASE INHIBITORS - The present invention relates to novel heterocyclic amide compounds of Formula I: as disclosed herein or a pharmaceutically acceptable salt, solvate, ester, prodrug or stereoisomer thereof. Also disclosed are compositions comprising said compounds, and methods for using said compounds for treating or preventing a proliferative disease, an anti-proliferative disorder, inflammation, arthritis, a neurological or neurodegenerative disease, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease or a fungal disease.11-11-2010
20100331313Thiazole Derivatives as Protein Kinase Inhibitors - The present invention relates to novel Thiazole Derivatives, compositions comprising the Thiazole Derivatives, and methods for using the Thiazole Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral infection, a fungal infection, or a disorder related to the activity of a protein kinase.12-30-2010
20120114739PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS - The present invention provides methods for inhibiting mTOR using pyrazolo[1,5-a]pyrimidine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with mTOR using such compounds.05-10-2012
20120322791PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS - The present invention provides Pyrazolopyrimidine Compounds of Formula (I):12-20-2012
20130150362NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS - The present invention relates to certain pyrazolo[1,5-a]pyrimidine compounds of Formula (I) as inhibitors of mammalian Target Of Rapamycin (mTOR) kinase, which is also known as FRAP, RAFT, RAPT or SEP. The compounds may be used in the treatment of cancer and other disorders where mTOR is deregulated. The present invention further provides pharmaceutical compositions comprising the pyrazolo[1,5-a]pyrimidine compounds.06-13-2013
20150258074NOVEL COMPOUNDS THAT ARE ERK INHIBITORS - Disclosed are the ERK inhibitors of formula (1.0), having a pyrazolopyridine base structure, and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (1.0).09-17-2015

Patent applications by Shuyi Tang, Belmont, MA US

Wei Tang, Dorchester, MA US

Patent application numberDescriptionPublished
20090142855Polynucleotides and Polypeptides of the IL-12 Family of Cytokines - The present invention relates to the primate family of cytokines. Provided herein are polynucleotides encoding such polypeptides, and reagents useful for producing the encoded polypeptides in a host source, and for identifying compounds which bind and modulate the activity of the encoded polypeptides. Also provided are reagents useful for the diagnosis or treatment of inflammatory and/or autoimmune related diseases in primates.06-04-2009

Wen Tang, Wilmington, MA US

Patent application numberDescriptionPublished
20110229887DETECTION OF NUCLEIC ACID AMPLIFICATION PRODUCTS IN THE PRESENCE OF AN INTERNAL CONTROL SEQUENCE ON AN IMMUNOCHROMATOGRAPHIC STRIP - Compositions and methods useful in nucleic acid assays are provided. The invention permits detection of test and control nucleic acids. Test nucleic acids can be immobilized at multiple locations, such that amplification of either a test nucleic acid or a control nucleic acid provides a captured nucleic acid in a control capture zone.09-22-2011

Xianchun Tang, West Roxbury, MA US

Patent application numberDescriptionPublished
20120064117TETRAVALENT INFLUENZA VACCINE AND USE THEREOF - Disclosed herein is the finding that baculovirus display of multiple influenza virus hemagglutinin (HA) proteins elicits broadly reactive immune responses against influenza. Thus provided herein are recombinant baculovirus vectors having a first, second, third and fourth nucleic acid sequence, each encoding an influenza hemagglutinin (HA) fusion protein. The first, second, third and fourth nucleic acid sequences each encode an influenza HA with a different amino acid sequence. Also provided are recombinant baculoviruses displaying a first, second, third and fourth influenza virus HA fusion protein in the baculovirus envelope, wherein each HA fusion protein comprises a different HA amino acid sequence. Tetravalent influenza virus vaccines comprising the recombinant baculoviruses disclosed herein are further provided. In addition, methods of immunizing a subject against influenza virus using the tetravalent influenza virus vaccines are provided. In particular examples of the compositions and methods disclosed herein, the HA polypeptides are from H5N1 influenza virus.03-15-2012

Xiaoqing Tang, Lexington, MA US

Patent application numberDescriptionPublished
20090221676GLUCOSE-TRANSPORT RELATED GENES, POLYPEPTIDES, AND METHODS OF USE THEREOF - Methods and compositions for modulating glucose transport are provided herein.09-03-2009

Xiaoren Tang, Winchester, MA US

Patent application numberDescriptionPublished
20090062190Transcriptional Regulation of Cytokines by LITAF and STAT (6)(B) - The present invention relates to novel proteins (LITAF and STAT6(B)) and the nucleotide sequences encoding the same. The present invention also relates to the use of the novel peptides and nucleotide sequences of the present invention, or functional fragments thereof, for the regulation of cytokine expression. The present invention also relates to the use of the novel proteins and nucleotides sequences of the present invention for the regulation of inflammatory responses in mammals including the regulation of angiogenesis and tubulogenesis. Also in this regard, the present invention relates to the generation of null mutant animals deficient in the expression of one or both of the proteins of the present invention.03-05-2009
20090215049NOVEL LITAF BINDING SITE PEPTIDES AND METHODS OF USING THE SAME - The invention provides molecules containing nucleic acid sequences for fragments of LPS-induced TNF-α factor (LITAF) and vectors containing these sequences. Also provided are molecules that contain the peptide sequence SQTWREPGAAGSPFHL, or homologs thereof. Such molecules may be useful in the treatment of diseases that relate to the expression of TNF-α, where treatment involves the modulation of this expression. The invention also provides methods for identifying compounds that inhibit or enhance the transcription of TNF-α.08-27-2009
20110288035PIMAP39 MODULATES INFLAMMATORY RESPONSE - The present invention relates to a novel peptide sequence named PIMAP39 (herein referred to as SEQ ID NO.: 1) and methods of use of the novel sequence and functional variants thereof. The present invention also relates to methods for reducing and/or modulating inflammatory responses by administration of the peptide of the present invention. Furthermore, the present invention relates to the modulation of the expression of cytokines effected as part of an inflammatory response by administration of the peptide of the present invention.11-24-2011
20130130993PIMAP39 MODULATES INFLAMMATORY RESPONSE - The present invention relates to a novel peptide sequence named PIMAP39 (herein referred to as SEQ ID NO.: 1) and methods of use of the novel sequence and functional variants thereof. The present invention also relates to methods for reducing and/or modulating inflammatory responses by administration of the peptide of the present invention. Furthermore, the present invention relates to the modulation of the expression of cytokines effected as part of an inflammatory response by administration of the peptide of the present invention.05-23-2013

