| Patent application number | Description | Published |
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| 20080269160 | INDUCED ACTIVATION IN DENDRITIC CELLS - The present invention is directed to a composition and method which to treat diseases and to enhance a regulated immune response. More particularly, the present invention is drawn to compositions that are based on dendritic cells modified to express an inducible form of a co-stimulatory polypeptide. | 10-30-2008 |
| 20100196336 | MODIFIED DENDRITIC CELLS HAVING ENHANCED SURVIVAL AND IMMUNOGENICITY AND RELATED COMPOSITIONS AND METHODS - Modified antigen presenting cells provided herein have improved lifespan and immunogenicity compared to unmodified antigen presenting cells, and are useful for immunotherapy. The modified antigen presenting cells express an altered protein kinase, referred to herein as “Akt.” The altered Akt associates with the cell membrane with greater frequency than unaltered Akt, and is referred to herein as “membrane-targeted Akt.” | 08-05-2010 |
| 20100203067 | METHODS AND COMPOSITIONS FOR GENERATING AN IMMUNE RESPONSE BY INDUCING CD40 AND PATTERN RECOGNITION RECEPTOR ADAPTERS - Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing an inducible pattern recognition receptor adapter, or adapter fragment, and CD40 activity. Also provided are nucleic acid compositions comprising sequences coding for chimeric proteins that include an inducible CD40 peptide and an inducible pattern recognition receptor adapter or adapter fragment. | 08-12-2010 |
| 20100323420 | REGULATED APOPTOSIS - We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins and disclose methods and materials for using that procedure to regulatably initiate cell-specific apoptosis (programmed cell death) in genetically engineered cells. | 12-23-2010 |
| 20110033383 | METHODS AND COMPOSITIONS FOR GENERATING AN IMMUNE RESPONSE BY INDUCING CD40 AND PATTERN RECOGNITION RECEPTORS AND ADAPTORS THEREOF - Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing pattern recognition receptor activity, and CD40 activity. Also provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing CD40 activity without prostaglandin E2. Also provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing an inducible chimeric molecule comprising a region of a pattern recognition receptor or an adaptor thereof. | 02-10-2011 |
| 20130130386 | MODIFIED DENDRITIC CELLS HAVING ENHANCED SURVIVAL AND IMMUNOGENICITY AND RELATED COMPOSITIONS AND METHODS - Modified antigen presenting cells provided herein have improved lifespan and immunogenicity compared to unmodified antigen presenting cells, and are useful for immunotherapy. The modified antigen presenting cells express an altered protein kinase, referred to herein as “Akt.” The altered Akt associates with the cell membrane with greater frequency than unaltered Akt, and is referred to herein as “membrane-targeted Akt.” | 05-23-2013 |
| 20130183333 | INDUCED ACTIVATION IN DENDRITIC CELLS - The present invention is directed to a composition and method which to treat diseases and to enhance a regulated immune response. More particularly, the present invention is drawn to compositions that are based on dendritic cells modified to express an inducible form of a co-stimulatory polypeptide. | 07-18-2013 |
| 20140023647 | METHOD FOR TREATING SOLID TUMORS - Provided herein are methods for treating a solid tumor in a subject in need thereof by activating an immune response against a tumor antigen. Also provided are methods for treating a solid tumor in a subject in need thereof by activating antigen-presenting cells and eliciting an immune response against a tumor antigen. Also provided herein are optimized therapeutic treatments of solid tumors, which comprise determining the presence, absence or amount of a biomarker after the therapy has been administered, and determining whether a subsequent dose of the therapy should be maintained, increased, or decreased based on the biomarker assessment. | 01-23-2014 |
| 20140087468 | METHODS AND COMPOSITIONS FOR GENERATING AN IMMUNE RESPONSE BY INDUCING CD40 AND PATTERN RECOGNITION RECEPTOR ADAPTERS - Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing an inducible pattern recognition receptor adapter, or adapter fragment, and CD40 activity. Also provided are nucleic acid compositions comprising sequences coding for chimeric proteins that include an inducible CD40 peptide and an inducible pattern recognition receptor adapter or adapter fragment. | 03-27-2014 |
| 20140255360 | MODIFIED CASPASE POLYPEPTIDES AND USES THEREOF - The technology relates in part to compositions comprising modified Caspase-9 polypeptides, compositions comprising nucleic acids coding for modified Caspase-9 polypeptides, chimeric modified Caspase-9 polypeptides, and methods of use thereof, including methods for cell therapy. Methods for cell therapy include modifying transfused cells to express an inducible modified Caspase-9 protein, with reduced basal activity in the absence of the inducer. | 09-11-2014 |
