Patent application number | Description | Published |
20090209434 | Probe-antiprobe compositions and methods for DNA or RNA detection - The invention provides novel compositions and methods for detecting unlabeled nucleic acid targets using labeled polynucleotide probes and partially complementary antiprobes. The interaction of probes, antiprobes and targets result in signaling changes that indicate target frequency. This novel detection mechanism is called a DNA detection switch, and it enable end-point detection, microarray detection and real-time PCR detection of a variety of nucleic acid targets including microbial species and subspecies, drug resistant mutants, and pathogenic strains. | 08-20-2009 |
20090239769 | Expression Miniarrays and Uses Thereof - The present invention provides methods and devices for making new and inexpensive miniarrays suitable for gene expression analysis. Also provided herein are methods of diagnosis for specific tissue or condition using specialized diagnostic miniarrays that exhibit specific visual pattern as diagnostic readout. | 09-24-2009 |
20090275029 | Systems and Methods to Quantify and Amplify Both Signaling and Probes for CDNA Chips and Gene Expression Microarrays - The invention provides a series of reagent compositions and methods for making and amplifying novel cDNA based probe sets from RNA samples to improve analysis with gene expression arrays. The methods globally produce probe sets with common universal linkers at one or both ends, called WRAP-Probes, wherein the linkers do not bind to the target sequences and they can efficiently bind added reporters to the probes. The universal linkers are also designed as primer binding sites for copying and amplifying the probes, either linearly with one linker, or exponentially with double linkers. The capacity to globally and exponentially amplify the probe set by PCR is a primary advantage. Adding reporters by terminal linkers also improves quantification since each probe gets equivalent signaling. The invention allows expression analysis of small research, clinical and forensic samples to enable improved diagnostics, drug discovery, therapeutic monitoring, and medical, agricultural and general research. | 11-05-2009 |
20120058474 | PROBE-ANTIPROBE COMPOSITIONS AND METHODS FOR DNA OR RNA DETECTION - The invention provides novel compositions and methods for detecting unlabeled nucleic acid targets using labeled polynucleotide probes and partially complementary antiprobes. The interaction of probes, antiprobes and targets result in signaling changes that indicate target frequency. This novel detection mechanism is called a DNA detection switch, and it enable end-point detection, microarray detection and real-time PCR detection of a variety of nucleic acid targets including microbial species and subspecies, drug resistant mutants, and pathogenic strains. | 03-08-2012 |
20120157343 | System and Methods to Quantify and Amplify Both Signaling and Probes for cDNA Chips and Gene Expression Microarrays - The invention provides a series of reagent compositions and methods for making and amplifying novel cDNA based probe sets from RNA samples to improve analysis with gene expression arrays. The methods globally produce probe sets with common universal linkers at one or both ends, called WRAP-Probes, wherein the linkers do not bind to the target sequences and they can efficiently bind added reporters to the probes. The universal linkers are also designed as primer binding sites for copying and amplifying the probes, either linearly with one linker, or exponentially with double linkers. The capacity to globally and exponentially amplify the probe set by PCR is a primary advantage. Adding reporters by terminal linkers also improves quantification since each probe gets equivalent signaling. The invention allows expression analysis of small research, clinical and forensic samples to enable improved diagnostics, drug discovery, therapeutic monitoring, and medical, agricultural and general research. | 06-21-2012 |
20140287410 | Probe:Antiprobe Compositions for High Specificity DNA or RNA Detection - Probe systems and methods are provided for detecting nucleic acid targets using labeled polynucleotide probes and antiprobes that interact together and with complementary targets. These interactions result in signaling changes that indicate target frequency and provide error-checking functions that facilitate single base discrimination. These probe:antiprobe compositions enable real-time PCR detection, end-point detection and microarray detection of microbial species, drug resistant mutants, and cancer related variants. The probe:antiprobe may be an internal probe between two primers or may be a primer-probe. The probe also may be modified by introducing a base mismatch to increase thermodynamic discrimination of a correct versus incorrect target differing by a single base. Probe systems also are provided for use in methods of increasing target amplification and detecting specific single base variants. | 09-25-2014 |
Patent application number | Description | Published |
20080247035 | Catadioptric imaging system employing immersion liquid for use in broad band microscopy - A reduced size catadioptric inspection system employing a catadioptric objective and immersion substance is disclosed. The objective may be employed with light energy having a wavelength in the range of approximately 190 nanometers through the infrared light range, and can provide numerical apertures in excess of 0.9. Elements are less than 100 millimeters in diameter and may fit within a standard microscope. The objective comprises a focusing lens group, a field lens, a Mangin mirror arrangement, and an immersion substance or liquid between the Mangin mirror arrangement and the specimen. A variable focal length optical system for use with the objective in the catadioptric inspection system is also disclosed. | 10-09-2008 |
