Showalter, US
Adrian Showalter, Yakima, WA US
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20160004825 | ONTOLOGICAL MEDICAL CODING METHOD, SYSTEM, AND APPARATUS - Diagnosis and procedure terminology are ontologically organized according to context-based categories and medical concepts. The medical concepts are linked to aliases and medical codes used to document patient care. A user is guided to select and document additional medical concepts based on a medical concept dependency that has been created between certain medical concepts, some of which are required. A visual concept tree presents for user consideration all categories and medical concepts necessary to determine appropriate medical codes based on the disease, condition or injury in accordance with a ranking algorithm and user documentation preferences. Potential medical codes are also optionally presented for user consideration based on collected documentation and selected medical concepts. | 01-07-2016 |
Armen M. Showalter, Indian Valley, VA US
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20140252774 | WIND, SOLAR, AND MAGNETIC ELECTRICAL GENERATION SYSTEM - The invention provides a system, apparatus and method for generating continuous electricity from a variety of sources, using high torque, high efficiency motors, and optionally a wind turbine to operate at least one generator. | 09-11-2014 |
Brett Showalter, New Market, MD US
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20090186859 | DIAZENIUMDIOLATED NON-STEROIDAL ANTI-INFLAMMATORY DRUGS, COMPOSITIONS THEREOF, AND RELATED METHODS - Disclosed are compounds that release nitric oxide, e.g., a compound of Formula (I) wherein R | 07-23-2009 |
Brett Showalter, Naperville, IL US
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20140050640 | MERCURY SORBENTS - Disclosed herein are methods for the on-site manufacture of aqueous-based mercury sorbent compositions prepared using a process water. The sorbent compositions may be aqueous-based materials manufactured from a silica containing precursor, a metal species, and a sulfur-based species, in the presence of a process waters, such as a process water from a coal-fired power plant. | 02-20-2014 |
20140050641 | MERCURY SORBENTS - Disclosed are methods for the on-site manufacture of aqueous-based mercury sorbent compositions prepared using a process water. The sorbent compositions may be aqueous-based materials manufactured from a silica containing precursor, a metal species, and a sulfur-based species, in the presence of a process waters, such as a process water from a coal-fired power plant. | 02-20-2014 |
Brett Showalter, Wheaton, IL US
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20130036946 | SILICA PARTICLE MANUFACTURING PROCESS - Methods of forming a silica-containing products are disclosed. One method comprises: (a) providing a silica containing precursor (SCP) contained in solution that has a pH less than or equal to a pH of 7; (b) optionally doping the SCP with one or more metal species; (d) adding an effective amount of salt to the solution so that the conductivity of the solution is greater than or equal to 4 mS; (e) optionally filtering and drying the SCP; and (f) optionally reacting the dried product from step e with a functional group. Another method comprises: (a) providing a silica containing precursor (SCP) contained in solution that has a pH greater than 7; (b) adjusting the pH of the solution to less than or equal to 7; (c) optionally doping the SCP with one or more metal species; (d) adjusting the pH of the solution to greater than 7; and (e) adding an effective amount of salt to the solution so that the conductivity of the solution is greater than or equal to 4 mS; (f) optionally filtering and drying the SCP; The SCP is then added to a hygroscopic solid such that the resulting product comprises a metal oxide-doped or metal sulfide-doped silica-containing product deposited on a substrate selected from hydrated alkaline earth oxide, lanthanide oxide, and combinations thereof. | 02-14-2013 |
Brett M. Showalter, Wheaton, IL US
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20090264321 | COMPOSITION AND METHOD FOR RECOVERING HYDROCARBON FLUIDS FROM A SUBTERRANEAN RESERVOIR - This invention is directed to a composition comprising encapsulated expandable polymeric microparticles including expandable base microparticles encapsulated in a shell of at least one layer of a labile or degradable encapsulation material. The encapsulated microparticles have an unexpanded volume average particle size diameter of from about 0.05 to about 5,000 microns. The invention is further directed to the use of the composition for modifying the permeability of subterranean formations and increasing the mobilization and/or recovery rate of hydrocarbon fluids present in the formations. | 10-22-2009 |
20110046238 | CALCIUM BASED CARRIER PARTICLES - The present invention relates to a method for forming a calcium-based carrier particle consisting of the calcium-based material, an active, with or without a surface modification, a stabilizing agent, and the related composition. The calcium-based particle is illustrated by the general formula Ca | 02-24-2011 |
20110046239 | CALCIUM BASED CARRIER PARTICLES - The present invention relates to a method for forming a calcium-based carrier particle consisting of the calcium-based material, an active, with or without a surface modification, a stabilizing agent, and the related composition. The calcium-based particle is illustrated by the general formula Ca | 02-24-2011 |
