Soubrier
Fabienne Soubrier, Thieis FR
Patent application number | Description | Published |
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20090252713 | CIRCULAR DNA MOLECULE HAVING A CONDITIONAL ORIGIN OF REPLICATION, PROCESS FOR THEIR PREPARATION AND THEIR USE IN GENE THERAPY - A circular DNA molecule, useful for gene therapy, comprising at least one nucleic acid sequence of interest, characterised in that the region allowing the replication thereof has an origin of replication with a functionality in a host cell that requires the presence of at least one specific protein foreign to said host cell. A method for preparing same, cells incorporating said DNA molecules and uses thereof in gene therapy are also described. | 10-08-2009 |
Fabienne Soubrier, Paris FR
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20090149406 | Plasmid PXL3179 or NV1FGF - A prokaryotic recombinant host cell comprising a heterologous replication initiation protein that activates a conditional origin of replication and an extrachromosomal DNA molecule comprising a heterologous therapeutic gene and a conditional origin of replication whose functionality in the prokaryotic recombinant host cell requires a replication initiating protein which is foreign to the host cell is described. The host cell may comprise a pir gene having at least one mutation, which may occur in the pir gene copy number control region, the pir gene leucine zipper-like motif, or the pir gene DNA binding region. | 06-11-2009 |
20120282637 | POLYPEPTIDES FOR BINDING TO THE RECEPTOR FOR ADVANCED GLYCATION ENDPRODUCTS AS WELL AS COMPOSITIONS AND METHODS INVOLVING - The present invention relates to a polypeptide or polypeptide complex comprising at least the two amino acid sequences arranged to allow for specific binding to the “receptor for advanced glycation endproducts” (RAGE), one or more nucleic acid(s) coding for the polypeptide or polypeptide complex, a cell producing an antibody against RAGE, a pharmaceutical composition comprising at least one polypeptide or nucleic as defined above, optionally for treating a RAGE-related disease or disorder and a method of diagnosing a RAGE-related disease or disorder. | 11-08-2012 |
20140046032 | METHOD OF PRODUCTION OF SIALYLATED ANTIBODIES - The present invention relates to a method for producing an IgG antibody, wherein at least 80% of the said antibody comprises a complex, bi-antennary oligosaccharide, which contains two sialic acid residues, attached to the Fc domain of the antibody. The said method comprises the steps of introducing a mutation in the Fc domain of the antibody, and expressing the mutant antibody in a cell which expresses a galactosyltransferase and a sialyltransferase activity. | 02-13-2014 |
Fabienne Soubrier, Thiais FR
Patent application number | Description | Published |
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20090130674 | Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy - A prokaryotic recombinant host cell comprising a heterologous replication initiation protein that activates a conditional origin of replication and an extrachromosomal DNA molecule comprising a heterologous therapeutic gene and a conditional origin of replication whose functionality in the prokaryotic recombinant host cell requires a replication initiating protein which is foreign to the host cell is described. The host cell may comprise a pir gene having at least one mutation, which may occur in the pir gene copy number control region, the pir gene leucine zipper-like motif, or the pir gene DNA binding region. | 05-21-2009 |
Jean-Claude Soubrier, Romagnat FR
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20130186556 | Method for Manufacturing Bead Wire for Producing a Tire - In the method for manufacturing a bead wire intended for producing a tire, the bead wire comprises a coating that forms a region that overlaps itself in a circumferential direction of the bead wire. The bead wire is pressed using at least three jaws ( | 07-25-2013 |
Stéphane Soubrier, Montreuil FR
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20150240754 | ENGINE CONTROL VALVE WITH IMPROVED SEALING - Engine control valve having a body delimiting an internal duct and comprising a flap ( | 08-27-2015 |