20080316456 | CATADIOPTRIC PROJECTION OBJECTIVE WITH GEOMETRIC BEAM SPLITTING - A projection exposure lens has an object plane, optical elements for separating beams, a concave mirror, an image plane, a first lens system arranged between the object plane and the optical elements for separating beams, a second double pass lens system arranged between the optical elements for separating beams and the concave mirror, a third lens system arranged between the optical elements for separating beams and the image plane. The second lens system has a maximum of five lenses. | 12-25-2008 |
20090080086 | SYMMETRICAL OBJECTIVE HAVING FOUR LENS GROUPS FOR MICROLITHOGRAPHY - The invention features a system for microlithography that includes a mercury light source configured to emit radiation at multiple mercury emission lines, a projection objective positioned to receive radiation emitted by the mercury light source, and a stage configured to position a wafer relative to the projection objective. During operation, the projection objective directs radiation from the light source to the wafer, where the radiation at the wafer includes energy from more than one of the emission lines. Optical lens systems for use in said projection objective comprise four lens groups, each having two lenses comprising silica, the first and second lens groups on one hand and the third and fourth lens groups on the other hand are positioned symmetrically with respect to a plane perpendicular to the optical axis of said lens system. | 03-26-2009 |
20110116077 | EUV High Throughput Inspection System For Defect Detection On Patterned EUV Masks, Mask Blanks, And Wafers - Inspection of EUV patterned masks, blank masks, and patterned wafers generated by EUV patterned masks requires high magnification and a large field of view at the image plane. An EUV inspection system can include a light source directed to an inspected surface, a detector for detecting light deflected from the inspected surface, and an optic configuration for directing the light from the inspected surface to the detector. In particular, the detector can include a plurality of sensor modules. Additionally, the optic configuration can include a plurality of mirrors that provide magnification of at least 100× within an optical path less than 5 meters long. In one embodiment, the optical path is approximately 2-3 meters long. | 05-19-2011 |
20120069312 | IMAGING OPTICAL SYSTEM AND PROJECTION EXPOSURE INSTALLATION FOR MICROLITHOGRAPHY WITH AN IMAGING OPTICAL SYSTEM OF THIS TYPE - An imaging optical system has a plurality of mirrors which image an object field in an object plane in an image field in an image plane. The imaging optical system has a pupil obscuration. The last mirror in the beam path of the imaging light between the object field and the image field has a through-opening for the passage of the imaging light. A penultimate mirror of the imaging optical system in the beam path of the imaging light between the object field and the image field has no through-opening for the passage of the imaging light. The result is an imaging optical system that provides a combination of small imaging errors, manageable production and a good throughput for the imaging light. | 03-22-2012 |
20130120728 | CATADIOPTRIC PROJECTION OBJECTIVE WITH MIRROR GROUP - A catadioptric projection objective for imaging an off-axis object field arranged in an object surface of the projection objective onto an off-axis image field arranged in an image surface of the projection objective has a front lens group, a mirror group comprising four mirrors and having an object side mirror group entry, an image side mirror group exit, and a mirror group plane aligned transversely to the optical axis and arranged geometrically between the mirror group entry and the mirror group exit; and a rear lens group. | 05-16-2013 |
20140001370 | EUV High Throughput Inspection System For Defect Detection On Patterned EUV Masks, Mask Blanks, And Wafers | 01-02-2014 |
20140111787 | CATADIOPTRIC PROJECTION OBJECTIVE - A catadioptric projection objective for imaging a pattern provided in an object plane of the projection objective onto an image plane of the projection objective has a first, refractive objective part for imaging the pattern provided in the object plane into a first intermediate image; a second objective part including at least one concave mirror for imaging the first Intermediate imaging into a second intermediate image; and a third, refractive objective part for imaging the second intermediate imaging onto the image plane; wherein the projection objective has a maximum lens diameter D | 04-24-2014 |
20140217299 | EUV High Throughput Inspection System For Defect Detection On Patterned EUV Masks, Mask Blanks, And Wafers - Inspection of EUV patterned masks, blank masks, and patterned wafers generated by EUV patterned masks requires high magnification and a large field of view at the image plane. An EUV inspection system can include a light source directed to an inspected surface, a detector for detecting light deflected from the inspected surface, and an optic configuration for directing the light from the inspected surface to the detector. In particular, the detector can include a plurality of sensor modules. Additionally, the optic configuration can include a plurality of mirrors that provide magnification of at least 100× within an optical path less than 5 meters long. In one embodiment, the optical path is approximately 2-3 meters long. | 08-07-2014 |
20150055214 | CATADIOPTRIC PROJECTION OBJECTIVE - A catadioptric projection objective for imaging a pattern provided in an object plane of the projection objective onto an image plane of the projection objective has a first, refractive objective part for imaging the pattern provided in the object plane into a first intermediate image; a second objective part including at least one concave mirror for imaging the first Intermediate imaging into a second intermediate image; and a third, refractive objective part for imaging the second intermediate imaging onto the image plane; wherein the projection objective has a maximum lens diameter D | 02-26-2015 |
Patent application number | Description | Published |