| 20140286987 | METHODS FOR CONTROLLING T CELL PROLIFERATION - The technology relates generally to the field of immunology and relates in part to compositions and methods for controlling the proliferation of T cells, for example, therapeutic T cells. The methods further relate to compositions and methods for inducing an immune response in a subject. | 09-25-2014 |
| 20140287490 | METHODS AND COMPOSITIONS FOR GENERATING AN IMMUNE RESPONSE BY INDUCING CD40 AND PATTERN RECOGNITION RECEPTORS AND ADAPTORS THEREOF - Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing pattern recognition receptor activity, and CD40 activity. Also provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing CD40 activity without prostaglandin E2. Also provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing an inducible chimeric molecule comprising a region of a pattern recognition receptor or an adaptor thereof. | 09-25-2014 |
| 20150111294 | METHODS AND COMPOSITIONS FOR GENERATING AN IMMUNE RESPONSE BY INDUCING CD40 AND PATTERN RECOGNITION RECEPTOR ADAPTERS - Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing an inducible pattern recognition receptor adapter, or adapter fragment, and CD40 activity. Also provided are nucleic acid compositions comprising sequences coding for chimeric proteins that include an inducible CD40 peptide and an inducible pattern recognition receptor adapter or adapter fragment. | 04-23-2015 |
| 20150306140 | INDUCED ACTIVATION IN DENDRITIC CELLS - The present invention is directed to a composition and method which to treat diseases and to enhance a regulated immune response. More particularly, the present invention is drawn to compositions that are based on dendritic cells modified to express an inducible form of a co-stimulatory polypeptide. | 10-29-2015 |
| 20150328292 | CASPASE POLYPEPTIDES HAVING MODIFIED ACTIVITY AND USES THEREOF - The technology relates in part to compositions comprising modified caspase-9 polypeptides, compositions comprising nucleic acids coding for modified caspase-9 polypeptides, chimeric modified caspase-9 polypeptides, and methods of use thereof, including methods for cell therapy. Methods for cell therapy include modifying transfused cells to express an inducible modified caspase-9 protein, with reduced basal activity in the absence of the inducer. | 11-19-2015 |
| 20160046700 | METHODS FOR ACTIVATING T CELLS USING AN INDUCIBLE CHIMERIC POLYPEPTIDE - The technology relates generally to the field of immunology and relates in part to methods for activating cells, including for example T cells and T cells that express chimeric antigen receptors, using an inducible chimeric polypeptide including CD40, MyD88, or CD40 and MyD88 polypeptides. The technology further relates in part to therapeutic methods for inducing an immune response and treating tumors in a patient. | 02-18-2016 |
| 20160058857 | COSTIMULATION OF CHIMERIC ANTIGEN RECEPTORS BY MYD88 AND CD40 POLYPEPTIDES - The technology relates generally to the field of immunology and relates in part to methods for activating T cells and other cells resulting in an immune response against a target antigen. The technology also relates to costimulation of therapeutic cells that express chimeric antigen receptors that recognize target antigens using chimeric MyD88- and CD40-derived polypeptides. The technology further relates in part to therapeutic cells that express chimeric antigen receptors, wherein the chimeric antigen receptors have an endodomain that includes MyD88- and CD40-derived polypeptides, and methods for treating patients using the modified therapeutic cells. | 03-03-2016 |
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| 20090060888 | Regulated transcription of targeted genes and other biological events - Dimerization and oligomerization of proteins are general biological control mechanisms that contribute to the activation of cell membrane receptors, transcription factors, vesicle fusion proteins, and other classes of intra- and extracellular proteins. We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins. In principle, any two target proteins can be induced to associate by treating the cells or organisms that harbor them with cell permeable, synthetic ligands. To illustrate the practice of this invention, we have induced: (1) the intracellular aggregation of the cytoplasmic tail of the ζ chain of the T cell receptor (TCR)-CD3 complex thereby leading to signaling and transcription of a reporter gene, (2) the homodimerization of the cytoplasmic tail of the Fas receptor thereby leading to cell-specific apoptosis (programmed cell death) and (3) the heterodimerization of a DNA-binding domain (Gal4) and a transcription-activation domain (VP16) thereby leading to direct transcription of a reporter gene. | 03-05-2009 |
