Sly
Chad Sly, West Jordan, UT US
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20100250707 | ELECTRONIC CONCIERGE - Various embodiments of the invention provide a method of enhancing a user's stay at a facility. The method may comprise aggregating information specific to the user together with other information in order to create recommendation information. The method may further comprise providing an option to the user based upon the recommendation information and associated facility information. The method may further comprise using a selection made by the user in order to provide an option to a second user. Further embodiments of the invention provide an electronic concierge system that comprises a server configured to communicate server information to a display on at least one user terminal. The electronic concierge system may be configured to receive a user request from a user terminal and transmit information to the user terminal in response to the request. The user terminal information may be configured to be based at least in part on aggregated user information. Still other embodiments of the invention comprise a computer-readable medium having stored thereon a plurality of instructions, the plurality of instructions comprising instructions to accomplish the various methods disclosed herein. | 09-30-2010 |
George Sly US
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20110277852 | Automatic Rain Barrel - An automatic rain barrel is disclosed, providing the ability to easily use a mix of rainwater and water from another source for tasks such as watering landscaping. | 11-17-2011 |
Joseph Sly, San Jose, CA US
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20110243848 | STAR POLYMERS, METHODS OF PREPARATION THEREOF, AND USES THEREOF - A composition of matter comprising an amphiphilic star polymer, the star polymer comprising a crosslinked microgel core and 6 or more independent polymer arms covalently linked to the core, the 6 or more arms each comprising a hydrophilic polymer chain segment and a hydrophobic polymer chain segment; wherein each individual metal selected from the group consisting of beryllium, magnesium, calcium, strontium, barium, radium, aluminum, gallium, indium, thallium, germanium, tin, lead, arsenic, antimony, bismuth, tellurium, polonium, and metals of Groups 3 to 12 of the Periodic Table has a concentration in the star polymer of greater than or equal to 0 parts per million and less than or equal to 100 parts per million. | 10-06-2011 |
20120237447 | STAR POLYMER NANOSHELLS AND METHODS OF PREPARATION THEREOF - A nanoshell is disclosed, comprising a star polymer occlusion complex comprising i) an amphiphilic unimolecular star polymer having a crosslinked core covalently linked to 6 or more independent polymer arms, and ii) a cargo material occluded in the star polymer; and a shell comprising an inorganic material in contact with a peripheral surface of the star polymer occlusion complex. | 09-20-2012 |
20140370064 | FILM-FORMING COMPOSITIONS OF SELF-CROSSLINKABLE NANOGEL STAR POLYMERS - A film-forming composition comprises a solvent and unimolecular nanoparticles of a self-crosslinkable nanogel star polymer. The nanogel star polymer comprises i) a crosslinked polymer core (nanogel core) and ii) 6 or more independent polymer arms covalently linked to the core by respective first end groups. A plurality of the arms comprise reactive groups for effecting crosslinking of the nanoparticles. An essentially solvent-free film layer comprising the nanoparticles self-crosslinks, optionally assisted by subjecting the film layer to a thermal treatment and/or a photochemical treatment. A surface treated article comprising the crosslinked film layer can effectively inhibit growth of and/or kill Gram-negative microbes, Gram-positive microbes, fungi, and/or yeasts. | 12-18-2014 |
Matthew F. Sly, Jamaica Plain, MA US
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20110072034 | PRIVACY-SENSITIVE COOPERATIVE LOCATION NAMING - A location database may be configured to store a set of subjective, arbitrary, and/or ephemeral names assigned to a location by various users. When a user of a device arrives at a particular location, the device may retrieve and present to the user the set of names assigned to the location. Moreover, the names may be associated with a privacy designation, which may permit an author of a location name to indicate whether the name of a location should be shared with the public or restricted to access by the user (or to a specified group of users, etc.) Other access criteria may also be specified, e.g., read-only access to a name for the public and read/write access to a particular group of users. Within the set of names of a location, particular names may be designated as authoritative, and may be presented to users with emphasis. | 03-24-2011 |