20080206351 | Malodor Reduction of Cosmetic Products - Malodor free skin care compositions are described. The skin care compositions comprise an adsorbable solvent and an insoluble particle in an adsorbable solvent-insoluble particle complex. The complex is suitable to adsorb components with malodor to yield a skin care composition free of offensive odors like those generated from the oxidation of conjugated linoleic acid. | 08-28-2008 |
20100062961 | Good Foaming Creamy or Paste-Like Cleansers Comprising Floor Levels of Long Chain Lipids or Lipid Mimics - The present invention relates to compositions, especially pastes/creams which have high level of long chain lipids or lipid mimics. These help provide “creaminess”, a desirable rheological characteristic. This is seen from defined viscosity values which define the pastes. In addition, unpredictably, when used in combination with short chain phase inducers, foam values are adequate when it would be expected the lipids would decrease foam. The composition also retains stability from physical separation. | 03-11-2010 |
20110143984 | METHOD OF ENHANCING PERFUME BLOOM IN EXTRUDED DILUTED BARS HAVING LOW TOTAL FATTY MATTER AND USING STARCH POLYOL STRUCTURING SYSTEM - The present invention relates to a method of obtaining enhanced perfume bloom, e.g., bars providing enhanced perfume impact. By selecting specific bar compositions (e.g., with low TFM and specific starch-polyol structuring system), it has been unexpectedly found that bloom is actually increased upon dilution of such bars. | 06-16-2011 |
20110143985 | METHOD OF ENHANCING PERFUME RETENTION DURING STORAGE USING LOW TOTAL FATTY MATTER EXTRUDED BARS HAVING STARCH POLYOL STRUCTURING SYSTEM - The present invention relates to a method of enhanced perfume retention, e.g., bars providing enhanced retention. By selecting specific bar compositions (e.g., with low TFM and specific starch-polyol structuring system), it has been unexpectedly found that retention of perfume during dry bar storage is actually increased. | 06-16-2011 |
20120040003 | ANTI-DANDRUFF COMPOSITIONS WITH CITRUS FIBERS - A shampoo composition is described which includes from 1 to 25% by weight of mild surfactants, from 0.001 to 5% by weight of citrus fibers, from 0.01 to 5% by weight of anti-dandruff zinc salts, and a cosmetically acceptable carrier. The citrus fibers help structure the composition to maintain phase stability, provide appropriate viscosity and achieve deposition of the anti-dandruff zinc salts. | 02-16-2012 |
Patent application number | Description | Published |
20110051892 | RADIATION THERAPY SKIN MARKER - Radiation therapy skin markers used to delineate radiation therapy portal areas of a patient to be treated with radiation are described. The radiation therapy skin marker includes comprises a substrate having a first surface and a second surface. The first surface of the substrate is lined with an ink to facilitate the outlining of the treatment field. The second surface is coated with an adhesive layer which is protected by release liner. | 03-03-2011 |
20110086114 | NASAL COMPOSITION - A nasal spray solution for use as a nasal spray and methods of using the solution are disclosed. The nasal spray solution moisturizes nasal passages and alleviates nasal dryness. The solution includes a hypotonic saline solution, wherein the saline solution is hypotonic with respect to cells of the nasal mucosa of the nasal passages, a buffering agent, a lubricating agent, and an anti-microbial agent. | 04-14-2011 |
20120033786 | MAMMOGRAPHY PAD - A mammography pad for use with a mammography unit for providing comfort to a patient during a mammography examination. The mammography pad includes a flexible substrate configured to overlie a bucky plate, a compressible material and a fastening means. The mammography pad is capable of covering a top and front surface of the compression plate, while the fastening means removably attaches a portion of the mammography pad to the mammography unit. Further, a method for administering a mammography examination with the mammography pad is disclosed by providing a mammography pad, securing the pad to the mammography unit, placing a patient's breast on the mammography pad, and compressing the patient's breast against the mammography pad. | 02-09-2012 |
20130134059 | PACKAGING FOR RETRO-REFLECTIVE MARKERS - Described is a device comprising a retro-reflective marker sphere comprising: a core ball comprising: a generally spherical body portion, a mounting base extending from one end of the body portion of the core ball, and a mounting recess having a recess opening in the mounting base and extending into the body portion of the core ball, and a retro-reflective covering on the core ball, the retro-reflective covering comprising an opening through which the mounting base of the core ball extends, wherein a flat lower surface of the mounting base is spaced proximally from a lower edge of the opening of the retro-reflective covering, and wherein the mounting recess includes an interior screw thread for engaging an exterior screw thread of a mounting post when the retro-reflective marker sphere is mounted on the mounting post. | 05-30-2013 |
20130135730 | RETRO-REFLECTIVE MARKER INCLUDING COLORED MOUNTING PORTION - Described is a device comprising a retro-reflective marker sphere comprising: a core ball comprising: a generally spherical body portion, a mounting base extending from one end of the body portion of the core ball, and a mounting recess having a recess opening in the mounting base and extending into the body portion of the core ball, and a retro-reflective covering on the core ball, the retro-reflective covering comprising an opening through which the mounting base of the core ball extends, wherein a flat lower surface of the mounting base is spaced proximally from a lower edge of the opening of the retro-reflective covering, and wherein the mounting recess includes an interior screw thread for engaging an exterior screw thread of a mounting post when the retro-reflective marker sphere is mounted on the mounting post. | 05-30-2013 |