| 20110003385 | REGULATED TRANSCRIPTION OF TARGETED GENES AND OTHER BIOLOGICAL EVENTS - Dimerization and oligomerization of proteins are general biological control mechanisms that contribute to the activation of cell membrane receptors, transcription factors, vesicle fusion proteins, and other classes of intra- and extracellular proteins. We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins. In principle, any two target proteins can be induced to associate by treating the cells or organisms that harbor them with cell permeable, synthetic ligands. To illustrate the practice of this invention, we have induced: (1) the intracellular aggregation of the cytoplasmic tail of the ζ chain of the T cell receptor (TCR)-CD3 complex thereby leading to signaling and transcription of a reporter gene, (2) the homodimerization of the cytoplasmic tail of the Fas receptor thereby leading to cell-specific apoptosis (programmed cell death) and (3) the heterodimerization of a DNA-binding domain (Gal4) and a transcription-activation domain (VP16) thereby leading to direct transcription of a reporter gene. | 01-06-2011 |
| 20110287038 | METHOD FOR TREATING SOLID TUMORS - Provided herein are methods for treating a solid tumor in a subject in need thereof by activating an immune response against a tumor antigen. Also provided are methods for treating a solid tumor in a subject in need thereof by activating antigen-presenting cells and eliciting an immune response against a tumor antigen. Also provided herein are optimized therapeutic treatments of solid tumors, which comprise determining the presence, absence or amount of a biomarker after the therapy has been administered, and determining whether a subsequent dose of the therapy should be maintained, increased, or decreased based on the biomarker assessment. | 11-24-2011 |
| 20130323214 | CHIMERIC CD27 RECEPTORS FOR REDIRECTING T CELLS TO CD70-POSITIVE MALIGNANCIES - The present invention concerns methods and compositions related to T cells redirected against CD70 for the immunotherapy of CD70-positive malignancies. In aspects of the invention, T cells that are CD70-specific are employed. In particular aspects, there are T cells expressing a novel molecule that comprises the full-length CD70 receptor (CD27) fused to the zeta signaling domain of the T-cell receptor complex. Such T cells recognized CD70-positive tumor cells and have cytolytic activity against CD70-positive cancer cells. | 12-05-2013 |
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| 20130087329 | METHOD OF TRACING FLOW OF HYDROCARBON FROM A SUBTERRANEAN RESERVOIR - A method of tracing flow of hydrocarbon from a subterranean reservoir including forming a dispersion, injecting a hydraulic fracturing fluid containing the dispersion down a well penetrating a hydrocarbon reservoir, thereafter collecting a sample of hydrocarbon fluid flowing from the reservoir, and analysing the sample to determine whether the tracer compound is present in the sample. The dispersion includes a discontinuous condensed phase having a hydrocarbon-soluble tracer compound and a continuous phase which includes an aqueous liquid. | 04-11-2013 |
| 20130277048 | METHOD OF TRACING FLOW OF HYDROCARBON FROM A SUBTERRANEAN RESERVOIR - A method of tracing flow of hydrocarbon from a subterranean reservoir including forming a dispersion, injecting a hydraulic fracturing fluid containing the dispersion down a well penetrating a hydrocarbon reservoir, thereafter collecting a sample of hydrocarbon fluid flowing from the reservoir, and analysing the sample to determine whether the tracer compound is present in the sample. The dispersion includes a discontinuous condensed phase having a hydrocarbon-soluble tracer compound and a continuous phase which includes an aqueous liquid. | 10-24-2013 |
| 20140174730 | METHOD OF TRACING FLOW OF HYDROCARBON FROM A SUBTERRANEAN RESERVOIR - A method of tracing flow of hydrocarbon from a subterranean reservoir including forming a dispersion, injecting a hydraulic fracturing fluid containing the dispersion down a well penetrating a hydrocarbon reservoir, thereafter collecting a sample of hydrocarbon fluid flowing from the reservoir, and analysing the sample to determine whether the tracer compound is present in the sample. The dispersion includes a discontinuous condensed phase having a hydrocarbon-soluble tracer compound and a continuous phase which includes an aqueous liquid. | 06-26-2014 |
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| 20090071659 | Anchoring System for Use in a Wellbore - A technique enables anchoring of a tool in a wellbore. The technique utilizes one or more arms pivotably mounted to a structure for movement between a radially inward position and radially outward position that anchors the tool to a surrounding wall. A wedge component is positioned to selectively engage the arms. When relative axial movement is caused between the wedge component and the arms, the arms are pivoted to a desired radial position. | 03-19-2009 |
| 20090071660 | Low Stress Traction System - A technique enables anchoring of a tool in a wellbore. The technique provides traction against a well component without creating high stress concentrations that weaken the well component. An anchoring device comprises anchoring members that are selectively movable to an expanded configuration for anchoring the tool. The anchoring members have traction surfaces able to selectively engage a smooth anchoring surface of the well component at any desired location along the well component. Each traction surface is formed to facilitate traction while minimizing stress concentration. | 03-19-2009 |