20110046240 | CALCIUM-BASED CARRIER PARTICLES - The present invention relates to a method for forming a calcium-based carrier particle consisting of the calcium-based material, an active, with or without a surface modification, a stabilizing agent, and the related composition. The calcium-based particle is illustrated by the general formula Ca | 02-24-2011 |
20110046241 | CALCIUM BASED CARRIER PARTICLES - The present invention relates to a method for forming a calcium-based carrier particle consisting of the calcium-based material, an active, with or without a surface modification, a stabilizing agent, and the related composition. The calcium-based particle is illustrated by the general formula Ca | 02-24-2011 |
20110251057 | SILICA PARTICLE MANUFACTURING PROCESS - Methods of forming a silica-based products are disclosed. One method comprises: (a) providing a silica containing precursor (SCP) contained in solution that has a pH less than or equal to a pH of 7; (b) optionally doping the SCP with one or more metal species, wherein said doping occurs when the solution has a pH less than or equal to a pH of 7; (c) adjusting the pH of the solution to greater than 7; (d) adding an effective amount of salt to the solution so that the conductivity of the solution is greater than or equal to 4 mS, wherein said addition occurs prior to, simultaneous with, or after the pH adjustment in step 1c; (e) optionally filtering and drying the SCP; and (f) optionally reacting the dried product from step e with a functional group and optionally wherein the resultant functionalized dried product is at least one of the following: a functionalized metal oxide-doped or metal sulfide-doped silica product. Another method comprises: (a) providing a silica containing precursor (SCP) contained in solution that has a pH greater than 7; (b) adjusting the pH of the solution to less than or equal to 7; (c) optionally doping the SCP with one or more metal species, wherein said doping occurs when the solution has a pH less than or equal to a pH of 7; (d) adjusting the pH of the solution to greater than 7; (e) adding an effective amount of salt to the solution so that the conductivity of the solution is greater than or equal to 4 mS, wherein said addition occurs prior to, simultaneous with, or after the pH adjustment in step 2d; (f) optionally filtering and drying the SCP; and (g) optionally reacting the dried product from step f with a functional group and optionally wherein the resultant functionalized dried product is at least one of the following: a functionalized metal oxide-doped or metal sulfide-doped silica product. | 10-13-2011 |
Brian D. Showalter, Dalton, OH US
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20080301925 | HAND TOOL FOR REMOVING AND INSTALLING RUBBER COMPONENTS ON MILKING EQUIPMENT - A pliers-like hand tool is configured to install rubber or elastomeric components on rigid components and to remove them from rigid components, such as found in milking equipment. Some embodiments of the hand tool include attachment mounts for mounting various attachments used for the installation and/or removal of specific elastomeric components. The hand tool is configured for removal of elastomeric hoses from rigid pipes. The hand tool is also useful for installing an elastomeric inflation of a teat cup assembly within its shell and for removing it therefrom. | 12-11-2008 |
Dan Showalter, Suttons Bay, MI US
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20150060222 | Actuator for Multi-Mode Clutch Module - A transmission clutch module including inner and outer races, a plurality of race engaging pawls and an actuator ring incorporates an actuator having a rotatable spool header adapted to rotate an attached actuator lever between at least two angular positions. The actuator lever moves the actuator ring to selectively block the pawls so inner and outer races may freewheel relative to one another in at least one operating mode. The actuator may be electric or hydraulic powered, and may be spring-biased to a default position in event of power failure. An elongated axially moveable plunger is secured to and supported within a piston at a first end, and has a radially extending pin at its second end. A fixed spool sleeve to which the spool header is supported includes a helical slot through which the pin extends. As the plunger moves reciprocally, the pin undergoes both translational and rotational movement. | 03-05-2015 |
Dan Showalter, Plymouth, MI US
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20100316519 | FRICTION DRIVE PUMP FOR TRANSFER CASES, ETC. - A pump having an actuator mounted on a rotatable shaft, and a pump mounted on the shaft, which is selectively engageable with the actuator. When the actuator is actuated, the pump will receive rotational force from the shaft, creating a pumping action. | 12-16-2010 |
Dan J. Showalter, Plymouth, MI US
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20090112430 | Electronic Control Torque Vectoring Axle - The present invention is an axle ( | 04-30-2009 |
20090118053 | ACTIVE CONTROL CENTER DIFFERENTIAL WITH FRONT OUTPUT - A coupling device ( | 05-07-2009 |