20130135732 | RADIOPAQUE CORE - Described is a device comprising a retro-reflective marker sphere comprising: a core ball comprising: a generally spherical body portion, a mounting base extending from one end of the body portion of the core ball, and a mounting recess having a recess opening in the mounting base and extending into the body portion of the core ball, and a retro-reflective covering on the core ball, the retro-reflective covering comprising an opening through which the mounting base of the core ball extends, wherein a flat lower surface of the mounting base is spaced proximally from a lower edge of the opening of the retro-reflective covering, and wherein the mounting recess includes an interior screw thread for engaging an exterior screw thread of a mounting post when the retro-reflective marker sphere is mounted on the mounting post. | 05-30-2013 |
20130135733 | MATERIAL THICKNESS CONTROL OVER RETRO-REFLECTIVE MARKER - Described is a device comprising a retro-reflective marker sphere comprising: a core ball comprising: a generally spherical body portion, a mounting base extending from one end of the body portion of the core ball, and a mounting recess having a recess opening in the mounting base and extending into the body portion of the core ball, and a retro-reflective covering on the core ball, the retro-reflective covering comprising an opening through which the mounting base of the core ball extends, wherein a flat lower surface of the mounting base is spaced proximally from a lower edge of the opening of the retro-reflective covering, and wherein the mounting recess includes an interior screw thread for engaging an exterior screw thread of a mounting post when the retro-reflective marker sphere is mounted on the mounting post. | 05-30-2013 |
20130135734 | HIGH REFLECTIVITY RETRO-REFLECTIVE MARKER - Described is a device comprising a retro-reflective marker sphere comprising: a core ball comprising: a generally spherical body portion, a mounting base extending from one end of the body portion of the core ball, and a mounting recess having a recess opening in the mounting base and extending into the body portion of the core ball, and a retro-reflective covering on the core ball, the retro-reflective covering comprising an opening through which the mounting base of the core ball extends, wherein a flat lower surface of the mounting base is spaced proximally from a lower edge of the opening of the retro-reflective covering, and wherein the mounting recess includes an interior screw thread for engaging an exterior screw thread of a mounting post when the retro-reflective marker sphere is mounted on the mounting post. | 05-30-2013 |
20130135735 | REFLECTIVE MARKER BEING RADIO-OPAQUE FOR MRI - Described is a device comprising a retro-reflective marker sphere comprising: a core ball comprising: a generally spherical body portion, a mounting base extending from one end of the body portion of the core ball, and a mounting recess having a recess opening in the mounting base and extending into the body portion of the core ball, and a retro-reflective covering on the core ball, the retro-reflective covering comprising an opening through which the mounting base of the core ball extends, wherein a flat lower surface of the mounting base is spaced proximally from a lower edge of the opening of the retro-reflective covering, and wherein the mounting recess includes an interior screw thread for engaging an exterior screw thread of a mounting post when the retro-reflective marker sphere is mounted on the mounting post. | 05-30-2013 |
20130135736 | REFLECTIVE MARKER WITH ALIGNMENT FEATURE - Described is a device comprising a retro-reflective marker sphere comprising: a core ball comprising: a generally spherical body portion, a mounting base extending from one end of the body portion of the core ball, and a mounting recess having a recess opening in the mounting base and extending into the body portion of the core ball, and a retro-reflective covering on the core ball, the retro-reflective covering comprising an opening through which the mounting base of the core ball extends, wherein a flat lower surface of the mounting base is spaced proximally from a lower edge of the opening of the retro-reflective covering, and wherein the mounting recess includes an interior screw thread for engaging an exterior screw thread of a mounting post when the retro-reflective marker sphere is mounted on the mounting post. | 05-30-2013 |
20130135737 | MARKER SPHERE INCLUDING EDGED OPENING TO AID IN MOLDING - Described is a device comprising a retro-reflective marker sphere comprising: a core ball comprising: a generally spherical body portion, a mounting base extending from one end of the body portion of the core ball, and a mounting recess having a recess opening in the mounting base and extending into the body portion of the core ball, and a retro-reflective covering on the core ball, the retro-reflective covering comprising an opening through which the mounting base of the core ball extends, wherein a flat lower surface of the mounting base is spaced proximally from a lower edge of the opening of the retro-reflective covering, and wherein the mounting recess includes an interior screw thread for engaging an exterior screw thread of a mounting post when the retro-reflective marker sphere is mounted on the mounting post. | 05-30-2013 |
20130135738 | RETRO-REFLECTIVE MARKER WITH SNAP ON THREADED POST - Described is a device comprising a retro-reflective marker sphere comprising: a core ball comprising: a generally spherical body portion, a mounting base extending from one end of the body portion of the core ball, and a mounting recess having a recess opening in the mounting base and extending into the body portion of the core ball, and a retro-reflective covering on the core ball, the retro-reflective covering comprising an opening through which the mounting base of the core ball extends, wherein a flat lower surface of the mounting base is spaced proximally from a lower edge of the opening of the retro-reflective covering, and wherein the mounting recess includes an interior screw thread for engaging an exterior screw thread of a mounting post when the retro-reflective marker sphere is mounted on the mounting post. | 05-30-2013 |
