Smith, MD
Adam Smith, Pasadena, MD US
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20130260886 | Multi-sensory Learning Game System - A multi-sensory feedback learning system is provided for helping children learn outside of the classroom. The system includes a depressible game controller mat that is in communication with a monitor or television. Housed within the controller mat are components necessary to store and run a learning video game. Games involving alphabetical characters, numerical characters, and foreign languages are available for children to play via the system. Prompts are displayed on the monitor or audibly through a monitor coupled audio feedback device. Children respond to the prompt by depressing alphanumeric indicia on the controller mat, thereby making answer selections. Feedback on answers is provided in the form of visual, audible, and tactile output from the system. Correct answers are rewarded with points, and a child's total score can be tracked for progress comparison. | 10-03-2013 |
Allison A. Smith, Baltimore, MD US
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20080264519 | Power Planer - A planing machine including a base, at least two support columns disposed on the base, and a carriage assembly carrying a cutterhead. The carriage assembly may be mounted on the support columns. At least one of the base and the carriage assembly is movable vertically towards the other of the base and the carriage assembly. The planing machine may have panel mounted on at least one of the base and the carriage assembly and extending between the carriage assembly and the base housing for preventing user contact with the cutterhead. | 10-30-2008 |
20090021090 | Power Tools With Motor Having a Multi-Piece Stator - A power tool has a motor having a stator made by separately forming pole pieces, return path pieces and field coils. The field coils are placed over necks of the pole path pieces and the return path pieces are affixed to the pole pieces. An armature having an outside diameter of at least 0.625 the outside diameter of the stator is placed in the stator. The field coils may be formed so that they extend beyond pole tips of the pole pieces. | 01-22-2009 |
20110115314 | POWER TOOLS WITH MOTOR HAVING A MULTI-PIECE STATOR - A power tool has a motor having a stator made by separately forming pole pieces, return path pieces and field coils. The field coils are placed over necks of the pole path pieces and the return path pieces are affixed to the pole pieces. An armature having an outside diameter of at least 0.625 the outside diameter of the stator is placed in the stator. The field coils may be formed so that they extend beyond pole tips of the pole pieces. | 05-19-2011 |
20120248902 | POWER TOOL WITH MOTOR HAVING A MULTI-PIECE STATOR - A power tool has a motor having a stator made by separately forming pole pieces and field coils. The field coils are placed over necks of the pole path pieces. An armature has an outside diameter of at least 0.625 the outside diameter of the stator is placed in the stator. The housing has a girth of 200 mm or less with the motor wound to provide a maximum watts out to housing girth ratio of at least 5 maximum watts outs to 1 mm of housing girth. The field coils may be formed so that they extend beyond pole tips of the pole pieces. | 10-04-2012 |
Allison A. Smith, Perry Hall, MD US
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20090199928 | POWER PLANER - A planing machine including a base, at least two support columns disposed on the base, and a carriage assembly carrying a cutterhead. The carriage assembly may be mounted on the support columns. At least one of the base and the carriage assembly is movable vertically towards the other of the base and the carriage assembly. The planing machine may have panel mounted on at least one one of the base and the carriage assembly and extending between the carriage assembly and the base housing for preventing user contact with the cutterhead. | 08-13-2009 |
Barry A. Smith, North East, MD US
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20110156371 | Fifth wheel locking pin - The Fifth Wheel Locking Pin is a pin fitted with a lock, providing security for a trailer. The device consists of a hardened steel bar one-half inch in diameter, and approximately sixteen to twenty inches in length. The proximal end of the bar is a T-shaped handle made from the same stock. The distal end of the bar is fitted with a lock. The end of the bar is machined to fit the lock, and the bar is grooved, enabling the lock to mate with the bar through pins that extend from the lock into the grooves. The lock is mechanically operated by the turn of a key, extending or retracting the pins. | 06-30-2011 |
Carolyn W. Smith, Elkton, MD US
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20100319103 | Sleepwear having a skirt - Sleepwear that increases comfort and flexibility is disclosed. The sleepwear includes an upper garment and a skirt that allows movement of the body of a user without bunching of material or discomfort. The skirt includes a slit or a plurality of slits to allow movement of the fabric and to increase air flow over the body of the user. | 12-23-2010 |
Cecil D. Smith, Woodbine, MD US
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20110013911 | HIGH-SPEED OPTICAL TRANSPONDER SYSTEMS - The present disclosure provides high-speed wavelength division multiplexing (WDM) transponders (e.g., 10 Gb/s, 40 Gb/s, 100 Gb/s, and beyond) that receive one or more optical signals and convert and/or remodulate the received optical signals onto a newly generated optical channel along with overhead processing/addition, forward error correction, and the like. In general, the transponders of the present invention include a client-side and a line-side, each with bi-directional optical transmission. The transponders provide an effective mechanism to support WDM networks that are transparent to the client-side. | 01-20-2011 |
Cecil D. Smith, Severna Park, MD US
Patent application number | Description | Published |
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20090041471 | REMODULATING CHANNEL SELECTORS FOR WDM OPTICAL COMMUNICATION SYSTEMS - The present invention provides a remodulating channel selector for a wavelength division multiplexed optical communication system. The remodulating selector receives a WDM input signal, selects a particular optical channel from the WDM signal and places the information from the selected signal onto a newly-generated optical output signal. The wavelength of the output optical signal can be the same as or different from one of the optical channels which comprises the WDM input signal. When used in a WDM optical communication system with remodulators at the transmission input, the remodulating selectors provide complete control over the interfaces with optical transmitters and receivers, permitting use with a broad range of optical equipment. | 02-12-2009 |
20100329682 | REMODULATING CHANNEL SELECTORS FOR WDM OPTICAL COMMUNICATION SYSTEMS - The present invention provides a remodulating channel selector for a wavelength division multiplexed optical communication system. The remodulating selector receives a WDM input signal, selects a particular optical channel from the WDM signal and places the information from the selected signal onto a newly-generated optical output signal. The wavelength of the output optical signal can be the same as or different from one of the optical channels which comprises the WDM input signal. When used in a WDM optical communication system with remodulators at the transmission input, the remodulating selectors provide complete control over the interfaces with optical transmitters and receivers, permitting use with a broad range of optical equipment. | 12-30-2010 |
David F. Smith, Maryland, MD US
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20110286508 | TECHNIQUES AND SYSTEMS FOR COMMUNICATIONS BASED ON TIME REVERSAL PRE-CODING - Techniques, apparatuses and systems for providing communications based on time reversal of a channel impulse response of a pulse in a transmission channel between a transmitter and a receiver to enhance reception and detection of a pulse at the receiver against various effects that can adversely affect and complicate the reception and detection of the pulse at the receiver. | 11-24-2011 |
David F. Smith, Ellicott City, MD US
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20100310251 | Optical Transmission Systems, Devices, and Methods - An optical system with a first and second network tiers. The first network tier includes a plurality of major nodes optically interconnected by at least one transmission path. The second network tier includes a plurality of minor nodes disposed along the transmission path and the minor nodes are connected to at least one of the major nodes. The minor node is configured to transmit all traffic to an adjacent major node, and the major nodes are configured to transmit to and receive information from other major nodes and minor nodes on transmission paths connected to the major node. | 12-09-2010 |