20090200131 | OUTER HOUSING GEOMETRY FOR ALIGNING CLUTCH PLATES - An outer housing for a clutch assembly that allows for the housing to be placed over an already assembled multi-disc clutch pack. The outer housing incorporates a plurality of internally splined grooves, a lead-in chamfer to assist in the alignment of the center line between the housing and the center line of the clutch pack, and an index chamfer on elevated ridges that reside between the splined grooves to assist in the alignment of the splined teeth of outer clutch plates in the assembled clutch pack with said splined grooves. | 08-13-2009 |
20090253548 | TORQUE VECTORING AXLE ASSEMBLY - In at least one embodiment of the present invention, a torque vectoring axle assembly for a non-driven axle of a motor vehicle is provided. The assembly comprises a first torque vectoring system ( | 10-08-2009 |
20150176708 | SPRING LOADED SHIFT ACTUATOR ASSEMBLY HAVING A RETAINING MECHANISM - The present invention is directed toward a shift actuator assembly that includes a housing having a retaining mechanism. A holding pawl is biased into engagement with the retaining mechanism. A solenoid releasably engages the pawl when the shift shaft is disposed in its first position such that once the solenoid disengages the pawl, the cam surfaces on the retaining mechanism cooperate with the holding surfaces on the pawl to drive the pawl out of engagement with the retaining mechanism thereby releasing the biasing force of the biasing mechanism to drive the housing and the shift fork axially on the shift shaft between engaged and disengaged positions with respect to the associated gear set. | 06-25-2015 |
20150198131 | ANTI-KICKBACK CLUTCH FOR STARTER GEAR - In a permanently engaged starter system ( | 07-16-2015 |
20150315939 | SPLIT RING GEAR PLANETARY CAM PHASER - A cam phaser ( | 11-05-2015 |
20150345345 | ELECTRIC MOTOR DRIVEN SIMPLE PLANETARY CAM PHASER - A cam phaser ( | 12-03-2015 |
Dan Joseph Showalter, Plymouth, MI US
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20110319214 | ELECTROMAGNETIC CLUTCH DISCONNECT FOR ACCESSORY DRIVE - An automotive accessory drive system for a motor vehicle connects to an internal combustion engine crankshaft during at least one mode of operation. The system includes an accessory drive pulley, a starter motor/generator, and an endless loop power transmission member connecting at least the starter motor/generator and the accessory drive pulley. A planetary gear set includes a sun gear, a ring gear integrally associated with the accessory drive pulley, and a planetary carrier connected to the engine crankshaft. First and second one way clutches connect the engine crankshaft to the ring gear, and the sun gear to a grounding member, respectively, to define a normal drive mode and an engine start mode, respectively. An electromagnetic disconnect includes a normally closed friction clutch connecting the grounding member to ground to define a third mode of operation corresponding to a free wheel function with the grounding member disengaged from connection to ground. | 12-29-2011 |
David Lee Showalter, Barbouseville, VA US
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20130326854 | Hand Tool for Use in the Quick Disconnection of Quick Connect/Disconnect Couplings - A tool for the removal of connectors from pipes is disclosed that, in one embodiment, enables the removal of connectors from large pipes and in another embodiment from a size range of pipes. Movable and stationary gripping and pushing elements are affixed to handles to enable a pipe to be firmly gripped between a movable gripping jaw and a stationary gripping jaw and the connector prevented from movement by the movable pusher jaw and the stationary pusher jaw. The handles can compress around a pivot point or slide on a bar. In another embodiment the movable and stationary gripping and pushing elements are removable from the body of the tool. | 12-12-2013 |
Edward Showalter, Taft, CA US
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20160113426 | SHOE HORN APPARATUS AND METHOD - A shoe horn apparatus comprising: a handle at one end, a shoe horn at the other end and a shaft mounted between the handle and the shoe horn, wherein the shaft is attached at its upper end to the handle and at its lower end to the shoe horn; a spring loaded actuating member mounted near the handle, such that it can be actuated by a user with the same hand the user holds the handle with; a spring loaded grip member mounted near the shoe horn such that it can grip the back of a shoe between the back of the shoe horn and the grip member upon actuation or release of the actuating member by a user; and, a transmission mechanism mounted between the actuating member and the grip member. | 04-28-2016 |
Geofrey Showalter, Moriarty, NM US
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20140097093 | Transformerless On-Site Generation - Methods and apparatuses for electrolysis that does not require the use of a transformer to operate. The apparatus comprises one or more electrolytic cells which comprise the number of intermediate electrodes sufficient to enable the cell or cells to operate at the rectified line voltage without any need for voltage regulation, or near the rectified line voltage with only some voltage regulation, such as less than 20% of the rectified line voltage. Such regulation is achieved by using a buck or boost converter rather than a transformer, and can be varied to accommodate fluctuations in the line voltage and/or conductivity of the electrolyte, or varied to produce different chemistries in the same apparatus. | 04-10-2014 |
