Sheryl
Sheryl Brown-Shimer, Boston, MA US
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20100167324 | Quantitative Assays for Ras p21 in Body Fluids - The present invention is directed to the detection and quantification of total ras p21 in body fluids, particularly serial changes of total ras p21 levels in a subject's body fluids. Further, the invention is directed to detecting and quantitatiing total ras p21 in conjunction with one or more other proteins, such as, oncoproteins, angiogenic factors, tumor markers, inhibitors, growth factor receptors, metastasis proteins, and tumor suppressors. The disclosed methods are diagnostic/prognostic for preneoplastic/neoplastic diseases, and useful to select therapies for patients with preneoplastic/neoplastic diseases. The disclosed methods are further useful to monitor the status of a patient's preneoplastic/neoplastic disease, and/or to monitor how a patient is responding to an anticancer therapy. | 07-01-2010 |
20140093890 | QUANTITATIVE ASSAYS FOR RAS P21 IN BODY FLUIDS - The present invention is directed to the detection and quantification of total ras p21 in body fluids, particularly serial changes of total ras p21 levels in a subject's body fluids. Further, the invention is directed to detecting and quantitating total ras p21 in conjunction with one or more other proteins, such as, oncoproteins, angiogenic factors, tumor markers, inhibitors, growth factor receptors, metastasis proteins, and tumor suppressors. The disclosed methods are diagnostic/prognostic for preneoplastic/neoplastic diseases, and useful to select therapies for patients with preneoplastic/neoplastic diseases. The disclosed methods are further useful to monitor the status of a patient's preneoplastic/neoplastic disease, and/or to monitor how a patient is responding to an anticancer therapy. | 04-03-2014 |
Sheryl Daake, Mckinney, TX US
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20110284791 | SPRING SEAT FOR USE WITH ACTUATORS - A spring seat for use with actuators is described herein. An example spring seat includes a body having a shoulder to receive an end of an actuator spring, a guide projecting away from the shoulder toward a first surface of the body, wherein the guide is configured to fit within an inner diameter of the coil spring to retain the end coil spring in engagement with the shoulder, and an aperture in a surface of the body opposite the guide, wherein the aperture is configured to receive an end of an adjuster of the pneumatic actuator such the aperture engages the adjuster to substantially reduce tilting of the body and buckling of the spring. | 11-24-2011 |
Sheryl Folck US
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20140171220 | BADGE FOR GOLF CLUB HEAD - The present disclosure concerns embodiments of a badge or insert for a golf club head that can eliminate undesired gaps between the insert and the peripheral sidewall of the cavity that receives the insert. In one embodiment, a golf club head comprises a main body comprising a cavity, which defines a central surface and an inner peripheral surface at least partially surrounding the central surface. An insert comprises a central portion and a deflectable portion coupled to and extending along a peripheral edge section of the central portion. The deflectable portion has a shape corresponding to and contacting a corresponding section of the inner peripheral surface of the cavity. The deflectable portion forms a press-fit engagement with the corresponding section of the inner peripheral surface of the cavity that retains the deflectable portion in a deflected state relative to the central portion. | 06-19-2014 |
Sheryl Folck, San Diego, CA US
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20150087441 | BADGE FOR GOLF CLUB HEAD - The present disclosure concerns embodiments of a badge or insert for a golf club head that can eliminate undesired gaps between the insert and the peripheral sidewall of the cavity that receives the insert. In one embodiment, a golf club head comprises a main body comprising a cavity, which defines a central surface and an inner peripheral surface at least partially surrounding the central surface. An insert comprises a central portion and a deflectable portion coupled to and extending along a peripheral edge section of the central portion. The deflectable portion has a shape corresponding to and contacting a corresponding section of the inner peripheral surface of the cavity. The deflectable portion forms a press-fit engagement with the corresponding section of the inner peripheral surface of the cavity that retains the deflectable portion in a deflected state relative to the central portion. | 03-26-2015 |
Sheryl Jones, New Market, AL US
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20110138509 | FLOWERING DOGWOOD TREE NAMED 'NM1' - A Flowering Dogwood named ‘NM1’ having a pink bracts that fade to white over the bloom period, vigorous upright growth with good branching, and mildew resistance and also capable of being reproduced reliably by vegetative propagation. | 06-09-2011 |
Sheryl Luttringer, Loomis, CA US