20110170862 | OPTICAL COMMUNICATIONS IN RECIPROCAL NETWORKS BASED ON WAVELENGTH SWITCHING - Techniques, apparatus and systems to provide packet transmission in reciprocal transmission architecture networks for optical communications. | 07-14-2011 |
20110229145 | OPTICAL COMMUNICATIONS IN AMPLIFIED RECIPROCAL NETWORKS - Techniques, apparatus and systems to provide carrier signal transmission in reciprocal transmission architecture networks for optical communications. | 09-22-2011 |
20120155515 | TECHNIQUES AND SYSTEMS FOR PROVIDING DATA OVER POWER IN COMMUNICATIONS BASED ON TIME REVERSAL - Techniques, apparatuses and systems for providing communications based on time reversal of a channel impulse response of a pulse in a transmission channel between a transmitter and a receiver to enhance reception and detection of a pulse at the receiver against various effects that can adversely affect and complicate the reception and detection of the pulse at the receiver. | 06-21-2012 |
20120257660 | TECHNIQUES AND SYSTEMS FOR WIRELESS COMMUNICATIONS - Techniques, apparatus and systems for providing radio frequency wireless communications based on time reversal of the channel impulse response of an RF pulse in a transmission channel between an RF transmitter and an RF receiver to enhance reception and detection of an RF pulse at the RF receiver against various effects that can adversely affect and complicate the reception and detection of the RF pulse at the RF receiver. | 10-11-2012 |
20130223503 | REDUCING SIGNAL DEGRADATION IN WIRELESS COMMUNICATIONS BASED ON TIME REVERSAL - Techniques, apparatus and systems for providing radio frequency wireless communications based on time reversal of the channel impulse response of an RF pulse in a transmission channel between an RF transmitter and an RF receiver to enhance reception and detection of an RF pulse at the RF receiver against various effects that can adversely affect and complicate the reception and detection of the RF pulse at the RF receiver. | 08-29-2013 |
Dennis Smith, Ellicott City, MD US
Patent application number | Description | Published |
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20100298913 | DEVICE AND METHOD FOR TREATMENT OF TISSUE ADJACENT A BODILY CONDUIT BY THERMOCOMPRESSION - A method and apparatus of treating tissue adjacent to a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema employs the circulation of warmed fluid to maintain the temperature of the bodily conduit walls and compresses the tissue to be treated to increase the effectiveness of the irradiated heat. An energy-emitting source containing catheter is inserted in a bodily conduit and is positioned in a region of the tissue to be treated so that the energy-emitting source radiates energy to the tissue to be treated. Fluid warmed to over 30° C. is circulated into and through the catheter to warm walls of the bodily conduit adjacent the catheter. The circulated fluid inflates a balloon to a pressure to compress the tissue to be treated. The combination of warmed fluid over 30° C. being circulated adjacent the bodily conduit to maintain the warmth in its walls and the compression of the tissue to be treated enables a natural stent to be formed that remains after the catheter and compression balloon is removed. | 11-25-2010 |
20120088960 | BOWEL PACKING DEVICE HAVING A TETHER - A kit for packing the bowels of a subject. The kit comprises an elastomeric bowel packing device manually positioned within the subject to retain the bowels of the subject in an operational displaced position and to provide a surgical operational space; and an elongate tether having a distal end coupled to the device via an attachment arrangement. | 04-12-2012 |
20120088961 | BOWEL PACKING DEVICE HAVING A SUPPORT STRUCTURE - An elastomeric device for packing the bowels of a subject comprising: a central portion and one or more flaps collectively manually positionable within the subject to retain the bowels of the subject in an operational, displaced position and to provide a surgical operational space; and a support structure disposed in at least one of the central portion and the flaps configured to provide rigidity to the device. | 04-12-2012 |
20120143010 | COLLAPSIBLE BARRIER FOR ORGAN RETENTION AND METHOD OF USE - A device for human organ packing in a laproscopic surgical procedure, including an expandable barrier configured to be laproscopically implanted into a human abdominal cavity such that a side of the expandable barrier interfaces with organs in the abdominal cavity, thereby forming a barrier between the organs and a region of the abdominal cavity on an opposing side of the barrier relative to the organs, wherein at least a portion of the barrier is configured to be controllably transformed from a first state to a second state, wherein when in the second state the barrier is in a more rigid state relative to the first state. | 06-07-2012 |
20120303103 | DEVICE AND METHOD FOR TREATMENT OF TISSUE ADJACENT A BODILY CONDUIT BY THERMOCOMPRESSION - A method and apparatus of treating tissue adjacent to a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema employs the circulation of warmed fluid to maintain the temperature of the bodily conduit walls and compresses the tissue to be treated to increase the effectiveness of the irradiated heat. An energy-emitting source containing catheter is inserted in a bodily conduit and is positioned in a region of the tissue to be treated so that the energy-emitting source radiates energy to the tissue to be treated. Fluid warmed to over 30° C. is circulated into and through the catheter to warm walls of the bodily conduit adjacent the catheter. The warmed circulated fluid inflates a balloon to a pressure to compress the tissue to form a natural stent that remains after the catheter and compression balloon are removed. | 11-29-2012 |
20140024886 | BOWEL PACKING DEVICE HAVING A SUPPORT STRUCTURE - An elastomeric device for packing the bowels of a subject comprising: a central portion and one or more flaps collectively manually positionable within the subject to retain the bowels of the subject in an operational, displaced position and to provide a surgical operational space; and a support structure disposed in at least one of the central portion and the flaps configured to provide rigidity to the device. | 01-23-2014 |
20140031614 | BOWEL PACKING DEVICE HAVING A TETHER - A kit for packing the bowels of a subject. The kit comprises an elastomeric bowel packing device manually positioned within the subject to retain the bowels of the subject in an operational displaced position and to provide a surgical operational space; and an elongate tether having a distal end coupled to the device via an attachment arrangement. | 01-30-2014 |
Doran Smith, Rockville, MD US
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20130193963 | SURFACE SCANNING RADIO FREQUENCY ANTENNA FOR MAGNETIC RESONANCE FORCE MICROSCOPY - A probe for scanning a surface of an arbitrarily sized sample in magnetic resonance force microscopy comprising a magnetic sensor having a support element coupled to a magnetic particle, an RF antenna, at least partially circumscribing the magnetic sensor, for emitting an RF magnetic field across a portion of the sample and an optical sensor, positioned proximate the magnetic sensor, for detecting displacement of the support element. | 08-01-2013 |
20130193967 | METHOD FOR TAKING DATA FROM A RESONANCE FORCE MICROSCOPY PROBE - A control apparatus for extracting data from an MRFM system in accordance with exemplary embodiments of the present invention comprising a visualization controller for controlling operation of the MRFM system, an initialization module, coupled to the visualization controller, for retrieving initialization data from a data source, a data collection module, coupled to the visualization controller, for extracting data from the MRFM system and an imaging module for generating image data based on the extracted data. | 08-01-2013 |
20130198913 | APPARATUS FOR MECHANICALLY ROBUST THERMAL ISOLATION OF COMPONENTS - An apparatus for scanning over a surface of an arbitrarily sized sample in magnetic resonance force microscopy comprising a cantilever for holding a magnetic particle at the cantilever tip, an RF antenna, positioned around the cantilever, for emitting an RF magnetic field across a portion of the sample causing spin of particles in the sample to reverse attracting and opposing the magnetic particle at the cantilever tip, an optical fiber, positioned close to the cantilever tip, for measuring displacements of the cantilever tip where the RF antenna, cantilever, magnetic particle and optical fiber are in fixed positions relative to each other and the sample is positionable according to a sample stage. | 08-01-2013 |