Geofrey C. Showalter, Moriarty, NM US
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20140124378 | Electrolytic On-Site Generator - Method and apparatus for a low maintenance, high reliability on-site electrolytic generator incorporating automatic cell monitoring for contaminant film buildup, as well as automatically removing or cleaning the contaminant film. This method and apparatus preferably does not require human intervention to clean. For high current density cells, cleaning is preferably performed by reversing the polarity of the electrodes and applying a lower current density to the electrodes, preferably by adjusting the salinity or brine concentration of the electrolyte while keeping the voltage constant. Electrolyte flow preferably comprises water and brine flows which are preferably separately monitored and automatically adjusted. For bipolar cells, flow between modules arranged in parallel is preferably approximately equally distributed between modules and between intermediate electrodes within each module. | 05-08-2014 |
Gregory J. Showalter, West Seneca, NY US
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20090107764 | Lower ladder support - The lower ladder support is a device adapted for use with a two-railed ladder of the extension type and functions to prevent the ladder from moving, sliding or kicking back during use. The device includes identical support assemblies attached to the rails of the ladder at a lower portion thereof. Each assembly includes a channel, a circular plate having an array of apertures therein, a strap-plate member and rods for attaching the strap-plate, circular plate and channel to a respective rail. The channel is dimensioned to receive and removably retain an elongate, inexpensive, 2×4 wood stock member or similar member therein. The 2×4 member functions as an additional support leg for the ladder. | 04-30-2009 |
H.d. H. Showalter, Ann Harbor, MI US
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20110166144 | Pyrimidotriazinediones and Pyrimidopyrimidinediones and Methods of Using the Same - The present disclosure is directed to pyrimidotriazinediones and pyrimidopyrimidinediones having a formula (I), (II), or (III), or a mixture or pharmaceutically acceptable salt or hydrate thereof, and to methods of treating cancer comprising administering the same. | 07-07-2011 |
Hollis Showalter, Ann Arbor, MI US
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20100035852 | COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS OF THE BOWEL - The present invention provides compositions and methods for treating inflammatory conditions (e.g., of the bowel). In particular, the present invention provides methods of treating (e.g., therapeutically and/or prophylactically treating) inflammatory conditions (e.g., of the bowel), compositions useful for such methods (e.g., antagonists and/or inhibitors of angiotensin II (AngII) receptor Type 1 | 02-11-2010 |
20150284387 | SMALL MOLECULE INHIBITORS OF MCL-1 AND USES THEREOF - This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having pyrazolopyridine structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases. | 10-08-2015 |
Hollis D. Showalter, Ann Arbor, MI US
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20120077806 | Deubiquitinase Inhibitors and Methods for Use of the Same - Disclosed herein are methods of inhibiting a deubiquitinase (DUB), methods of treating pathogenic infections (e.g., viral, bacterial, and/or parasitic), methods of inhibiting cell proliferation, methods of treating a neurodegenerative disease, methods of treating one or more symptoms of a neurodegenerative disease or a genetic disorder, and compounds. | 03-29-2012 |
20140235702 | SMALL MOLECULE INHIBITORS OF MCL-1 AND THE USES OF THEREOF - This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having sulfonamido-1-hydroxynaphthalene structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases. | 08-21-2014 |
20140329848 | DEUTERATED AMLEXANOX - Provided herein is technology relating to deuterated amlexanox and particularly, but not exclusively, to compositions comprising deuterated amlexanox, methods of producing deuterated amlexanox, and uses of deuterated amlexanox. | 11-06-2014 |
20140357673 | Deubiquitinase Inhibitors and Methods for Use of the Same - Disclosed herein are methods of inhibiting a deubiquitinase (DUB), methods of treating pathogenic infections (e.g., viral, bacterial, and/or parasitic), methods of inhibiting cell proliferation, methods of treating a neurodegenerative disease, methods of treating one or more symptoms of a neurodegenerative disease or a genetic disorder, and compounds. | 12-04-2014 |
20160060271 | DEUTERATED AMLEXANOX - Provided herein is technology relating to deuterated amiexanox and particularly, but not exclusively, to compositions comprising deuterated amiexanox, methods of producing deuterated amiexanox, and uses of deuterated amiexanox. Provided herein are deuteratecl amiexanox compounds for the treatment of obesity, insulin resistance, diabetes, and steatosis. In addition, the deuterated compounds are anti-inflammatory antiallergic immunomodulators. e.g., for the treatment of diseases associated with inflammation. The deuterium kinetic isotope effect associated with placing deuterium at the site of metabolic derivatization slows metabolic derivatization and thus increases the lifetime of the active drug in vivo. | 03-03-2016 |