Matthew Fuller Sly, Jamaica Plain, MA US
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20120321275 | COMPANION TIMELINE WITH TIMELINE EVENTS - A time-shifted digital content item is played via a playback screen, and an updateable companion timeline associated with the time-shifted digital content item is accessed. The updateable companion timeline includes one or more timeline events, and each timeline event has a trigger time corresponding to a playback time in the time-shifted digital content item. Responsive to reaching a playback time that matches a trigger time of one of the one or more timeline events during playback of the time-shifted digital content item, the timeline event having that trigger time is rendered. | 12-20-2012 |
Pat Sly, Newburgh, IN US
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20110315686 | Refillable Product Dispenser System - A refillable product dispenser system for powdered infant formula includes a reusable container having an initial product bag received in the container. Refills for the reusable container are provided in similar refill product bags which may be of lesser volume than the initial product bag. The refill bags may be packaged in a refill outer package containing two or more refill bags. | 12-29-2011 |
Peter Sly, Western Australia AU
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20100003241 | Agents for treatment or prevention of an allergic disorder - The present invention relates to agents capable of treating or preventing an allergic disorder in an animal and a method of screening for these agents. In particular, the present invention relates to an isolated nucleic acid molecule comprising (a) an isolated nucleic acid molecule whose expression is modulated in a mammal suffering from or at elevated risk of developing an allergic condition, such that the level of expression of the nucleic acid differs from that in a mammal which is not suffering from or at elevated risk of developing the allergic condition, in which the nucleic acid comprises a sequence selected from the group consisting of sequences identified by probes 243610 at on human chromosome 9q21.13 at locus 138255, 1556097 at on human chromosome 15q25.2 and 242743 at on human chromosome 16p12.1 respectively, or (b) an isolated nucleic acid molecule which is the complement of the nucleic acid of (a), or (c) an isolated nucleic acid molecule which hybridizes under stringent conditions to the nucleic acid of (a) or (b). | 01-07-2010 |
Peter Sly, East Perth AU
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20090062672 | Method of measuring an acoustic impedance of a respiratory system and diagnosing a respiratory disease or disorder or monitoring treatment of same - The present invention provides a method of measuring an acoustic impedance of a respiratory system. The method comprises selecting a frequency range for an acoustic wave, directing the acoustic wave into the respiratory system and receiving an acoustic wave from the respiratory system. The method also comprises determining the acoustic impedance for a plurality of volumes or volume ranges of the respiratory system. Each volume, or the volumes within each volume range, is larger than RV or FRC and smaller than TLC whereby the determined acoustic impedances are specific for respective volumes or volume ranges. Further, the method includes determining a volume, or volume range, dependency of the acoustic impedance of the respiratory system and charaterising the respiratory system by analysing the dependency of the acoustic impedance on the volume or volume range. | 03-05-2009 |
20090156540 | METHOD FOR DIAGNOSING AND/OR PREDICTING THE DEVELOPMENT OF AN ALLERGIC DISORDER AND AGENTS FOR TREATING AND/OR PREVENTING SAME - The present invention relates to genes whose level of expression is different in allergic animals compared with non-allergic animals. In particular, the present invention relates to a method for predicting the development of an allergic disorder in a mammal by determining the gene expression pattern of a panel of specific sequences comprising CAMK2D and CDH1 within a nucleic acid pool that have been predetermined to either increase or decrease in response to allergy. | 06-18-2009 |
Peter Sly, East Perth Wa AU