| 20130025884 | LOW STRESS TRACTION SYSTEM - A technique enables anchoring of a tool in a wellbore. The technique provides traction against a well component without creating high stress concentrations that weaken the well component. An anchoring device comprises anchoring members that are selectively movable to an expanded configuration for anchoring the tool. The anchoring members have traction surfaces able to selectively engage a smooth anchoring surface of the well component at any desired location along the well component. Each traction surface is formed to facilitate traction while minimizing stress concentration. | 01-31-2013 |
| 20140174761 | Downhole Shifting Tool - A shifting tool for use in shifting axial position of a shiftable element in a well. The tool comprises a linkage mechanism configured to translate an independent axial force into a dedicated radial force applied to expansive elements thereof. Thus, the elements may radially expand into engagement with the shiftable element free of any substantial axial force imparted thereon. As such, a more discretely controllable shifting actuation may be attained, for example, as directed from an oilfield surface. Indeed, real-time intelligent feedback may also be made available through use of such elements in conjunction with the noted linkage mechanism. | 06-26-2014 |
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| 20120180576 | Evacuating a Sample Chamber - In one general aspect, a sample is transferred into a mass spectrometer by capturing a sample on a collector, inserting the collector into a sample chamber coupled to the mass spectrometer and a vacuum pump, evacuating the sample chamber using the vacuum pump to reduce an internal pressure of the sample chamber to a level less than atmospheric pressure, heating the collector to release the sample from the collector, and introducing the sample into the mass spectrometer from the evacuated sample chamber. | 07-19-2012 |
| 20120223226 | Introducing An Analyte Into A Chemical Analyzer - A chemical pre-concentrator includes a conduit defining a flow path between two ends and having a heating element disposed within the conduit, such that the heating element has at least one sorbent material deposited directly on at least a portion of a conductive surface of the heating element. Some such heating elements are in the form of electrically conductive strips defining both a plurality of apertures through the strip and a series of undulations spaced along the flow path. | 09-06-2012 |
| 20120270334 | PRECONCENTRATING A SAMPLE - A chemical analysis system is disclosed wherein, in evacuating a preconcentrator housing ( | 10-25-2012 |
| 20140190245 | REDUCED PRESSURE LIQUID SAMPLING - Processing a liquid sample ( | 07-10-2014 |
| 20140250977 | CHEMICAL ANALYSIS INSTRUMENT WITH MULTI-PURPOSE PUMP - A mass spectrometer for analyzing a sample may include an analysis chamber for analyzing the sample and a first vacuum pump operably connected to the analysis chamber, wherein the first vacuum pump operates to create a first vacuum state. The mass spectrometer may also include a sample-preparation chamber operably connected to the analysis chamber and a second vacuum pump that operates to create a second vacuum state, wherein the first vacuum state is a lower pressure than the second vacuum state. The second vacuum pump may be operably connected to the first vacuum pump in a first configuration, and the second vacuum pump may be operably connected to the sample-preparation chamber in a second configuration. | 09-11-2014 |
| 20140252215 | SYSTEMS AND METHODS FOR CALIBRATING MASS SPECTROMETERS - Systems and methods are disclosed for calibrating mass spectrometers. In accordance with one implementation, a system comprises a calibrant chamber within a housing of a mass spectrometer. The system also comprises a permeation tube enclosed within the calibrant chamber, wherein the tube contains a calibrant chemical that continuously outgasses the calibrant chemical. The outgassed calibrant chemical may be introduced to the mass spectrometer for analysis. The system may also comprise a heating block to control the temperature of the calibrant chemical. The system may further comprise a valve that introduces a known amount of the calibrant chemical into the calibrant chamber. In accordance with the present disclosure, systems and methods are provided for calibrating a mass spectrometer abundance scale. | 09-11-2014 |
| 20140252222 | AUTOMATIC GAIN CONTROL WITH DEFOCUSING LENS - A method and apparatus for performing mass spectrometry using an electron source, an ion trap, and a voltage-controlled lens located between the electron source and the ion trap. A controller applies a voltage to the lens. Features of the resulting output spectrum can be analyzed to determine whether to adjust the lens voltage. | 09-11-2014 |