Holly Showalter, Wes Des Moines, IA US
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20100280286 | Process For The Preparation of Beta and Alpha Cryptoxanthin - The present invention relates to a process for converting lutein and/or lutein esters to (3R)-β-cryptoxanthin and (3R,6′R)-α-cryptoxanthin, suitable for human consumption as dietary supplements, by employing safe and environmentally friendly reagents. (3R)-β-Cryptoxanthin and (3R,6′R)-α-cryptoxanthin are two rare food carotenoids that are not commercially available and the former exhibits vitamin A activity. In the first synthetic step, commercially available lutein and/or lutein esters are transformed into a mixture of dehydration products of lutein (anhydroluteins) in the presence of a catalytic amount of an acid. The resulting anhydroluteins are then converted to (3R)-β-cryptoxanthin (major product) and (3R,6′R)-α-cryptoxanthin (minor product) by heterogeneous catalytic hydrogenation employing transition elements of group VIII (Pt, Pd, Rh supported on alumina or carbon) in a variety of organic solvents under atmospheric pressure of hydrogen and at temperatures ranging from −15° C. to 40° C. Among these catalysts, Pt supported on alumina at 40° C. in ethyl acetate provides the best yield of (3R)-β-cryptoxanthin and (3R,6′R)-α-cryptoxanthin. Several homogeneous catalysts can also promote the regioselective hydrogenation of anhydroluteins to a mixture of (3R)-β-cryptoxanthin and (3R,6′R)-α-cryptoxanthin in low to moderate yields. The catalysts may be transition metal complexes such as palladium acetylacetonate, Rh(Ph | 11-04-2010 |
Holly Showalter, Waukee, IA US
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20080233222 | Method of Improving Cardiovascular Health - A nutritional supplement including β-cryptoxanthin is found to be effective at lowering blood pressure in mammals. β-cryptoxanthin therefore may be used to maintain cardiovascular health by lowering blood pressure, preventing high, elevated blood pressure and/or maintaining healthy blood pressure. Administration of β-cryptoxanthin in combination with safflower oil is particularly effective. | 09-25-2008 |
James Lee Showalter, Los Gatos, CA US
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20090198708 | METHOD AND APPARATUS FOR MANAGING METADATA ASSOCIATED WITH ENTITIES IN A COMPUTING SYSTEM - One embodiment of the present invention provides a system that facilitates managing metadata associated with entities and entity types in a computing system. During operation, the system initializes a global static metadata cache containing global static metadata at the computing system. Next, the system initializes a global dynamic metadata cache containing global dynamic metadata at the computing system. The system then receives a command to initialize a session at the computing system. In response to the command, the system determines a realm for the session, wherein the realm is a virtual private partition of the computing system. The system then initializes a realm-scoped dynamic metadata cache containing realm-scoped dynamic metadata associated with the realm at the computing system. Finally, the system executes operations on the computing system in compliance with the global static metadata, the global dynamic metadata, and the realm-scoped dynamic metadata. | 08-06-2009 |
20100095311 | METHOD AND APPARATUS FOR FACILITATING A PERSISTENCE APPLICATION PROGRAMMING INTERFACE - One embodiment of the present invention provides a system for implementing a persistence application programming interface (API) that is platform independent and can make up-calls to business logic. During operation, the system receives a request at the API to execute a command at a persistence tier of an n-tier distributed application. In response to the request, the system determines an entity type for an entity affected by the command. Next, the system identifies a function at a middle tier of the n-tier distributed application that is associated with the entity type and the command, wherein the middle tier includes the business logic. The system then sends an instruction to the middle tier to execute the function. Finally, upon receiving a confirmation at the API that the function executed, the system executes the command at the persistence tier. | 04-15-2010 |
James M. Showalter, Endwell, NY US
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20100174752 | VALIDATION AND CORRECTION IN A DISTRIBUTED NAMESPACE - A method comprising, sending an instruction from a validator member of a sysplex to a second member of a sysplex to prevent operations that alter a sysplex namespace, determining whether the validator member of the sysplex is communicative with the second member of the sysplex and whether the members of the sysplex retain current sysplex status information, sending an instruction from the validator member to the second member to send a first namespace attribute data associated with the second member to the validator member responsive to determining that the validator member of the sysplex is communicative with the second member of the sysplex and the members of the sysplex retain current sysplex status information, determining whether the first namespace attribute data associated with the second member is consistent with a second namespace attribute data, and sending an instruction to correct the first namespace attribute data. | 07-08-2010 |
