Shikhar
Shikhar Agarwal, Redwood City, CA US
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20150026153 | SEARCH ENGINE FOR INFORMATION RETRIEVAL SYSTEM - A search engine performs semantic analysis of unstructured search terms to generate relational database queries. By understanding the semantics, the search engine more effectively identifies and predicts what information the user is searching for and provides more in-depth user assistance. The search engine uses different ranking schemes to identify which data is most likely associated with search terms and provides both row level and object level data security. The search engine may identify ambiguous search requests and allows the user to select different join paths that create different mappings between the data. The search engine may generate worksheets containing the selected mappings. | 01-22-2015 |
Shikhar Fnu, Pittsburgh, PA US
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20130229663 | SPATIAL-DOMAIN LOW-COHERENCE QUANTITATIVE PHASE MICROSCOPY - Due to potential sampling errors (due to small tissue samples not necessarily directly from the developing tumor) and limited optical resolution (˜1 micron), cancer may be missed or detected too late for optimal treatment, or conservative interpretation of indeterminate findings could lead to unnecessary surgery. The novel technology herein—Spatial-domain Low-coherence Quantitative Phase Microscopy (SL-QPM)—can detect structural alterations within cell nuclei with nanoscale sensitivity (0.9 nm) (or nuclear nano-morphology) for “nano-pathological diagnosis” of cancer. SL-QPM uses original, unmodified cytology and histology specimens prepared with standard clinical protocols and stains. SL-QPM can easily integrate in existing clinical pathology laboratories. Results quantified the spatial distribution of optical path length or refractive index in individual nuclei with nanoscale sensitivity, which could be applied to studying nuclear nano-morphology as cancer progresses. The nuclear nano-morphology derived from SL-QPM offers significant diagnostic value in clinical care and subcellular mechanistic insights for basic and translational research. | 09-05-2013 |
20150204728 | SPATIAL-DOMAIN LOW-COHERENCE QUANTITATIVE PHASE MICROSCOPY - Systems, methods and other embodiments associated with spatial-domain Low-coherence Quantitative Phase Microscopy (SL-QPM) are described herein. SL-QPM can detect structural alterations within cell nuclei with nanoscale sensitivity (0.9 nm) (or nuclear nano-morphology) for “nano-pathological diagnosis” of cancer. SL-QPM uses original, unmodified cytology and histology specimens prepared with standard clinical protocols and stains. SL-QPM can easily integrate in existing clinical pathology laboratories. Results quantified the spatial distribution of optical path length or refractive index in individual nuclei with nanoscale sensitivity, which could be applied to studying nuclear nano-morphology as cancer progresses. The nuclear nano-morphology derived from SL-QPM offers significant diagnostic value in clinical care and subcellular mechanistic insights for basic and translational research. Techniques that provide for depth selective investigation of nuclear and other cellular features are disclosed. | 07-23-2015 |
Shikhar Gupta, Singapore SG
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20160074293 | Cosmetic Compositions and Methods for Inhibiting Melanin Synthesis - A cosmetic composition suitable for topical application, for example, is provided. In some examples, the cosmetic composition may include bisabolol, undecylenoyl phenylalanine and/or hexyldecanol, and a material selected from the group consisting of ethyl palmitate, stearyl alcohol, bis(2-ethylhexyl)adipate, bis(2-ethylhexyl)maleate, 5-pentadecanol, 1-stearoyl-rac-glycerol, bis(2-ethylhexyl)sebacate, and mixtures thereof. A method of reducing the synthesis of melanin by using the cosmetic compositions is also disclosed herein. | 03-17-2016 |