| 20140252224 | MASS SPECTROMETER ION TRAP HAVING ASYMMETRIC END CAP APERTURES - An ion trap for a mass spectrometer is disclosed. The ion trap includes a ring electrode and first and second electrodes which are arranged on opposite sides of the ring electrode. The ring electrode and the first and second electrodes are configured to generate an electric field based on the received RF signal. The first electrode defines a first aperture and the second electrode defines a second aperture, the first aperture and the second aperture being asymmetric relative to each other and configured to generate a hexapole field. | 09-11-2014 |
| 20140264006 | Ion Trap with Radial Opening in Ring Electrode - Apparatuses and methods for performing mass analysis are disclosed. One such apparatus may include an ion trap device. The ion trap device may comprise a first end cap having a first aperture and a second end cap having a second aperture, wherein the first aperture and the second aperture may define an ejection axis. The ion trap device may also comprise a ring electrode substantially coaxially aligned between the first and second end caps. The ring electrode may include an opening extending along a radial direction of the ring electrode, wherein the radial direction is substantially perpendicular to the ejection axis. One such method may include ionizing a sample in an ion trap through an opening separating at least part of first and second ring sections of the ion trap and detecting ions ejected though an aperture on an end cap of the ion trap. | 09-18-2014 |
| 20140264013 | MASS SPECTROMETER HAVING AN EXTERNAL DETECTOR - A mass spectrometer system is disclosed. The mass spectrometer includes a vacuum chamber defining an enclosed evacuated space and an ion trap disposed in the enclosed space. The ion trap is configured to trap an ionized sample. The mass spectrometer further includes an ion detector coupled to the chamber at a location external to the chamber such that sample ions may exit the evacuated space and into the externally-coupled detector without loss of vacuum pressure. | 09-18-2014 |
| 20140299760 | MASS DEPENDENT AUTOMATIC GAIN CONTROL FOR MASS SPECTROMETER - Systems and methods for automatic gain control in mass spectrometers are disclosed. An exemplary system may include a mass spectrometer, comprising a lens configured to receive a supply of ions, and a mass analyzer. The mass analyzer may include an ion trap for trapping the supplied ions. The mass analyzer may also include an ion detector for detecting ions that exit the ion trap. The lens may focus the ions non-uniformly based on mass of the ions to compensate for space charge effects reflected in a measurement output of the mass spectrometer. An exemplary method may include focusing an ion beam into a mass analyzer. The method may also include obtaining a mass spectrum and identifying a space charge characteristic based on the mass spectrum. The method may further include defocusing the lens based on the identified space charge characteristic, wherein defocusing the lens is configured to divert lighter ions away from the entrance aperture. The method may include obtaining a mass spectrum of a defocused ion beam generated from the sample. | 10-09-2014 |
| 20150228468 | MASS DEPENDENT AUTOMATIC GAIN CONTROL FOR MASS SPECTROMETER - Systems and methods for automatic gain control in mass spectrometers are disclosed. An exemplary system may include a mass spectrometer, comprising a lens configured to receive a supply of ions, and a mass analyzer. The mass analyzer may include an ion trap for trapping the supplied ions. The mass analyzer may also include an ion detector for detecting ions that exit the ion trap. The lens may focus the ions non-uniformly based on mass of the ions to compensate for space charge effects reflected in a measurement output of the mass spectrometer. | 08-13-2015 |
| 20150235826 | SYSTEMS AND METHODS FOR CALIBRATING MASS SPECTROMETERS - Systems and methods are disclosed for calibrating mass spectrometers. In accordance with one implementation, a system comprises a calibrant chamber within a housing of a mass spectrometer. The system also comprises a permeation tube enclosed within the calibrant chamber, wherein the tube contains a calibrant chemical that continuously outgasses the calibrant chemical. The outgassed calibrant chemical may be introduced to the mass spectrometer for analysis. The system may also comprise a heating block to control the temperature of the calibrant chemical. The system may further comprise a valve that introduces a known amount of the calibrant chemical into the calibrant chamber. In accordance with the present disclosure, systems and methods are provided for calibrating a mass spectrometer abundance scale. | 08-20-2015 |