20130198914 | APPARATUS FOR PERFORMING MAGNETIC RESONANCE FORCE MICROSCOPY ON LARGE AREA SAMPLES - An apparatus for performing magnetic resonance force microscopy on one or more large area samples comprising a base plate, one or more heat sink plates coupled to the base plate, one or more suspension mechanisms coupled to the base plate and the heat sink plates, a probe head suspended from the one or more suspension mechanisms for scanning the one or more samples and a sample cylinder comprising a sample stage coupled to the probe head for sample positioning and an outer drum for isolating the sample stage. | 08-01-2013 |
Emily E. Smith, Baltimore, MD US
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20100323913 | Purification and Concentration of Proteins and DNA from a Complex Sample Using Isotachophoresis and a Device to Perform the Purification - A method of simultaneously co-purifying and concentrating nucleic acid and protein targets is described. The method includes automation of the entire sample preparation process, performed by having an analyst add a sample into a device that performs all of the steps necessary to prepare a sample for analysis. The method provides for samples that are not split during the sample preparation process and where common purification methods can be used for purifying multiple analytes. | 12-23-2010 |
20140332389 | KIT FOR CO-PURIFICATION AND CONCENTRATION OF DNA AND PROTEINS USING ISOTACHOPHORESIS - A kit for separating and concentrating nucleic acid and protein targets includes labeled reagents which affect simultaneous co-purification and concentration of a nucleic acid and a protein, a gel isotachophoresis separation unit to which a sample comprising the nucleic acid and the protein is added, a detection unit for the detection of the presence of the nucleic acid and the protein, and instructions for use. The gel electrophoresis includes a gel box having a negative electrode side and a positive electrode side, the negative electrode side being filled with a first buffer comprising 2-Hydroxy-N-(tris(hydroxymethyl)methyl)-3-aminopropanesulfonic acid buffer and the positive electrode side being filled with a second buffer being different than the first buffer. The gel isotachophoresis separation is configured to subject the sample to isotachophoresis using a voltage. | 11-13-2014 |
Gabriel L. Smith, Ellicott City, MD US
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20120266770 | APPARATUS AND METHOD FOR SUSPENSION WICKING OF NANOPARTICLES INTO MICROCHANNELS - A method of forming a device on a substrate comprising creating a depository and at least one attached capillary; the depository being of millimeter scale; providing a liquid containing particles in the range 1 nanometer to 1 millimeter; depositing into the depository the liquid containing particles which flows into at least one capillary by capillary action; evaporating the liquid such that the particles form an agglomerate beginning at the end of the at least one capillary with a substantially uniform distribution of the particles within the agglomerate; which is used to form a device. A microelectronic integrated circuit device comprising a substrate; a depository coupled to said substrate, the depository being formed by at least one wall adjacent to the substrate; at least one capillary channel coupled to at least one depository that is formed by walls adapted to be filled with a liquid (by capillary action) comprising nanoparticles. | 10-25-2012 |
20140299967 | ELECTRONIC DEVICE STRUCTURE AND METHOD OF MAKING ELECTRONIC DEVICES AND INTEGRATED CIRCUITS USING GRAYSCALE TECHNOLOGY AND MULTILAYER THIN-FILM COMPOSITES - A physical structure and a method for forming a electronic devices on a substrate comprising: providing a substrate; forming a plurality of layers on the substrate, the layers comprising at least two layers of conducting material and a layer of insulating material therebetween; depositing photoresist material onto predetermined regions of the plurality of layers, the photoresist material varying in thickness; utilizing gray scale illumination on the photoresist material; removing a portion of the layers using physical etching to expose predetermined portions of the conducting layers. Optionally, the photoresist may be utilized on a plurality of discrete electronic devices concurrently, such that the gray scale illumination is conducted on a plurality of discrete electronic devices concurrently. Similarly, the physical etching may be conducted on the discrete electronic devices concurrently; removing different thicknesses of material concurrently. Also claimed is a product made by the claimed method. | 10-09-2014 |
Gabriel L. Smith, Odenton, MD US
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20140076696 | THREE-AXIS ACCELERATION SWITCH ARRAY - An acceleration switch array having at least two acceleration switches. Each acceleration switch includes a substrate, an anchor attached to the substrate, an electrically conductive mass disposed around the anchor and secured to the anchor by a spring assembly which permits movement of the mass relative to the anchor, and a plurality of electrical contacts positioned at circumferentially spaced positions around and outwardly from the mass. These electrical contacts are aligned along at least one orthogonal axis. A resistor array is electrically connected between the electric contacts of each acceleration switch for each orthogonal axis so that, upon contact between the mass and any of the electrical contacts, an electrical resistance is presented at an output terminal that is unique for each electrical contact for each acceleration switch. | 03-20-2014 |
Gail Smith, Gaithersburg, MD US
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20100226932 | Adjuvant and Vaccine Compositions - Abstract Compositions comprising an emulsion and aluminum salt nano-/micro-particles surface stabilized with at least one surfactant are useful as immunological adjuvants. The emulsion of these compositions comprises at least one oil; at least one surfactant; a plurality of surfactant vesicles; optionally at least one sterol; and an aqueous phase. The present invention also provides vaccines comprising one or more antigens combined with the emulsion and surface stabilized aluminum salt particles of the present invention, or one or more antigens combined with non-ionic surfactant vesicles. | 09-09-2010 |
Gale Smith, Gaithersburg, MD US
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20100196419 | ENHANCEMENT OF GLYCOPROTEIN INCORPORATION INTO VIRUS-LIKE PARTICLES - Embodiments of the present disclosure encompasses virus-like particles, methods of making virus-like particles, including expression vectors, wherein the virus-like particles may comprise enhanced levels of capsid-bound a chimeric HN-Env polypeptide compared to VLPs derived from unmodified HIV-env polypeptides. Embodiments of the virus-like particle may have Env-specific epitopes exposed on the outer surface thereof. In one embodiment, the Env-specific epitopes exposed on the outer surface of the virus-like particle may specifically bind with an anti-HIV-Env specific antibody. Embodiments of the disclosure further includes methods of generating an antibody specific to an epitope of an HIV-Env polypeptide, comprising delivering to an animal or a human an effective amount of a suspension of virus-like particles comprising a chimeric HIV-Eny polypeptide, thereby inducing the formation of an antibody specific to an epitope of an HIV-1 eny polypeptide. | 08-05-2010 |
20100239617 | MODIFIED RSV F PROTEINS AND METHODS OF THEIR USE - The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection. | 09-23-2010 |
20100247574 | CHIMERIC NEWCASTLE DISEASE VIRUS VLPs - The present invention discloses and claims chimeric virus like particles (VLPs) that express and/or contains Newcastle disease matrix protein. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising chimeric VLPs of the inventions. The invention also includes methods of making and administrating chimeric VLPs to vertebrates, including methods of inducing immunity to infections. | 09-30-2010 |
20130039938 | HIGHLY EFFICIENT INFLUENZA MATRIX (M1) PROTEINS - This invention discloses a method of increasing production of virus-like particles comprising expressing an avian influenza matrix protein. The invention also comprises methods of making and using said VLPs. | 02-14-2013 |
20140294879 | MODIFIED RSV F PROTEINS AND METHODS OF THEIR USE - The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection. | 10-02-2014 |
Gale Smith, Darnestown, MD US
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20100035813 | RECOMBINANT E-SELECTIN MADE IN INSECT CELLS - The inventive features include recombinant mammalian E-selectin peptides, nucleic acids encoding said peptides, vectors and cells having these nucleic acids, and methods of making the peptides. Further inventive features include methods of treating diseases and conditions associated with inflammation using recombinant mammalian E-selectin peptides to induce mucosal tolerance to E-selectin. | 02-11-2010 |