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20080227089 | Method of Diagnosing and/or Predicting the Development of an Allergic Disorder - The present invention relates to methods for diagnosing an allergic disorder, predicting the development of an allergic disorder in an animal, monitoring the progress of therapy targeted at an allergic disorder, classification of the allergic disorder into one or more clinical/immunological phenotypes, and/or determining the potentional responsiveness of individual animals suffering from or at risk of an allergic disorder to particular forms of therapy. In particular, the present invention relates to a method of diagnosing and/or predicting the development of an allergic disorder in an animal, comprising the step of analysing a biological sample from the animal to determine the level of activation of one or more allergy-associated genes, in which the level of activation is diagnostic of the allergic disorder or predicative of the relative risk for the development of an allergic disorder in the animal. | 09-18-2008 |
Robert Sly, Kent, OH US
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20110210193 | DISC MILL ASSEMBLY FOR A PULVERIZING APPARATUS - This invention relates to the art of methods and apparatuses for grinding various materials into smaller particles; particularly, to those known in the art as pulverizing systems and devices. This invention provides methods and apparatuses for an improved disc mill assembly that utilizes a tapered flywheel and water jacket in conjunction with planar grinding disk cutting devices to create a tapered grinding channel. | 09-01-2011 |
20120193459 | IN-LINE COLOR MIXER - The method of producing a colored powder of a polymeric material includes the steps of selecting a feedstock of said polymeric material, pulverizing said polymeric material in a pulverizer to produce a powder, moving the powder directly from the pulverizer to a mixer; spraying a liquid formulation including a colorant into the powder within the mixer, and mixing the liquid formulation and powder. | 08-02-2012 |
20130270373 | METHODS FOR PULVERIZING MATERIALS - This invention relates to the art of methods and apparatuses for grinding various materials into smaller particles; particularly, to those known in the art as pulverizing systems and devices. This invention provides methods and apparatuses for an improved disc mill assembly that utilizes a tapered flywheel and water jacket in conjunction with planar grinding disk cutting devices to create a tapered grinding channel. | 10-17-2013 |
20150014453 | IN-LINE COLOR MIXER - The method of producing a colored powder of a polymeric material includes the steps of selecting a feedstock of said polymeric material, pulverizing said polymeric material in a pulverizer to produce a powder, moving the powder directly from the pulverizer to a mixer; spraying a liquid formulation including a colorant into the powder within the mixer, and mixing the liquid formulation and powder. | 01-15-2015 |
Ward Sly, Brooklyn Park, MN US
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20150109193 | USE OF HUMAN INPUT RECOGNITION TO PREVENT CONTAMINATION - Embodiments of a system and method for processing and recognizing non-contact types of human input to prevent contamination are generally described herein. In example embodiments, human input is captured, recognized, and used to provide active input for control or data entry into a user interface. The human input may be provided in variety of forms detectable by recognition techniques such as speech recognition, gesture recognition, identification recognition, and facial recognition. In one example, the human input recognition techniques are used in connection with a device cleaning workflow used to obtain data and human input during cleaning procedures while minimizing cross-contamination between the contaminated device or person and other objects or persons. In another example, the human input recognition techniques are used in connection with a device tracking workflow used to obtain data and human input while tracking interactions with and locations of the contaminated or uncontaminated device. | 04-23-2015 |
William Sly, Saint Louis, MO US
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20110250187 | COMPOSITIONS AND METHODS FOR TREATING HYPOPHOSPHATASIA - The present invention provides compositions and methods for use in enzyme replacement therapy. The inventors disclose a method of producing membrane bound enzymes in an active soluble form by eliminating the glycosylphosphatidylinositol (GPI) membrane anchor. In particular the inventors disclose a soluble active form of the membrane bound enzyme TNSALP which they produced by deleting the GPI anchor single peptide sequence. They have further shown that this composition is useful for treatment of hypophosphatasia. The inventors also disclose oligo acid amino acid variants thereof which specifically target bone tissue. | 10-13-2011 |
