Patent application number | Description | Published |
20080280846 | 2', 3'-DIDEOXYNUCLEOSIDE ANALOGUES FOR THE TREATMENT OR PREVENTION OF FLAVIVIRIDAE INFECTIONS - A method for the treatment or prevention of Flaviviridae infections, in particular, hepatitis C virus infection, in a host, and in particular, a human, is provided that includes administering an effective amount of a β-L- or β-D-2′,3′-dideoxynucleoside or a pharmaceutically acceptable salt or prodrug thereof, optionally in a pharmaceutically acceptable diluent or excipient. | 11-13-2008 |
20120077738 | COMPOSITIONS AND METHODS FOR PREDICTING HCV SUSCEPTIBILITY TO ANTIVIRAL AGENTS - Methods for determining the susceptibility of a hepatitis C virus (HCV) in a patient to anti-viral agents, particularly cyclophilin inhibitors such as cyclosporine A, are disclosed. The methods include determining the amino acid sequence within a region of the HCV NS5A protein and comparing the viral amino acid sequence to that of a reference strain, wherein the existence of at least one variant/mutation in the viral genome is indicative that the virus is more or less susceptible to anti-viral agents. Also disclosed are isolated polynucleotide molecules, replicons, and kits that can be used to assay the susceptibility of hepatitis HCV in a patient to anti-viral agents. | 03-29-2012 |
Patent application number | Description | Published |
20100284966 | Methods and Compositions for Managing Resistance of Hepatitis C Virus to Immunosuppressant - Method for determining susceptibility of a hepatitis C virus (HCV) in a patient, especially one who received a liver transplant, to cyclosporine A (CsA), comprising determining the nucleic acid sequence of HCV, and comparing the viral nucleic acid sequence to that of a wild-type, CsA susceptible strain, wherein the existence of at least one mutation in the viral genome is indicative that the virus is resistant to CsA. Also provided are isolated polynucleotide molecules comprising one or more mutations, an array of such molecules, a kit comprising at least one isolated polynucleotide. A method of monitoring the development CsA resistance in a HCV patient, and managing treatment regimens accordingly is further provided. The present invention further provides CsA resistant HCV replicons and method of using them for anti-viral drug screening. | 11-11-2010 |
20140271726 | COMPOSITIONS AND METHODS FOR PREDICTING HCV SUSCEPTIBILITY TO ANTIVIRAL AGENTS - Provided herein are methods for determining the susceptibility of a hepatitis C virus (HCV) in a patient to anti-viral agents, particularly cyclophilin inhibitors such as cyclosporine A. More particularly, provided herein are methods for determining the amino acid sequence within a region of the HCV NS5A protein and comparing the viral amino acid sequence to that of a reference strain, wherein the existence of at least one variation in the viral genome is indicative that the virus is more or less susceptible to anti-viral agents relative to the reference strain. Also provided are isolated polynucleotide molecules, replicons, and kits that can be used to assay the susceptibility of a particular HCV to an anti-viral agent. | 09-18-2014 |
Patent application number | Description | Published |
20110210013 | SELECTIVE GAS SENSOR DEVICE AND ASSOCIATED METHOD - A detection system is presented. The detection system includes a sensing component and a data analyzer. The sensing component includes a first sensor and a second sensor in fluid communication with the first sensor. The first sensor is disposed to allow operation at a predetermined temperature T | 09-01-2011 |
20110217616 | BOND LAYER FOR A SOLID OXIDE FUEL CELL, AND RELATED PROCESSES AND DEVICES - An electrically-conductive layer of material having a composition comprising lanthanum and strontium is described. The material is characterized by a microstructure having bimodal porosity. Another concept in this disclosure relates to a solid oxide fuel cell attached to at least one cathode interconnect by a cathode bond layer. The bond layer includes a microstructure having bimodal porosity. A fuel cell stack which incorporates at least one of the cathode bond layers is also described herein, along with related processes for forming the cathode bond layer. | 09-08-2011 |