Gale E. Smith, Darnestown, MD US
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20100159524 | APPARATUS AND METHODS FOR PRODUCING AND USING HIGH-DENSITY CELLS AND PRODUCTS THEREFROM - Disclosed and claimed is apparatus and methods for the growth of cells to high density, products therefrom and uses thereof. Also disclosed and claimed is the use of this method for the growth to high-density insect cells, such as the | 06-24-2010 |
Gary J. Smith, Woodbine, MD US
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20120290373 | APPARATUS AND METHOD FOR MARKETING-BASED DYNAMIC ATTRIBUTION - A computer implemented method and apparatus for determining marketing-based attribution that may be used for targeted and effective acquisition of customers when multiple marketing interactions are employed to target the consumers attention. The method and apparatus provide also provides a mechanism for appropriately rewarding the marketing partners in customer acquisition. | 11-15-2012 |
Gary P. Smith, Germantown, MD US
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20120208163 | COLLABORATIVE INSTRUCTIONAL METHOD AND SYSTEM - A system and method for comprehensive, fully or partially automated instructional plan creation, management, and tracking is provided. Variations of the system may include specialized computer systems, specialized applications, or web-based server-side solutions. Variations of the method may include generation of integrated or course-based instructional plans based on a relationship between standards and indicators of educational success and an academic schedule divided into schedule units. Instructional plans may be populated with learning and teaching resources from a content repository. Such population may be automated, customized, based on user settings, and otherwise configurable on a per-instructor basis. Instructors may also load content into the repository, associate content with one or more identifying parameters, and collaborate with each-other based on teaching style and resource choices. | 08-16-2012 |
Harold E. Smith, Bethesda, MD US
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20120064560 | FOLDING OF RECOMBINANT PROTEINS VIA CO-EXPRESSION OF ARCHAEAL CHAPERONES - The present invention relates to recombinant protein production, and more specifically, to methods for recovery of properly folder bioactive proteins by expressing chaperone genes from extremophilic Archaea, during recombinant protein synthesis in a host cell thereby significantly improving recovery of properly folded bioactive proteins. | 03-15-2012 |
Harry Smith, Baltimore, MD US
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20110021169 | NOISE REDUCTION SYSTEM AND METHOD - A noise reduction method is disclosed that uses numerical logic to estimate the value of the noise in a receive system and remove the noise. A surrogate probe value is selected and subtracted from an input signal and an iterative process selects a noise probe value for each iteration and the respective noise probe values are summed resulting in a noise estimate that is combined with the input signal. | 01-27-2011 |
Ian M. Smith, Baltimore, MD US
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20120142546 | HYPOMETHYLATED GENES IN CANCER - The present invention provides methods and kits for identifying a cell that exhibits or is predisposed to exhibiting unregulated growth by detecting hypomethylation of a gene or a regulatory region in at least one gene in the cell. Also provided are methods for diagnosis or prognosis of a proliferative disorder in a subject. Also provided are methods of ameliorating a cell proliferative disorder in a subject by administering to the subject an agent that methylates a hypomethylated gene or regulatory region thereof. In some aspects, the gene or regulatory region thereof is TKTL1, H19, MAGEA2, MAGEA3, MAGEA4, MAGEA11, GPR1 7, GRTN1, C19ORF28, MAGEA12, MAGEA1, MAGEA5, NY-ESO-1, MAGEA9, MAGEA6, MAGEB2, CT45-2, SBSN, G6PD, ZNF711, CrispL, KRT86, KIPV467, KRT81, CSPG5, PP1R14A, KISS1R, KIAA1937 protein, SOX30, DEAD, or KBGP. | 06-07-2012 |
Jacqueline Smith, Bowie, MD US
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20120294900 | Phosphorylated and Branched Dihydroxy-Pentane-Dione (DPD) Analogs as Quorum Sensing Inhibitors in Bacteria - Provided are compositions and methods for modulating quorum sensing in microbes. The compounds are AI-2 analogs and as such have structures similar to 4,5-dihydroxy-2,3-pentanedione that can act as agonists/antagonists of quorum sensing. The compounds are useful for modulating quorum sensing in bacteria and can be used in methods for prophylaxis or therapy of bacterial infections and for reduction of biofilms. | 11-22-2012 |
James T. Smith, Columbia, MD US
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20090078900 | Miniaturized Double Latching Solenoid Valve - A valve includes a generally elongate pintle; a spacer having a rounded surface that bears against the pintle; a bulbous tip fixed to the spacer; and a hollow, generally cylindrical collar fixed to the pintle, the collar enclosing the spacer and the tip and including an opening through which a portion of the tip extends, the opening in the collar and interior of the collar being of a size such that the tip floats therein. | 03-26-2009 |
Janine A. Smith, Potomac, MD US
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20100272777 | OCULAR THERAPEUTIC AGENT DELIVERY DEVICES AND METHDOS FOR MAKING AND USING SUCH DEVICES - Ocular implant devices ( | 10-28-2010 |
Jared Brian Smith, Rockville, MD US
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20090313047 | Brain Condition Assessment - Methods, systems, and apparatus, including medium-encoded computer program products, for creating an indication of brain condition include: receiving first information concerning a person, the first information indicating presence or absence of markers for an aspect of an assessment performed for the person, the aspect occurring at least twice at respective portions of the assessment; generating an indication of brain condition for the person by comparing the first information with second information concerning a group of people for whom the assessment has been performed, where the comparing includes checking a conditional probability of finding the marker present for the aspect of the assessment in one of the portions of the assessment when the marker is present for the aspect in another of the portions of the assessment; and outputting the indication of brain condition for the person. | 12-17-2009 |
Jason Robert Smith, Baltimore, MD US
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20110301935 | LOCATING PARALLEL WORD SEQUENCES IN ELECTRONIC DOCUMENTS - Systems and methods for automatically extracting parallel word sequences from comparable corpora are described. Electronic documents, such as web pages belonging to a collaborative online encyclopedia, are analyzed to locate parallel word sequences between electronic documents written in different languages. These parallel word sequences are then used to train a machine translation system that can translate text from one language to another. | 12-08-2011 |
Jeffrey S. Smith, Ellicott City, MD US
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20110055306 | OPTIMAL PADDING FOR THE TWO-DIMENSIONAL FAST FOURIER TRANSFORM - Padding or adding data to a data signal can increase the speed with which a signal processor can process the data. Methods are provided herein that can accurately predict the optimal pad size of a two dimensional array of data, which can be used to increase the processing speed of a signal processor by optimizing run-time for a two-dimensional (2-D) fast Fourier transform (FFT) operation. | 03-03-2011 |
Jeffrey S. Smith, Baltimore, MD US
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20140062732 | VECTORIZED REBINNING FOR FAST DATA DOWN-SAMPLING - A rebinning device includes a rebinning engine that transforms signal data from a first format to a second format with vectorized binning. Moreover, a data storage operably coupled to the rebinning engine stores the signal data in the second format. The rebinning device may optionally includes a capturing engine that captures the signal data in the first format and a rendering engine that renders the signal data in the second format. | 03-06-2014 |
Jeffrey Scott Smith, Baltimore, MD US