20130219601 | PROTECTIVE COVER FOR MEDICAL DEVICE HAVING ADHESIVE MECHANISM - A protective liner is described comprising a collar having a main collar portion, a first extension emanating from the main collar portion in a first direction, a second extension emanating from the main collar portion in a second direction opposite to the first direction. Disclosed embodiments may include a chest portion extending from the main collar portion. The protective liner may also include an adjustable releasable fastener for joining the first extension to the second extension. The adjustable releasable fastener may be disposed upon at least one of the first extension and second extension, wherein a material of the protective liner comprises a non-woven, fluid repellent material. | 08-29-2013 |
20130220342 | PROTECTIVE COVER FOR MEDICAL DEVICE HAVING A RADIATION DETECTOR - A protective liner is described comprising a collar having a main collar portion, a first extension emanating from the main collar portion in a first direction, a second extension emanating from the main collar portion in a second direction opposite to the first direction. Disclosed embodiments may include a chest portion extending from the main collar portion. The protective liner may also include an adjustable releasable fastener for joining the first extension to the second extension. The adjustable releasable fastener may be disposed upon at least one of the first extension and second extension, wherein a material of the protective liner comprises a non-woven, fluid repellent material. | 08-29-2013 |
20130220344 | PROTECTIVE COVER FOR MEDICAL DEVICE - A protective liner is described comprising a collar having a main collar portion, a first extension emanating from the main collar portion in a first direction, a second extension emanating from the main collar portion in a second direction opposite to the first direction. Disclosed embodiments may include a chest portion extending from the main collar portion. The protective liner may also include an adjustable releasable fastener for joining the first extension to the second extension. The adjustable releasable fastener may be disposed upon at least one of the first extension and second extension, wherein a material of the protective liner comprises a non-woven, fluid repellent material. | 08-29-2013 |
Patent application number | Description | Published |
20090236281 | SYSTEM AND METHOD FOR TREATING PRODUCED WATER - Systems and methods have been developed for treating the waste water contaminated with methanol and boron in addition to other contaminants. The systems and methods allow specifically for the removal of the methanol and boron without the addition of significant chemicals to raise the pH. The water is treated by removing the methanol via biological digestion in a bioreactor, separating a majority of the contaminants from the water by reverse osmosis and removing the boron that passes through the reverse osmosis system with a boron-removing ion exchange resin. | 09-24-2009 |
20100038310 | Waste Water Treatment Method - Systems and methods have been developed for reclaiming water contaminated with the expected range of contaminants typically associated with produced water, including water contaminated with slick water, methanol and boron. The system includes anaerobically digesting the contaminated water, followed by aerating the water to enhance biological digestion. After aeration, the water is separated using a flotation operation that effectively removes the spent friction reducing agents and allows the treated water to be reclaimed and reused as fracturing water, even though it retains levels of contaminants, including boron and methanol, that would prevent its discharge to the environment under existing standards. The treated water may further be treated by removing the methanol via biological digestion in a bioreactor, separating a majority of the contaminants from the water by reverse osmosis and removing the boron that passes through the reverse osmosis system with a boron-removing ion exchange resin. | 02-18-2010 |
20100224557 | METHOD OF OPERATING A BIOREACTOR AND FILTRATION SYSTEM - The disclosure describes a novel method for operating a bioreactor and filtration system. The method adds excess iron to the bioreactor to improve the overall operation and efficiency of the bioreactor/filtration system. | 09-09-2010 |
20100224564 | METHOD FOR REMOVING ORGANIC CONTAMINANTS FROM RESINS - The disclosure describes a novel method for operating a resin treatment system and a novel organic polisher. The method for operating the resin treatment system is efficient and cost effective. | 09-09-2010 |
20120152830 | WASTE WATER TREATMENT METHOD - Systems and methods have been developed for reclaiming water contaminated with the expected range of contaminants typically associated with produced water, including water contaminated with slick water, methanol and boron. The system includes anaerobically digesting the contaminated water, followed by aerating the water to enhance biological digestion. After aeration, the water is separated using a flotation operation that effectively removes the spent friction reducing agents and allows the treated water to be reclaimed and reused as fracturing water, even though it retains levels of contaminants, including boron and methanol, that would prevent its discharge to the environment under existing standards. The treated water may further be treated by removing the methanol via biological digestion in a bioreactor, separating a majority of the contaminants from the water by reverse osmosis and removing the boron that passes through the reverse osmosis system with a boron-removing ion exchange resin. | 06-21-2012 |
