Sontheimer
Andrew B. Sontheimer, Plano, TX US
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20090231674 | System and Method for Hinge Memory Mitigation - System and method for reducing failures due to hinge memory in a microdisplay display system. A preferred embodiment includes setting the state of each micromirror in a digital micromirror device based on an image being displayed, recording a usage history for the micromirrors, and providing a sequence of states to each micromirror when the display system is in an inactive mode. The sequence of states provided to a micromirror is based on the micromirror's usage history. The operation of the micromirrors while a display system containing the digital micromirror device is not in active use can help to reverse or eliminate hinge memory, thereby extending the lifetime of the digital micromirror device. | 09-17-2009 |
Erik J. Sontheimer, Kenilworth, IL US
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20100076057 | TARGET DNA INTERFERENCE WITH crRNA - The present invention provides methods, systems, and compositions for interfering with the function and/or presence of a target DNA sequence in a eukaryotic cell (e.g., located in vitro or in a subject) using crRNA and CRISPR-associated (cas) proteins or cas encoding nucleic acids. The present invention also relates to a method for interfering with horizontal gene transfer based on the use of clustered, regularly interspaced short palindromic repeat (CRISPR) sequences. | 03-25-2010 |
20140349405 | RNA-DIRECTED DNA CLEAVAGE AND GENE EDITING BY CAS9 ENZYME FROM NEISSERIA MENINGITIDIS - Disclosed are components and methods for RNA-directed DNA cleavage and gene editing. The components include and the methods utilize a Cas9 protein from | 11-27-2014 |
Harald Sontheimer, Birmingham, AL US
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20090117031 | Methods for Treating Glioma - The present disclosure provides for method of treatment and/or prevention of disease states that require cystine for maintenance or progression of the disease state. In addition, methods for screening and identifying novel therapeutic agents useful in the treatment of such disease states are described. In one embodiment, the disease state is a cancer, such as, but not limited to, glioma. In this embodiment, methods for the treatment and prevention of glioma by inhibiting cystine uptake or decreasing intracellular cystine concentrations are provided. The present disclosure teaches that glioma cells are dependent on system Xc for cystine uptake. Pharmacological inhibition of system Xc causes a rapid depletion of intracellular glutathione, resulting in decreased cell growth. In contrast, non-malignant astrocytes and cortical neurons remain viable in the presence of Xc inhibitors and continue to take up cystine via alternate amino acid transporters. | 05-07-2009 |
Harald W. Sontheimer, Birmingham, AL US
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20100215576 | DIAGNOSIS AND TREATMENT OF NEUROECTODERMAL TUMORS - The present invention provides fusion proteins for the detection and treatment of neuroectodermal tumors. Previous work demonstrated that chlorotoxin is specific for glial-derived or meningioma-derived tumor cells. The current invention has extended the use of chlorotoxin-cytotoxin fusion proteins to treat the whole class neuroectodermal tumors such as gliomas, meningiomas, ependymonas, medulloblastomas, neuroblastomas, gangliomas, pheochromocytomas, melanomas, PPNET's, small cell carcinoma of the lung, Ewing's sarcoma, and metastatic tumors in the brain. Also, diagnostic methods are provided for screening neoplastic neuroectodermal tumors. | 08-26-2010 |
20120183544 | DIAGNOSIS AND TREATMENT OF NEUROECTODERMAL TUMORS - The present invention provides fusion proteins for the detection and treatment of neuroectodermal tumors. Previous work demonstrated that chlorotoxin is specific for glial-derived or meningioma-derived tumor cells. The current invention has extended the use of chlorotoxin-cytotoxin fusion proteins to treat the whole class neuroectodermal tumors such as gliomas, meningiomas, ependymonas, medulloblastomas, neuroblastomas, gangliomas, pheochromocytomas, melanomas, PPNET's, small cell carcinoma of the lung, Ewing's sarcoma, and metastatic tumors in the brain. Also, diagnostic methods are provided for screening neoplastic neuroectodermal tumors. | 07-19-2012 |