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20120013965 | METHOD FOR UTILIZING PROPERTIES OF THE SINC(X) FUNCTION FOR PHASE RETRIEVAL ON NYQUIST-UNDER-SAMPLED DATA - Disclosed herein are systems, methods, and non-transitory computer-readable storage media for simulating propagation of an electromagnetic field, performing phase retrieval, or sampling a band-limited function. A system practicing the method generates transformed data using a discrete Fourier transform which samples a band-limited function f(x) without interpolating or modifying received data associated with the function f(x), wherein an interval between repeated copies in a periodic extension of the function f(x) obtained from the discrete Fourier transform is associated with a sampling ratio Q, defined as a ratio of a sampling frequency to a band-limited frequency, and wherein Q is assigned a value between 1 and 2 such that substantially no aliasing occurs in the transformed data, and retrieves a phase in the received data based on the transformed data, wherein the phase is used as feedback to an optical system. | 01-19-2012 |
Jessica L. Smith, Frederick, MD US
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20100261178 | High Throughput Assays for Inhibitors and Activators of PAQR Receptors - The subject invention provides methods of screening compounds or ligands that interact with human and/or non-human PAQR receptors or fungal osmotin receptors. These methods utilize a colorimetric assay to ascertain whether a compound binds to and activates a PAQR receptor or the osmotin receptor. | 10-14-2010 |
Joseph T. Smith, Columbia, MD US
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20090059675 | Radiation hardened multi-bit sonos non-volatile memory - In one aspect, a radiation hardened transistor includes a buried source, buried drain and a poly-silicon gate separated from the buried source and the buried drain by a buried oxide. A recessed P+ implant or a blanket P+ implant is disposed in a substrate. A portion of the recessed P+ implant or a portion of the blanket P+ implant is disposed beneath outer edges of the poly-silicon gate, in a channel separating the buried source and the buried drain. | 03-05-2009 |
20090194870 | Method and Apparatus for Solid State Cooling System - The disclosure relates to a Point Cooler based on a combination of principles, including large area, low current density PN junction cooling, and electron emission from heavily doped shallowly-depleted P tips. Using Junction Cooling rather than thermoelectric cooling enables an all silicon device to be made that favorably competes with the commercial thermoelectric cooling systems. Theoretical values of T | 08-06-2009 |
20090283824 | COOL IMPACT-IONIZATION TRANSISTOR AND METHOD FOR MAKING SAME - In one embodiment, the disclosure relates to a low-power semiconductor switching device, having a substrate supporting thereon a semiconductor body; a source electrode coupled to the semiconductor body at a source interface region; a drain electrode coupled to the semiconductor body at a drain interface region; a gate oxide film formed over a region of the semiconductor body, the gate oxide film interfacing between a gate electrode and the semiconductor body; wherein at least one of the source interface region or the drain interface region defines a sharp junction into the semiconductor body. | 11-19-2009 |
20090320913 | LATERAL ULTRA-HIGH EFFICIENCY SOLAR CELL - A high-efficiency lateral multi-junction solar cell (C) includes ultra-low profile planar spectral band splitting micro-optics having a shortpass filter ( | 12-31-2009 |
20110249160 | INDIUM TIN OXIDE GATE CHARGE COUPLED DEVICE - An Indium Tin Oxide (ITO) gate charge coupled device (CCD) is provided. The CCD device comprises a CCD structure having a substrate layer, an oxide layer over the substrate layer, a nitride layer over the oxide layer and a plurality of parallel ITO gates extending over the nitride layer. The CCD device further comprises a plurality of substantially similarly sized channel stop regions in the substrate layer that extend transversely relative to the ITO gates, such that a given pair of channel stop regions defining a pixel column of the CCD structure. The CCD device also comprises a plurality of vent openings that extend through the nitride layer along the plurality of substantially similarly sized channel stop regions to allow for penetration of hydrogen to at least one of the oxide layer and the substrate layer. | 10-13-2011 |
Joseph Terence Smith, Columbia, MD US
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20100108138 | Photovoltaic silicon solar cells - A photovoltaic semiconductor solar cell with a backside semiconductor-oxide-nitride-oxide nonvolatile charge storage structure (referred to as a “PHONOS solar cell”) is disclosed. The PHONOS solar cell includes a semiconductor surface region, a semiconductor bulk region, and a backside structure that includes the SONO nonvolatile charge storage structure and a backside contact. The backside SONO nonvolatile charge storage structure greatly improves solar cell efficiency gains by eliminating “backside” losses, i.e., losses due to the recombination of photo-generated minority charge carriers created by the incident sunlight. The PHONOS solar cell is a highly efficient, ultra-thin, semiconductor solar cell that can be manufactured at low cost. | 05-06-2010 |
20120115292 | METHOD FOR INTEGRATING SONOS NON-VOLATILE MEMORY INTO A STANDARD CMOS FOUNDRY PROCESS FLOW - An embodiment of a method is disclosed to integrate silicon oxide nitride oxide silicon (SONOS) non-volatile memory (NVM) into a conventional complementary metal oxide semiconductor (CMOS) semiconductor foundry process flow. An embodiment of the method only adds a few additional steps to a standard CMOS foundry process flow and makes minor changes to the rest of the baseline CMOS foundry process flow to form a new process module that includes both CMOS devices and an embedded SONOS NVM. | 05-10-2012 |
J. Todd Wesley Smith, Arnold, MD US
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20080228614 | Consumer-driven system and method for promoting philanthropic giving/lending and social activism based on customer purchases - A consumer-driven system and method for promoting philanthropic giving/lending and social activism based on customer purchases. The system and method optimizes the choices on the part of the Customer in the selection of one or more Funding Options and allocation of Funding Points among one or more selected Funding Options. Feedback information concerning the progress of the funds permits the Customer to evaluate the effectiveness or success of the Funding Option; target feedback content to the Customers that have provided funds via the sponsoring entity; and/or prompt the donor/lendor for additional involvement or action concerning the Funding Option to promote continued engagement on the part of the Customer. | 09-18-2008 |
Kirby D. Smith, Baltimore, MD US
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20130123203 | METHODS AND COMPOSITIONS FOR TREATMENT OF AUTISM - Disclosed herein are methods and compositions for treating autism. Disclosed herein are methods and compositions for treating an autism spectrum disorder. | 05-16-2013 |
20150051288 | Methods and Compositions for Treatment of Autism - Disclosed herein are methods and compositions for treating autism. Disclosed herein are methods and compositions for treating an autism spectrum disorder. | 02-19-2015 |
Kirsten Smith, Silver Spring, MD US
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20110092488 | Quninoline Methanol Compounds for the Treatment and Prevention of Parasitic Infections - Malaria is responsible for 1-2 million deaths and 300-500 million clinical cases annually and is an ever present problem for the military, tourists and business travelers. Mefloquine is known and used for malaria prophylaxis. However it is associated with neurological effects. The present invention is directed to providing new and novel quinoline analogs that are less neurotoxic than mefloquine without compromising efficacy. The present invention is also directed to the prevention and treatment of other microbial, parasitic, protozoan, bacterial and fungal diseases. | 04-21-2011 |
Kyle R. Smith, Gaithersburg, MD US
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20090276105 | ROBOTIC VEHICLE REMOTE CONTROL SYSTEM HAVING A VIRTUAL OPERATOR ENVIRONMENT - A control system for a remotely operated vehicle is disclosed. The control system includes a sensor tracking system configured to sense the remotely operated vehicle. The control system is coupled to the sensor tracking system and is configured to remotely control the remotely operated vehicle. The control system includes a synthetic view generator configured to construct a virtual model of the remotely operated vehicle and its surrounding environment based upon an input from the sensor tracking system. The control system also includes a graphical user interface configured to display a synthetic view of the virtual model. In addition, the control system includes a synthetic viewer control configured to manipulate an orientation of the synthetic view. | 11-05-2009 |
Leonard A. Smith, Clarksburg, MD US