20130330128 | WASTE WATER TREATMENT METHOD - Systems and methods have been developed for reclaiming water contaminated with the expected range of contaminants typically associated with produced water, including water contaminated with slick water, methanol and boron. The system includes anaerobically digesting the contaminated water, followed by aerating the water to enhance biological digestion. After aeration, the water is separated using a flotation operation that effectively removes the spent friction reducing agents and allows the treated water to be reclaimed and reused as fracturing water, even though it retains levels of contaminants, including boron and methanol, that would prevent its discharge to the environment under existing standards. The treated water may further be treated by removing the methanol via biological digestion in a bioreactor, separating a majority of the contaminants from the water by reverse osmosis and removing the boron that passes through the reverse osmosis system with a boron-removing ion exchange resin. | 12-12-2013 |
Patent application number | Description | Published |
20090214612 | EXTRACELLULAR TNF INHIBITORS FOR TREATING CNS DISORDERS - Methods and devices to attenuate tumor necrosis factor (TNF) and other pro-inflammatory mediators in the CNS to treat neurological, neurodegenerative, neuropsychiatric disorders, and brain injury are described. More particularly, TNF blocking agents that target TNF-receptor interactions and the effects of downstream secreted cytokines associated with an inflammatory cascade are described. Such TNF blocking agents are administered directly to the brain by, for example, intraparenchymal administration, intracerebroventricular administration, or administration into a cerebral artery. Devices described include therapy delivery devices comprising a reservoir capable of housing a TNF blocking agent and a catheter operably coupled to the device and adapted to deliver the TNF blocking agent to a target site within a subject. | 08-27-2009 |
20100159015 | Systems and Methods to Treat Pain Locally - Disclosed herein are systems and methods for contributing to the local treatment of pain. More specifically, the disclosed systems and methods contribute to the local treatment pain by inhibiting the NFκB family of transcription factors. | 06-24-2010 |
20110033463 | APHERESIS, ADMINISTRATION OF AGENT, OR COMBINATION THEREOF - A device is configured to remove a target molecule from a bodily fluid of a subject and to deliver a therapeutic agent to the subject. Such a device may be used for treatment of a disease associated with amyloid beta accumulation in the subject. Agents selected from the group consisting of an ApoE-modulating agent; a RAGE inhibitor; a β-secretase 1 (BACE1) inhibitor; a γ-secretase inhibitor; a muscarinic receptor subtype 1 (M1) agonists; a growth factor; an enzyme capable of degrading amyloid beta; a mitochondrial antioxidant; insulin; and an inhibitor of tumor necrosis factor (TNF) may be administered directly to the central nervous system of a subject for treatment of a disease associated with amyloid beta accumulation. | 02-10-2011 |
20110202000 | ANTI-AMYLOID BETA ANTIBODIES CONJUGATED TO SIALIC ACID-CONTAINING MOLECULES - Antibody complexes including anti-Aβ antibodies conjugated with a sialic acid-containing molecule show improved bioavailability with no significant adverse effects on binding to amyloid beta. | 08-18-2011 |
20120087869 | METHODS FOR DISTRIBUTING AGENTS TO AREAS OF BRAIN - Broad cerebrospinal fluid (CSF) distribution of an agent is achievable by delivering the agent in a liquid formulation to the CSF at flow rates less than 500 microliters per hour, such as between about 2 microliters per hour and about 100 microliters per hour. | 04-12-2012 |
20120143272 | METHOD FOR TREATING DAMAGED TISSUE OF THE CNS - Devices and methods for treating diseases associated with loss of neuronal function are described. The methods are designed to promote proliferation, differentiation, migration, or integration of endogenous progenitor stem cells of the central nervous system (CNS). A therapy, such as an electrical signal or a stem cell enhancing agent, or a combination of therapies, is applied to a CNS region containing endogenous stem cells or a CNS region where the endogenous stem cells are predicted to migrate and eventually reside, or a combination thereof. | 06-07-2012 |
Patent application number | Description | Published |
20080286330 | METHODS AND DEVICE TO NEUTRALIZE SOLUBLE TOXIC AGENTS IN THE BRAIN - Methods, agents and devices for treating a patient to reduce accumulation of certain proteins in the brain are described. Such proteins include Aβ, and the methods, agents and devices are useful for reducing the accumulation of Aβ, which is a principal constituent of the plaques associated with such diseases as Alzheimer's disease (AD). Antibodies to Aβ, when delivered systemically or directly into the central nervous system, improve cognitive deficits in a transgenic mouse model of AD. However, unlike peripheral of antibodies to Aβ, which increased cerebral vascular plaques and hemorrhages, direct central administration did not result in such an increase cerebral vascular plaques and hemorrhages. | 11-20-2008 |
20090175923 | HUMANIZED ANTI-AMYLOID BETA ANTIBODIES - Humanized anti-Aβ antibodies derived from a murine antibody directed to a N-terminal epitope of Aβ are described. The humanized antibodies have reduced or no human T cell epitopes and bind Aβ with an affinity similar to that of the murine antibody. | 07-09-2009 |
20100030196 | APHERESIS OF A TARGET MOLECULE FROM CEREBROSPINAL FLUID - A system includes (i) a medium having a solid support to which an antibody directed to target molecule is bound, (ii) a reservoir for containing the medium, (iii) a first catheter, and (iv) a second catheter. The first catheter has a proximal end portion, an opening for removal of cerebrospinal fluid from a subject, and a lumen extending from the proximal end portion to the opening. The first catheter is operably couplable to the reservoir such that fluid is capable of flowing from the lumen to the reservoir. The second catheter has a proximal end portion, a delivery region for returning cerebrospinal fluid to the subject, and a lumen extending from the proximal end portion to the delivery region. The second catheter is operably couplable to the reservoir such that fluid is capable of flowing from the reservoir to the lumen. | 02-04-2010 |
20110177076 | HUMANIZED ANTI-AMYLOID BETA ANTIBODIES - Humanized anti-Aβ antibodies derived from a murine antibody directed to a N-terminal epitope of Aβ are described. The humanized antibodies have reduced or no human T cell epitopes and bind Aβ with an affinity similar to that of the murine antibody. | 07-21-2011 |