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20110053233 | Methods for improving malic acid production in filamentous fungi - The present invention relates to methods of producing a C4 dicarboxylic acid, comprising: (a) cultivating a filamentous fungal host cell comprising a polynucleotide selected from the group consisting of a heterologous first polynucleotide encoding a C4 dicarboxylic acid transporter, a heterologous second polynucleotide encoding a malate dehydrogenase, and a heterologous third polynucleotide encoding a pyruvate carboxylase; wherein the filamentous fungal host cell is capable of secreting increased levels of the C4 dicarboxylic acid compared to the filamentous fungal host cell without the heterologous polynucleotide when cultivated under the same conditions; and (b) recovering the C4 dicarboxylic acid. The present invention also relates to methods for increasing C4 dicarboxylic acid production, filamentous fungal host cells and malate dehydrogenase variants. | 03-03-2011 |
20110312046 | Methods for C4 Dicarboxylic Acid Production in Filamentous Fungi - The present invention relates to methods of producing C4-dicarboxylic acids, such as malic acid, comprising: (a) cultivating a host cell comprising a polynucleotide encoding a C4-dicarboxylic acid transporter; and (b) recovering the C4-dicarboxylic acid. The present invention also relates to methods for increasing C4-dicarboxylic acid production, as well as host cells comprising the polynucleotides. | 12-22-2011 |
20120219999 | Microorganisms for C4-Dicarboxylic Acid Production - The present invention relates to isolated polypeptides having bicarbonate transporter activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, and methods of producing C4-dicarboxylic acids, such as malic acid. | 08-30-2012 |
20130059353 | Recombinant Microorganisms for Production C4-Dicarboxylic Acids - Provided herein are host cells comprising carbonic anhydrase activity, wherein the cells are capable of producing C4-dicarboxylic acid. Also provided are methods of producing C4-dicarboxylic acid comprising (a) cultivating the host cells having carbonic anhydrase activity in a medium under suitable conditions to produce C4-dicarboxylic acid; and (b) recovering the C4-dicarboxylic acid. | 03-07-2013 |
20130288321 | Methods for Improved C4-Dicarboxylic Acid Production in Filamentous Fungi - The present invention relates to methods of producing C4-dicarboxylic acids, such as malic acid, comprising: (a) cultivating a host cell comprising a polynucleotide encoding a C4-dicarboxylic acid transporter; and (b) recovering the C4-dicarboxylic acid. The present invention also relates to methods for increasing C4-dicarboxylic acid production, as well as host cells comprising the polynucleotides. | 10-31-2013 |
20140134688 | Microorganisms for C4-Dicarboxylic Acid Production - The present invention relates to isolated polypeptides having bicarbonate transporter activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, and methods of producing C4-dicarboxylic acids, such as malic acid. | 05-15-2014 |
20140234925 | Methods for improving malic acid production in filamentous fungi - The present invention relates to methods of producing a C4 dicarboxylic acid, comprising: (a) cultivating a filamentous fungal host cell comprising a polynucleotide selected from the group consisting of a heterologous first polynucleotide encoding a C4 dicarboxylic acid transporter, a heterologous second polynucleotide encoding a malate dehydrogenase, and a heterologous third polynucleotide encoding a pyruvate carboxylase; wherein the filamentous fungal host cell is capable of secreting increased levels of the C4 dicarboxylic acid compared to the filamentous fungal host cell without the heterologous polynucleotide when cultivated under the same conditions; and (b) recovering the C4 dicarboxylic acid. The present invention also relates to methods for increasing C4 dicarboxylic acid production, filamentous fungal host cells and malate dehydrogenase variants. | 08-21-2014 |
20150024446 | Methods for improving malic acid production in filamentous fungi - The present invention relates to methods of producing a C4 dicarboxylic acid, comprising: (a) cultivating a filamentous fungal host cell comprising a polynucleotide selected from the group consisting of a heterologous first polynucleotide encoding a C4 dicarboxylic acid transporter, a heterologous second polynucleotide encoding a malate dehydrogenase, and a heterologous third polynucleotide encoding a pyruvate carboxylase; wherein the filamentous fungal host cell is capable of secreting increased levels of the C4 dicarboxylic acid compared to the filamentous fungal host cell without the heterologous polynucleotide when cultivated under the same conditions; and (b) recovering the C4 dicarboxylic acid. The present invention also relates to methods for increasing C4 dicarboxylic acid production, filamentous fungal host cells and malate dehydrogenase variants. | 01-22-2015 |
Sheryl Martin-Moe, Alameda, CA US
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20130236448 | CONCENTRATED POLYPEPTIDE FORMULATIONS WITH REDUCED VISCOSITY - The present invention relates to polypeptide formulations with reduced viscosity and methods of making and using polypeptide formulations with reduced viscosity. | 09-12-2013 |