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20100273211 | Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy - Botulinum neurotoxins, the most potent of all toxins, induce lethal neuromuscular paralysis by inhibiting exocytosis at the neuromuscular junction. The light chains (LC) of these dichain neurotoxins are a new class of zinc-endopeptidases that specifically cleave the synaptosomal proteins, SNAP-25, VAMP, or syntaxin at discrete sites. The present invention relates to the construction, expression, purification, and use of synthetic or recombinant botulinum neurotoxin genes. For example, a synthetic gene for the LC of the botulinum neurotoxin serotype A (BoNT/A) was constructed and overexpressed in | 10-28-2010 |
20130345398 | Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy - The present invention relates to the construction, expression, and purification of synthetic or recombinant light chain (LC) | 12-26-2013 |
Leonard A. Smith, Fort Detrick, MD US
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20110294848 | SMALL MOLECULE INHIBITORS OF BOTULINUM NEUROTOXINS - The invention provides potent quinolinol-based BoNT/A small-molecule inhibitors of botulinum neurotoxins, in particular of | 12-01-2011 |
Leslie N. Smith, Baltimore, MD US
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20130163882 | METHOD OF ESTIMATING BLUR KERNEL FROM EDGE PROFILES IN A BLURRY IMAGE - A method of deblurring a two-dimensional, blurred image. An edge within the blurred image is detected, and an edge profile of the blurred image is extracted. A length of the edge profile is determined, and a blur kernel size is estimated based thereon. A preliminary linearity metric is obtained iteratively until a best linearity metric, a best quantile function, and a best quantile function output are determined. A slope of the best quantile function output is determined, and a blurring parameter is determined based thereon. A blur kernel is estimated based on the blurring parameter and the blur kernel size. A sharp image is resolved using the blur kernel. | 06-27-2013 |
Marcus Smith, Temple Hills, MD US
Patent application number | Description | Published |
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20120212336 | System for Enhancing Perception of a Motor Vehicle's Mark Emblem - A system is provided for causing audible sounds, and/or visible actions, and/or an electronic visual image, and/or motion to occur by, or in relation to, a vehicle's mark emblem. The system may cause such actions to be initiated manually or automatically as a result of vehicle operation or operator action. Controls may be provided to prevent the audible sound, visible action, visual image, or motion to occur if the vehicle speed is above a selected speed limit. In addition, when operated from a position remote from the vehicle, the audible sound associated with the mark emblem may be adjusted to a volume that will prevent persons from becoming startled when they are in proximity to the vehicle. | 08-23-2012 |
Mark Frederick Smith, Catonsville, MD US
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20100316275 | Method for image reconstruction of moving radionuclide source distribution - A method for image reconstruction of moving radionuclide distributions. Its particular embodiment is for single photon emission computed tomography (SPECT) imaging of awake animals, though its techniques are general enough to be applied to other moving radionuclide distributions as well. The invention eliminates motion and blurring artifacts for image reconstructions of moving source distributions. This opens new avenues in the area of small animal brain imaging with radiotracers, which can now be performed without the perturbing influences of anesthesia or physical restraint on the biological system. | 12-16-2010 |
Mitchell David Smith, Bel Air, MD US
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20100124654 | CONSTANT PRESSURE INFUSION PROCESS FOR RESIN TRANSFER MOLDING - Methods and apparatuses for making PMC's and composites include an infusing step wherein the resin reservoir and the preform are maintained under substantially the same vacuum pressure during the infusing step or the associated structure associated with the maintenance. Substantially the same vacuum pressure may be accomplished using a collapsible resin reservoir that is enclosed within or external to the vacuum bagging assembly of the fiber preform. This method results in a maximum achievable vacuum compaction pressure and simplified resin infusion process. This process may be used to manufacture prepregs and aerospace grade fiber reinforced resin composites, also disclosed herein, that have fiber volume, void content and laminate quality that meets or exceeds those made using an autoclave. | 05-20-2010 |
Paul D. Smith, Annapolis, MD US
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20090201467 | FUNDUS PHOTO-STIMULATION SYSTEM AND METHOD - An eye examination device has a fundus observation system and an optical stimulation system. The optical stimulation system has an optical targeting subsystem and an optical stimulation subsystem, wherein the optical stimulation system is structured to be used to provide light stimulation to a portion of a fundus of an eye targeted by the optical targeting subsystem in conjunction with observations made with the fundus observation system. | 08-13-2009 |
Paul Reed Smith, Annapolis, MD US
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20120041994 | PRECISION MEASUREMENT OF WAVEFORMS - A machine-implemented method for computerized digital signal processing including obtaining a digital signal from data storage or from conversion of an analog signal, and determining, from the digital signal, one or more measuring matrices. Each measuring matrix has a plurality of cells, and each cell has an amplitude corresponding to the signal energy in a frequency bin for a time slice. Cells in each measuring matrix having maximum amplitudes along a time slice and/or frequency bin are identified as maximum cells. Maxima that coincide in time and frequency are identified and a correlated maxima matrix, called a “Precision Measuring Matrix” is constructed showing the coinciding maxima and the adjacent marked maxima are linked into partial chains. | 02-16-2012 |
20130046805 | Precision Measurement of Waveforms Using Deconvolution and Windowing - The invention consists of new ways of constructing a Measuring Matrices (MMs) including time deconvolution of Digital Fourier Transforms DFTs. Also, windowing functions specifically designed to facilitate time deconvolution may be used, and/or the DFTs may be performed in specific non-periodic ways to reduce artifacts and further facilitate deconvolution. These deconvolved DFTs may be used alone or correlated with other DFTs to produce a MM. | 02-21-2013 |
20130191062 | Domain Identification and Separation for Precision Measurement of Waveforms - A machine-implemented method for computerized digital signal processing obtains a digital signal from data storage or from conversion of an analog signal and determines, from the digital signal, Measuring Matrices (MM). Each measuring matrix has a plurality of cells, each cell having an amplitude corresponding to the signal energy in a frequency bin for a time slice. Cells in each measuring matrix having maximum amplitudes within a time slice are identified as maximum cells. Maxima that coincide in time and frequency are identified and a correlated maxima matrix (PMM) is constructed showing the coinciding maxima and the adjacent marked maxima are linked into partial chains. If only one MM is constructed, multiple types of maxima are identified to generate the (PMM). The partial chains are isolated by parameters for a single domain or multiple domains to identify partial chains and possible separation of complex compound waveforms in the digital signal. | 07-25-2013 |
20130251223 | Scoring and Adjusting Pixels Based on Neighborhood Relationships for Revealing Data in Images - A machine/computer implemented system, method, and computer program product for scored pixel intensity value adjustment of a digital image is disclosed. The system is configured to obtain a digital image from data storage and perform pixel-by-pixel comparisons to generate per pixel scores. The types of comparisons include discovering minima and maxima per pixel scores by comparing to neighboring non-adjacent pixel pairs, delta pair scores by comparing to neighboring pixels, and multiple vector score types by comparing to vectors made up of individual pixels. This new information is applied to adjust each pixel's value. The system is further configured to generate a collection of such scores for a plurality of pixels in a digital image and to generate a multi-dimensional scored pixel adjusted image. The scored pixel adjustment yields a new digital image, wherein the value of a given pixel is adjusted based on one or more of the score types. | 09-26-2013 |