Patent application number | Description | Published |
20110303849 | DUAL SCREEN RADIOGRAPHIC DETECTOR WITH IMPROVED SPATIAL SAMPLING - Embodiments of radiographic imaging apparatus and methods for operating the same can include a first scintillator, a second scintillator, a plurality of first photosensitive elements, and a plurality of second photosensitive elements. The plurality of first photosensitive elements receives light from the first scintillator and has first photosensitive element characteristics chosen to cooperate with the first scintillator properties. The plurality of second photosensitive elements are arranged to receive light from the second scintillator and has second photosensitive element characteristics different from the first photosensitive element characteristics and chosen to cooperate with the second scintillator properties. Further, the first scintillator can have first scintillator properties and the second scintillator can have second scintillator properties different from the first scintillator properties. | 12-15-2011 |
20130001426 | RADIOGRAPHIC DETECTOR INCLUDING TRAP OCCUPANCY CHANGE MONITOR AND FEEDBACK, IMAGING APPARATUS AND METHODS USING THE SAME - Embodiments of radiographic imaging systems; digital radiography detectors and methods for using the same can monitor and/or control trap occupancy levels in photosensors of radiographic sensors (e.g., DR FPDs). In exemplary radiographic imaging apparatus embodiments, monitoring of trap occupancy or change in trap occupancy of the photosensor can determine whether an imaging array or detector panel has reached a stable operating point. In another embodiment, trap occupancy information can be used (a) to enable a generator (e.g., x-ray source) for a radiographic exposure and/or (b) to adjust to or to maintain a change in trap occupancy level at pre-determined set-point or to adjust to or maintain a change in trap occupancy level within a prescribed range (e.g., using clock signals and bias voltages applied to the photosensor). | 01-03-2013 |
20130259194 | HYBRID SLOT-SCANNING GRATING-BASED DIFFERENTIAL PHASE CONTRAST IMAGING SYSTEM FOR MEDICAL RADIOGRAPHIC IMAGING - Embodiments of methods and apparatus are disclosed for obtaining a phase-contrast digital mammography system and methods for same that can include an x-ray source for radiographic imaging; a beam shaping assembly including a filter or a tunable monochromator, a collimator, a source grating, an x-ray grating interferometer including a phase grating, and an analyzer grating; and an x-ray detector; where the source grating, the phase grating, and the analyzer grating are aligned in such a way that the grating bars of these gratings are parallel to each other. | 10-03-2013 |
20140177789 | GRATING-BASED DIFFERENTIAL PHASE CONTRAST IMAGING SYSTEM WITH ADJUSTABLE CAPTURE TECHNIQUE FOR MEDICAL RADIOGRAPHIC IMAGING - Embodiments of methods and apparatus are disclosed for obtaining a phase-contrast digital radiographic imaging system and methods for same that can include an x-ray source for radiographic imaging; a beam shaping assembly including a collimator and a source grating, an x-ray grating interferometer including a phase grating, and an analyzer grating; and an x-ray detector, where the phase-contrast digital radiographic imaging system and methods are adjustable for different mean energies of the x-ray source. | 06-26-2014 |
20140185746 | SPECTRAL GRATING-BASED DIFFERENTIAL PHASE CONTRAST SYSTEM FOR MEDICAL RADIOGRAPHIC IMAGING - Embodiments of methods and apparatus are disclosed for obtaining a phase-contrast digital radiographic imaging system and methods for same that can include an x-ray source for radiographic imaging; a beam shaping assembly including a collimator and a source grating, an x-ray grating interferometer including a phase grating, and an analyzer grating; and an x-ray detector, where a single arrangement of the beam shaping assembly, the x-ray grating interferometer and a position of the detector is configured to provide spectral information (e.g. at least two images obtained at different relative beam energies). | 07-03-2014 |
20140185896 | CONDITIONAL LIKELIHOOD MATERIAL DECOMPOSITION AND METHODS OF USING THE SAME - Embodiments of methods and apparatus are disclosed for obtaining a radiographic phase-contrast digital computed tomography imaging system and methods for same that can include obtaining a first and second plurality of 2D projection images over a range of scan angles, generating at least two statistically independent reconstructed images of an object from the first plurality of 2D projection images and the second plurality of 2D projection images, determining a material property as a function of volume for each of at least two materials represented in the projection images, using a conditional likelihood determination comprising the material property as a function of volume and the at least two statistically independent reconstructed images to differentiate the at least two materials in a reconstructed image of the object. | 07-03-2014 |
Patent application number | Description | Published |
20090048995 | EMBEDDED REACTIVE AND PROACTIVE INTELLIGENCE - A network device may include logic configured to invoke proactive programs based on the expiration of a long time period within the network device, wherein the proactive programs collect data relating to operations of the network device, invoke reactive programs based on the detection of at least one of an event or expiration of a short time period, wherein the reactive programs collect, correlate and analyze data relating to the detected event or expiration of a short time period, determine a corrective action based on collected and analyzed data, and perform the determined corrective action within the network device. | 02-19-2009 |