Patent applications by Xiaoren Tang, Winchester, MA US

Ying Tang, Cambridge, MA US

Patent application numberDescriptionPublished
20110253055ANIMAL LITTERS - The invention provides animal litters and methods of making and using such litters. The animal litters comprise (a) a plurality of absorbent particles comprising (i) a non-swelling particle and (ii) a clumping material coated on the non-swelling particle and (b) a plurality of one or more filler particles that are not associated with the absorbent particles. The filler particles provide additional functionality to the litters, e.g., controlling odor, absorbing moisture, releasing fragrance, controlling microorganisms, controlling dust, reducing density, reducing weight, and combinations thereof. The litters are made by producing the absorbent particles using conventional means and combining the absorbent particles with one or more filler particles that impart the desired characteristic to the litters.10-20-2011

Y. Tom Tang, Beverly, MA US

Patent application numberDescriptionPublished
20080200388Stem cell factor-like proteins and uses thereof - The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor SCFA2, SCFA4 or SCFA4v polynucleotides and polypeptides. The invention further relates to the therapeutic use of SCFA2, SCFA4 or SCFA4v to prevent or treat conditions or disorders associated with the degeneration of the epithelial mucosa.08-21-2008
20100278800Stem cell factor-like proteins and uses thereof - The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor SCFA2, SCFA4 or SCFA4v polynucleotides and polypeptides. The invention further relates to the therapeutic use of SCFA2, SCFA4 or SCFA4v to prevent or treat conditions or disorders associated with the degeneration of the epithelial mucosa.11-04-2010

Patent applications by Y. Tom Tang, Beverly, MA US

Yuehua Tang, Boylston, MA US

Patent application numberDescriptionPublished
20090029147AEROGEL-FOAM COMPOSITES - The invention provides reinforced aerogel monoliths as well as reinforced composites thereof for a variety of uses. Compositions and methods of preparing the monoliths and composites are also provided. Application of these materials in transparent assemblies is also discuss.01-29-2009

Yun Tang, Cambridge, MA US

Patent application numberDescriptionPublished
20120267605Methods for the Production of Nanoscale Heterostructures - The present invention is directed to a novel synthetic method for producing nanoscale heterostructures, and particularly nanoscale heterostructure particles, rods and sheets, that comprise a metal core and a monocrystalline semiconductor shell with substantial lattice mismatches between them. More specifically, the invention concerns the use of controlled soft acid-base coordination reactions between molecular complexes and colloidal nanostructures to drive the nanoscale monocrystalline growth of the semiconductor shell with a lattice structure incommensurate with that of the core. The invention also relates to more complex hybrid core-shell structures that exhibit azimuthal and radial nano-tailoring of structures. The invention is additionally directed to the use of such compositions in semiconductor devices.10-25-2012

Yun-Chi Tang, Cambridge, MA US

Patent application numberDescriptionPublished
20100323979METHODS AND COMPOSITIONS FOR INHIBITING PROLIFERATION OF ANEUPLOID CELLS - The present invention relates, in part, to the use of AMP kinase agonists to reduce or inhibit the proliferation of aneuploid cells. The invention is also directed to the use AMP kinase agonists to reduce or inhibit the proliferation of solid tumors characterized by aneuploidy in an individual.12-23-2010

Yuting Tang, Lexington, MA US

Patent application numberDescriptionPublished
20140377281LECTIN-LIKE OXIDIZED LDL RECEPTOR 1 ANTIBODIES AND METHODS OF USE - The present invention relates to monoclonal antibodies binding to human lectin-like oxidized LDL (low density lipoprotein) receptor 1 (hereinafter, sometimes referred to as “LOX-1”), and pharmaceutical compositions and methods of treatment comprising the same.12-25-2014

Yuying Tang, Hadley, MA US

Patent application numberDescriptionPublished
20090192525TAPE-BASED SKIN TREATMENT - A SAFE AND QUICK ALTERNATIVE TO SKIN RENEWAL - A skin renewal sheet for exfoliating skin includes a flexible backing layer, a skin-friendly pressure-sensitive adhesive layer disposed on one side of the backing layer and a release layer disposed on the skin friendly pressure sensitive adhesive layer wherein the pressure sensitive adhesive layer has a 180° peel force of from about 0.5 lbs/in. to about 5.0 lbs/in.07-30-2009
20150155538ELECTRICAL INSULATION LAYER AND BATTERY DEVICE - An electrical insulation layer including microparticles and having a mesoporous structure; and a battery device including a cathode, an anode, an electrical insulation layer including microparticles and having a mesoporous structure, the electrical insulation layer being arranged between the anode and the cathode, and an ion conductive composition.06-04-2015
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