Patrick F. Showalter, Louisville, KY US
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20120204491 | Hinge Assemblies for Door Lids and Methods of Their Delivery - A hinge assembly for a door lid of a vehicle includes a hinge arm support bracket that mounts within a luggage compartment of the vehicle. A hinge arm is connected to the support bracket at a proximal portion and including a distal portion that is mountable to the door lid, the hinge arm being pivotable relative to the support bracket. A force adjustment member is pivotally connected to the hinge arm. The force adjustment member includes a torsion bar mount portion extending outwardly from the hinge arm having an opening therethrough to receive an end of a torsion bar and a tool receiving portion that engages a torque adjustment tool to pivot the force adjustment member to apply a torque to the torsion bar. | 08-16-2012 |
Rebecca L. Showalter, Raleigh, NC US
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20150338294 | STRAIN GAGES WITH DISCRETE ELECTRICAL RESISTANCE TRIMMING - An electrical resistance strain gage includes a uniformly distributed electrical resistance of the active measuring area and a discrete electrical trim resistance within an active measuring are. The trim resistance may include an electrical conductor in an electrically parallel circuit such that the electrical conductor may be selectively electrically removed from the strain gage to trim the electrical resistance of the strain gage. The trim resistance does not modify the active strain sensing area or uniform grid length. | 11-26-2015 |
Richard Showalter, El Cajon, CA US
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20160074487 | ARGININE DEIMINASE WITH REDUCED CROSS-REACTIVITY TOWARD ADI - PEG 20 ANTIBODIES FOR CANCER TREATMENT - The present invention relates generally to isolated to arginine deiminase (ADI) proteins that have reduced cross-reactivity with anti-ADI-PEG 20 antibodies as compared to ADI-PEG 20, but which can have functional characteristics comparable to or better than ADI-PEG 20, compositions comprising the ADI proteins, and related methods of treating arginine-dependent diseases or related diseases such as cancer. | 03-17-2016 |
Richard E. Showalter, El Cajon, CA US
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20140348814 | ARGINNE DEIMINASE WITH REDUCED CROSS-REACTIVITY TOWARD ADI - PEG 20 ANTIBODIES FOR CANCER TREATMENT - The present invention relates generally to isolated to arginine deiminase (ADI) proteins that have reduced cross-reactivity with anti-ADI-PEG 20 antibodies as compared to ADI-PEG 20, but which can have functional characteristics comparable to or better than ADI-PEG 20, compositions comprising the ADI proteins, and related methods of treating arginine-dependent diseases or related diseases such as cancer. | 11-27-2014 |
Robert Showalter, Denver, CO US
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20080222949 | Devices and methods for growing plants - A gardening system includes a modular seed cartridge including a rigid, cup-shaped receptacle including an upper portion having an outer rim, a soilless growth medium located in the rigid, cup-shaped receptacle, and at least one seed in contact with the soilless growth medium. The gardening system also includes an aeroponic or hydroponic garden including a chamber including a lower portion for storing a liquid nutrient solution, a cover located above the chamber, the cover including a plant opening adapted to removably support the modular seed cartridge by the outer rim, and a pump located in the chamber and adapted to circulate the liquid nutrient solution from the lower portion of the chamber to the modular seed cartridge supported by the plant opening. | 09-18-2008 |
20080282610 | Devices and methods for growing plants - A soilless garden includes a chamber including a sealed lower portion for storing liquid nutrient solution, and an upper portion including a support structure; soilless growth medium supported by the support structure and adapted to support at least one plant having roots; a removable germination cap located above the soilless growth medium; a conduit having a first end located substantially adjacent to the soilless growth medium, and a second end opposite to the first end; and a pump in the chamber, including an input for receiving the liquid nutrient solution from the lower portion of the chamber, and an output to deliver liquid nutrient solution through the conduit into the soilless growth medium. The support structure includes an opening directed toward the lower portion of the chamber for the liquid nutrient solution to drip from the roots of the at least one plant into the lower portion of the chamber. | 11-20-2008 |
Rodney L. Showalter, Dalton, OH US
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20080301925 | HAND TOOL FOR REMOVING AND INSTALLING RUBBER COMPONENTS ON MILKING EQUIPMENT - A pliers-like hand tool is configured to install rubber or elastomeric components on rigid components and to remove them from rigid components, such as found in milking equipment. Some embodiments of the hand tool include attachment mounts for mounting various attachments used for the installation and/or removal of specific elastomeric components. The hand tool is configured for removal of elastomeric hoses from rigid pipes. The hand tool is also useful for installing an elastomeric inflation of a teat cup assembly within its shell and for removing it therefrom. | 12-11-2008 |