| 20150330961 | METHOD FOR DETECTING ORGANIC AND INORGANIC EXPLOSIVES - Methods, devices, and systems are disclosed for releasing a sample from a carrier medium. A method of releasing a sample from a carrier medium comprises treating a sample on a carrier medium with a first organic reagent, wherein when the sample contains at least one inorganic salt, the first organic reagent binds to a cation of the inorganic salt to produce both a first volatile compound and an isolated anion of the inorganic salt; treating the sample on the carrier medium with a second organic reagent, wherein the second organic reagent reacts with the isolated anion to produce a second volatile compound; and releasing the treated sample from the carrier medium, wherein when the first and the second volatile compounds are produced, the releasing step releases at least one of the first and second volatile compounds from the carrier medium. | 11-19-2015 |
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| 20130030706 | DETECTION OF DOWNHOLE VIBRATIONS USING SURFACE DATA FROM DRILLING RIGS - Disclosed is a method for estimating downhole lateral vibrations a drill tubular disposed in a borehole penetrating the earth or a component coupled to the drill tubular. The method includes rotating the drill tubular to drill the first borehole and performing a plurality of measurements in a time window of one or more parameters of the drill tubular at or above a surface of the earth during the rotating using a sensor. The method further includes estimating the downhole lateral vibrations using a processor that receives the plurality of measurements. | 01-31-2013 |
| 20130054203 | MODELING AND SIMULATION OF COMPLETE DRILL STRINGS - A method of predicting behavior of a drilling assembly includes: generating a mathematical representation of a geometry of each of a plurality of components of a drilling assembly, the plurality of components including a plurality of cutters and one or more additional components configured to at least one of: support the plurality of cutters and operably connect the plurality of cutters to the drill string, the one or more additional components including a drill bit crown; simulating one or more operating conditions incident on the drilling assembly representation, and simulating an interaction between the plurality of components and an earth formation; and predicting physical responses of the drilling assembly representation to the one or more conditions. | 02-28-2013 |
| 20130151219 | MULTI-PARAMETER BIT RESPONSE MODEL - A method of generating a directional response of a drill bit based on one or more drilling parameters includes performing actual or simulated tests with a drill bit in a test material having a strength under different experimental drilling parameters and recording the results of the plurality of tests. A representation of an expected directional response of the drill bit is formed based on the results. Current drilling parameters are receiving current drilling parameters at a computing device and the directional response is generated based on the current drilling parameters by utilizing the representation. | 06-13-2013 |
| 20130248256 | DRILL BIT OPTIMIZATION BASED MOTION OF CUTTERS - A method of designing a drill bit includes: defining a representation of a first drill bit including at least a first cutter having a first face, the first cutter being disposed on the representation of the first drill bit in a first orientation; simulating in a first simulation on a computing device off-axis rotation of the first drill bit in a simulated subterranean formation; determining that the first face included, during the first simulation, a first face orientation direction that was oriented different than a face cutting direction by an amount that exceeds a predetermined threshold; and defining the first drill bit such that the first cutter is disposed in a second orientation. | 09-26-2013 |
| 20140122034 | DRILL BIT BODY RUBBING SIMULATION - A method of predicting behavior of a drilling assembly includes generating, by a processor, a mathematical representation of a geometry of drill bit that includes a plurality of earth contacting portions, the plurality of earth contacting portions including a plurality of cutters and one or more additional components; estimating, with a separate model for each earth contacting portion, contact with the earth formation during a drilling operation; and estimating one or more forces on the one or more earth contact portions during the drilling operation based on the estimated contact. | 05-01-2014 |
| 20140332285 | FORMATION-ENGAGING ELEMENT PLACEMENT ON EARTH-BORING TOOLS AND RELATED METHODS - Earth-boring tools include a cutting element positioned on a drill bit body at a radial distance from a longitudinal axis thereof. At least two formation-engaging elements are positioned at the same radial distance from the longitudinal axis as the cutting element. The formation-engaging elements are recessed from cutting profile of the cutting element by a distance within about 10% of d, wherein d=(α*x)/(1800*y), where α is an angle between the formation-engaging element and the cutting element, x is a rate of penetration of the drill bit body, and y is a rotation speed of the drill bit body. Additional earth-boring tools include at least one cutting element and at least two formation-engaging elements recessed from a cutting profile of the at least one cutting element at a common angle. Methods relate to forming such earth-boring tools. | 11-13-2014 |