20140248291 | Modulation of Cellular Migration - Methods, kits, and compositions are provided for addressing cancer through the interaction of bradykinin (BK) and the bradykinin-2-receptor (B2R). This interaction controls cellular invasion, as has been unexpectedly observed in glioma cells, A composition is provided for the treatment of cancer by disrupting this interaction using an inhibitor or BK or B2R that can. be administered to the subject. Diagnostic processes are provided, involving measuring levels of BK or B2R to determine the potential for cancer (or to determine the invasive potential of a given cancer). Modulators of BK. and B2R may be used to modulate cellular migration, both in vivo and in vitro. Potential modulators of cellular migration can be screened by measuring the effect of the potential modulator on BK or B2R, | 09-04-2014 |
Paul Sontheimer, Waseca, MN US
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20090265057 | USB Isolation for Vehicle Communication Interface - The present invention relates generally to an automotive diagnostic tool which facilitates data communications between an automobile and diagnostic device, such as a personal computer. More particularly, the present invention relates to electrically isolating the data communications using a Vehicle Communication Interface (VCI) device situated between an automobile's communication diagnostic port and the personal computer. The VCI contains logic circuitry to translate the automobile's On Board Diagnostic (OBD II) signals to an embedded Ethernet controller. Ethernet signals are then non-galvanicly exchanged with an Ethernet to USB controller with an Ethernet transformer. A personal computer is attached via a USB cable to the VCI's Ethernet to USB Controller, permitting information exchange between the automobile and the personal computer. | 10-22-2009 |
20100318259 | VEHICLE COMMUNICATIONS INTERFACE AND METHOD OF OPERATION THEREOF - A vehicle communication interface (VCI) that allows for a single communications protocol to be used between a software application and a plurality of software drivers that are connected to physical interfaces of the VCI. Also, a method of communicating with a vehicle using a host system such as a personal computer. The method also makes use of a single communications protocol between a software application that processes information received from a vehicle and a plurality of software drivers. | 12-16-2010 |
Paul Sontheimer, Owatonna, MN US
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20100153039 | Apparatus and Method for Testing a Power Source - A method and apparatus for communicating a battery information to a remote device or database. The battery tester and/or charger can communicate with a wired or wireless connection to the remote device. Battery indentifying information, test results and warranty information can be communicated to the remote device or database. | 06-17-2010 |
20130019043 | Vehicle Communications Interface and Method of Operations Thereof - A vehicle communication interface (VCI) that allows for a single communications protocol to be used between a software application and a plurality of software drivers that are connected to physical interfaces of the VCI. Also, a method of communicating with a vehicle using a host system such as a personal computer. The method also makes use of a single communications protocol between a software application that processes information received from a vehicle and a plurality of software drivers. | 01-17-2013 |
Peter Sontheimer, Baierbrunn DE
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20120061815 | POWER SEMICONDUCTOR MODULE HAVING SINTERED METAL CONNECTIONS, PREFERABLY SINTERED SILVER CONNECTIONS, AND PRODUCTION METHOD - A power semiconductor module having a substrate ( | 03-15-2012 |
Tobias Sontheimer, Berlin DE
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20140213044 | METHOD FOR PRODUCING PERIODIC CRYSTALLINE SILICON NANOSTRUCTURES - A method for producing periodic crystalline silicon nanostructures of large surface area by: generating a periodic structure having a lattice constant of between 100 nm and 2 μm on a substrate, the substrate used being a material which is stable at up to at least 570° C., and the structure being produced with periodically repeating shallow and steep areas/flanks, and, subsequently, depositing silicon by directed deposition onto the periodically structured substrate, with a thickness in the range from 0.2 to 3 times the lattice constant, or 40 nm to 6 μm, at a substrate temperature of up to 400° C., followed by thermally treating the deposited Si layer to effect solid-phase crystallization, at temperatures between 570° C. and 1400° C., over a few minutes up to several days, and optionally subsequently wet-chemically selective etching to remove resultant porous regions of the Si layer. | 07-31-2014 |