Ryan Showalter, Fresno, CA US
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20120265597 | SYSTEMS AND METHODS FOR FACILITATING PROMOTIONS - Embodiments of the present invention include systems and methods for providing incentives/promotion systems to users and businesses. Embodiments comprise an Internet-based platform enabling businesses to create and maintain their own reward programs and manage customers participating in them. In embodiments, businesses can customize, according to one or more factors (which factors may be obtained from data stored in the system), and track deals and other offerings to customers, potential customers, or both. Embodiments of the platform enable customers to view each business's rewards program, acquire and track rewards and other offering from multiple businesses using a single account offered via the platform. In embodiments, the centralized system allows users, businesses, or both to collaboratively create, promote, and/or redeem promotional activities. | 10-18-2012 |
Samuel J. Showalter, Verona, VA US
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20130125570 | HIGH CAPACITY CHILLER COMPRESSOR - A high efficiency, low maintenance single stage or multi-stage centrifugal compressor assembly for large cooling installations. A cooling system provides direct, two-phase cooling of the rotor by combining gas refrigerant from the evaporator section with liquid refrigerant from the condenser section to affect a liquid/vapor refrigerant mixture. Cooling of the stator with liquid refrigerant may be provided by a similar technique. A noise suppression system is provided by injecting liquid refrigerant spray at points between the impeller and the condenser section. The liquid refrigerant may be sourced from high pressure liquid refrigerant from the condenser section. | 05-23-2013 |
Thomas Showalter, Maitland, FL US
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20150127415 | SYSTEMS, METHODS AND COMPUTER READABLE MEDIA FOR GENERATING A MULTI-DIMENSIONAL RISK ASSESSMENT SYSTEM INCLUDING A MANUFACTURING DEFECT RISK MODEL - Some implementations can include a computerized method, system or computer readable media for generating a manufacturing defect risk assessment model. The method can include obtaining training data for a plurality of loans, the training data can include loan information and a forensic audit finding and deficiency code associated with each loan. The method can also include cleaning the training data to obtain data associated with a time of origination for each loan, and enriching the training data for each loan by adding additional data. The method can further include grouping deficiency codes into one or more classes of defects, in which each class includes one or more related defect codes. The method can also include selecting one or more variables for the manufacturing risk assessment model and assigning a coefficient to each selected variable. | 05-07-2015 |
20150127416 | SYSTEMS, METHODS AND COMPUTER READABLE MEDIA FOR MULTI-DIMENSIONAL RISK ASSESSMENT - Some implementations can include a computerized method, system or computer readable media for multi-dimensional risk assessment. The method can include obtaining loan application data and preprocessing the loan application data including limit checking values and augmenting the loan application data with information from external sources. The method can further include selecting scoring values corresponding to key scoring variables and scoring the application by processing the scoring values in a multi-dimensional risk assessment system including an operational risk model. | 05-07-2015 |
Thomas Showalter, Trabuco Canyon, CA US
Patent application number | Description | Published |
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20110270779 | DATA ANALYTICS MODELS FOR LOAN TREATMENT - Data analytics are provided in loan treatment. Various sources of data may be used to optimize or predict value for a loan. Using machine-learning and/or statistical analysis, loans or treatment best suited for a particular borrower may be determined. Due to the large amounts of data available, borrower behavior may be learned from previous behavior of others and mapped to a predictive model. Machine-learning indicates the most relevant factors in loan treatment, providing a matrix for predicting loan value or treatment success. A given borrower may be classified into one of many classes of borrower based on credit information, property information, desired loan information, real estate market information, and/or other data. Tens, hundreds, or even thousands of variables may be used to predict the optimum treatment. | 11-03-2011 |
20130297489 | Data Analytics Models for Loan Treatment - Data analytics are provided in loan treatment. Various sources of data may be used to optimize or predict value for a loan. Using machine-learning and/or statistical analysis, loans or treatment best suited for a particular borrower may be determined. Due to the large amounts of data available, borrower behavior may be learned from previous behavior of others and mapped to a predictive model. Machine-learning indicates the most relevant factors in loan treatment, providing a matrix for predicting loan value or treatment success. A given borrower may be classified into one of many classes of borrower based on credit information, property information, desired loan information, real estate market information, and/or other data. Tens, hundreds, or even thousands of variables may be used to predict the optimum treatment. | 11-07-2013 |