| 20150142403 | AXIAL MOTION DRILL BIT MODEL - A method for predicting an amount of axial motion of a drill bit having one or more cutters for drilling formation rock includes: receiving lithology data for the formation rock; receiving drilling parameters; calculating confined compressive strength (CCS) of the rock using the received information; calculating an area of cut into the formation rock by each of the one or more cutters; calculating an effective back rake of each of the one or more cutters; calculating a force applied to each of the one or more cutters using the CCS, the area of cut and the effective back rake of the one or more cutters, and by accounting for an orientation of each cutter with respect to a surface of the rock to be cut; and summing the calculated forces applied to each of the one or more cutters to calculate the weight on bit and torque on bit. | 05-21-2015 |
| 20150142404 | LATERAL MOTION DRILL BIT MODEL - A method for predicting a change in lateral displacement with a change in axial displacement of a drill bit drilling in a formation rock includes: constructing a virtual representation of the drill bit and the formation rock, the drill bit having a gage pad configured to remove rock by wearing or crushing the rock during moving contact and a cutter configured to cut into the rock during moving contact with the rock; adjusting lateral penetration depth until rock reactive force equals a side force applied to the drill bit to provide an adjusted lateral penetration depth; removing formation rock to where the pad and the cutters contact the rock at the adjusted lateral penetration depth and to a selected axial displacement of the drill bit; moving the drill bit in a drilling direction to the end of the currently drilled borehole; and iterating the adjusting, the removing, and the moving. | 05-21-2015 |
| 20150142406 | DIRECTIONAL DRILL AHEAD SIMULATOR: DIRECTIONAL WELLBORE PREDICTION USING BHA AND BIT MODELS - A method for predicting a path of a borehole that will be drilled in a rock formation by a bottomhole assembly (BHA) having a drill bit includes: constructing a model of the BHA; calculating confined compressive strength of the rock formation using an axial motion drill bit model that receives drilling parameter, drill bit design and lithology information; calculating lateral motion of the drill bit using a lateral motion drill bit model; calculating a ratio of lateral motion to axial motion using the lateral motion drill bit model; calculating an inclination angle and an azimuthal direction of the BHA using a BHA steering model that receives the ratio; and iterating the above steps by updating the BHA model to include extending the borehole an incremental distance in the direction of the inclination angle and the azimuthal direction and displacing the BHA the incremental distance in the extended borehole. | 05-21-2015 |
| 20160047206 | METHODS OF SELECTING BOTTOM HOLE ASSEMBLIES COMPRISING EARTH-BORING TOOLS, OF IMPROVING DRILLING OPERATIONS, AND OF IMPROVING DRILLING PLANS BASED ON DRILLING SIMULATIONS - Methods of evaluating performance of simulated drilling operations may involve accepting characteristics of an earth formation. A drill path, a plurality of quality evaluation standards, and selection of a bottom hole assembly (BHA) and at least one earth-boring tool may be accepted. A drilling operation attempting to follow the drill path using the BHA and the drill bit may be simulated. Performance of the BHA and the drill bit in the drilling operation may be evaluated relative to the quality evaluation standards. At least one aspect of the simulated drilling operation may be changed, and simulation of the drilling operation, performance evaluation, and change of the aspects of the drilling operation may be iterated. Performance of each drilling operation may be compared to the other drilling operations, and an improved aspect of a drilling operation may be output relative to the comparative performance of the drilling operations. | 02-18-2016 |
| 20160097237 | DRILL BIT WITH EXTENDABLE GAUGE PADS - A drill bit for use in a wellbore is disclosed, including a bit body having a longitudinal axis; and at least one moveable member associated with a lateral extent of the bit body, wherein the at least one moveable member is configured to translate in a member axis that is substantially longitudinal. Further, a method of drilling a wellbore is disclosed, including providing a drill bit including a bit body having a longitudinal axis and at least one movable member associated with a lateral extent of the bit body; conveying a drill string into a formation, the drill string having the drill bit at the end thereof; drilling the wellbore using the drill string; and selectively translating at least one movable member in a member axis that is substantially longitudinal. | 04-07-2016 |