20140351302 | Precision Measurement of Waveforms - A machine-implemented method for computerized digital signal processing including obtaining a digital signal from data storage or from conversion of an analog signal, and determining, from the digital signal, one or more measuring matrices. Each measuring matrix has a plurality of cells, and each cell has an amplitude corresponding to the signal energy in a frequency bin for a time slice. Cells in each measuring matrix having maximum amplitudes along a time slice and/or frequency bin are identified as maximum cells. Maxima that coincide in time and frequency are identified and a correlated maxima matrix, called a “Precision Measuring Matrix” is constructed showing the coinciding maxima and the adjacent marked maxima are linked into partial chains. | 11-27-2014 |
Philip Smith, Ellicott City, MD US
Patent application number | Description | Published |
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20090059675 | Radiation hardened multi-bit sonos non-volatile memory - In one aspect, a radiation hardened transistor includes a buried source, buried drain and a poly-silicon gate separated from the buried source and the buried drain by a buried oxide. A recessed P+ implant or a blanket P+ implant is disposed in a substrate. A portion of the recessed P+ implant or a portion of the blanket P+ implant is disposed beneath outer edges of the poly-silicon gate, in a channel separating the buried source and the buried drain. | 03-05-2009 |
Philip C. Smith, Ellicott City, MD US
Patent application number | Description | Published |
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20100197063 | Method of Manufacturing a Micro-Electrical-Mechanical System with Thermally Isolated Active Elements - A method of manufacturing a micro-electrical-mechanical system with thermally isolated active elements. Such a system may embody a bolometer, which is well suited for detecting electromagnetic radiation between 90 GHz and 30 THz while operating at room temperature. The method also discloses a generalized process for manufacturing circuitry incorporating active and passive micro-electrical-mechanical systems in a silicon wafer. | 08-05-2010 |
Rachel R. Smith, Baltimore, MD US
Patent application number | Description | Published |
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20080267921 | Cardiac Stem Cells - Human cardiac stem cells can be isolated from endomyocardial biopsies. Such cells mediate cardiac regeneration and improve heart function in a mouse infarct model. The cells can be used for autologous, allogeneic, syngeneic, or xenogeneic therapeutic applications in patients. The stem cells can be genetically modified to enhance their therapeutic activity. | 10-30-2008 |
20100061966 | Cardiac Stem Cells - Human cardiac stem cells can be isolated from endomyocardial biopsies. Such cells mediate cardiac regeneration and improve heart function in a mouse infarct model. The cells can be used for autologous, allogeneic, syngeneic, or xenogeneic therapeutic applications in patients. The stem cells can be genetically modified to enhance their therapeutic activity. | 03-11-2010 |
20100068811 | Cardiac Stem Cells - Human cardiac stem cells can be isolated from endomyocardial biopsies. Such cells mediate cardiac regeneration and improve heart function in a mouse infarct model. The cells can be used for autologous, allogeneic, syngeneic, or xenogeneic therapeutic applications in patients. The stem cells can be genetically modified to enhance their therapeutic activity. | 03-18-2010 |
Rejane M. Smith, Elkton, MD US
Patent application number | Description | Published |
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20110086345 | ISOLATION AND USE OF RYANODINE RECEPTORS - The genes encoding ryanodine receptor homologs have been characterized from multiple insect families including lepidopteran tobacco budworm ( | 04-14-2011 |
20110269144 | RYANODINE RECEPTOR POLYPEPTIDES - The genes encoding ryanodine receptor homologs have been characterized from multiple insect families including lepidopteran tobacco budworm ( | 11-03-2011 |
20120276554 | ISOLATION AND USE OF RYANODINE RECEPTORS - The genes encoding ryanodine receptor homologs have been characterized from multiple insect families. The genes and their corresponding polypeptides have a number of uses including but not limited to the development of screens to identify insecticidally active compounds. Methods are outlined for overcoming toxic effects of expressing recombinant proteins in host cells. | 11-01-2012 |
Robert Benjamin Smith, White Hall, MD US
Patent application number | Description | Published |
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20120018250 | Safety strap assembly for tree climbers - A safety strap assembly is used by a climber for ascending, remaining secured at height and descending from a tree or pole. The safety strap assembly includes a tubular strap; an elastic strap; a stiffening member; a string; a coupling; and a finger-pull. Optionally, an oval chain-link is included. The tubular strap fits around a tree. One end of the tubular strap is connected to an elastic strap. The other end is attachable to the climber. The stiffening member fits within the tubular member. A string extending from two holes in the tubular strap permit the stiffening member to be shifted. The coupling at the free end of the elastic strap connects to the tubular strap in a removable slidable engagement. The finger-pull at that connection breaks away if the climber falls enabling the tubular strap to engage the tree and prevent a fall to the ground. | 01-26-2012 |
Rodger Smith, Jefferson, MD US
Patent application number | Description | Published |
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20090280116 | HUMANIZED ANTIBODIES AGAINST TL1A - Disclosed are humanized antibodies that bind specifically to the receptor TNF superfamily member 15 (TNFSF15), also known as TL1A. Methods of making and using the anti-TL1A antibodies are also described. The humanized antibodies may be antagonists and may used to treat or diagnose conditions associated with TL1A function. | 11-12-2009 |
20100047238 | HUMANIZED ANTIBODIES AGAINST - Disclosed are humanized antibodies that bind specifically to the receptor CXCR3. The humanized antibodies may be antagonists and may be used to treat or diagnose conditions associated with CXCR3 function. | 02-25-2010 |
20120100074 | HUMANIZED ANTIBODIES AGAINST LIGHT AND USES THEREOF - The present invention is directed to antigen-binding polypeptides, or variants or derivatives thereof which specifically bind the LIGHT polypeptide. The invention is also directed to methods of making and using such antibodies specifically in the treatment or diagnosis of immune, inflammatory and malignant diseases or conditions (e.g. inflammatory bowel disease; Crohn's disease, ulcerative colitis, multiple sclerosis, rheumatoid arthritis and transplantation). | 04-26-2012 |
20130274447 | HUMANIZED ANTIBODIES AGAINST CXCR3 - Disclosed are humanized antibodies that bind specifically to the receptor CXCR3. The humanized antibodies may be antagonists and may be used to treat or diagnose conditions associated with CXCR3 function. | 10-17-2013 |
20130323240 | HUMANIZED ANTIBODIES AGAINST LIGHT AND USES THEREOF - The present invention is directed to antigen-binding polypeptides, or variants or derivatives thereof which specifically bind the LIGHT polypeptide. The invention is also directed to methods of making and using such antibodies specifically in the treatment or diagnosis of immune, inflammatory and malignant diseases or conditions (e.g. inflammatory bowel disease; Crohn's disease, ulcerative colitis, multiple sclerosis, rheumatoid arthritis and transplantation). | 12-05-2013 |
20140315250 | HUMANIZED ANTIBODIES AGAINST TL1A - Disclosed are humanized antibodies that bind specifically to TNF superfamily member 15 (TNFSF15), also known as TL1A. Methods of making and using the anti-TL1A antibodies are also described. The humanized antibodies may be antagonists and may used to treat or diagnose conditions associated with TL1A function. | 10-23-2014 |
Rodger Smith, Rockville, MD US
Patent application number | Description | Published |
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20120308480 | HUMANIZED ANTIBODIES AGAINST TL1A - Disclosed are humanized antibodies that bind specifically to TNF superfamily member 15 (TNFSF15), also known as TL1A. Methods of making and using the anti-TL1A antibodies are also described. The humanized antibodies may be antagonists and may used to treat or diagnose conditions associated with TL1A function. | 12-06-2012 |
Rodger G. Smith, Jefferson, MD US
Patent application number | Description | Published |
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20090029914 | Albumin Fusion Proteins - The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention. | 01-29-2009 |
Ronald Smith, Ellicott City, MD US
Patent application number | Description | Published |