20150026035 | DATA ANALYTICS MODEL FOR LOAN TREATMENT - Data analytics are provided in loan treatment. Various sources of data may be used to optimize or predict value for a loan. Using machine-learning and/or statistical analysis, loans or treatment best suited for a particular borrower may be determined. Due to the large amounts of data available, borrower behavior may be learned from previous behavior of others and mapped to a predictive model. Machine-learning indicates the most relevant factors in loan treatment, providing a matrix for predicting loan value or treatment success. A given borrower may be classified into one of many classes of borrower based on credit information, property information, desired loan information, real estate market information, and/or other data. Tens, hundreds, or even thousands of variables may be used to predict the optimum treatment. | 01-22-2015 |
Todd Showalter, Clemmons, NC US
Patent application number | Description | Published |
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20110257168 | DERIVATIVES OF OXABISPIDINE AS NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS - The present invention relates to compounds of formula (I) that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS). | 10-20-2011 |
20140249141 | 1,4-DIAZABICYCLO[3.2.2]NONANES AS NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS - The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including inflammatory diseases and diseases associated with dysfunction of the central nervous system (CNS). | 09-04-2014 |
20140288169 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS - The present invention relates to compounds that modulate nicotinic receptors as non-competitive antagonists, methods for their synthesis, methods for their use, and their pharmaceutical compositions. | 09-25-2014 |
Todd William Showalter, Derby, KS US
Patent application number | Description | Published |
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20140001817 | MULTI-FUNCTION DUMP CART | 01-02-2014 |
Wayne Showalter, Tucson, AZ US
Patent application number | Description | Published |
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20090017491 | APPARATUS AND METHOD FOR BIOLOGICAL SAMPLE PROCESSING - An apparatus and method are described that achieve independent and simultaneous processing of a plurality of substrate-supported biological samples. In one embodiment, substrate holders arranged in a minor arc are independently moveable between a processing position and an access position, and reagents are delivered to substrates held in the substrate holders through a nozzle plate that moves along the arc of substrate holders. The disclosed apparatus and method are particularly suited for implementation of lean processing of biological samples. | 01-15-2009 |
20100255532 | Automated Molecular Pathology Apparatus Having Fixed Slide Platforms - Apparatus and methods for automatically staining or treating multiple tissue samples mounted on slides are provided, in which the slides and reagent bottles are held in fixed position, and the reagent, wash and coverslipping solutions brought to the slides. Alternatively, the slides are held in fixed position, while the reagent, wash and coverslipping solutions brought to the slides. | 10-07-2010 |
20110168744 | METHOD AND APPARATUS FOR MODIFYING PRESSURE WITHIN A FLUID DISPENSER - A fluid dispenser comprising a barrel having a reservoir chamber, the barrel having an upper portion, a cap connected to the reservoir chamber, the cap having a surface with at least one hole therethrough, a valve comprising a biasing member and a hole sealer, the valve being adjacent to the reservoir chamber, a coupler having a dispense chamber, and a vent located between the cap and the reservoir chamber, the vent including a vent opening and a vent material composed of oliophobic material. | 07-14-2011 |
20140178858 | AUTOMATED HIGH VOLUME SLIDE PROCESSING SYSTEM - An automated system is provided for performing slide processing operations on slides bearing biological samples. In one embodiment, the disclosed system includes a slide tray holding a plurality of slides in a substantially horizontal position and a workstation that receives the slide tray. In a particular embodiment, a workstation delivers a reagent to slide surfaces without substantial transfer of reagent (and reagent borne contaminants such as dislodged cells) from one slide to another. A method for automated processing of slides also is provided. | 06-26-2014 |
20150031073 | APPARATUS AND METHOD FOR BIOLOGICAL SAMPLE PROCESSING - An apparatus and method are described that achieve independent and simultaneous processing of a plurality of substrate-supported biological samples. In one embodiment, substrate holders arranged in a minor arc are independently moveable between a processing position and an access position, and reagents are delivered to substrates held in the substrate holders through a nozzle plate that moves along the arc of substrate holders. The disclosed apparatus and method are particularly suited for implementation of lean processing of biological samples. | 01-29-2015 |