20110221456 | SENSOR SYSTEM AND METHODS FOR ENVIRONMENTAL SENSING - A sensor system, and an associated method for detecting harsh environmental conditions, is provided. The sensor system includes at least one sensor having an electrical sensing element. The electrical sensing element is based on certain classes of composite materials: (a) silicon carbide (SiC); (Mo,W) | 09-15-2011 |
20150147621 | METHODS FOR THE FORMATION OF BETA ALUMINA ELECTROLYTES, AND RELATED STRUCTURES AND DEVICES - A method for preparing an electrolyte separator for an electrochemical device is described. The method includes the step of applying a beta″-alumina coating composition, or a precursor thereof, to a porous substrate, by an atmospheric, thermal spray technique. An electrochemical device is also described. Some of these devices include an anode, a cathode, and an electrolyte separator disposed between the anode and the cathode. The separator includes a thermally-sprayed layer of beta″-alumina, disposed on a porous substrate. The electrochemical device can be used as an energy storage system, or for other types of end uses. | 05-28-2015 |
Patent application number | Description | Published |
20080299436 | COMPOSITE CERAMIC ELECTROLYTE STRUCTURE AND METHOD OF FORMING; AND RELATED ARTICLES - A composite ceramic electrolyte is provided. The composite ceramic electrolyte has a microstructure, which comprises a first ceramic composition comprising a plurality of nano-dimensional microcracks, and a second ceramic composition substantially embedded within at least a portion of the plurality of nano-dimensional microcracks. The first and the second compositions are different. A solid oxide fuel cell comprising a composite ceramic electrolyte having such a microstructure is provided. A method of making a composite ceramic electrolyte is also described. The method includes the steps of: providing a first ceramic composition comprising a plurality of nano-dimensional microcracks; and closing a number of the nano-dimensional microcracks with a second ceramic composition, wherein the first and the second compositions are different, so as to form a composite ceramic electrolyte having a microstructure which comprises a first ceramic composition comprising a plurality of nano-dimensional microcracks and a second ceramic composition substantially embedded within at least a portion of the plurality of nano-dimensional microcracks. | 12-04-2008 |
20090075146 | METHOD OF PROCESSING A CERAMIC LAYER AND RELATED ARTICLES - A method of processing a ceramic layer is provided. The method comprises the steps of providing a ceramic layer comprising a plurality of microcracks; infiltrating at least some of the plurality of microcracks with a liquid precursor comprising at least one oxidizable metal ion; and exposing the ceramic layer to a base having a pH value of at least about 9, so as to chemically convert the oxidizable metal ion into an oxide, thereby decreasing the porosity of the ceramic layer. A solid oxide fuel cell is provided. The solid oxide fuel cell comprises an anode; a cathode; and a ceramic electrolyte disposed between the anode and the cathode. The ceramic electrolyte is processed by the method comprising the steps of providing a ceramic electrolyte comprising a plurality of microcracks; infiltrating at least some of the plurality of microcracks with a liquid precursor comprising at least one oxidizable metal ion; and exposing the ceramic electrolyte to a base having a pH value of at least about 9, so as to chemically convert the oxidizable metal ion into an oxide, thereby decreasing the porosity of the ceramic electrolyte. | 03-19-2009 |
20120178015 | METHOD OF PROCESSING A CERAMIC ELECTROLYTE, AND RELATED ARTICLES - A method of processing a ceramic electrolyte suitable for use in a fuel cell is provided. The method comprises situating a ceramic electrolyte layer over an anode layer; and subjecting the ceramic electrolyte layer to a stress prior to operation of the fuel cell, by: exposing the top surface of the electrolyte layer to an oxidizing atmosphere and the bottom surface of the electrolyte layer to a reducing atmosphere; and heating the electrolyte layer. The stress causes a substantial increase in the number of microcracks, or in the average size of the microcracks, or in both the number of the microcracks and their average size. A solid oxide fuel cell comprising a ceramic electrolyte layer processed by the disclosed method is also provided. | 07-12-2012 |