Skerka
Christina Skerka, Jena DE
Patent application number | Description | Published |
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20110236455 | Novel Regulators of the Innate Immune System - The present invention relates to the identification of novel regulators of the innate immune system, in particular the complement system. More particularly, the present invention relates to specific C5 convertase inhibitors. These novel inhibitors are particularly useful for treating inflammatory diseases involving the complement system. In a first aspect, the present invention focuses on the use of CFHR proteins and functional fragments or functional derivatives thereof for preventing inflammatory reactions. In a further aspect, the present invention focuses on the use of said CFHR proteins for inactivating complement activation during transplantation and dialysis and for coating devices which come into contact with blood or body fluids, in particular implants. The invention furthermore provides a pharmaceutical composition comprising functional CFHR protein in combination with functional factor H. In a further aspect, the present invention focuses on providing monoclonal antibodies which specifically detect CFHR proteins, and on the use thereof in methods of determining CFHR in body fluids. These methods are particularly suitable for diagnosing inflammatory diseases. | 09-29-2011 |
Christine Skerka, Jena DE
Patent application number | Description | Published |
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20090118163 | Factor H for the Treatment of Chronic Nephropathies and Production thereof - The invention is directed to novel uses of Factor H, in particular in antibody-independent chronic nephropathies, e.g. in tubulointerstitial fibrosis (TIF). The invention is further directed to novel large scale manufacturing processes for Factor H. | 05-07-2009 |
20110046062 | FACTOR H FOR THE TREATMENT OF CHRONIC NEPHROPATHIES AND PRODUCTION THEREOF - The invention relates to the use of Factor H for the manufacture of a medicament to treat both chronic nephropathies which are not causally associated with proteinuria and chronic nephropathies which are causally associated with proteinuria. The invention also relates to large scale purification methods for Factor H. | 02-24-2011 |
Wolfgang Skerka, Rendsburg DE
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20110119939 | METHOD FOR OPERATING A DISPLAY DEVICE DRIVEN BY AT LEAST ONE STEPPING MOTOR - Method for operating a display device driven by at least one stepping motor with display scales, having the following steps: determining suitable step widths at least in ranges affected by stroboscopic flicker effects when driving in each case one stepping motor for moving the display scale in a measuring run when starting the instrument or on request, storing the determined step widths in the form of a matching parameter, and operating the stepping motor(s) with a suitable step-width resolution in the ranges that are identified as affected by the stroboscopic flicker effects to be avoided. | 05-26-2011 |