Sheryl Skaalerud, Leslieville CA
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20140147274 | FLUID APPARATUS WITH PITCH ADJUSTABLE VANES - An apparatus comprising: a frame; a shaft mounted to the frame for rotation; plural vanes each mounted for rotation about a respective pitch adjustment axis on one or more respective arms extending from the shaft; a collar mounted to the frame coaxial with the shaft, the collar having a first outer circumferential surface defining a convex cam shape, and a second outer circumferential surface defining a non cam circular shape; and plural followers arranged to contact the first outer circumferential surface in a first configuration corresponding to a first speed of rotation of the shaft and the second outer circumferential surface in a second configuration corresponding to a second speed of rotation of the shaft, the second speed being higher than the first speed, the plural followers being each connected to adjust the pitch of a respective vane of the plural vanes. | 05-29-2014 |
Sheryl Skaalerud US
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20140147274 | FLUID APPARATUS WITH PITCH ADJUSTABLE VANES - An apparatus comprising: a frame; a shaft mounted to the frame for rotation; plural vanes each mounted for rotation about a respective pitch adjustment axis on one or more respective arms extending from the shaft; a collar mounted to the frame coaxial with the shaft, the collar having a first outer circumferential surface defining a convex cam shape, and a second outer circumferential surface defining a non cam circular shape; and plural followers arranged to contact the first outer circumferential surface in a first configuration corresponding to a first speed of rotation of the shaft and the second outer circumferential surface in a second configuration corresponding to a second speed of rotation of the shaft, the second speed being higher than the first speed, the plural followers being each connected to adjust the pitch of a respective vane of the plural vanes. | 05-29-2014 |
Sheryl Sleeva, Norwalk, CT US
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20090192876 | METHODS AND SYSTEMS FOR PROVIDING A PAYMENT CARD PROGRAM DIRECTED TO EMPTY NESTERS - A computer-based method for enrolling financial transaction cardholders into a payment card program that includes features that are directed to an empty nester segment of society is described. The method includes creating at least one spending profile representing an empty nester target group. The empty nester target group includes transaction cardholders within the empty nester segment of society targeted for receiving a marketing campaign. The method also includes storing in the database transaction data for transaction card accounts, identifying cardholders included within the empty nester target group by comparing the transaction data to the at least one empty nester spending profile, and offering a payment card program having at least one rewards feature directed to the empty nester segment of society to the cardholders identified as being within the empty nester target group. | 07-30-2009 |
20110106607 | Techniques For Targeted Offers - Systems and methods for analyzing and segregating payment card account profiles into clusters and targeting offers to cardholders. Offers may be targeted based on analyzing customer transactions with merchants from a merchant category as compared with transactions with merchants from a universe of merchants. Customers who have no transaction history with a merchant may be selected for offers based on similarities with respect to other customers of the merchant. Multiple merchant offers may be combined into a single mailing based on a scoring algorithm. | 05-05-2011 |
Sheryl Smith, Alantic Beach, NY US
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20090269795 | Mutant alpha4betadelta GABAA receptor and methods of treating anxiety or irritability - The present invention provides methods for treating anxiety or irritability in a subject. The methods comprise administering to the subject an effective amount of an antagonist of allopregnanolone (THP), or a regulator which decreases expression of the alpha 4 subunit of GABA such as gabadoxbol (THIP), or a vector comprising an isolated nucleic acid molecule encoding a mutant alpha 4 subunit GABA | 10-29-2009 |
Sheryl Thingvold, Toronto, On CA
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20160070436 | PLANNING, NAVIGATION AND SIMULATION SYSTEMS AND METHODS FOR MINIMALLY INVASIVE THERAPY - Disclosed herein are planning, navigation and simulation systems and methods for minimally invasive therapy in which the planning method and system uses patient specific pre-operative images. The planning system allows for multiple paths to be developed from the pre-operative images, and scores the paths depending on desired surgical outcome of the surgery and the navigation systems allow for minimally invasive port based surgical procedures, as well as craniotomies in the particular case of brain surgery. | 03-10-2016 |