20090125633 | SERVER INITIATED SECURE NETWORK CONNECTION - In general, the invention is directed to techniques for establishing secure connections with devices residing behind a security device. In accordance with the techniques, a managed device initiates a transmission control protocol (TCP) session to establish a TCP session with a management device such that the management device acts as the TCP server and the managed device acts as a TCP client. Once established, the managed device sends a role reversal message specifying an identity of the managed device via the TCP session. Upon receiving the role reversal message, the management device initiates a secure connection over the TCP session in accordance with a secure protocol such that the management device acts as the secure protocol client and the managed device acts as the secure protocol server. By properly establishing the secure session, each of the devices assumes the proper roles and administrators may more easily configure the devices. | 05-14-2009 |
20110209203 | PROTECTING CONFIGURATION DATA IN A NETWORK DEVICE - Configuration information for a network device may be associated with a protection state that may restrict the modification of portions of the configuration information that are set to the protected state. The network device may be configured using configuration information defined as a group of hierarchically arranged configuration statements. Permissions may be stored for the network device relating to users permitted to modify the configuration information. The permissions may include permission tags, or other information defining the protection state, associated with the configuration statements. Intended modifications to the configuration information may be processed based on whether the intended modifications affect configuration statements associated with one of the permission tags. | 08-25-2011 |
20120303758 | IDENTIFYING SCRIPTING FORM OF TEXT COMMANDS FOR A NETWORK DEVICE - In one example, a device includes a network interface configured to present a command interface to receive input comprising a command and an indicator, wherein the command conforms to an execution format and specifies one or more parameters to be applied during execution of the command, and wherein the indicator indicates, at least in part, that the command is not to be executed, and a control unit configured to reformat, based on the indicator, the command to conform to an extensible markup language (XML) format such that the reformatted command complies with a syntax supported by a script processing module of the network device and specifies the command and the one or more parameters in the XML format in a format that can be executed by the script processing module, and to output the reformatted command via the command interface. Thus, the device may provide XML formatted equivalents for commands. | 11-29-2012 |
Patent application number | Description | Published |
20090058153 | ERGONOMIC CARRY HANDLE FOR JUVENILE VEHICLE SEAT - An infant carrier includes a shell and a carry handle coupled to the shell. The carry handle includes first and second side arms coupled to the shell. | 03-05-2009 |
20090066130 | LATCH BELT STORAGE SYSTEM FOR JUVENILE VEHICLE SEAT - A child restraint including a juvenile seat configured to be mounted on a seat base. The seat base includes a seat support and a LATCH system including first and second anchor belts for anchoring the seat support to the seat of a vehicle. The seat base includes a storage compartment for storing free ends of the anchor belts when the anchor belts are detached from the vehicle. | 03-12-2009 |
20100119292 | ADJUSTABLE TAB DIVIDER - Embodiments of the invention relate to dividers with tabs adjustable along at least two edges of the binder. One embodiment is directed to a divider for use in a binder. The divider comprises a panel, the panel comprising a binding edge and a plurality of non-binding edges, and a tab. The panel comprises at least one binding feature adjacent the binding edge and at least one tab mating feature adjacent at least first and second edges of the plurality of non-binding edges. The tab is configured to mate with the at least one tab mating feature. The at least one tab mating feature is configured such that the tab is positionable in at least two longitudinal positions along the first non-binding edge and in at least two longitudinal positions along the second non-binding edge. | 05-13-2010 |
20100209177 | ADJUSTABLE TAB DIVIDER - Embodiments of the invention relate to dividers with tabs adjustable along at least two edges of the binder. One embodiment is directed to a divider for use in a binder. The divider comprises a panel, the panel comprising a binding edge and a plurality of non-binding edges, and a tab. The panel comprises at least one binding feature adjacent the binding edge and at least one tab mating feature adjacent at least first and second edges of the plurality of non-binding edges. The tab is configured to mate with the at least one tab mating feature. The at least one tab mating feature is configured such that the tab is positionable in at least two longitudinal positions along the first non-binding edge and in at least two longitudinal positions along the second non-binding edge. | 08-19-2010 |
20110041245 | METHOD AND APPARATUS FOR PREVENTING MOTION OF A BASSINET - An infant apparatus operable to swing manually or automatically. The infant apparatus includes a frame assembly, a lock assembly, and a cradle assembly. The frame assembly includes a housing and a plurality of legs that extend from the housing. The housing includes motor, a first moveable member supported by the housing and coupled to the motor, and a second moveable member supported by the housing and coupled to the first moveable member, the second moveable member including a plurality of nibs. The lock assembly includes a slideable member supported by the housing and adapted to move between a first position and a second position, and a third moveable member coupled to the slideable member, the third moveable member adapted to engage the plurality of nibs when the slideable member is in the second position. The cradle assembly is coupled to the second moveable member and is adapted to swing when the slideable member is in the first position. | 02-24-2011 |