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20100226494 | SYSTEM AND METHOD FOR PAYLOAD ENCODING AND DECODING - Systems, methods and apparatuses are disclosed for protecting encoded media data. A minimum set of information needed to encode a single message for an encoded audio signal is loaded separately from the media data into an encoder. A media license file is generated to protect the encoded data, where the underlying information relevant to the media data may be hidden through encryption or other means in order to foster security. The algorithm(s) for encoding may be provided using a shared library, combined with an encoding payload that provides the minimum information set required to form the single message. A partial decoder may apply pattern matching information in the encoded payload in order to confirm that the encoding is actually present and is proper. Accordingly, the payload must be successfully decoded and verified before the underlying data may be decoded. | 09-09-2010 |
Ronald H. Smith, Rockville, MD US
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20130139717 | Global rapid transit infrastructure using linear induction drive - Transportation infrastructure comprises linear induction drives wherein a roadway surface is induced to simultaneously exert forward, lateral, levitation and three axis angular alignment forces on a vehicle and wherein a vehicle is capable of inducing roadway surface currents that produce said forces in said roadway surface. Comprehensive system sustains continuous traffic flow from the point of entering the infrastructure to the moment of disembarking in a parking facility. Transportation infrastructure comprises integration of air and space travel with substantially reduced cost and transit time. | 06-06-2013 |
Russell S. Smith, Boyds, MD US
Patent application number | Description | Published |
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20110284777 | Wireless Fluid Shut-Off Valve - A low-cost safety valve for gas lines and similar supply lines that can be remotely activated via a secure wireless link employing a low leakage sealing mechanism that is compatible with low energy actuators to for extended battery life. A miniaturized controller and wireless electronics assembly provides the control mechanism for actuating the valve, as well as reporting data regarding the valve status to wireless interrogators or external networks via an ad hoc wireless network. A variety of simple magnetic valve operating mechanisms can be implemented with the miniaturized electronic control circuits and the valve body. Such control actuation mechanisms enable automatic resetting or manual resetting valves. The gas line shut off valve can provide important safety benefits at an affordable price. | 11-24-2011 |
20130113631 | SYSTEMS AND METHODS FOR GENERATING POWER THROUGH THE FLOW OF WATER - A remote water meter monitoring system is provided. A mesh network-type transceiver unit is coupled to a water meter housing having a water counting mechanism inside to transmit water consumption information as well as other sensor information, such as backflow detection, water pressure, and water metrics (e.g., residual chlorine and temperature) to a central server system via a bridge device and a corresponding mesh network. Mechanical energy from the water flowing through the water meter housing is converted to electrical energy via an energy conversion unit. An electrically powered shut off valve is remote addressable via the transceiver unit. | 05-09-2013 |
20140061519 | Wireless Fluid Shut-Off Valve - A low-cost safety valve for gas lines and similar supply lines that can be remotely activated via a secure wireless link employing a low leakage sealing mechanism that is compatible with low energy actuators to for extended battery life. A miniaturized controller and wireless electronics assembly provides the control mechanism for actuating the valve, as well as reporting data regarding the valve status to wireless interrogators or external networks via an ad hoc wireless network. A variety of simple magnetic valve operating mechanisms can be implemented with the miniaturized electronic control circuits and the valve body. Such control actuation mechanisms enable automatic resetting or manual resetting valves. The gas line shut off valve can provide important safety benefits at an affordable price. | 03-06-2014 |
20140110613 | Wireless Fluid Shut-Off Valve - A low-cost safety valve for gas lines and similar supply lines that can be remotely activated via a secure wireless link employing a low leakage sealing mechanism that is compatible with low energy actuators to for extended battery life. A miniaturized controller and wireless electronics assembly provides the control mechanism for actuating the valve, as well as reporting data regarding the valve status to wireless interrogators or external networks via an ad hoc wireless network. A variety of simple magnetic valve operating mechanisms can be implemented with the miniaturized electronic control circuits and the valve body. Such control actuation mechanisms enable automatic resetting or manual resetting valves. The gas line shut off valve can provide important safety benefits at an affordable price. An RFID transceiver may be included to enable low-power operation and communications using RFID technologies as well as an automatic antenna tuning capability to maximize radio range. | 04-24-2014 |
Seth Smith, Perry Hall, MD US
Patent application number | Description | Published |
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20080199061 | Quantitative Single Image-Based Magnetization Transfer Weighted Imaging Using an Inter-Subject Normalization Reference Within the Image - Disclosed is a system and method for generating quantitative imagery of demyelination in the spinal cord. The method includes acquiring a magnetization transfer weighted (MTw) MR image of the spinal column, identifying a reference region of interest within the image corresponding to cerebrospinal fluid (CSF), averaging the signal intensity corresponding to the reference region of interest, and computing a ratio, on a voxel-by-voxel basis, of the signal intensity of each voxel by the averaged reference signal intensity. In doing so, normalized MTw images are obtained such that detrimental artifacts such as motion-induced errors, coil loading, and RF coil sensitivity variations are obviated. | 08-21-2008 |
20100166284 | QUANTITATIVE SINGLE IMAGE-BASED MAGNETIZATION TRANSFER WEIGHTED IMAGING USING AN INTER-SUBJECT NORMALIZATION REFERENCE WITHIN THE IMAGE - Disclosed is a system and method for generating quantitative imagery of demyelination in the spinal cord. The method includes acquiring a magnetization transfer weighted (MTw) MR image of the spinal column, identifying a reference region of interest within the image corresponding to cerebrospinal fluid (CSF), averaging the signal intensity corresponding to the reference region of interest, and computing a ratio, on a voxel-by-voxel basis, of the signal intensity of each voxel by the averaged reference signal intensity. In doing so, normalized MTw images are obtained such that detrimental artifacts such as motion-induced errors, coil loading, and RF coil sensitivity variations are obviated. | 07-01-2010 |
Theodore A.g. Smith, Ijamsville, MD US
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20090312278 | TREATMENT OF CANCERS OF THE BLOOD USING SELECTED GLYCOMIMETIC COMPOUNDS - Methods and medicaments therefor are provided for the treatment of cancers of the blood or a complication therewith in an individual. More specifically, the use of particular glycomimetics for the treatment is described. Methods and medicaments therefor are also provided without regard to cancer type for reducing in an individual the myeloablative bone marrow toxicities of chemotherapy. | 12-17-2009 |
Thomas Bobby Smith, Germantown, MD US
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20130237341 | PUTTING TRAINING DEVICE - A golf club device for improving one's golf abilities is disclosed. The device includes a head, and a shaft where the head is rotatably connected to at least an upper portion of the shaft. Rotation is achieved with an angular rotation mechanism. The angular rotation mechanism may include a variable resistance feature. The angular rotation mechanism may be positioned in or on the head, or it may be positioned in the shaft. One or more visual alignment indicators may also be employed. | 09-12-2013 |
Wanli W. Smith, Bel Air, MD US
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20100175140 | Leucine-rich repeat kinase (LRRK2) drosophila model for parkinson's disease: wildtype1 (WT1) and G2019S mutant flies - Mutations in the leucine-rich repeat kinase (LRRK2) gene cause late-onset autosomal dominant Parkinson's disease (PD) with pleiomorphic pathology. Previously, we and others found that expression of mutant LRRK2 causes neuronal degeneration in cell culture. Here we used the GAL4/UAS system to generate transgenic | 07-08-2010 |