20140377246 | ENZYME REPLACEMENT THERAPY FOR TREATING MPS VII RELATED BONE LESIONS USING A CHEMICALLY MODIFIED ENZYME - The invention relates to a method of treating mucopolysaccharidoses using enzyme replacement therapy with chemically modified lysosomal enzymes. More specifically the method relates to administering chemically modified lysosomal enzymes intraperitoneal injection. In addition, the invention relates to treating type VII mucopolysaccharidoses or mucopolysaccharidoses type VII related bone lesions with a chemical modified β-glucuronidase, wherein the modified β-glucuronidase may be administered 5 weeks after birth, and or may be administered intraperitoneally. | 12-25-2014 |
William S. Sly, Saint Louis, MO US
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20090238814 | COMPOSITIONS AND METHODS FOR TREATING HYPOPHOSPHATASIA - The present invention provides compositions and methods for use in enzyme replacement therapy. The inventors disclose a method of producing membrane bound enzymes in an active soluble form by eliminating the glycosylphosphatidylinositol (GPI) membrane anchor. In particular the inventors disclose a soluble active form of the membrane bound enzyme TNSALP which they produced by deleting the GPI anchor single peptide sequence. They have further shown that this composition is useful for treatment of hypophosphatasia. The inventors also disclose oligo acid amino acid variants thereof which specifically target bone tissue. | 09-24-2009 |
William S. Sly, St. Louis, MO US
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20090041741 | MODIFIED ENZYME AND TREATMENT METHOD - There is disclosed an isolated, modified recombinant β-glucuronidase wherein the modification is having its carbohydrate moeties chemically modified so as to reduce its activity with respect to mannose and mannose 6-phosphate cellular delivery system while retaining enzymatic activity Also disclosed are methods for the treatment of lysosomal storage disease in mammals wherein the mammal is administered a therapeutically effective amount of isolated, modified recombinant β-glucuronidase whereby said storage diseased is relieved in the brain and visceral organs of the mammal. Also disclosed are other lysosomal enzymes within the scope of the invention. | 02-12-2009 |
20100075906 | Targeted Therapeutic Proteins - Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic agent and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic upon internalization of the receptor. Nucleic acids, cells, and methods relating to the practice of the invention are also provided. | 03-25-2010 |
20100158889 | ENHANCING THE EFFECT OF THERAPEUTIC PROTEINS ON THE CENTRAL NERVOUS SYSTEM - The present invention provides a polypeptide therapeutic agent, useful in enzyme replacement therapy, with increased therapeutic benefits for the central nervous system. The invention provides a method of enhancing the effect of a polypeptide or protein on the central nervous system by the attachment of a short acidic amino acid sequence. Specifically the inventors disclose the attachment of a 4-15 acidic amino acid sequence to human β-glucuronidase by construction of a fusion protein. This molecule is useful in the treatment of type VII mucopolysaccharidosis when administered to a patient. | 06-24-2010 |
20110300143 | PRENATAL ENZYME REPLACEMENT THERAPY - The invention contemplates transplacental enzyme replacement therapy (ERT) for deficiency of a polypeptide such as a tissue-nonspecific alkaline phosphatase (TNSALP) by administering a before-described pharmaceutical composition to a pregnant animal whose fetus or embryo is in need of such therapy. The fusion protein of such a composition comprises a water-soluble TNSALP portion, e.g., C-terminus-truncated TNSALP peptide-bonded to an IgG1 antibody Fc portion. | 12-08-2011 |
20120295327 | Targeted Therapeutic Proteins - Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic agent and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic upon internalization of the receptor. Nucleic acids, cells, and methods relating to the practice of the invention are also provided. | 11-22-2012 |
20130011381 | MODIFIED ENZYME TREATMENT METHOD - Disclosed is a method for the treatment of lysosomal storage disease in mammals wherein the mammal is administered a therapeutically effective amount of an isolated, modified recombinant β-glucuronidase whereby said storage diseased disease is relieved in the brain and visceral organs of the mammal. There is also disclosed an isolated, modified recombinant β-glucuronidase wherein the modification is having its carbohydrate moieties chemically modified so as to reduce its activity with respect to mannose and mannose 6-phosphate cellular delivery system while retaining enzymatic activity. Also disclosed are other lysosomal enzymes within the scope of the invention. | 01-10-2013 |